B3GALNT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the glycosyltransferase 31 family. The encoded protein synthesizes GalNAc:beta-1,3GlcNAc, a novel carbohydrate structure, on N- and O-glycans. Alternatively spliced transcript variants that encode different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1IMP metabolic process (GO:0046040)4.96488933
2DNA unwinding involved in DNA replication (GO:0006268)4.90891463
3IMP biosynthetic process (GO:0006188)4.90106637
4ribosomal small subunit assembly (GO:0000028)4.86657071
5folic acid-containing compound biosynthetic process (GO:0009396)4.75869287
6DNA replication initiation (GO:0006270)4.37789090
7viral transcription (GO:0019083)4.04414837
8DNA strand elongation involved in DNA replication (GO:0006271)3.98408930
9translational termination (GO:0006415)3.98168587
10DNA strand elongation (GO:0022616)3.82338675
11regulation of translational fidelity (GO:0006450)3.74365973
12translational elongation (GO:0006414)3.73640693
13nucleobase biosynthetic process (GO:0046112)3.69252863
14regulation of centriole replication (GO:0046599)3.67154802
15regulation of hippo signaling (GO:0035330)3.55597100
16telomere maintenance via semi-conservative replication (GO:0032201)3.52336164
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.52261679
18regulation of centrosome cycle (GO:0046605)3.45903296
19protein localization to kinetochore (GO:0034501)3.42326297
20DNA topological change (GO:0006265)3.40145472
21protein targeting to ER (GO:0045047)3.39344243
22meiotic chromosome segregation (GO:0045132)3.38222652
23cotranslational protein targeting to membrane (GO:0006613)3.37008088
24regulation of centrosome duplication (GO:0010824)3.35980641
25valine metabolic process (GO:0006573)3.35058210
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.33612310
27replication fork processing (GO:0031297)3.31892938
28lysine catabolic process (GO:0006554)3.31491838
29lysine metabolic process (GO:0006553)3.31491838
30translational initiation (GO:0006413)3.27416638
31establishment of protein localization to endoplasmic reticulum (GO:0072599)3.26897682
32one-carbon metabolic process (GO:0006730)3.25617121
33purine nucleobase biosynthetic process (GO:0009113)3.25431219
34mitotic sister chromatid cohesion (GO:0007064)3.24639281
35protein localization to endoplasmic reticulum (GO:0070972)3.23462406
36kynurenine metabolic process (GO:0070189)3.21139207
37mitotic nuclear envelope disassembly (GO:0007077)3.20082018
38nuclear pore complex assembly (GO:0051292)3.18793899
39folic acid metabolic process (GO:0046655)3.16811862
40RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.16406065
41nuclear pore organization (GO:0006999)3.16229249
42protein K6-linked ubiquitination (GO:0085020)3.12532414
43pteridine-containing compound biosynthetic process (GO:0042559)3.11053358
44DNA replication checkpoint (GO:0000076)3.10373515
45tetrahydrofolate metabolic process (GO:0046653)3.09750710
46protein localization to chromosome, centromeric region (GO:0071459)3.06580634
47behavioral response to nicotine (GO:0035095)3.05913420
48somatic diversification of immune receptors via somatic mutation (GO:0002566)3.01139075
49somatic hypermutation of immunoglobulin genes (GO:0016446)3.01139075
50telomere maintenance via recombination (GO:0000722)3.00960305
51DNA deamination (GO:0045006)3.00551241
52purine nucleotide salvage (GO:0032261)3.00210291
53interkinetic nuclear migration (GO:0022027)3.00156840
54membrane disassembly (GO:0030397)2.98881633
55nuclear envelope disassembly (GO:0051081)2.98881633
56viral life cycle (GO:0019058)2.98702294
57maturation of SSU-rRNA (GO:0030490)2.96680194
58mitotic chromosome condensation (GO:0007076)2.94005257
59snRNA transcription (GO:0009301)2.93433642
60cellular protein complex disassembly (GO:0043624)2.93104237
61formation of translation preinitiation complex (GO:0001731)2.93048094
62mitotic recombination (GO:0006312)2.90244070
63piRNA metabolic process (GO:0034587)2.89233785
64rRNA catabolic process (GO:0016075)2.88436996
65maturation of 5.8S rRNA (GO:0000460)2.88293714
66DNA duplex unwinding (GO:0032508)2.86813232
67histone-serine phosphorylation (GO:0035404)2.86290045
68double-strand break repair via homologous recombination (GO:0000724)2.86267010
69recombinational repair (GO:0000725)2.84012699
70telomere maintenance via telomere lengthening (GO:0010833)2.83754695
71negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.83239542
72DNA geometric change (GO:0032392)2.82519059
73centriole replication (GO:0007099)2.81469718
74cysteine metabolic process (GO:0006534)2.81408527
75negative regulation of RNA splicing (GO:0033119)2.79149153
76protein K11-linked deubiquitination (GO:0035871)2.79010314
77gene silencing by RNA (GO:0031047)2.78709340
78glycine metabolic process (GO:0006544)2.78004840
79mitochondrial DNA replication (GO:0006264)2.77216821
80regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.76526155
81ribosomal large subunit biogenesis (GO:0042273)2.75676639
82reciprocal meiotic recombination (GO:0007131)2.74652995
83reciprocal DNA recombination (GO:0035825)2.74652995
84pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.72924975
85tryptophan catabolic process (GO:0006569)2.71688407
86indole-containing compound catabolic process (GO:0042436)2.71688407
87indolalkylamine catabolic process (GO:0046218)2.71688407
88purine-containing compound salvage (GO:0043101)2.70981324
89chromatin remodeling at centromere (GO:0031055)2.70887560
90CENP-A containing nucleosome assembly (GO:0034080)2.70538477
91microtubule anchoring (GO:0034453)2.70399181
92DNA replication-dependent nucleosome assembly (GO:0006335)2.69350426
93DNA replication-dependent nucleosome organization (GO:0034723)2.69350426
94DNA replication-independent nucleosome organization (GO:0034724)2.68009113
95DNA replication-independent nucleosome assembly (GO:0006336)2.68009113
96nuclear-transcribed mRNA catabolic process (GO:0000956)2.67542535
97protein complex disassembly (GO:0043241)2.66865560
98negative regulation of histone methylation (GO:0031061)2.66186795
99DNA double-strand break processing (GO:0000729)2.63410469
100mitochondrial DNA metabolic process (GO:0032042)2.62341820
101AMP metabolic process (GO:0046033)2.61873746
102pseudouridine synthesis (GO:0001522)2.61837136
103regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.61592912
104oxaloacetate metabolic process (GO:0006107)2.60990669
105mRNA catabolic process (GO:0006402)2.58699529
106ribosome biogenesis (GO:0042254)2.58247362
107RNA catabolic process (GO:0006401)2.57913959
108replicative senescence (GO:0090399)2.57428547
109Golgi transport vesicle coating (GO:0048200)2.57390402
110COPI coating of Golgi vesicle (GO:0048205)2.57390402
111ribonucleoprotein complex biogenesis (GO:0022613)2.55882191
112positive regulation of mitotic sister chromatid separation (GO:1901970)2.55317255
113positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.55317255
114positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.55317255
115cellular hyperosmotic response (GO:0071474)2.55110964
116ethanol oxidation (GO:0006069)2.54981646
117maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.54258849
118ncRNA catabolic process (GO:0034661)2.54004261
119pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.53896553
120ribosomal small subunit biogenesis (GO:0042274)2.53213188
121regulation of nuclear cell cycle DNA replication (GO:0033262)2.52687527
122nucleotide-excision repair, DNA gap filling (GO:0006297)2.52118165
123macromolecular complex disassembly (GO:0032984)2.51942114
124regulation of spindle organization (GO:0090224)2.51646600
125DNA-dependent DNA replication (GO:0006261)2.50510228
126chromatin assembly or disassembly (GO:0006333)2.50147434
127folic acid-containing compound metabolic process (GO:0006760)2.49818404
128regulation of DNA endoreduplication (GO:0032875)2.48288886
129metaphase plate congression (GO:0051310)2.48060528
130negative regulation of DNA-dependent DNA replication (GO:2000104)2.47939426
131detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.47912268
132sister chromatid segregation (GO:0000819)2.47815917
133negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.47287722
134mitotic metaphase plate congression (GO:0007080)2.46926987
135protein autoprocessing (GO:0016540)2.46443635
136negative regulation of cytosolic calcium ion concentration (GO:0051481)2.45174090
137serine family amino acid biosynthetic process (GO:0009070)2.45161326
138kinetochore organization (GO:0051383)2.44607602
139DNA conformation change (GO:0071103)2.44176653
140regulation of glucokinase activity (GO:0033131)2.44002048
141regulation of hexokinase activity (GO:1903299)2.44002048
