B3GALT6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The enzyme encoded by this intronless gene is a beta-1,3-galactosyltransferase found in the medial Golgi apparatus, where it catalyzes the transfer of galactose from UDP-galactose to substrates containing a terminal beta-linked galactose moiety. The encoded enzyme has a particular affinity for galactose-beta-1,4-xylose found in the linker region of glycosamines. This enzyme is required for glycosaminoglycan synthesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.76494562
2maturation of SSU-rRNA (GO:0030490)5.07502505
3ribosomal small subunit assembly (GO:0000028)4.97509625
4outer ear morphogenesis (GO:0042473)4.85664450
5deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.72709823
6polyamine biosynthetic process (GO:0006596)4.57151074
7DNA strand elongation involved in DNA replication (GO:0006271)4.51604917
8low-density lipoprotein particle clearance (GO:0034383)4.49035707
9cochlea morphogenesis (GO:0090103)4.38091910
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.35628015
11viral transcription (GO:0019083)4.34296806
12DNA strand elongation (GO:0022616)4.31956148
13regulation of mammary gland epithelial cell proliferation (GO:0033599)4.27428452
14cotranslational protein targeting to membrane (GO:0006613)4.25720955
15adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.24743064
16translational termination (GO:0006415)4.22877617
17protein targeting to ER (GO:0045047)4.22714029
18telomere maintenance via semi-conservative replication (GO:0032201)4.17692520
19regulation of early endosome to late endosome transport (GO:2000641)4.15456447
20facial nerve structural organization (GO:0021612)4.12725101
21DNA unwinding involved in DNA replication (GO:0006268)4.12102811
22planar cell polarity pathway involved in neural tube closure (GO:0090179)4.03623818
23ribosomal small subunit biogenesis (GO:0042274)4.03495003
24establishment of protein localization to endoplasmic reticulum (GO:0072599)4.03234044
25diaphragm development (GO:0060539)4.00113697
26protein localization to endoplasmic reticulum (GO:0070972)3.99296831
27protein maturation by protein folding (GO:0022417)3.96321844
28DNA replication initiation (GO:0006270)3.86788279
29skeletal muscle organ development (GO:0060538)3.85000668
30translational elongation (GO:0006414)3.82872343
31protein localization to endosome (GO:0036010)3.79605137
32peptidyl-arginine omega-N-methylation (GO:0035247)3.76494831
33cell-cell junction maintenance (GO:0045217)3.69888222
34artery development (GO:0060840)3.66237503
35GMP metabolic process (GO:0046037)3.65187923
36response to pheromone (GO:0019236)3.64075797
37translational initiation (GO:0006413)3.60269949
382-deoxyribonucleotide biosynthetic process (GO:0009265)3.56468504
39deoxyribose phosphate biosynthetic process (GO:0046385)3.56468504
40ribosomal large subunit biogenesis (GO:0042273)3.55794093
41kidney mesenchyme development (GO:0072074)3.49248728
42regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.47831658
43folic acid-containing compound biosynthetic process (GO:0009396)3.45595318
44tRNA methylation (GO:0030488)3.41435021
45nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.40360112
46translation (GO:0006412)3.39925897
47peptidyl-arginine methylation (GO:0018216)3.39769103
48peptidyl-arginine N-methylation (GO:0035246)3.39769103
49formation of translation preinitiation complex (GO:0001731)3.38676479
50cellular protein complex disassembly (GO:0043624)3.37939193
51telomere maintenance via recombination (GO:0000722)3.36696723
52ribonucleoprotein complex biogenesis (GO:0022613)3.35132517
53viral life cycle (GO:0019058)3.34475332
54vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.31514711
55mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.27509407
56histone arginine methylation (GO:0034969)3.25907608
57translesion synthesis (GO:0019985)3.24640971
58skin morphogenesis (GO:0043589)3.23860951
59deoxyribonucleotide biosynthetic process (GO:0009263)3.22531688
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.21698569
61proteasome assembly (GO:0043248)3.21130289
62tooth mineralization (GO:0034505)3.19893004
63regulation of NFAT protein import into nucleus (GO:0051532)3.19378298
64nucleotide-excision repair, DNA gap filling (GO:0006297)3.18276177
65regulation of mitochondrial translation (GO:0070129)3.17796509
66negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.17066649
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.16128067
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.16128067
69DNA replication checkpoint (GO:0000076)3.15764423
70pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.14734244
71viral mRNA export from host cell nucleus (GO:0046784)3.13530282
72regulation of protein heterodimerization activity (GO:0043497)3.13407830
73dopamine receptor signaling pathway (GO:0007212)3.13353015
74pattern specification involved in kidney development (GO:0061004)3.13200728
75rRNA processing (GO:0006364)3.12182686
76guanosine-containing compound biosynthetic process (GO:1901070)3.12158968
77spliceosomal snRNP assembly (GO:0000387)3.11810773
78iron-sulfur cluster assembly (GO:0016226)3.11793775
79metallo-sulfur cluster assembly (GO:0031163)3.11793775
80negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.11181700
81energy coupled proton transport, down electrochemical gradient (GO:0015985)3.10055839
82ATP synthesis coupled proton transport (GO:0015986)3.10055839
83regulation of chromatin binding (GO:0035561)3.09984266
84protein complex biogenesis (GO:0070271)3.09834361
85nucleobase biosynthetic process (GO:0046112)3.09130440
86mitotic recombination (GO:0006312)3.08876663
87negative regulation of catenin import into nucleus (GO:0035414)3.08824293
88negative regulation of RNA splicing (GO:0033119)3.06631194
89lymph vessel development (GO:0001945)3.05178643
90telomere maintenance via telomere lengthening (GO:0010833)3.04994331
91pseudouridine synthesis (GO:0001522)3.04080910
92apoptotic process involved in morphogenesis (GO:0060561)3.03917057
93ribosome biogenesis (GO:0042254)3.03213223
94purine nucleobase biosynthetic process (GO:0009113)3.01865584
95regulation of apoptotic process involved in morphogenesis (GO:1902337)3.00302230
96postreplication repair (GO:0006301)2.99498233
97cellular component biogenesis (GO:0044085)2.99267806
98rRNA metabolic process (GO:0016072)2.99187597
99positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.98400053
100protein complex disassembly (GO:0043241)2.98294032
101positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.97846632
