B4GALT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene encodes an enzyme that may be mainly involved in the synthesis of the first N-acetyllactosamine unit of poly-N-acetyllactosamine chains. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.05376538
2ribosomal small subunit assembly (GO:0000028)5.85285195
3Golgi transport vesicle coating (GO:0048200)4.91722653
4COPI coating of Golgi vesicle (GO:0048205)4.91722653
5protein maturation by protein folding (GO:0022417)4.59694057
6respiratory chain complex IV assembly (GO:0008535)4.58086985
7facial nerve structural organization (GO:0021612)4.55429527
8viral transcription (GO:0019083)4.40531068
9proteasome assembly (GO:0043248)4.23802368
10translational termination (GO:0006415)4.18670313
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.15005284
12protoporphyrinogen IX metabolic process (GO:0046501)4.14215909
13gonadal mesoderm development (GO:0007506)4.10070749
14cotranslational protein targeting to membrane (GO:0006613)4.03203765
15protein targeting to ER (GO:0045047)4.00317471
16telomere maintenance via semi-conservative replication (GO:0032201)3.99443978
17lymphoid progenitor cell differentiation (GO:0002320)3.98061889
18proline biosynthetic process (GO:0006561)3.94413048
19cytochrome complex assembly (GO:0017004)3.89062463
20protein localization to endoplasmic reticulum (GO:0070972)3.82072568
21deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.80738593
22establishment of protein localization to endoplasmic reticulum (GO:0072599)3.76808159
23negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.75472608
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.67855956
25platelet dense granule organization (GO:0060155)3.67853194
26ribosomal small subunit biogenesis (GO:0042274)3.65655887
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.64876948
28response to interferon-beta (GO:0035456)3.63854821
29DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.63037241
30immunoglobulin mediated immune response (GO:0016064)3.57272362
31intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.55469615
32signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.55469615
33maturation of SSU-rRNA (GO:0030490)3.55278367
34protoporphyrinogen IX biosynthetic process (GO:0006782)3.51644318
35translational elongation (GO:0006414)3.50367827
36signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.49787921
37signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.49787921
38signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.49787921
39signal transduction involved in DNA damage checkpoint (GO:0072422)3.47441018
40signal transduction involved in DNA integrity checkpoint (GO:0072401)3.47441018
41positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.47013176
42mannosylation (GO:0097502)3.44853389
43negative regulation of B cell apoptotic process (GO:0002903)3.42830702
44signal transduction involved in cell cycle checkpoint (GO:0072395)3.42118903
45negative regulation of transcription by competitive promoter binding (GO:0010944)3.36703050
46GDP-mannose metabolic process (GO:0019673)3.36346524
47negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.35892878
48negative regulation of ligase activity (GO:0051352)3.35892878
49regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.34474033
50anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.32902820
51negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.32276723
52negative regulation of T-helper cell differentiation (GO:0045623)3.32276723
53dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.31267546
54amino sugar catabolic process (GO:0046348)3.30975924
55telomere maintenance via recombination (GO:0000722)3.30389560
56viral life cycle (GO:0019058)3.29704097
57regulation of cellular amino acid metabolic process (GO:0006521)3.28568061
58GMP metabolic process (GO:0046037)3.25168402
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.25050405
60negative regulation of erythrocyte differentiation (GO:0045647)3.22665217
61mature B cell differentiation involved in immune response (GO:0002313)3.20981092
62positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.20809708
63formation of translation preinitiation complex (GO:0001731)3.20502066
64protein targeting to mitochondrion (GO:0006626)3.19490824
65negative regulation of myotube differentiation (GO:0010832)3.09408753
66positive regulation of ligase activity (GO:0051351)3.08559050
67cullin deneddylation (GO:0010388)3.07662111
68cellular protein complex disassembly (GO:0043624)3.06071926
69postsynaptic membrane organization (GO:0001941)3.04787835
70antigen processing and presentation via MHC class Ib (GO:0002475)3.04511748
71DNA strand elongation involved in DNA replication (GO:0006271)3.03210760
72endosome to melanosome transport (GO:0035646)3.02428791
73endosome to pigment granule transport (GO:0043485)3.02428791
74nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02428568
75tRNA methylation (GO:0030488)3.01377424
76antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.99699820
77regulation of translational fidelity (GO:0006450)2.99434625
78mitochondrial fusion (GO:0008053)2.98294307
79N-acetylneuraminate metabolic process (GO:0006054)2.97577249
80cranial nerve structural organization (GO:0021604)2.97353115
81heme biosynthetic process (GO:0006783)2.96665751
82modulation by virus of host process (GO:0019054)2.95659058
83DNA strand elongation (GO:0022616)2.95437132
84DNA replication initiation (GO:0006270)2.94624295
85protein deneddylation (GO:0000338)2.93909554
86ribosome biogenesis (GO:0042254)2.93711982
87establishment of protein localization to mitochondrion (GO:0072655)2.93541624
88translational initiation (GO:0006413)2.92924378
89positive regulation of cell cycle arrest (GO:0071158)2.92592315