142monoubiquitinated protein deubiquitination (GO:0035520)2.43975814
143centrosome organization (GO:0051297)2.43896104
1443-UTR-mediated mRNA stabilization (GO:0070935)2.43638180
145heme biosynthetic process (GO:0006783)2.42954569
146mitochondrial RNA metabolic process (GO:0000959)2.42128794
147aspartate family amino acid catabolic process (GO:0009068)2.40657078
148pore complex assembly (GO:0046931)2.39934248
149positive regulation of histone H3-K4 methylation (GO:0051571)2.39476757
150regulation of histone H3-K9 methylation (GO:0051570)2.39428078
151synapsis (GO:0007129)2.39317662
152amino acid activation (GO:0043038)2.39032868
153tRNA aminoacylation (GO:0043039)2.39032868
154purine nucleobase metabolic process (GO:0006144)2.38778649
155response to pheromone (GO:0019236)2.38283202
156resolution of meiotic recombination intermediates (GO:0000712)2.36353087
157tryptophan metabolic process (GO:0006568)2.34689511
158mitotic sister chromatid segregation (GO:0000070)2.34364530
159microtubule organizing center organization (GO:0031023)2.34337400
160negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.34175029
161negative regulation of translation, ncRNA-mediated (GO:0040033)2.34175029
162regulation of translation, ncRNA-mediated (GO:0045974)2.34175029
163ubiquinone biosynthetic process (GO:0006744)2.33940843
164DNA methylation involved in gamete generation (GO:0043046)2.33732602
165indolalkylamine metabolic process (GO:0006586)2.30620369
166notochord development (GO:0030903)2.29257115
167spindle checkpoint (GO:0031577)2.28859627
168UDP-N-acetylglucosamine metabolic process (GO:0006047)2.28267769
169ubiquinone metabolic process (GO:0006743)2.28122718
170peptidyl-histidine modification (GO:0018202)2.26960158
171nucleotide transmembrane transport (GO:1901679)2.26648059
172translesion synthesis (GO:0019985)2.26216067
173somatic diversification of immunoglobulins (GO:0016445)2.25061613
174regulation of acrosome reaction (GO:0060046)2.24063859
175regulation of gene silencing by RNA (GO:0060966)2.23509259
176regulation of posttranscriptional gene silencing (GO:0060147)2.23509259
177regulation of gene silencing by miRNA (GO:0060964)2.23509259
178dorsal/ventral axis specification (GO:0009950)2.22910411
179nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.22490091
180behavioral response to ethanol (GO:0048149)2.21871870
181kinetochore assembly (GO:0051382)2.21175894
182protein import into peroxisome matrix (GO:0016558)2.20491595
183histone H3-K9 methylation (GO:0051567)2.19739180
184exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.19395553
185muscle filament sliding (GO:0030049)2.18421435

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.18298957
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.97550554
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.84549916
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.42636835
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.24241751
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.09642776
7ZNF274_21170338_ChIP-Seq_K562_Hela2.91961255
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60539769
9VDR_22108803_ChIP-Seq_LS180_Human2.57857322
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.57044484
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.52524843
12MYC_22102868_ChIP-Seq_BL_Human2.37420286
13* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.34518771
14FUS_26573619_Chip-Seq_HEK293_Human2.34123373
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.33352056
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.30743189
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.28894081
18AR_21909140_ChIP-Seq_LNCAP_Human2.28674227
19IGF1R_20145208_ChIP-Seq_DFB_Human2.25052641
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.23959971
21EWS_26573619_Chip-Seq_HEK293_Human2.22220430
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.20521210
23GATA1_22025678_ChIP-Seq_K562_Human2.16013309
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15567885
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.06521768
26GBX2_23144817_ChIP-Seq_PC3_Human2.05854032
27* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03120645
28TAF15_26573619_Chip-Seq_HEK293_Human2.02196427
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94304876
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.93959355
