B3GNT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a. It plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)6.80806869
2intestinal cholesterol absorption (GO:0030299)5.71881754
3maintenance of gastrointestinal epithelium (GO:0030277)5.60542720
4angiotensin maturation (GO:0002003)5.27415462
5bundle of His cell to Purkinje myocyte communication (GO:0086069)5.02263752
6hemidesmosome assembly (GO:0031581)4.78617362
7UDP-N-acetylglucosamine metabolic process (GO:0006047)4.74092986
8cellular glucuronidation (GO:0052695)4.67589733
9calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.65195896
10uronic acid metabolic process (GO:0006063)4.46637000
11glucuronate metabolic process (GO:0019585)4.46637000
12epithelial structure maintenance (GO:0010669)4.45168184
13citrulline biosynthetic process (GO:0019240)4.43026635
14intestinal epithelial cell development (GO:0060576)4.38610445
15hepatocyte apoptotic process (GO:0097284)4.27379909
16COPI coating of Golgi vesicle (GO:0048205)4.27034654
17Golgi transport vesicle coating (GO:0048200)4.27034654
18NADH metabolic process (GO:0006734)4.20319517
19digestive system process (GO:0022600)4.19641822
20regulation of guanylate cyclase activity (GO:0031282)4.11491701
21positive regulation of pseudopodium assembly (GO:0031274)4.10623130
22transcytosis (GO:0045056)4.00053424
23multicellular organismal water homeostasis (GO:0050891)3.99852642
24vitamin A metabolic process (GO:0006776)3.90323013
25renal filtration (GO:0097205)3.87793223
26vitamin transmembrane transport (GO:0035461)3.78751633
27renal system process involved in regulation of blood volume (GO:0001977)3.75204019
28citrulline metabolic process (GO:0000052)3.72805654
29cellular response to hepatocyte growth factor stimulus (GO:0035729)3.70074067
30response to hepatocyte growth factor (GO:0035728)3.70074067
31purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.69071054
323-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.69071054
33primary alcohol catabolic process (GO:0034310)3.68197551
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.66358679
35antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.66358679
36oligosaccharide biosynthetic process (GO:0009312)3.66223642
37epoxygenase P450 pathway (GO:0019373)3.65874889
38regulation of pseudopodium assembly (GO:0031272)3.61726316
39* O-glycan processing (GO:0016266)3.61506954
40ethanol oxidation (GO:0006069)3.58310397
41ethanol metabolic process (GO:0006067)3.57659395
42bile acid and bile salt transport (GO:0015721)3.57416193
43urea cycle (GO:0000050)3.54952959
44regulation of bile acid biosynthetic process (GO:0070857)3.53954055
45glomerular filtration (GO:0003094)3.51582522
46positive regulation of respiratory burst (GO:0060267)3.51201046
47regulation of water loss via skin (GO:0033561)3.49471375
48diterpenoid biosynthetic process (GO:0016102)3.48467235
49GDP-mannose metabolic process (GO:0019673)3.47296869
50hormone catabolic process (GO:0042447)3.46298544
51negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.43795777
52actin filament depolymerization (GO:0030042)3.42055188
53regulation of systemic arterial blood pressure by hormone (GO:0001990)3.40895554
54regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.40895554
55endocrine process (GO:0050886)3.40895554
56virion attachment to host cell (GO:0019062)3.40339546
57adhesion of symbiont to host cell (GO:0044650)3.40339546
58regulation of cholesterol homeostasis (GO:2000188)3.35626042
59urea metabolic process (GO:0019627)3.34091107
60regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.32401611
61adhesion of symbiont to host (GO:0044406)3.30391377
62low-density lipoprotein particle clearance (GO:0034383)3.29130709
63regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.28166589
64regulation of respiratory burst (GO:0060263)3.27406860
65water homeostasis (GO:0030104)3.24468172
66positive regulation of p38MAPK cascade (GO:1900745)3.22738875
67branching involved in mammary gland duct morphogenesis (GO:0060444)3.22572030
68cell adhesion mediated by integrin (GO:0033627)3.21340298
69flavonoid metabolic process (GO:0009812)3.16324226
70regulation of vitamin metabolic process (GO:0030656)3.13681851
71peptide catabolic process (GO:0043171)3.13329278
72activation of Rac GTPase activity (GO:0032863)3.10040990
73regulation of systemic arterial blood pressure (GO:0003073)3.08963984
74establishment of skin barrier (GO:0061436)3.08576997
75sodium ion homeostasis (GO:0055078)3.06681422
76antigen processing and presentation of endogenous antigen (GO:0019883)3.06011638
77glucose 6-phosphate metabolic process (GO:0051156)3.05061766
78antimicrobial humoral response (GO:0019730)3.03313439
79digestion (GO:0007586)3.03107437
80regulation of metalloenzyme activity (GO:0048552)3.02672882
81peptide hormone processing (GO:0016486)3.02032238
82renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.01005368
83antibacterial humoral response (GO:0019731)2.95473133
84nitrogen cycle metabolic process (GO:0071941)2.95396707
85gap junction assembly (GO:0016264)2.95039002
86establishment of endothelial barrier (GO:0061028)2.94365692
87phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.93291955
88negative regulation of keratinocyte proliferation (GO:0010839)2.92331961
89endocrine pancreas development (GO:0031018)2.91274261