90transcription elongation from RNA polymerase III promoter (GO:0006385)2.92009393
91termination of RNA polymerase III transcription (GO:0006386)2.92009393
92nuclear envelope reassembly (GO:0031468)2.91176043
93mitotic nuclear envelope reassembly (GO:0007084)2.91176043
94membrane invagination (GO:0010324)2.90928120
95negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.89859369
96C-terminal protein lipidation (GO:0006501)2.89823220
97cranial nerve morphogenesis (GO:0021602)2.87925364
98defense response to protozoan (GO:0042832)2.87576663
99iron-sulfur cluster assembly (GO:0016226)2.86479128
100metallo-sulfur cluster assembly (GO:0031163)2.86479128
101protein localization to mitochondrion (GO:0070585)2.86359760
102B cell mediated immunity (GO:0019724)2.86096103
103chaperone mediated protein folding requiring cofactor (GO:0051085)2.85547091
104pseudouridine synthesis (GO:0001522)2.85344274
105mature B cell differentiation (GO:0002335)2.84774181
106rRNA modification (GO:0000154)2.84065188
107tRNA aminoacylation (GO:0043039)2.83439992
108amino acid activation (GO:0043038)2.83439992
109tRNA aminoacylation for protein translation (GO:0006418)2.83175905
110regulation of ubiquitin-protein transferase activity (GO:0051438)2.82876877
111GPI anchor biosynthetic process (GO:0006506)2.82286588
112porphyrin-containing compound biosynthetic process (GO:0006779)2.78871389
113regulation of translation in response to stress (GO:0043555)2.78239033
114spliceosomal tri-snRNP complex assembly (GO:0000244)2.77944015
115response to interferon-alpha (GO:0035455)2.77502164
116regulation of chromatin binding (GO:0035561)2.75420642
117regulation of ligase activity (GO:0051340)2.74230655
118regulation of T cell receptor signaling pathway (GO:0050856)2.73729314
119cellular response to interferon-beta (GO:0035458)2.73431343
120ribosome assembly (GO:0042255)2.72428562
121phospholipid scrambling (GO:0017121)2.72048227
122DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.70310076
123ribosomal large subunit biogenesis (GO:0042273)2.70048122
124mitotic recombination (GO:0006312)2.69764503
125mast cell activation (GO:0045576)2.69548531
126ribonucleoprotein complex biogenesis (GO:0022613)2.69345234
127telomere maintenance via telomere lengthening (GO:0010833)2.69031119
128negative regulation of protein ubiquitination (GO:0031397)2.67908248
129translation (GO:0006412)2.67747865
130protein complex disassembly (GO:0043241)2.66562156
131negative regulation of type 2 immune response (GO:0002829)2.66022327
132CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.64643979
133response to protozoan (GO:0001562)2.64074501
134peptidyl-arginine omega-N-methylation (GO:0035247)2.61836118
135mitotic metaphase plate congression (GO:0007080)2.61462818
136positive regulation of T cell mediated cytotoxicity (GO:0001916)2.60517378
137maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.60327234
138NIK/NF-kappaB signaling (GO:0038061)2.60091318
139regulation of cell cycle arrest (GO:0071156)2.59867612
140positive regulation of protein homooligomerization (GO:0032464)2.59808847
141response to peptidoglycan (GO:0032494)2.59301965
142regulation of pigment cell differentiation (GO:0050932)2.58399177
143tetrapyrrole biosynthetic process (GO:0033014)2.58095108
144regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.56599240
145definitive hemopoiesis (GO:0060216)2.56369163
146negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.55640954
147negative regulation of DNA-templated transcription, elongation (GO:0032785)2.54760444
148activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.54331486
149regulation of mitochondrial translation (GO:0070129)2.54287130
150positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.53833687
151retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.52856637
152macromolecular complex disassembly (GO:0032984)2.51389201
153detection of bacterium (GO:0016045)2.51185270
154viral protein processing (GO:0019082)2.50785903
155signal peptide processing (GO:0006465)2.50305090
156antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.49932029
157chaperone-mediated protein transport (GO:0072321)2.49752737
158pentose metabolic process (GO:0019321)2.49615507
159exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.49509863
160signal transduction in response to DNA damage (GO:0042770)2.49072297
161positive regulation of B cell differentiation (GO:0045579)2.48625713
162mitotic chromosome condensation (GO:0007076)2.47862606
163protein retention in ER lumen (GO:0006621)2.47841921
164proline metabolic process (GO:0006560)2.46916349
165peptidyl-histidine modification (GO:0018202)2.46595194
166fucose catabolic process (GO:0019317)2.45439533
167L-fucose metabolic process (GO:0042354)2.45439533
168L-fucose catabolic process (GO:0042355)2.45439533
169regulation of RIG-I signaling pathway (GO:0039535)2.45308426
170snRNA metabolic process (GO:0016073)2.45291827
171negative regulation of metanephros development (GO:0072217)2.44202508
172positive regulation of granulocyte differentiation (GO:0030854)2.43758211
173DNA damage response, detection of DNA damage (GO:0042769)2.43607312
174regulation of B cell apoptotic process (GO:0002902)2.43284193
175negative regulation of B cell mediated immunity (GO:0002713)2.43157714
176negative regulation of immunoglobulin mediated immune response (GO:0002890)2.43157714
177protein targeting to membrane (GO:0006612)2.42782796
178C-terminal protein amino acid modification (GO:0018410)2.42466536
179de novo posttranslational protein folding (GO:0051084)2.42162484
180de novo protein folding (GO:0006458)2.41310398
181viral mRNA export from host cell nucleus (GO:0046784)2.40778219
182regulation of cellular amine metabolic process (GO:0033238)2.40605972
183negative regulation of alpha-beta T cell differentiation (GO:0046639)2.40325143