102negative regulation of fatty acid transport (GO:2000192)2.97470263
103mitochondrial respiratory chain complex assembly (GO:0033108)2.96594942
104de novo protein folding (GO:0006458)2.96590879
105macromolecular complex disassembly (GO:0032984)2.95204149
106pteridine-containing compound biosynthetic process (GO:0042559)2.94596912
107basement membrane organization (GO:0071711)2.94234869
108protein retention in ER lumen (GO:0006621)2.93921732
109exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93649003
110mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.92749072
111mitochondrial respiratory chain complex I assembly (GO:0032981)2.92749072
112NADH dehydrogenase complex assembly (GO:0010257)2.92749072
113protein targeting to mitochondrion (GO:0006626)2.92708178
114hyaluronan catabolic process (GO:0030214)2.92309842
115transcription elongation from RNA polymerase III promoter (GO:0006385)2.91817435
116termination of RNA polymerase III transcription (GO:0006386)2.91817435
117maternal placenta development (GO:0001893)2.90968792
118establishment of integrated proviral latency (GO:0075713)2.90893473
119negative regulation of erythrocyte differentiation (GO:0045647)2.90158544
120regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.89387263
121endothelial cell chemotaxis (GO:0035767)2.89208955
122pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.89060710
123negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87778152
124negative regulation of ligase activity (GO:0051352)2.87778152
125maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.87089922
126signal peptide processing (GO:0006465)2.86402966
127de novo posttranslational protein folding (GO:0051084)2.85934355
128establishment of protein localization to mitochondrion (GO:0072655)2.85360910
129nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.84994771
130dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.84478937
131COPI coating of Golgi vesicle (GO:0048205)2.84149308
132Golgi transport vesicle coating (GO:0048200)2.84149308
133negative regulation of cell size (GO:0045792)2.83965717
134modulation by symbiont of host cellular process (GO:0044068)2.83129650
135pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.83094514
136prepulse inhibition (GO:0060134)2.82718587
137camera-type eye morphogenesis (GO:0048593)2.82194202
138IMP biosynthetic process (GO:0006188)2.81956140
139anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.81409281
140heterochromatin organization (GO:0070828)2.81146921
141negative regulation of microtubule polymerization (GO:0031115)2.80495020
142protein insertion into membrane (GO:0051205)2.77690445
143G-protein coupled receptor internalization (GO:0002031)2.77326518
144proline biosynthetic process (GO:0006561)2.75539517
145regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.74428460
146regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.74428460
147mating behavior (GO:0007617)2.73263782
148metanephric mesenchyme development (GO:0072075)2.72313155
149cranial nerve structural organization (GO:0021604)2.71112588
150cardiovascular system development (GO:0072358)2.66601059
151establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.66092549
152mitochondrion transport along microtubule (GO:0047497)2.66092549
153mammary gland epithelial cell differentiation (GO:0060644)2.65221742
154activation of MAPKKK activity (GO:0000185)2.64566887
155semaphorin-plexin signaling pathway (GO:0071526)2.64189518
156adhesion of symbiont to host (GO:0044406)2.63732963
157icosanoid secretion (GO:0032309)2.62806907
158arachidonic acid secretion (GO:0050482)2.62806907
159snRNA metabolic process (GO:0016073)2.61401514
160virion attachment to host cell (GO:0019062)2.60361991
161adhesion of symbiont to host cell (GO:0044650)2.60361991
162adherens junction assembly (GO:0034333)2.59518324
163UV protection (GO:0009650)2.59040054
164post-embryonic morphogenesis (GO:0009886)2.58140431
165mannose metabolic process (GO:0006013)2.57750909
166embryonic skeletal joint morphogenesis (GO:0060272)2.56602523
167regulation of G0 to G1 transition (GO:0070316)2.51930537
168cell migration in hindbrain (GO:0021535)2.51387483
169convergent extension (GO:0060026)2.49981676
170positive regulation of protein dephosphorylation (GO:0035307)2.47843598
171aorta morphogenesis (GO:0035909)2.46297469
172apoptotic process involved in development (GO:1902742)2.46004881
173artery morphogenesis (GO:0048844)2.45447971
174modulation by virus of host process (GO:0019054)2.44772356
175Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.44732522
176regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.44254226
177positive regulation of axon extension (GO:0045773)2.43063618
178ear development (GO:0043583)2.41374652
179positive regulation of histone deacetylation (GO:0031065)2.39074823
180axon extension involved in axon guidance (GO:0048846)2.38652373
181neuron projection extension involved in neuron projection guidance (GO:1902284)2.38652373

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.36165191
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.93753300
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.59533477
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.77454408
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.69963576
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.57954350
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.35316602
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.34895613
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.22461945
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.10032096
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.96002428
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.95523332
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.81741354
14LXR_22292898_ChIP-Seq_THP-1_Human2.80136271
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.65805775
16* XRN2_22483619_ChIP-Seq_HELA_Human2.56809852
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.56454115
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.55616875
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.54005644
20VDR_23849224_ChIP-Seq_CD4+_Human2.45780931
21GABP_19822575_ChIP-Seq_HepG2_Human2.36584995
22DCP1A_22483619_ChIP-Seq_HELA_Human2.36488837
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.36124814
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35103184
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.32623343
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31662856
27* TTF2_22483619_ChIP-Seq_HELA_Human2.29398944
28TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.27963099
29KDM2B_26808549_Chip-Seq_SUP-B15_Human2.27153640
30RARG_19884340_ChIP-ChIP_MEFs_Mouse2.27107474
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.26296464
32TP63_17297297_ChIP-ChIP_HaCaT_Human2.23614087
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.20733076
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17272557
35* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.10852009
36* ZFX_18555785_ChIP-Seq_MESCs_Mouse2.10004734
37* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.09069163
38RACK7_27058665_Chip-Seq_MCF-7_Human2.08786725
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.07411378
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.05993348
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03919188
42ERG_21242973_ChIP-ChIP_JURKAT_Human2.00494187
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99547341
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.99325460
45FOXP3_21729870_ChIP-Seq_TREG_Human1.99303386
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96393470
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.94070564
48KDM2B_26808549_Chip-Seq_DND41_Human1.94044183
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93368838
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.89290144
51KDM2B_26808549_Chip-Seq_K562_Human1.89269278
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.83577751
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82016196
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.81983726
55EZH2_22144423_ChIP-Seq_EOC_Human1.80669067
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.79551857
57DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.78707908
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76580971
59* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.76317419
60ELK1_19687146_ChIP-ChIP_HELA_Human1.76267272
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75900153
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.72407466
63* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.72233415
64ZNF263_19887448_ChIP-Seq_K562_Human1.71075534
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.70989092
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.68477949
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.65057449
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.63913845
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.62999062
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62950596
71P68_20966046_ChIP-Seq_HELA_Human1.62273209
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58548489
73* SA1_27219007_Chip-Seq_ERYTHROID_Human1.58219543
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.57630093
75* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.57482083
76* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.52431530
77TCF7_22412390_ChIP-Seq_EML_Mouse1.51662850
78SRF_21415370_ChIP-Seq_HL-1_Mouse1.49906110
79MYC_22102868_ChIP-Seq_BL_Human1.48059486
80* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.46530569
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46390235
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44166546
83TP53_20018659_ChIP-ChIP_R1E_Mouse1.42422334
84HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41517862
85KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41439091
86MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41073013
87ELK1_22589737_ChIP-Seq_MCF10A_Human1.40999743
88CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40920685
89TP53_22127205_ChIP-Seq_IMR90_Human1.40795978
90SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.40407206
91DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38813188
92KDM2B_26808549_Chip-Seq_JURKAT_Human1.38792313
93MYC_18940864_ChIP-ChIP_HL60_Human1.36801334
94EGR1_19374776_ChIP-ChIP_THP-1_Human1.36309036
95CIITA_25753668_ChIP-Seq_RAJI_Human1.36076927
96MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35868670
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35215985
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.34951472
99CREB1_26743006_Chip-Seq_LNCaP_Human1.34830105
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.34335957
101CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34146073
102* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.32827672
103NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30841650
104POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30816870
105SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29091909
106P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27664498
107TFEB_21752829_ChIP-Seq_HELA_Human1.27024386
108SMC4_20622854_ChIP-Seq_HELA_Human1.26330303
109* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24886814
110RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24670637
111MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.23812876
112WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21099640
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20473545
114MAF_26560356_Chip-Seq_TH2_Human1.19955811
115SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.19908832
116* CTCF_27219007_Chip-Seq_Bcells_Human1.18030070
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17580948
118* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16457042
119ELF1_20517297_ChIP-Seq_JURKAT_Human1.16340357
120KDM5A_27292631_Chip-Seq_BREAST_Human1.16190700
121TRIM28_21343339_ChIP-Seq_HEK293_Human1.16144854
122NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15410329
123TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15025869
124VDR_24763502_ChIP-Seq_THP-1_Human1.14958405
125ESR2_21235772_ChIP-Seq_MCF-7_Human1.14160672
126AR_21909140_ChIP-Seq_LNCAP_Human1.13988752
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13864222
128KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13467634
129ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11583647
130UBF1/2_26484160_Chip-Seq_HMECs_Human1.10043220
131SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.09957112
132MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09585959
133CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08160330
134KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07708799
135SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07587985
136CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07473228
137CTCF_26484167_Chip-Seq_Bcells_Mouse1.06781368
138RARA_24833708_ChIP-Seq_LIVER_Mouse1.06753004
139MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05938190
