BAG3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)6.98109734
2plasma membrane repair (GO:0001778)6.05696437
3negative regulation of inclusion body assembly (GO:0090084)5.99690055
4cardiac myofibril assembly (GO:0055003)5.92082922
5muscle filament sliding (GO:0030049)5.58310663
6actin-myosin filament sliding (GO:0033275)5.58310663
7negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.54640148
8myofibril assembly (GO:0030239)5.49970597
9protein refolding (GO:0042026)5.29432031
10bundle of His cell to Purkinje myocyte communication (GO:0086069)5.12015977
11regulation of skeletal muscle contraction (GO:0014819)5.03532537
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.00958308
13negative regulation of potassium ion transmembrane transport (GO:1901380)4.94759502
14hemidesmosome assembly (GO:0031581)4.86929321
15actin-mediated cell contraction (GO:0070252)4.77724825
16cardiac muscle cell development (GO:0055013)4.64412515
17actomyosin structure organization (GO:0031032)4.40071129
18cardiac cell development (GO:0055006)4.39509690
19cardiac muscle contraction (GO:0060048)4.38911795
20regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.36736173
21regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.35925157
22heart trabecula formation (GO:0060347)4.33652797
23carnitine shuttle (GO:0006853)4.30129689
24cardiac muscle tissue morphogenesis (GO:0055008)4.27052077
25tricarboxylic acid cycle (GO:0006099)4.24832436
26ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.22579664
27chaperone mediated protein folding requiring cofactor (GO:0051085)4.18785578
28regulation of actin filament-based movement (GO:1903115)4.12137046
29ventricular cardiac muscle cell action potential (GO:0086005)4.10073172
30regulation of relaxation of muscle (GO:1901077)4.00285752
31cell-substrate junction assembly (GO:0007044)3.97615619
32muscle tissue morphogenesis (GO:0060415)3.93465014
33fatty acid transmembrane transport (GO:1902001)3.93239035
34skin morphogenesis (GO:0043589)3.91960776
35regulation of inclusion body assembly (GO:0090083)3.81256000
36cell-substrate adherens junction assembly (GO:0007045)3.73434245
37focal adhesion assembly (GO:0048041)3.73434245
38adult heart development (GO:0007512)3.71870863
39response to muscle activity (GO:0014850)3.70413968
40actin filament-based movement (GO:0030048)3.66881321
41sarcoplasmic reticulum calcium ion transport (GO:0070296)3.66834754
42regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.65146320
43regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.64742026
44adherens junction assembly (GO:0034333)3.62764666
45regulation of sequestering of triglyceride (GO:0010889)3.61931938
46striated muscle contraction (GO:0006941)3.54866261
47negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.50696999
48regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.49826295
49Golgi transport vesicle coating (GO:0048200)3.44830063
50COPI coating of Golgi vesicle (GO:0048205)3.44830063
51regulation of striated muscle contraction (GO:0006942)3.37065553
52heart process (GO:0003015)3.34091064
53heart contraction (GO:0060047)3.34091064
54cellular response to arsenic-containing substance (GO:0071243)3.31469381
55regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.29733714
56cardiac muscle hypertrophy (GO:0003300)3.27051458
57negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.26714098
58striated muscle hypertrophy (GO:0014897)3.26033705
59muscle cell cellular homeostasis (GO:0046716)3.24286951
60regulation of fatty acid oxidation (GO:0046320)3.23765142
61regulation of cell communication by electrical coupling (GO:0010649)3.23270554
62carnitine transmembrane transport (GO:1902603)3.21583480
63trabecula formation (GO:0060343)3.20850636
64regulation of cardioblast differentiation (GO:0051890)3.20373901
65dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.19818665
66regulation of p38MAPK cascade (GO:1900744)3.19283649
672-oxoglutarate metabolic process (GO:0006103)3.19244295
68regulation of the force of heart contraction (GO:0002026)3.17212914
69response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.14619684
70creatine metabolic process (GO:0006600)3.09571422
71epithelial cell-cell adhesion (GO:0090136)3.09107968
72desmosome organization (GO:0002934)3.04935628
73cell communication involved in cardiac conduction (GO:0086065)3.01965356
74atrioventricular valve morphogenesis (GO:0003181)3.01683541
75regulation of tight junction assembly (GO:2000810)2.97826670
76positive regulation of fatty acid oxidation (GO:0046321)2.97390707
77muscle hypertrophy (GO:0014896)2.96872637
78regulation of early endosome to late endosome transport (GO:2000641)2.95500968
79amino-acid betaine transport (GO:0015838)2.94286114
80carnitine transport (GO:0015879)2.94286114
81vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.93518141
82fatty acid beta-oxidation (GO:0006635)2.89853599
83glucan biosynthetic process (GO:0009250)2.86112375
84glycogen biosynthetic process (GO:0005978)2.86112375
85positive regulation of p38MAPK cascade (GO:1900745)2.84201139
86regulation of sarcomere organization (GO:0060297)2.83846297
