BAG5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.73659850
2multicellular organism reproduction (GO:0032504)9.44264200
3cilium or flagellum-dependent cell motility (GO:0001539)9.43130539
4plasma membrane fusion (GO:0045026)9.41166374
5cell-cell recognition (GO:0009988)9.35090775
6axonemal dynein complex assembly (GO:0070286)9.15187273
7epithelial cilium movement (GO:0003351)8.95598302
8spermatid development (GO:0007286)8.88428428
9motile cilium assembly (GO:0044458)8.71360602
10regulation of cilium movement (GO:0003352)8.38599650
11reproduction (GO:0000003)8.02349449
12cilium movement (GO:0003341)7.29891869
13piRNA metabolic process (GO:0034587)6.82702409
14male meiosis (GO:0007140)6.71806808
15synaptonemal complex organization (GO:0070193)6.70746886
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.66988248
17synaptonemal complex assembly (GO:0007130)6.48447545
18single fertilization (GO:0007338)6.48108599
19negative regulation of inclusion body assembly (GO:0090084)6.47697473
20sperm capacitation (GO:0048240)6.14336727
21spermatogenesis (GO:0007283)5.81576866
22male gamete generation (GO:0048232)5.79925451
23microtubule depolymerization (GO:0007019)5.79857783
24fertilization (GO:0009566)5.40327608
25gamete generation (GO:0007276)5.31886249
26calcium ion-dependent exocytosis (GO:0017156)5.24372345
27organic cation transport (GO:0015695)5.18101218
28ribosome assembly (GO:0042255)4.96132244
29regulation of centriole replication (GO:0046599)4.92297876
30microtubule severing (GO:0051013)4.89263925
31regulation of microtubule-based movement (GO:0060632)4.84173454
32germ cell development (GO:0007281)4.81059294
33male meiosis I (GO:0007141)4.80437413
34nuclear pore complex assembly (GO:0051292)4.76871264
35cellular process involved in reproduction in multicellular organism (GO:0022412)4.75993701
36ventricular system development (GO:0021591)4.75461839
37cell recognition (GO:0008037)4.63170162
38DNA double-strand break processing (GO:0000729)4.50164360
39* regulation of inclusion body assembly (GO:0090083)4.46448832
40chromosome organization involved in meiosis (GO:0070192)4.40303400
41nuclear pore organization (GO:0006999)4.33475106
42seminiferous tubule development (GO:0072520)4.31299812
43glycerol ether metabolic process (GO:0006662)4.26629724
44spermatid nucleus differentiation (GO:0007289)4.26133303
45DNA methylation involved in gamete generation (GO:0043046)4.23251408
46chromosome condensation (GO:0030261)4.22524948
47meiotic nuclear division (GO:0007126)4.22240640
48left/right pattern formation (GO:0060972)4.17238417
49multicellular organismal reproductive process (GO:0048609)4.14385555
50protein polyglutamylation (GO:0018095)4.12060469
51meiosis I (GO:0007127)4.08364534
52DNA packaging (GO:0006323)4.08301406
53chaperone-mediated protein complex assembly (GO:0051131)3.99823256
54ether metabolic process (GO:0018904)3.93657693
55protein refolding (GO:0042026)3.84483558
56monoubiquitinated protein deubiquitination (GO:0035520)3.84350007
57protein localization to cilium (GO:0061512)3.71477400
58regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.68564469
59mitotic metaphase plate congression (GO:0007080)3.66076261
60regulation of DNA endoreduplication (GO:0032875)3.64690988
61single strand break repair (GO:0000012)3.54765934
62double-strand break repair via nonhomologous end joining (GO:0006303)3.53685609
63non-recombinational repair (GO:0000726)3.53685609
64pore complex assembly (GO:0046931)3.50284194
65negative regulation of DNA recombination (GO:0045910)3.49459138
66metaphase plate congression (GO:0051310)3.48165565
67GTP biosynthetic process (GO:0006183)3.47185952
68regulation of spindle checkpoint (GO:0090231)3.44678562
69meiotic cell cycle (GO:0051321)3.37547600
70multicellular organismal development (GO:0007275)3.35123223
71keratinocyte development (GO:0003334)3.30057524
72polyamine biosynthetic process (GO:0006596)3.28532081
73nucleoside diphosphate phosphorylation (GO:0006165)3.26729918
74DNA deamination (GO:0045006)3.21619767
75polyol catabolic process (GO:0046174)3.19354129
76regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.18859274
77regulation of mitotic spindle checkpoint (GO:1903504)3.18859274
78establishment of integrated proviral latency (GO:0075713)3.15183014
79UTP biosynthetic process (GO:0006228)3.14099895
80DNA ligation (GO:0006266)3.12430363
81protein K11-linked deubiquitination (GO:0035871)3.09044214
82replication fork processing (GO:0031297)3.07034728
83ribonucleoprotein complex disassembly (GO:0032988)3.06650815
84sexual reproduction (GO:0019953)3.05647819
85nucleus organization (GO:0006997)3.05505939
86protein K6-linked ubiquitination (GO:0085020)3.05177066
87microtubule polymerization or depolymerization (GO:0031109)3.04037501
88regulation of centrosome duplication (GO:0010824)3.03404640
89protein targeting to Golgi (GO:0000042)3.03132484
90guanosine-containing compound biosynthetic process (GO:1901070)3.02115857
91CENP-A containing nucleosome assembly (GO:0034080)3.01271619
92regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.00374954
93response to X-ray (GO:0010165)3.00105510
94intraciliary transport (GO:0042073)2.98541567
95sequestering of actin monomers (GO:0042989)2.97644835
96chromatin remodeling at centromere (GO:0031055)2.96720930
97mitotic G2/M transition checkpoint (GO:0044818)2.95615689
98DNA strand elongation involved in DNA replication (GO:0006271)2.94687910
99glycolytic process (GO:0006096)2.94648321
100establishment of chromosome localization (GO:0051303)2.94615695
101mitotic sister chromatid cohesion (GO:0007064)2.94397723
102organelle disassembly (GO:1903008)2.92786545
103interferon-gamma secretion (GO:0072643)2.91787984
104kinetochore organization (GO:0051383)2.91555114
105sister chromatid cohesion (GO:0007062)2.89210738
106regulation of mRNA splicing, via spliceosome (GO:0048024)2.88573997
107DNA unwinding involved in DNA replication (GO:0006268)2.87684406
108somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.86915908
109isotype switching (GO:0045190)2.86915908
110somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.86915908
111DNA strand elongation (GO:0022616)2.86623284