140BCL6_27268052_Chip-Seq_Bcells_Human1.05665011
141CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02949632
142CTCF_21964334_Chip-Seq_Bcells_Human1.00995582
143ATF3_27146783_Chip-Seq_COLON_Human1.00961594
144STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.00757802
145SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00448973
146SMC3_22415368_ChIP-Seq_MEFs_Mouse0.99857305
147SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99753984
148FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99112554
149PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98809125
150VDR_21846776_ChIP-Seq_THP-1_Human0.97949093
151BCOR_27268052_Chip-Seq_Bcells_Human0.97744144
152OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96842645
153* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96596463
154NCOR1_26117541_ChIP-Seq_K562_Human0.96203102
155TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95710635
156HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95459198
157BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94717215
158KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94681727
159CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93193716
160ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92902647
161KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91593804
162CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91260390
163CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87203447
164HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84905104
165PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84887811
166FOXP1_21924763_ChIP-Seq_HESCs_Human0.83967358
167EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83805165
168SPI1_23547873_ChIP-Seq_NB4_Human0.76313646
169SOX2_18555785_ChIP-Seq_MESCs_Mouse0.76187046
170YY1_22570637_ChIP-Seq_MALME-3M_Human0.71277425
171FOXM1_23109430_ChIP-Seq_U2OS_Human0.70369686

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition6.46869648
2MP0003705_abnormal_hypodermis_morpholog5.01011986
3MP0003693_abnormal_embryo_hatching3.78289326
4MP0002877_abnormal_melanocyte_morpholog3.35110266
5MP0004858_abnormal_nervous_system2.98442157
6MP0003880_abnormal_central_pattern2.96638999
7MP0005058_abnormal_lysosome_morphology2.90214040
8MP0004957_abnormal_blastocyst_morpholog2.84164115
9MP0008438_abnormal_cutaneous_collagen2.79180226
10MP0003123_paternal_imprinting2.71415919
11MP0010094_abnormal_chromosome_stability2.63327969
12MP0003122_maternal_imprinting2.61239668
13MP0003111_abnormal_nucleus_morphology2.59886145
14MP0001529_abnormal_vocalization2.44596130
15MP0006292_abnormal_olfactory_placode2.44539742
16MP0009379_abnormal_foot_pigmentation2.34519345
17MP0009840_abnormal_foam_cell2.24032677
18MP0001849_ear_inflammation2.22243693
19MP0005257_abnormal_intraocular_pressure2.18476544
20MP0006276_abnormal_autonomic_nervous2.18252629
21MP0002638_abnormal_pupillary_reflex2.12439286
22MP0005623_abnormal_meninges_morphology2.10415047
23MP0002249_abnormal_larynx_morphology2.09997998
24MP0004185_abnormal_adipocyte_glucose2.07277392
25MP0008932_abnormal_embryonic_tissue2.04948630
26MP0008007_abnormal_cellular_replicative2.02771569
27MP0008789_abnormal_olfactory_epithelium2.02501946
28MP0001986_abnormal_taste_sensitivity2.02113116
29MP0005645_abnormal_hypothalamus_physiol2.01944227
30MP0009053_abnormal_anal_canal1.98784373
31MP0003942_abnormal_urinary_system1.92268383
32MP0005394_taste/olfaction_phenotype1.86739786
33MP0005499_abnormal_olfactory_system1.86739786
34MP0005076_abnormal_cell_differentiation1.85946008
35MP0004859_abnormal_synaptic_plasticity1.84202593
36MP0003077_abnormal_cell_cycle1.83805701
37MP0004272_abnormal_basement_membrane1.80947367
38MP0002102_abnormal_ear_morphology1.80447216
39MP0008058_abnormal_DNA_repair1.77261407
40MP0005423_abnormal_somatic_nervous1.74461322
41MP0009384_cardiac_valve_regurgitation1.72593164
42MP0003315_abnormal_perineum_morphology1.72230300
43MP0003279_aneurysm1.71571523
44MP0002751_abnormal_autonomic_nervous1.69464111
45MP0003303_peritoneal_inflammation1.67722687
46MP0006054_spinal_hemorrhage1.66373508
47MP0003121_genomic_imprinting1.63769450
48MP0003635_abnormal_synaptic_transmissio1.63194357
49MP0000733_abnormal_muscle_development1.61702855
50MP0002089_abnormal_postnatal_growth/wei1.60755641
51MP0000013_abnormal_adipose_tissue1.54759848
52MP0001188_hyperpigmentation1.52150547
53MP0003283_abnormal_digestive_organ1.51891885
54MP0002909_abnormal_adrenal_gland1.50789116
55MP0002396_abnormal_hematopoietic_system1.49422161
56MP0003329_amyloid_beta_deposits1.48615381
57MP0000750_abnormal_muscle_regeneration1.45552714
58MP0001968_abnormal_touch/_nociception1.42174289
59MP0003453_abnormal_keratinocyte_physiol1.42078982
60MP0002735_abnormal_chemical_nociception1.41958783
61MP0005084_abnormal_gallbladder_morpholo1.37764617
62MP0004510_myositis1.35416808
63MP0000534_abnormal_ureter_morphology1.30595917
64MP0000490_abnormal_crypts_of1.29052878
65MP0000631_abnormal_neuroendocrine_gland1.28022300
66MP0009250_abnormal_appendicular_skeleto1.27670067
67MP0003119_abnormal_digestive_system1.26283698
68MP0002184_abnormal_innervation1.25951032
69MP0002092_abnormal_eye_morphology1.25633316
70MP0003786_premature_aging1.25457437
71MP0002736_abnormal_nociception_after1.25326910
72MP0003091_abnormal_cell_migration1.24345325
73MP0001984_abnormal_olfaction1.23691794
74MP0009278_abnormal_bone_marrow1.20375650
75MP0002063_abnormal_learning/memory/cond1.19950839
76MP0005501_abnormal_skin_physiology1.19704451
77MP0008877_abnormal_DNA_methylation1.19339992
78MP0000049_abnormal_middle_ear1.18809182
79MP0000358_abnormal_cell_content/1.18691032
80MP0003566_abnormal_cell_adhesion1.18254049
81MP0000350_abnormal_cell_proliferation1.18106393
82MP0002234_abnormal_pharynx_morphology1.18103225
83MP0010368_abnormal_lymphatic_system1.17234874
84MP0004924_abnormal_behavior1.16682507
85MP0005386_behavior/neurological_phenoty1.16682507
86MP0005508_abnormal_skeleton_morphology1.16160177
87MP0006072_abnormal_retinal_apoptosis1.15881848
88MP0000767_abnormal_smooth_muscle1.15489833
89MP0000858_altered_metastatic_potential1.14878979
90MP0009333_abnormal_splenocyte_physiolog1.13646440
91MP0002557_abnormal_social/conspecific_i1.12040955
92MP0000681_abnormal_thyroid_gland1.10114302
93MP0002116_abnormal_craniofacial_bone1.10037593
94MP0001944_abnormal_pancreas_morphology1.09693626
95MP0001905_abnormal_dopamine_level1.09608836
96MP0002163_abnormal_gland_morphology1.09191075
97MP0005197_abnormal_uvea_morphology1.08227030
98MP0005220_abnormal_exocrine_pancreas1.06598230
99MP0010386_abnormal_urinary_bladder1.06385802