90lipoprotein metabolic process (GO:0042157)2.90935118
91mesodermal cell differentiation (GO:0048333)2.90833046
92sphingomyelin metabolic process (GO:0006684)2.89272223
93drug metabolic process (GO:0017144)2.88864612
94negative regulation of protein tyrosine kinase activity (GO:0061099)2.88139715
95positive regulation of guanylate cyclase activity (GO:0031284)2.87889178
96COPII vesicle coating (GO:0048208)2.87682982
97glutamine family amino acid biosynthetic process (GO:0009084)2.87557157
98fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.86653912
99nucleotide-sugar biosynthetic process (GO:0009226)2.85992223
100hypotonic response (GO:0006971)2.84803340
101sulfation (GO:0051923)2.84756870
102positive regulation of fatty acid beta-oxidation (GO:0032000)2.83351419
103fat-soluble vitamin biosynthetic process (GO:0042362)2.82859600
104regulation of cholesterol storage (GO:0010885)2.82729808
105decidualization (GO:0046697)2.81551339
106auditory receptor cell differentiation (GO:0042491)2.81254769
107proline biosynthetic process (GO:0006561)2.78156507
108regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.77753049
109protein retention in ER lumen (GO:0006621)2.77209892
110excretion (GO:0007588)2.74353219
111glutathione biosynthetic process (GO:0006750)2.73656471
112regulation of transforming growth factor beta1 production (GO:0032908)2.72566407
113positive regulation of epidermal cell differentiation (GO:0045606)2.72432611
114protein autoprocessing (GO:0016540)2.71262503
115pyrimidine-containing compound transmembrane transport (GO:0072531)2.70239066
116nucleoside diphosphate biosynthetic process (GO:0009133)2.69419133
117regulation of interferon-beta biosynthetic process (GO:0045357)2.68824938
118positive regulation of lipoprotein lipase activity (GO:0051006)2.67880896
119positive regulation of triglyceride lipase activity (GO:0061365)2.67880896
120lipoprotein transport (GO:0042953)2.65765570
121protein-lipid complex assembly (GO:0065005)2.65520221
122retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.64625076
123plasma lipoprotein particle assembly (GO:0034377)2.61927474
124primary alcohol metabolic process (GO:0034308)2.61593075
125phospholipid scrambling (GO:0017121)2.60864385
126cyclooxygenase pathway (GO:0019371)2.60838422
127receptor guanylyl cyclase signaling pathway (GO:0007168)2.60733960
128very-low-density lipoprotein particle assembly (GO:0034379)2.60492715
129positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.59476655
130positive regulation of protein localization to plasma membrane (GO:1903078)2.58772556
131amyloid precursor protein metabolic process (GO:0042982)2.58534118
132ventricular cardiac muscle cell action potential (GO:0086005)2.57565015
133desmosome organization (GO:0002934)2.57293076
134apoptotic cell clearance (GO:0043277)2.57201653
135regulation of Golgi to plasma membrane protein transport (GO:0042996)2.55236581
136drug catabolic process (GO:0042737)2.53585781
137cytoskeletal anchoring at plasma membrane (GO:0007016)2.51975800
138regulation of viral release from host cell (GO:1902186)2.51466910
139skin morphogenesis (GO:0043589)2.50745301
140glandular epithelial cell differentiation (GO:0002067)2.49095223
141vascular endothelial growth factor signaling pathway (GO:0038084)2.48373860
142positive regulation of Cdc42 GTPase activity (GO:0043089)2.47729024
143thrombin receptor signaling pathway (GO:0070493)2.47392363
144regulation of integrin activation (GO:0033623)2.46403403
145protein kinase C signaling (GO:0070528)2.45321203
146regulation of cellular extravasation (GO:0002691)2.44261038
147sequestering of metal ion (GO:0051238)2.43382814
148diol metabolic process (GO:0034311)2.42966701
149cell differentiation involved in embryonic placenta development (GO:0060706)2.42894175
150phospholipid efflux (GO:0033700)2.42688763
151L-alpha-amino acid transmembrane transport (GO:1902475)2.42457885
152tight junction assembly (GO:0070830)2.41685324
153epithelial cell-cell adhesion (GO:0090136)2.40310545
154maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.39880232
155sulfate transmembrane transport (GO:1902358)2.39554150
156regulation of chemokine secretion (GO:0090196)2.37888968
157endothelial tube morphogenesis (GO:0061154)2.37787167
158morphogenesis of an endothelium (GO:0003159)2.37787167
159substrate-dependent cell migration (GO:0006929)2.37381473
160branching involved in labyrinthine layer morphogenesis (GO:0060670)2.36247798
161leukocyte tethering or rolling (GO:0050901)2.35703379
162regulation of podosome assembly (GO:0071801)2.35356298
163positive regulation of fatty acid biosynthetic process (GO:0045723)2.34793130
164regulation of p38MAPK cascade (GO:1900744)2.34624802
165protein localization to endosome (GO:0036010)2.32697802
166sterol homeostasis (GO:0055092)2.30346399
167cholesterol transport (GO:0030301)2.29279916
168sterol transport (GO:0015918)2.29279916
169cholesterol homeostasis (GO:0042632)2.27957426
170nitric oxide biosynthetic process (GO:0006809)2.27757720
171thyroid hormone metabolic process (GO:0042403)2.27407320
172trophectodermal cell differentiation (GO:0001829)2.27239334
173interferon-gamma secretion (GO:0072643)2.27234833

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.15575484
2CDX2_20551321_ChIP-Seq_CACO-2_Human3.34069012
