BAG4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.57968138
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.81043897
3negative regulation of DNA-dependent DNA replication (GO:2000104)4.69831836
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.25160994
5chromatin remodeling at centromere (GO:0031055)4.24366671
6histone exchange (GO:0043486)4.10428052
7proteasome assembly (GO:0043248)4.09349178
8CENP-A containing nucleosome assembly (GO:0034080)4.06339519
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.04313507
10replication fork processing (GO:0031297)4.02233431
11glutamate secretion (GO:0014047)3.99430194
12lactate metabolic process (GO:0006089)3.97683379
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.95943252
14vocalization behavior (GO:0071625)3.91447724
15DNA replication checkpoint (GO:0000076)3.79383440
16somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.76716298
17isotype switching (GO:0045190)3.76716298
18somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.76716298
19regulation of glutamate receptor signaling pathway (GO:1900449)3.76366407
20water-soluble vitamin biosynthetic process (GO:0042364)3.64712492
21synapsis (GO:0007129)3.64436963
22neurotransmitter secretion (GO:0007269)3.60592402
23regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.59624843
24regulation of mitotic spindle checkpoint (GO:1903504)3.59624843
25RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.58220802
26regulation of nuclear cell cycle DNA replication (GO:0033262)3.57266219
27synaptic vesicle maturation (GO:0016188)3.56057921
28DNA catabolic process, exonucleolytic (GO:0000738)3.54314064
29synaptic vesicle exocytosis (GO:0016079)3.54023295
30negative regulation of DNA recombination (GO:0045910)3.46629480
31regulation of helicase activity (GO:0051095)3.46207948
32ionotropic glutamate receptor signaling pathway (GO:0035235)3.45999541
33somatic diversification of immune receptors via somatic mutation (GO:0002566)3.45189590
34somatic hypermutation of immunoglobulin genes (GO:0016446)3.45189590
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.44903648
36telomere maintenance via telomerase (GO:0007004)3.42915723
37cullin deneddylation (GO:0010388)3.40631273
38locomotory exploration behavior (GO:0035641)3.38177576
39positive regulation of synapse maturation (GO:0090129)3.38032943
40spindle checkpoint (GO:0031577)3.37847727
41protein localization to synapse (GO:0035418)3.36736139
42metaphase plate congression (GO:0051310)3.34413859
43respiratory chain complex IV assembly (GO:0008535)3.33428634
44non-recombinational repair (GO:0000726)3.31635326
45double-strand break repair via nonhomologous end joining (GO:0006303)3.31635326
46mitotic spindle checkpoint (GO:0071174)3.31364486
47response to X-ray (GO:0010165)3.30215406
48neuron-neuron synaptic transmission (GO:0007270)3.28572298
49positive regulation of protein autophosphorylation (GO:0031954)3.26214533
50protein K6-linked ubiquitination (GO:0085020)3.26198650
51neurotransmitter-gated ion channel clustering (GO:0072578)3.24604588
52synaptic vesicle docking involved in exocytosis (GO:0016081)3.23961162
53glutamate receptor signaling pathway (GO:0007215)3.23069338
54regulation of synaptic vesicle exocytosis (GO:2000300)3.23069270
55maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.22987152
56regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.18545327
57glycine transport (GO:0015816)3.16835225
58regulation of long-term neuronal synaptic plasticity (GO:0048169)3.14669618
59synaptic transmission, glutamatergic (GO:0035249)3.14323104
60regulation of synaptic vesicle transport (GO:1902803)3.13102255
61exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.13038463
62mitotic metaphase plate congression (GO:0007080)3.12724198
63dicarboxylic acid biosynthetic process (GO:0043650)3.11960668
64regulation of neuronal synaptic plasticity (GO:0048168)3.11896629
65ribosome assembly (GO:0042255)3.11752754
66neuron cell-cell adhesion (GO:0007158)3.08348968
67negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.08219385
68regulation of DNA endoreduplication (GO:0032875)3.07606550
69protein deneddylation (GO:0000338)3.07253911
70regulation of centriole replication (GO:0046599)3.07191396
71gamma-aminobutyric acid transport (GO:0015812)3.05227684
72DNA ligation (GO:0006266)3.04958079
73response to pheromone (GO:0019236)3.03833145
74negative regulation of sodium ion transport (GO:0010766)3.03462950
75nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.02858885
76mitotic sister chromatid cohesion (GO:0007064)3.02211286
77homocysteine metabolic process (GO:0050667)3.02097904
78DNA replication-independent nucleosome assembly (GO:0006336)3.01973316
79DNA replication-independent nucleosome organization (GO:0034724)3.01973316
80positive regulation of dendritic spine morphogenesis (GO:0061003)3.00742939
81layer formation in cerebral cortex (GO:0021819)2.99223415
82urea cycle (GO:0000050)2.98892063
83urea metabolic process (GO:0019627)2.98892063
84double-strand break repair via homologous recombination (GO:0000724)2.98793235
85negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.98555434
86negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.98555434
87negative regulation of mitotic sister chromatid segregation (GO:0033048)2.98555434
88negative regulation of mitotic sister chromatid separation (GO:2000816)2.98555434
89negative regulation of sister chromatid segregation (GO:0033046)2.98555434
90recombinational repair (GO:0000725)2.97962857
91response to histamine (GO:0034776)2.97919346
92anterior/posterior axis specification, embryo (GO:0008595)2.96574557
93positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.95449444
94neurotransmitter transport (GO:0006836)2.94711763
95purine nucleobase biosynthetic process (GO:0009113)2.94407738
96drug catabolic process (GO:0042737)2.94059080
97erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.93984621
98L-phenylalanine catabolic process (GO:0006559)2.93984621
99IMP biosynthetic process (GO:0006188)2.92470347
100proline transport (GO:0015824)2.91999239
101keratinocyte development (GO:0003334)2.91317956
102somatic recombination of immunoglobulin gene segments (GO:0016447)2.91171649
103L-phenylalanine metabolic process (GO:0006558)2.89125767
104erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.89125767
105negative regulation of chromosome segregation (GO:0051985)2.88906451
106regulation of synapse maturation (GO:0090128)2.87950546
107regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.87932570
108regulation of mitotic metaphase/anaphase transition (GO:0030071)2.87932570
109female gonad development (GO:0008585)2.87792978
110histone H2A acetylation (GO:0043968)2.87711247
111protein neddylation (GO:0045116)2.86741903
112detection of calcium ion (GO:0005513)2.85757155
113regulation of glutamate secretion (GO:0014048)2.85242171
114anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.83708076
115long-term memory (GO:0007616)2.83066652
116kinetochore organization (GO:0051383)2.82109817
117maturation of 5.8S rRNA (GO:0000460)2.81652663
118glutamate metabolic process (GO:0006536)2.81116118
119serine family amino acid catabolic process (GO:0009071)2.80705061
120regulation of clathrin-mediated endocytosis (GO:2000369)2.80163598
121kinetochore assembly (GO:0051382)2.80142223
122regulation of sister chromatid segregation (GO:0033045)2.79540730
123regulation of mitotic sister chromatid separation (GO:0010965)2.79540730
124regulation of mitotic sister chromatid segregation (GO:0033047)2.79540730
125establishment of integrated proviral latency (GO:0075713)2.79307499
126behavioral defense response (GO:0002209)2.78926936
127behavioral fear response (GO:0001662)2.78926936
128folic acid-containing compound biosynthetic process (GO:0009396)2.78624941
129somatic diversification of immunoglobulins (GO:0016445)2.77165983
130regulation of neurotransmitter levels (GO:0001505)2.75782666
131exploration behavior (GO:0035640)2.75291468
132response to parathyroid hormone (GO:0071107)2.75264170
133lysine catabolic process (GO:0006554)2.74054544
134lysine metabolic process (GO:0006553)2.74054544
135G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.73935209
136cytochrome complex assembly (GO:0017004)2.73802224
137neuronal action potential propagation (GO:0019227)2.73419500
138histone mRNA metabolic process (GO:0008334)2.73394913
139negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.72462386
140negative regulation of ligase activity (GO:0051352)2.72462386
141glycine metabolic process (GO:0006544)2.71260729
142behavioral response to cocaine (GO:0048148)2.70765576
143positive regulation of neurotransmitter secretion (GO:0001956)2.70521268
144attachment of spindle microtubules to kinetochore (GO:0008608)2.70292869
145regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.69845018
146aromatic amino acid family catabolic process (GO:0009074)2.69408390
147mitotic spindle assembly checkpoint (GO:0007094)2.69046235
148DNA strand renaturation (GO:0000733)2.68767362
149regulation of dendritic spine morphogenesis (GO:0061001)2.68422046
150RNA-dependent DNA replication (GO:0006278)2.67224283
151DNA deamination (GO:0045006)2.66203071
152spindle assembly checkpoint (GO:0071173)2.65629406
153postreplication repair (GO:0006301)2.65297073
154resolution of meiotic recombination intermediates (GO:0000712)2.65175720
155signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.64497773
156signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.64497773
157signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.64497773
158branched-chain amino acid catabolic process (GO:0009083)2.64365030
159intraspecies interaction between organisms (GO:0051703)2.63496630
160social behavior (GO:0035176)2.63496630
161regulation of cellular amino acid metabolic process (GO:0006521)2.62905795
162regulation of chromosome segregation (GO:0051983)2.62622562
163DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.62516933
164positive regulation of membrane potential (GO:0045838)2.61968683
165regulation of synaptic plasticity (GO:0048167)2.61840276
166regulation of translational termination (GO:0006449)2.57906239
167cysteine metabolic process (GO:0006534)2.57551882
168negative regulation of hormone biosynthetic process (GO:0032353)2.56920862
169negative regulation of hormone metabolic process (GO:0032351)2.56920862
170nitrogen cycle metabolic process (GO:0071941)2.56874187
171regulation of excitatory postsynaptic membrane potential (GO:0060079)2.56720303
172pre-miRNA processing (GO:0031054)2.56516052
173chemosensory behavior (GO:0007635)2.54226187
174negative regulation of synaptic transmission, GABAergic (GO:0032229)2.51968578
175fear response (GO:0042596)2.51118182
176vesicle transport along microtubule (GO:0047496)2.50859100
177gamma-aminobutyric acid signaling pathway (GO:0007214)2.50499466
178piRNA metabolic process (GO:0034587)2.50359823
179exogenous drug catabolic process (GO:0042738)2.49151325
180DNA replication-dependent nucleosome assembly (GO:0006335)2.48602194
181DNA replication-dependent nucleosome organization (GO:0034723)2.48602194
182positive regulation of neurotransmitter transport (GO:0051590)2.48580227
183kynurenine metabolic process (GO:0070189)2.46864348
184regulation of cAMP-dependent protein kinase activity (GO:2000479)2.46780266
185regulation of female receptivity (GO:0045924)2.46114043
186long-term synaptic potentiation (GO:0060291)2.45861776
187regulation of sodium ion transmembrane transporter activity (GO:2000649)2.44447976
188regulation of postsynaptic membrane potential (GO:0060078)2.43354310
189pyrimidine nucleobase catabolic process (GO:0006208)2.41006434
190one-carbon metabolic process (GO:0006730)2.40606766
191regulation of meiosis I (GO:0060631)2.40073145
192neuromuscular process controlling posture (GO:0050884)2.39920782
193regulation of synaptic transmission, glutamatergic (GO:0051966)2.39645543
194negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.39182246
195startle response (GO:0001964)2.39131709
196regulation of calcium ion-dependent exocytosis (GO:0017158)2.39122464
197alpha-amino acid catabolic process (GO:1901606)2.37361493

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.63977889
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.67236963
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.66154251
4E2F7_22180533_ChIP-Seq_HELA_Human3.47248225
5GBX2_23144817_ChIP-Seq_PC3_Human2.92738798
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.83806983