100MP0009672_abnormal_birth_weight1.02526460
101MP0000015_abnormal_ear_pigmentation1.02300452
102MP0005075_abnormal_melanosome_morpholog1.01566268
103MP0005503_abnormal_tendon_morphology1.00952139
104MP0000955_abnormal_spinal_cord1.00387061
105MP0001730_embryonic_growth_arrest1.00096054
106MP0002932_abnormal_joint_morphology0.98864204
107MP0002693_abnormal_pancreas_physiology0.98851794
108MP0002572_abnormal_emotion/affect_behav0.98658367
109MP0005174_abnormal_tail_pigmentation0.98520486
110MP0003938_abnormal_ear_development0.98157454
111MP0001542_abnormal_bone_strength0.98022237
112MP0002111_abnormal_tail_morphology0.97379672
113MP0001502_abnormal_circadian_rhythm0.97108821
114MP0000428_abnormal_craniofacial_morphol0.96132670
115MP0002896_abnormal_bone_mineralization0.96074135
116MP0003634_abnormal_glial_cell0.96067577
117MP0003763_abnormal_thymus_physiology0.96041180
118MP0001970_abnormal_pain_threshold0.94892102
119MP0009745_abnormal_behavioral_response0.92606754
120MP0002697_abnormal_eye_size0.92429666
121MP0000747_muscle_weakness0.92207199
122MP0004811_abnormal_neuron_physiology0.92057523
123MP0000343_altered_response_to0.91868412
124MP0003183_abnormal_peptide_metabolism0.91861782
125MP0002272_abnormal_nervous_system0.91415379
126MP0005193_abnormal_anterior_eye0.90659842
127MP0002064_seizures0.90302452
128MP0003755_abnormal_palate_morphology0.90230801
129MP0002113_abnormal_skeleton_development0.90150240
130MP0002080_prenatal_lethality0.89711677
131MP0002796_impaired_skin_barrier0.89222817
132MP0000678_abnormal_parathyroid_gland0.88923785
133MP0003385_abnormal_body_wall0.88019543
134MP0000604_amyloidosis0.87747029
135MP0003300_gastrointestinal_ulcer0.86849004
136MP0006035_abnormal_mitochondrial_morpho0.86663323
137MP0001958_emphysema0.85769322
138MP0002733_abnormal_thermal_nociception0.85310946
139MP0001440_abnormal_grooming_behavior0.85139451
140MP0002177_abnormal_outer_ear0.84856230
141MP0005379_endocrine/exocrine_gland_phen0.84185907
142MP0002095_abnormal_skin_pigmentation0.82035905
143MP0005666_abnormal_adipose_tissue0.80397575
144MP0006036_abnormal_mitochondrial_physio0.78946000
145MP0002067_abnormal_sensory_capabilities0.78732121
146MP0002734_abnormal_mechanical_nocicepti0.78633430
147MP0000778_abnormal_nervous_system0.78587482
148MP0010030_abnormal_orbit_morphology0.78447840
149MP0000537_abnormal_urethra_morphology0.78351945
150MP0000003_abnormal_adipose_tissue0.78308241
151MP0004134_abnormal_chest_morphology0.78033082
152MP0004808_abnormal_hematopoietic_stem0.77578156
153MP0005375_adipose_tissue_phenotype0.76924551
154MP0002114_abnormal_axial_skeleton0.76540676
155MP0000703_abnormal_thymus_morphology0.76240206
156MP0004142_abnormal_muscle_tone0.76180222
157MP0000372_irregular_coat_pigmentation0.76095226
158MP0002882_abnormal_neuron_morphology0.75791059
159MP0001697_abnormal_embryo_size0.75368041
160MP0000313_abnormal_cell_death0.75070823
161MP0003935_abnormal_craniofacial_develop0.74895189
162MP0000759_abnormal_skeletal_muscle0.74871381
163MP0000465_gastrointestinal_hemorrhage0.74320900
164MP0005595_abnormal_vascular_smooth0.74210964
165MP0001346_abnormal_lacrimal_gland0.73968788
166MP0003890_abnormal_embryonic-extraembry0.73590330
167MP0002085_abnormal_embryonic_tissue0.72507996
168MP0010307_abnormal_tumor_latency0.71405736
169MP0003861_abnormal_nervous_system0.70716563
170MP0004233_abnormal_muscle_weight0.70616531
171MP0004130_abnormal_muscle_cell0.69181848
172MP0002060_abnormal_skin_morphology0.68898665
173MP0003115_abnormal_respiratory_system0.65804134
174MP0005390_skeleton_phenotype0.64390356
175MP0003448_altered_tumor_morphology0.64087249
176MP0005023_abnormal_wound_healing0.63484210
177MP0000762_abnormal_tongue_morphology0.62587632
178MP0000163_abnormal_cartilage_morphology0.62506025
179MP0000432_abnormal_head_morphology0.62376133

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.36969973
2Abnormal number of erythroid precursors (HP:0012131)4.36463872
3Premature rupture of membranes (HP:0001788)4.05270961
4Protrusio acetabuli (HP:0003179)4.04711103
5Hyperacusis (HP:0010780)3.93336323
6Aplastic anemia (HP:0001915)3.66727622
7Achilles tendon contracture (HP:0001771)3.64200288
8Microvesicular hepatic steatosis (HP:0001414)3.52708969
9Hepatocellular necrosis (HP:0001404)3.41095107
10Abnormality of the anterior horn cell (HP:0006802)3.40421000
11Degeneration of anterior horn cells (HP:0002398)3.40421000
12Reticulocytopenia (HP:0001896)3.38200810
13Mitochondrial inheritance (HP:0001427)3.38104725
14Severe visual impairment (HP:0001141)3.31010988
15Genu recurvatum (HP:0002816)3.30007448
16Abnormality of liposaccharide metabolism (HP:0010968)3.26893051
17Abnormality of glycosphingolipid metabolism (HP:0004343)3.26893051
18Abnormality of glycolipid metabolism (HP:0010969)3.26893051
19Increased hepatocellular lipid droplets (HP:0006565)3.18122679
20Vertebral compression fractures (HP:0002953)3.16250010
21Ulnar bowing (HP:0003031)3.13522699
22Abnormality of the Achilles tendon (HP:0005109)3.12446423
23Rough bone trabeculation (HP:0100670)3.07198630
24Pallor (HP:0000980)3.05468543
25Type I transferrin isoform profile (HP:0003642)3.02059886
26Birth length less than 3rd percentile (HP:0003561)2.99728822
27Acute necrotizing encephalopathy (HP:0006965)2.96418344
28Unsteady gait (HP:0002317)2.95613188
29Broad metatarsal (HP:0001783)2.91328388
30Abnormal mitochondria in muscle tissue (HP:0008316)2.89895209
31Cerebral hypomyelination (HP:0006808)2.88083460
32Progressive muscle weakness (HP:0003323)2.86554929
33Lipid accumulation in hepatocytes (HP:0006561)2.85373691
34Cerebellar dysplasia (HP:0007033)2.84575497
35Increased CSF lactate (HP:0002490)2.78602079
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.74851121
37Poor head control (HP:0002421)2.72421856
38Thoracic kyphosis (HP:0002942)2.72016637
39Turricephaly (HP:0000262)2.71407873
40Disproportionate tall stature (HP:0001519)2.70584014
41Supernumerary nipples (HP:0002558)2.69420126
42Atrophy/Degeneration involving motor neurons (HP:0007373)2.67683476
43Hypoplasia of the pons (HP:0012110)2.66840837
44Hepatic necrosis (HP:0002605)2.65330989
45Abnormal protein glycosylation (HP:0012346)2.62735914
46Abnormal glycosylation (HP:0012345)2.62735914
47Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.62735914
48Abnormal protein N-linked glycosylation (HP:0012347)2.62735914
49Microretrognathia (HP:0000308)2.61629029
50Truncus arteriosus (HP:0001660)2.59584732
51Irregular epiphyses (HP:0010582)2.57977661
52Biconcave vertebral bodies (HP:0004586)2.52844783
53Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.52491255