184positive regulation of nuclease activity (GO:0032075)2.39303889
185spliceosomal snRNP assembly (GO:0000387)2.38631495
186protein insertion into membrane (GO:0051205)2.38479132
187activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.38018934
188heme metabolic process (GO:0042168)2.37848044
189virion assembly (GO:0019068)2.37701917

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.86749388
2ELF1_17652178_ChIP-ChIP_JURKAT_Human3.49018061
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.26412816
4SCL_19346495_ChIP-Seq_HPC-7_Human3.13624364
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.04966913
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.04833658
7FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.99248005
8SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.93746049
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.90949746
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.90174720
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.89767273
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.89266082
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.80798174
14E2F7_22180533_ChIP-Seq_HELA_Human2.78554394
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.72653729
16LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.72380672
17EZH2_22144423_ChIP-Seq_EOC_Human2.69426297
18* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.60617214
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.50927730
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.43156321
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41536853
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.37180030
23* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.34448307
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.32193172
25* ERG_20887958_ChIP-Seq_HPC-7_Mouse2.29448469
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.26295880
27ETS1_20019798_ChIP-Seq_JURKAT_Human2.25387385
28* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19666338
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17947113
30* VDR_23849224_ChIP-Seq_CD4+_Human2.17569243
31SRF_21415370_ChIP-Seq_HL-1_Mouse2.14087296
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.07645477
33SPI1_23547873_ChIP-Seq_NB4_Human2.06301170
34* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.04705633
35BP1_19119308_ChIP-ChIP_Hs578T_Human2.04030361
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.99059555
37CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.95228741
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.92687788
39LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.92553912
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91394434
41FOXP3_21729870_ChIP-Seq_TREG_Human1.84905916
42KDM5A_27292631_Chip-Seq_BREAST_Human1.82859364
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.82054744
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.80210074
45* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.76615097
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76086998
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.76012971
48MYB_21317192_ChIP-Seq_ERMYB_Mouse1.73951992
49IRF8_21731497_ChIP-ChIP_J774_Mouse1.72255486
50* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.68530367
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66191020
52CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.65478172
53TFEB_21752829_ChIP-Seq_HELA_Human1.62733370
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61905949
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.61477892
56* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.60992624
57* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.56740482
58* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53067218
59FOXM1_23109430_ChIP-Seq_U2OS_Human1.53020610
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51070401
61IGF1R_20145208_ChIP-Seq_DFB_Human1.50448165
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44825439
63VDR_21846776_ChIP-Seq_THP-1_Human1.42864558
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.42846266
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.42042862
66* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.41859321
67GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.41763056
68VDR_24763502_ChIP-Seq_THP-1_Human1.41189461
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.39961954
70* MAF_26560356_Chip-Seq_TH2_Human1.36686018
71GATA1_22025678_ChIP-Seq_K562_Human1.35355583
72* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32923194
73ELK1_19687146_ChIP-ChIP_HELA_Human1.32407684
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32284630
75* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.31545666
76GABP_19822575_ChIP-Seq_HepG2_Human1.31355459
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30406744
78TTF2_22483619_ChIP-Seq_HELA_Human1.30068366
79E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29811990
80* XRN2_22483619_ChIP-Seq_HELA_Human1.29335287
81DCP1A_22483619_ChIP-Seq_HELA_Human1.27304129
82* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27156723
83MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25365694
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22692843
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22301050
86UTX_26944678_Chip-Seq_JUKART_Human1.21769607
87IRF1_19129219_ChIP-ChIP_H3396_Human1.20424126
88DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19464313
89TP63_19390658_ChIP-ChIP_HaCaT_Human1.18318241
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18004430
91* NCOR1_26117541_ChIP-Seq_K562_Human1.16848192
92RUNX1_22412390_ChIP-Seq_EML_Mouse1.16471564
93* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16071816
94KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14984427