87skeletal muscle adaptation (GO:0043501)2.83293706
88muscle contraction (GO:0006936)2.79541748
89regulation of acyl-CoA biosynthetic process (GO:0050812)2.78671534
90NADH metabolic process (GO:0006734)2.78611655
91response to unfolded protein (GO:0006986)2.78461036
92endothelial cell chemotaxis (GO:0035767)2.78236013
93positive regulation of blood vessel endothelial cell migration (GO:0043536)2.77858379
94vascular endothelial growth factor signaling pathway (GO:0038084)2.77568469
95regulation of cardiac muscle cell contraction (GO:0086004)2.77528263
96striated muscle cell development (GO:0055002)2.76174819
97lysine catabolic process (GO:0006554)2.75857499
98lysine metabolic process (GO:0006553)2.75857499
99positive regulation of fatty acid beta-oxidation (GO:0032000)2.74464313
100protein hydroxylation (GO:0018126)2.73792054
101regulation of cardiac muscle contraction (GO:0055117)2.72913319
102regulation of membrane repolarization (GO:0060306)2.72099550
103regulation of water loss via skin (GO:0033561)2.71263374
104regulation of ATP catabolic process (GO:1903289)2.70219507
105regulation of ATPase activity (GO:0043462)2.70219507
106regulation of heart rate (GO:0002027)2.69231866
107positive regulation of heart contraction (GO:0045823)2.68415926
108negative regulation of cardiac muscle tissue growth (GO:0055022)2.67810511
109negative regulation of heart growth (GO:0061117)2.67810511
110negative regulation of chondrocyte differentiation (GO:0032331)2.67551515
1114-hydroxyproline metabolic process (GO:0019471)2.67165552
112positive regulation of astrocyte differentiation (GO:0048711)2.66762628
113skeletal muscle contraction (GO:0003009)2.66611621
114mammary gland epithelial cell proliferation (GO:0033598)2.65225862
115cell adhesion mediated by integrin (GO:0033627)2.65035472
116skeletal muscle fiber development (GO:0048741)2.64130198
117regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.61587434
118muscle system process (GO:0003012)2.61236108
119ventricular cardiac muscle cell development (GO:0055015)2.60859040
120maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.60590633
121response to topologically incorrect protein (GO:0035966)2.59883322
122peptidyl-proline hydroxylation (GO:0019511)2.59340189
123oxygen transport (GO:0015671)2.58382649
124regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.57845745
125negative regulation of potassium ion transport (GO:0043267)2.57597831
126cardiac muscle cell action potential involved in contraction (GO:0086002)2.57593811
127basement membrane organization (GO:0071711)2.57386625
128endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.57316215
129ER overload response (GO:0006983)2.54640002
130cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.54535529
131positive regulation of lipid storage (GO:0010884)2.54410494
132regulation of cofactor metabolic process (GO:0051193)2.54222195
133regulation of coenzyme metabolic process (GO:0051196)2.54222195
134aspartate family amino acid catabolic process (GO:0009068)2.53581029
135protein localization to endosome (GO:0036010)2.52474491
136kidney mesenchyme development (GO:0072074)2.51535361
137positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.48172446
138wound healing, spreading of epidermal cells (GO:0035313)2.47994449
139heart valve morphogenesis (GO:0003179)2.47351396
140cytoskeletal anchoring at plasma membrane (GO:0007016)2.44893151
141keratinocyte proliferation (GO:0043616)2.44401528
142gluconeogenesis (GO:0006094)2.43345620
143negative regulation of homotypic cell-cell adhesion (GO:0034111)2.41228675
144cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.40126797
145muscle cell migration (GO:0014812)2.39875879
146regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.36695041
147negative regulation of myoblast differentiation (GO:0045662)2.34646760
148retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.34329679
149glomerular basement membrane development (GO:0032836)2.31078548
150regulation of transforming growth factor beta2 production (GO:0032909)2.30607696
151hexose biosynthetic process (GO:0019319)2.29782424
152protein heterotrimerization (GO:0070208)2.29438045
153planar cell polarity pathway involved in neural tube closure (GO:0090179)2.29282726
154myoblast fusion (GO:0007520)2.29049924
155positive regulation of extracellular matrix organization (GO:1903055)2.27748786
156protein retention in ER lumen (GO:0006621)2.27308133
157regulation of myoblast differentiation (GO:0045661)2.27287117
158endodermal cell differentiation (GO:0035987)2.26980430

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.40865434
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.25701910
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.83205496
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.61526930
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.44094678
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.40515135
7CLOCK_20551151_ChIP-Seq_293T_Human2.90917260
8EP300_21415370_ChIP-Seq_HL-1_Mouse2.75474796
9ZNF263_19887448_ChIP-Seq_K562_Human2.59096917