54Decreased activity of mitochondrial respiratory chain (HP:0008972)2.52491255
55Mesangial abnormality (HP:0001966)2.52315861
56Type II lissencephaly (HP:0007260)2.51056850
57Visual hallucinations (HP:0002367)2.46029056
58Emotional lability (HP:0000712)2.45493485
59Increased serum lactate (HP:0002151)2.45466348
60Breast hypoplasia (HP:0003187)2.42765040
61Absent rod-and cone-mediated responses on ERG (HP:0007688)2.42314531
62Macrocytic anemia (HP:0001972)2.42276147
63Abnormality of the thoracic spine (HP:0100711)2.42219657
64Limb-girdle muscle atrophy (HP:0003797)2.41980914
65* Fragile skin (HP:0001030)2.39801637
66Renal duplication (HP:0000075)2.39218974
67Hyperparathyroidism (HP:0000843)2.39209102
68Bladder diverticulum (HP:0000015)2.38995907
69* Broad distal phalanx of finger (HP:0009836)2.36197869
70Back pain (HP:0003418)2.36045635
71Thoracolumbar scoliosis (HP:0002944)2.34300654
72Cerebral inclusion bodies (HP:0100314)2.32253375
73Neurofibrillary tangles (HP:0002185)2.31180332
74Exertional dyspnea (HP:0002875)2.30721442
75Atrophic scars (HP:0001075)2.30672372
76Insomnia (HP:0100785)2.30615709
77Abnormality of the phalanges of the hallux (HP:0010057)2.30410034
78Shallow orbits (HP:0000586)2.29983388
79* Mitral regurgitation (HP:0001653)2.29153221
80Spinal rigidity (HP:0003306)2.28870688
81Abnormality of dentin (HP:0010299)2.25814766
82Long palpebral fissure (HP:0000637)2.25136436
83Oral leukoplakia (HP:0002745)2.24758520
84Patellar dislocation (HP:0002999)2.23572207
85Cerebral aneurysm (HP:0004944)2.23489220
86Abnormal trabecular bone morphology (HP:0100671)2.22148066
87Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.22008368
88Shoulder girdle muscle weakness (HP:0003547)2.21670756
89Abnormality of the pons (HP:0007361)2.20976092
90Progressive macrocephaly (HP:0004481)2.18908370
91Increased intramyocellular lipid droplets (HP:0012240)2.18767717
92Carpal bone hypoplasia (HP:0001498)2.18343995
93Postnatal microcephaly (HP:0005484)2.18313569
94* Blue sclerae (HP:0000592)2.17514050
95Hyperthyroidism (HP:0000836)2.17285545
96Congenital glaucoma (HP:0001087)2.16872973
97Dysostosis multiplex (HP:0000943)2.13009655
98Deep palmar crease (HP:0006191)2.06311998
99Exercise intolerance (HP:0003546)2.04648759
100Increased cerebral lipofuscin (HP:0011813)2.04622844
101Difficulty climbing stairs (HP:0003551)2.04527904
102Lactic acidosis (HP:0003128)2.04379841
103* Spinal cord compression (HP:0002176)2.03393213
104Poor suck (HP:0002033)2.03347631
105Personality changes (HP:0000751)2.02969259
106Elfin facies (HP:0004428)2.02759135
107Overriding aorta (HP:0002623)2.01924257
108Renal Fanconi syndrome (HP:0001994)2.01430555
109Abnormality of alanine metabolism (HP:0010916)2.01080326
110Hyperalaninemia (HP:0003348)2.01080326
111Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01080326
112Selective tooth agenesis (HP:0001592)2.00357247
113Pointed chin (HP:0000307)2.00294906
114Lissencephaly (HP:0001339)2.00124536
115Pelvic girdle muscle weakness (HP:0003749)1.99936060
116Aplasia/Hypoplasia of the sacrum (HP:0008517)1.99788898
117Thin bony cortex (HP:0002753)1.98422525
118Hypercalcemia (HP:0003072)1.97975426
119Obstructive sleep apnea (HP:0002870)1.97740012
120Broad face (HP:0000283)1.97222301
121Partial duplication of the phalanx of hand (HP:0009999)1.95640431
122Upper motor neuron abnormality (HP:0002127)1.94743314
123Abnormality of the heme biosynthetic pathway (HP:0010472)1.94682167
124Abnormality of the aortic arch (HP:0012303)1.92627871
125Mitral valve prolapse (HP:0001634)1.92216295
126Premature graying of hair (HP:0002216)1.91985266
127* Slender long bone (HP:0003100)1.91899734
128Partial duplication of thumb phalanx (HP:0009944)1.91897182
129Delusions (HP:0000746)1.91896021
130Respiratory failure (HP:0002878)1.91376497
131Ankle contracture (HP:0006466)1.90609022
132Abnormal ventriculo-arterial connection (HP:0011563)1.90142469
133Transposition of the great arteries (HP:0001669)1.90142469
134Abnormal connection of the cardiac segments (HP:0011545)1.90142469
135Respiratory difficulties (HP:0002880)1.88058683
136Nuclear cataract (HP:0100018)1.87896165
137Nonimmune hydrops fetalis (HP:0001790)1.87613776
138Trismus (HP:0000211)1.87459270
139Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.87235796
140Glossoptosis (HP:0000162)1.86709402
141Abnormal rod and cone electroretinograms (HP:0008323)1.85682282
142Acute encephalopathy (HP:0006846)1.84999782
143Abnormality of the distal phalanx of the thumb (HP:0009617)1.84362550
144Pancreatic fibrosis (HP:0100732)1.80672402
145Multiple lipomas (HP:0001012)1.80044212
146Elbow flexion contracture (HP:0002987)1.79799653
147Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.79578526
148Annular pancreas (HP:0001734)1.79370346
149Sleep apnea (HP:0010535)1.79026403
150Increased neuronal autofluorescent lipopigment (HP:0002074)1.77709486
151Diminished motivation (HP:0000745)1.77617341
152Limb dystonia (HP:0002451)1.77533883
153Abnormality of the musculature of the pelvis (HP:0001469)1.77274813
154Abnormality of the hip-girdle musculature (HP:0001445)1.77274813
155Arnold-Chiari malformation (HP:0002308)1.76682034
156Axonal loss (HP:0003447)1.75898974
157Reduced antithrombin III activity (HP:0001976)1.74747336
158* Deviation of the hallux (HP:0010051)1.74739621
159Long toe (HP:0010511)1.74470846
160Horseshoe kidney (HP:0000085)1.74061709
161Coxa vara (HP:0002812)1.73989858
162Failure to thrive in infancy (HP:0001531)1.72824975
163Increased muscle lipid content (HP:0009058)1.71890775
164Pancreatic cysts (HP:0001737)1.70622750
165Megalocornea (HP:0000485)1.70366030
166Hypercortisolism (HP:0001578)1.69835027
167* Hyperextensible skin (HP:0000974)1.69826606
168Abnormality of the acetabulum (HP:0003170)1.69689008
169Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69412576
170Dilatation of the ascending aorta (HP:0005111)1.69338777
171Absent epiphyses (HP:0010577)1.68911446
172Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.68911446
173Lumbar hyperlordosis (HP:0002938)1.68570098
174* Bowed forearm bones (HP:0003956)1.68145316
175* Bowing of the arm (HP:0006488)1.68145316
176* Hallux valgus (HP:0001822)1.67949641
177Long eyelashes (HP:0000527)1.67227316
178Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.67221966
179Abnormality of the distal phalanges of the toes (HP:0010182)1.67091414
180Aortic regurgitation (HP:0001659)1.66142986
181Muscle fiber atrophy (HP:0100295)1.65858748
182Neonatal short-limb short stature (HP:0008921)1.65576294
183Apathy (HP:0000741)1.65493291
