B3GALT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene is expressed exclusively in the brain. The encoded protein shows strict donor substrate specificity for UDP-galactose. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of smooth muscle cell differentiation (GO:0051151)8.27155977
2positive regulation of fatty acid beta-oxidation (GO:0032000)5.18709647
3platelet dense granule organization (GO:0060155)4.97180532
4meiotic chromosome segregation (GO:0045132)4.93140880
5behavioral response to nicotine (GO:0035095)4.86739523
6vocalization behavior (GO:0071625)4.78075159
7neuron cell-cell adhesion (GO:0007158)4.76205966
8positive regulation of fatty acid oxidation (GO:0046321)4.62055947
9DNA strand renaturation (GO:0000733)4.54788935
10synaptic vesicle exocytosis (GO:0016079)4.40858086
11male sex determination (GO:0030238)4.39769974
12glutamate secretion (GO:0014047)4.37054790
13regulation of nuclear cell cycle DNA replication (GO:0033262)4.35358706
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.32361635
15regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)4.27611077
16regulation of short-term neuronal synaptic plasticity (GO:0048172)4.21863679
17neurotransmitter-gated ion channel clustering (GO:0072578)4.15512549
18aldehyde catabolic process (GO:0046185)4.03144334
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.01367572
20inner mitochondrial membrane organization (GO:0007007)3.99804356
21neuronal action potential propagation (GO:0019227)3.98062795
22protein localization to synapse (GO:0035418)3.95890400
23presynaptic membrane assembly (GO:0097105)3.94408852
24protein import into peroxisome matrix (GO:0016558)3.92479233
25regulation of glutamate receptor signaling pathway (GO:1900449)3.90564620
26regulation of histone phosphorylation (GO:0033127)3.90101269
27negative regulation of DNA-dependent DNA replication (GO:2000104)3.86678223
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.84946468
29response to pheromone (GO:0019236)3.84509977
30negative regulation of dendrite morphogenesis (GO:0050774)3.75092660
31locomotory exploration behavior (GO:0035641)3.74792530
32negative regulation of histone methylation (GO:0031061)3.74468311
33regulation of synaptic vesicle exocytosis (GO:2000300)3.72519551
34ionotropic glutamate receptor signaling pathway (GO:0035235)3.71171880
35exploration behavior (GO:0035640)3.67742465
36neurotransmitter secretion (GO:0007269)3.67486682
37pyrimidine nucleobase catabolic process (GO:0006208)3.61349656
38synaptic vesicle docking involved in exocytosis (GO:0016081)3.57368095
39synaptic vesicle maturation (GO:0016188)3.55482941
40presynaptic membrane organization (GO:0097090)3.54463518
41glutamate receptor signaling pathway (GO:0007215)3.53102767
42negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.52977344
43negative regulation of translation, ncRNA-mediated (GO:0040033)3.52977344
44regulation of translation, ncRNA-mediated (GO:0045974)3.52977344
45gamma-aminobutyric acid transport (GO:0015812)3.50329291
46regulation of smooth muscle cell differentiation (GO:0051150)3.42612622
47neuron-neuron synaptic transmission (GO:0007270)3.40233259
48neuron recognition (GO:0008038)3.39041572
49replication fork processing (GO:0031297)3.38611872
50cell migration in hindbrain (GO:0021535)3.38517915
51negative regulation of dendrite development (GO:2000171)3.37822698
52postsynaptic membrane organization (GO:0001941)3.36413394
53negative regulation of synaptic transmission, GABAergic (GO:0032229)3.33790826
54regulation of synaptic vesicle transport (GO:1902803)3.33122881
55synaptic transmission, glutamatergic (GO:0035249)3.32409392
56positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.31822651
57proteasome assembly (GO:0043248)3.31519429
58regulation of neuronal synaptic plasticity (GO:0048168)3.28015129
59histone-serine phosphorylation (GO:0035404)3.23344445
60oxidative phosphorylation (GO:0006119)3.21753185
61nucleobase catabolic process (GO:0046113)3.18781596
62dopamine transport (GO:0015872)3.18238705
63inositol metabolic process (GO:0006020)3.14483661
64cerebellar granule cell differentiation (GO:0021707)3.13762913
65regulation of long-term neuronal synaptic plasticity (GO:0048169)3.13661057
66innervation (GO:0060384)3.13081816
67ribosomal small subunit assembly (GO:0000028)3.10743415
68protein neddylation (GO:0045116)3.10342869
69protein complex biogenesis (GO:0070271)3.10044912
70negative regulation of telomere maintenance (GO:0032205)3.10028671
71erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.07063973
72L-phenylalanine catabolic process (GO:0006559)3.07063973
73neurotransmitter transport (GO:0006836)3.06866983
74membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.06448357
75positive regulation of neurotransmitter secretion (GO:0001956)3.05205295
76regulation of excitatory postsynaptic membrane potential (GO:0060079)3.04857988
77regulation of synapse structural plasticity (GO:0051823)3.04740367
78gamma-aminobutyric acid signaling pathway (GO:0007214)3.04410276
79behavioral response to cocaine (GO:0048148)3.04254487
80intracellular protein transmembrane import (GO:0044743)3.03066996
81outer ear morphogenesis (GO:0042473)3.02127918
82DNA replication checkpoint (GO:0000076)2.99887539
83L-serine metabolic process (GO:0006563)2.99620633
84regulation of neurotransmitter levels (GO:0001505)2.97638005
85regulation of glutamate secretion (GO:0014048)2.97491786
86cysteine metabolic process (GO:0006534)2.95766351
87DNA double-strand break processing (GO:0000729)2.95398728
88L-fucose catabolic process (GO:0042355)2.94905298
89fucose catabolic process (GO:0019317)2.94905298
90L-fucose metabolic process (GO:0042354)2.94905298
91regulation of appetite (GO:0032098)2.93315900
92response to histamine (GO:0034776)2.92422044
93axonal fasciculation (GO:0007413)2.92373454
94regulation of synaptic transmission, glutamatergic (GO:0051966)2.92034765
95regulation of postsynaptic membrane potential (GO:0060078)2.91649673
96catecholamine transport (GO:0051937)2.91497796
97mitochondrial respiratory chain complex assembly (GO:0033108)2.90937084
98transmission of nerve impulse (GO:0019226)2.90806978
99bile acid and bile salt transport (GO:0015721)2.90042705
100positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.89075875
101long-term synaptic potentiation (GO:0060291)2.88871037
102regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.87740987
103detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.87431397
104positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.86826918
105mitochondrial respiratory chain complex I assembly (GO:0032981)2.86450382
106NADH dehydrogenase complex assembly (GO:0010257)2.86450382
107mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.86450382
108synapsis (GO:0007129)2.85475323
109synapse assembly (GO:0007416)2.84417648
110suckling behavior (GO:0001967)2.83892346
111epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.83571777
112reciprocal DNA recombination (GO:0035825)2.83415467
113reciprocal meiotic recombination (GO:0007131)2.83415467
114indole-containing compound catabolic process (GO:0042436)2.82937976
115indolalkylamine catabolic process (GO:0046218)2.82937976
116tryptophan catabolic process (GO:0006569)2.82937976
117auditory behavior (GO:0031223)2.81928400
118nucleotide transmembrane transport (GO:1901679)2.81909641
119nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.81210761
120peroxisome fission (GO:0016559)2.79905240
121anterograde synaptic vesicle transport (GO:0048490)2.79895376
122sequestering of actin monomers (GO:0042989)2.79373496
123somite rostral/caudal axis specification (GO:0032525)2.79294505
124exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.78791465
125regulation of telomerase activity (GO:0051972)2.77863726
126prenylation (GO:0097354)2.76804227
127protein prenylation (GO:0018342)2.76804227
128G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.76492366
129proline transport (GO:0015824)2.76187883
130erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.75855561
131L-phenylalanine metabolic process (GO:0006558)2.75855561
132regulation of synaptic plasticity (GO:0048167)2.75581154
133telomere maintenance via telomerase (GO:0007004)2.75430539
134negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.74260029
135mechanosensory behavior (GO:0007638)2.74243108
136negative regulation of peptidyl-lysine acetylation (GO:2000757)2.73448609
137lysine metabolic process (GO:0006553)2.72566183
138lysine catabolic process (GO:0006554)2.72566183
139protein targeting to peroxisome (GO:0006625)2.72127633
140establishment of protein localization to peroxisome (GO:0072663)2.72127633
141protein localization to peroxisome (GO:0072662)2.72127633
142negative regulation of histone acetylation (GO:0035067)2.72055611
143regulation of helicase activity (GO:0051095)2.71922102
144cytochrome complex assembly (GO:0017004)2.71197861
145somatic hypermutation of immunoglobulin genes (GO:0016446)2.70826293
146somatic diversification of immune receptors via somatic mutation (GO:0002566)2.70826293
147intracellular protein transmembrane transport (GO:0065002)2.70413885
148lung-associated mesenchyme development (GO:0060484)2.69609616
149positive regulation of synapse maturation (GO:0090129)2.69552711
150positive regulation of membrane potential (GO:0045838)2.69541719
151cellular ketone body metabolic process (GO:0046950)2.69361343
152phosphatidylinositol acyl-chain remodeling (GO:0036149)2.68993961
153regulation of female receptivity (GO:0045924)2.68560741
154left/right pattern formation (GO:0060972)2.67611482
155regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.67295891
156prepulse inhibition (GO:0060134)2.67251146
157atrial cardiac muscle cell action potential (GO:0086014)2.66509547
158regulation of neurotransmitter secretion (GO:0046928)2.65916537
159positive regulation of synapse assembly (GO:0051965)2.65594700
160cellular response to pH (GO:0071467)2.65296291
161regulation of dendritic spine morphogenesis (GO:0061001)2.65266146
162regulation of telomere maintenance (GO:0032204)2.65033461
163hindbrain development (GO:0030902)2.64776854
164cerebellar Purkinje cell differentiation (GO:0021702)2.64741448
165female mating behavior (GO:0060180)2.64144484
166RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.63806206
167negative regulation of telomerase activity (GO:0051974)2.63461803
168negative regulation of neurotransmitter transport (GO:0051589)2.63217399
169synaptic vesicle endocytosis (GO:0048488)2.63185977
170calcium-mediated signaling using intracellular calcium source (GO:0035584)2.62509486
171membrane depolarization (GO:0051899)2.59097837
172neurofilament cytoskeleton organization (GO:0060052)2.58908449
173regulation of vesicle fusion (GO:0031338)2.58646801
174dendritic spine morphogenesis (GO:0060997)2.58096846
175somite development (GO:0061053)2.57821952
176membrane depolarization during action potential (GO:0086010)2.57434897
177limb bud formation (GO:0060174)2.57159284
178layer formation in cerebral cortex (GO:0021819)2.56885503
179spinal cord motor neuron differentiation (GO:0021522)2.55878008
180neuromuscular process controlling posture (GO:0050884)2.54645533
181response to auditory stimulus (GO:0010996)2.54142413
182dendrite morphogenesis (GO:0048813)2.53536183
183regulation of mitochondrial translation (GO:0070129)2.53488358
184epithelial cilium movement (GO:0003351)2.53384570
185positive regulation of triglyceride biosynthetic process (GO:0010867)2.52075429
186regulation of neurotransmitter transport (GO:0051588)2.50926931
187aromatic amino acid family catabolic process (GO:0009074)2.50814545
188learning (GO:0007612)2.50330606
189long-term memory (GO:0007616)2.50267167
190coenzyme catabolic process (GO:0009109)2.49337315
191behavioral fear response (GO:0001662)2.49099572
192behavioral defense response (GO:0002209)2.49099572
193startle response (GO:0001964)2.47785753
194synaptic transmission (GO:0007268)2.47238718
195synapse organization (GO:0050808)2.45725837

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.65792024
2GBX2_23144817_ChIP-Seq_PC3_Human4.06558291
3MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.91773780
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.91489332
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.88115457
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.83082587
7TAF15_26573619_Chip-Seq_HEK293_Human2.81250097
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.72369410
