BAG6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)5.62630421
2fusion of sperm to egg plasma membrane (GO:0007342)5.48468273
3sperm-egg recognition (GO:0035036)4.72880169
4acrosome reaction (GO:0007340)4.71563381
5acrosome assembly (GO:0001675)4.65335474
6Golgi transport vesicle coating (GO:0048200)4.56948844
7COPI coating of Golgi vesicle (GO:0048205)4.56948844
8binding of sperm to zona pellucida (GO:0007339)4.45348572
9heterochromatin organization (GO:0070828)4.40703119
10spermatid development (GO:0007286)4.38826119
11cell wall macromolecule metabolic process (GO:0044036)4.37899100
12cell wall macromolecule catabolic process (GO:0016998)4.37899100
13negative regulation of erythrocyte differentiation (GO:0045647)4.34077984
14piRNA metabolic process (GO:0034587)4.32746376
15cell-cell recognition (GO:0009988)4.27403580
16plasma membrane fusion (GO:0045026)4.23897978
17pre-miRNA processing (GO:0031054)4.01265818
18peptidyl-lysine dimethylation (GO:0018027)3.93500560
19regulation of early endosome to late endosome transport (GO:2000641)3.92604442
20negative regulation of cell size (GO:0045792)3.84847569
21regulation of NFAT protein import into nucleus (GO:0051532)3.81553543
22male meiosis (GO:0007140)3.79009720
23protein retention in ER lumen (GO:0006621)3.78330847
24motile cilium assembly (GO:0044458)3.76493793
25proline biosynthetic process (GO:0006561)3.76113594
26* synaptonemal complex assembly (GO:0007130)3.73964955
27maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.73081017
28* synaptonemal complex organization (GO:0070193)3.70674315
29cilium or flagellum-dependent cell motility (GO:0001539)3.68921671
30gene silencing by RNA (GO:0031047)3.58792764
31chromosome condensation (GO:0030261)3.56689316
32retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.55440705
33multicellular organism reproduction (GO:0032504)3.52700612
34negative regulation of organelle assembly (GO:1902116)3.50671065
35regulation of mammary gland epithelial cell proliferation (GO:0033599)3.48104152
36protein localization to endosome (GO:0036010)3.45766868
37NLS-bearing protein import into nucleus (GO:0006607)3.45437741
38negative regulation of inclusion body assembly (GO:0090084)3.45298642
39gene silencing (GO:0016458)3.43119392
40nucleosome disassembly (GO:0006337)3.40634488
41protein-DNA complex disassembly (GO:0032986)3.40634488
42nuclear pore complex assembly (GO:0051292)3.40601502
43positive regulation of histone deacetylation (GO:0031065)3.40364127
44intracellular estrogen receptor signaling pathway (GO:0030520)3.38484564
453-UTR-mediated mRNA stabilization (GO:0070935)3.36441155
46activation of Rac GTPase activity (GO:0032863)3.35337165
47reproduction (GO:0000003)3.32833661
48RNA stabilization (GO:0043489)3.28446699
49mRNA stabilization (GO:0048255)3.28446699
50axonemal dynein complex assembly (GO:0070286)3.26515740
51regulation of translational fidelity (GO:0006450)3.25593085
52basement membrane organization (GO:0071711)3.23272735
53epithelial cilium movement (GO:0003351)3.22899583
54mannose metabolic process (GO:0006013)3.21652204
55regulation of histone H3-K27 methylation (GO:0061085)3.20812637
56cytoskeletal anchoring at plasma membrane (GO:0007016)3.19519879
57DNA packaging (GO:0006323)3.17820043
58regulation of glucose import in response to insulin stimulus (GO:2001273)3.17047874
59establishment of apical/basal cell polarity (GO:0035089)3.16278181
60glucose 6-phosphate metabolic process (GO:0051156)3.15966560
61regulation of cilium movement (GO:0003352)3.13866929
62embryonic process involved in female pregnancy (GO:0060136)3.13118690
63regulation of hippo signaling (GO:0035330)3.11410905
64cell-cell junction maintenance (GO:0045217)3.08592976
65* spermatogenesis (GO:0007283)3.07492577
66chromatin silencing (GO:0006342)3.07115764
67regulation of cholesterol homeostasis (GO:2000188)3.06417951
68nuclear pore organization (GO:0006999)3.06339364
69* male gamete generation (GO:0048232)3.06007926
70regulation of chromatin binding (GO:0035561)3.04945417
71cell-substrate junction assembly (GO:0007044)3.03614689
72modulation by symbiont of host cellular process (GO:0044068)3.02193972
73semaphorin-plexin signaling pathway (GO:0071526)2.99706301
74mitotic chromosome condensation (GO:0007076)2.98784924
75epithelial cell-cell adhesion (GO:0090136)2.95689825
76pentose-phosphate shunt (GO:0006098)2.95346976
77mitotic sister chromatid cohesion (GO:0007064)2.94696947
78DNA unwinding involved in DNA replication (GO:0006268)2.94109734
79germ cell development (GO:0007281)2.94066439
80left/right pattern formation (GO:0060972)2.92297986
81activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.90216187
82regulation of inclusion body assembly (GO:0090083)2.89498662
83seminiferous tubule development (GO:0072520)2.89264162
84cellular process involved in reproduction in multicellular organism (GO:0022412)2.88458513
85modulation by virus of host process (GO:0019054)2.87808362
86adherens junction assembly (GO:0034333)2.84688048
87cellular response to epidermal growth factor stimulus (GO:0071364)2.84081027
88plasma membrane repair (GO:0001778)2.83422127
89regulation of RNA export from nucleus (GO:0046831)2.82523831
90negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.81123503
91positive regulation of nuclease activity (GO:0032075)2.80663081
92regulation of extracellular matrix disassembly (GO:0010715)2.80563810
93RNA localization (GO:0006403)2.80227036