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.22082519
4* SOX2_27498859_Chip-Seq_STOMACH_Mouse3.11013108
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.96373769
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.69995400
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.55079263
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.50294213
9GATA4_25053715_ChIP-Seq_YYC3_Human2.40352857
10SOX2_20726797_ChIP-Seq_SW620_Human2.36734253
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.33584663
12* GATA6_25053715_ChIP-Seq_YYC3_Human2.28971845
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.22336897
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.21567628
15STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.15064484
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14298665
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.14128242
18KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.10762869
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.08811894
20CLOCK_20551151_ChIP-Seq_293T_Human2.08081172
21ESR2_21235772_ChIP-Seq_MCF-7_Human2.06541647
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.01930028
23GATA1_22025678_ChIP-Seq_K562_Human1.95981437
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.95579153
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.94654257
26* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.91358620
27SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.90170665
28GATA2_21666600_ChIP-Seq_HMVEC_Human1.87503535
29HIF1A_21447827_ChIP-Seq_MCF-7_Human1.86912769
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.86203642
31RXR_22158963_ChIP-Seq_LIVER_Mouse1.83668798
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.81981701
33RACK7_27058665_Chip-Seq_MCF-7_Human1.77781813
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76703639
35* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.69622720
36ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.66982729
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58330608
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57865268
39* ATF3_27146783_Chip-Seq_COLON_Human1.56376098
40* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.53057195
41* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.53057195
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.52750131
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.52411223
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51627057
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51542081
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50688515
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.50643164
48MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48699426
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48474643
50FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.47280891
51* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.46125620
52RUNX1_27514584_Chip-Seq_MCF-7_Human1.44114028
53GATA1_19941826_ChIP-Seq_K562_Human1.36806414
54ZNF263_19887448_ChIP-Seq_K562_Human1.36381791
55ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35198646
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.35010222
57JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35007744
58* KLF5_25053715_ChIP-Seq_YYC3_Human1.33766478
59IRF8_27001747_Chip-Seq_BMDM_Mouse1.33597913
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.33341416
61GATA2_19941826_ChIP-Seq_K562_Human1.29105362
62BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.26923940
63UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25236780
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24291794
65ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.24122341
66LXR_22292898_ChIP-Seq_THP-1_Human1.23531521
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22873894
68ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22867347
69P63_26484246_Chip-Seq_KERATINOCYTES_Human1.21484207
70NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20225576
71IRF8_21731497_ChIP-ChIP_J774_Mouse1.20169280
72SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18257010
73FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17686911
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16963246
75STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.15915526
76* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15816195
77TP63_22573176_ChIP-Seq_HFKS_Human1.14999082
78SPI1_23127762_ChIP-Seq_K562_Human1.14516771
79STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11271347
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09272059
81JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09183597
82EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08707682
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07547264
84TET1_21451524_ChIP-Seq_MESCs_Mouse1.06772557
85NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05690189
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05336389
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05092034
88GATA3_24758297_ChIP-Seq_MCF-7_Human1.04652766
89P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04312646
90TCF7_22412390_ChIP-Seq_EML_Mouse1.02005121
91TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01940180
92VDR_24763502_ChIP-Seq_THP-1_Human1.01220469