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.80227909
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.48357921
9REST_21632747_ChIP-Seq_MESCs_Mouse2.44366770
10ELK1_19687146_ChIP-ChIP_HELA_Human2.43795735
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.30372660
12TAF15_26573619_Chip-Seq_HEK293_Human2.23946412
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.17579760
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.17065032
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.14564135
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13295070
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.13004155
18SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.10289410
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09534876
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.99314286
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97932409
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97391795
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97371363
24POU5F1_16153702_ChIP-ChIP_HESCs_Human1.96957984
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.95316266
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85312066
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.73272382
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71811991
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.71113456
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.68949944
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.67751645
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66905620
33FUS_26573619_Chip-Seq_HEK293_Human1.66465162
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.66440469
35* VDR_23849224_ChIP-Seq_CD4+_Human1.64482993
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63055165
37RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.60851591
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.58969247
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.58274000
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.57216712
41* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.57046495
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52911997
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.48797514
44NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.47514857
45IGF1R_20145208_ChIP-Seq_DFB_Human1.46744378
46MYC_18940864_ChIP-ChIP_HL60_Human1.46425401
47FOXP3_21729870_ChIP-Seq_TREG_Human1.46127493
48ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.45769835
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45520566
50ZNF274_21170338_ChIP-Seq_K562_Hela1.41702288
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.40605328
52SMAD4_21799915_ChIP-Seq_A2780_Human1.38680480
53RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38210851
54NANOG_16153702_ChIP-ChIP_HESCs_Human1.36558735
55ETS1_20019798_ChIP-Seq_JURKAT_Human1.36129473
56SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35403300
57STAT3_23295773_ChIP-Seq_U87_Human1.33496662
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31565147
59EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31504074
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29737889
61RXR_22158963_ChIP-Seq_LIVER_Mouse1.29302544
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29280797
63JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.29090287
64E2F4_17652178_ChIP-ChIP_JURKAT_Human1.29075474
65FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.28742996
66HTT_18923047_ChIP-ChIP_STHdh_Human1.28048900
67SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26821689
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26651039
69JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26536767
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25795822
71BCAT_22108803_ChIP-Seq_LS180_Human1.25155748
72P300_19829295_ChIP-Seq_ESCs_Human1.23134644
73* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22405001
74ER_23166858_ChIP-Seq_MCF-7_Human1.22378695
75NANOG_19829295_ChIP-Seq_ESCs_Human1.20869526
76SOX2_19829295_ChIP-Seq_ESCs_Human1.20869526
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18848694
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18040186
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16373969
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15789290
81AR_21909140_ChIP-Seq_LNCAP_Human1.15324280
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14461782
83* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14116852
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.13958368
85EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13091726
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12696162
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12559338
88TCF4_22108803_ChIP-Seq_LS180_Human1.11981708
89CBP_20019798_ChIP-Seq_JUKART_Human1.11330480
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11330480
91VDR_22108803_ChIP-Seq_LS180_Human1.11058787
92IRF1_19129219_ChIP-ChIP_H3396_Human1.10436969
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10094636
94SOX2_21211035_ChIP-Seq_LN229_Gbm1.09456313
95HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09409650
96CRX_20693478_ChIP-Seq_RETINA_Mouse1.09238004
97NANOG_16518401_ChIP-PET_MESCs_Mouse1.09078226
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07743231
99FOXM1_23109430_ChIP-Seq_U2OS_Human1.07519874
100SOX2_16153702_ChIP-ChIP_HESCs_Human1.07092976
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06969595
102SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06522028
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.05399869
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.04787104
105YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04772970
106* TCF4_23295773_ChIP-Seq_U87_Human1.03832326
107ZNF263_19887448_ChIP-Seq_K562_Human1.03514684
108CDX2_22108803_ChIP-Seq_LS180_Human1.03379970
109* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.03179736
110AR_25329375_ChIP-Seq_VCAP_Human1.02621118
111EWS_26573619_Chip-Seq_HEK293_Human1.02045797
112GATA1_26923725_Chip-Seq_HPCs_Mouse1.01934142
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01785711
114* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01326014
115SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99428875
116SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99174833
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98820560
118FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98747852
119SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98330250
120* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98199674
121PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97952117
122P300_18555785_Chip-Seq_ESCs_Mouse0.97789487
123RNF2_27304074_Chip-Seq_NSC_Mouse0.97226582
124DROSHA_22980978_ChIP-Seq_HELA_Human0.97174865
125* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96292637
126* SMAD3_21741376_ChIP-Seq_EPCs_Human0.96081125
127* SMAD4_21741376_ChIP-Seq_EPCs_Human0.95974895
128NFE2_27457419_Chip-Seq_LIVER_Mouse0.95926471
129SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95663231
130NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94100557
131MYC_18555785_ChIP-Seq_MESCs_Mouse0.94065272
132E2F1_18555785_Chip-Seq_ESCs_Mouse0.93567977
133SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.92899371
134STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92553746
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91743763
136ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91244093
137TBX3_20139965_ChIP-Seq_ESCs_Mouse0.91144802
138TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90547020
139TBX3_20139965_ChIP-Seq_MESCs_Mouse0.89717164
140REST_19997604_ChIP-ChIP_NEURONS_Mouse0.88023467
141JUN_21703547_ChIP-Seq_K562_Human0.87349295
142LXR_22158963_ChIP-Seq_LIVER_Mouse0.86366418
143YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86324706
144E2F1_21310950_ChIP-Seq_MCF-7_Human0.85715423
145SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.84708643
146RNF2_18974828_ChIP-Seq_MESCs_Mouse0.84358570
147EZH2_18974828_ChIP-Seq_MESCs_Mouse0.84358570
148AR_19668381_ChIP-Seq_PC3_Human0.84032604
149MTF2_20144788_ChIP-Seq_MESCs_Mouse0.83700694
150TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.83635252
151POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.83237697
152* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.83171503
153P53_22387025_ChIP-Seq_ESCs_Mouse0.82998189
154EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.82659401

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.77002291
2MP0003880_abnormal_central_pattern4.14420790
3MP0008058_abnormal_DNA_repair3.40830512
4MP0003635_abnormal_synaptic_transmissio3.12722293
5MP0004270_analgesia2.82422928
6MP0005360_urolithiasis2.79523249
7MP0002139_abnormal_hepatobiliary_system2.68988428
8MP0003941_abnormal_skin_development2.63793919
9MP0002063_abnormal_learning/memory/cond2.61984236
10MP0009745_abnormal_behavioral_response2.60786292
11MP0010234_abnormal_vibrissa_follicle2.51338086
12MP0005646_abnormal_pituitary_gland2.47715530
13MP0009046_muscle_twitch2.33277963
14MP0003786_premature_aging2.33275609
15MP0005085_abnormal_gallbladder_physiolo2.28465441
16MP0008007_abnormal_cellular_replicative2.27261182
17MP0001968_abnormal_touch/_nociception2.13383811
18MP0002064_seizures2.08628022
19MP0002822_catalepsy2.07391470
20MP0005365_abnormal_bile_salt2.02178345
21MP0002572_abnormal_emotion/affect_behav2.02025378
22MP0008877_abnormal_DNA_methylation1.99790213
23MP0003123_paternal_imprinting1.98612001
24MP0003195_calcinosis1.97400970
25MP0005367_renal/urinary_system_phenotyp1.95420361
26MP0000516_abnormal_urinary_system1.95420361
27MP0001486_abnormal_startle_reflex1.87387665
28MP0006292_abnormal_olfactory_placode1.85832735
29MP0002102_abnormal_ear_morphology1.78112414
30MP0002938_white_spotting1.76969666
31MP0002734_abnormal_mechanical_nocicepti1.76415624
32MP0000372_irregular_coat_pigmentation1.72133252
33MP0002272_abnormal_nervous_system1.71474926
34MP0002254_reproductive_system_inflammat1.71202707
35MP0002735_abnormal_chemical_nociception1.69083121
36MP0008932_abnormal_embryonic_tissue1.69075026
37MP0001501_abnormal_sleep_pattern1.67273777
38MP0002876_abnormal_thyroid_physiology1.66805613
39MP0001440_abnormal_grooming_behavior1.66640804
40MP0003077_abnormal_cell_cycle1.61953445
41MP0002736_abnormal_nociception_after1.61825677
42MP0008872_abnormal_physiological_respon1.61106576
43MP0008875_abnormal_xenobiotic_pharmacok1.58852871
44MP0006276_abnormal_autonomic_nervous1.57219636
45MP0003937_abnormal_limbs/digits/tail_de1.51085620
46MP0002837_dystrophic_cardiac_calcinosis1.50695530
47MP0006054_spinal_hemorrhage1.46417459
48MP0010329_abnormal_lipoprotein_level1.45488026
49MP0001485_abnormal_pinna_reflex1.45251429
50MP0002751_abnormal_autonomic_nervous1.42397939
51MP0002184_abnormal_innervation1.42191424
52MP0003787_abnormal_imprinting1.40852736
53MP0002067_abnormal_sensory_capabilities1.40649851
54MP0001293_anophthalmia1.40205161
55MP0008995_early_reproductive_senescence1.37963742
56MP0005386_behavior/neurological_phenoty1.37458156
57MP0004924_abnormal_behavior1.37458156
58MP0001188_hyperpigmentation1.34990572
59MP0002160_abnormal_reproductive_system1.34061678
60MP0005253_abnormal_eye_physiology1.32118725
61MP0010307_abnormal_tumor_latency1.31643334
62MP0005551_abnormal_eye_electrophysiolog1.31337385
63MP0004215_abnormal_myocardial_fiber1.28360426
64MP0002557_abnormal_social/conspecific_i1.27278059
65MP0003567_abnormal_fetal_cardiomyocyte1.26475705
66MP0004142_abnormal_muscle_tone1.25406327
67MP0004957_abnormal_blastocyst_morpholog1.23596453
68MP0002090_abnormal_vision1.22260949
69MP0002733_abnormal_thermal_nociception1.19374100
70MP0003111_abnormal_nucleus_morphology1.15932594
71MP0003890_abnormal_embryonic-extraembry1.14779914
72MP0003252_abnormal_bile_duct1.12368527
73MP0004811_abnormal_neuron_physiology1.11570855
74MP0005084_abnormal_gallbladder_morpholo1.10244593
75MP0003718_maternal_effect1.10100952
76MP0005645_abnormal_hypothalamus_physiol1.09563814
77MP0006036_abnormal_mitochondrial_physio1.08685291
78MP0003806_abnormal_nucleotide_metabolis1.07205698
79MP0005332_abnormal_amino_acid1.06841568
80MP0003283_abnormal_digestive_organ1.06838307
81MP0000955_abnormal_spinal_cord1.06808001
82MP0009697_abnormal_copulation1.06521001
83MP0010094_abnormal_chromosome_stability1.05419354
84MP0000647_abnormal_sebaceous_gland1.05274704
85MP0009780_abnormal_chondrocyte_physiolo1.03155697