94negative regulation of potassium ion transmembrane transport (GO:1901380)2.79638631
95modulation by virus of host morphology or physiology (GO:0019048)2.79225134
96stress fiber assembly (GO:0043149)2.77270014
97* gamete generation (GO:0007276)2.76890154
98chaperone-mediated protein complex assembly (GO:0051131)2.75214489
99positive regulation of Cdc42 GTPase activity (GO:0043089)2.75051849
100planar cell polarity pathway involved in neural tube closure (GO:0090179)2.73588191
101regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.73284986
102negative regulation of fatty acid transport (GO:2000192)2.72347571
103pinocytosis (GO:0006907)2.70647094
104epithelial cell differentiation involved in prostate gland development (GO:0060742)2.70638726
105barbed-end actin filament capping (GO:0051016)2.69534392
106establishment of monopolar cell polarity (GO:0061162)2.69113878
107establishment or maintenance of monopolar cell polarity (GO:0061339)2.69113878
108glucose catabolic process (GO:0006007)2.67219454
109genitalia morphogenesis (GO:0035112)2.66952534
110epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.66732710
111proline metabolic process (GO:0006560)2.65026936
112glycolytic process (GO:0006096)2.64274432
113chromatin assembly (GO:0031497)2.63927085
114sexual reproduction (GO:0019953)2.63299332
115cytoplasmic mRNA processing body assembly (GO:0033962)2.60942255
116positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.60574350
117apoptotic process involved in morphogenesis (GO:0060561)2.60031662
118spliceosomal tri-snRNP complex assembly (GO:0000244)2.59335680
119regulation of histone H3-K9 methylation (GO:0051570)2.58589051
120negative regulation of gene expression, epigenetic (GO:0045814)2.58093621
121hippo signaling (GO:0035329)2.57888094
122polarized epithelial cell differentiation (GO:0030859)2.57819887
123sperm capacitation (GO:0048240)2.56820931
124cell-substrate adherens junction assembly (GO:0007045)2.56632014
125focal adhesion assembly (GO:0048041)2.56632014
126negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.55443560
127paraxial mesoderm development (GO:0048339)2.55254360
128regulation of fatty acid beta-oxidation (GO:0031998)2.54825740
129carnitine transmembrane transport (GO:1902603)2.53595001
130fertilization (GO:0009566)2.52866461
131response to laminar fluid shear stress (GO:0034616)2.52335458
132regulation of translational termination (GO:0006449)2.52288901
133response to epidermal growth factor (GO:0070849)2.51928977
134stress granule assembly (GO:0034063)2.51790520
135regulation of mRNA stability (GO:0043488)2.51555442
136amino-acid betaine transport (GO:0015838)2.50705348
137carnitine transport (GO:0015879)2.50705348
138activation of MAPKKK activity (GO:0000185)2.50369917
139maternal placenta development (GO:0001893)2.48854682
140skin morphogenesis (GO:0043589)2.48851190
141positive regulation of blood vessel endothelial cell migration (GO:0043536)2.48636810
142cilium movement (GO:0003341)2.48540455
143negative regulation of histone methylation (GO:0031061)2.47932855
144regulation of cholesterol biosynthetic process (GO:0045540)2.47324319
145regulation of nuclease activity (GO:0032069)2.47273262
146microtubule depolymerization (GO:0007019)2.46305706
147NADPH regeneration (GO:0006740)2.46081343
148endoplasmic reticulum unfolded protein response (GO:0030968)2.45729102
149positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.45313543
150atrioventricular valve morphogenesis (GO:0003181)2.43278873
151ER-nucleus signaling pathway (GO:0006984)2.43238237
152protein export from nucleus (GO:0006611)2.42973981
153cellular response to virus (GO:0098586)2.42767752
154negative regulation of viral release from host cell (GO:1902187)2.42586495
155regulation of nucleobase-containing compound transport (GO:0032239)2.42067465
156low-density lipoprotein particle clearance (GO:0034383)2.42007809
157meiotic nuclear division (GO:0007126)2.41901105
158regulation of microtubule-based movement (GO:0060632)2.41698266
159microtubule severing (GO:0051013)2.41620051
160protein targeting to plasma membrane (GO:0072661)2.41515287
161vesicle coating (GO:0006901)2.37928613
162glucocorticoid receptor signaling pathway (GO:0042921)2.37338574
163regulation of ARF GTPase activity (GO:0032312)2.36469145
164branching involved in mammary gland duct morphogenesis (GO:0060444)2.34640115
165positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.34633570
166cortical actin cytoskeleton organization (GO:0030866)2.32582587
167convergent extension (GO:0060026)2.31838766
168histone H4 deacetylation (GO:0070933)2.31698420
169NADH metabolic process (GO:0006734)2.29453259
170positive regulation of receptor recycling (GO:0001921)2.28595402
171negative regulation of myotube differentiation (GO:0010832)2.28543314
172negative regulation of striated muscle cell differentiation (GO:0051154)2.28042614
173vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.27670713
174insulin-like growth factor receptor signaling pathway (GO:0048009)2.27150711
175regulation of extracellular matrix organization (GO:1903053)2.27122385
176apoptotic process involved in development (GO:1902742)2.26926958
177positive regulation of myotube differentiation (GO:0010831)2.26840756

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.46074604
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.76788247
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.00401995