93* CREB1_26743006_Chip-Seq_LNCaP_Human1.00956170
94PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.00604738
95TCF4_18268006_ChIP-ChIP_LS174T_Human1.00601821
96AHR_22903824_ChIP-Seq_MCF-7_Human1.00191140
97E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99569810
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98695420
99FOXA2_19822575_ChIP-Seq_HepG2_Human0.98544575
100TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98528052
101NCOR1_26117541_ChIP-Seq_K562_Human0.96814738
102SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96227113
103KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96158419
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95639994
105SMC4_20622854_ChIP-Seq_HELA_Human0.95152054
106ERG_21242973_ChIP-ChIP_JURKAT_Human0.94511986
107* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94180942
108* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93986399
109SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93431719
110SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92400374
111CJUN_26792858_Chip-Seq_BT549_Human0.92357339
112MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.92169291
113POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91786849
114* HNF4A_19822575_ChIP-Seq_HepG2_Human0.91264948
115SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.90832884
116RUNX1_22412390_ChIP-Seq_EML_Mouse0.90137902
117* MAF_26560356_Chip-Seq_TH1_Human0.90114450
118JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.89913329
119FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.89868044
120ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89573717
121AR_21909140_ChIP-Seq_LNCAP_Human0.89171468
122AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88969170
123* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87738672
124* FOXA1_25552417_ChIP-Seq_VCAP_Human0.86084444
125* BCOR_27268052_Chip-Seq_Bcells_Human0.83867881
126CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83721546
127CTCF_27219007_Chip-Seq_Bcells_Human0.83412746
128KDM2B_26808549_Chip-Seq_K562_Human0.82242697
129EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.81371567
130RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.81252503
131SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.80491460
132* P68_20966046_ChIP-Seq_HELA_Human0.78929300

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.48347900
2MP0005360_urolithiasis3.71822710
3MP0008004_abnormal_stomach_pH3.67385267
4MP0004264_abnormal_extraembryonic_tissu3.63838512
5MP0001666_abnormal_nutrient_absorption3.29801007
6MP0006054_spinal_hemorrhage3.16682910
7MP0003300_gastrointestinal_ulcer3.13013496
8MP0000566_synostosis2.84154876
9MP0003866_abnormal_defecation2.68259966
10MP0001873_stomach_inflammation2.51696964
11MP0003705_abnormal_hypodermis_morpholog2.36871167
12MP0000462_abnormal_digestive_system2.31040245
13MP0009840_abnormal_foam_cell2.29026603
14MP0010352_gastrointestinal_tract_polyps2.22023257
15MP0010155_abnormal_intestine_physiology2.20231564
16MP0010368_abnormal_lymphatic_system2.16491975
17MP0005167_abnormal_blood-brain_barrier2.14212501
18MP0000537_abnormal_urethra_morphology2.05462733
19MP0009379_abnormal_foot_pigmentation2.05270946
20MP0003724_increased_susceptibility_to2.01260016
21MP0005409_darkened_coat_color1.95951823
22MP0001663_abnormal_digestive_system1.82546183
23MP0005083_abnormal_biliary_tract1.77579868
24MP0003183_abnormal_peptide_metabolism1.76324417
25MP0003252_abnormal_bile_duct1.72746442
26MP0001879_abnormal_lymphatic_vessel1.72531502
27MP0002877_abnormal_melanocyte_morpholog1.70357095
28MP0004947_skin_inflammation1.70205547
29MP0005381_digestive/alimentary_phenotyp1.69132689
30MP0000678_abnormal_parathyroid_gland1.65838986
31MP0000490_abnormal_crypts_of1.64802168
32MP0005451_abnormal_body_composition1.64614712
33MP0001664_abnormal_digestion1.62636562
34MP0000477_abnormal_intestine_morphology1.62202629
35MP0001849_ear_inflammation1.61136510
36MP0005085_abnormal_gallbladder_physiolo1.57751750
37MP0000467_abnormal_esophagus_morphology1.55537212
38MP0003191_abnormal_cellular_cholesterol1.53237713
39MP0003566_abnormal_cell_adhesion1.51455059
40MP0010329_abnormal_lipoprotein_level1.47843744
41MP0008875_abnormal_xenobiotic_pharmacok1.41623056
42MP0003303_peritoneal_inflammation1.39855068
43MP0005310_abnormal_salivary_gland1.35293620
44MP0002139_abnormal_hepatobiliary_system1.34825340
45MP0004272_abnormal_basement_membrane1.31185898
46MP0005670_abnormal_white_adipose1.28384967
47MP0009643_abnormal_urine_homeostasis1.28270796
48MP0003453_abnormal_keratinocyte_physiol1.28267394
49MP0003868_abnormal_feces_composition1.26371265
50MP0010678_abnormal_skin_adnexa1.20418097
51MP0002796_impaired_skin_barrier1.19365964
52MP0003436_decreased_susceptibility_to1.19214070
53MP0005058_abnormal_lysosome_morphology1.16482964
54MP0000383_abnormal_hair_follicle1.13774895
55MP0000762_abnormal_tongue_morphology1.09460984
56MP0004858_abnormal_nervous_system1.09431063
57MP0000609_abnormal_liver_physiology1.08260556
58MP0004043_abnormal_pH_regulation1.07552470
59MP0003283_abnormal_digestive_organ1.06564472
60MP0000538_abnormal_urinary_bladder1.05860083
61MP0000470_abnormal_stomach_morphology1.05598883
62MP0004147_increased_porphyrin_level1.04612856
63MP0010771_integument_phenotype1.04376827