86MP0005423_abnormal_somatic_nervous1.02789423
87MP0001970_abnormal_pain_threshold1.02544165
88MP0002909_abnormal_adrenal_gland1.02524169
89MP0005395_other_phenotype1.01861440
90MP0004133_heterotaxia1.01836165
91MP0010352_gastrointestinal_tract_polyps1.00877358
92MP0004147_increased_porphyrin_level0.99861440
93MP0001529_abnormal_vocalization0.98890424
94MP0002066_abnormal_motor_capabilities/c0.97221544
95MP0003122_maternal_imprinting0.97211453
96MP0005535_abnormal_body_temperature0.97163664
97MP0005389_reproductive_system_phenotype0.96411535
98MP0004043_abnormal_pH_regulation0.95809750
99MP0002233_abnormal_nose_morphology0.95604872
100MP0005187_abnormal_penis_morphology0.94930402
101MP0004019_abnormal_vitamin_homeostasis0.94178392
102MP0003137_abnormal_impulse_conducting0.94024788
103MP0002069_abnormal_eating/drinking_beha0.93528082
104MP0003329_amyloid_beta_deposits0.93090224
105MP0003121_genomic_imprinting0.93030637
106MP0003879_abnormal_hair_cell0.92957793
107MP0002210_abnormal_sex_determination0.92493861
108MP0001145_abnormal_male_reproductive0.91990706
109MP0010386_abnormal_urinary_bladder0.91379423
110MP0000778_abnormal_nervous_system0.91217195
111MP0005075_abnormal_melanosome_morpholog0.90512775
112MP0003698_abnormal_male_reproductive0.90452691
113MP0006072_abnormal_retinal_apoptosis0.90329008
114MP0001177_atelectasis0.89129390
115MP0002152_abnormal_brain_morphology0.88555516
116MP0002084_abnormal_developmental_patter0.87886428
117MP0008789_abnormal_olfactory_epithelium0.87181282
118MP0009703_decreased_birth_body0.87089867
119MP0002277_abnormal_respiratory_mucosa0.87044983
120MP0001119_abnormal_female_reproductive0.86728318
121MP0005379_endocrine/exocrine_gland_phen0.86205096
122MP0005451_abnormal_body_composition0.85510468
123MP0002282_abnormal_trachea_morphology0.84970540
124MP0001697_abnormal_embryo_size0.84771545
125MP0001286_abnormal_eye_development0.84263435
126MP0005410_abnormal_fertilization0.83679517
127MP0000613_abnormal_salivary_gland0.83545689
128MP0006035_abnormal_mitochondrial_morpho0.83153127
129MP0002882_abnormal_neuron_morphology0.82528884
130MP0008874_decreased_physiological_sensi0.82005229
131MP0001929_abnormal_gametogenesis0.80317469
132MP0003119_abnormal_digestive_system0.79958084
133MP0000427_abnormal_hair_cycle0.78981861
134MP0004885_abnormal_endolymph0.77400512
135MP0008057_abnormal_DNA_replication0.77285022
136MP0002638_abnormal_pupillary_reflex0.76046914
137MP0010678_abnormal_skin_adnexa0.75677954
138MP0003186_abnormal_redox_activity0.75216891
139MP0002078_abnormal_glucose_homeostasis0.74220531
140MP0001984_abnormal_olfaction0.74006197
141MP0002085_abnormal_embryonic_tissue0.73570731
142MP0009672_abnormal_birth_weight0.72475989
143MP0002161_abnormal_fertility/fecundity0.71658949
144MP0001730_embryonic_growth_arrest0.71592519
145MP0000678_abnormal_parathyroid_gland0.71438421
146MP0005220_abnormal_exocrine_pancreas0.71312847
147MP0002163_abnormal_gland_morphology0.71243025
148MP0002234_abnormal_pharynx_morphology0.71066500
149MP0000358_abnormal_cell_content/0.70934865
150MP0003755_abnormal_palate_morphology0.70361671
151MP0001672_abnormal_embryogenesis/_devel0.69513710
152MP0005380_embryogenesis_phenotype0.69513710
153MP0000653_abnormal_sex_gland0.69414365
154MP0003011_delayed_dark_adaptation0.69113163
155MP0003693_abnormal_embryo_hatching0.69083413
156MP0002118_abnormal_lipid_homeostasis0.68236076
157MP0001764_abnormal_homeostasis0.68034381
158MP0005647_abnormal_sex_gland0.67922938
159MP0004233_abnormal_muscle_weight0.67709667
160MP0003632_abnormal_nervous_system0.66729255
161MP0000631_abnormal_neuroendocrine_gland0.66348071
162MP0005266_abnormal_metabolism0.66230846
163MP0003631_nervous_system_phenotype0.66222356

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.93497992
2Oligodactyly (hands) (HP:0001180)3.80297052
3Visual hallucinations (HP:0002367)3.77724636
4Focal seizures (HP:0007359)3.76281294
5Abnormality of the lower motor neuron (HP:0002366)3.68773232
6Myokymia (HP:0002411)3.65184416
7Abnormality of chromosome stability (HP:0003220)3.39683723
8Methylmalonic acidemia (HP:0002912)3.31728446
9Colon cancer (HP:0003003)3.22049355
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.16563896
11Absence seizures (HP:0002121)3.16238407
12Hypobetalipoproteinemia (HP:0003563)3.11716256
13Meckel diverticulum (HP:0002245)3.09535296
14Aplasia/Hypoplasia of the uvula (HP:0010293)3.04560879
15Hyperventilation (HP:0002883)3.03173914
16Generalized tonic-clonic seizures (HP:0002069)3.02684835
17Chromsome breakage (HP:0040012)3.02286820
18Abnormality of the labia minora (HP:0012880)3.00967288
19Abnormality of the ileum (HP:0001549)2.99640703
20Status epilepticus (HP:0002133)2.90232873
21Epileptic encephalopathy (HP:0200134)2.89526100
22Febrile seizures (HP:0002373)2.87484753
23Intrahepatic cholestasis (HP:0001406)2.84815926
24Dialeptic seizures (HP:0011146)2.84242320
25Pancreatic islet-cell hyperplasia (HP:0004510)2.83372999
26Abnormality of aromatic amino acid family metabolism (HP:0004338)2.82539075
27Poor eye contact (HP:0000817)2.82470474
28Volvulus (HP:0002580)2.81994756
29Atonic seizures (HP:0010819)2.75339538
30Impaired smooth pursuit (HP:0007772)2.70512554
31Impaired vibration sensation in the lower limbs (HP:0002166)2.69925205
32Abnormality of the preputium (HP:0100587)2.68802991
33Pancreatic cysts (HP:0001737)2.63947639
34Hyperglycinemia (HP:0002154)2.63834869
35Oligodactyly (HP:0012165)2.63601055
36Abnormality of monocarboxylic acid metabolism (HP:0010996)2.62545428
37Glioma (HP:0009733)2.61999156
38Hypoglycemic seizures (HP:0002173)2.59610233
39Epileptiform EEG discharges (HP:0011182)2.59518764
40Intestinal atresia (HP:0011100)2.58002590
41Resting tremor (HP:0002322)2.55661601
42Hypothermia (HP:0002045)2.55369887
43Impaired social interactions (HP:0000735)2.54183163
44Abnormal social behavior (HP:0012433)2.54183163
45Progressive inability to walk (HP:0002505)2.53182248
46Postural instability (HP:0002172)2.51778553
47EEG with generalized epileptiform discharges (HP:0011198)2.51239695
48Neoplasm of the adrenal gland (HP:0100631)2.48952017
49Methylmalonic aciduria (HP:0012120)2.47365046
50Hyperinsulinemic hypoglycemia (HP:0000825)2.45618498
51Neoplasm of the adrenal cortex (HP:0100641)2.45517209
52Abnormal lung lobation (HP:0002101)2.45204982