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14441292
96* MYB_26560356_Chip-Seq_TH2_Human1.14210275
97MYC_22102868_ChIP-Seq_BL_Human1.12730143
98TET1_21451524_ChIP-Seq_MESCs_Mouse1.12643636
99MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10936483
100STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.10757096
101PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10526615
102STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07925686
103* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07619473
104MAF_26560356_Chip-Seq_TH1_Human1.07300429
105ZNF263_19887448_ChIP-Seq_K562_Human1.07297582
106ELF1_20517297_ChIP-Seq_JURKAT_Human1.07275266
107* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05809295
108RACK7_27058665_Chip-Seq_MCF-7_Human1.05388135
109LXR_22292898_ChIP-Seq_THP-1_Human1.04489937
110TBX5_21415370_ChIP-Seq_HL-1_Mouse1.04085881
111SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03639986
112* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02848489
113EGR1_19374776_ChIP-ChIP_THP-1_Human1.01934216
114SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01664745
115* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01206853
116E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01167472
117IRF8_27001747_Chip-Seq_BMDM_Mouse1.01099603
118EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00928933
119E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00868183
120* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00753403
121* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99890278
122TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98718557
123GATA1_19941827_ChIP-Seq_MEL_Mouse0.97917426
124PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97775911
125E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97203043
126* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96950111
127ELK1_22589737_ChIP-Seq_MCF10A_Human0.96764694
128CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96700610
129* CIITA_25753668_ChIP-Seq_RAJI_Human0.96470033
130MYB_26560356_Chip-Seq_TH1_Human0.95111337
131CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95005157
132* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94194359
133GATA3_21867929_ChIP-Seq_CD8_Mouse0.91736257
134MYC_18940864_ChIP-ChIP_HL60_Human0.89597732
135SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89021102
136FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87951421
137SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87140913
138PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86849126
139YY1_22570637_ChIP-Seq_MALME-3M_Human0.86532217
140* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.86285916
141NANOG_18555785_ChIP-Seq_MESCs_Mouse0.84892553

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.82091014
2MP0005174_abnormal_tail_pigmentation3.57179797
3MP0005409_darkened_coat_color3.42451057
4MP0001188_hyperpigmentation3.35510253
5MP0006292_abnormal_olfactory_placode3.32628472
6MP0000015_abnormal_ear_pigmentation3.16240154
7MP0003111_abnormal_nucleus_morphology3.03832984
8MP0003136_yellow_coat_color2.87490871
9MP0001986_abnormal_taste_sensitivity2.82770346
10MP0005451_abnormal_body_composition2.81591333
11MP0005075_abnormal_melanosome_morpholog2.79663685
12MP0001835_abnormal_antigen_presentation2.65816673
13MP0009785_altered_susceptibility_to2.61573052
14MP0005058_abnormal_lysosome_morphology2.60172989
15MP0003724_increased_susceptibility_to2.56485940
16MP0008260_abnormal_autophagy2.51857383
17MP0005671_abnormal_response_to2.50947788
18MP0004957_abnormal_blastocyst_morpholog2.41896241
19MP0000685_abnormal_immune_system2.30048247
20MP0005083_abnormal_biliary_tract2.19720070
21MP0002396_abnormal_hematopoietic_system2.18817661
22MP0002095_abnormal_skin_pigmentation2.17186444
23MP0000372_irregular_coat_pigmentation2.16398184
24MP0002876_abnormal_thyroid_physiology2.12803442
25MP0003763_abnormal_thymus_physiology2.07096148
26MP0005025_abnormal_response_to2.03778640
27MP0002148_abnormal_hypersensitivity_rea2.03005866
28MP0004381_abnormal_hair_follicle1.98245430
29MP0000681_abnormal_thyroid_gland1.96186125
30MP0001853_heart_inflammation1.93083415
31MP0000490_abnormal_crypts_of1.86132970
32MP0001730_embryonic_growth_arrest1.84188820
33MP0009840_abnormal_foam_cell1.83053329
34MP0006035_abnormal_mitochondrial_morpho1.82013581
35MP0000465_gastrointestinal_hemorrhage1.78619303
36MP0003436_decreased_susceptibility_to1.78592654
37MP0003806_abnormal_nucleotide_metabolis1.78037447
38MP0003693_abnormal_embryo_hatching1.76188799
39MP0009333_abnormal_splenocyte_physiolog1.76149754
40MP0005000_abnormal_immune_tolerance1.75781717
41MP0001661_extended_life_span1.66393705
42MP0002420_abnormal_adaptive_immunity1.65705849
43MP0008058_abnormal_DNA_repair1.64119629
44MP0001819_abnormal_immune_cell1.63767964
45MP0002723_abnormal_immune_serum1.63321762
46MP0001800_abnormal_humoral_immune1.61066942
47MP0002419_abnormal_innate_immunity1.60245690
48MP0008932_abnormal_embryonic_tissue1.59748240
49MP0005397_hematopoietic_system_phenotyp1.55972754
50MP0001545_abnormal_hematopoietic_system1.55972754
51MP0000313_abnormal_cell_death1.55763729
52MP0002452_abnormal_antigen_presenting1.55313629
53MP0002398_abnormal_bone_marrow1.55261091
54MP0002132_abnormal_respiratory_system1.48198265
55MP0005501_abnormal_skin_physiology1.46801949
56MP0003186_abnormal_redox_activity1.46634301
57MP0006036_abnormal_mitochondrial_physio1.46538217
58MP0000358_abnormal_cell_content/1.44661136
59MP0005464_abnormal_platelet_physiology1.43987177
60MP0003866_abnormal_defecation1.40915162
61MP0004264_abnormal_extraembryonic_tissu1.40495512
62MP0000678_abnormal_parathyroid_gland1.36387763
63MP0000716_abnormal_immune_system1.35215605
64MP0002822_catalepsy1.34369701