4MYC_22102868_ChIP-Seq_BL_Human2.73862258
5* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.67924648
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.64466589
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.61404001
8KDM2B_26808549_Chip-Seq_DND41_Human2.53745741
9TCF7_22412390_ChIP-Seq_EML_Mouse2.45513534
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.42688929
11ZNF263_19887448_ChIP-Seq_K562_Human2.33067372
12ZFP281_18757296_ChIP-ChIP_E14_Mouse2.32855619
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.24309400
14LXR_22292898_ChIP-Seq_THP-1_Human2.16835574
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.14827063
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.07999670
17KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.06490917
18ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.02544451
19ZFP281_27345836_Chip-Seq_ESCs_Mouse2.01200248
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.95824590
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.91054546
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.87068666
23KDM2B_26808549_Chip-Seq_K562_Human1.86529727
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.82907922
25ELK3_25401928_ChIP-Seq_HUVEC_Human1.82489724
26VDR_21846776_ChIP-Seq_THP-1_Human1.79471919
27EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.69252640
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.63691323
29KDM2B_26808549_Chip-Seq_JURKAT_Human1.63199566
30CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.61842574
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.61616812
32RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.61233174
33DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.56252936
34P300_27058665_Chip-Seq_ZR-75-30cells_Human1.54613270
35P68_20966046_ChIP-Seq_HELA_Human1.54291296
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.51846602
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.50592455
38RACK7_27058665_Chip-Seq_MCF-7_Human1.50542007
39CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50327410
40TP53_22127205_ChIP-Seq_IMR90_Human1.48288865
41ELF1_20517297_ChIP-Seq_JURKAT_Human1.47872005
42CREB1_26743006_Chip-Seq_LNCaP_Human1.46238892
43NFIB_24661679_ChIP-Seq_LUNG_Mouse1.42131580
44SMC4_20622854_ChIP-Seq_HELA_Human1.41706056
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.41244714
46EZH2_22144423_ChIP-Seq_EOC_Human1.40611735
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39738532
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39310116
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37158326
50VDR_24763502_ChIP-Seq_THP-1_Human1.35587796
51TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.35484587
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34272600
53CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31594223
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30580214
55RUNX1_27514584_Chip-Seq_MCF-7_Human1.30383578
56CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.30227920
57TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28869904
58TBX20_22328084_ChIP-Seq_HEART_Mouse1.28842279
59TBX20_22080862_ChIP-Seq_HEART_Mouse1.28842279
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27943012
61ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.27468521
62UTX_26944678_Chip-Seq_JUKART_Human1.27004296
63NCOR1_26117541_ChIP-Seq_K562_Human1.26188527
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.25871052
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24626842
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24115406
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23906014
68ATF3_27146783_Chip-Seq_COLON_Human1.23513710
69RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22961374
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22091458
71FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21765117
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21140221
73PHF8_20622854_ChIP-Seq_HELA_Human1.20731996
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19916744
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.19020292
76BCOR_27268052_Chip-Seq_Bcells_Human1.17816727
77CTCF_27219007_Chip-Seq_Bcells_Human1.17444897
78TP63_22573176_ChIP-Seq_HFKS_Human1.16649947
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15468576
80MAF_26560356_Chip-Seq_TH2_Human1.13940946
81BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13872932
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13188148
83ELK4_26923725_Chip-Seq_MESODERM_Mouse1.12185645
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12151671
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.11057030
86MAF_26560356_Chip-Seq_TH1_Human1.10212963
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10048447
88RUNX1_22412390_ChIP-Seq_EML_Mouse1.09577632
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09537761
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.09505647
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09321059
92PKCTHETA_26484144_Chip-Seq_BREAST_Human1.09017651
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08358227
94HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08193307
95OCT4_19829295_ChIP-Seq_ESCs_Human1.08074910
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07442555
97SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07141699
98E2F1_20622854_ChIP-Seq_HELA_Human1.07073189