64MP0000377_abnormal_hair_follicle1.03191477
65MP0005023_abnormal_wound_healing1.02953588
66MP0001533_abnormal_skeleton_physiology1.02177118
67MP0000013_abnormal_adipose_tissue1.01293626
68MP0009785_altered_susceptibility_to1.00692070
69MP0005275_abnormal_skin_tensile1.00430615
70MP0004019_abnormal_vitamin_homeostasis1.00119997
71MP0000465_gastrointestinal_hemorrhage0.99725786
72MP0002138_abnormal_hepatobiliary_system0.99557000
73MP0001756_abnormal_urination0.97263451
74MP0003806_abnormal_nucleotide_metabolis0.96751650
75MP0005076_abnormal_cell_differentiation0.96710762
76MP0001845_abnormal_inflammatory_respons0.96657038
77MP0000579_abnormal_nail_morphology0.96507647
78MP0005365_abnormal_bile_salt0.96245207
79MP0005332_abnormal_amino_acid0.95955722
80MP0005025_abnormal_response_to0.95800420
81MP0005666_abnormal_adipose_tissue0.95287253
82MP0001765_abnormal_ion_homeostasis0.94757789
83MP0001216_abnormal_epidermal_layer0.94727584
84MP0002876_abnormal_thyroid_physiology0.94473834
85MP0000627_abnormal_mammary_gland0.93636574
86MP0005501_abnormal_skin_physiology0.91870533
87MP0003045_fibrosis0.91436833
88MP0005464_abnormal_platelet_physiology0.90905739
89MP0002098_abnormal_vibrissa_morphology0.90608887
90MP0005165_increased_susceptibility_to0.89978613
91MP0005166_decreased_susceptibility_to0.89960094
92MP0002254_reproductive_system_inflammat0.89715304
93MP0001881_abnormal_mammary_gland0.88425243
94MP0002909_abnormal_adrenal_gland0.87589956
95MP0003941_abnormal_skin_development0.85499475
96MP0000249_abnormal_blood_vessel0.85096291
97MP0004185_abnormal_adipocyte_glucose0.85070215
98MP0002166_altered_tumor_susceptibility0.84698224
99MP0002060_abnormal_skin_morphology0.84489503
100MP0002693_abnormal_pancreas_physiology0.83621910
101MP0000003_abnormal_adipose_tissue0.83313492
102MP0002148_abnormal_hypersensitivity_rea0.80928560
103MP0005319_abnormal_enzyme/_coenzyme0.80772707
104MP0005636_abnormal_mineral_homeostasis0.80511820
105MP0001191_abnormal_skin_condition0.79688311
106MP0005257_abnormal_intraocular_pressure0.77975577
107MP0002419_abnormal_innate_immunity0.77910234
108MP0002136_abnormal_kidney_physiology0.77699743
109MP0004782_abnormal_surfactant_physiolog0.76383722
110MP0003828_pulmonary_edema0.75890794
111MP0003091_abnormal_cell_migration0.75020113
112MP0009931_abnormal_skin_appearance0.74558298
113MP0003315_abnormal_perineum_morphology0.73555763
114MP0008469_abnormal_protein_level0.72402835
115MP0005375_adipose_tissue_phenotype0.72172072
116MP0009333_abnormal_splenocyte_physiolog0.71281468
117MP0000604_amyloidosis0.70892213
118MP0003075_altered_response_to0.70013577
119MP0000858_altered_metastatic_potential0.69740395
120MP0005387_immune_system_phenotype0.69145841
121MP0001790_abnormal_immune_system0.69145841
122MP0009780_abnormal_chondrocyte_physiolo0.68720023
123MP0002006_tumorigenesis0.68368697
124MP0010307_abnormal_tumor_latency0.67747516
125MP0003879_abnormal_hair_cell0.67178111
126MP0002118_abnormal_lipid_homeostasis0.67149664
127MP0002896_abnormal_bone_mineralization0.66718588
128MP0002089_abnormal_postnatal_growth/wei0.61208910
129MP0001764_abnormal_homeostasis0.55019254
130MP0003329_amyloid_beta_deposits0.51396058
131MP0005584_abnormal_enzyme/coenzyme_acti0.51084363
132MP0000367_abnormal_coat/_hair0.50547436

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.20015049
2Ileus (HP:0002595)5.06223204
3Decreased circulating renin level (HP:0003351)4.20218638
4Abnormality of renin-angiotensin system (HP:0000847)4.02634923
5Pustule (HP:0200039)3.84285021
6Autoimmune thrombocytopenia (HP:0001973)3.67397733
7Abdominal distention (HP:0003270)3.60067511
8Milia (HP:0001056)3.58283321
9Onycholysis (HP:0001806)3.46300460
10Malnutrition (HP:0004395)3.43724628
11Chronic bronchitis (HP:0004469)3.35069128
12Nonimmune hydrops fetalis (HP:0001790)3.33398349
13Abnormal hair laboratory examination (HP:0003328)3.24193934
14Polycythemia (HP:0001901)3.23542603
15Esophageal varix (HP:0002040)3.20952375
16Hyperaldosteronism (HP:0000859)3.18931514
17Flat acetabular roof (HP:0003180)3.07347301
18Atrophic scars (HP:0001075)3.06615558
19Alkalosis (HP:0001948)3.05366620
20Metabolic alkalosis (HP:0200114)3.03076864
21Micronodular cirrhosis (HP:0001413)3.02436363
22Abnormality of glutamine family amino acid metabolism (HP:0010902)2.97903654
23Vacuolated lymphocytes (HP:0001922)2.93042009
24Hyperactive renin-angiotensin system (HP:0000841)2.90209268
25Urinary glycosaminoglycan excretion (HP:0003541)2.89644791
26Mucopolysacchariduria (HP:0008155)2.89644791
27Interstitial pulmonary disease (HP:0006530)2.85235321
28Hydroxyprolinuria (HP:0003080)2.83056036
29Abnormality of proline metabolism (HP:0010907)2.83056036
30Fragile nails (HP:0001808)2.74766450
31Hyponatremia (HP:0002902)2.71184845
32Acanthocytosis (HP:0001927)2.66145272
33Abnormality of the gastric mucosa (HP:0004295)2.65948907
34Hyperkalemia (HP:0002153)2.64616136
35Hypoglycemic coma (HP:0001325)2.61632334
36Abnormality of mucopolysaccharide metabolism (HP:0011020)2.61405998
37Abnormality of polysaccharide metabolism (HP:0011012)2.61405998
38Abnormality of glycosaminoglycan metabolism (HP:0004371)2.61405998
39Conjugated hyperbilirubinemia (HP:0002908)2.57824230
40Rectal prolapse (HP:0002035)2.54195226
41Alopecia of scalp (HP:0002293)2.52819843