65MP0000689_abnormal_spleen_morphology1.33553577
66MP0004808_abnormal_hematopoietic_stem1.33428669
67MP0000350_abnormal_cell_proliferation1.31387857
68MP0005387_immune_system_phenotype1.30462792
69MP0001790_abnormal_immune_system1.30462792
70MP0003943_abnormal_hepatobiliary_system1.26614849
71MP0002080_prenatal_lethality1.26324965
72MP0008007_abnormal_cellular_replicative1.24880982
73MP0001727_abnormal_embryo_implantation1.23724501
74MP0005408_hypopigmentation1.22129989
75MP0002722_abnormal_immune_system1.21874336
76MP0002751_abnormal_autonomic_nervous1.20480908
77MP0002429_abnormal_blood_cell1.19695195
78MP0003786_premature_aging1.18493487
79MP0003172_abnormal_lysosome_physiology1.18193365
80MP0003221_abnormal_cardiomyocyte_apopto1.16977355
81MP0010155_abnormal_intestine_physiology1.13649940
82MP0002638_abnormal_pupillary_reflex1.12379007
83MP0002166_altered_tumor_susceptibility1.12094221
84MP0004147_increased_porphyrin_level1.10523432
85MP0001873_stomach_inflammation1.09198007
86MP0003880_abnormal_central_pattern1.08177865
87MP0002405_respiratory_system_inflammati1.08108316
88MP0001697_abnormal_embryo_size1.07534414
89MP0002177_abnormal_outer_ear1.07439629
90MP0005310_abnormal_salivary_gland1.04651588
91MP0003879_abnormal_hair_cell1.03342031
92MP0008995_early_reproductive_senescence1.03120494
93MP0002877_abnormal_melanocyte_morpholog1.02892452
94MP0001672_abnormal_embryogenesis/_devel1.02692456
95MP0005380_embryogenesis_phenotype1.02692456
96MP0003646_muscle_fatigue1.02605532
97MP0003303_peritoneal_inflammation1.01278689
98MP0005379_endocrine/exocrine_gland_phen0.97725367
99MP0005084_abnormal_gallbladder_morpholo0.97639644
100MP0001845_abnormal_inflammatory_respons0.97601299
101MP0005220_abnormal_exocrine_pancreas0.96878255
102MP0009931_abnormal_skin_appearance0.91050959
103MP0002086_abnormal_extraembryonic_tissu0.90516916
104MP0003984_embryonic_growth_retardation0.90444513
105MP0008469_abnormal_protein_level0.90206549
106MP0002938_white_spotting0.89611591
107MP0002006_tumorigenesis0.89536317
108MP0005384_cellular_phenotype0.89271647
109MP0000049_abnormal_middle_ear0.89055969
110MP0002088_abnormal_embryonic_growth/wei0.87757458
111MP0000703_abnormal_thymus_morphology0.86471612
112MP0001764_abnormal_homeostasis0.85399624
113MP0000631_abnormal_neuroendocrine_gland0.84926719
114MP0003183_abnormal_peptide_metabolism0.84712796
115MP0000598_abnormal_liver_morphology0.84338973
116MP0003315_abnormal_perineum_morphology0.84088358
117MP0002009_preneoplasia0.82669096
118MP0002653_abnormal_ependyma_morphology0.82470834
119MP0002277_abnormal_respiratory_mucosa0.82454884
120MP0001919_abnormal_reproductive_system0.82414538
121MP0010094_abnormal_chromosome_stability0.82226687
122MP0002075_abnormal_coat/hair_pigmentati0.81239594
123MP0002693_abnormal_pancreas_physiology0.80549990
124MP0005621_abnormal_cell_physiology0.79874730
125MP0005171_absent_coat_pigmentation0.79656180
126MP0009278_abnormal_bone_marrow0.79371762
127MP0002796_impaired_skin_barrier0.78122228
128MP0004233_abnormal_muscle_weight0.77238079
129MP0001663_abnormal_digestive_system0.75618585
130MP0002210_abnormal_sex_determination0.75017223
131MP0001533_abnormal_skeleton_physiology0.73651609
132MP0001186_pigmentation_phenotype0.71195371
133MP0002163_abnormal_gland_morphology0.70966207
134MP0002102_abnormal_ear_morphology0.70372488
135MP0003718_maternal_effect0.69645149
136MP0000613_abnormal_salivary_gland0.69467484
137MP0002160_abnormal_reproductive_system0.69459267
138MP0005646_abnormal_pituitary_gland0.68543796
139MP0000858_altered_metastatic_potential0.66397236
140MP0000371_diluted_coat_color0.65295933
141MP0002019_abnormal_tumor_incidence0.64542891
142MP0003656_abnormal_erythrocyte_physiolo0.60923642
143MP0009764_decreased_sensitivity_to0.58432777
144MP0004782_abnormal_surfactant_physiolog0.57259677
145MP0001348_abnormal_lacrimal_gland0.57213317
146MP0003938_abnormal_ear_development0.56379111
147MP0003077_abnormal_cell_cycle0.56199846

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)6.74241566
2Reduced antithrombin III activity (HP:0001976)6.14043170
3Abnormal isoelectric focusing of serum transferrin (HP:0003160)4.83516209
4Abnormal protein N-linked glycosylation (HP:0012347)4.83516209
5Abnormal protein glycosylation (HP:0012346)4.83516209
6Abnormal glycosylation (HP:0012345)4.83516209
7Aplastic anemia (HP:0001915)4.30137443
8Cholecystitis (HP:0001082)4.30104939
9Abnormal gallbladder physiology (HP:0012438)4.30104939
10Abnormal number of erythroid precursors (HP:0012131)4.24517237
11Abnormality of cells of the erythroid lineage (HP:0012130)4.21322917
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.81035424
13Nonprogressive disorder (HP:0003680)3.68381782
14Elevated erythrocyte sedimentation rate (HP:0003565)3.61733245
15Severe visual impairment (HP:0001141)3.42707823
16Hypothermia (HP:0002045)3.39397930
17Thyroid-stimulating hormone excess (HP:0002925)3.34443169
18Type 2 muscle fiber atrophy (HP:0003554)3.33611427
19Reticulocytopenia (HP:0001896)3.31335696
20Cerebral hypomyelination (HP:0006808)3.19271601
21Thrombocytosis (HP:0001894)3.13258378
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.04995182
23Rough bone trabeculation (HP:0100670)3.03425546
24Muscle fiber atrophy (HP:0100295)3.02703506
25Cholelithiasis (HP:0001081)2.97859894
26Dry hair (HP:0011359)2.96761863
27Increased hepatocellular lipid droplets (HP:0006565)2.90486018
28Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.89463058
29Abnormal mitochondria in muscle tissue (HP:0008316)2.89434661
30Renal Fanconi syndrome (HP:0001994)2.83917118
31Abnormality of the columella (HP:0009929)2.80584484
32Myositis (HP:0100614)2.79198469
33Hypertensive crisis (HP:0100735)2.76040826
34Recurrent abscess formation (HP:0002722)2.72481962
35Reticulocytosis (HP:0001923)2.69913957