99E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06742026
100* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06000032
101TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05684278
102* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05283693
103STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04497852
104GATA1_19941827_ChIP-Seq_MEL_Mouse1.04319366
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04246924
106BCL6_27268052_Chip-Seq_Bcells_Human1.03902577
107E2F7_22180533_ChIP-Seq_HELA_Human1.03541076
108SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02877959
109ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02393945
110SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00995955
111PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00919371
112ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00586214
113CTCF_21964334_ChIP-Seq_BJAB-B_Human1.00250835
114CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99741814
115ISL1_27105846_Chip-Seq_CPCs_Mouse0.98664837
116MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98491206
117POU5F1_16518401_ChIP-PET_MESCs_Mouse0.98196029
118YY1_22570637_ChIP-Seq_MALME-3M_Human0.97970427
119SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.97900265
120RARB_27405468_Chip-Seq_BRAIN_Mouse0.96669692
121HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96599031
122RXR_22158963_ChIP-Seq_LIVER_Mouse0.96327729
123CLOCK_20551151_ChIP-Seq_293T_Human0.95732209
124ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95133692
125CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94542197
126TP63_17297297_ChIP-ChIP_HaCaT_Human0.94466551
127POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94273240
128TP53_23651856_ChIP-Seq_MEFs_Mouse0.94110826
129TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94081176
130SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93676236
131GATA1_19941826_ChIP-Seq_K562_Human0.93625780
132WDR5_24793694_ChIP-Seq_LNCAP_Human0.93608278
133UBF1/2_26484160_Chip-Seq_HMECs_Human0.93596265
134PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93150495

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.04026620
2MP0003705_abnormal_hypodermis_morpholog3.96760171
3MP0005451_abnormal_body_composition3.70316566
4MP0002653_abnormal_ependyma_morphology3.11681202
5MP0005076_abnormal_cell_differentiation2.86833267
6MP0005058_abnormal_lysosome_morphology2.80756742
7MP0005623_abnormal_meninges_morphology2.58962121
8MP0005409_darkened_coat_color2.51755825
9MP0003698_abnormal_male_reproductive2.45456184
10MP0004233_abnormal_muscle_weight2.43800209
11MP0009278_abnormal_bone_marrow2.39687325
12MP0001929_abnormal_gametogenesis2.24816977
13MP0008961_abnormal_basal_metabolism2.19500846
14MP0008877_abnormal_DNA_methylation2.18898136
15MP0003283_abnormal_digestive_organ2.18629819
16MP0010352_gastrointestinal_tract_polyps2.16757090
17MP0008260_abnormal_autophagy2.16410644
18MP0003172_abnormal_lysosome_physiology2.11474578
19MP0000678_abnormal_parathyroid_gland2.01158363
20MP0005670_abnormal_white_adipose1.97695780
21MP0005257_abnormal_intraocular_pressure1.97082166
22MP0000751_myopathy1.90937982
23MP0009840_abnormal_foam_cell1.90357505
24MP0001849_ear_inflammation1.89640898
25MP0000733_abnormal_muscle_development1.88645610
26MP0000537_abnormal_urethra_morphology1.81941526
27MP0003453_abnormal_keratinocyte_physiol1.80236907
28MP0004197_abnormal_fetal_growth/weight/1.62821006
29MP0010030_abnormal_orbit_morphology1.61914844
30MP0004084_abnormal_cardiac_muscle1.58257568
31MP0001730_embryonic_growth_arrest1.57928770
32MP0002210_abnormal_sex_determination1.56203862
33MP0002234_abnormal_pharynx_morphology1.53206022
34MP0004087_abnormal_muscle_fiber1.53125844
35MP0004264_abnormal_extraembryonic_tissu1.50966783
36MP0002084_abnormal_developmental_patter1.49290262
37* MP0003115_abnormal_respiratory_system1.48461611
38MP0003329_amyloid_beta_deposits1.47202880
39MP0002249_abnormal_larynx_morphology1.46834430
40MP0003566_abnormal_cell_adhesion1.46547358
41MP0000858_altered_metastatic_potential1.44851492
42MP0000566_synostosis1.44087007
43MP0002161_abnormal_fertility/fecundity1.43850266
44MP0005666_abnormal_adipose_tissue1.43512909
45MP0010630_abnormal_cardiac_muscle1.43074205
46MP0003191_abnormal_cellular_cholesterol1.40622014
47MP0003646_muscle_fatigue1.40504360
48MP0001145_abnormal_male_reproductive1.39502314
49MP0003436_decreased_susceptibility_to1.35381898
50MP0002796_impaired_skin_barrier1.34468570
51MP0002269_muscular_atrophy1.34303480
52MP0003300_gastrointestinal_ulcer1.32565435
53MP0003119_abnormal_digestive_system1.31639886
54MP0009053_abnormal_anal_canal1.30327751
55MP0004858_abnormal_nervous_system1.30165299
56MP0010307_abnormal_tumor_latency1.28915978
57MP0004185_abnormal_adipocyte_glucose1.28683526
58MP0003984_embryonic_growth_retardation1.28505767
59MP0001672_abnormal_embryogenesis/_devel1.28045069
60MP0005380_embryogenesis_phenotype1.28045069
61MP0002088_abnormal_embryonic_growth/wei1.27340524
62MP0002085_abnormal_embryonic_tissue1.26877287
63MP0005375_adipose_tissue_phenotype1.25120164
64MP0004947_skin_inflammation1.24964653
65MP0004130_abnormal_muscle_cell1.21952935
66MP0002086_abnormal_extraembryonic_tissu1.19234492
67MP0008438_abnormal_cutaneous_collagen1.16716544
68MP0010234_abnormal_vibrissa_follicle1.16213310
69MP0003111_abnormal_nucleus_morphology1.15928535
70MP0001697_abnormal_embryo_size1.14919442
71MP0000569_abnormal_digit_pigmentation1.14245488