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39702286
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.39057844
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.37554254
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.37554254
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.36516336
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34856252
15* REST_21632747_ChIP-Seq_MESCs_Mouse2.32072095
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31370421
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27683168
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.25537227
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.22702532
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.21258518
21POU5F1_16153702_ChIP-ChIP_HESCs_Human2.18589728
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18300438
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18013465
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16959310
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.16318534
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.15782360
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.15161729
28CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13533202
29SALL1_21062744_ChIP-ChIP_HESCs_Human2.11628192
30EWS_26573619_Chip-Seq_HEK293_Human2.08968487
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06736606
32CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06078789
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99987869
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.89680270
35MYC_18940864_ChIP-ChIP_HL60_Human1.89481277
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88650372
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.85155295
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.84606239
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84575431
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.84203417
41RARB_27405468_Chip-Seq_BRAIN_Mouse1.83372708
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.83217361
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82502027
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.79027715
45SMAD4_21799915_ChIP-Seq_A2780_Human1.78965617
46* P300_19829295_ChIP-Seq_ESCs_Human1.78074271
47ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.76378306
48* AR_21572438_ChIP-Seq_LNCaP_Human1.74277828
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.73079905
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67923830
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.67887278
52DROSHA_22980978_ChIP-Seq_HELA_Human1.67232195
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63644748
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63366264
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61491708
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.59225235
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56557492
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.56126877
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52444368
60* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52208605
61* SOX2_19829295_ChIP-Seq_ESCs_Human1.50275492
62* NANOG_19829295_ChIP-Seq_ESCs_Human1.50275492
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.49644243
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49338887
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49214983
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.48950639
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45439702
68ELK1_19687146_ChIP-ChIP_HELA_Human1.43748223
69* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43485466
70SOX2_16153702_ChIP-ChIP_HESCs_Human1.42312894
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39995458
72VDR_22108803_ChIP-Seq_LS180_Human1.39798293
73* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39676614
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.39641025
75* AR_25329375_ChIP-Seq_VCAP_Human1.38734273
76NANOG_16153702_ChIP-ChIP_HESCs_Human1.37028680
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.36758610
78CBP_20019798_ChIP-Seq_JUKART_Human1.33657253
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33657253
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33615758
81IGF1R_20145208_ChIP-Seq_DFB_Human1.33390155
82IRF1_19129219_ChIP-ChIP_H3396_Human1.33296772
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32719966
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.32303047
85ZNF274_21170338_ChIP-Seq_K562_Hela1.32148962
86SOX2_21211035_ChIP-Seq_LN229_Gbm1.31834234
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.31480700
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28677748
89STAT3_23295773_ChIP-Seq_U87_Human1.27714188
90FUS_26573619_Chip-Seq_HEK293_Human1.25708390
91* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23596794
92FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21604970
93FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21396621
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.21396621
95TP53_22573176_ChIP-Seq_HFKS_Human1.20004713
96RNF2_27304074_Chip-Seq_NSC_Mouse1.19283622
97BCAT_22108803_ChIP-Seq_LS180_Human1.19029443
98CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18896604
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.18531167
100* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17026668
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15935344
102IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12196818
103NCOR_22424771_ChIP-Seq_293T_Human1.11672302
104CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.11348307
105* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11347446
106VDR_23849224_ChIP-Seq_CD4+_Human1.11288146
107ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11154122
108AHR_22903824_ChIP-Seq_MCF-7_Human1.10668395
109LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10121594
110* TCF4_23295773_ChIP-Seq_U87_Human1.10082726
111* RUNX2_22187159_ChIP-Seq_PCA_Human1.09778860
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09584393
113RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09316720
114FLI1_21867929_ChIP-Seq_TH2_Mouse1.08744352
115CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08715441
116MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08670197
117ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08528256
118NFE2_27457419_Chip-Seq_LIVER_Mouse1.08285974
119* PRDM14_20953172_ChIP-Seq_ESCs_Human1.08261364
120RXR_22158963_ChIP-Seq_LIVER_Mouse1.08073407
121KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07968252
122JUN_21703547_ChIP-Seq_K562_Human1.07189334
123PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07049934
124* AR_19668381_ChIP-Seq_PC3_Human1.06235093
125FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05057559
126SRF_21415370_ChIP-Seq_HL-1_Mouse1.04938502
127NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04762877
128TP53_18474530_ChIP-ChIP_U2OS_Human1.04728430
129RING1B_27294783_Chip-Seq_ESCs_Mouse1.03942754
130ER_23166858_ChIP-Seq_MCF-7_Human1.02971265
131GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02934254
132SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.02585907
133NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01983862
134* NANOG_18555785_Chip-Seq_ESCs_Mouse1.01518380
135ETS1_20019798_ChIP-Seq_JURKAT_Human1.01131793
136* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00499077
137TCF4_22108803_ChIP-Seq_LS180_Human1.00077116
138* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00003986
139CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99485895
140MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98814585
141P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98132161
142GATA3_21878914_ChIP-Seq_MCF-7_Human0.98023128
143RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97865024
144CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97025148
145TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96374512
146TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96366584
147POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96366584
148TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96360414
149PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95126422
150CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94795946
151KDM2B_26808549_Chip-Seq_REH_Human0.94661939
152HTT_18923047_ChIP-ChIP_STHdh_Human0.94398180
153STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94098066
154SMAD_19615063_ChIP-ChIP_OVARY_Human0.93919148
155NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93472902
156NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93472902
157BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92160993
158* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91050976
159SMAD4_21741376_ChIP-Seq_EPCs_Human0.90839570
160SOX9_26525672_Chip-Seq_HEART_Mouse0.90499837

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.04202536
2MP0004859_abnormal_synaptic_plasticity4.54873394
3MP0003283_abnormal_digestive_organ3.91309042
4MP0004270_analgesia3.55125953
5MP0003635_abnormal_synaptic_transmissio3.42676749
6MP0009745_abnormal_behavioral_response3.02881316
7MP0003011_delayed_dark_adaptation2.94627989
8MP0002063_abnormal_learning/memory/cond2.86007256
9MP0002139_abnormal_hepatobiliary_system2.85290279
10MP0001968_abnormal_touch/_nociception2.81922164
11MP0002064_seizures2.77505799
12MP0009046_muscle_twitch2.75620661
13MP0002735_abnormal_chemical_nociception2.74541675
14MP0002822_catalepsy2.63644188
15MP0002102_abnormal_ear_morphology2.63470415
16MP0004133_heterotaxia2.58556801
17MP0002736_abnormal_nociception_after2.56839241
18MP0006276_abnormal_autonomic_nervous2.55815351
19MP0002572_abnormal_emotion/affect_behav2.55722913
20MP0002734_abnormal_mechanical_nocicepti2.47456053
21MP0002272_abnormal_nervous_system2.35446729
22MP0001486_abnormal_startle_reflex2.35224445
23MP0003136_yellow_coat_color2.29741466
24MP0008877_abnormal_DNA_methylation2.19512745
25MP0003941_abnormal_skin_development2.15147833
26MP0005423_abnormal_somatic_nervous2.14608086
27MP0005085_abnormal_gallbladder_physiolo2.09535831
28MP0001440_abnormal_grooming_behavior2.09112072
29MP0002938_white_spotting2.06174113
30MP0001529_abnormal_vocalization2.03990124
31MP0005360_urolithiasis2.03478675
32MP0000566_synostosis2.02924984
33MP0002733_abnormal_thermal_nociception2.00276842
34MP0002067_abnormal_sensory_capabilities1.96574598
35MP0001501_abnormal_sleep_pattern1.93921147
36MP0003693_abnormal_embryo_hatching1.90004140
37MP0003329_amyloid_beta_deposits1.88800611
38MP0000778_abnormal_nervous_system1.88795070
39MP0005253_abnormal_eye_physiology1.87653561
40MP0003646_muscle_fatigue1.84326724
41MP0003890_abnormal_embryonic-extraembry1.80870015
42MP0006072_abnormal_retinal_apoptosis1.79073846
43MP0002277_abnormal_respiratory_mucosa1.77018346
44MP0001970_abnormal_pain_threshold1.75465711
45MP0002184_abnormal_innervation1.74236314
46MP0008875_abnormal_xenobiotic_pharmacok1.73728030
47MP0004858_abnormal_nervous_system1.72373604
48MP0003567_abnormal_fetal_cardiomyocyte1.71790701
49MP0004924_abnormal_behavior1.70683475
50MP0005386_behavior/neurological_phenoty1.70683475
51MP0001905_abnormal_dopamine_level1.67342557
52MP0005646_abnormal_pituitary_gland1.66118395
53MP0005365_abnormal_bile_salt1.61698869
54MP0009780_abnormal_chondrocyte_physiolo1.61311742
55MP0006292_abnormal_olfactory_placode1.60722972
56MP0001984_abnormal_olfaction1.58493766
57MP0008058_abnormal_DNA_repair1.58131838
58MP0002557_abnormal_social/conspecific_i1.53959940
59MP0003937_abnormal_limbs/digits/tail_de1.52796383
60MP0000569_abnormal_digit_pigmentation1.51439134
61MP0004142_abnormal_muscle_tone1.48715481
62MP0004147_increased_porphyrin_level1.46541984
63MP0002638_abnormal_pupillary_reflex1.45826380
64MP0000955_abnormal_spinal_cord1.44922590
65MP0004130_abnormal_muscle_cell1.43091675
66MP0003137_abnormal_impulse_conducting1.41002302
67MP0008569_lethality_at_weaning1.40080286
68MP0002876_abnormal_thyroid_physiology1.37416427
69MP0004811_abnormal_neuron_physiology1.37092326
70MP0003879_abnormal_hair_cell1.35381581
71MP0001293_anophthalmia1.33292983
72MP0002837_dystrophic_cardiac_calcinosis1.30173752
73MP0002653_abnormal_ependyma_morphology1.28619698
74MP0008961_abnormal_basal_metabolism1.27828389
75MP0002066_abnormal_motor_capabilities/c1.27237109
76MP0003718_maternal_effect1.26756002
77MP0000647_abnormal_sebaceous_gland1.26600358
78MP0002882_abnormal_neuron_morphology1.25826881