36Exertional dyspnea (HP:0002875)2.69708114
37Mediastinal lymphadenopathy (HP:0100721)2.63831156
38Abnormal rod and cone electroretinograms (HP:0008323)2.63490324
39Petechiae (HP:0000967)2.62542200
40True hermaphroditism (HP:0010459)2.62063270
41Hepatocellular necrosis (HP:0001404)2.61037996
42Abnormal gallbladder morphology (HP:0012437)2.58696537
43Abnormality of the heme biosynthetic pathway (HP:0010472)2.56230278
44IgM deficiency (HP:0002850)2.55792729
45Acute necrotizing encephalopathy (HP:0006965)2.54901840
46Meningitis (HP:0001287)2.53794844
47Pustule (HP:0200039)2.53378057
48Testicular atrophy (HP:0000029)2.52246572
493-Methylglutaconic aciduria (HP:0003535)2.51600612
50Upper limb muscle weakness (HP:0003484)2.42000090
51Abnormality of magnesium homeostasis (HP:0004921)2.40309909
52Trismus (HP:0000211)2.38185958
53Acute encephalopathy (HP:0006846)2.37886268
54Lipid accumulation in hepatocytes (HP:0006561)2.37546592
55Attenuation of retinal blood vessels (HP:0007843)2.36814194
56Chronic obstructive pulmonary disease (HP:0006510)2.36670295
57Obstructive lung disease (HP:0006536)2.36670295
58Pallor (HP:0000980)2.35942997
59Nonimmune hydrops fetalis (HP:0001790)2.35218463
60Thoracic kyphosis (HP:0002942)2.32027187
61Seborrheic dermatitis (HP:0001051)2.31937145
62Abnormal trabecular bone morphology (HP:0100671)2.31310488
63Broad face (HP:0000283)2.30734644
64Prolonged bleeding time (HP:0003010)2.26855821
65Abnormality of lateral ventricle (HP:0030047)2.25621946
66Macrocytic anemia (HP:0001972)2.25248034
67Cortical visual impairment (HP:0100704)2.24897761
68Microvesicular hepatic steatosis (HP:0001414)2.24411818
69Chronic otitis media (HP:0000389)2.23029650
70Ragged-red muscle fibers (HP:0003200)2.22355188
71Abnormality of the gallbladder (HP:0005264)2.21228840
72Abnormality of reticulocytes (HP:0004312)2.19892318
73Abnormality of the prostate (HP:0008775)2.18790957
74Microcytic anemia (HP:0001935)2.17805214
75Recurrent viral infections (HP:0004429)2.17351997
76Cutaneous melanoma (HP:0012056)2.16679954
77Premature ovarian failure (HP:0008209)2.15974767
78Vertebral compression fractures (HP:0002953)2.15456904
79Abnormality of T cell physiology (HP:0011840)2.15290152
80Recurrent bacterial skin infections (HP:0005406)2.15269200
81Opisthotonus (HP:0002179)2.14986982
82Increased serum lactate (HP:0002151)2.14846052
83Abnormality of small intestinal villus morphology (HP:0011472)2.14771288
84Villous atrophy (HP:0011473)2.14771288
85Increased CSF lactate (HP:0002490)2.14586699
86Hepatic necrosis (HP:0002605)2.14328664
87Pancytopenia (HP:0001876)2.13560371
88Increased intramyocellular lipid droplets (HP:0012240)2.13151897
89Diaphragmatic weakness (HP:0009113)2.12943561
90Progressive external ophthalmoplegia (HP:0000590)2.12636528
91Spastic paraparesis (HP:0002313)2.12542517
92Esophageal neoplasm (HP:0100751)2.12009512
93Neoplasm of head and neck (HP:0012288)2.12009512
94Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.09874330
95Decreased activity of mitochondrial respiratory chain (HP:0008972)2.09874330
96Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08438646
97Hypochromic microcytic anemia (HP:0004840)2.08252904
98Progressive muscle weakness (HP:0003323)2.07823991
99Secondary amenorrhea (HP:0000869)2.07418134
100Death in infancy (HP:0001522)2.03816521
101Hypokinesia (HP:0002375)2.02630541
102Exercise intolerance (HP:0003546)2.01871896
103Stomatitis (HP:0010280)2.01679091
104Abnormality of secondary sexual hair (HP:0009888)2.00811151
105Abnormality of the axillary hair (HP:0100134)2.00811151
106Abnormality of dicarboxylic acid metabolism (HP:0010995)2.00201285
107Dicarboxylic aciduria (HP:0003215)2.00201285
108Pancreatic fibrosis (HP:0100732)1.99927226
109Respiratory difficulties (HP:0002880)1.99529012
110Degeneration of anterior horn cells (HP:0002398)1.99313250
111Abnormality of the anterior horn cell (HP:0006802)1.99313250
112Verrucae (HP:0200043)1.99058940
113Papilloma (HP:0012740)1.99058940
114Vacuolated lymphocytes (HP:0001922)1.97354641
115Abnormal delayed hypersensitivity skin test (HP:0002963)1.96889613
116Abnormality of macrophages (HP:0004311)1.96642725
117Epistaxis (HP:0000421)1.95819830
118Progressive macrocephaly (HP:0004481)1.94868622
119Abnormality of DNA repair (HP:0003254)1.93744810
120CNS hypomyelination (HP:0003429)1.93735159
121Chromosomal breakage induced by crosslinking agents (HP:0003221)1.93454853
122Amaurosis fugax (HP:0100576)1.93081722
123Gastrointestinal inflammation (HP:0004386)1.92863180
124Loss of speech (HP:0002371)1.92642675
125Hypochromic anemia (HP:0001931)1.91547666
126Mitochondrial inheritance (HP:0001427)1.89469734
127Albinism (HP:0001022)1.89256819
128Pancreatic cysts (HP:0001737)1.88942050
129Gastrointestinal infarctions (HP:0005244)1.88444348
130Emotional lability (HP:0000712)1.88079037
131Abnormality of the preputium (HP:0100587)1.87697582
132Agammaglobulinemia (HP:0004432)1.86422814
133Aplasia/Hypoplasia of the fovea (HP:0008060)1.86282403
134Hypoplasia of the fovea (HP:0007750)1.86282403
135Hepatosplenomegaly (HP:0001433)1.85620594
136Clubbing of toes (HP:0100760)1.85544108
137Capillary hemangiomas (HP:0005306)1.83700062
138Abnormality of renal resorption (HP:0011038)1.83567370
139Lactic acidosis (HP:0003128)1.82277204
140Panhypogammaglobulinemia (HP:0003139)1.82009833
141Delusions (HP:0000746)1.81999641
142Fatigue (HP:0012378)1.79270337
143Increased IgM level (HP:0003496)1.79048186
144Sparse eyelashes (HP:0000653)1.77699259
145Rhabdomyolysis (HP:0003201)1.76647239
146Chronic mucocutaneous candidiasis (HP:0002728)1.75688338
147Recurrent cutaneous fungal infections (HP:0011370)1.75688338
148Pulmonary fibrosis (HP:0002206)1.75437416
149Chromsome breakage (HP:0040012)1.73899786
150Squamous cell carcinoma (HP:0002860)1.72705999
151Abnormality of glycolysis (HP:0004366)1.72274214