53Hypsarrhythmia (HP:0002521)2.43373745
54Protruding tongue (HP:0010808)2.39932375
55Spastic diplegia (HP:0001264)2.39012154
56Hyperglycinuria (HP:0003108)2.35532546
57Abnormality of ocular smooth pursuit (HP:0000617)2.35368165
58Small intestinal stenosis (HP:0012848)2.34237263
59Duodenal stenosis (HP:0100867)2.34237263
60Pancreatic fibrosis (HP:0100732)2.34161357
61Abnormality of the duodenum (HP:0002246)2.33048724
62True hermaphroditism (HP:0010459)2.32442731
63Ectopic kidney (HP:0000086)2.30175968
64Abolished electroretinogram (ERG) (HP:0000550)2.28101860
65Ependymoma (HP:0002888)2.26629587
66Amyotrophic lateral sclerosis (HP:0007354)2.26300151
67Aqueductal stenosis (HP:0002410)2.25441933
68Abnormality of vitamin B metabolism (HP:0004340)2.24351519
69Drooling (HP:0002307)2.24333855
70Excessive salivation (HP:0003781)2.24333855
71Dysdiadochokinesis (HP:0002075)2.23850083
72Delayed CNS myelination (HP:0002188)2.22222678
73Acute encephalopathy (HP:0006846)2.21673677
74Tetraplegia (HP:0002445)2.21270488
75Breast carcinoma (HP:0003002)2.20788223
76Progressive macrocephaly (HP:0004481)2.20479590
77Abnormality of the vitamin B12 metabolism (HP:0004341)2.17974029
78Bradykinesia (HP:0002067)2.16299114
79Abnormality of glycine metabolism (HP:0010895)2.15973030
80Abnormality of serine family amino acid metabolism (HP:0010894)2.15973030
81Epidermoid cyst (HP:0200040)2.15768924
82Hypolipoproteinemia (HP:0010981)2.15425238
83Abnormality of pyrimidine metabolism (HP:0004353)2.15292896
84Acute necrotizing encephalopathy (HP:0006965)2.15009070
85Gaze-evoked nystagmus (HP:0000640)2.13272128
86Sloping forehead (HP:0000340)2.11822997
87Deep venous thrombosis (HP:0002625)2.10959758
88Hypoglycemic coma (HP:0001325)2.10056231
89Hyperammonemia (HP:0001987)2.07638865
90Nephroblastoma (Wilms tumor) (HP:0002667)2.07004850
91Impaired vibratory sensation (HP:0002495)2.06771010
92Pendular nystagmus (HP:0012043)2.05677274
93Embryonal renal neoplasm (HP:0011794)2.05476592
94Abnormality of endocrine pancreas physiology (HP:0012093)2.03873737
95Abnormality of the pancreatic islet cells (HP:0006476)2.03873737
96Abnormality of aspartate family amino acid metabolism (HP:0010899)2.02887143
97Abnormality of methionine metabolism (HP:0010901)2.02731751
98Progressive cerebellar ataxia (HP:0002073)2.00743622
99Fair hair (HP:0002286)2.00651180
100Ketosis (HP:0001946)2.00238571
101Clubbing of toes (HP:0100760)1.99317203
102Posterior subcapsular cataract (HP:0007787)1.98675010
103Supernumerary spleens (HP:0009799)1.98527542
104Rhabdomyosarcoma (HP:0002859)1.98089979
105Amblyopia (HP:0000646)1.97405010
106Medial flaring of the eyebrow (HP:0010747)1.96869839
107Astrocytoma (HP:0009592)1.96765190
108Abnormality of the astrocytes (HP:0100707)1.96765190
109Absent radius (HP:0003974)1.95439143
110Increased CSF lactate (HP:0002490)1.95083406
111Agnosia (HP:0010524)1.93846678
112Split foot (HP:0001839)1.93593557
113Abnormality of sulfur amino acid metabolism (HP:0004339)1.93483788
114Depression (HP:0000716)1.92973014
115Absent speech (HP:0001344)1.92659721
116Gonadotropin excess (HP:0000837)1.91202127
117Medulloblastoma (HP:0002885)1.90951496
118Termporal pattern (HP:0011008)1.90599991
119Insidious onset (HP:0003587)1.90599991
120Delayed myelination (HP:0012448)1.90098962
121Sensory axonal neuropathy (HP:0003390)1.89829385
122Small hand (HP:0200055)1.89676863
123Increased circulating renin level (HP:0000848)1.89143649
124Abnormality of serum amino acid levels (HP:0003112)1.88698543
125Horseshoe kidney (HP:0000085)1.88346760
126Xanthomatosis (HP:0000991)1.85667824
127Urinary bladder sphincter dysfunction (HP:0002839)1.84892120
128Action tremor (HP:0002345)1.84733717
129Anxiety (HP:0000739)1.84547040
130Ketoacidosis (HP:0001993)1.84538824
131Homocystinuria (HP:0002156)1.84522139
132Abnormality of homocysteine metabolism (HP:0010919)1.84522139
133Ovarian neoplasm (HP:0100615)1.83757233
134Scanning speech (HP:0002168)1.83475672
135Aplasia involving forearm bones (HP:0009822)1.82701264
136Absent forearm bone (HP:0003953)1.82701264
137Conjugated hyperbilirubinemia (HP:0002908)1.82506571
138Genital tract atresia (HP:0001827)1.82264610
139Abnormality of midbrain morphology (HP:0002418)1.81813098
140Molar tooth sign on MRI (HP:0002419)1.81813098
141Gout (HP:0001997)1.80986076
142Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.79884641
143Septo-optic dysplasia (HP:0100842)1.79502529
144Generalized myoclonic seizures (HP:0002123)1.79394710
145Horizontal nystagmus (HP:0000666)1.78556722
146Hypoplastic pelvis (HP:0008839)1.78527091
147Abnormality of the parathyroid morphology (HP:0011766)1.78150519
148Stenosis of the external auditory canal (HP:0000402)1.77972763
149Thyroiditis (HP:0100646)1.77928062
150Birth length less than 3rd percentile (HP:0003561)1.76364093
151Symptomatic seizures (HP:0011145)1.76203848
152Biliary tract neoplasm (HP:0100574)1.75761191
153Focal dystonia (HP:0004373)1.75473996
154Nephronophthisis (HP:0000090)1.74816736
155Vaginal atresia (HP:0000148)1.74816655
156Mitochondrial inheritance (HP:0001427)1.74520151
157Broad-based gait (HP:0002136)1.74339338
158Aplasia/Hypoplasia of the tongue (HP:0010295)1.74090096
159Absent thumb (HP:0009777)1.73753140
160Hypogonadotrophic hypogonadism (HP:0000044)1.73231790
161Generalized hypopigmentation of hair (HP:0011358)1.72532028
162Neoplasm of the oral cavity (HP:0100649)1.72111345
163Abnormal eating behavior (HP:0100738)1.71696724
164Prolonged partial thromboplastin time (HP:0003645)1.71395587
165Triphalangeal thumb (HP:0001199)1.71224851
166Prominent metopic ridge (HP:0005487)1.71023888
167Delusions (HP:0000746)1.70376180
168Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.70216994
169Hypochromic microcytic anemia (HP:0004840)1.69962428
170Ankyloglossia (HP:0010296)1.69446031
171Spastic tetraplegia (HP:0002510)1.69208134
172Carpal bone hypoplasia (HP:0001498)1.68610628
173Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68505034
174Abnormality of the renal cortex (HP:0011035)1.68317351
175Adrenal hypoplasia (HP:0000835)1.68223259
176Torticollis (HP:0000473)1.68108289
177Dandy-Walker malformation (HP:0001305)1.67690027
178Hyperlipoproteinemia (HP:0010980)1.65254681
179Confusion (HP:0001289)1.64829605
