BAIAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.86343967
2axonemal dynein complex assembly (GO:0070286)5.81076543
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.77059888
4ionotropic glutamate receptor signaling pathway (GO:0035235)5.38771211
5synaptic vesicle exocytosis (GO:0016079)5.26051487
6vocalization behavior (GO:0071625)5.17979712
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.16939695
8locomotory exploration behavior (GO:0035641)5.01209845
9regulation of synapse structural plasticity (GO:0051823)4.97454057
10synaptic vesicle maturation (GO:0016188)4.87861421
11protein localization to synapse (GO:0035418)4.87808223
12glutamate receptor signaling pathway (GO:0007215)4.87237771
13regulation of neuronal synaptic plasticity (GO:0048168)4.81031796
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.80557063
15synaptic transmission, glutamatergic (GO:0035249)4.79565699
16regulation of glutamate receptor signaling pathway (GO:1900449)4.76279879
17regulation of long-term neuronal synaptic plasticity (GO:0048169)4.73284403
18glutamate secretion (GO:0014047)4.60980013
19positive regulation of synapse maturation (GO:0090129)4.43609070
20cytoskeletal anchoring at plasma membrane (GO:0007016)4.43069285
21regulation of excitatory postsynaptic membrane potential (GO:0060079)4.42798460
22neurotransmitter-gated ion channel clustering (GO:0072578)4.41408559
23neuron-neuron synaptic transmission (GO:0007270)4.40374806
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.39815461
25motile cilium assembly (GO:0044458)4.34032433
26cilium or flagellum-dependent cell motility (GO:0001539)4.31683342
27negative regulation of amino acid transport (GO:0051956)4.25974286
28regulation of dendritic spine morphogenesis (GO:0061001)4.21751053
29G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.14673071
30regulation of glutamate secretion (GO:0014048)4.07371579
31behavioral defense response (GO:0002209)4.07298332
32behavioral fear response (GO:0001662)4.07298332
33positive regulation of dendritic spine morphogenesis (GO:0061003)4.06513352
34regulation of postsynaptic membrane potential (GO:0060078)4.05941120
35* regulation of synaptic plasticity (GO:0048167)4.03955549
36long-term memory (GO:0007616)4.03948804
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.03559497
38cilium movement (GO:0003341)4.03356062
39regulation of synaptic vesicle exocytosis (GO:2000300)4.00407873
40desmosome organization (GO:0002934)3.96428842
41neuromuscular process controlling balance (GO:0050885)3.95980117
42neuronal action potential propagation (GO:0019227)3.91468560
43transmission of nerve impulse (GO:0019226)3.85436339
44regulation of synaptic vesicle transport (GO:1902803)3.77880916
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.76254059
46gamma-aminobutyric acid transport (GO:0015812)3.74364084
47serotonin metabolic process (GO:0042428)3.70508078
48positive regulation of membrane potential (GO:0045838)3.70278357
49establishment of nucleus localization (GO:0040023)3.65422345
50dendritic spine organization (GO:0097061)3.64192328
51exploration behavior (GO:0035640)3.64075336
52fear response (GO:0042596)3.63507777
53long-term synaptic potentiation (GO:0060291)3.63286410
54long term synaptic depression (GO:0060292)3.62583721
55gamma-aminobutyric acid signaling pathway (GO:0007214)3.58738900
56dendritic spine morphogenesis (GO:0060997)3.58263629
57neurotransmitter secretion (GO:0007269)3.57036397
58positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.52746985
59G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.49716457
60ephrin receptor signaling pathway (GO:0048013)3.49298515
61regulation of vesicle fusion (GO:0031338)3.47695628
62learning (GO:0007612)3.43771287
63regulation of synaptic transmission, glutamatergic (GO:0051966)3.43544526
64positive regulation of dendritic spine development (GO:0060999)3.42222691
65behavioral response to cocaine (GO:0048148)3.39015745
66regulation of female receptivity (GO:0045924)3.38806938
67regulation of synapse maturation (GO:0090128)3.38103347
68cerebellar granule cell differentiation (GO:0021707)3.37999062
69neuronal ion channel clustering (GO:0045161)3.37627027
70neuromuscular process (GO:0050905)3.37545094
71regulation of dendritic spine development (GO:0060998)3.36704185
72positive regulation of fibroblast migration (GO:0010763)3.36396909
73apical protein localization (GO:0045176)3.35874031
74membrane depolarization (GO:0051899)3.34895465
75lung epithelium development (GO:0060428)3.33863206
76semaphorin-plexin signaling pathway (GO:0071526)3.32988788
77response to amphetamine (GO:0001975)3.32522170
78synaptic transmission, dopaminergic (GO:0001963)3.31422935
79cellular sodium ion homeostasis (GO:0006883)3.30361807
80synaptic vesicle endocytosis (GO:0048488)3.29154943
81response to histamine (GO:0034776)3.28126326
82cellular potassium ion homeostasis (GO:0030007)3.27859158
83visual learning (GO:0008542)3.27615550
84primary amino compound metabolic process (GO:1901160)3.25183480
85cell-cell junction maintenance (GO:0045217)3.23687458
86dendrite morphogenesis (GO:0048813)3.22737574
87epithelial cilium movement (GO:0003351)3.21842930
88activation of protein kinase A activity (GO:0034199)3.21544267
89associative learning (GO:0008306)3.21051879
90negative regulation of synaptic transmission, GABAergic (GO:0032229)3.21039219
91negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.20868238
92cAMP catabolic process (GO:0006198)3.20570507
93glycine transport (GO:0015816)3.20330631
94amino acid import (GO:0043090)3.17521879
95positive regulation of neurotransmitter secretion (GO:0001956)3.17328305
96regulation of ARF protein signal transduction (GO:0032012)3.16808884
97prepulse inhibition (GO:0060134)3.14613658
98neuromuscular process controlling posture (GO:0050884)3.13814391
99proline transport (GO:0015824)3.13402363
100membrane depolarization during action potential (GO:0086010)3.12431582
101visual behavior (GO:0007632)3.12412893
102neuron cell-cell adhesion (GO:0007158)3.10881400
103positive regulation of neurotransmitter transport (GO:0051590)3.09052399
104startle response (GO:0001964)3.07390087
105inner ear receptor cell development (GO:0060119)3.07009463
106layer formation in cerebral cortex (GO:0021819)3.06567458
107regulation of neurotransmitter secretion (GO:0046928)3.04408235
108neuron recognition (GO:0008038)3.02715049
109epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.01798149
110establishment of skin barrier (GO:0061436)3.01789875
111left/right pattern formation (GO:0060972)3.01400855
112* regulation of synaptic transmission (GO:0050804)3.01127572
113auditory behavior (GO:0031223)3.00664991
114synaptic transmission (GO:0007268)3.00170239
115regulation of water loss via skin (GO:0033561)2.96560938
116regulation of protein kinase A signaling (GO:0010738)2.96285500
117asymmetric protein localization (GO:0008105)2.96122100
118female mating behavior (GO:0060180)2.94523258
119sodium ion export (GO:0071436)2.94068077
120signal complex assembly (GO:0007172)2.94044402
121hemidesmosome assembly (GO:0031581)2.93901996
122multicellular organismal water homeostasis (GO:0050891)2.90785891
123cerebellar Purkinje cell layer development (GO:0021680)2.84008518
124L-amino acid import (GO:0043092)2.76029998
125long-chain fatty acid biosynthetic process (GO:0042759)2.72301003
126peptidyl-tyrosine autophosphorylation (GO:0038083)2.68793784
127potassium ion homeostasis (GO:0055075)2.67919942
128protein localization to endosome (GO:0036010)2.66711252
129primary alcohol catabolic process (GO:0034310)2.63817257
130cell junction maintenance (GO:0034331)2.62910306
131neurotransmitter transport (GO:0006836)2.62505993
132protein retention in ER lumen (GO:0006621)2.61068565
133retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.60750214
134regulation of neurotransmitter levels (GO:0001505)2.59600735
135chemosensory behavior (GO:0007635)2.57569134
136cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.55996288
137cellular component maintenance (GO:0043954)2.55307733
138negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.53754475
139negative regulation of dendrite morphogenesis (GO:0050774)2.52114524
140negative regulation of inclusion body assembly (GO:0090084)2.50822492
141regulation of cholesterol biosynthetic process (GO:0045540)2.49117744
142water homeostasis (GO:0030104)2.47515614
143mating behavior (GO:0007617)2.46145735
144dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.46135978
145dopamine receptor signaling pathway (GO:0007212)2.46045513
146microtubule bundle formation (GO:0001578)2.44261866
147activation of Rac GTPase activity (GO:0032863)2.42704851
148cell migration in hindbrain (GO:0021535)2.42274351
149establishment of apical/basal cell polarity (GO:0035089)2.39326034
150diterpenoid biosynthetic process (GO:0016102)2.36553368
151axoneme assembly (GO:0035082)2.34724026
152myelin maintenance (GO:0043217)2.34579256
153maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.34474859
154cell volume homeostasis (GO:0006884)2.30359755
155COPI coating of Golgi vesicle (GO:0048205)2.30082927
156Golgi transport vesicle coating (GO:0048200)2.30082927
157axon ensheathment in central nervous system (GO:0032291)2.29997574
158central nervous system myelination (GO:0022010)2.29997574
159cell communication by electrical coupling (GO:0010644)2.29852096
160regulation of microtubule-based movement (GO:0060632)2.25065241

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.95668245
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.63852668
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.11635451
4GBX2_23144817_ChIP-Seq_PC3_Human3.12039836
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08860264
6* RARB_27405468_Chip-Seq_BRAIN_Mouse3.06068354
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99970017
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89804719
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.83262126
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72536235
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70347690
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70347690
13DROSHA_22980978_ChIP-Seq_HELA_Human2.59509188
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57122809
15REST_21632747_ChIP-Seq_MESCs_Mouse2.51212732
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48286545
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44924763
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.43697944
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42029112
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.39039588
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37261561