79MP0004043_abnormal_pH_regulation1.25087665
80MP0000383_abnormal_hair_follicle1.23896221
81MP0001188_hyperpigmentation1.23828383
82MP0004215_abnormal_myocardial_fiber1.23671761
83MP0001502_abnormal_circadian_rhythm1.22514115
84MP0003119_abnormal_digestive_system1.21495030
85MP0003633_abnormal_nervous_system1.18849461
86MP0001286_abnormal_eye_development1.15804709
87MP0002282_abnormal_trachea_morphology1.15663965
88MP0010329_abnormal_lipoprotein_level1.14596566
89MP0005448_abnormal_energy_balance1.12976303
90MP0002909_abnormal_adrenal_gland1.10927079
91MP0001929_abnormal_gametogenesis1.09858328
92MP0000604_amyloidosis1.09586735
93MP0005535_abnormal_body_temperature1.09039882
94MP0008057_abnormal_DNA_replication1.08266597
95MP0003631_nervous_system_phenotype1.07731285
96MP0004019_abnormal_vitamin_homeostasis1.06167399
97MP0002229_neurodegeneration1.03840243
98MP0002210_abnormal_sex_determination1.03396701
99MP0004885_abnormal_endolymph1.03185730
100MP0008995_early_reproductive_senescence1.01700434
101MP0005551_abnormal_eye_electrophysiolog1.01350159
102MP0005195_abnormal_posterior_eye1.00115995
103MP0008872_abnormal_physiological_respon0.99034182
104MP0003111_abnormal_nucleus_morphology0.98659104
105MP0009379_abnormal_foot_pigmentation0.97420320
106MP0005391_vision/eye_phenotype0.95220978
107MP0000653_abnormal_sex_gland0.94393107
108MP0010094_abnormal_chromosome_stability0.93905784
109MP0005645_abnormal_hypothalamus_physiol0.92498048
110MP0008874_decreased_physiological_sensi0.91722195
111MP0004742_abnormal_vestibular_system0.91073815
112MP0001324_abnormal_eye_pigmentation0.90875758
113MP0004957_abnormal_blastocyst_morpholog0.90843868
114MP0002152_abnormal_brain_morphology0.90813167
115MP0005083_abnormal_biliary_tract0.89732702
116MP0003122_maternal_imprinting0.89567166
117MP0002069_abnormal_eating/drinking_beha0.89439313
118MP0003861_abnormal_nervous_system0.89260400
119MP0000751_myopathy0.88766147
120MP0008932_abnormal_embryonic_tissue0.88127043
121MP0008007_abnormal_cellular_replicative0.87284870
122MP0001963_abnormal_hearing_physiology0.87172020
123MP0003690_abnormal_glial_cell0.86601646
124MP0003755_abnormal_palate_morphology0.86483582
125MP0004085_abnormal_heartbeat0.86367264
126MP0001145_abnormal_male_reproductive0.84506366
127MP0000427_abnormal_hair_cycle0.83560739
128MP0005332_abnormal_amino_acid0.82559466
129MP0003632_abnormal_nervous_system0.82450829
130MP0003698_abnormal_male_reproductive0.81327263
131MP0003868_abnormal_feces_composition0.80934268
132MP0002234_abnormal_pharynx_morphology0.79530550
133MP0002752_abnormal_somatic_nervous0.79512467
134MP0001177_atelectasis0.78891783
135MP0000049_abnormal_middle_ear0.78746970
136MP0000920_abnormal_myelination0.77935065
137MP0003195_calcinosis0.74777282
138MP0003634_abnormal_glial_cell0.74256593
139MP0002751_abnormal_autonomic_nervous0.67629216
140MP0004145_abnormal_muscle_electrophysio0.67044430
141MP0005409_darkened_coat_color0.67035914
142MP0003252_abnormal_bile_duct0.65408903
143MP0001664_abnormal_digestion0.65092638
144MP0003787_abnormal_imprinting0.65029491
145MP0002090_abnormal_vision0.64711250
146MP0002118_abnormal_lipid_homeostasis0.63116605
147MP0009697_abnormal_copulation0.62909789
148MP0000639_abnormal_adrenal_gland0.62245470
149MP0005171_absent_coat_pigmentation0.61445046
150MP0010386_abnormal_urinary_bladder0.61149842
151MP0000631_abnormal_neuroendocrine_gland0.58451530
152MP0001485_abnormal_pinna_reflex0.57986567
153MP0000026_abnormal_inner_ear0.57955336
154MP0001986_abnormal_taste_sensitivity0.56739961
155MP0005584_abnormal_enzyme/coenzyme_acti0.56663931
156MP0006035_abnormal_mitochondrial_morpho0.54037303
157MP0005187_abnormal_penis_morphology0.53681049

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.75311135
2Myokymia (HP:0002411)5.70621355
3Hyperventilation (HP:0002883)4.78612815
4Birth length less than 3rd percentile (HP:0003561)4.77186699
5Focal seizures (HP:0007359)4.76602215
6Atonic seizures (HP:0010819)4.46858530
7Epileptic encephalopathy (HP:0200134)4.31601237
8Febrile seizures (HP:0002373)4.19879888
9Renal cortical cysts (HP:0000803)4.14242075
10Colon cancer (HP:0003003)3.87213271
11Absence seizures (HP:0002121)3.72745909
12Progressive cerebellar ataxia (HP:0002073)3.71113580
13Visual hallucinations (HP:0002367)3.62627467
14Large for gestational age (HP:0001520)3.56004185
15Pheochromocytoma (HP:0002666)3.55188887
16Dialeptic seizures (HP:0011146)3.52447201
17Generalized tonic-clonic seizures (HP:0002069)3.48074104
18Action tremor (HP:0002345)3.47790057
19Turricephaly (HP:0000262)3.47222698
20Abnormal number of erythroid precursors (HP:0012131)3.38579011
21Pendular nystagmus (HP:0012043)3.36033101
22Abnormality of the renal cortex (HP:0011035)3.34509505
23Brushfield spots (HP:0001088)3.32132949
24Neuroendocrine neoplasm (HP:0100634)3.15716535
25Type II lissencephaly (HP:0007260)3.04141007
26Abnormality of the labia minora (HP:0012880)2.97282788
27Abnormality of midbrain morphology (HP:0002418)2.96471737
28Molar tooth sign on MRI (HP:0002419)2.96471737
29Amblyopia (HP:0000646)2.93990687
30Congenital, generalized hypertrichosis (HP:0004540)2.93793020
31Abnormality of aromatic amino acid family metabolism (HP:0004338)2.91383915
32Impaired vibration sensation in the lower limbs (HP:0002166)2.86612371
33Termporal pattern (HP:0011008)2.83558839
34Insidious onset (HP:0003587)2.83558839
35Abnormality of cells of the erythroid lineage (HP:0012130)2.81437598
36Broad-based gait (HP:0002136)2.81435337
37Limb dystonia (HP:0002451)2.81279182
38Supranuclear gaze palsy (HP:0000605)2.78987065
39Pancreatic cysts (HP:0001737)2.75933648
40Abnormality of the corticospinal tract (HP:0002492)2.75449513
41Gaze-evoked nystagmus (HP:0000640)2.75364960
42Patellar aplasia (HP:0006443)2.72462474
43Deep venous thrombosis (HP:0002625)2.72116088
44Decreased central vision (HP:0007663)2.68683728
45Anxiety (HP:0000739)2.67426774
46Epileptiform EEG discharges (HP:0011182)2.65508095
47Cerebral inclusion bodies (HP:0100314)2.63847466
48Scanning speech (HP:0002168)2.62874765
49True hermaphroditism (HP:0010459)2.62324295
50Prolonged partial thromboplastin time (HP:0003645)2.59494346
51Tubulointerstitial nephritis (HP:0001970)2.59128393
52Neurofibrillary tangles (HP:0002185)2.57569507