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.93229695
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89301942
33XRN2_22483619_ChIP-Seq_HELA_Human1.86099310
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84368230
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82859281
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.81963813
37CIITA_25753668_ChIP-Seq_RAJI_Human1.81476599
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81002191
39* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.79091455
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.78996813
41* ETS1_20019798_ChIP-Seq_JURKAT_Human1.78750225
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.78678379
43* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76180747
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.76104868
45KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73511007
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72728718
47ER_23166858_ChIP-Seq_MCF-7_Human1.69684071
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68645636
49FOXP3_21729870_ChIP-Seq_TREG_Human1.66680997
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.66303615
51P300_19829295_ChIP-Seq_ESCs_Human1.64421812
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.63833527
53VDR_23849224_ChIP-Seq_CD4+_Human1.62270167
54STAT3_23295773_ChIP-Seq_U87_Human1.61854774
55IRF1_19129219_ChIP-ChIP_H3396_Human1.60913389
56DCP1A_22483619_ChIP-Seq_HELA_Human1.60236991
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57415018
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55494860
59* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54498134
60SCL_19346495_ChIP-Seq_HPC-7_Human1.54422135
61HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.54157278
62PPARA_22158963_ChIP-Seq_LIVER_Mouse1.53548556
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53160579
64GABP_19822575_ChIP-Seq_HepG2_Human1.53090597
65TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.51412849
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50842767
67RXR_22158963_ChIP-Seq_LIVER_Mouse1.50730134
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50588689
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.50363264
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48689983
71CBP_20019798_ChIP-Seq_JUKART_Human1.48689983
72* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48157691
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.47162384
74* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46438773
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45669155
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45392249
77MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.44289492
78VDR_21846776_ChIP-Seq_THP-1_Human1.42100196
79KDM5A_27292631_Chip-Seq_BREAST_Human1.41833619
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41098805
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40959656
82MYC_18940864_ChIP-ChIP_HL60_Human1.40879948
83SMAD4_21799915_ChIP-Seq_A2780_Human1.40229800
84TCF4_23295773_ChIP-Seq_U87_Human1.39887339
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.39346007
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38655659
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37302842
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37153980
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37050019
90SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36924112
91ELK1_19687146_ChIP-ChIP_HELA_Human1.35230764
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33908717
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32159176
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30325358
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.29908975
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29886668
97TTF2_22483619_ChIP-Seq_HELA_Human1.29658050
98FOXM1_26456572_ChIP-Seq_MCF-7_Human1.28466542
99TP63_19390658_ChIP-ChIP_HaCaT_Human1.27924939
100EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27798153
101FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27701960
102TP53_16413492_ChIP-PET_HCT116_Human1.27614030
103* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27568146
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27547690
105MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27545597