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.28065496
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.27661804
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26676739
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.24061267
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22888395
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.19145482
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.14755409
29RARG_19884340_ChIP-ChIP_MEFs_Mouse2.10517762
30REST_18959480_ChIP-ChIP_MESCs_Mouse2.04740797
31* RACK7_27058665_Chip-Seq_MCF-7_Human2.03946252
32ERG_21242973_ChIP-ChIP_JURKAT_Human2.00059885
33ZNF263_19887448_ChIP-Seq_K562_Human1.92242272
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.88568740
35AR_21572438_ChIP-Seq_LNCaP_Human1.81708117
36SRY_22984422_ChIP-ChIP_TESTIS_Rat1.75307150
37P68_20966046_ChIP-Seq_HELA_Human1.70126582
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60318662
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.51791408
40* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.51558559
41* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.51364482
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50797910
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47343173
44CREB1_26743006_Chip-Seq_LNCaP_Human1.47133107
45* RUNX1_27514584_Chip-Seq_MCF-7_Human1.41691624
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.41434207
47* KDM2B_26808549_Chip-Seq_K562_Human1.40630108
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.40543242
49* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.40027723
50* TP63_22573176_ChIP-Seq_HFKS_Human1.39984732
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37261050
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36044904
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.35676723
54ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35536579
55* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34650164
56SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.33384948
57RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.32871628
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31850331
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.31759095
60* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31520720
61* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28487010
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28452544
63SMAD4_21799915_ChIP-Seq_A2780_Human1.27687331
64SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27549112
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.27428441
66P63_26484246_Chip-Seq_KERATINOCYTES_Human1.26666090
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.25813631
68SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25545352
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24899847
70SA1_27219007_Chip-Seq_ERYTHROID_Human1.24812935
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24081869
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23849849
73CTCF_27219007_Chip-Seq_Bcells_Human1.23780740
74* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23145480
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.22174041
76* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20358128
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17195481
78* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15230133
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.15226457
80OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.14866088
81SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14521560
82* AR_19668381_ChIP-Seq_PC3_Human1.13557408
83* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12701283
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12642444
85SMAD3_21741376_ChIP-Seq_HESCs_Human1.12001041
86* TP53_23651856_ChIP-Seq_MEFs_Mouse1.11147611
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11104757
88TP53_22127205_ChIP-Seq_IMR90_Human1.10819437
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10610737
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.10357572
91* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09516882
92CLOCK_20551151_ChIP-Seq_293T_Human1.09242836
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09063682
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08777694
95* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07084993
96* KLF5_25053715_ChIP-Seq_YYC3_Human1.06352347
97KDM2B_26808549_Chip-Seq_DND41_Human1.06087475
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06057318
99TP53_20018659_ChIP-ChIP_R1E_Mouse1.05906796
100P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05605643
101AHR_22903824_ChIP-Seq_MCF-7_Human1.05480593
102PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05165940
103AR_25329375_ChIP-Seq_VCAP_Human1.04746095
104KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03460499
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03023686
106ELF1_20517297_ChIP-Seq_JURKAT_Human1.02632797
107GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02008311
108STAT3_23295773_ChIP-Seq_U87_Human1.01344467
109CTCF_20526341_ChIP-Seq_ESCs_Human1.01062371
110CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00115914
111TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00059413
112OCT4_19829295_ChIP-Seq_ESCs_Human0.99592893
113P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98248556