42Abnormality of the distal phalanx of the thumb (HP:0009617)2.52095050
43Symptomatic seizures (HP:0011145)2.51050004
44Abnormality of carpal bone ossification (HP:0006257)2.48098002
45Gout (HP:0001997)2.47275747
46Hyperinsulinemic hypoglycemia (HP:0000825)2.46604274
47Hypotension (HP:0002615)2.46140645
48Focal segmental glomerulosclerosis (HP:0000097)2.45721419
49Hematochezia (HP:0002573)2.42528457
50Systemic lupus erythematosus (HP:0002725)2.40530196
51Widely patent fontanelles and sutures (HP:0004492)2.39901504
52Dysostosis multiplex (HP:0000943)2.38409495
53Nasal polyposis (HP:0100582)2.36890886
54Villous atrophy (HP:0011473)2.34918266
55Abnormality of small intestinal villus morphology (HP:0011472)2.34918266
56Spinal cord compression (HP:0002176)2.32318806
57Plantar hyperkeratosis (HP:0007556)2.30559192
58Gastrointestinal dysmotility (HP:0002579)2.30400051
59Hypobetalipoproteinemia (HP:0003563)2.30041952
60Distal lower limb amyotrophy (HP:0008944)2.29960381
61Hypoglycemic seizures (HP:0002173)2.29491711
62Chronic diarrhea (HP:0002028)2.29277885
63Abnormality of chloride homeostasis (HP:0011422)2.27907335
64Cupped ribs (HP:0000887)2.27335728
65Renal salt wasting (HP:0000127)2.22916093
66Abnormal biliary tract morphology (HP:0012440)2.21602355
67Late onset (HP:0003584)2.21471325
68Abnormality of monocarboxylic acid metabolism (HP:0010996)2.20578286
69Autoimmune hemolytic anemia (HP:0001890)2.20000042
70Hyperparathyroidism (HP:0000843)2.17243023
71Abnormality of the nasal mucosa (HP:0000433)2.16567569
72Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.15608001
73Growth hormone excess (HP:0000845)2.14609973
74Fatigue (HP:0012378)2.14336517
75Hyperuricemia (HP:0002149)2.12729075
76Increased purine levels (HP:0004368)2.12729075
77Ventricular tachycardia (HP:0004756)2.11789586
78Vascular calcification (HP:0004934)2.11246079
79Abnormality of purine metabolism (HP:0004352)2.11007320
80Woolly hair (HP:0002224)2.10830510
81Fat malabsorption (HP:0002630)2.10759783
82Dehydration (HP:0001944)2.08882594
83Upper limb amyotrophy (HP:0009129)2.08580228
84Distal upper limb amyotrophy (HP:0007149)2.08580228
85Abnormal ossification of hand bones (HP:0005921)2.08300156
86Abnormality of complement system (HP:0005339)2.07106711
87Increased cerebral lipofuscin (HP:0011813)2.04885660
88Curly hair (HP:0002212)2.04306224
89Abnormal hand bone ossification (HP:0010660)2.03363958
90Axonal loss (HP:0003447)2.03291790
91Flattened epiphyses (HP:0003071)2.03193364
92Subcapsular cataract (HP:0000523)2.02762481
93Pili torti (HP:0003777)2.01971898
94Pterygium (HP:0001059)2.01732442
95Abnormal blistering of the skin (HP:0008066)2.01346803
96Subacute progressive viral hepatitis (HP:0006572)2.00872536
97Fragile skin (HP:0001030)2.00811918
98Hyperglycemia (HP:0003074)2.00809484
99Abnormality of vitamin metabolism (HP:0100508)2.00272031
100Increased mean platelet volume (HP:0011877)2.00234147
101Cervical subluxation (HP:0003308)2.00097115
102Thin bony cortex (HP:0002753)1.99728430
103Deep venous thrombosis (HP:0002625)1.99591444
104Hypoplasia of dental enamel (HP:0006297)1.98354781
105Mildly elevated creatine phosphokinase (HP:0008180)1.97905564
106Severe short stature (HP:0003510)1.96432345
107Adrenal overactivity (HP:0002717)1.94867871
108Cheilitis (HP:0100825)1.94209090
109Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.93751817
110Broad face (HP:0000283)1.92451425
111Ureteral stenosis (HP:0000071)1.91569665
112Abnormal platelet function (HP:0011869)1.91304792
113Impaired platelet aggregation (HP:0003540)1.91304792
114Progressive hearing impairment (HP:0001730)1.90238898
115Abnormality of sodium homeostasis (HP:0010931)1.90094294
116Spontaneous hematomas (HP:0007420)1.90063495
117Nephritis (HP:0000123)1.89767375
118Complement deficiency (HP:0004431)1.89147586
119Cardiovascular calcification (HP:0011915)1.89112701
120Abnormal vertebral ossification (HP:0100569)1.88825545
121Abnormality of the distal phalanges of the toes (HP:0010182)1.88138042
122Hyperphosphatemia (HP:0002905)1.87238571
123Ureteral obstruction (HP:0006000)1.86666740
124Mesangial abnormality (HP:0001966)1.86107203
125Eczematoid dermatitis (HP:0000976)1.86075620
126Poikilocytosis (HP:0004447)1.85649118
127Insulin resistance (HP:0000855)1.85613735
128Hyperammonemia (HP:0001987)1.85203447
129Abnormality of the vitamin B12 metabolism (HP:0004341)1.84899605
130Steatorrhea (HP:0002570)1.84641925
131Palmoplantar hyperkeratosis (HP:0000972)1.83959173
132Wide cranial sutures (HP:0010537)1.83689513
133Increased IgE level (HP:0003212)1.83071639
134Glomerulosclerosis (HP:0000096)1.82673360
135Hemorrhage of the eye (HP:0011885)1.82494253
136Bone pain (HP:0002653)1.82412142
137Palpitations (HP:0001962)1.82342130
138Abnormal platelet volume (HP:0011876)1.81905577
139Biliary tract neoplasm (HP:0100574)1.81318282
140Abnormality of potassium homeostasis (HP:0011042)1.80973602
141Intrahepatic cholestasis (HP:0001406)1.80801883
142Glomerulonephritis (HP:0000099)1.80561005
143Hypolipoproteinemia (HP:0010981)1.79913623
144Abnormality of macrophages (HP:0004311)1.79481675
145Progressive sensorineural hearing impairment (HP:0000408)1.79414338
146Short nail (HP:0001799)1.78806960
147Xanthomatosis (HP:0000991)1.78568796
148Popliteal pterygium (HP:0009756)1.77491748