72MP0005501_abnormal_skin_physiology1.14160368
73MP0004510_myositis1.12340959
74MP0000750_abnormal_muscle_regeneration1.11706749
75MP0002396_abnormal_hematopoietic_system1.11549648
76MP0009672_abnormal_birth_weight1.11280913
77MP0002925_abnormal_cardiovascular_devel1.07959861
78MP0002282_abnormal_trachea_morphology1.07125819
79MP0000653_abnormal_sex_gland1.07065282
80MP0000759_abnormal_skeletal_muscle1.05032151
81MP0000428_abnormal_craniofacial_morphol1.02224589
82MP0000003_abnormal_adipose_tissue1.02075046
83MP0002697_abnormal_eye_size1.01166776
84MP0003091_abnormal_cell_migration1.00187730
85MP0008995_early_reproductive_senescence0.99570142
86MP0005621_abnormal_cell_physiology0.99373700
87MP0000350_abnormal_cell_proliferation0.99196967
88MP0000266_abnormal_heart_morphology0.98293006
89* MP0002080_prenatal_lethality0.98171510
90MP0002060_abnormal_skin_morphology0.96931130
91MP0003303_peritoneal_inflammation0.96791754
92MP0003878_abnormal_ear_physiology0.95828323
93MP0005377_hearing/vestibular/ear_phenot0.95828323
94MP0003123_paternal_imprinting0.95729916
95MP0004036_abnormal_muscle_relaxation0.94799309
96MP0003279_aneurysm0.94235451
97MP0008770_decreased_survivor_rate0.92762713
98MP0003045_fibrosis0.92611465
99MP0003935_abnormal_craniofacial_develop0.92330556
100MP0002106_abnormal_muscle_physiology0.92051482
101MP0003385_abnormal_body_wall0.91428396
102MP0009703_decreased_birth_body0.90881785
103MP0009333_abnormal_splenocyte_physiolog0.89723595
104* MP0003861_abnormal_nervous_system0.89413884
105MP0002092_abnormal_eye_morphology0.89010584
106MP0009931_abnormal_skin_appearance0.87682670
107MP0002877_abnormal_melanocyte_morpholog0.86478748
108MP0005397_hematopoietic_system_phenotyp0.85970837
109MP0001545_abnormal_hematopoietic_system0.85970837
110MP0005187_abnormal_penis_morphology0.85483257
111MP0000767_abnormal_smooth_muscle0.85335467
112MP0001915_intracranial_hemorrhage0.84797669
113MP0006138_congestive_heart_failure0.83857665
114MP0004272_abnormal_basement_membrane0.83435676
115MP0005023_abnormal_wound_healing0.83314346
116MP0005330_cardiomyopathy0.82578968
117MP0004808_abnormal_hematopoietic_stem0.81989508
118MP0001293_anophthalmia0.81474056
119MP0000747_muscle_weakness0.79123228
120MP0002089_abnormal_postnatal_growth/wei0.79098924
121MP0002837_dystrophic_cardiac_calcinosis0.78292186
122MP0003567_abnormal_fetal_cardiomyocyte0.77211263
123MP0002909_abnormal_adrenal_gland0.75586911
124MP0005083_abnormal_biliary_tract0.74383253
125* MP0003942_abnormal_urinary_system0.74362161
126MP0001348_abnormal_lacrimal_gland0.74190692
127MP0002998_abnormal_bone_remodeling0.74012108
128MP0002108_abnormal_muscle_morphology0.73640227
129* MP0000534_abnormal_ureter_morphology0.73183034
130MP0002896_abnormal_bone_mineralization0.71701250
131MP0003634_abnormal_glial_cell0.71496623
132MP0005464_abnormal_platelet_physiology0.69684153
133MP0003656_abnormal_erythrocyte_physiolo0.69224927
134MP0001661_extended_life_span0.66465722
135MP0000490_abnormal_crypts_of0.66233004
136MP0005384_cellular_phenotype0.66042343
137MP0001614_abnormal_blood_vessel0.64590156
138MP0001216_abnormal_epidermal_layer0.64133596
139MP0005360_urolithiasis0.63974542
140MP0000604_amyloidosis0.63638221
141MP0004381_abnormal_hair_follicle0.63407309
142MP0002970_abnormal_white_adipose0.63049194

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)3.92514025
2Absent/shortened dynein arms (HP:0200106)3.92514025
3Hyperacusis (HP:0010780)3.79634277
4Abnormality of the lower motor neuron (HP:0002366)3.74216403
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.70107584
6Male infertility (HP:0003251)3.36415997
7Nasal polyposis (HP:0100582)3.30023132
8Cerebral aneurysm (HP:0004944)3.26910130
9Upper limb amyotrophy (HP:0009129)3.03544582
10Distal upper limb amyotrophy (HP:0007149)3.03544582
11Hand muscle atrophy (HP:0009130)3.00930885
12Infertility (HP:0000789)2.99417453
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.99403670
14Short 4th metacarpal (HP:0010044)2.99403670
15Deep venous thrombosis (HP:0002625)2.92404601
16Abnormality of the nasal mucosa (HP:0000433)2.91508963
17Renovascular hypertension (HP:0100817)2.91318911
18Distal lower limb amyotrophy (HP:0008944)2.86320106
19Heterotopia (HP:0002282)2.85780845
20Asymmetry of the thorax (HP:0001555)2.85245507
21Renal duplication (HP:0000075)2.83756594
22Difficulty climbing stairs (HP:0003551)2.80443285
23Elfin facies (HP:0004428)2.78464052
24Difficulty running (HP:0009046)2.76329938
25Shallow orbits (HP:0000586)2.72679165
26Broad face (HP:0000283)2.67275240
27Disproportionate tall stature (HP:0001519)2.67055885
28Flat acetabular roof (HP:0003180)2.65158484
29Centrally nucleated skeletal muscle fibers (HP:0003687)2.63509564
30Neoplasm of the heart (HP:0100544)2.63386472
31Protrusio acetabuli (HP:0003179)2.63046404
32Insomnia (HP:0100785)2.61817209
33Abnormality of the 4th metacarpal (HP:0010012)2.59257413
34Hemorrhage of the eye (HP:0011885)2.59125801
35Obstructive sleep apnea (HP:0002870)2.57873224
36Hyporeflexia of lower limbs (HP:0002600)2.52668044
37Ependymoma (HP:0002888)2.52047796
38Abnormality of the astrocytes (HP:0100707)2.51025758
39Astrocytoma (HP:0009592)2.51025758
40Abnormal gallbladder physiology (HP:0012438)2.41726428
41Cholecystitis (HP:0001082)2.41726428
42Reticulocytosis (HP:0001923)2.40578940
43Bladder diverticulum (HP:0000015)2.40405549
44Chronic bronchitis (HP:0004469)2.40341468