184Renovascular hypertension (HP:0100817)1.65343891
185Depressed nasal ridge (HP:0000457)1.65307700
186Abnormal number of incisors (HP:0011064)1.65239054
187Increased connective tissue (HP:0009025)1.65008068
188Venous abnormality (HP:0002624)1.64799110
189Papilledema (HP:0001085)1.64724649
190Abnormal large intestine physiology (HP:0012700)1.64044789
191Hyperphosphaturia (HP:0003109)1.63916281
192Cervical subluxation (HP:0003308)1.63326919
193True hermaphroditism (HP:0010459)1.62985386
194Congenital stationary night blindness (HP:0007642)1.62809473
195Self-mutilation (HP:0000742)1.62030350

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.42333221
2STK164.37272366
3IRAK34.07919782
4SCYL23.53494596
5WEE12.93653591
6CDC72.82919825
7ICK2.82358824
8SMG12.80952654
9PRPF4B2.66866742
10MAP3K122.40994077
11TAOK22.34125388
12SIK12.31951473
13BUB12.30902391
14PASK2.23803700
15NME22.21811161
16VRK12.21611546
17CAMKK22.17622647
18TNIK2.09398119
19TLK12.03710109
20EEF2K2.02187410
21BRSK21.99232873
22ERN11.96665860
23EIF2AK11.94925158
24CCNB11.94638402
25CAMK1D1.91202931
26PIM21.85400307
27SRPK11.85314359
28TESK21.84111099
29PRKD31.79104703
30NTRK31.77201763
31DYRK31.74103008
32BRSK11.70662313
33EIF2AK31.68612865
34MAP3K111.67463450
35MINK11.64914986
36MAP2K71.60182681
37RIPK11.59971724
38DAPK11.54152664
39MARK11.53459710
40SIK21.52737823
41NME11.47856042
42CDK81.46537588
43CDK191.46478802
44IRAK21.45575174
45NTRK11.43191023
46KSR21.42211934
47DDR21.28076761
48TSSK61.27829684
49MAP2K31.26034142
50CAMK1G1.24873888
51MKNK21.22870805
52MAPK151.20422381
53RAF11.20358024
54TTN1.20087203
55RPS6KA41.18750505
56TYRO31.16294834
57AURKA1.14700416
58PDGFRA1.13136209
59MKNK11.10779571
60MAPK131.09220151
61ARAF1.07023428
62RPS6KB21.05165677
63PRKD21.04723402
64DYRK21.03349465
65PKN21.03264139
66KSR11.02730536
67CDK121.02537831
68MTOR1.02285535
69LATS21.00164140
70TAOK10.99517870
71MAP3K80.98824740
72MAP3K40.96557769
73PTK20.96459153
74CDK40.96437098
75PTK60.95196807
76EPHA20.95024624
77MAP3K10.94030966
78MARK20.93746570
79KDR0.93696786
80MOS0.93467709
81ACVR1B0.92403594
82HIPK20.92152371
83FLT30.91969285
84RPS6KA20.91073178
85UHMK10.90182138
86PLK10.89356015
87BRAF0.89070771
88CAMKK10.88888512
89PLK30.87337605
90PNCK0.83974772
91DYRK1A0.83597428
92ADRBK20.81158051
93ERBB30.78427091
94CDK70.77527008
95RPS6KL10.76752775
96RPS6KC10.76752775
97YES10.76436458
98PAK20.76326189
99PLK20.75926694
100CHEK20.75616281
101CDC42BPA0.74905015
102TESK10.74823605
103CDK140.73490735
104WNK30.73388702
105FES0.71686665
106LRRK20.69393767
107MAP3K100.68607429
108MAP3K30.68148313
109CSNK1G30.66666963
110PAK60.65964318
111TIE10.64530260
112MAP3K20.63654186
113DAPK30.62152640
114ATR0.61685217
115PRKCH0.60690690
116RPS6KA60.58793031
117NTRK20.58630422
118MAPKAPK30.57933423
119NEK20.57097831
120NEK10.56869931
121CSNK1G20.56823966
122MAP3K90.56009305
123NEK90.55887821
124PRKCG0.53117188
125AURKB0.53116123
126CDK180.52971253
127ILK0.52579902
128IRAK40.51627814
129LIMK10.51512659
130CSNK2A20.51021957
131PDPK10.50997254
132CDK11A0.50856921
133PAK40.50403447
134CDK150.49792170
135TAOK30.49772081
136CSNK2A10.48763392
137EPHA40.48433631
138TGFBR10.48333810
139CAMK10.44418716
140PLK40.43733667
141RPS6KA50.42992343
142MAPKAPK50.42847154
143RET0.41955255
144SYK0.41810453
145EPHB20.41001095
146CHEK10.40828953
147RPS6KA10.39949987
148ZAP700.39408510
149TEC0.37957399
150AKT20.37109019
151DYRK1B0.36607891
152ZAK0.35875978
153MAPK40.35875511
154ABL20.35319902
155CDK50.33352317
156TBK10.31933740
157MAPK110.31842044
158NLK0.31630037
159VRK20.30474695
160WNK10.30149466
161BMX0.29247549
162MAP2K20.27261494
163BCKDK0.26670812

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.32490458
2Ribosome_Homo sapiens_hsa030103.76659663
3Proteasome_Homo sapiens_hsa030503.28412588
4Protein export_Homo sapiens_hsa030603.05026788
5Mismatch repair_Homo sapiens_hsa034303.03831939
6RNA polymerase_Homo sapiens_hsa030202.44344086
7Spliceosome_Homo sapiens_hsa030402.41153110
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38277145
9Homologous recombination_Homo sapiens_hsa034402.31085684
10Prion diseases_Homo sapiens_hsa050202.28129550
11Base excision repair_Homo sapiens_hsa034102.18100252
12Chronic myeloid leukemia_Homo sapiens_hsa052202.16968378
13Notch signaling pathway_Homo sapiens_hsa043302.11990294
14* Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.10967313
15Pyrimidine metabolism_Homo sapiens_hsa002402.10623308
16Oxidative phosphorylation_Homo sapiens_hsa001902.08143407
17Parkinsons disease_Homo sapiens_hsa050122.03808172
18Nucleotide excision repair_Homo sapiens_hsa034202.02139237
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.97983329
20N-Glycan biosynthesis_Homo sapiens_hsa005101.86712211
21RNA transport_Homo sapiens_hsa030131.85620169
22Acute myeloid leukemia_Homo sapiens_hsa052211.81434901
23VEGF signaling pathway_Homo sapiens_hsa043701.73395883
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.70581561
25Cell cycle_Homo sapiens_hsa041101.65810960
26Lysosome_Homo sapiens_hsa041421.59778391
27Non-small cell lung cancer_Homo sapiens_hsa052231.58280509
28Pancreatic cancer_Homo sapiens_hsa052121.56391745
29Huntingtons disease_Homo sapiens_hsa050161.53624882
30One carbon pool by folate_Homo sapiens_hsa006701.45332251
31Alzheimers disease_Homo sapiens_hsa050101.41467177
32Endometrial cancer_Homo sapiens_hsa052131.37609144
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35628116
34Glioma_Homo sapiens_hsa052141.32895718
35Neurotrophin signaling pathway_Homo sapiens_hsa047221.30078514
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29200785
37Renal cell carcinoma_Homo sapiens_hsa052111.27185364
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.26288487
39RNA degradation_Homo sapiens_hsa030181.25383689
40Selenocompound metabolism_Homo sapiens_hsa004501.25344241
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.24528609
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24235372
43Synaptic vesicle cycle_Homo sapiens_hsa047211.22344979
44ErbB signaling pathway_Homo sapiens_hsa040121.21350983
45Fanconi anemia pathway_Homo sapiens_hsa034601.21027552
46Vibrio cholerae infection_Homo sapiens_hsa051101.20507243
47Basal cell carcinoma_Homo sapiens_hsa052171.19020040
48Nicotine addiction_Homo sapiens_hsa050331.17199356
49Melanoma_Homo sapiens_hsa052181.14047832
50Alcoholism_Homo sapiens_hsa050341.13831530
51Purine metabolism_Homo sapiens_hsa002301.13691264
52Sulfur relay system_Homo sapiens_hsa041221.09957632
53Small cell lung cancer_Homo sapiens_hsa052221.06510527
54TNF signaling pathway_Homo sapiens_hsa046681.05085156