149Congenital sensorineural hearing impairment (HP:0008527)1.76333874
150Abnormal tarsal ossification (HP:0008369)1.76218255
151Hypoalbuminemia (HP:0003073)1.74262313
152Abnormal albumin level (HP:0012116)1.74262313
153Pigmentary retinal degeneration (HP:0001146)1.74050796
154Reticulocytosis (HP:0001923)1.74047645
155Aneurysm (HP:0002617)1.73872341

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.39025188
2MST43.79047626
3KDR3.72983936
4FRK3.52338808
5ERN13.35780183
6MST1R3.29881658
7TIE12.59861008
8PTK62.56175502
9RIPK12.54477428
10PRKG22.46274416
11LMTK22.38567632
12MAP2K22.13592123
13TRIB31.92566808
14PKN21.91736415
15STK101.84331372
16PTK21.81052851
17ACVR1B1.76011333
18MAP3K21.70356241
19TGFBR21.62174424
20MET1.59675283
21EPHB11.56936096
22TESK11.56179812
23SMG11.52184175
24PAK41.47308510
25MAP3K121.45573799
26NME11.44125900
27MAP3K31.41616118
28TBK11.40919188
29NME21.40423168
30STK391.38697156
31FER1.34887496
32STK241.34669610
33MAP3K101.34604203
34EPHB21.31652621
35GRK61.27871478
36ERBB41.27847507
37TAOK31.24762135
38LRRK21.24179683
39FGFR41.16947020
40JAK31.07268058
41CSK1.05266292
42ICK1.02401917
43TYK21.02387525
44SCYL20.99935065
45TGFBR10.97739838
46MAP2K10.97208934
47TESK20.92975396
48BMX0.89440710
49MAP4K10.89281075
50ZAP700.89269327
51FLT30.88265014
52PBK0.87861238
53MAP3K140.85374739
54PIM20.85326791
55INSRR0.83095952
56JAK10.82120436
57MAP3K10.81707466
58MYLK0.75306138
59DMPK0.74066707
60PDGFRA0.73647104
61EEF2K0.73557207
62NUAK10.73482237
63MAPK150.73353337
64MAP3K110.72750822
65MATK0.72697807
66LATS10.72112419
67MAP3K80.71163251
68PRKCI0.70065397
69TTN0.68895145
70TAOK10.67339762
71RIPK40.66803592
72JAK20.65813034
73CDK60.64273273
74MAPKAPK30.62605806
75PASK0.61806827
76AKT30.60321744
77CHUK0.60048600
78KSR20.59820804
79CDC42BPA0.59094582
80IKBKE0.57896911
81IRAK30.56567092
82MAP2K30.52424007
83DYRK1B0.50889132
84OXSR10.50635322
85FGFR30.49317430
86STK30.49264464
87EGFR0.47509656
88RPS6KA40.47355045
89PIK3CA0.46850484
90ERBB20.46654996
91TRPM70.45527401
92ITK0.43816115
93PRKAA20.43124413
94BLK0.41805476
95WNK40.41551952
96GSK3A0.41124290
97EPHA30.40599148
98PDGFRB0.40111741
99MAPKAPK20.39168485
100CDK120.38927463
101SRC0.38337149
102DDR20.37485598
103MAP2K60.37304920
104MAPK110.37102024
105STK380.35792724
106CDK90.35301920
107CAMK2G0.35301580
108CAMK2D0.34971172
109NEK60.34090084
110HIPK20.32699004
111PAK30.32618740
112ABL20.32333984
113PAK20.31911394
114NTRK10.30695200
115PRPF4B0.29641199
116GRK10.28989286
117PDPK10.28905827
118CDK80.28856497
119MAP3K90.28671822
120NEK10.28334365
121SIK10.28301613
122RPS6KB20.28033252
123ARAF0.27750004
124RET0.26158436
125ILK0.26022068
126IGF1R0.25740008
127MELK0.24849321
128RPS6KA20.24658065
129SIK30.24127798
130DAPK10.24001246
131EIF2AK10.23165285
132IRAK10.22219381
133MAP3K60.19539372
134MTOR0.19512029
135PRKD20.18444671
136PRKCD0.17415263
137BCR0.16085376

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.30307085
2Fat digestion and absorption_Homo sapiens_hsa049753.72378597
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.68304393
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.26993389
5Mineral absorption_Homo sapiens_hsa049783.22755913
6Sulfur metabolism_Homo sapiens_hsa009203.16236951
7Renin-angiotensin system_Homo sapiens_hsa046142.64259172
8Caffeine metabolism_Homo sapiens_hsa002322.53935417
9Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.47514700
10Galactose metabolism_Homo sapiens_hsa000522.29122669
11Vitamin digestion and absorption_Homo sapiens_hsa049772.25977253
12Drug metabolism - other enzymes_Homo sapiens_hsa009832.14636047
13Chemical carcinogenesis_Homo sapiens_hsa052042.09500723
14Retinol metabolism_Homo sapiens_hsa008302.06408017
15Steroid hormone biosynthesis_Homo sapiens_hsa001401.99466903
16Carbohydrate digestion and absorption_Homo sapiens_hsa049731.91812589
17Phenylalanine metabolism_Homo sapiens_hsa003601.87320925
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.63276907
19Starch and sucrose metabolism_Homo sapiens_hsa005001.60493141
20Folate biosynthesis_Homo sapiens_hsa007901.56381041
21Bile secretion_Homo sapiens_hsa049761.53280800
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.49592983
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.44229432
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40644304
25Protein digestion and absorption_Homo sapiens_hsa049741.33486219
26Histidine metabolism_Homo sapiens_hsa003401.30565526
27Fructose and mannose metabolism_Homo sapiens_hsa000511.29030885
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.28222180
29Nitrogen metabolism_Homo sapiens_hsa009101.25625849
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.25527232
31Adherens junction_Homo sapiens_hsa045201.24794474
32Tyrosine metabolism_Homo sapiens_hsa003501.23980621
33Toxoplasmosis_Homo sapiens_hsa051451.15721970
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10716252
35Legionellosis_Homo sapiens_hsa051341.09235073
36Salmonella infection_Homo sapiens_hsa051321.03402546
37Leishmaniasis_Homo sapiens_hsa051401.03167085
38Small cell lung cancer_Homo sapiens_hsa052221.02685941
39Other glycan degradation_Homo sapiens_hsa005111.02327707
40Lysosome_Homo sapiens_hsa041421.02243796
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01793135
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00907071