53Hyperglycinuria (HP:0003108)2.57250915
54Truncal ataxia (HP:0002078)2.56061984
55Pancreatic fibrosis (HP:0100732)2.54941180
56Bell-shaped thorax (HP:0001591)2.54595199
57Flat occiput (HP:0005469)2.53004037
58Status epilepticus (HP:0002133)2.52910562
59Intestinal atresia (HP:0011100)2.52801110
60Dysdiadochokinesis (HP:0002075)2.52459122
61Lissencephaly (HP:0001339)2.51858403
62Spontaneous abortion (HP:0005268)2.51627072
63Abnormal social behavior (HP:0012433)2.49157025
64Impaired social interactions (HP:0000735)2.49157025
65Excessive salivation (HP:0003781)2.47021849
66Drooling (HP:0002307)2.47021849
67Aplasia/Hypoplasia of the patella (HP:0006498)2.46861054
68Spastic gait (HP:0002064)2.45416229
69EEG with generalized epileptiform discharges (HP:0011198)2.44807023
70Hyperlipoproteinemia (HP:0010980)2.43527194
71Hypoplastic ischia (HP:0003175)2.43175947
72Hypothermia (HP:0002045)2.41600075
73Fetal akinesia sequence (HP:0001989)2.41279758
74Dysmetria (HP:0001310)2.39860926
75Poor eye contact (HP:0000817)2.39767258
76Urinary bladder sphincter dysfunction (HP:0002839)2.38154360
77Delusions (HP:0000746)2.36939673
78Blue irides (HP:0000635)2.35768798
79Degeneration of the lateral corticospinal tracts (HP:0002314)2.34242221
80Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.34242221
81Intrahepatic cholestasis (HP:0001406)2.33983047
82Depression (HP:0000716)2.33719799
83Torticollis (HP:0000473)2.33230941
84Clitoromegaly (HP:0000057)2.31757742
85Hypsarrhythmia (HP:0002521)2.29724667
86Hypobetalipoproteinemia (HP:0003563)2.28023870
87Ankle clonus (HP:0011448)2.27689895
88Abnormal eating behavior (HP:0100738)2.27271550
89Supernumerary spleens (HP:0009799)2.27251563
90Focal dystonia (HP:0004373)2.26215311
91Cerebellar dysplasia (HP:0007033)2.25207946
92Female pseudohermaphroditism (HP:0010458)2.24701517
93Abnormality of serine family amino acid metabolism (HP:0010894)2.23603149
94Abnormality of glycine metabolism (HP:0010895)2.23603149
95Optic disc pallor (HP:0000543)2.23193126
96Impaired vibratory sensation (HP:0002495)2.22245618
97Polymicrogyria (HP:0002126)2.21975216
98Intellectual disability, progressive (HP:0006887)2.21526914
99Complement deficiency (HP:0004431)2.21063522
100Abnormality of the lower motor neuron (HP:0002366)2.20635746
101Poor suck (HP:0002033)2.18170628
102Craniofacial dystonia (HP:0012179)2.16804483
103Breast hypoplasia (HP:0003187)2.16495655
104Absent speech (HP:0001344)2.14556525
105Urinary urgency (HP:0000012)2.13101714
106Infantile muscular hypotonia (HP:0008947)2.12554143
107Progressive inability to walk (HP:0002505)2.11012637
108Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.10430183
109Polyphagia (HP:0002591)2.10214206
110Abnormality of the ischium (HP:0003174)2.09691599
111Xanthomatosis (HP:0000991)2.09525778
112Abnormality of the pons (HP:0007361)2.09430122
113Generalized myoclonic seizures (HP:0002123)2.06862279
114Cystic liver disease (HP:0006706)2.06830915
115Bradykinesia (HP:0002067)2.05735996
116Fair hair (HP:0002286)2.05662906
117Abnormal biliary tract physiology (HP:0012439)2.04430619
118Bile duct proliferation (HP:0001408)2.04430619
119Bifid tongue (HP:0010297)2.03447098
120Furrowed tongue (HP:0000221)2.03278236
121Inability to walk (HP:0002540)2.03176754
122Clumsiness (HP:0002312)2.02723098
123Morphological abnormality of the pyramidal tract (HP:0002062)2.01514722
124Thyroid-stimulating hormone excess (HP:0002925)2.00856590
125Epidermoid cyst (HP:0200040)2.00361274
126Absent septum pellucidum (HP:0001331)2.00134659
127Akinesia (HP:0002304)1.99804318
128Abnormal gallbladder physiology (HP:0012438)1.99611522
129Cholecystitis (HP:0001082)1.99611522
130Abnormality of alanine metabolism (HP:0010916)1.97751373
131Hyperalaninemia (HP:0003348)1.97751373
132Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97751373
133Bilateral microphthalmos (HP:0007633)1.97354325
134Lower limb muscle weakness (HP:0007340)1.96486320
135Breech presentation (HP:0001623)1.96388976
136Retinal dysplasia (HP:0007973)1.96182819
137Increased serum pyruvate (HP:0003542)1.95545967
138Abnormality of glycolysis (HP:0004366)1.95545967
139Abnormality of the septum pellucidum (HP:0007375)1.95542731
140Cerebral hemorrhage (HP:0001342)1.94808652
141Dysmetric saccades (HP:0000641)1.93963743
142Global brain atrophy (HP:0002283)1.93794859
143Hemiparesis (HP:0001269)1.93610215
144Abnormality of the renal medulla (HP:0100957)1.91726181
145Chronic sinusitis (HP:0011109)1.90780707
146Neoplasm of the peripheral nervous system (HP:0100007)1.89744833
147Gait imbalance (HP:0002141)1.88907358
148Protruding tongue (HP:0010808)1.88666909
149Septo-optic dysplasia (HP:0100842)1.87907426
150Postural instability (HP:0002172)1.87212868
151Ulnar claw (HP:0001178)1.86069110
152Conjugated hyperbilirubinemia (HP:0002908)1.85906659
153Acute encephalopathy (HP:0006846)1.85715405
154Abnormality of the clitoris (HP:0000056)1.85494931
155Acute necrotizing encephalopathy (HP:0006965)1.84619834
156Dandy-Walker malformation (HP:0001305)1.84550546
157Leukodystrophy (HP:0002415)1.84105983
158Adrenal hypoplasia (HP:0000835)1.84058878
159Anophthalmia (HP:0000528)1.83655226
160Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.82961172
161Abnormality of serum amino acid levels (HP:0003112)1.81698458
162Hypoplasia of the pons (HP:0012110)1.80608546
163Preaxial foot polydactyly (HP:0001841)1.78892105
164Nephroblastoma (Wilms tumor) (HP:0002667)1.77258368
165Prominent supraorbital ridges (HP:0000336)1.76944083
166Absent/shortened dynein arms (HP:0200106)1.76650130
167Dynein arm defect of respiratory motile cilia (HP:0012255)1.76650130
168Genetic anticipation (HP:0003743)1.75878040
169Abnormality of monocarboxylic acid metabolism (HP:0010996)1.75753790
170Progressive macrocephaly (HP:0004481)1.75339312
171Embryonal renal neoplasm (HP:0011794)1.74101413
172Hyperglycinemia (HP:0002154)1.73885338
173Widely patent fontanelles and sutures (HP:0004492)1.73770817
174Cerebral edema (HP:0002181)1.73471760
175Incomplete penetrance (HP:0003829)1.72454971
176Gastrointestinal atresia (HP:0002589)1.71848230
177Abnormal biliary tract morphology (HP:0012440)1.71213963
178Abnormal mitochondria in muscle tissue (HP:0008316)1.70851483
179Metabolic alkalosis (HP:0200114)1.69787473