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04476546
56Salmonella infection_Homo sapiens_hsa051321.03487322
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02819634
58Thyroid cancer_Homo sapiens_hsa052161.01646539
59B cell receptor signaling pathway_Homo sapiens_hsa046621.01497234
60* Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99501740
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98865396
62Oocyte meiosis_Homo sapiens_hsa041140.96882410
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95995805
64MicroRNAs in cancer_Homo sapiens_hsa052060.95062250
65mTOR signaling pathway_Homo sapiens_hsa041500.94891405
66ECM-receptor interaction_Homo sapiens_hsa045120.93439967
67Focal adhesion_Homo sapiens_hsa045100.93276440
68Amoebiasis_Homo sapiens_hsa051460.93055616
69Apoptosis_Homo sapiens_hsa042100.92486458
70Other glycan degradation_Homo sapiens_hsa005110.91403552
71Hippo signaling pathway_Homo sapiens_hsa043900.90271269
72Long-term potentiation_Homo sapiens_hsa047200.89936018
73Proteoglycans in cancer_Homo sapiens_hsa052050.89649447
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89317303
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88295642
76Folate biosynthesis_Homo sapiens_hsa007900.88093294
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87505520
78Prostate cancer_Homo sapiens_hsa052150.86904963
79Osteoclast differentiation_Homo sapiens_hsa043800.85614065
80Amphetamine addiction_Homo sapiens_hsa050310.85309603
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.83298925
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82819531
83Basal transcription factors_Homo sapiens_hsa030220.82618140
84Axon guidance_Homo sapiens_hsa043600.82242289
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80352896
86Dopaminergic synapse_Homo sapiens_hsa047280.79972410
87Phototransduction_Homo sapiens_hsa047440.79936900
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78906720
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78856856
90Insulin secretion_Homo sapiens_hsa049110.78673716
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76834182
92Olfactory transduction_Homo sapiens_hsa047400.75357552
93Cocaine addiction_Homo sapiens_hsa050300.72611545
94Insulin signaling pathway_Homo sapiens_hsa049100.72565702
95Systemic lupus erythematosus_Homo sapiens_hsa053220.72531971
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72202999
97Circadian entrainment_Homo sapiens_hsa047130.71641168
98Estrogen signaling pathway_Homo sapiens_hsa049150.71313237
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.71154061
100p53 signaling pathway_Homo sapiens_hsa041150.70405566
101Pathways in cancer_Homo sapiens_hsa052000.70313754
102Non-homologous end-joining_Homo sapiens_hsa034500.69375895
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68707868
104Prolactin signaling pathway_Homo sapiens_hsa049170.67668937
105Rap1 signaling pathway_Homo sapiens_hsa040150.66604128
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66322300
107Epstein-Barr virus infection_Homo sapiens_hsa051690.66185337
108Malaria_Homo sapiens_hsa051440.65053276
109mRNA surveillance pathway_Homo sapiens_hsa030150.64963475
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.63861787
111AMPK signaling pathway_Homo sapiens_hsa041520.63340379
112Cardiac muscle contraction_Homo sapiens_hsa042600.61941173
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61611987
114MAPK signaling pathway_Homo sapiens_hsa040100.61286516
115Endocytosis_Homo sapiens_hsa041440.61124475
116Hedgehog signaling pathway_Homo sapiens_hsa043400.60796219
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60442552
118GnRH signaling pathway_Homo sapiens_hsa049120.60398500
119Biosynthesis of amino acids_Homo sapiens_hsa012300.54790861
120Colorectal cancer_Homo sapiens_hsa052100.53779314
121Hepatitis C_Homo sapiens_hsa051600.53016660
122Fructose and mannose metabolism_Homo sapiens_hsa000510.52573771
123Pentose phosphate pathway_Homo sapiens_hsa000300.52350645
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51614171
125Gap junction_Homo sapiens_hsa045400.51531017
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51420646
127GABAergic synapse_Homo sapiens_hsa047270.50785013
128Dilated cardiomyopathy_Homo sapiens_hsa054140.50741399
129Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49984095
130Serotonergic synapse_Homo sapiens_hsa047260.49034252
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48877054
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48616840
133Viral carcinogenesis_Homo sapiens_hsa052030.47628122
134Cholinergic synapse_Homo sapiens_hsa047250.47393867
135Galactose metabolism_Homo sapiens_hsa000520.47056887
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45417406
137Bladder cancer_Homo sapiens_hsa052190.44981219
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44715969
139Taste transduction_Homo sapiens_hsa047420.43868740
140HIF-1 signaling pathway_Homo sapiens_hsa040660.43792995
141Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43606169
142Tuberculosis_Homo sapiens_hsa051520.43372879
143Glutamatergic synapse_Homo sapiens_hsa047240.43199128
144Wnt signaling pathway_Homo sapiens_hsa043100.41013771
145Morphine addiction_Homo sapiens_hsa050320.40191778
146HTLV-I infection_Homo sapiens_hsa051660.39223684
147Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37341325
148Long-term depression_Homo sapiens_hsa047300.35520651
149Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33019807
150Regulation of autophagy_Homo sapiens_hsa041400.32576219
151Shigellosis_Homo sapiens_hsa051310.31049575
152Glycosaminoglycan degradation_Homo sapiens_hsa005310.30868350
153Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29991094
154Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29165652
155Type I diabetes mellitus_Homo sapiens_hsa049400.29080658
156Cysteine and methionine metabolism_Homo sapiens_hsa002700.29041209
157Hepatitis B_Homo sapiens_hsa051610.28386101
158Collecting duct acid secretion_Homo sapiens_hsa049660.27821645
159Melanogenesis_Homo sapiens_hsa049160.26762651
160Central carbon metabolism in cancer_Homo sapiens_hsa052300.26751583
161Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25977741
162Pancreatic secretion_Homo sapiens_hsa049720.25593393
163Phagosome_Homo sapiens_hsa041450.25485065
164Antigen processing and presentation_Homo sapiens_hsa046120.24953019
165* Metabolic pathways_Homo sapiens_hsa011000.23355094
166Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22906491

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