180Abnormal mitochondria in muscle tissue (HP:0008316)1.64797217
181Megaloblastic anemia (HP:0001889)1.64591741
182Aplasia/Hypoplasia of the hallux (HP:0008362)1.64248568
183Truncal ataxia (HP:0002078)1.63342120
184Hypoalphalipoproteinemia (HP:0003233)1.63233725
185Neoplasm of striated muscle (HP:0009728)1.62015343
186Spastic gait (HP:0002064)1.61930372

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.27682697
2EPHA44.06802203
3TRIM283.65530021
4MAP3K43.40718795
5MST43.18114975
6MAP3K93.04385561
7EIF2AK32.92743899
8NUAK12.87071960
9MAP2K72.65940052
10DAPK22.54588056
11KSR22.42566233
12MAP2K42.42024902
13PNCK2.40090315
14MKNK12.34690874
15TNIK2.33892388
16BMPR1B2.32134382
17EIF2AK12.18826595
18BRSK22.09255951
19MARK12.05813369
20ZAK2.01868550
21CASK2.01351334
22ERBB31.97029529
23CDC71.91805898
24SCYL21.82634534
25PLK41.80236600
26DAPK11.80182958
27KSR11.75697002
28MINK11.75477011
29WNK31.75396313
30PBK1.65497733
31NTRK21.61209511
32MAP3K61.50639338
33NEK11.48234930
34GRK11.45810982
35VRK21.45639417
36ERBB41.45447115
37LATS21.44063204
38TTK1.43278210
39STK391.41690520
40OXSR11.41677013
41MAP4K21.41258383
42WEE11.41206405
43SGK21.40924577
44TAF11.38074027
45PRKD31.38056534
46PDK31.31907042
47PDK41.31907042
48VRK11.28555119
49BRAF1.27859705
50MAP3K21.27510438
51ARAF1.26849339
52FGFR21.25123119
53RAF11.24098291
54PRKCG1.22451941
55PAK61.16894913
56PAK31.11616927
57PINK11.06204235
58BCR1.03214894
59STK161.02514397
60PLK31.02154936
61STK381.02141585
62SGK2230.99526719
63SGK4940.99526719
64EIF2AK20.99360414
65CAMKK10.99350691
66CSNK1G10.99220752
67CDK50.97868448
68AKT30.94651295
69TYRO30.94378651
70NTRK10.94357926
71SGK30.92345980
72STK30.90318773
73PLK20.89356411
74CAMK1D0.87098670
75MAP3K130.86859438
76RIPK40.86294919
77ALK0.86210664
78SIK30.84575973
79RET0.84308825
80FRK0.81310363
81MAPK130.79362077
82NLK0.78476831
83ADRBK20.78159948
84TGFBR10.76613197
85TSSK60.74710031
86FER0.74168611
87GRK50.72926354
88MAP3K120.72329706
89FGFR10.71633351
90BCKDK0.71384426
91CSNK1G30.70524051
92ATR0.70120544
93TNK20.66931925
94PRKCI0.65909310
95SGK10.64713376
96CAMK2A0.64132010
97RPS6KB10.63629604
98PRKCE0.62648868
99PLK10.61489699
100STK38L0.60661877
101BRSK10.58705911
102CSNK1E0.58656183
103CCNB10.58622832
104STK110.57940363
105MELK0.57718121
106CSNK1A1L0.56597996
107CSNK1G20.55273880
108CAMK1G0.53971153
109STK240.53953808
110MKNK20.52097762
111PDK20.51703891
112CDK180.51405150
113LATS10.51202911
114CHEK20.50685440
115CDK150.50604356
116FES0.49731361
117BMPR20.49135275
118NEK20.47964915
119PASK0.46767488
120AURKA0.46351126
121RPS6KA30.44385754
122ACVR1B0.44378041
123CDK140.43643883
124MAPK100.42739821
125CHEK10.42484429
126CSNK1D0.41863252
127ATM0.41672814
128NME10.40966232
129CDK11A0.39581316
130ABL20.39376189
131CDK120.38742615
132CDK20.38684753
133SRPK10.38000917
134INSRR0.37814239
135AURKB0.37749795
136CDK80.37200733
137STK100.36409176
138CDK90.35755611
139TIE10.35404014
140FLT30.35268396
141DYRK1A0.35226711
142BUB10.34914863
143MAP2K10.34020464
144CAMK2B0.33630526
145CSNK2A10.33393240
146CDK10.33278887
147DYRK20.33104291
148STK40.32621551
149TEC0.30281799
150PRKDC0.29971008
151MAPKAPK50.27988494
152WNK40.27932554
153YES10.25293907
154CSNK1A10.23908284
155CSNK2A20.23165442
156BRD40.22551450
157PHKG20.21359115
158PHKG10.21359115
159TLK10.20068208
160ADRBK10.19293670
161MUSK0.19132392

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.71428645
2Nitrogen metabolism_Homo sapiens_hsa009103.42291460
3Non-homologous end-joining_Homo sapiens_hsa034503.37619984
4Protein export_Homo sapiens_hsa030603.22236568
5Nicotine addiction_Homo sapiens_hsa050333.16161948
6Homologous recombination_Homo sapiens_hsa034402.76317291
7Arginine biosynthesis_Homo sapiens_hsa002202.32976488
8Synaptic vesicle cycle_Homo sapiens_hsa047212.32707194
9Fanconi anemia pathway_Homo sapiens_hsa034602.31296100
10Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.30431046
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.29875632
12Long-term potentiation_Homo sapiens_hsa047202.29865188
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.25848792
14Primary bile acid biosynthesis_Homo sapiens_hsa001202.21640688
15DNA replication_Homo sapiens_hsa030302.19630131
16RNA polymerase_Homo sapiens_hsa030202.09960794
17Basal transcription factors_Homo sapiens_hsa030222.08416888
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.94948664
19Amphetamine addiction_Homo sapiens_hsa050311.94104937
20GABAergic synapse_Homo sapiens_hsa047271.93665318
21Glutamatergic synapse_Homo sapiens_hsa047241.90515450
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.78783570
23Steroid biosynthesis_Homo sapiens_hsa001001.73702499
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.73312001
25Circadian entrainment_Homo sapiens_hsa047131.71946503
26Olfactory transduction_Homo sapiens_hsa047401.70266238
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.68747045
28Morphine addiction_Homo sapiens_hsa050321.68069227
29Insulin secretion_Homo sapiens_hsa049111.64012098
30Fatty acid elongation_Homo sapiens_hsa000621.60952523
31Dopaminergic synapse_Homo sapiens_hsa047281.54984832
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52586326
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.50521925
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48367448
35Butanoate metabolism_Homo sapiens_hsa006501.47882299
36Cell cycle_Homo sapiens_hsa041101.40893580
37Nucleotide excision repair_Homo sapiens_hsa034201.39824220
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39137314
39Vitamin B6 metabolism_Homo sapiens_hsa007501.35753212
40Oocyte meiosis_Homo sapiens_hsa041141.35472195
41Pyruvate metabolism_Homo sapiens_hsa006201.32229825
42Tryptophan metabolism_Homo sapiens_hsa003801.30881729
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.28787494
44Taste transduction_Homo sapiens_hsa047421.28487936
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.28455355
46Oxidative phosphorylation_Homo sapiens_hsa001901.26732887
47Salivary secretion_Homo sapiens_hsa049701.24785521
48Long-term depression_Homo sapiens_hsa047301.23061852
49Propanoate metabolism_Homo sapiens_hsa006401.22747214
50Fatty acid biosynthesis_Homo sapiens_hsa000611.22303144
51Base excision repair_Homo sapiens_hsa034101.19396943