43Sphingolipid metabolism_Homo sapiens_hsa006001.00296756
44Tryptophan metabolism_Homo sapiens_hsa003800.99023979
45Thyroid cancer_Homo sapiens_hsa052160.98875885
46Arachidonic acid metabolism_Homo sapiens_hsa005900.96594979
47Tight junction_Homo sapiens_hsa045300.96552293
48Glutathione metabolism_Homo sapiens_hsa004800.95970574
49Shigellosis_Homo sapiens_hsa051310.94561390
50Hepatitis C_Homo sapiens_hsa051600.94549932
51Bladder cancer_Homo sapiens_hsa052190.93096751
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.92859783
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92524788
54TNF signaling pathway_Homo sapiens_hsa046680.92290736
55Hematopoietic cell lineage_Homo sapiens_hsa046400.91890841
56Pertussis_Homo sapiens_hsa051330.89922010
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88137910
58ABC transporters_Homo sapiens_hsa020100.87497545
59African trypanosomiasis_Homo sapiens_hsa051430.86815668
60PPAR signaling pathway_Homo sapiens_hsa033200.86473190
61Sulfur relay system_Homo sapiens_hsa041220.84521546
62* Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84180138
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82835186
64Linoleic acid metabolism_Homo sapiens_hsa005910.79811969
65Amoebiasis_Homo sapiens_hsa051460.79236721
66Fatty acid degradation_Homo sapiens_hsa000710.78386302
67Pancreatic secretion_Homo sapiens_hsa049720.74808010
68Thyroid hormone synthesis_Homo sapiens_hsa049180.74224323
69Influenza A_Homo sapiens_hsa051640.74146357
70Apoptosis_Homo sapiens_hsa042100.73963381
71Focal adhesion_Homo sapiens_hsa045100.73912354
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73424552
73Osteoclast differentiation_Homo sapiens_hsa043800.73143660
74ECM-receptor interaction_Homo sapiens_hsa045120.72947658
75Malaria_Homo sapiens_hsa051440.71847487
76Insulin resistance_Homo sapiens_hsa049310.71011094
77Glycerolipid metabolism_Homo sapiens_hsa005610.70247175
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66474893
79Chronic myeloid leukemia_Homo sapiens_hsa052200.64883424
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63738617
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62730941
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62693769
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62468398
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62098838
85Fatty acid biosynthesis_Homo sapiens_hsa000610.61626043
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59300403
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59225873
88Antigen processing and presentation_Homo sapiens_hsa046120.59106925
89Tuberculosis_Homo sapiens_hsa051520.59100065
90Vibrio cholerae infection_Homo sapiens_hsa051100.58432232
91Complement and coagulation cascades_Homo sapiens_hsa046100.57947797
92Biosynthesis of amino acids_Homo sapiens_hsa012300.56327239
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56299050
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55521580
95Pentose phosphate pathway_Homo sapiens_hsa000300.55128450
96Arginine biosynthesis_Homo sapiens_hsa002200.55087197
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55059478
98N-Glycan biosynthesis_Homo sapiens_hsa005100.54977959
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54742391
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53962454
101Type II diabetes mellitus_Homo sapiens_hsa049300.53551479
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.53223045
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53160786
104Proteoglycans in cancer_Homo sapiens_hsa052050.52813573
105Selenocompound metabolism_Homo sapiens_hsa004500.52397937
106Pancreatic cancer_Homo sapiens_hsa052120.52323481
107Carbon metabolism_Homo sapiens_hsa012000.50827241
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50389206
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.48686762
110VEGF signaling pathway_Homo sapiens_hsa043700.46946791
111Prolactin signaling pathway_Homo sapiens_hsa049170.46163302
112Gastric acid secretion_Homo sapiens_hsa049710.45611229
113Fatty acid metabolism_Homo sapiens_hsa012120.42512073
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42394984
115Platelet activation_Homo sapiens_hsa046110.41984010
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.41803520
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41717922
118Arginine and proline metabolism_Homo sapiens_hsa003300.39776257
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.39419708
120Ether lipid metabolism_Homo sapiens_hsa005650.38995315
121Peroxisome_Homo sapiens_hsa041460.38904582
122Measles_Homo sapiens_hsa051620.36316022
123HIF-1 signaling pathway_Homo sapiens_hsa040660.36181065
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.35914601
125Notch signaling pathway_Homo sapiens_hsa043300.33126582
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.32881943
127Pyruvate metabolism_Homo sapiens_hsa006200.30751358
128beta-Alanine metabolism_Homo sapiens_hsa004100.30187339
129* Metabolic pathways_Homo sapiens_hsa011000.21542663
130Endocytosis_Homo sapiens_hsa041440.20858684
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15187123
132Insulin signaling pathway_Homo sapiens_hsa049100.12517253
133AMPK signaling pathway_Homo sapiens_hsa041520.11154019

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