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26747767
107SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25680379
108PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25359567
109CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24587379
110PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24574110
111TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23594499
112HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20636218
113NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18968598
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18110368
115SRF_21415370_ChIP-Seq_HL-1_Mouse1.17683393
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17392831
117YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15358650
118NFE2_27457419_Chip-Seq_LIVER_Mouse1.14875200
119AR_25329375_ChIP-Seq_VCAP_Human1.14740854
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14714864
121* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13753996
122MYB_21317192_ChIP-Seq_ERMYB_Mouse1.13438655
123ZNF263_19887448_ChIP-Seq_K562_Human1.13387281
124BCAT_22108803_ChIP-Seq_LS180_Human1.12693788
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12440674
126* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11880577
127CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10839874
128KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10163999
129NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.09522284
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09500036
131PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08610474
132RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08000443
133SMAD3_21741376_ChIP-Seq_EPCs_Human1.07974100
134GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06745895
135GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06173351
136AR_21572438_ChIP-Seq_LNCaP_Human1.06042524
137* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04746873
138* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04637027
139MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04560304
140TP53_22573176_ChIP-Seq_HFKS_Human1.04499306
141OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03954345
142ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03809694
143TCF4_22108803_ChIP-Seq_LS180_Human1.03544536
144* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03434252
145CDX2_22108803_ChIP-Seq_LS180_Human1.03031500
146POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02925365
147TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02925365
148SOX2_19829295_ChIP-Seq_ESCs_Human1.02289340
149NANOG_19829295_ChIP-Seq_ESCs_Human1.02289340
150MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02245154
151TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01802208
152NANOG_18555785_Chip-Seq_ESCs_Mouse1.01681674
153* TCF7_22412390_ChIP-Seq_EML_Mouse1.01340868
154CRX_20693478_ChIP-Seq_RETINA_Mouse1.00815781
155TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00727805
156* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00480459
157TFEB_21752829_ChIP-Seq_HELA_Human1.00240510
158RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00156305
159SOX9_26525672_Chip-Seq_HEART_Mouse0.99424399
160MAF_26560356_Chip-Seq_TH1_Human0.99390931
161NOTCH1_21737748_ChIP-Seq_TLL_Human0.99047075
162TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98983262
163ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98940899
164* FLI1_21867929_ChIP-Seq_TH2_Mouse0.98634211
165* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98629530
166* NFYB_21822215_ChIP-Seq_K562_Human0.98560550
167E2F1_18555785_Chip-Seq_ESCs_Mouse0.98352124
168CLOCK_20551151_ChIP-Seq_293T_Human0.97486620
169POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97046785
170DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95902656
171* CHD1_26751641_Chip-Seq_LNCaP_Human0.95534346
172HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94294861
173RUNX2_22187159_ChIP-Seq_PCA_Human0.94044808
174NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93395670
175SMAD4_21741376_ChIP-Seq_EPCs_Human0.93130131
176CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92661191
177PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92088043
178SPI1_23547873_ChIP-Seq_NB4_Human0.91882428

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.01769210
2MP0006054_spinal_hemorrhage2.77491175