152Sex reversal (HP:0012245)1.72172609
153Abnormal sex determination (HP:0012244)1.72172609
154Renal tubular dysfunction (HP:0000124)1.71703941
155Abnormality of T cells (HP:0002843)1.71393608
156Aplasia/Hypoplasia of the thymus (HP:0010515)1.70995006
157Entropion (HP:0000621)1.70710465
158Pendular nystagmus (HP:0012043)1.70692574
159Neutropenia (HP:0001875)1.70568431
160Poikiloderma (HP:0001029)1.70452293
161Hyperbilirubinemia (HP:0002904)1.69994770
162Recurrent bronchitis (HP:0002837)1.69532246
163Myelodysplasia (HP:0002863)1.68893729
164IgG deficiency (HP:0004315)1.68708384
165Abnormality of the distal phalanges of the toes (HP:0010182)1.68208731
166Acute lymphatic leukemia (HP:0006721)1.67277622
167Basal ganglia calcification (HP:0002135)1.66770750
168Ocular albinism (HP:0001107)1.63657427
169Increased muscle lipid content (HP:0009058)1.63571112

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.48072680
2MUSK4.82397783
3NME23.66257910
4EIF2AK33.46376560
5ERN13.39558716
6STK163.29241596
7VRK22.93071674
8EIF2AK12.81934309
9MKNK22.78976674
10SMG12.76621941
11NLK2.63728473
12TESK22.54909845
13TEC2.42620161
14IRAK42.30448060
15CAMKK22.20100026
16KIT2.11512832
17IRAK32.02697196
18MAP3K102.00930206
19CASK2.00746400
20WEE11.90587173
21MKNK11.88244048
22PIM21.77310137
23BCKDK1.73932724
24BTK1.64768202
25TRIB31.58851968
26CDK191.58609716
27MAP3K121.57804747
28VRK11.49856572
29TAOK11.44244424
30EIF2AK21.36952293
31ARAF1.36026032
32SIK11.34729027
33FLT31.34160380
34MAP2K71.33754974
35FES1.32072388
36TLK11.30275709
37GRK61.28087585
38LRRK21.26566081
39MAPKAPK31.26563404
40MAP3K31.26207520
41CAMK11.25691634
42MAP4K11.25601168
43PAK41.25416949
44NME11.24925537
45MARK31.22184899
46KSR21.20651620
47TXK1.19908532
48EPHA21.19157086
49TESK11.19141768
50PKN21.18894886
51IKBKB1.18702636
52ADRBK21.16162501
53DYRK31.15795576
54SRPK11.14805414
55SIK21.10050692
56TSSK61.09201995
57MAPK131.06654823
58BLK1.02967031
59TBK10.99424464
60YES10.99199005
61MAP3K80.98189893
62SCYL20.96707990
63SYK0.95899601
64IKBKE0.95484651
65BRSK20.93863971
66ACVR1B0.92231951
67RAF10.91532651
68MAP2K30.91442906
69PASK0.90273505
70MAP3K140.89858975
71STK40.89663332
72STK100.89488766
73TIE10.89405205
74ZAP700.87716052
75CLK10.86522596
76CDK90.85794816
77EEF2K0.83638024
78PRKG20.81671028
79TRIM280.80738486
80BUB10.80278965
81CSF1R0.79099646
82KDR0.77815439
83MATK0.77570232
84AURKA0.77400035
85TGFBR20.76946695
86RIPK40.75745489
87PBK0.75301684
88LYN0.75178349
89PRKCI0.74771345
90CCNB10.73164812
91BMX0.72705182
92MAP3K110.68607016
93MAPK150.68151640
94TAOK20.67745624
95HIPK20.66154018
96JAK30.65557129
97PDK20.65077156
98IRAK10.64978422
99CDK70.62395275
100TGFBR10.61339014
101MAP2K60.59272339
102CDK80.58719771
103MAPKAPK50.58016874
104ILK0.57793392
105PAK10.54502088
106CAMK40.54452387
107MAPK40.53645237
108RPS6KB20.53442633
109PIM10.52885796
110EPHB10.52737061
111PRKD20.52158768
112PLK40.51794418
113CDK30.51372502
114CAMKK10.50309764
115STK240.50089778
116GRK10.48843250
117CSNK1G10.48781838
118ATR0.48197965
119MAPK110.47906016
120LCK0.47014678
121MST1R0.45749765
122SIK30.45592254
123IRAK20.45559948
124NEK10.44326061
125TTK0.44108657
126RPS6KA40.43317389
127CHEK10.43263589
128BMPR1B0.42973208
129PLK30.42465550
130ICK0.41147086
131CDK120.40675659
132AURKB0.40097496
133BRAF0.39782020
134TYK20.39751842
135LMTK20.39731404
136MAPKAPK20.39517597
137PLK10.39047835
138MYLK0.38795567
139ZAK0.38348772
140GRK70.36271520
141MAP3K10.36198526
142BMPR20.35500784
143EPHA30.34519273
144DYRK20.34338706
145TAOK30.34301630
146PIK3CG0.33071053
147CSNK2A10.31776432
148CDK40.31138016
149TNK20.30935731
150CSNK1G30.29771723
151MST40.29050278
152MAPK120.28782796
153DAPK10.28473916
154PRPF4B0.27287284
155RPS6KA50.27027146
156BRSK10.26965461

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.35622847
2DNA replication_Homo sapiens_hsa030303.79383252
3Protein export_Homo sapiens_hsa030602.89661405
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.87706273
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.53532888
6RNA polymerase_Homo sapiens_hsa030202.52303685
7Homologous recombination_Homo sapiens_hsa034402.52210236
8Mismatch repair_Homo sapiens_hsa034302.41724588
9Base excision repair_Homo sapiens_hsa034102.39951390
10Pyrimidine metabolism_Homo sapiens_hsa002402.22764493
11Proteasome_Homo sapiens_hsa030501.98328964
12Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.94972880
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.87059532
14Fanconi anemia pathway_Homo sapiens_hsa034601.78378239
15Nucleotide excision repair_Homo sapiens_hsa034201.78019175
16Other glycan degradation_Homo sapiens_hsa005111.77341518
17Spliceosome_Homo sapiens_hsa030401.77255091
18Primary immunodeficiency_Homo sapiens_hsa053401.73948887
19Purine metabolism_Homo sapiens_hsa002301.59404961
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54319051
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.54106309
22Basal transcription factors_Homo sapiens_hsa030221.53075440
23* N-Glycan biosynthesis_Homo sapiens_hsa005101.49088041
24Biosynthesis of amino acids_Homo sapiens_hsa012301.48529582
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.39681163
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.38458577
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37384777
28Vibrio cholerae infection_Homo sapiens_hsa051101.36940533
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.33923551
30Fatty acid elongation_Homo sapiens_hsa000621.33193082
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31127630
32Non-homologous end-joining_Homo sapiens_hsa034501.28326921
33Hematopoietic cell lineage_Homo sapiens_hsa046401.28245350
34Allograft rejection_Homo sapiens_hsa053301.27298128
35Fructose and mannose metabolism_Homo sapiens_hsa000511.27184896