10* TBX20_22328084_ChIP-Seq_HEART_Mouse2.55142415
11* TBX20_22080862_ChIP-Seq_HEART_Mouse2.55142415
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.53287402
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.53014597
14TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.51297275
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.46310383
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.43638122
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.31046145
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.28200402
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.27528606
20ESR1_21235772_ChIP-Seq_MCF-7_Human2.06817830
21RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.00204771
22HIF1A_21447827_ChIP-Seq_MCF-7_Human1.99850522
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.99423883
24BP1_19119308_ChIP-ChIP_Hs578T_Human1.96062169
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.92600637
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.90742468
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.90606890
28* ELK3_25401928_ChIP-Seq_HUVEC_Human1.89554089
29ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.89294250
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74329634
31MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.73590187
32PPAR_26484153_Chip-Seq_NCI-H1993_Human1.65677458
33CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.64073747
34ATF3_27146783_Chip-Seq_COLON_Human1.62722208
35RACK7_27058665_Chip-Seq_MCF-7_Human1.60012573
36STAT3_1855785_ChIP-Seq_MESCs_Mouse1.58977071
37* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.57535480
38* CJUN_26792858_Chip-Seq_BT549_Human1.57279654
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.53596301
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52008007
41EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.50158227
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49139604
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.48888307
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48775632
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.47884953
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43013162
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.42944382
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.42034408
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38938816
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38465811
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.38451634
52ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38034144
53DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36314602
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.35269177
55CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.34976993
56KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34710437
57* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.33748606
58LXR_22292898_ChIP-Seq_THP-1_Human1.33200403
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28697513
60* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.26291695
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24657837
62JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23555457
63ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21957511
64* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21468915
65SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19014304
66SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18998535
67SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18998535
68P63_26484246_Chip-Seq_KERATINOCYTES_Human1.18868065
69PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.17850258
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17717666
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17695836
72TP53_20018659_ChIP-ChIP_R1E_Mouse1.17173610
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.16843547
74P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14064268
75* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13852959
76* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12551517
77SMC1_22415368_ChIP-Seq_MEFs_Mouse1.11372316
78SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09671882
79STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08218946
80ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07661006
81* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06992348
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06023255
83* UBF1/2_26484160_Chip-Seq_HMECs_Human1.05406491
84EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.04795484
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.04403895
86SOX2_20726797_ChIP-Seq_SW620_Human1.04214516
87* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03657558
88NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02709281
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02709281
90SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01192035
91* KDM2B_26808549_Chip-Seq_DND41_Human1.00401590
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00386977
93AR_21909140_ChIP-Seq_LNCAP_Human0.98565089
94SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98331829