112DNA replication checkpoint (GO:0000076)2.84341252
113negative regulation of DNA-dependent DNA replication (GO:2000104)2.83567330
114establishment of protein localization to Golgi (GO:0072600)2.83472574
115retrograde transport, vesicle recycling within Golgi (GO:0000301)2.82584208
116histone mRNA metabolic process (GO:0008334)2.81587009
117meiotic cell cycle process (GO:1903046)2.81181880
118centriole replication (GO:0007099)2.80650331
119histone H2A acetylation (GO:0043968)2.79877075
120histone exchange (GO:0043486)2.79705484
121rRNA methylation (GO:0031167)2.79443706
122UTP metabolic process (GO:0046051)2.79361433
123mitotic nuclear envelope disassembly (GO:0007077)2.77768154
124regulation of centrosome cycle (GO:0046605)2.76971428
125genitalia morphogenesis (GO:0035112)2.75893325
126rRNA modification (GO:0000154)2.74748762
127axoneme assembly (GO:0035082)2.74450975
128postreplication repair (GO:0006301)2.74435139
129microtubule-based movement (GO:0007018)2.72598271
130cilium organization (GO:0044782)2.70476594
131membrane disassembly (GO:0030397)2.67723369
132nuclear envelope disassembly (GO:0051081)2.67723369
133maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.67378288
134DNA catabolic process, exonucleolytic (GO:0000738)2.66980706
135telomere maintenance via telomerase (GO:0007004)2.66839061
136DNA replication-dependent nucleosome assembly (GO:0006335)2.66196806
137DNA replication-dependent nucleosome organization (GO:0034723)2.66196806
138cilium morphogenesis (GO:0060271)2.66172682
139peptidyl-threonine dephosphorylation (GO:0035970)2.65042173
140regulation of helicase activity (GO:0051095)2.64684004
141RNA-dependent DNA replication (GO:0006278)2.63153087
142CTP metabolic process (GO:0046036)2.61390465
143CTP biosynthetic process (GO:0006241)2.61390465
144cilium assembly (GO:0042384)2.58643690
145gene silencing by RNA (GO:0031047)2.58061421
146regulation of chromosome segregation (GO:0051983)2.57439005
147negative regulation of fibroblast apoptotic process (GO:2000270)2.56728870
148alditol metabolic process (GO:0019400)2.55777327
149mitochondrial fission (GO:0000266)2.55170825
150lactate metabolic process (GO:0006089)2.54100067
151termination of RNA polymerase II transcription (GO:0006369)2.53528157
152ER overload response (GO:0006983)2.52796809
153positive regulation of mRNA processing (GO:0050685)2.51437393
154sister chromatid segregation (GO:0000819)2.51015551
155positive regulation of macrophage activation (GO:0043032)2.50865157
156protein K11-linked ubiquitination (GO:0070979)2.49916856
157viral mRNA export from host cell nucleus (GO:0046784)2.48981423
158negative regulation of organelle assembly (GO:1902116)2.48151612
159spindle checkpoint (GO:0031577)2.47968764
160kinetochore assembly (GO:0051382)2.47828304
161protein localization to chromosome, centromeric region (GO:0071459)2.47161670
162regulation of cilium assembly (GO:1902017)2.46977493
163RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.46969950
164RNA export from nucleus (GO:0006405)2.46873388
165L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.46829441
166mitochondrial RNA metabolic process (GO:0000959)2.46288955
167protein complex localization (GO:0031503)2.46252690
168regulation of mRNA processing (GO:0050684)2.45786304
169ATP-dependent chromatin remodeling (GO:0043044)2.45661692
170cellular component assembly involved in morphogenesis (GO:0010927)2.45394457
171somatic recombination of immunoglobulin gene segments (GO:0016447)2.45304473
172purine nucleobase biosynthetic process (GO:0009113)2.45239414
173pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.45203798
174positive regulation of macroautophagy (GO:0016239)2.44526289
175mRNA export from nucleus (GO:0006406)2.43578598
176telomere maintenance via semi-conservative replication (GO:0032201)2.43070569
177histone mRNA catabolic process (GO:0071044)2.42879662
178pre-miRNA processing (GO:0031054)2.41219023
179DNA conformation change (GO:0071103)2.41034139
180fusion of sperm to egg plasma membrane (GO:0007342)12.2078661
181sperm motility (GO:0030317)12.0147350
182cell wall macromolecule metabolic process (GO:0044036)10.6192462
183cell wall macromolecule catabolic process (GO:0016998)10.6192462
184acrosome reaction (GO:0007340)10.5918339
185sperm-egg recognition (GO:0035036)10.5231516
186acrosome assembly (GO:0001675)10.1599142

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.67951322
2EZH2_22144423_ChIP-Seq_EOC_Human4.34163195
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.90873168
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.84011227
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.18883140
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.14526743
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.86592552
8ELK1_19687146_ChIP-ChIP_HELA_Human2.79974043
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.79868007
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.75384757
11* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.73065704
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.58189711
13VDR_22108803_ChIP-Seq_LS180_Human2.50757420
14PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.46189083
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.31267916
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29742089
17FUS_26573619_Chip-Seq_HEK293_Human2.28627668
18PADI4_21655091_ChIP-ChIP_MCF-7_Human2.20372363
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.16965985
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15192180
21ZNF274_21170338_ChIP-Seq_K562_Hela2.14233592
22STAT6_21828071_ChIP-Seq_BEAS2B_Human2.12543501
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.11772483
24AR_21909140_ChIP-Seq_LNCAP_Human2.07294242
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01521823
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.3128219
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96646368
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.90823725
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.89199051
30EWS_26573619_Chip-Seq_HEK293_Human1.89018221
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.86936434