114ARNT_22903824_ChIP-Seq_MCF-7_Human0.97921130
115ATF3_27146783_Chip-Seq_COLON_Human0.97164224
116BCOR_27268052_Chip-Seq_Bcells_Human0.96739890
117TET1_21490601_ChIP-Seq_MESCs_Mouse0.95383831
118YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94783401
119* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94500348
120GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94380088
121* FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94119395
122* LXR_22292898_ChIP-Seq_THP-1_Human0.91638266
123SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.91480364
124TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.91339144
125CBX2_27304074_Chip-Seq_ESCs_Mouse0.91337041
126NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91207723
127* TCF4_23295773_ChIP-Seq_U87_Human0.91034006
128* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90647905
129BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90120031
130* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90103173
131KDM2B_26808549_Chip-Seq_JURKAT_Human0.89139511
132TP53_16413492_ChIP-PET_HCT116_Human0.88277749
133ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86531405
134ZNF274_21170338_ChIP-Seq_K562_Hela0.84882328
135P300_19829295_ChIP-Seq_ESCs_Human0.82763295
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82636110
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82636110
138SMAD4_21741376_ChIP-Seq_HESCs_Human0.81873907
139BCAT_22108803_ChIP-Seq_LS180_Human0.81576174
140* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81503602
141SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80238851
142PRDM14_20953172_ChIP-Seq_ESCs_Human0.77300525
143TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.76783559
144RNF2_27304074_Chip-Seq_NSC_Mouse0.76653706
145KLF4_19829295_ChIP-Seq_ESCs_Human0.76502145
146ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75990356
147SMC4_20622854_ChIP-Seq_HELA_Human0.75603636
148SMAD4_21741376_ChIP-Seq_EPCs_Human0.75407638
149TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.75335044
150TP53_18474530_ChIP-ChIP_U2OS_Human0.74762709
151GATA1_22025678_ChIP-Seq_K562_Human0.74615380
152NR3C1_21868756_ChIP-Seq_MCF10A_Human0.73747509

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.74283617
2MP0003880_abnormal_central_pattern4.83794353
3MP0002822_catalepsy4.59962055
4* MP0003635_abnormal_synaptic_transmissio4.40220645
5MP0009745_abnormal_behavioral_response3.89447180
6* MP0002063_abnormal_learning/memory/cond3.77137209
7MP0002064_seizures3.30763736
8MP0004270_analgesia3.22372229
9MP0002572_abnormal_emotion/affect_behav3.05813264
10MP0009046_muscle_twitch2.92577879
11MP0000566_synostosis2.91037991
12MP0001968_abnormal_touch/_nociception2.79050827
13MP0002272_abnormal_nervous_system2.45418763
14MP0001501_abnormal_sleep_pattern2.44919249
15MP0001440_abnormal_grooming_behavior2.40044751
16MP0002736_abnormal_nociception_after2.36955814
17MP0001486_abnormal_startle_reflex2.30901514
18MP0000579_abnormal_nail_morphology2.23581809
19MP0005171_absent_coat_pigmentation2.20215138
20MP0003705_abnormal_hypodermis_morpholog2.19928294
21MP0002735_abnormal_chemical_nociception2.17201680
22MP0005409_darkened_coat_color2.06958673
23MP0005423_abnormal_somatic_nervous2.06250100
24MP0002733_abnormal_thermal_nociception1.99113618
25MP0001970_abnormal_pain_threshold1.96724432
26MP0002796_impaired_skin_barrier1.93158253
27MP0008569_lethality_at_weaning1.89955566
28MP0008875_abnormal_xenobiotic_pharmacok1.88285778
29MP0002734_abnormal_mechanical_nocicepti1.85625580
30MP0002067_abnormal_sensory_capabilities1.76057256
31MP0002909_abnormal_adrenal_gland1.75680026
32MP0003329_amyloid_beta_deposits1.73390327
33MP0004858_abnormal_nervous_system1.72352870
34MP0003879_abnormal_hair_cell1.70404482
35MP0003075_altered_response_to1.64829993
36MP0003453_abnormal_keratinocyte_physiol1.62308716
37MP0004811_abnormal_neuron_physiology1.60875033
38MP0000778_abnormal_nervous_system1.52349867
39MP0002557_abnormal_social/conspecific_i1.48980895
40MP0005377_hearing/vestibular/ear_phenot1.48467558
41MP0003878_abnormal_ear_physiology1.48467558
42MP0005058_abnormal_lysosome_morphology1.47517347
43MP0005499_abnormal_olfactory_system1.47087899
44MP0005394_taste/olfaction_phenotype1.47087899
45MP0000751_myopathy1.43059369
46MP0002249_abnormal_larynx_morphology1.42740007
47MP0003633_abnormal_nervous_system1.41539810
48MP0000955_abnormal_spinal_cord1.38557107
49MP0010678_abnormal_skin_adnexa1.38191298
50MP0004924_abnormal_behavior1.36566462
51MP0005386_behavior/neurological_phenoty1.36566462
52MP0002184_abnormal_innervation1.36233077
53MP0000678_abnormal_parathyroid_gland1.34930281
54MP0004885_abnormal_endolymph1.34561580
55MP0002066_abnormal_motor_capabilities/c1.34074415
56MP0001502_abnormal_circadian_rhythm1.32359820
57MP0005646_abnormal_pituitary_gland1.32237418
58MP0002882_abnormal_neuron_morphology1.31263152
59MP0001177_atelectasis1.29381991
60MP0004142_abnormal_muscle_tone1.29339403
61MP0005501_abnormal_skin_physiology1.29014830
62MP0008961_abnormal_basal_metabolism1.28591932
63MP0008789_abnormal_olfactory_epithelium1.27490557
64MP0003123_paternal_imprinting1.26743762
65MP0002098_abnormal_vibrissa_morphology1.23393114
66MP0009780_abnormal_chondrocyte_physiolo1.23020097
67MP0008874_decreased_physiological_sensi1.21220288
68MP0010030_abnormal_orbit_morphology1.17830153