45Vertebral compression fractures (HP:0002953)2.38859400
46Increased connective tissue (HP:0009025)2.36701363
47Lymphangioma (HP:0100764)2.34917709
48Dysmetric saccades (HP:0000641)2.32721878
49Long palpebral fissure (HP:0000637)2.31046900
50Overriding aorta (HP:0002623)2.29760324
51Ankle contracture (HP:0006466)2.29257730
52Myopathic facies (HP:0002058)2.23854076
53Bowel diverticulosis (HP:0005222)2.23329111
54Distal lower limb muscle weakness (HP:0009053)2.19600828
55Abnormal respiratory motile cilium physiology (HP:0012261)2.17577268
56Abnormal respiratory epithelium morphology (HP:0012253)2.16606650
57Abnormal respiratory motile cilium morphology (HP:0005938)2.16606650
58Abnormality of the thoracic spine (HP:0100711)2.14228352
59Ankyloglossia (HP:0010296)2.13912458
60Genu recurvatum (HP:0002816)2.09949530
61Lower limb amyotrophy (HP:0007210)2.08100591
62EMG: neuropathic changes (HP:0003445)2.07111788
63Bundle branch block (HP:0011710)2.06551732
64Pointed chin (HP:0000307)2.04823485
65Thin bony cortex (HP:0002753)2.04563727
66Rhinitis (HP:0012384)2.04059878
67Increased nuchal translucency (HP:0010880)2.04036302
68Macroorchidism (HP:0000053)2.01157269
69Asymmetric septal hypertrophy (HP:0001670)1.99395516
70Amyotrophic lateral sclerosis (HP:0007354)1.99078283
71Exercise-induced myalgia (HP:0003738)1.98414518
72Flat cornea (HP:0007720)1.97881170
73Cervical subluxation (HP:0003308)1.96673237
74Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.96047417
75Aneurysm (HP:0002617)1.95633402
76Mitral valve prolapse (HP:0001634)1.94422352
77Mitral regurgitation (HP:0001653)1.91422384
78Exercise-induced muscle cramps (HP:0003710)1.90205443
79Ulnar bowing (HP:0003031)1.89971420
80Pseudobulbar signs (HP:0002200)1.88691704
81Spinal rigidity (HP:0003306)1.87818426
82Abnormality of the fingertips (HP:0001211)1.87532642
83Cerebral inclusion bodies (HP:0100314)1.87040158
84Mildly elevated creatine phosphokinase (HP:0008180)1.86986459
85Megalocornea (HP:0000485)1.86544598
86Hallux valgus (HP:0001822)1.86184260
87Type 1 muscle fiber predominance (HP:0003803)1.85574876
88Fibroma (HP:0010614)1.85531262
89Advanced eruption of teeth (HP:0006288)1.85393419
90Rectal prolapse (HP:0002035)1.85369649
91Deviation of the hallux (HP:0010051)1.84598233
92Fragile skin (HP:0001030)1.84441687
93Thin ribs (HP:0000883)1.83896385
94Segmental peripheral demyelination/remyelination (HP:0003481)1.83727690
95Abnormality of oral frenula (HP:0000190)1.82990976
96Increased variability in muscle fiber diameter (HP:0003557)1.82037828
97Bowel incontinence (HP:0002607)1.81145302
98Abnormality of the calcaneus (HP:0008364)1.80730628
99Truncus arteriosus (HP:0001660)1.79861091
100Hyperparathyroidism (HP:0000843)1.79492821
101Patellar dislocation (HP:0002999)1.79391025
102Enlarged penis (HP:0000040)1.79102836
103Biconcave vertebral bodies (HP:0004586)1.78839499
104Turricephaly (HP:0000262)1.77776417
105Short phalanx of the thumb (HP:0009660)1.75335065
106Broad metatarsal (HP:0001783)1.74431082
107High pitched voice (HP:0001620)1.74315841
108Fibrous tissue neoplasm (HP:0012316)1.74051810
109Arnold-Chiari malformation (HP:0002308)1.74021741
110Achilles tendon contracture (HP:0001771)1.73373845
111Short nail (HP:0001799)1.73228184
112Long toe (HP:0010511)1.72070866
113Blue sclerae (HP:0000592)1.71654138
114Cellulitis (HP:0100658)1.71480891
115Thoracic kyphosis (HP:0002942)1.70730893
116Polycythemia (HP:0001901)1.69333085
117Selective tooth agenesis (HP:0001592)1.68872161
118Buphthalmos (HP:0000557)1.68446687
119Myoglobinuria (HP:0002913)1.67601337
120Abnormality of the distal phalanx of the thumb (HP:0009617)1.67128399
121Deep palmar crease (HP:0006191)1.66995811
122Abnormal large intestine physiology (HP:0012700)1.66690240
123Sudden death (HP:0001699)1.66316162
124Easy fatigability (HP:0003388)1.65158715
125Aortic aneurysm (HP:0004942)1.64711887
126Trismus (HP:0000211)1.63979809
127Atelectasis (HP:0100750)1.63679344
128Trigonocephaly (HP:0000243)1.62501042
129Dislocated radial head (HP:0003083)1.61931909
130Premature skin wrinkling (HP:0100678)1.61615032
131Increased density of long bones (HP:0006392)1.61595797
132Abnormal ossification of hand bones (HP:0005921)1.61238834
133Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.60159872
134Abnormality of reticulocytes (HP:0004312)1.58894533
135Hyperthyroidism (HP:0000836)1.57872297
136Abnormality of the Achilles tendon (HP:0005109)1.57752017
137Glioma (HP:0009733)1.57653392
138Cupped ribs (HP:0000887)1.57006663
139Abnormality of skeletal muscle fiber size (HP:0012084)1.56578466
140Broad palm (HP:0001169)1.55697575
141Stridor (HP:0010307)1.55047050
142Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.54619832
143Abnormality of carpal bone ossification (HP:0006257)1.54099036
144Dilatation of the ascending aorta (HP:0005111)1.54092503
145Bronchomalacia (HP:0002780)1.54030429
146Abnormality of the tricuspid valve (HP:0001702)1.53885151
147Premature rupture of membranes (HP:0001788)1.53828801
148Abnormality of the diencephalon (HP:0010662)1.53640754
149Obsessive-compulsive behavior (HP:0000722)1.53592948
150Back pain (HP:0003418)1.53334532
151Abnormality of the distal phalanges of the toes (HP:0010182)1.52743891
152Germ cell neoplasia (HP:0100728)1.52262977
153Subacute progressive viral hepatitis (HP:0006572)1.52249681
154Muscle fiber splitting (HP:0003555)1.51490138
155Decreased motor nerve conduction velocity (HP:0003431)1.51424164