32FOXM1_23109430_ChIP-Seq_U2OS_Human1.85822538
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.80765272
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79027753
35GATA1_26923725_Chip-Seq_HPCs_Mouse1.77216547
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76308727
37VDR_23849224_ChIP-Seq_CD4+_Human1.76135360
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75310802
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73813928
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.66676059
41SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.66010622
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.64304798
43EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.64100023
44P300_19829295_ChIP-Seq_ESCs_Human1.63807850
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61420485
46TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.57838479
47* MYC_18555785_ChIP-Seq_MESCs_Mouse1.55836330
48IGF1R_20145208_ChIP-Seq_DFB_Human1.54561412
49GATA3_21867929_ChIP-Seq_CD8_Mouse1.53526887
50FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50224180
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48743191
52ER_23166858_ChIP-Seq_MCF-7_Human1.48146159
53KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.46753122
54SOX2_22085726_ChIP-Seq_NPCs_Mouse1.45739983
55GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.45678889
56WDR5_24793694_ChIP-Seq_LNCAP_Human1.45521659
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45257849
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43651757
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42829144
60STAT1_17558387_ChIP-Seq_HELA_Human1.40786211
61NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40566248
62REST_21632747_ChIP-Seq_MESCs_Mouse1.39531870
63DCP1A_22483619_ChIP-Seq_HELA_Human1.39384568
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37432638
65KAP1_22055183_ChIP-Seq_ESCs_Mouse1.36488174
66RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.36462264
67* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.34267539
68MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.33828423
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.32054337
70ELK4_26923725_Chip-Seq_MESODERM_Mouse1.31768738
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31589454
72FOXP3_21729870_ChIP-Seq_TREG_Human1.30785051
73P53_21459846_ChIP-Seq_SAOS-2_Human1.30749318
74GBX2_23144817_ChIP-Seq_PC3_Human1.30415708
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30334296
76MYC_19030024_ChIP-ChIP_MESCs_Mouse1.29236667
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28989088
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28301111
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27767845
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26907596
81CBP_20019798_ChIP-Seq_JUKART_Human1.26907596
82YY1_22570637_ChIP-Seq_MALME-3M_Human1.24930921
83ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23552916
84SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23222508
85LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.22576031
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19722638
87FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18822994
88ERG_20517297_ChIP-Seq_VCAP_Human1.18748790
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.18528194
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18526080
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16759178
92SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16493663
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.16091886
94CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14862732
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14727515
96* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.14635612
97CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14410392
98SMAD4_21799915_ChIP-Seq_A2780_Human1.14128910
99GATA3_21867929_ChIP-Seq_TH1_Mouse1.14099316
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14062194
101ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11024220
102CBX2_27304074_Chip-Seq_ESCs_Mouse1.10476320
103TET1_21451524_ChIP-Seq_MESCs_Mouse1.09955792
104KDM2B_26808549_Chip-Seq_REH_Human1.09840099
105* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09601930
106RUNX1_26923725_Chip-Seq_HPCs_Mouse1.07246456
107AR_25329375_ChIP-Seq_VCAP_Human1.07061752
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06492744
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06181730
110TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06107956
111SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05961046
112HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05680356
113* GABP_19822575_ChIP-Seq_HepG2_Human1.05483168
114SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04820504
115MYC_18940864_ChIP-ChIP_HL60_Human1.01399827
116CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00329992
117CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00321325
118EZH2_27294783_Chip-Seq_NPCs_Mouse1.00150798
119SALL4_22934838_ChIP-ChIP_CD34+_Human0.99958786
120SPI1_26923725_Chip-Seq_HPCs_Mouse0.99809650
121SMAD3_21741376_ChIP-Seq_EPCs_Human0.99785959
122ELF1_20517297_ChIP-Seq_JURKAT_Human0.99747209
123PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99540697
124TAF15_26573619_Chip-Seq_HEK293_Human0.99188416
125CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98933477
126WT1_19549856_ChIP-ChIP_CCG9911_Human0.98383204
127RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98035470
128NFE2_27457419_Chip-Seq_LIVER_Mouse0.97910881
129RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97549285
130FLI1_21867929_ChIP-Seq_CD8_Mouse0.97337581
131STAT3_23295773_ChIP-Seq_U87_Human0.95936202
132PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95512211
133LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95188113
134CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94325557
135* NANOG_16153702_ChIP-ChIP_HESCs_Human0.94207160
136SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.94068742
137RARA_24833708_ChIP-Seq_LIVER_Mouse0.94024516
138HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92815699
139* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92212662
140POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92161216
141TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92161216
142AHR_22903824_ChIP-Seq_MCF-7_Human0.91582237
143CTCF_20526341_ChIP-Seq_ESCs_Human0.91465752
144GF1_26923725_Chip-Seq_HPCs_Mouse0.91388660
145CDX2_22108803_ChIP-Seq_LS180_Human0.91115539
146RAD21_21589869_ChIP-Seq_MESCs_Mouse0.91107247
147ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90939142
148* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90603086
149ELK1_22589737_ChIP-Seq_MCF10A_Human0.90545052
150TTF2_22483619_ChIP-Seq_HELA_Human0.90113877
151CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.90007668
152TFEB_21752829_ChIP-Seq_HELA_Human0.89596708
153ARNT_22903824_ChIP-Seq_MCF-7_Human0.89344932
154KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89042396
155SOX2_21211035_ChIP-Seq_LN229_Human0.88912013
156* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.86098232
157TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84713638
158CRX_20693478_ChIP-Seq_RETINA_Mouse0.84174469
159PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83863583
160RXRA_24833708_ChIP-Seq_LIVER_Mouse0.83743772
161SUZ12_27294783_Chip-Seq_NPCs_Mouse0.83132522
162EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.82715842
163SOX9_26525672_Chip-Seq_HEART_Mouse0.81678943
164ETS1_20019798_ChIP-Seq_JURKAT_Human0.80760379
165SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80698756
166PHF8_20622854_ChIP-Seq_HELA_Human0.80180070
167CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79457707
168PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76750187
169* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.76713296
170TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76600375
171ESET_19884257_ChIP-Seq_ESCs_Mouse0.76529679
172NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.76441986
173YY1_21170310_ChIP-Seq_MESCs_Mouse0.75254322
174NANOG_18555785_Chip-Seq_ESCs_Mouse0.75052123
175ZFP57_27257070_Chip-Seq_ESCs_Mouse0.74136971

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.47796197
2MP0001929_abnormal_gametogenesis5.09950973
3MP0008877_abnormal_DNA_methylation4.36217464
4MP0002210_abnormal_sex_determination3.24772839
5MP0002161_abnormal_fertility/fecundity3.01601947
6MP0001145_abnormal_male_reproductive2.77249590
7MP0000653_abnormal_sex_gland2.41956045
8MP0010352_gastrointestinal_tract_polyps2.34874744
9MP0002653_abnormal_ependyma_morphology2.31066665
10MP0010234_abnormal_vibrissa_follicle2.28427710
11MP0009697_abnormal_copulation2.21476799
12MP0005410_abnormal_fertilization14.4101733
13MP0005423_abnormal_somatic_nervous1.94209370
14MP0010678_abnormal_skin_adnexa1.91630029
15MP0003718_maternal_effect1.83155932
16MP0005248_abnormal_Harderian_gland1.81863426
17MP0000647_abnormal_sebaceous_gland1.77719469
18MP0003646_muscle_fatigue1.76480746
19MP0002160_abnormal_reproductive_system1.74391401
20MP0000383_abnormal_hair_follicle1.71301060
21MP0008058_abnormal_DNA_repair1.71082698
22MP0003880_abnormal_central_pattern1.66156373
23MP0005187_abnormal_penis_morphology1.66091806
24MP0002009_preneoplasia1.62202573
25MP0004233_abnormal_muscle_weight1.59716713
26MP0005670_abnormal_white_adipose1.59639470
27MP0003221_abnormal_cardiomyocyte_apopto1.56500476
28MP0000569_abnormal_digit_pigmentation1.47091065
29MP0003941_abnormal_skin_development1.45561777
30MP0000427_abnormal_hair_cycle1.45079798
31MP0004197_abnormal_fetal_growth/weight/1.42534963
32MP0008789_abnormal_olfactory_epithelium1.41262107
33MP0004782_abnormal_surfactant_physiolog1.40347312
34MP0003890_abnormal_embryonic-extraembry1.36952514
35MP0001984_abnormal_olfaction1.36121938
36MP0009046_muscle_twitch1.33691503
37MP0003787_abnormal_imprinting1.31843804
38MP0003693_abnormal_embryo_hatching1.29642038
39MP0008007_abnormal_cellular_replicative1.29356432
40MP0010307_abnormal_tumor_latency1.29352702
41MP0005394_taste/olfaction_phenotype1.28161072
42MP0005499_abnormal_olfactory_system1.28161072
43MP0010094_abnormal_chromosome_stability1.26318220
44MP0002282_abnormal_trachea_morphology1.25701368
45MP0003111_abnormal_nucleus_morphology1.25254142
46MP0001672_abnormal_embryogenesis/_devel1.23580458
47MP0005380_embryogenesis_phenotype1.23580458
48MP0002796_impaired_skin_barrier1.21898973
49MP0000350_abnormal_cell_proliferation1.21344191
50MP0005551_abnormal_eye_electrophysiolog1.18979456
51MP0003121_genomic_imprinting1.18352566
52MP0005367_renal/urinary_system_phenotyp1.16785570
53MP0000516_abnormal_urinary_system1.16785570
54MP0001986_abnormal_taste_sensitivity1.16650128
55MP0001177_atelectasis1.14294981
56MP0002233_abnormal_nose_morphology1.13358726
57MP0002085_abnormal_embryonic_tissue1.09531418
58MP0002088_abnormal_embryonic_growth/wei1.08367027
59MP0002098_abnormal_vibrissa_morphology1.07369103
60MP0003984_embryonic_growth_retardation1.07083589
61MP0009703_decreased_birth_body1.06650750
62MP0004957_abnormal_blastocyst_morpholog1.06479916
63MP0005623_abnormal_meninges_morphology1.06261122
64MP0003937_abnormal_limbs/digits/tail_de1.04602457
65MP0001765_abnormal_ion_homeostasis1.03045045
66MP0003011_delayed_dark_adaptation1.02730485
67MP0001286_abnormal_eye_development0.97518644
68MP0001293_anophthalmia0.97371851
69MP0002234_abnormal_pharynx_morphology0.96538550
70MP0003755_abnormal_palate_morphology0.95534413
71MP0005379_endocrine/exocrine_gland_phen0.95288551
72MP0002086_abnormal_extraembryonic_tissu0.93786199
73MP0005501_abnormal_skin_physiology0.93235404
74MP0000358_abnormal_cell_content/0.92342062
75MP0001968_abnormal_touch/_nociception0.92330211
76MP0009672_abnormal_birth_weight0.92122632
77MP0004036_abnormal_muscle_relaxation0.91558130
78MP0005253_abnormal_eye_physiology0.88922812
79MP0001486_abnormal_startle_reflex0.88674712
80MP0004924_abnormal_behavior0.86432234
81MP0005386_behavior/neurological_phenoty0.86432234
82MP0001529_abnormal_vocalization0.86069331
83MP0006072_abnormal_retinal_apoptosis0.84868158
84MP0003943_abnormal_hepatobiliary_system0.84604880
85MP0001730_embryonic_growth_arrest0.79988666
86MP0005389_reproductive_system_phenotype0.79289311
87MP0003786_premature_aging0.79250563