69MP0003631_nervous_system_phenotype1.17228663
70MP0003690_abnormal_glial_cell1.14320973
71MP0004019_abnormal_vitamin_homeostasis1.12988814
72MP0000537_abnormal_urethra_morphology1.12983845
73MP0008260_abnormal_autophagy1.10609752
74MP0000762_abnormal_tongue_morphology1.09531005
75MP0004233_abnormal_muscle_weight1.07511978
76MP0002089_abnormal_postnatal_growth/wei1.07286166
77MP0003566_abnormal_cell_adhesion1.07115735
78MP0000383_abnormal_hair_follicle1.05509657
79MP0001849_ear_inflammation1.02717915
80MP0002152_abnormal_brain_morphology1.02517463
81MP0003787_abnormal_imprinting1.01059392
82MP0005076_abnormal_cell_differentiation1.01029242
83MP0010771_integument_phenotype0.99315129
84MP0005257_abnormal_intraocular_pressure0.99179066
85MP0001346_abnormal_lacrimal_gland0.98415064
86MP0003172_abnormal_lysosome_physiology0.97708971
87MP0009840_abnormal_foam_cell0.96819433
88MP0002069_abnormal_eating/drinking_beha0.92798964
89MP0001984_abnormal_olfaction0.92167374
90MP0008872_abnormal_physiological_respon0.91688641
91MP0000467_abnormal_esophagus_morphology0.89893008
92MP0001188_hyperpigmentation0.89738610
93MP0010234_abnormal_vibrissa_follicle0.89113169
94MP0001905_abnormal_dopamine_level0.88213063
95MP0003137_abnormal_impulse_conducting0.85841923
96MP0002876_abnormal_thyroid_physiology0.83747561
97MP0002653_abnormal_ependyma_morphology0.83484096
98MP0005451_abnormal_body_composition0.83287989
99MP0001529_abnormal_vocalization0.82598217
100MP0004133_heterotaxia0.82116258
101MP0000604_amyloidosis0.81768019
102MP0005167_abnormal_blood-brain_barrier0.81621795
103MP0002234_abnormal_pharynx_morphology0.78240073
104MP0003283_abnormal_digestive_organ0.78209032
105MP0002090_abnormal_vision0.76987646
106MP0001216_abnormal_epidermal_layer0.76708791
107MP0001299_abnormal_eye_distance/0.76547032
108MP0003632_abnormal_nervous_system0.74938763
109MP0005535_abnormal_body_temperature0.74755474
110MP0004085_abnormal_heartbeat0.74582054
111MP0004510_myositis0.74308636
112MP0000681_abnormal_thyroid_gland0.72435447
113MP0000026_abnormal_inner_ear0.71384995
114MP0001765_abnormal_ion_homeostasis0.70328911
115MP0000003_abnormal_adipose_tissue0.69016900
116MP0005248_abnormal_Harderian_gland0.68140738
117MP0001485_abnormal_pinna_reflex0.67798010
118MP0005645_abnormal_hypothalamus_physiol0.67726506
119MP0002332_abnormal_exercise_endurance0.66581686
120MP0005410_abnormal_fertilization0.66005598
121MP0002229_neurodegeneration0.65332904
122MP0003634_abnormal_glial_cell0.65271561
123MP0006276_abnormal_autonomic_nervous0.64738108
124MP0001963_abnormal_hearing_physiology0.60393593
125MP0001664_abnormal_digestion0.59642726
126MP0004145_abnormal_muscle_electrophysio0.57744552
127MP0003045_fibrosis0.56468106
128MP0000920_abnormal_myelination0.56407654
129MP0002269_muscular_atrophy0.55496494
130MP0003091_abnormal_cell_migration0.53386311
131MP0008995_early_reproductive_senescence0.53221909
132MP0005623_abnormal_meninges_morphology0.53173274
133MP0003861_abnormal_nervous_system0.52001909
134* MP0010769_abnormal_survival0.51714021
135MP0004185_abnormal_adipocyte_glucose0.51677806
136MP0005551_abnormal_eye_electrophysiolog0.51505336
137MP0002752_abnormal_somatic_nervous0.51107632
138MP0010770_preweaning_lethality0.50386996
139MP0002082_postnatal_lethality0.50386996
140* MP0010768_mortality/aging0.50108293
141MP0001943_abnormal_respiration0.49292594
142MP0004043_abnormal_pH_regulation0.49113335
143MP0003956_abnormal_body_size0.48914878

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.94236991
2Myokymia (HP:0002411)7.70964265
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.92734053
4Focal seizures (HP:0007359)5.37519221
5Abnormal respiratory epithelium morphology (HP:0012253)5.33163185
6Abnormal respiratory motile cilium morphology (HP:0005938)5.33163185
7Abnormal respiratory motile cilium physiology (HP:0012261)5.12980933
8Abnormal ciliary motility (HP:0012262)4.96867285
9Abnormality of the lower motor neuron (HP:0002366)4.86180784
10Rhinitis (HP:0012384)4.66606872
11Epileptic encephalopathy (HP:0200134)4.62975180
12Progressive cerebellar ataxia (HP:0002073)4.60965081
13Atonic seizures (HP:0010819)4.49368031
14Visual hallucinations (HP:0002367)4.27858867
15Annular pancreas (HP:0001734)4.09457477
16Febrile seizures (HP:0002373)4.04388502
17Genetic anticipation (HP:0003743)3.96652139
18Scanning speech (HP:0002168)3.85861168
19Dialeptic seizures (HP:0011146)3.76721443
20Dysmetria (HP:0001310)3.72662530
21Absence seizures (HP:0002121)3.71632250
22Dysdiadochokinesis (HP:0002075)3.65115166
23Gaze-evoked nystagmus (HP:0000640)3.64136844
24Chronic bronchitis (HP:0004469)3.62539249
25Turricephaly (HP:0000262)3.61788120
26Impaired smooth pursuit (HP:0007772)3.54187523
27Generalized tonic-clonic seizures (HP:0002069)3.42860028
28Decreased circulating renin level (HP:0003351)3.38177565
29Increased circulating renin level (HP:0000848)3.32666686
30Distal upper limb amyotrophy (HP:0007149)3.30743706
31Upper limb amyotrophy (HP:0009129)3.30743706
32Action tremor (HP:0002345)3.28822290
33Hand muscle atrophy (HP:0009130)3.25370343
34Impaired vibration sensation in the lower limbs (HP:0002166)3.25212699
35Broad-based gait (HP:0002136)3.14371966
36Dysmetric saccades (HP:0000641)3.10339207
37Nasal polyposis (HP:0100582)3.09609833
38Amblyopia (HP:0000646)3.03132633
39Hyperactive renin-angiotensin system (HP:0000841)2.98984673