156Supranuclear gaze palsy (HP:0000605)1.51037112
157Rhizomelia (HP:0008905)1.50832039
158Hypercortisolism (HP:0001578)1.50770244
159Foot dorsiflexor weakness (HP:0009027)1.50612680
160Metaphyseal cupping (HP:0003021)1.50145584
161Coxa vara (HP:0002812)1.49995136
162Sacral dimple (HP:0000960)1.49698009
163Spinal cord lesions (HP:0100561)1.49484939
164Syringomyelia (HP:0003396)1.49484939
165Precocious puberty (HP:0000826)1.49082990
166Truncal obesity (HP:0001956)1.48945702
167Short humerus (HP:0005792)1.46797928
168Urethral obstruction (HP:0000796)1.45927591

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.31940865
2PRKD34.02913581
3SMG13.82937948
4PDK43.42144002
5PDK33.42144002
6EEF2K3.39865692
7CDK123.21382336
8TESK13.11011762
9PKN23.01499707
10MAP3K102.97630774
11PRPF4B2.97388798
12IRAK32.29317261
13RIPK12.07876089
14TYRO32.07680102
15TTN2.03771097
16NEK21.94300116
17PDGFRA1.74295027
18PDK21.71641263
19CAMK1G1.70060177
20ERN11.65081321
21PTK61.58971700
22MTOR1.54937547
23MAP2K31.51446069
24STK381.42005855
25* ICK1.39481263
26BMX1.34664541
27SIK11.30394708
28DYRK1B1.26672001
29CAMK1D1.23626778
30NEK11.21528175
31PAK41.20787554
32ALK1.18984911
33LATS21.18837439
34PTK2B1.17470756
35TAOK21.17154391
36TAOK11.14449971
37NME21.11089162
38LATS11.09314207
39NTRK11.09307217
40MAP3K111.07707679
41DDR21.05454424
42MAP3K131.03094693
43PAK21.01082104
44PNCK1.00702595
45RIPK40.99813737
46PAK60.99020042
47DMPK0.98706572
48MST1R0.96002142
49SIK20.95506788
50MAP3K10.93745012
51EPHB20.88732892
52MAP3K30.86142934
53CDK60.85997251
54MAP3K90.85467325
55MAP3K60.84245871
56CDC70.83294708
57LMTK20.82829294
58PTK20.82393594
59ARAF0.81505359
60CDK40.80421166
61BRD40.78662453
62FGFR30.78644730
63SCYL20.77067920
64HIPK20.74953936
65STK30.74843716
66KSR20.74404764
67MAPK110.70244299
68RET0.70022520
69BRAF0.69347631
70CAMKK10.69198854
71PDGFRB0.68164586
72MAP4K10.66457775
73LRRK20.65305259
74FGFR10.64672743
75WNK10.63238745
76MARK20.60789887
77CHEK10.58709268
78MAP3K70.58502437
79PASK0.58118386
80RPS6KA10.57991906
81SIK30.57522068
82MAP2K20.57388245
83WNK40.56748219
84PDK10.55929157
85CDC42BPA0.55448080
86EPHB10.53662888
87TTK0.53281270
88FGFR40.53075797
89RPS6KA20.52672419
90IRAK40.52426969
91STK100.52203864
92SGK30.52060550
93MAP3K20.51918539
94ZAP700.51561106
95NTRK20.51307486
96PRKG20.48699499
97PRKAA10.47819445
98IRAK20.47348605
99MET0.45241368
100KSR10.44977080
101STK110.44634924
102PRKCH0.44194970
103MAPK120.43784122
104TYK20.43723907
105CDK90.43491136
106ILK0.42912782
107CLK10.42573964
108CDK20.42525696
109MAP3K80.41426161
110PDPK10.41141080
111ERBB20.41042099
112UHMK10.40688255
113TBK10.40174976
114PHKG10.39848518
115PHKG20.39848518
116RPS6KB20.38660447
117PAK10.38517104
118RPS6KA60.37990512
119CDK70.37292779
120FGFR20.37059744
121AKT20.36373581
122PRKD20.35805165
123TESK20.35251829
124MOS0.34872830
125DAPK20.34628326
126MAPKAPK20.33943692
127CDK11A0.33719889
128PRKD10.33118839
129MAPK80.32529648
130CSNK1D0.32482320
131DYRK30.32140392
132RPS6KC10.31935441
133RPS6KL10.31935441
134ATR0.31828510
135EPHA20.31701117
136MAPK100.31050375
137GSK3B0.28727312
138MAPK10.27713706
139CSNK1E0.25851965
140CDK10.25083809

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.18210491
2Fatty acid biosynthesis_Homo sapiens_hsa000612.10549971
3Dorso-ventral axis formation_Homo sapiens_hsa043201.94134069
4mTOR signaling pathway_Homo sapiens_hsa041501.79146647
5Thyroid cancer_Homo sapiens_hsa052161.73784657
6Central carbon metabolism in cancer_Homo sapiens_hsa052301.68859679
7Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.65678785
8Glucagon signaling pathway_Homo sapiens_hsa049221.64822310
9Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.64296224
10Lysine degradation_Homo sapiens_hsa003101.61386900
11Pentose phosphate pathway_Homo sapiens_hsa000301.59857271
12Prion diseases_Homo sapiens_hsa050201.59743263
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58683701
14Chronic myeloid leukemia_Homo sapiens_hsa052201.54975954
15Basal cell carcinoma_Homo sapiens_hsa052171.53476461
16Thyroid hormone signaling pathway_Homo sapiens_hsa049191.52040722
17Notch signaling pathway_Homo sapiens_hsa043301.49491945
18mRNA surveillance pathway_Homo sapiens_hsa030151.44472903
19Hedgehog signaling pathway_Homo sapiens_hsa043401.42296296
20VEGF signaling pathway_Homo sapiens_hsa043701.39931168
21Estrogen signaling pathway_Homo sapiens_hsa049151.38671146
22Fructose and mannose metabolism_Homo sapiens_hsa000511.38548215
23Carbohydrate digestion and absorption_Homo sapiens_hsa049731.32984876
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32619774
25Adherens junction_Homo sapiens_hsa045201.32370443
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31007414
27AMPK signaling pathway_Homo sapiens_hsa041521.30682463
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.30317253
29Longevity regulating pathway - mammal_Homo sapiens_hsa042111.28832476
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.26431487
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.25099883
32Endometrial cancer_Homo sapiens_hsa052131.24922454
33Insulin resistance_Homo sapiens_hsa049311.24135888
34Hippo signaling pathway_Homo sapiens_hsa043901.23766384
35Proteoglycans in cancer_Homo sapiens_hsa052051.22458630
36Glioma_Homo sapiens_hsa052141.21904829
37Focal adhesion_Homo sapiens_hsa045101.21791675
38Insulin signaling pathway_Homo sapiens_hsa049101.20087139
39Oocyte meiosis_Homo sapiens_hsa041141.14811859