88MP0003635_abnormal_synaptic_transmissio0.77843347
89MP0002751_abnormal_autonomic_nervous0.77802020
90MP0002736_abnormal_nociception_after0.77167767
91MP0003077_abnormal_cell_cycle0.76824317
92MP0002638_abnormal_pupillary_reflex0.74384908
93MP0001191_abnormal_skin_condition0.73819858
94MP0003183_abnormal_peptide_metabolism0.73473249
95MP0008057_abnormal_DNA_replication0.72739115
96MP0005266_abnormal_metabolism0.72511303
97MP0000377_abnormal_hair_follicle0.72345738
98MP0000579_abnormal_nail_morphology0.72046014
99MP0004808_abnormal_hematopoietic_stem0.71223203
100MP0002272_abnormal_nervous_system0.70992391
101MP0003861_abnormal_nervous_system0.70504014
102MP0004084_abnormal_cardiac_muscle0.70249266
103MP0005384_cellular_phenotype0.70159432
104MP0004859_abnormal_synaptic_plasticity0.69788733
105MP0000751_myopathy0.67854220
106MP0000631_abnormal_neuroendocrine_gland0.67841926
107MP0003935_abnormal_craniofacial_develop0.67680687
108MP0005397_hematopoietic_system_phenotyp0.67627858
109MP0001545_abnormal_hematopoietic_system0.67627858
110MP0002184_abnormal_innervation0.67061267
111MP0003115_abnormal_respiratory_system0.67015614
112MP0002909_abnormal_adrenal_gland0.66913154
113MP0004811_abnormal_neuron_physiology0.66523545
114MP0006036_abnormal_mitochondrial_physio0.66354705
115MP0008932_abnormal_embryonic_tissue0.66144755
116MP0002092_abnormal_eye_morphology0.66022875
117MP0002063_abnormal_learning/memory/cond0.62629244
118MP0003329_amyloid_beta_deposits0.62218162
119MP0005636_abnormal_mineral_homeostasis0.61716866
120MP0004145_abnormal_muscle_electrophysio0.61540358
121MP0009745_abnormal_behavioral_response0.57102136
122MP0006276_abnormal_autonomic_nervous0.57090196
123MP0002572_abnormal_emotion/affect_behav0.56699632
124MP0006035_abnormal_mitochondrial_morpho0.56510245
125MP0004270_analgesia0.55449305
126MP0002102_abnormal_ear_morphology0.54677982
127MP0008995_early_reproductive_senescence0.53116893
128MP0005503_abnormal_tendon_morphology0.51606180
129MP0005391_vision/eye_phenotype0.49957000
130MP0002089_abnormal_postnatal_growth/wei0.49006860
131MP0001764_abnormal_homeostasis0.48981104
132MP0001697_abnormal_embryo_size0.47743996
133MP0005646_abnormal_pituitary_gland0.46128216
134MP0003123_paternal_imprinting0.45920450
135MP0002064_seizures0.44805277
136MP0004134_abnormal_chest_morphology0.44003853
137MP0001188_hyperpigmentation0.43544756
138MP0002269_muscular_atrophy0.41810707
139MP0003879_abnormal_hair_cell0.41579035
140MP0008569_lethality_at_weaning0.40903895
141MP0002080_prenatal_lethality0.39815865
142MP0003699_abnormal_female_reproductive0.39770703
143MP0000534_abnormal_ureter_morphology0.38656513
144MP0000013_abnormal_adipose_tissue0.38607916
145MP0002822_catalepsy0.38569714
146MP0005647_abnormal_sex_gland0.38186603
147MP0002169_no_abnormal_phenotype0.37672166
148MP0002873_normal_phenotype0.37624204
149MP0000313_abnormal_cell_death0.37021068
150MP0002067_abnormal_sensory_capabilities0.36816767
151MP0001727_abnormal_embryo_implantation0.35715556
152MP0002152_abnormal_brain_morphology0.35324570
153MP0002084_abnormal_developmental_patter0.35204359
154MP0001661_extended_life_span0.34574782
155MP0009780_abnormal_chondrocyte_physiolo0.34181144
156MP0002132_abnormal_respiratory_system0.33564412
157MP0002734_abnormal_mechanical_nocicepti0.33255029
158MP0001905_abnormal_dopamine_level0.32836137
159MP0005195_abnormal_posterior_eye0.31487886

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)8.80339601
2Abnormal respiratory motile cilium morphology (HP:0005938)8.80339601
3Abnormal respiratory motile cilium physiology (HP:0012261)8.58992502
4Rhinitis (HP:0012384)7.55959301
5Chronic bronchitis (HP:0004469)7.19753841
6Abnormal ciliary motility (HP:0012262)6.73353349
7Infertility (HP:0000789)6.37349131
8Nasal polyposis (HP:0100582)5.65917287
9Abnormality of the nasal mucosa (HP:0000433)4.75117269
10Bronchitis (HP:0012387)4.55047113
11Bronchiectasis (HP:0002110)4.22068900
12Nephronophthisis (HP:0000090)3.93333856
13Male infertility (HP:0003251)3.82224320
14Medulloblastoma (HP:0002885)3.68747154
15Abnormal spermatogenesis (HP:0008669)3.50901069
16Papillary thyroid carcinoma (HP:0002895)3.43913064
17Recurrent otitis media (HP:0000403)3.33991899
18Volvulus (HP:0002580)3.18826835
19Hypoglycemic seizures (HP:0002173)3.09589505
20Abnormality of the labia minora (HP:0012880)2.98849036
21Glioma (HP:0009733)2.96520883
22Recurrent sinusitis (HP:0011108)2.89130630
23Thyroid carcinoma (HP:0002890)2.83048343
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.82983362
25Gonadotropin excess (HP:0000837)2.79394331
26Recurrent bronchitis (HP:0002837)2.78575962
27Abnormality of the renal medulla (HP:0100957)2.77795662
28Abnormality of chromosome stability (HP:0003220)2.76606445
29Medial flaring of the eyebrow (HP:0010747)2.74667033
30Hyperinsulinemic hypoglycemia (HP:0000825)2.73233567
31Chromsome breakage (HP:0040012)2.69763968
32Rhabdomyosarcoma (HP:0002859)2.69689876
33Insidious onset (HP:0003587)2.63113306
34Termporal pattern (HP:0011008)2.63113306
35Ependymoma (HP:0002888)2.59921671
36Hypoplasia of the capital femoral epiphysis (HP:0003090)2.54523974
37Meckel diverticulum (HP:0002245)2.52415937
38Abnormality of midbrain morphology (HP:0002418)2.50815187
39Molar tooth sign on MRI (HP:0002419)2.50815187
40Impulsivity (HP:0100710)2.50704707
41Abnormality of the astrocytes (HP:0100707)2.46473250
42Astrocytoma (HP:0009592)2.46473250
43Cerebellar dysplasia (HP:0007033)2.45867779
44Abnormality of the ileum (HP:0001549)2.44403145
45Hypoglycemic coma (HP:0001325)2.44002501
46Curly hair (HP:0002212)2.43285938
47Resting tremor (HP:0002322)2.40065585
48Breast carcinoma (HP:0003002)2.39342266
49Sensory axonal neuropathy (HP:0003390)2.36260995
50Neoplasm of the oral cavity (HP:0100649)2.30363926
51Abnormal hair whorl (HP:0010721)2.29978275
52Unilateral renal agenesis (HP:0000122)2.29560049
53Abnormality of the preputium (HP:0100587)2.28655095
54Tubulointerstitial nephritis (HP:0001970)2.25990397
55Hyperventilation (HP:0002883)2.24703325
56Absent epiphyses (HP:0010577)2.22466774
57Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.22466774
58Amyotrophic lateral sclerosis (HP:0007354)2.16673894