180Abnormality of the phalanges of the 2nd finger (HP:0009541)1.69398461
181Attenuation of retinal blood vessels (HP:0007843)1.68591972
182Hypoplasia of the capital femoral epiphysis (HP:0003090)1.67938042
183Partial duplication of the phalanx of hand (HP:0009999)1.66843448
184Median cleft lip (HP:0000161)1.66447070
185Spastic tetraparesis (HP:0001285)1.65330874
186Abnormality of the line of Schwalbe (HP:0008048)1.64837881
187Posterior embryotoxon (HP:0000627)1.64758829
188Optic nerve hypoplasia (HP:0000609)1.64723059
189Abnormality of chloride homeostasis (HP:0011422)1.64120173

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.81640503
2NTRK34.35114238
3EPHA43.84857834
4VRK23.21752716
5MAP3K42.96284703
6MARK12.91913015
7MAP2K72.79276009
8NUAK12.73580342
9MAP3K122.73516946
10MINK12.65405882
11MAP3K92.58899893
12TAF12.45212359
13MAP2K42.32057744
14DAPK22.16829775
15BRSK22.03150785
16MKNK21.95198894
17PLK21.84794969
18MAPK131.78605779
19CDK191.74350260
20KSR11.61343901
21BUB11.60951627
22PRPF4B1.60335582
23ERBB31.57894943
24TRIM281.50966067
25BMPR1B1.50228668
26PAK61.48431446
27SIK31.46689852
28NTRK11.46265628
29SGK4941.44494263
30SGK2231.44494263
31NTRK21.44455491
32FRK1.44038179
33VRK11.42661434
34ARAF1.42487009
35SGK21.42023038
36MKNK11.39415889
37ACVR1B1.38790489
38PNCK1.38664786
39KSR21.38447200
40GRK51.37735839
41DAPK11.36044171
42OXSR11.34162153
43PRKCG1.28829423
44CDK51.27176996
45PLK31.26527979
46RIPK41.25414869
47TSSK61.24362702
48STK38L1.22868787
49ZAK1.21299906
50CAMK2A1.20760305
51MET1.20425769
52AKT31.19109006
53NEK91.18390130
54PLK41.16241763
55GRK11.11866059
56WEE11.10956581
57PHKG11.09893037
58PHKG21.09893037
59NLK1.09854675
60BCR1.09217615
61MAP4K21.07508264
62CAMK2B1.05493581
63TNIK1.03079549
64ADRBK20.99899232
65ERBB40.97839501
66SIK20.96237486
67BMPR20.94243552
68SGK30.91466167
69CAMKK10.90877929
70TGFBR10.90458845
71LATS20.87651100
72CSNK1G10.86566180
73PTK2B0.86540078
74CAMK1D0.86129129
75CSNK1G20.85214887
76MAP3K20.83759264
77UHMK10.83440670
78CDK180.81427356
79PASK0.80812511
80LATS10.80740056
81CAMK2G0.80286972
82CAMKK20.79246425
83NME10.79109955
84CSNK1A1L0.76359418
85CDC70.76250012
86CDK140.73071268
87CDK150.72929903
88PIK3CA0.71281471
89STK390.71191176
90TTK0.70254013
91DYRK20.69630530
92RET0.68994064
93DYRK1A0.68940411
94FGR0.68469939
95PLK10.68291743
96BRSK10.68082314
97LMTK20.67306190
98PBK0.67279930
99GRK70.66554050
100MAPKAPK50.66496034
101NEK10.65744897
102PAK30.65522484
103MAP2K10.65304607
104PRKCE0.63962275
105RAF10.62351210
106FES0.61096449
107SGK10.60880408
108CAMK2D0.60404864
109CDK11A0.59859401
110MUSK0.58069122
111BRAF0.57610779
112DYRK30.56780823
113MAP2K20.54441900
114MAP3K130.53944412
115MAPK120.53812451
116CCNB10.53775338
117PRKCH0.53469767
118PRKCZ0.52385484
119MELK0.51980257
120PKN10.51947678
121CSNK1G30.51905575
122STK110.51895101
123CAMK1G0.51480451
124PINK10.50735527
125FGFR20.49573449
126ADRBK10.49031618
127PDGFRB0.48240127
128INSRR0.46224904
129BMX0.45909305
130FER0.45290831
131WNK40.44128680
132RPS6KA50.43446298
133WNK10.42908838
134ROCK20.42600731
135PDPK10.42083236
136RPS6KA20.41661931
137PRKACA0.41479369
138RPS6KA30.39363708
139CAMK10.38543628
140PRKAA20.38027180
141STK380.37367116
142EPHB20.37238161
143WNK30.37066682
144TYRO30.36488623
145PDK10.35533870
146ERBB20.34381095
147MAPK150.34371432
148LIMK10.34313636
149EPHB10.34286606
150PRKG10.34027146
151PRKACB0.33608264
152OBSCN0.33462237
153CSF1R0.31483341
154SMG10.30279527
155MAP3K100.25743340
156ATR0.25333253
157EIF2AK20.25187052
158SRPK10.23765376
159STK30.23727969
160IGF1R0.22386797
161TIE10.21633158
162IRAK20.20999015
163IRAK40.19903328

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.39400230
2Synaptic vesicle cycle_Homo sapiens_hsa047212.74667602
3Pentose and glucuronate interconversions_Homo sapiens_hsa000402.62459296
4Linoleic acid metabolism_Homo sapiens_hsa005912.40391908
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.40165045
6RNA degradation_Homo sapiens_hsa030182.33332464
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.32663931
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.20681247
9Nitrogen metabolism_Homo sapiens_hsa009102.17644453
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15442124
11GABAergic synapse_Homo sapiens_hsa047272.13259086
12Protein export_Homo sapiens_hsa030602.11374404
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04791754
14Amphetamine addiction_Homo sapiens_hsa050312.04552270
15Glutamatergic synapse_Homo sapiens_hsa047241.99883803
16Ribosome_Homo sapiens_hsa030101.98689656
17Circadian entrainment_Homo sapiens_hsa047131.97580308
18Ether lipid metabolism_Homo sapiens_hsa005651.93990746
19Long-term potentiation_Homo sapiens_hsa047201.93452584
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.90206813
21Olfactory transduction_Homo sapiens_hsa047401.90204250
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.85815531
23Homologous recombination_Homo sapiens_hsa034401.81743902
24Morphine addiction_Homo sapiens_hsa050321.80862539
25Sulfur relay system_Homo sapiens_hsa041221.80185417
26Arginine biosynthesis_Homo sapiens_hsa002201.77384553
27Dopaminergic synapse_Homo sapiens_hsa047281.77350307
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.77252160
29Taste transduction_Homo sapiens_hsa047421.65256767
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61820599
31Collecting duct acid secretion_Homo sapiens_hsa049661.61719653
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.60995686
33Butanoate metabolism_Homo sapiens_hsa006501.59649209
34Selenocompound metabolism_Homo sapiens_hsa004501.58107677
35Salivary secretion_Homo sapiens_hsa049701.54645422
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.46492809
37RNA polymerase_Homo sapiens_hsa030201.46395787
38Serotonergic synapse_Homo sapiens_hsa047261.45153791
39One carbon pool by folate_Homo sapiens_hsa006701.44966495
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43928286
41Proteasome_Homo sapiens_hsa030501.40530154
42Cocaine addiction_Homo sapiens_hsa050301.39826825
43Insulin secretion_Homo sapiens_hsa049111.38838341
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37154253
45Renin secretion_Homo sapiens_hsa049241.33480589
46Cholinergic synapse_Homo sapiens_hsa047251.31094737