40Male infertility (HP:0003251)2.91375871
41Poor eye contact (HP:0000817)2.86748334
42Abnormality of ocular smooth pursuit (HP:0000617)2.82686933
43Torticollis (HP:0000473)2.82171258
44Supranuclear gaze palsy (HP:0000605)2.78412749
45Impaired social interactions (HP:0000735)2.72290826
46Abnormal social behavior (HP:0012433)2.72290826
47Postural instability (HP:0002172)2.69227351
48Hyperventilation (HP:0002883)2.67859013
49Atelectasis (HP:0100750)2.67742252
50Bronchiectasis (HP:0002110)2.66585098
51Abnormality of the nasal mucosa (HP:0000433)2.61105698
52Status epilepticus (HP:0002133)2.60919079
53Ventricular fibrillation (HP:0001663)2.60847002
54Lower limb amyotrophy (HP:0007210)2.60751560
55Depression (HP:0000716)2.60183544
56Urinary bladder sphincter dysfunction (HP:0002839)2.60075237
57Neuronal loss in central nervous system (HP:0002529)2.58383759
58Anxiety (HP:0000739)2.58021019
59Abnormal eating behavior (HP:0100738)2.53945942
60Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.52244458
61Focal dystonia (HP:0004373)2.51129967
62Truncal ataxia (HP:0002078)2.50410157
63Infertility (HP:0000789)2.50322118
64Stereotypic behavior (HP:0000733)2.46157893
65Hemiplegia (HP:0002301)2.45327482
66Epileptiform EEG discharges (HP:0011182)2.45005723
67Apathy (HP:0000741)2.44763839
68Impaired vibratory sensation (HP:0002495)2.41256734
69Ankle clonus (HP:0011448)2.33380519
70Diminished motivation (HP:0000745)2.30699058
71Hyperacusis (HP:0010780)2.28337296
72Short nail (HP:0001799)2.27652166
73Obstructive sleep apnea (HP:0002870)2.27536675
74Craniofacial dystonia (HP:0012179)2.27457727
75Hyperkalemia (HP:0002153)2.26667317
76Intention tremor (HP:0002080)2.26299476
77Incomplete penetrance (HP:0003829)2.25169945
78Hemiparesis (HP:0001269)2.21249112
79Abnormality of saccadic eye movements (HP:0000570)2.20516877
80Urinary urgency (HP:0000012)2.20292994
81Truncus arteriosus (HP:0001660)2.15970887
82Ankyloglossia (HP:0010296)2.15817400
83Excessive salivation (HP:0003781)2.13180185
84Drooling (HP:0002307)2.13180185
85Confusion (HP:0001289)2.13157248
86Exercise-induced myalgia (HP:0003738)2.11845852
87Protruding tongue (HP:0010808)2.11776762
88Generalized myoclonic seizures (HP:0002123)2.11017575
89Aplasia involving bones of the extremities (HP:0009825)2.10423779
90Aplasia involving bones of the upper limbs (HP:0009823)2.10423779
91Aplasia of the phalanges of the hand (HP:0009802)2.10423779
92Distal lower limb amyotrophy (HP:0008944)2.08915946
93Resting tremor (HP:0002322)2.06882469
94Pointed chin (HP:0000307)2.06221684
95Spinal cord compression (HP:0002176)2.05110808
96Nuclear cataract (HP:0100018)2.02816986
97Distal lower limb muscle weakness (HP:0009053)2.00291746
98Choroideremia (HP:0001139)1.99764098
99Bradykinesia (HP:0002067)1.99361696
100Abnormality of the periventricular white matter (HP:0002518)1.99304396
101Bronchomalacia (HP:0002780)1.99254163
102Coronal craniosynostosis (HP:0004440)1.98691522
103Sleep apnea (HP:0010535)1.98235307
104Axonal loss (HP:0003447)1.97562839
105Blue irides (HP:0000635)1.96040046
106Stridor (HP:0010307)1.95798328
107Abnormality of the distal phalanges of the toes (HP:0010182)1.95290667
108Diplopia (HP:0000651)1.94875066
109Abnormality of binocular vision (HP:0011514)1.94875066
110Dyskinesia (HP:0100660)1.93175215
111Fetal akinesia sequence (HP:0001989)1.92853080
112Hyperaldosteronism (HP:0000859)1.92522100
113Insomnia (HP:0100785)1.92125095
114Lip pit (HP:0100267)1.91198670
115Cerebral inclusion bodies (HP:0100314)1.91172161
116Clumsiness (HP:0002312)1.89651658
117Spastic gait (HP:0002064)1.87449254
118Achilles tendon contracture (HP:0001771)1.87371410
119Broad face (HP:0000283)1.84866657
120Spinal muscular atrophy (HP:0007269)1.83585422
121Absent speech (HP:0001344)1.80516952
122Toxemia of pregnancy (HP:0100603)1.80474629
123Recurrent otitis media (HP:0000403)1.79978079
124Retinal dysplasia (HP:0007973)1.79177430
125Abnormality of nail color (HP:0100643)1.78039291
126Lower limb hyperreflexia (HP:0002395)1.77471338
127Aqueductal stenosis (HP:0002410)1.76467993
128Dynein arm defect of respiratory motile cilia (HP:0012255)1.74435969
129Absent/shortened dynein arms (HP:0200106)1.74435969
130EEG with generalized epileptiform discharges (HP:0011198)1.74299253
131Abnormality of the Achilles tendon (HP:0005109)1.73108528
132Natal tooth (HP:0000695)1.72760895
133Narrow nasal bridge (HP:0000446)1.72053927
134Neurofibrillary tangles (HP:0002185)1.70732753
135Thickened helices (HP:0000391)1.70533813
136Methylmalonic acidemia (HP:0002912)1.70430629
137Adrenal overactivity (HP:0002717)1.69887621
138Abnormality of renin-angiotensin system (HP:0000847)1.69629496
139Milia (HP:0001056)1.68739424
140Advanced eruption of teeth (HP:0006288)1.68492677
141Hammertoe (HP:0001765)1.67390239
142Shallow orbits (HP:0000586)1.67299386
143Distal sensory impairment (HP:0002936)1.66997396
144Testicular atrophy (HP:0000029)1.66792022
145Thick nail (HP:0001805)1.64880494
146Mutism (HP:0002300)1.63956597
147Occipital encephalocele (HP:0002085)1.63697184
148Flat acetabular roof (HP:0003180)1.62769220
149Fragile nails (HP:0001808)1.62617399
150Ulnar bowing (HP:0003031)1.62431995
151Abnormality of the salivary glands (HP:0010286)1.62092524
152Abnormality of permanent molar morphology (HP:0011071)1.60990431
153Abnormality of the dental root (HP:0006486)1.60990431