59Azoospermia (HP:0000027)2.11989413
60Congenital stationary night blindness (HP:0007642)2.11483602
61Facial hemangioma (HP:0000329)2.11334187
62Intestinal atresia (HP:0011100)2.10451917
63Neoplasm of the adrenal cortex (HP:0100641)2.09132041
64Cholecystitis (HP:0001082)2.05947579
65Abnormal gallbladder physiology (HP:0012438)2.05947579
66Aplasia/Hypoplasia of the uvula (HP:0010293)2.04397068
67Postnatal microcephaly (HP:0005484)2.03391312
68Neoplasm of striated muscle (HP:0009728)2.02047563
69Nephroblastoma (Wilms tumor) (HP:0002667)2.01842918
70Dynein arm defect of respiratory motile cilia (HP:0012255)12.3332717
71Absent/shortened dynein arms (HP:0200106)12.3332717
72Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.1347303
73Symptomatic seizures (HP:0011145)1.99556406
74Abnormality of methionine metabolism (HP:0010901)1.97707691
75Embryonal renal neoplasm (HP:0011794)1.93485395
76Cone-rod dystrophy (HP:0000548)1.92506086
77Septate vagina (HP:0001153)1.92467924
78Fibular hypoplasia (HP:0003038)1.92271862
79Median cleft lip (HP:0000161)1.90925650
80Abnormality of the lower motor neuron (HP:0002366)1.89541634
81Bundle branch block (HP:0011710)1.88967764
82Cortical dysplasia (HP:0002539)1.88653478
83Tubular atrophy (HP:0000092)1.88247301
84Neoplasm of the thyroid gland (HP:0100031)1.87563188
85Genital tract atresia (HP:0001827)1.87392457
86Abnormality of macular pigmentation (HP:0008002)1.87022680
87Small intestinal stenosis (HP:0012848)1.85097999
88Duodenal stenosis (HP:0100867)1.85097999
89Type II lissencephaly (HP:0007260)1.84498749
90Choroideremia (HP:0001139)1.81935630
91Short ribs (HP:0000773)1.81842161
92Drooling (HP:0002307)1.81035643
93Congenital primary aphakia (HP:0007707)1.81000768
94Colon cancer (HP:0003003)1.79183378
95Short femoral neck (HP:0100864)1.78937421
96Dyschromatopsia (HP:0007641)1.78706442
97Gait imbalance (HP:0002141)1.78547477
98Vaginal atresia (HP:0000148)1.77919886
99Pancreatic islet-cell hyperplasia (HP:0004510)1.77340763
100Optic nerve hypoplasia (HP:0000609)1.77187548
101Abnormality of the fetal cardiovascular system (HP:0010948)1.77113090
102Abnormal umbilical cord blood vessels (HP:0011403)1.77113090
103Single umbilical artery (HP:0001195)1.77113090
104Insulin-resistant diabetes mellitus (HP:0000831)1.75567227
105Clitoromegaly (HP:0000057)1.75212838
106Growth hormone deficiency (HP:0000824)1.74836635
107Attenuation of retinal blood vessels (HP:0007843)1.73191760
108Tubulointerstitial abnormality (HP:0001969)1.72606545
109Abnormality of the septum pellucidum (HP:0007375)1.72601074
110Abnormality of the metopic suture (HP:0005556)1.71861447
111Meningioma (HP:0002858)1.71597866
112Decreased central vision (HP:0007663)1.69435996
113Neoplasm of the adrenal gland (HP:0100631)1.69085570
114Sloping forehead (HP:0000340)1.66526909
115Failure to thrive in infancy (HP:0001531)1.65973123
116Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.65405774
117Abnormal lung lobation (HP:0002101)1.64417264
118Overlapping toe (HP:0001845)1.64378623
119Nephrogenic diabetes insipidus (HP:0009806)1.64046679
120Spastic tetraparesis (HP:0001285)1.63505532
121Renal cortical cysts (HP:0000803)1.62799675
122Acute myeloid leukemia (HP:0004808)1.62481993
123Oculomotor apraxia (HP:0000657)1.61928814
124Bony spicule pigmentary retinopathy (HP:0007737)1.61864783
125Large earlobe (HP:0009748)1.61851849
126Progressive hearing impairment (HP:0001730)1.61574040
127Birth length less than 3rd percentile (HP:0003561)1.60918483
128Biliary tract neoplasm (HP:0100574)1.60700608
129Abnormality of dentin (HP:0010299)1.60403408
130Progressive inability to walk (HP:0002505)1.60350815
131Abnormality of the musculature of the pelvis (HP:0001469)1.60136035
132Abnormality of the hip-girdle musculature (HP:0001445)1.60136035
133Long foot (HP:0001833)1.59881428
134Dyskinesia (HP:0100660)1.59650802
135Pili torti (HP:0003777)1.59333079
136Microglossia (HP:0000171)1.58745334
137Deep philtrum (HP:0002002)1.58646386
138Upper limb muscle weakness (HP:0003484)1.57582259
139Aplasia/Hypoplasia of the lens (HP:0008063)1.57575903
140Tetraparesis (HP:0002273)1.57371604
141Microvesicular hepatic steatosis (HP:0001414)1.57325540
142Glucose intolerance (HP:0000833)1.57246727
143Astigmatism (HP:0000483)1.57069736
144Facial cleft (HP:0002006)1.56363078
145Abnormality of permanent molar morphology (HP:0011071)1.56314846
146Abnormality of the dental root (HP:0006486)1.56314846
147Taurodontia (HP:0000679)1.56314846
148Abnormality of the duodenum (HP:0002246)1.56311339
149Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.56207630
150Abnormality of aspartate family amino acid metabolism (HP:0010899)1.55752191
151Excessive salivation (HP:0003781)1.55718314
152Agnosia (HP:0010524)1.54463623
153Pancreatic cysts (HP:0001737)1.53957338
154Specific learning disability (HP:0001328)1.53922713
155Abnormality of the anterior horn cell (HP:0006802)1.53885619
156Degeneration of anterior horn cells (HP:0002398)1.53885619
157Decreased electroretinogram (ERG) amplitude (HP:0000654)1.51400132
158Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.51180082
159J-shaped sella turcica (HP:0002680)1.50917465
160Postaxial foot polydactyly (HP:0001830)1.50503960
161Heterotopia (HP:0002282)1.48810367
162Delusions (HP:0000746)1.45626843
163Impaired proprioception (HP:0010831)1.44730979
164Postaxial hand polydactyly (HP:0001162)1.44690487
165Type 2 muscle fiber atrophy (HP:0003554)1.43386980
166Abnormality of molar (HP:0011077)1.43026326
167Abnormality of molar morphology (HP:0011070)1.43026326
168Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.42856687
169Chronic sinusitis (HP:0011109)1.41227145
170Lissencephaly (HP:0001339)1.39972363
171Abnormality of ocular smooth pursuit (HP:0000617)1.38202857
172Abnormality of the dental pulp (HP:0006479)1.37190808
173Retinal dysplasia (HP:0007973)1.35546072
174Type II diabetes mellitus (HP:0005978)1.34933517
175Short nail (HP:0001799)1.33893394
176Stage 5 chronic kidney disease (HP:0003774)1.33413163
177Poor coordination (HP:0002370)1.30759378
178Congenital hepatic fibrosis (HP:0002612)1.29367900
179Delayed gross motor development (HP:0002194)1.28696146