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30698489
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28722034
49Arachidonic acid metabolism_Homo sapiens_hsa005901.27880831
50Long-term depression_Homo sapiens_hsa047301.25712029
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25315790
52Basal transcription factors_Homo sapiens_hsa030221.22590738
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22110743
54Aldosterone synthesis and secretion_Homo sapiens_hsa049251.19122950
55Non-homologous end-joining_Homo sapiens_hsa034501.18282333
56Calcium signaling pathway_Homo sapiens_hsa040201.17825564
57Mismatch repair_Homo sapiens_hsa034301.16607399
58Vitamin digestion and absorption_Homo sapiens_hsa049771.15500930
59Oxidative phosphorylation_Homo sapiens_hsa001901.14908757
60Bile secretion_Homo sapiens_hsa049761.14565593
61Gastric acid secretion_Homo sapiens_hsa049711.13430869
62Complement and coagulation cascades_Homo sapiens_hsa046101.11785154
63mRNA surveillance pathway_Homo sapiens_hsa030151.11537391
64Starch and sucrose metabolism_Homo sapiens_hsa005001.10930870
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06986250
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.06522012
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04679475
68Oxytocin signaling pathway_Homo sapiens_hsa049211.03329387
69Pyruvate metabolism_Homo sapiens_hsa006201.01351713
70Axon guidance_Homo sapiens_hsa043600.97409463
71Fanconi anemia pathway_Homo sapiens_hsa034600.95725593
72Tryptophan metabolism_Homo sapiens_hsa003800.95653272
73Alzheimers disease_Homo sapiens_hsa050100.95207210
74RNA transport_Homo sapiens_hsa030130.94910132
75Cell cycle_Homo sapiens_hsa041100.94355968
76Fatty acid elongation_Homo sapiens_hsa000620.91655046
77Gap junction_Homo sapiens_hsa045400.90750134
78GnRH signaling pathway_Homo sapiens_hsa049120.89748509
79Steroid biosynthesis_Homo sapiens_hsa001000.88644040
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87150755
81Propanoate metabolism_Homo sapiens_hsa006400.86322051
82Phenylalanine metabolism_Homo sapiens_hsa003600.85859723
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85334730
84Tyrosine metabolism_Homo sapiens_hsa003500.85200336
85Vibrio cholerae infection_Homo sapiens_hsa051100.84317115
86Fatty acid metabolism_Homo sapiens_hsa012120.83671902
87Parkinsons disease_Homo sapiens_hsa050120.83285284
88Cardiac muscle contraction_Homo sapiens_hsa042600.82801570
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81266059
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81028931
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78948576
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78039187
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76131926
94cAMP signaling pathway_Homo sapiens_hsa040240.75136975
95Peroxisome_Homo sapiens_hsa041460.74324665
96Phototransduction_Homo sapiens_hsa047440.73768331
97Fatty acid degradation_Homo sapiens_hsa000710.73204257
98Basal cell carcinoma_Homo sapiens_hsa052170.72967440
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.69887500
100Regulation of autophagy_Homo sapiens_hsa041400.69501781
101Oocyte meiosis_Homo sapiens_hsa041140.66972216
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66877732
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65901227
104ErbB signaling pathway_Homo sapiens_hsa040120.65754438
105PPAR signaling pathway_Homo sapiens_hsa033200.64628942
106Melanogenesis_Homo sapiens_hsa049160.64294698
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.62842820
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62238727
109Prion diseases_Homo sapiens_hsa050200.62035382
110Histidine metabolism_Homo sapiens_hsa003400.61820094
111Glucagon signaling pathway_Homo sapiens_hsa049220.61537571
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59989717
113* Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59773549
114Purine metabolism_Homo sapiens_hsa002300.59735344
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59171444
116TGF-beta signaling pathway_Homo sapiens_hsa043500.58636118
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.57966589
118Sulfur metabolism_Homo sapiens_hsa009200.57517330
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57008886
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53201977
121Arginine and proline metabolism_Homo sapiens_hsa003300.53051603
122Estrogen signaling pathway_Homo sapiens_hsa049150.52865053
123Glioma_Homo sapiens_hsa052140.51654004
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51528751
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51100202
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50799848
127Fat digestion and absorption_Homo sapiens_hsa049750.50622910
128* Metabolic pathways_Homo sapiens_hsa011000.49427331
129Dorso-ventral axis formation_Homo sapiens_hsa043200.49416407
130Type II diabetes mellitus_Homo sapiens_hsa049300.49155384
131Caffeine metabolism_Homo sapiens_hsa002320.48131693
132Chemical carcinogenesis_Homo sapiens_hsa052040.46015471
133Pyrimidine metabolism_Homo sapiens_hsa002400.45786664
134DNA replication_Homo sapiens_hsa030300.45108068
135Thyroid hormone synthesis_Homo sapiens_hsa049180.44862900
136Fatty acid biosynthesis_Homo sapiens_hsa000610.43865675
137Cysteine and methionine metabolism_Homo sapiens_hsa002700.41608752
138Retinol metabolism_Homo sapiens_hsa008300.39719059
139Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37752863
140Huntingtons disease_Homo sapiens_hsa050160.37312635
141p53 signaling pathway_Homo sapiens_hsa041150.37290899
142beta-Alanine metabolism_Homo sapiens_hsa004100.36457300
143Wnt signaling pathway_Homo sapiens_hsa043100.35369296
144Pancreatic secretion_Homo sapiens_hsa049720.32951395
145Ovarian steroidogenesis_Homo sapiens_hsa049130.31605750
146Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31507504
147African trypanosomiasis_Homo sapiens_hsa051430.30847668
148Hedgehog signaling pathway_Homo sapiens_hsa043400.29550130
149Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29354890
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.27489447
151Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26415901

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