52Bile secretion_Homo sapiens_hsa049761.17537827
53One carbon pool by folate_Homo sapiens_hsa006701.16437545
54Phototransduction_Homo sapiens_hsa047441.16385539
55Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15175767
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14556671
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13593581
58Biosynthesis of amino acids_Homo sapiens_hsa012301.11628386
59beta-Alanine metabolism_Homo sapiens_hsa004101.09303296
60Parkinsons disease_Homo sapiens_hsa050121.08794730
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07781718
62Glucagon signaling pathway_Homo sapiens_hsa049221.05924840
63Caffeine metabolism_Homo sapiens_hsa002321.04269055
64Purine metabolism_Homo sapiens_hsa002301.02975637
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02014013
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00315752
67Renin secretion_Homo sapiens_hsa049240.99760055
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99507007
69Glutathione metabolism_Homo sapiens_hsa004800.98372148
70Spliceosome_Homo sapiens_hsa030400.98145920
71Serotonergic synapse_Homo sapiens_hsa047260.97878683
72Cholinergic synapse_Homo sapiens_hsa047250.96847290
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96020742
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95015084
75Fatty acid degradation_Homo sapiens_hsa000710.93048765
76Sulfur metabolism_Homo sapiens_hsa009200.91019053
77Pyrimidine metabolism_Homo sapiens_hsa002400.89641102
78Type II diabetes mellitus_Homo sapiens_hsa049300.88143922
79Calcium signaling pathway_Homo sapiens_hsa040200.87723795
80GnRH signaling pathway_Homo sapiens_hsa049120.86310709
81Gastric acid secretion_Homo sapiens_hsa049710.85720363
82Oxytocin signaling pathway_Homo sapiens_hsa049210.85102764
83Dorso-ventral axis formation_Homo sapiens_hsa043200.83883186
84p53 signaling pathway_Homo sapiens_hsa041150.83698946
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83568953
86Cocaine addiction_Homo sapiens_hsa050300.81548163
87Vitamin digestion and absorption_Homo sapiens_hsa049770.80894832
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79411314
89Estrogen signaling pathway_Homo sapiens_hsa049150.75660164
90PPAR signaling pathway_Homo sapiens_hsa033200.75499916
91Glycerolipid metabolism_Homo sapiens_hsa005610.75167002
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74942979
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.74494436
94Collecting duct acid secretion_Homo sapiens_hsa049660.73645832
95mRNA surveillance pathway_Homo sapiens_hsa030150.71200194
96Huntingtons disease_Homo sapiens_hsa050160.70002913
97Phenylalanine metabolism_Homo sapiens_hsa003600.69570653
98Fatty acid metabolism_Homo sapiens_hsa012120.69563219
99Melanogenesis_Homo sapiens_hsa049160.69376853
100cAMP signaling pathway_Homo sapiens_hsa040240.69262407
101Carbon metabolism_Homo sapiens_hsa012000.69103354
102Peroxisome_Homo sapiens_hsa041460.68633798
103Alcoholism_Homo sapiens_hsa050340.66863076
104Ether lipid metabolism_Homo sapiens_hsa005650.66105278
105Regulation of autophagy_Homo sapiens_hsa041400.66023816
106Histidine metabolism_Homo sapiens_hsa003400.65283829
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.64659045
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64375541
109Metabolic pathways_Homo sapiens_hsa011000.63901155
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61371669
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61366760
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60362041
113TGF-beta signaling pathway_Homo sapiens_hsa043500.60355664
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59881934
115RNA transport_Homo sapiens_hsa030130.59431133
116Gap junction_Homo sapiens_hsa045400.59278494
117Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57829060
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57569666
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.57103302
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56846677
121Glioma_Homo sapiens_hsa052140.54712596
122Chemical carcinogenesis_Homo sapiens_hsa052040.54366069
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.53988745
124Retinol metabolism_Homo sapiens_hsa008300.53527933
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52639111
126Selenocompound metabolism_Homo sapiens_hsa004500.51929824
127Alzheimers disease_Homo sapiens_hsa050100.51771660
128Folate biosynthesis_Homo sapiens_hsa007900.51740499
129Mismatch repair_Homo sapiens_hsa034300.50118595
130Choline metabolism in cancer_Homo sapiens_hsa052310.50031153
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49938658
132Wnt signaling pathway_Homo sapiens_hsa043100.49715076
133N-Glycan biosynthesis_Homo sapiens_hsa005100.49534013
134mTOR signaling pathway_Homo sapiens_hsa041500.48733570
135Hedgehog signaling pathway_Homo sapiens_hsa043400.48702893
136Tyrosine metabolism_Homo sapiens_hsa003500.48312448
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48216469
138Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48163959
139Thyroid hormone synthesis_Homo sapiens_hsa049180.47979390
140Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47975941
141Linoleic acid metabolism_Homo sapiens_hsa005910.47621122
142ErbB signaling pathway_Homo sapiens_hsa040120.45976848
143Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45791161
144Hippo signaling pathway_Homo sapiens_hsa043900.45172450
145Complement and coagulation cascades_Homo sapiens_hsa046100.44901945
146cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42722027
147Steroid hormone biosynthesis_Homo sapiens_hsa001400.42121256
148RNA degradation_Homo sapiens_hsa030180.41604578
149Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41216670
150Inositol phosphate metabolism_Homo sapiens_hsa005620.41156137
151Fat digestion and absorption_Homo sapiens_hsa049750.40144883
152Arginine and proline metabolism_Homo sapiens_hsa003300.37886386
153Circadian rhythm_Homo sapiens_hsa047100.37336320
154alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35092317
155Tight junction_Homo sapiens_hsa045300.33341904
156Basal cell carcinoma_Homo sapiens_hsa052170.33264430
157Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26417448

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