180Pendular nystagmus (HP:0012043)1.27735022
181Congenital malformation of the right heart (HP:0011723)1.26961802
182Double outlet right ventricle (HP:0001719)1.26961802
183Broad distal phalanx of finger (HP:0009836)1.26632199
184Difficulty climbing stairs (HP:0003551)1.26290516
185Renal dysplasia (HP:0000110)1.26128972
186Anterior segment dysgenesis (HP:0007700)1.26119489
187Pancreatic fibrosis (HP:0100732)1.26042119
188Hemiparesis (HP:0001269)1.25576485
189Muscle fiber atrophy (HP:0100295)1.23320834
190Irregular epiphyses (HP:0010582)1.22976837
191Absent rod-and cone-mediated responses on ERG (HP:0007688)1.21635442
192Inability to walk (HP:0002540)1.21628052

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.97266467
2PDK47.97266467
3TESK15.56136802
4PDK25.01364803
5PRKD34.51950467
6ICK3.13674210
7TRIM283.11032396
8SRPK13.00336669
9MKNK22.41696650
10BUB12.39812785
11MST42.36321467
12ERBB32.25782900
13BCR2.21687745
14NEK22.16001638
15PTK2B2.12682450
16MKNK12.06904570
17CCNB12.05276329
18MAP4K22.05104057
19NUAK11.95963115
20PNCK1.93151628
21BRD41.89659013
22PBK1.80134209
23WEE11.78136377
24SCYL21.68257917
25WNK41.62939483
26PLK21.54084196
27ERBB41.50036852
28STK381.47056135
29WNK31.43881755
30DYRK31.42577627
31ZAK1.28094001
32LATS11.27342604
33TNIK1.12899533
34FRK1.12548109
35TAF11.12471402
36STK391.12043133
37BRSK21.11764153
38DYRK1B1.05554859
39CSNK1G11.04724268
40TIE11.03628571
41YES11.00238959
42PDK10.99605418
43EIF2AK20.98920646
44CSNK1G30.95658864
45CSNK1G20.95489292
46STK160.93164756
47INSRR0.91196911
48TESK20.90715479
49PASK0.89989683
50EPHA30.89359935
51RIPK40.83186588
52PIK3CG0.81985860
53CDK60.78194499
54IRAK10.70862939
55BRSK10.70029743
56CSNK1A1L0.67273663
57CDK70.65743419
58MAPK130.65427098
59ALK0.64335718
60FER0.63936100
61BRAF0.62622451
62CAMK1G0.61031283
63TTK0.60212431
64PRKCG0.58902846
65CDC70.57307671
66PAK30.56959822
67MAPK150.55737586
68PDPK10.55104006
69CHEK10.54605271
70ACVR1B0.54107898
71CHEK20.53442526
72MAP3K120.53154196
73STK240.52736171
74CDK10.52042591
75PLK10.52018754
76MUSK0.51432735
77PLK40.50909003
78CSNK1E0.50806756
79MAPKAPK50.49443416
80CSNK1D0.49382781
81CDK90.48510674
82PAK10.47476748
83CDK20.47375051
84CAMKK10.46298449
85PRKCE0.45619477
86TEC0.44257329
87EIF2AK10.42917420
88MAP2K70.42822902
89UHMK10.42765118
90KSR10.42363601
91STK38L0.41641484
92CAMKK20.40924741
93MAP3K40.40569639
94EPHA40.40238887
95PINK10.38475926
96NME10.38348603
97STK30.38347186
98ARAF0.38101812
99MINK10.35729817
100DAPK10.35373278
101TYRO30.34510569
102BMPR1B0.33653708
103GSK3B0.33642898
104MAP2K60.32804857
105ATR0.32713747
106WNK10.32301042
107LATS20.31984396
108SIK30.31949640
109PRKDC0.31261375
110ZAP700.30971592
111CDK30.30502060
112NTRK30.29894793
113IRAK20.29891547
114MARK10.29659730
115TSSK60.29516829
116MAPK100.29216308
117EGFR0.29113750
118MAP3K100.29097411
119AURKA0.29050388
120PRKCZ0.29017761
121CDK150.28989172
122CDK11A0.28769684
123CDK180.28634414
124MAPK140.27691561
125TGFBR10.26394913
126NTRK20.26311638
127MAPK90.25875553
128CDK140.25663682
129PLK30.25597905
130EPHA20.25361459
131AKT30.25289311
132TAOK10.24611322
133PAK40.24554545
134RPS6KA40.23900180
135NEK60.22809711
136CDK80.22628452
137CDK190.21601702
138VRK10.21293816
139ATM0.20768335
140GRK50.18673448
141CSNK2A20.18141912
142CSNK2A10.17892396
143MAP3K50.17749396
144EIF2AK30.17497094
145PAK20.16518808
146PIM20.16199915
147MARK30.16181474
148KDR0.15543059
149NME20.14792908
150CASK0.14749319
151CDK40.14069898
152NEK10.12424740
153CAMK2A0.11173347
154RPS6KB10.10407240
155MAP3K60.09217382
156MAP2K40.08728140
157AURKB0.08557537

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.18408069
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.43830642
3Non-homologous end-joining_Homo sapiens_hsa034503.31092292
4Basal transcription factors_Homo sapiens_hsa030222.98299998
5Phototransduction_Homo sapiens_hsa047442.82034547
6Pyruvate metabolism_Homo sapiens_hsa006202.77459538
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.56947196
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.54148446
9Oocyte meiosis_Homo sapiens_hsa041142.43171915
10RNA transport_Homo sapiens_hsa030132.26857035
11Amphetamine addiction_Homo sapiens_hsa050312.14313039
12Glucagon signaling pathway_Homo sapiens_hsa049222.14213567
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.05660274
14Proteasome_Homo sapiens_hsa030502.01390311
15Huntingtons disease_Homo sapiens_hsa050161.92255909
16Pentose phosphate pathway_Homo sapiens_hsa000301.91985338
17Fatty acid biosynthesis_Homo sapiens_hsa000611.87535842
18Circadian rhythm_Homo sapiens_hsa047101.74662752
19Carbohydrate digestion and absorption_Homo sapiens_hsa049731.72359753
20Purine metabolism_Homo sapiens_hsa002301.68173190
21Fanconi anemia pathway_Homo sapiens_hsa034601.67745182
22Cardiac muscle contraction_Homo sapiens_hsa042601.64545386
23mRNA surveillance pathway_Homo sapiens_hsa030151.57789727
24Fructose and mannose metabolism_Homo sapiens_hsa000511.57573341
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55870122
26Long-term potentiation_Homo sapiens_hsa047201.52707741
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.51692465
28Synaptic vesicle cycle_Homo sapiens_hsa047211.51006270
29Linoleic acid metabolism_Homo sapiens_hsa005911.48044047
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47515014
31p53 signaling pathway_Homo sapiens_hsa041151.47311000
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.47246330
33Selenocompound metabolism_Homo sapiens_hsa004501.44086111
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34365461
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.34200179
36Pyrimidine metabolism_Homo sapiens_hsa002401.34030665
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31440782
38DNA replication_Homo sapiens_hsa030301.31075338
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30605843
40Propanoate metabolism_Homo sapiens_hsa006401.27743777
41Spliceosome_Homo sapiens_hsa030401.27022636
42Renin secretion_Homo sapiens_hsa049241.18183918
43Glycerophospholipid metabolism_Homo sapiens_hsa005641.15507829
44Carbon metabolism_Homo sapiens_hsa012001.15170814
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14230621