3MP0003693_abnormal_embryo_hatching2.76451701
4MP0003806_abnormal_nucleotide_metabolis2.73556396
5MP0002396_abnormal_hematopoietic_system2.67249280
6MP0003656_abnormal_erythrocyte_physiolo2.53323609
7MP0004957_abnormal_blastocyst_morpholog2.51595903
8MP0010094_abnormal_chromosome_stability2.48199465
9MP0003950_abnormal_plasma_membrane2.43128152
10MP0003718_maternal_effect2.43020328
11MP0003111_abnormal_nucleus_morphology2.27924681
12MP0005365_abnormal_bile_salt2.23807674
13MP0008877_abnormal_DNA_methylation2.16270348
14MP0005360_urolithiasis2.11434636
15MP0003077_abnormal_cell_cycle2.03497383
16MP0005085_abnormal_gallbladder_physiolo2.01793495
17MP0000569_abnormal_digit_pigmentation2.00156622
18MP0003705_abnormal_hypodermis_morpholog1.97906849
19MP0004147_increased_porphyrin_level1.94328576
20MP0005083_abnormal_biliary_tract1.94210274
21MP0003937_abnormal_limbs/digits/tail_de1.90148665
22MP0002234_abnormal_pharynx_morphology1.88205217
23MP0008007_abnormal_cellular_replicative1.86349364
24MP0005397_hematopoietic_system_phenotyp1.85779183
25MP0001545_abnormal_hematopoietic_system1.85779183
26MP0000749_muscle_degeneration1.85342456
27MP0004808_abnormal_hematopoietic_stem1.84635584
28MP0010352_gastrointestinal_tract_polyps1.81244300
29MP0000427_abnormal_hair_cycle1.79709054
30MP0002837_dystrophic_cardiac_calcinosis1.74261494
31MP0000383_abnormal_hair_follicle1.72838783
32MP0003123_paternal_imprinting1.72517040
33MP0006292_abnormal_olfactory_placode1.70141145
34MP0008057_abnormal_DNA_replication1.68309296
35MP0003646_muscle_fatigue1.67544515
36MP0004145_abnormal_muscle_electrophysio1.62544562
37MP0002269_muscular_atrophy1.62082368
38MP0002938_white_spotting1.61783618
39MP0008058_abnormal_DNA_repair1.55417406
40MP0000490_abnormal_crypts_of1.50886268
41MP0003252_abnormal_bile_duct1.50543287
42MP0003136_yellow_coat_color1.48729948
43MP0004233_abnormal_muscle_weight1.46671806
44MP0006072_abnormal_retinal_apoptosis1.45682101
45MP0001730_embryonic_growth_arrest1.40572824
46MP0010678_abnormal_skin_adnexa1.39304979
47MP0003890_abnormal_embryonic-extraembry1.38344734
48MP0006036_abnormal_mitochondrial_physio1.37914232
49MP0001666_abnormal_nutrient_absorption1.34135078
50MP0005551_abnormal_eye_electrophysiolog1.33374493
51MP0005220_abnormal_exocrine_pancreas1.32067091
52MP0000751_myopathy1.32018053
53MP0000647_abnormal_sebaceous_gland1.31001186
54MP0003941_abnormal_skin_development1.28383028
55MP0000747_muscle_weakness1.27570058
56MP0002166_altered_tumor_susceptibility1.27312710
57MP0001293_anophthalmia1.23891929
58MP0005187_abnormal_penis_morphology1.23141307
59MP0001661_extended_life_span1.20766083
60MP0005253_abnormal_eye_physiology1.20366018
61MP0005395_other_phenotype1.15984447
62MP0002160_abnormal_reproductive_system1.15886512
63MP0003567_abnormal_fetal_cardiomyocyte1.15399016
64MP0000350_abnormal_cell_proliferation1.15144586
65MP0002876_abnormal_thyroid_physiology1.14862144
66MP0000733_abnormal_muscle_development1.12697152
67MP0002019_abnormal_tumor_incidence1.11913202
68MP0000631_abnormal_neuroendocrine_gland1.10327557
69MP0002106_abnormal_muscle_physiology1.10060917
70MP0003755_abnormal_palate_morphology1.09922219
71MP0000750_abnormal_muscle_regeneration1.09257276
72MP0002233_abnormal_nose_morphology1.07655087
73MP0002080_prenatal_lethality1.06442158
74MP0006035_abnormal_mitochondrial_morpho1.06438660
75MP0001697_abnormal_embryo_size1.06129714
76MP0002086_abnormal_extraembryonic_tissu1.06116969
77MP0001929_abnormal_gametogenesis1.05971030
78MP0005319_abnormal_enzyme/_coenzyme1.04771461
79MP0000566_synostosis1.04646187
80MP0003786_premature_aging1.04624761
81MP0010030_abnormal_orbit_morphology1.04315351
82MP0000759_abnormal_skeletal_muscle1.02197018
83MP0000609_abnormal_liver_physiology1.02067171
84MP0005620_abnormal_muscle_contractility1.01090830
85MP0003195_calcinosis1.00784020
86MP0004087_abnormal_muscle_fiber1.00626616
87MP0000598_abnormal_liver_morphology1.00553912
88MP0004197_abnormal_fetal_growth/weight/1.00503414
89MP0008789_abnormal_olfactory_epithelium1.00269433
90MP0003943_abnormal_hepatobiliary_system0.99148993
91MP0002138_abnormal_hepatobiliary_system0.98466070
92MP0004043_abnormal_pH_regulation0.98141225
93MP0000372_irregular_coat_pigmentation0.97889528
94MP0002210_abnormal_sex_determination0.97569272
95MP0008932_abnormal_embryonic_tissue0.96927741