40Adipocytokine signaling pathway_Homo sapiens_hsa049201.14512759
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12918140
42Type II diabetes mellitus_Homo sapiens_hsa049301.11566734
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11091380
44Galactose metabolism_Homo sapiens_hsa000521.10772338
45Nitrogen metabolism_Homo sapiens_hsa009101.10656274
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09992767
47Non-small cell lung cancer_Homo sapiens_hsa052231.08255633
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.07780403
49Bladder cancer_Homo sapiens_hsa052191.06072704
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05162948
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03735611
52Neurotrophin signaling pathway_Homo sapiens_hsa047221.03036752
53Small cell lung cancer_Homo sapiens_hsa052221.01905425
54MicroRNAs in cancer_Homo sapiens_hsa052061.01372847
55Dilated cardiomyopathy_Homo sapiens_hsa054141.01306659
56Choline metabolism in cancer_Homo sapiens_hsa052311.00403052
57GnRH signaling pathway_Homo sapiens_hsa049121.00395322
58Viral myocarditis_Homo sapiens_hsa054160.98356415
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.97766010
60Renal cell carcinoma_Homo sapiens_hsa052110.96618894
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95926680
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95792803
63Pyruvate metabolism_Homo sapiens_hsa006200.94759349
64Acute myeloid leukemia_Homo sapiens_hsa052210.94074039
65Colorectal cancer_Homo sapiens_hsa052100.94001201
66Biosynthesis of amino acids_Homo sapiens_hsa012300.92608983
67Hepatitis B_Homo sapiens_hsa051610.92190666
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92096897
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91964297
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90696283
71HIF-1 signaling pathway_Homo sapiens_hsa040660.90020366
72Carbon metabolism_Homo sapiens_hsa012000.89898370
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.89122342
74PPAR signaling pathway_Homo sapiens_hsa033200.88809325
75Tight junction_Homo sapiens_hsa045300.88607341
76Hepatitis C_Homo sapiens_hsa051600.86752982
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85952843
78Selenocompound metabolism_Homo sapiens_hsa004500.85724413
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83991449
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.83095075
81RNA transport_Homo sapiens_hsa030130.81996301
82Apoptosis_Homo sapiens_hsa042100.81829447
83HTLV-I infection_Homo sapiens_hsa051660.81320123
84Wnt signaling pathway_Homo sapiens_hsa043100.80789735
85Endocytosis_Homo sapiens_hsa041440.79431940
86Bile secretion_Homo sapiens_hsa049760.79346033
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77553818
88Fatty acid metabolism_Homo sapiens_hsa012120.76847306
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76783921
90Inositol phosphate metabolism_Homo sapiens_hsa005620.76079839
91ECM-receptor interaction_Homo sapiens_hsa045120.75981484
92Osteoclast differentiation_Homo sapiens_hsa043800.74770494
93Amoebiasis_Homo sapiens_hsa051460.73155253
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73042975
95ErbB signaling pathway_Homo sapiens_hsa040120.68985240
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68779104
97Gap junction_Homo sapiens_hsa045400.68715859
98Long-term potentiation_Homo sapiens_hsa047200.68572319
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.68306848
100Pancreatic cancer_Homo sapiens_hsa052120.67680305
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.67585571
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67128373
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67022563
104Axon guidance_Homo sapiens_hsa043600.66803379
105Melanogenesis_Homo sapiens_hsa049160.66592600
106Shigellosis_Homo sapiens_hsa051310.64070023
107Viral carcinogenesis_Homo sapiens_hsa052030.63368219
108B cell receptor signaling pathway_Homo sapiens_hsa046620.62503634
109Influenza A_Homo sapiens_hsa051640.62416591
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62358839
111Oxytocin signaling pathway_Homo sapiens_hsa049210.61813778
112Gastric acid secretion_Homo sapiens_hsa049710.61417782
113Vibrio cholerae infection_Homo sapiens_hsa051100.61290351
114Fat digestion and absorption_Homo sapiens_hsa049750.60953786
115Glycerolipid metabolism_Homo sapiens_hsa005610.60797454
116Renin secretion_Homo sapiens_hsa049240.60313469
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59200429
118Salmonella infection_Homo sapiens_hsa051320.58591029
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58067778
120Pathways in cancer_Homo sapiens_hsa052000.58036146
121Arginine biosynthesis_Homo sapiens_hsa002200.57924051
122Rap1 signaling pathway_Homo sapiens_hsa040150.57884258
123Toxoplasmosis_Homo sapiens_hsa051450.57023434
124T cell receptor signaling pathway_Homo sapiens_hsa046600.56585073
125FoxO signaling pathway_Homo sapiens_hsa040680.55987729
126Protein digestion and absorption_Homo sapiens_hsa049740.55158316
127Prolactin signaling pathway_Homo sapiens_hsa049170.55057242
128Prostate cancer_Homo sapiens_hsa052150.54806715
129TNF signaling pathway_Homo sapiens_hsa046680.54112760
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49541523
131N-Glycan biosynthesis_Homo sapiens_hsa005100.47957029
132Leishmaniasis_Homo sapiens_hsa051400.47610289

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