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12489925
47Collecting duct acid secretion_Homo sapiens_hsa049661.11192671
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08384989
49One carbon pool by folate_Homo sapiens_hsa006701.06892469
50Biosynthesis of amino acids_Homo sapiens_hsa012301.06271784
51Butanoate metabolism_Homo sapiens_hsa006501.05988836
52RNA degradation_Homo sapiens_hsa030181.02766048
53Glycerolipid metabolism_Homo sapiens_hsa005611.02105567
54Steroid biosynthesis_Homo sapiens_hsa001001.00049644
55Insulin secretion_Homo sapiens_hsa049110.97543517
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97395868
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.96976005
58Cell cycle_Homo sapiens_hsa041100.96500555
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94735351
60RNA polymerase_Homo sapiens_hsa030200.94148420
61Nucleotide excision repair_Homo sapiens_hsa034200.92556016
62Olfactory transduction_Homo sapiens_hsa047400.91171703
63Oxidative phosphorylation_Homo sapiens_hsa001900.90800700
64N-Glycan biosynthesis_Homo sapiens_hsa005100.90103359
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89762533
66Dorso-ventral axis formation_Homo sapiens_hsa043200.87663157
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86896677
68Antigen processing and presentation_Homo sapiens_hsa046120.85788739
69Estrogen signaling pathway_Homo sapiens_hsa049150.85289182
70Circadian entrainment_Homo sapiens_hsa047130.85056955
71Parkinsons disease_Homo sapiens_hsa050120.84973794
72Dopaminergic synapse_Homo sapiens_hsa047280.83900031
73TGF-beta signaling pathway_Homo sapiens_hsa043500.83797060
74Fatty acid elongation_Homo sapiens_hsa000620.83545340
75Mismatch repair_Homo sapiens_hsa034300.82766126
76Regulation of autophagy_Homo sapiens_hsa041400.82501125
77Nicotine addiction_Homo sapiens_hsa050330.81703694
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80034249
79Base excision repair_Homo sapiens_hsa034100.79597488
80Homologous recombination_Homo sapiens_hsa034400.79455469
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79175387
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78103256
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75598406
84MicroRNAs in cancer_Homo sapiens_hsa052060.74753453
85Taste transduction_Homo sapiens_hsa047420.74443434
86Calcium signaling pathway_Homo sapiens_hsa040200.73267715
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71803194
88Hippo signaling pathway_Homo sapiens_hsa043900.71446634
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70876145
90beta-Alanine metabolism_Homo sapiens_hsa004100.69254071
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69042492
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66867551
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61099651
94Cocaine addiction_Homo sapiens_hsa050300.60698892
95Alzheimers disease_Homo sapiens_hsa050100.60534563
96Folate biosynthesis_Homo sapiens_hsa007900.59283871
97Adherens junction_Homo sapiens_hsa045200.59105805
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58040196
99Salivary secretion_Homo sapiens_hsa049700.57847783
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55391239
101Hedgehog signaling pathway_Homo sapiens_hsa043400.54727029
102Lysine degradation_Homo sapiens_hsa003100.54313955
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.53692900
104Thyroid hormone synthesis_Homo sapiens_hsa049180.53266715
105Glutathione metabolism_Homo sapiens_hsa004800.51814531
106Protein export_Homo sapiens_hsa030600.51288401
107Fatty acid metabolism_Homo sapiens_hsa012120.50619350
108Colorectal cancer_Homo sapiens_hsa052100.49731146
109Alcoholism_Homo sapiens_hsa050340.48795115
110Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48654876
111VEGF signaling pathway_Homo sapiens_hsa043700.47834957
112Tight junction_Homo sapiens_hsa045300.47722043
113Prostate cancer_Homo sapiens_hsa052150.47276335
114Inositol phosphate metabolism_Homo sapiens_hsa005620.46651597
115Epstein-Barr virus infection_Homo sapiens_hsa051690.45333366
116Nitrogen metabolism_Homo sapiens_hsa009100.44654828
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44500476
118Glutamatergic synapse_Homo sapiens_hsa047240.43790361
119cAMP signaling pathway_Homo sapiens_hsa040240.42660839
120Oxytocin signaling pathway_Homo sapiens_hsa049210.42303953
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41728421
122Wnt signaling pathway_Homo sapiens_hsa043100.41662632
123Renal cell carcinoma_Homo sapiens_hsa052110.41571005
124Thyroid cancer_Homo sapiens_hsa052160.40687979
125Endocytosis_Homo sapiens_hsa041440.40582063
126Viral carcinogenesis_Homo sapiens_hsa052030.38699914
127Gastric acid secretion_Homo sapiens_hsa049710.37664537
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.37441060
129Metabolic pathways_Homo sapiens_hsa011000.36818092
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36747748
131Sphingolipid metabolism_Homo sapiens_hsa006000.36556328
132Mineral absorption_Homo sapiens_hsa049780.34789893
133AMPK signaling pathway_Homo sapiens_hsa041520.34608596
134Sulfur metabolism_Homo sapiens_hsa009200.33920603
135Legionellosis_Homo sapiens_hsa051340.32185915
136Vibrio cholerae infection_Homo sapiens_hsa051100.31484840
137PPAR signaling pathway_Homo sapiens_hsa033200.30791873
138Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30216641
139Morphine addiction_Homo sapiens_hsa050320.28924959
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28622233
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27521263
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22746510
143Serotonergic synapse_Homo sapiens_hsa047260.21866139
144Long-term depression_Homo sapiens_hsa047300.20497971
145Endometrial cancer_Homo sapiens_hsa052130.20401836
146Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.20235234
147HIF-1 signaling pathway_Homo sapiens_hsa040660.18208465
148Peroxisome_Homo sapiens_hsa041460.17635341
149Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.16921952
150Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16077433

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