95TCF7_22412390_ChIP-Seq_EML_Mouse0.98003617
96SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96386373
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96120221
98KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95800607
99CREB1_26743006_Chip-Seq_LNCaP_Human0.95092735
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94205188
101TET1_21451524_ChIP-Seq_MESCs_Mouse0.93943419
102* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93510090
103EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92696691
104FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.92576094
105SA1_27219007_Chip-Seq_ERYTHROID_Human0.92139934
106TET1_21490601_ChIP-Seq_MESCs_Mouse0.91634839
107WT1_19549856_ChIP-ChIP_CCG9911_Human0.90053563
108CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89134189
109* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89067425
110CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88092217
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87814687
112KDM2B_26808549_Chip-Seq_K562_Human0.87678594
113CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.87501989
114* TP63_22573176_ChIP-Seq_HFKS_Human0.87481036
115* TP53_23651856_ChIP-Seq_MEFs_Mouse0.86438650
116GATA1_19941826_ChIP-Seq_K562_Human0.85799635
117ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85473501
118NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84885365
119BRD4_25478319_ChIP-Seq_HGPS_Human0.84781346
120KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84570071
121ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84144445
122* GATA3_24758297_ChIP-Seq_MCF-7_Human0.84042241
123CTCF_27219007_Chip-Seq_Bcells_Human0.83108058
124FOXA2_19822575_ChIP-Seq_HepG2_Human0.82188070
125TP53_22127205_ChIP-Seq_IMR90_Human0.81946466

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.99736467
2MP0004084_abnormal_cardiac_muscle4.35641689
3MP0003646_muscle_fatigue4.30947390
4MP0000751_myopathy4.06458703
5MP0008438_abnormal_cutaneous_collagen3.24148448
6MP0004036_abnormal_muscle_relaxation3.18423543
7MP0005330_cardiomyopathy3.06818621
8* MP0000749_muscle_degeneration3.00402599
9MP0004215_abnormal_myocardial_fiber2.97332479
10MP0000750_abnormal_muscle_regeneration2.88241207
11MP0005451_abnormal_body_composition2.67352511
12* MP0004087_abnormal_muscle_fiber2.58562487
13MP0003705_abnormal_hypodermis_morpholog2.49933382
14MP0002972_abnormal_cardiac_muscle2.44725500
15MP0005275_abnormal_skin_tensile2.39465553
16MP0008775_abnormal_heart_ventricle2.36746643
17MP0003279_aneurysm2.35891613
18MP0009780_abnormal_chondrocyte_physiolo2.30275636
19MP0002796_impaired_skin_barrier2.17274993
20MP0005385_cardiovascular_system_phenoty2.16533216
21MP0001544_abnormal_cardiovascular_syste2.16533216
22MP0010234_abnormal_vibrissa_follicle2.14951677
23* MP0010630_abnormal_cardiac_muscle2.10567336
24MP0005503_abnormal_tendon_morphology2.10046107
25MP0006138_congestive_heart_failure2.09627814
26MP0005620_abnormal_muscle_contractility2.09389720
27MP0002106_abnormal_muscle_physiology2.07332728
28MP0000579_abnormal_nail_morphology2.01439654
29MP0004130_abnormal_muscle_cell1.98643307
30MP0002269_muscular_atrophy1.97845783
31MP0004484_altered_response_of1.94605539
32MP0003566_abnormal_cell_adhesion1.87129344
33MP0010368_abnormal_lymphatic_system1.86286061
34* MP0000759_abnormal_skeletal_muscle1.83112898
35MP0005369_muscle_phenotype1.81835389
36MP0000747_muscle_weakness1.78206133
37MP0004145_abnormal_muscle_electrophysio1.75725026
38MP0003137_abnormal_impulse_conducting1.73319175
39MP0000467_abnormal_esophagus_morphology1.73126243
40MP0000343_altered_response_to1.71501174
41MP0005670_abnormal_white_adipose1.60091504
42MP0004272_abnormal_basement_membrane1.59244183
43* MP0003828_pulmonary_edema1.56595193
44MP0003453_abnormal_keratinocyte_physiol1.54305613
45MP0005666_abnormal_adipose_tissue1.52295501
46MP0003950_abnormal_plasma_membrane1.46159085
47MP0004233_abnormal_muscle_weight1.41719264
48MP0009840_abnormal_foam_cell1.39079100
49MP0005623_abnormal_meninges_morphology1.38661557
50MP0002108_abnormal_muscle_morphology1.38376048
51MP0005501_abnormal_skin_physiology1.30913126
52MP0001849_ear_inflammation1.30758545
53MP0002127_abnormal_cardiovascular_syste1.30113300
54MP0004185_abnormal_adipocyte_glucose1.29966709
55MP0004085_abnormal_heartbeat1.29183972
56MP0001958_emphysema1.27315217
57MP0004510_myositis1.24282034
58MP0002332_abnormal_exercise_endurance1.22526806
59MP0005165_increased_susceptibility_to1.20499001
60MP0000733_abnormal_muscle_development1.18093003
61MP0000767_abnormal_smooth_muscle1.16076434
62MP0005375_adipose_tissue_phenotype1.15042302
63MP0009053_abnormal_anal_canal1.13711851
64MP0005409_darkened_coat_color1.12811705
65MP0005023_abnormal_wound_healing1.08832741
66MP0000537_abnormal_urethra_morphology1.07901526
67MP0003806_abnormal_nucleotide_metabolis1.06847941
68MP0001879_abnormal_lymphatic_vessel1.06455975
69* MP0003221_abnormal_cardiomyocyte_apopto1.05261000
70MP0006036_abnormal_mitochondrial_physio1.04661603
71* MP0000266_abnormal_heart_morphology1.01918180
72MP0002128_abnormal_blood_circulation1.00886029