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26318304
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25441178
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24423221
39Measles_Homo sapiens_hsa051621.22524036
40Leishmaniasis_Homo sapiens_hsa051401.21818409
41Herpes simplex infection_Homo sapiens_hsa051681.21229161
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.19462487
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.15295883
44Sphingolipid metabolism_Homo sapiens_hsa006001.14739906
45* Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12359792
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10722215
47Folate biosynthesis_Homo sapiens_hsa007901.09394418
48mRNA surveillance pathway_Homo sapiens_hsa030151.07644480
49p53 signaling pathway_Homo sapiens_hsa041151.06900706
50Collecting duct acid secretion_Homo sapiens_hsa049661.05449036
51Non-small cell lung cancer_Homo sapiens_hsa052231.04052295
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.03578331
53Sulfur relay system_Homo sapiens_hsa041221.03459049
54RNA degradation_Homo sapiens_hsa030181.02717132
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02334549
56Thyroid cancer_Homo sapiens_hsa052161.01596519
57Asthma_Homo sapiens_hsa053100.99509140
58Arachidonic acid metabolism_Homo sapiens_hsa005900.98676059
59Regulation of autophagy_Homo sapiens_hsa041400.96686017
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95059226
61Carbon metabolism_Homo sapiens_hsa012000.90181507
62Galactose metabolism_Homo sapiens_hsa000520.87082511
63* Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85873029
64Oxidative phosphorylation_Homo sapiens_hsa001900.85721547
65Phototransduction_Homo sapiens_hsa047440.85619079
66Viral carcinogenesis_Homo sapiens_hsa052030.84246089
67Cell cycle_Homo sapiens_hsa041100.84207731
68Acute myeloid leukemia_Homo sapiens_hsa052210.83844891
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83388823
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81334680
71Antigen processing and presentation_Homo sapiens_hsa046120.80484342
72B cell receptor signaling pathway_Homo sapiens_hsa046620.79912109
73Graft-versus-host disease_Homo sapiens_hsa053320.79653864
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77937209
75Pertussis_Homo sapiens_hsa051330.77501438
76Chronic myeloid leukemia_Homo sapiens_hsa052200.74646450
77Type I diabetes mellitus_Homo sapiens_hsa049400.72851293
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.71866346
79Epstein-Barr virus infection_Homo sapiens_hsa051690.70307723
80Influenza A_Homo sapiens_hsa051640.69726704
81HTLV-I infection_Homo sapiens_hsa051660.69547189
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67242573
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.66981261
84Pancreatic cancer_Homo sapiens_hsa052120.66249877
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65813959
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.65668867
87Legionellosis_Homo sapiens_hsa051340.65085923
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64860373
89Autoimmune thyroid disease_Homo sapiens_hsa053200.64467148
90RNA transport_Homo sapiens_hsa030130.64115188
91Malaria_Homo sapiens_hsa051440.62572443
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60116643
93Rheumatoid arthritis_Homo sapiens_hsa053230.57562016
94Parkinsons disease_Homo sapiens_hsa050120.57308016
95Bladder cancer_Homo sapiens_hsa052190.56103374
96Tuberculosis_Homo sapiens_hsa051520.54877209
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53960815
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53741534
99Apoptosis_Homo sapiens_hsa042100.52233629
100Osteoclast differentiation_Homo sapiens_hsa043800.52188109
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52121705
102T cell receptor signaling pathway_Homo sapiens_hsa046600.52118683
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50778670
104Glutathione metabolism_Homo sapiens_hsa004800.50053300
105Hepatitis B_Homo sapiens_hsa051610.49910089
106Huntingtons disease_Homo sapiens_hsa050160.48427579
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48158520
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47821469
109Vitamin digestion and absorption_Homo sapiens_hsa049770.46945617
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46791835
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46382706
112Lysosome_Homo sapiens_hsa041420.46150237
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44670304
114mTOR signaling pathway_Homo sapiens_hsa041500.44553107
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42812616
116Viral myocarditis_Homo sapiens_hsa054160.42587680
117Shigellosis_Homo sapiens_hsa051310.41269577
118Salmonella infection_Homo sapiens_hsa051320.40401968
119Sulfur metabolism_Homo sapiens_hsa009200.40322115
120* Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40143057
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38940199
122Hepatitis C_Homo sapiens_hsa051600.38048610
123HIF-1 signaling pathway_Homo sapiens_hsa040660.36957459
124African trypanosomiasis_Homo sapiens_hsa051430.36218178
125Circadian rhythm_Homo sapiens_hsa047100.35828132
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35468938
127Systemic lupus erythematosus_Homo sapiens_hsa053220.35440186
128Alzheimers disease_Homo sapiens_hsa050100.33467151
129TNF signaling pathway_Homo sapiens_hsa046680.33434611
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33415692
131* Metabolic pathways_Homo sapiens_hsa011000.32805871
132Pentose phosphate pathway_Homo sapiens_hsa000300.31861473
133Toxoplasmosis_Homo sapiens_hsa051450.30362569
134One carbon pool by folate_Homo sapiens_hsa006700.26755612
135Phagosome_Homo sapiens_hsa041450.26033105
136Alcoholism_Homo sapiens_hsa050340.25810900

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