154Taurodontia (HP:0000679)1.60990431
155Bell-shaped thorax (HP:0001591)1.60976748
156Akinesia (HP:0002304)1.60921437
157Pili torti (HP:0003777)1.60832486
158Bifid scrotum (HP:0000048)1.58583472
159Cerebral aneurysm (HP:0004944)1.57757917
160Cholecystitis (HP:0001082)1.56702396
161Abnormal gallbladder physiology (HP:0012438)1.56702396
162Peripheral hypomyelination (HP:0007182)1.54599790
163Nail dystrophy (HP:0008404)1.52124633
164Plantar hyperkeratosis (HP:0007556)1.51964884
165Rapidly progressive (HP:0003678)1.49574100
166Glucose intolerance (HP:0000833)1.47776829

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA47.15464576
2NTRK34.88486848
3EPHA24.60585086
4MAP3K93.05608872
5DAPK22.67443010
6DAPK12.50032601
7TRIB32.49648163
8TESK12.31016253
9MST1R2.13522940
10RIPK42.09004979
11TNIK2.03066357
12KSR22.02158436
13NTRK21.95081814
14PRKD31.94044710
15SIK11.91300072
16CDK121.89755757
17CAMK1D1.79618400
18MINK11.75300113
19MAP3K41.71437956
20PLK21.63109476
21BMX1.62351473
22TYRO31.60700741
23MAP2K71.58271531
24MAP3K131.57807011
25DDR21.57358830
26CAMKK11.55414734
27PRPF4B1.53516299
28PAK61.53415847
29ICK1.49009380
30FES1.47703983
31CAMK2B1.47631726
32PINK11.47125606
33CDK51.43737695
34KSR11.40692961
35MET1.35469788
36LIMK11.34445665
37STK381.33593746
38LMTK21.29874094
39MAP3K21.29573364
40PIM21.29032690
41NEK61.27902029
42ARAF1.25479517
43CAMK1G1.24426108
44FGR1.24251154
45TESK21.21640703
46MAP3K61.20045888
47EEF2K1.18683885
48RAF11.18327036
49SMG11.17448611
50SIK21.16964407
51UHMK11.16741702
52CAMK2A1.15790846
53PTK2B1.15391071
54IRAK31.15314363
55NTRK11.14813711
56PRKCG1.14459924
57TAOK11.14132283
58CASK1.08170098
59CAMK11.07412981
60MAP2K41.06753763
61CDK191.03449879
62MARK11.03424345
63MAPKAPK31.03048482
64EPHB10.99441778
65PRKCI0.99389550
66MAP3K30.99268309
67MAP3K110.96311641
68SGK10.93678776
69TAOK20.93179628
70PRKD20.86867195
71CDK150.84642248
72CDK180.84083207
73* MARK20.81260970
74CAMKK20.80834694
75MAPK130.78447621
76EPHB20.77000272
77MTOR0.75675452
78AKT30.75421234
79CSNK1G20.75097104
80GRK50.74508425
81CDK11A0.73992985
82RPS6KA20.73543152
83CDK140.72290440
84NME10.72179357
85MAP3K70.70332779
86DMPK0.69747029
87MAP3K120.68777470
88BMPR20.67452097
89TNK20.63863121
90LATS20.62987136
91PDK10.62613369
92STK110.62396998
93CDC42BPA0.61724101
94CAMK2G0.61213488
95PRKCH0.60338527
96PDPK10.60324013
97ERBB20.60102015
98ERN10.60048988
99MAP3K10.58944214
100ALK0.57772350
101IRAK20.57402884
102PAK40.55535547
103DYRK1A0.55175223
104MAPK150.55167893
105MOS0.53841713
106RPS6KA30.52641019
107SGK2230.51966259
108SGK4940.51966259
109PKN20.51271429
110SCYL20.49798051
111CAMK2D0.49008807
112SGK20.48925908
113CAMK40.48513192
114ABL20.48450059
115CLK10.48179515
116AURKA0.47962952
117FER0.47295482
118OXSR10.46451832
119NME20.46291660
120SGK30.45408433
121MATK0.45173725
122ROCK20.44227145
123PRKCE0.43612608
124BRAF0.42990598
125CSNK1A1L0.41994957
126BCR0.41554141
127PTK20.41442650
128PRKCZ0.41280070
129PDGFRA0.41039408
130FYN0.40889502
131DAPK30.39538431
132PHKG10.38041698
133PHKG20.38041698
134RIPK10.37851798
135FGFR10.37539452
136MAP2K10.37428398
137MAPK100.36827915
138RET0.35758840

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.03015128
2Circadian entrainment_Homo sapiens_hsa047133.07717891
3Olfactory transduction_Homo sapiens_hsa047402.94498319
4Long-term potentiation_Homo sapiens_hsa047202.88145450
5Amphetamine addiction_Homo sapiens_hsa050312.86425948
6Synaptic vesicle cycle_Homo sapiens_hsa047212.85403292
7Glutamatergic synapse_Homo sapiens_hsa047242.80005079
8Morphine addiction_Homo sapiens_hsa050322.73613962
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.67462958
10GABAergic synapse_Homo sapiens_hsa047272.61640468
11Salivary secretion_Homo sapiens_hsa049702.20472972
12Phenylalanine metabolism_Homo sapiens_hsa003602.17710157
13Dopaminergic synapse_Homo sapiens_hsa047282.13348914
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00654407
15Histidine metabolism_Homo sapiens_hsa003401.87756785
16Cocaine addiction_Homo sapiens_hsa050301.86487014
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.85360815
18Cholinergic synapse_Homo sapiens_hsa047251.80012008
19Calcium signaling pathway_Homo sapiens_hsa040201.78627581
20Oxytocin signaling pathway_Homo sapiens_hsa049211.78260377
21Gastric acid secretion_Homo sapiens_hsa049711.74694498
22Insulin secretion_Homo sapiens_hsa049111.73185301
23Long-term depression_Homo sapiens_hsa047301.70630911
24Taste transduction_Homo sapiens_hsa047421.67122732
25Vitamin B6 metabolism_Homo sapiens_hsa007501.61787021
26Renin secretion_Homo sapiens_hsa049241.57347672
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.55155308
28cAMP signaling pathway_Homo sapiens_hsa040241.50692504
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49530949
30GnRH signaling pathway_Homo sapiens_hsa049121.44793078
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.44620344
32Serotonergic synapse_Homo sapiens_hsa047261.42153382
33Tyrosine metabolism_Homo sapiens_hsa003501.36861031
34Gap junction_Homo sapiens_hsa045401.29860579
35Notch signaling pathway_Homo sapiens_hsa043301.28667367
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24929001
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23093824
38beta-Alanine metabolism_Homo sapiens_hsa004101.18986190
39Collecting duct acid secretion_Homo sapiens_hsa049661.16665302