73MP0001216_abnormal_epidermal_layer1.00873158
74MP0003567_abnormal_fetal_cardiomyocyte1.00336939
75MP0005083_abnormal_biliary_tract0.99586359
76MP0009250_abnormal_appendicular_skeleto0.98376246
77MP0001299_abnormal_eye_distance/0.96366853
78MP0005076_abnormal_cell_differentiation0.95975454
79MP0002295_abnormal_pulmonary_circulatio0.95783858
80MP0000678_abnormal_parathyroid_gland0.92216289
81MP0006054_spinal_hemorrhage0.91898451
82MP0000534_abnormal_ureter_morphology0.91113577
83MP0009384_cardiac_valve_regurgitation0.85854939
84MP0002098_abnormal_vibrissa_morphology0.84089648
85MP0002060_abnormal_skin_morphology0.83808855
86MP0005508_abnormal_skeleton_morphology0.83803576
87MP0002234_abnormal_pharynx_morphology0.81443395
88MP0005319_abnormal_enzyme/_coenzyme0.81403087
89MP0002877_abnormal_melanocyte_morpholog0.79696251
90MP0008260_abnormal_autophagy0.79549071
91MP0000013_abnormal_adipose_tissue0.78295352
92MP0004264_abnormal_extraembryonic_tissu0.78286678
93MP0002249_abnormal_larynx_morphology0.78142490
94MP0003315_abnormal_perineum_morphology0.77931950
95MP0000003_abnormal_adipose_tissue0.76793015
96MP0003091_abnormal_cell_migration0.76132949
97MP0001243_abnormal_dermal_layer0.76099278
98MP0003191_abnormal_cellular_cholesterol0.74917012
99MP0003195_calcinosis0.73729557
100MP0010771_integument_phenotype0.71909642
101MP0002089_abnormal_postnatal_growth/wei0.71735580
102MP0010352_gastrointestinal_tract_polyps0.71037155
103MP0000230_abnormal_systemic_arterial0.69670811
104MP0005085_abnormal_gallbladder_physiolo0.68703475
105MP0010678_abnormal_skin_adnexa0.68531117
106MP0000249_abnormal_blood_vessel0.68352190
107MP0005257_abnormal_intraocular_pressure0.67923930
108MP0003045_fibrosis0.67357498
109MP0000627_abnormal_mammary_gland0.67142619
110MP0001614_abnormal_blood_vessel0.67022038
111MP0002925_abnormal_cardiovascular_devel0.64566179
112MP0002971_abnormal_brown_adipose0.64540854
113MP0001542_abnormal_bone_strength0.63797437
114MP0002896_abnormal_bone_mineralization0.63663534
115MP0004858_abnormal_nervous_system0.63366279
116MP0005266_abnormal_metabolism0.61019130
117MP0010030_abnormal_orbit_morphology0.59596388
118MP0003252_abnormal_bile_duct0.58929015
119MP0005595_abnormal_vascular_smooth0.54615924
120MP0009115_abnormal_fat_cell0.53918866
121MP0002933_joint_inflammation0.53208502
122MP0000762_abnormal_tongue_morphology0.52357686
123MP0003186_abnormal_redox_activity0.51673343
124MP0003656_abnormal_erythrocyte_physiolo0.50251279
125MP0005390_skeleton_phenotype0.49977217
126MP0005332_abnormal_amino_acid0.48445972
127MP0005058_abnormal_lysosome_morphology0.48268571
128* MP0002118_abnormal_lipid_homeostasis0.47034052
129MP0003941_abnormal_skin_development0.45750341

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber splitting (HP:0003555)5.93912453
2Sudden death (HP:0001699)5.84521945
3Ventricular tachycardia (HP:0004756)5.58265237
4Increased connective tissue (HP:0009025)5.15171801
5Hyporeflexia of lower limbs (HP:0002600)5.09483483
6Right ventricular cardiomyopathy (HP:0011663)4.91367215
7Exercise-induced muscle cramps (HP:0003710)4.89772036
8Calf muscle hypertrophy (HP:0008981)4.71397898
9Exercise-induced myalgia (HP:0003738)4.47113509
10Atrial fibrillation (HP:0005110)4.41085061
11Abnormality of the calf musculature (HP:0001430)4.37248378
12Muscle hypertrophy of the lower extremities (HP:0008968)4.29514458
13* Lipoatrophy (HP:0100578)4.14806840
14Primary atrial arrhythmia (HP:0001692)4.10036767
15Supraventricular tachycardia (HP:0004755)3.92168430
16Supraventricular arrhythmia (HP:0005115)3.89575006
17Myoglobinuria (HP:0002913)3.86534567
18Asymmetric septal hypertrophy (HP:0001670)3.85219726
19Subaortic stenosis (HP:0001682)3.72316743
20Abnormality of the left ventricular outflow tract (HP:0011103)3.72316743
21Difficulty climbing stairs (HP:0003551)3.64029691
22Distal lower limb muscle weakness (HP:0009053)3.59565376
23Difficulty running (HP:0009046)3.55587045
24Bundle branch block (HP:0011710)3.52587417
25Type 1 muscle fiber predominance (HP:0003803)3.50246817
26Palpitations (HP:0001962)3.48724904
27Premature rupture of membranes (HP:0001788)3.48166881
28Myopathic facies (HP:0002058)3.47414108
29Dilated cardiomyopathy (HP:0001644)3.47056923
30* EMG: myopathic abnormalities (HP:0003458)3.46886250
31Centrally nucleated skeletal muscle fibers (HP:0003687)3.43602889
32Protrusio acetabuli (HP:0003179)3.42608042
33Syncope (HP:0001279)3.29449103
34Myotonia (HP:0002486)3.19355860
35Abnormal atrioventricular conduction (HP:0005150)3.12131919
36Rhabdomyolysis (HP:0003201)3.08771803
37Ventricular arrhythmia (HP:0004308)3.00713038
38Broad metatarsal (HP:0001783)2.98558991
39Heart block (HP:0012722)2.98539649
40Atrioventricular block (HP:0001678)2.97819805
41Prolonged QT interval (HP:0001657)2.96798130
42Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.84511901
43Muscle fiber inclusion bodies (HP:0100299)2.82411180
44Increased variability in muscle fiber diameter (HP:0003557)2.82008158
45Ulnar deviation of the wrist (HP:0003049)2.81929958
46Mildly elevated creatine phosphokinase (HP:0008180)2.75244009
47Abnormality of skeletal muscle fiber size (HP:0012084)2.67107752
48Rimmed vacuoles (HP:0003805)2.60567415
49Areflexia of lower limbs (HP:0002522)2.55576538
50Bulbar palsy (HP:0001283)2.48148589
51Distal lower limb amyotrophy (HP:0008944)2.47774641
52Muscle stiffness (HP:0003552)2.47129550
53Hypoglycemic coma (HP:0001325)2.47074762
54Achilles tendon contracture (HP:0001771)2.44566652
55Slender build (HP:0001533)2.43009443
56Limb-girdle muscle atrophy (HP:0003797)2.42228385
57Hypoplastic ischia (HP:0003175)2.38526235
58Alopecia of scalp (HP:0002293)2.35576634
59Ventricular fibrillation (HP:0001663)2.31713125
60Ankle contracture (HP:0006466)2.28699628
61Neck muscle weakness (HP:0000467)2.27145920
62Nuclear cataract (HP:0100018)2.27020761
63Abnormality of the ischium (HP:0003174)2.24471895
64Ketoacidosis (HP:0001993)2.23899167
65Abnormality of the shoulder girdle musculature (HP:0001435)2.20711335
66Testicular atrophy (HP:0000029)2.18808602
67* Generalized amyotrophy (HP:0003700)2.15711909
68Cerebral aneurysm (HP:0004944)2.15076431
69Abnormality of fatty-acid metabolism (HP:0004359)2.13481076
70Abnormality of the Achilles tendon (HP:0005109)2.12694539
71Shoulder girdle muscle weakness (HP:0003547)2.12292850
72Vascular tortuosity (HP:0004948)2.09841387
73Follicular hyperkeratosis (HP:0007502)2.08957232
74Foot dorsiflexor weakness (HP:0009027)2.07590862
75Broad face (HP:0000283)2.06504978
76Round ear (HP:0100830)2.05918931
77Nemaline bodies (HP:0003798)2.05769407
78* Spinal rigidity (HP:0003306)2.05105329
79Scapular winging (HP:0003691)2.03331306
80Facial diplegia (HP:0001349)2.02694986
81Abnormality of the foot musculature (HP:0001436)2.01569412
82Abnormal EKG (HP:0003115)1.99989624
83Short nail (HP:0001799)1.99383927
84Frequent falls (HP:0002359)1.99293340
85Arterial tortuosity (HP:0005116)1.99057012
86Mitral regurgitation (HP:0001653)1.97843473
87Fragile skin (HP:0001030)1.95309092
88Polycythemia (HP:0001901)1.95077562
89* Palmoplantar keratoderma (HP:0000982)1.94466203
90Aortic aneurysm (HP:0004942)1.94290622
91Distal arthrogryposis (HP:0005684)1.92844494
92Pterygium (HP:0001059)1.92502288
93Distal upper limb amyotrophy (HP:0007149)1.92257060
94Upper limb amyotrophy (HP:0009129)1.92257060
95Milia (HP:0001056)1.91526813
96Fragile nails (HP:0001808)1.91407588
97Elbow flexion contracture (HP:0002987)1.90500729
98Pelvic girdle muscle weakness (HP:0003749)1.89077193
99Calcaneovalgus deformity (HP:0001848)1.89026493
100Aneurysm (HP:0002617)1.88963278
101Dicarboxylic aciduria (HP:0003215)1.88260369
102Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88260369
103Abnormality of nail color (HP:0100643)1.88159285
104Shallow orbits (HP:0000586)1.87421548
105Hypoalphalipoproteinemia (HP:0003233)1.87327155
106EMG: neuropathic changes (HP:0003445)1.86360217
107Back pain (HP:0003418)1.85938454
108Malignant hyperthermia (HP:0002047)1.85161334
109Generalized muscle weakness (HP:0003324)1.84908815
110Gowers sign (HP:0003391)1.84109487
111Abnormality of the hip-girdle musculature (HP:0001445)1.83240796
112Abnormality of the musculature of the pelvis (HP:0001469)1.83240796
113Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.83046787
114Sudden cardiac death (HP:0001645)1.82992627
115Popliteal pterygium (HP:0009756)1.82778171
116Abnormality of the umbilical cord (HP:0010881)1.81773633
117Hip contracture (HP:0003273)1.79922290
118Abnormality of the neuromuscular junction (HP:0003398)1.77450962
119Fatigable weakness (HP:0003473)1.77450962
120Cervical subluxation (HP:0003308)1.76807088
121Atrophic scars (HP:0001075)1.75289485
122Ketosis (HP:0001946)1.74656330
123Reduced subcutaneous adipose tissue (HP:0003758)1.74291456
124Hepatic necrosis (HP:0002605)1.73272302
125Pulmonary artery stenosis (HP:0004415)1.73049912
126Lower limb amyotrophy (HP:0007210)1.72613308
127* Muscular dystrophy (HP:0003560)1.71985130
128Left ventricular hypertrophy (HP:0001712)1.71810705
129Nausea (HP:0002018)1.71315013
130Trismus (HP:0000211)1.70529333
131Progressive muscle weakness (HP:0003323)1.69768560
132Ulnar bowing (HP:0003031)1.68810838
133Skin nodule (HP:0200036)1.68801301
134Aortic dissection (HP:0002647)1.66048782
135Vertebral compression fractures (HP:0002953)1.65793497
136Wrist flexion contracture (HP:0001239)1.65258192
137Lymphangioma (HP:0100764)1.64312447
138Hyperglycemia (HP:0003074)1.64043306
139* Congestive heart failure (HP:0001635)1.63506678
140Conjunctival hamartoma (HP:0100780)1.62992863
141Mesangial abnormality (HP:0001966)1.61464611
142Limb-girdle muscle weakness (HP:0003325)1.59946720

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.32383302
2TRIB33.39777999
3LMTK22.89066410
4TSSK62.85966708
5OBSCN2.73660875
6MYLK2.70956606
7PHKG22.66572592
8PHKG12.66572592
9ERN12.45433426
10DMPK2.42337606
11PKN22.30774117
12MAPKAPK52.29364862
13PDK42.28604805
14PDK32.28604805
15IRAK32.22271034
16BCKDK2.18907136
17ARAF2.05592026
18PDK22.05095600
19TESK11.99412187
20TIE11.94512504
21PNCK1.88729581
22LATS21.78940554
23MAP3K31.75273764
24MUSK1.74731224
25PIK3CA1.70129494
26EPHB11.67751473
27RIPK11.59181296
28MAP3K91.47871283
29EPHA31.47452649