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16267576
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13516485
42Nitrogen metabolism_Homo sapiens_hsa009101.11889820
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.10366368
44Axon guidance_Homo sapiens_hsa043601.04745261
45Estrogen signaling pathway_Homo sapiens_hsa049151.04489565
46Tight junction_Homo sapiens_hsa045301.03834761
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02169915
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.02139711
49Circadian rhythm_Homo sapiens_hsa047101.01914124
50Lysosome_Homo sapiens_hsa041421.00452606
51Glioma_Homo sapiens_hsa052140.99134211
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99073712
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.96611336
54Fatty acid biosynthesis_Homo sapiens_hsa000610.96194260
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96028476
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95720178
57Type II diabetes mellitus_Homo sapiens_hsa049300.94908161
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93388647
59Arginine and proline metabolism_Homo sapiens_hsa003300.91206294
60Melanogenesis_Homo sapiens_hsa049160.90975715
61Other glycan degradation_Homo sapiens_hsa005110.89864774
62Sphingolipid metabolism_Homo sapiens_hsa006000.88250052
63ErbB signaling pathway_Homo sapiens_hsa040120.86055729
64ABC transporters_Homo sapiens_hsa020100.83653069
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83461851
66Pancreatic secretion_Homo sapiens_hsa049720.79442692
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.78217758
68Choline metabolism in cancer_Homo sapiens_hsa052310.78152960
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78094389
70Dorso-ventral axis formation_Homo sapiens_hsa043200.77150445
71Rap1 signaling pathway_Homo sapiens_hsa040150.75942646
72Thyroid hormone synthesis_Homo sapiens_hsa049180.74259420
73Hippo signaling pathway_Homo sapiens_hsa043900.74007467
74Oocyte meiosis_Homo sapiens_hsa041140.73764450
75Bile secretion_Homo sapiens_hsa049760.71357715
76Vibrio cholerae infection_Homo sapiens_hsa051100.71085957
77VEGF signaling pathway_Homo sapiens_hsa043700.69791506
78Dilated cardiomyopathy_Homo sapiens_hsa054140.68939517
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68936763
80MAPK signaling pathway_Homo sapiens_hsa040100.68906222
81AMPK signaling pathway_Homo sapiens_hsa041520.68068830
82Fructose and mannose metabolism_Homo sapiens_hsa000510.67667601
83Insulin signaling pathway_Homo sapiens_hsa049100.64616355
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64279070
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63691276
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61097751
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60075710
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59644515
89Arginine biosynthesis_Homo sapiens_hsa002200.59210183
90* Adherens junction_Homo sapiens_hsa045200.56486809
91Chemical carcinogenesis_Homo sapiens_hsa052040.56212467
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54416843
93Inositol phosphate metabolism_Homo sapiens_hsa005620.54308725
94Ras signaling pathway_Homo sapiens_hsa040140.53653304
95mTOR signaling pathway_Homo sapiens_hsa041500.52609719
96Biosynthesis of amino acids_Homo sapiens_hsa012300.49196161
97Endometrial cancer_Homo sapiens_hsa052130.49028625
98Cardiac muscle contraction_Homo sapiens_hsa042600.47586830
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.47467060
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47354079
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47248065
102Glucagon signaling pathway_Homo sapiens_hsa049220.47193774
103Amoebiasis_Homo sapiens_hsa051460.43842017
104Sulfur relay system_Homo sapiens_hsa041220.42429916
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.42314831
106Wnt signaling pathway_Homo sapiens_hsa043100.42178805
107Ovarian steroidogenesis_Homo sapiens_hsa049130.40945922
108Steroid biosynthesis_Homo sapiens_hsa001000.40457157
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39844653
110Prion diseases_Homo sapiens_hsa050200.38405668
111Phototransduction_Homo sapiens_hsa047440.38372321
112* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38237639
113Endocytosis_Homo sapiens_hsa041440.37999949
114Non-small cell lung cancer_Homo sapiens_hsa052230.37879946
115African trypanosomiasis_Homo sapiens_hsa051430.36418003
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34336738
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33748642
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.33424953
119Alcoholism_Homo sapiens_hsa050340.32369263
120Chemokine signaling pathway_Homo sapiens_hsa040620.30789876
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30022556
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.26998053
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26016181
124Type I diabetes mellitus_Homo sapiens_hsa049400.23405909
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21523513
126Platelet activation_Homo sapiens_hsa046110.21114288
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.19803457
128Bladder cancer_Homo sapiens_hsa052190.19802009
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.19610470
130Mineral absorption_Homo sapiens_hsa049780.17695962

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