30MAPK151.47336133
31MAPKAPK31.45005359
32PINK11.42712640
33PDGFRA1.42606752
34TGFBR21.42024170
35WEE11.38553544
36STK38L1.38367067
37ICK1.34089641
38LATS11.33044053
39SIK11.32145975
40MAP2K31.27982481
41STK241.27192391
42EPHB21.24718139
43FGFR41.23105694
44NEK11.19842559
45FER1.19205905
46TRPM71.18783389
47DDR21.17199463
48PRKD11.16506357
49PAK31.12885042
50PIM21.10658932
51KDR1.03984011
52SMG11.03609516
53TAOK21.02195732
54NEK91.01042862
55MAP3K130.98749776
56ERBB40.98665362
57GRK70.96658476
58MAP3K120.96029135
59ILK0.95899027
60RPS6KB20.94887247
61ROCK10.90787488
62MAP3K110.88871594
63KSR20.88669710
64PIK3CG0.87400451
65EPHA20.87296253
66PTK60.84124854
67NME20.84121015
68CAMK2G0.82863291
69EEF2K0.82301570
70MAP3K50.80743492
71CAMK2D0.80650055
72MAPK120.79129140
73BMX0.75359757
74NTRK10.74148112
75PRPF4B0.74056841
76TBK10.73381057
77BRAF0.71385571
78CDC42BPA0.69059333
79PTK20.68351550
80ZAK0.65341965
81MAP3K70.64335956
82FLT30.64246419
83MAP2K10.63521843
84PRKAA20.63493841
85PRKG20.63000885
86WNK40.61236632
87PTK2B0.61122578
88SCYL20.59672954
89LRRK20.58538221
90PRKD30.58511527
91DAPK30.58162025
92TAOK10.58071631
93MAP2K20.57601484
94RPS6KA60.56402174
95RPS6KL10.55794716
96RPS6KC10.55794716
97PRKAA10.55110699
98SIK30.55081674
99RPS6KA20.54236553
100* MTOR0.53922205
101MET0.51525013
102PAK20.51200288
103WNK10.50108265
104MST1R0.49139232
105JAK10.49005248
106CDK120.48156313
107RAF10.45317455
108PBK0.45017011
109MAP3K10.44327079
110PRKD20.44036690
111MAPKAPK20.43998071
112STK40.43963444
113INSRR0.42050271
114ROCK20.41716277
115STK30.41700997
116PAK40.40434305
117MOS0.40402688
118ABL20.40152365
119CAMK2B0.39617510
120TGFBR10.38117338
121PDPK10.38089107
122LIMK10.38001454
123GSK3A0.37786417
124AKT30.37429644
125CAMK40.37194746
126EIF2AK30.37078131
127KSR10.36139432
128RPS6KA40.36104088
129TYK20.35692065
130PRKCE0.34872068
131PRKCI0.34771207
132MAP3K20.34285318
133PAK10.34006280
134FGFR30.33568490
135NLK0.32425181
136MAP3K80.32369043
137AKT20.31852454
138PDGFRB0.31721812
139STK380.31344578

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.33129207
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.49346575
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.23541315
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.10916947
5Dilated cardiomyopathy_Homo sapiens_hsa054143.10685767
6Fatty acid degradation_Homo sapiens_hsa000712.82595719
7Cardiac muscle contraction_Homo sapiens_hsa042602.74112039
8Propanoate metabolism_Homo sapiens_hsa006402.66986233
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.32676545
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.28452770
11Fatty acid metabolism_Homo sapiens_hsa012122.17145601
12Carbon metabolism_Homo sapiens_hsa012002.04087786
13Parkinsons disease_Homo sapiens_hsa050121.73317378
14PPAR signaling pathway_Homo sapiens_hsa033201.72758328
15Estrogen signaling pathway_Homo sapiens_hsa049151.71490040
16Viral myocarditis_Homo sapiens_hsa054161.70185583
17ECM-receptor interaction_Homo sapiens_hsa045121.68443734
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.66561028
19Oxidative phosphorylation_Homo sapiens_hsa001901.63467636
20Pentose phosphate pathway_Homo sapiens_hsa000301.62725650
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.61645001
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59475177
23Circadian rhythm_Homo sapiens_hsa047101.57113838
24Starch and sucrose metabolism_Homo sapiens_hsa005001.47690286
25Pyruvate metabolism_Homo sapiens_hsa006201.40648193
26Arginine biosynthesis_Homo sapiens_hsa002201.38849977
27Tryptophan metabolism_Homo sapiens_hsa003801.37651528
28Focal adhesion_Homo sapiens_hsa045101.37300613
29Insulin resistance_Homo sapiens_hsa049311.25096908
30Alzheimers disease_Homo sapiens_hsa050101.22440222
31Adipocytokine signaling pathway_Homo sapiens_hsa049201.21927915
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19698037
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16733003
34Fatty acid elongation_Homo sapiens_hsa000621.15268393
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11737765
36Arginine and proline metabolism_Homo sapiens_hsa003301.10650686
37Vibrio cholerae infection_Homo sapiens_hsa051101.08006040
38Thyroid cancer_Homo sapiens_hsa052161.03987107
39Adherens junction_Homo sapiens_hsa045201.02977419
40Hippo signaling pathway_Homo sapiens_hsa043901.02701261
41Notch signaling pathway_Homo sapiens_hsa043301.01954172
42Amoebiasis_Homo sapiens_hsa051461.00923762
43VEGF signaling pathway_Homo sapiens_hsa043700.99807901
44Phenylalanine metabolism_Homo sapiens_hsa003600.97348788
45Galactose metabolism_Homo sapiens_hsa000520.95927996
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95732306
47Biosynthesis of amino acids_Homo sapiens_hsa012300.94997425
48Huntingtons disease_Homo sapiens_hsa050160.93368873
49Butanoate metabolism_Homo sapiens_hsa006500.92016628
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87627101
51Renal cell carcinoma_Homo sapiens_hsa052110.85761922
52beta-Alanine metabolism_Homo sapiens_hsa004100.83559752
53ErbB signaling pathway_Homo sapiens_hsa040120.82732606
54Endocytosis_Homo sapiens_hsa041440.82268196
55Proteoglycans in cancer_Homo sapiens_hsa052050.81613986
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80898739
57GnRH signaling pathway_Homo sapiens_hsa049120.80588011
58HIF-1 signaling pathway_Homo sapiens_hsa040660.80145080
59Insulin signaling pathway_Homo sapiens_hsa049100.79748339
60Melanogenesis_Homo sapiens_hsa049160.79421460
61Complement and coagulation cascades_Homo sapiens_hsa046100.79094354
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77506051
63MAPK signaling pathway_Homo sapiens_hsa040100.77466963
64Chronic myeloid leukemia_Homo sapiens_hsa052200.77072269
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77065082
66Other glycan degradation_Homo sapiens_hsa005110.75881681
67Fat digestion and absorption_Homo sapiens_hsa049750.75133629
68Endometrial cancer_Homo sapiens_hsa052130.74697558
69Peroxisome_Homo sapiens_hsa041460.73023190
70Lysine degradation_Homo sapiens_hsa003100.72656257
71Malaria_Homo sapiens_hsa051440.70391138
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70297444
73Glucagon signaling pathway_Homo sapiens_hsa049220.69901740
74Oxytocin signaling pathway_Homo sapiens_hsa049210.69105685
75AMPK signaling pathway_Homo sapiens_hsa041520.67305143
76Tyrosine metabolism_Homo sapiens_hsa003500.66393940
77Caffeine metabolism_Homo sapiens_hsa002320.66025643
78Tight junction_Homo sapiens_hsa045300.66021442
79Glioma_Homo sapiens_hsa052140.65681205
80Protein digestion and absorption_Homo sapiens_hsa049740.65119277
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64493887
82Prostate cancer_Homo sapiens_hsa052150.64083336
83Folate biosynthesis_Homo sapiens_hsa007900.63814809
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61889569
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60859688
86Toxoplasmosis_Homo sapiens_hsa051450.60608142
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.59690886
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.59449659
89Fructose and mannose metabolism_Homo sapiens_hsa000510.59148666
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59049430
91Axon guidance_Homo sapiens_hsa043600.58203396
92Basal cell carcinoma_Homo sapiens_hsa052170.57469670
93Nitrogen metabolism_Homo sapiens_hsa009100.56835663
94Fatty acid biosynthesis_Homo sapiens_hsa000610.56198402
95Wnt signaling pathway_Homo sapiens_hsa043100.55840808
96mTOR signaling pathway_Homo sapiens_hsa041500.53492948
97FoxO signaling pathway_Homo sapiens_hsa040680.53376010
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53216699
99Bile secretion_Homo sapiens_hsa049760.52582628
100Sulfur metabolism_Homo sapiens_hsa009200.51852797
101Calcium signaling pathway_Homo sapiens_hsa040200.51003637
102Small cell lung cancer_Homo sapiens_hsa052220.49083885
103Bladder cancer_Homo sapiens_hsa052190.49030388
104MicroRNAs in cancer_Homo sapiens_hsa052060.48860070
105Pathways in cancer_Homo sapiens_hsa052000.47550368
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.46408761
107Legionellosis_Homo sapiens_hsa051340.46264061
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45705822
109Chemical carcinogenesis_Homo sapiens_hsa052040.44944542
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44358016
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44180116
112Staphylococcus aureus infection_Homo sapiens_hsa051500.44156873
113Melanoma_Homo sapiens_hsa052180.44023915
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43767277
115Acute myeloid leukemia_Homo sapiens_hsa052210.43622757
116Sphingolipid metabolism_Homo sapiens_hsa006000.43511073
117Pancreatic cancer_Homo sapiens_hsa052120.43346489
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43021894
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.42952721
120Prion diseases_Homo sapiens_hsa050200.42470795
121Hedgehog signaling pathway_Homo sapiens_hsa043400.42211888
122Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41617543
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39615018
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38898140
125Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38759330
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37309609
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37303926
128Glutathione metabolism_Homo sapiens_hsa004800.32974227
129TGF-beta signaling pathway_Homo sapiens_hsa043500.32713099
130Salmonella infection_Homo sapiens_hsa051320.32605678
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32523114
132Glycerolipid metabolism_Homo sapiens_hsa005610.31412807
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.31128312
134Dorso-ventral axis formation_Homo sapiens_hsa043200.30406896
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30222387
136Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29354238
137Lysosome_Homo sapiens_hsa041420.26019998
138Sulfur relay system_Homo sapiens_hsa041220.25075543
139TNF signaling pathway_Homo sapiens_hsa046680.24708315
140Glycosaminoglycan degradation_Homo sapiens_hsa005310.23896027
141Leishmaniasis_Homo sapiens_hsa051400.23768317

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