96MP0003763_abnormal_thymus_physiology0.96709162
97MP0008775_abnormal_heart_ventricle0.96196356
98MP0010329_abnormal_lipoprotein_level0.96158902
99MP0002102_abnormal_ear_morphology0.94882662
100MP0004130_abnormal_muscle_cell0.94023439
101MP0008875_abnormal_xenobiotic_pharmacok0.93503638
102MP0004134_abnormal_chest_morphology0.93222272
103MP0003566_abnormal_cell_adhesion0.92272582
104MP0002697_abnormal_eye_size0.92165225
105MP0003221_abnormal_cardiomyocyte_apopto0.91632230
106MP0002398_abnormal_bone_marrow0.91361516
107MP0010234_abnormal_vibrissa_follicle0.91316766
108MP0000465_gastrointestinal_hemorrhage0.90575660
109MP0000013_abnormal_adipose_tissue0.90360317
110MP0000689_abnormal_spleen_morphology0.90207654
111MP0000762_abnormal_tongue_morphology0.90016445
112MP0005380_embryogenesis_phenotype0.89282305
113MP0001672_abnormal_embryogenesis/_devel0.89282305
114MP0003984_embryonic_growth_retardation0.89202347
115MP0004036_abnormal_muscle_relaxation0.88417956
116MP0003868_abnormal_feces_composition0.88015262
117MP0002088_abnormal_embryonic_growth/wei0.87912882
118MP0001873_stomach_inflammation0.87456229
119MP0003300_gastrointestinal_ulcer0.87274427
120MP0005391_vision/eye_phenotype0.86809667
121MP0002722_abnormal_immune_system0.86705580
122MP0003186_abnormal_redox_activity0.86352022
123MP0000579_abnormal_nail_morphology0.86271700
124MP0010307_abnormal_tumor_latency0.86017526
125MP0000358_abnormal_cell_content/0.85949619
126MP0002009_preneoplasia0.85780723
127MP0004215_abnormal_myocardial_fiber0.84810908
128MP0005389_reproductive_system_phenotype0.84400467
129MP0005266_abnormal_metabolism0.84112853
130MP0004133_heterotaxia0.84062408
131MP0003698_abnormal_male_reproductive0.83709370
132MP0004264_abnormal_extraembryonic_tissu0.83414516
133MP0000428_abnormal_craniofacial_morphol0.83201256
134MP0010368_abnormal_lymphatic_system0.82608001
135MP0000653_abnormal_sex_gland0.81851897
136MP0000049_abnormal_middle_ear0.81725962
137MP0002084_abnormal_developmental_patter0.80915640
138MP0002108_abnormal_muscle_morphology0.80630518
139MP0001299_abnormal_eye_distance/0.80562506
140MP0005023_abnormal_wound_healing0.80353325
141MP0002638_abnormal_pupillary_reflex0.79999339
142MP0002095_abnormal_skin_pigmentation0.79762592
143MP0001286_abnormal_eye_development0.79638688
144MP0000703_abnormal_thymus_morphology0.79634454
145MP0005369_muscle_phenotype0.79110150
146MP0000313_abnormal_cell_death0.78974153
147MP0009672_abnormal_birth_weight0.77496000
148MP0001853_heart_inflammation0.77091103
149MP0002006_tumorigenesis0.76960832
150MP0009250_abnormal_appendicular_skeleto0.75804779
151MP0010630_abnormal_cardiac_muscle0.75719590
152MP0002085_abnormal_embryonic_tissue0.75651577
153MP0000685_abnormal_immune_system0.75243497
154MP0005171_absent_coat_pigmentation0.74854662
155MP0001145_abnormal_male_reproductive0.74546881
156MP0000538_abnormal_urinary_bladder0.73313523
157MP0009697_abnormal_copulation0.73137607
158MP0002111_abnormal_tail_morphology0.72944307
159MP0003119_abnormal_digestive_system0.71841281
160MP0005330_cardiomyopathy0.71608108
161MP0005464_abnormal_platelet_physiology0.70640663
162MP0005076_abnormal_cell_differentiation0.70580205
163MP0003191_abnormal_cellular_cholesterol0.70332285
164MP0001915_intracranial_hemorrhage0.70296429
165MP0004084_abnormal_cardiac_muscle0.70240276

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)4.12126310
2Abnormality of cells of the erythroid lineage (HP:0012130)4.06601572
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.76821155
4Muscle fiber inclusion bodies (HP:0100299)3.75765749
5Abnormality of the heme biosynthetic pathway (HP:0010472)3.69402249
6Ulnar deviation of the wrist (HP:0003049)3.65912654
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.62158562
8Chromsome breakage (HP:0040012)3.60550232
9Exercise-induced muscle cramps (HP:0003710)3.59306262
10Exercise-induced myalgia (HP:0003738)3.42939899
11Rhabdomyolysis (HP:0003201)3.38901808
12Myoglobinuria (HP:0002913)3.32119832
13Calcaneovalgus deformity (HP:0001848)3.24331584
14Nemaline bodies (HP:0003798)3.19251765
15Pancreatic cysts (HP:0001737)3.14263295
16Aplasia/Hypoplasia of the uvula (HP:0010293)3.13172739
17Distal arthrogryposis (HP:0005684)3.11108554
18Birth length less than 3rd percentile (HP:0003561)3.01918802
19Thrombocytosis (HP:0001894)2.96711877
20Type 1 muscle fiber predominance (HP:0003803)2.96282280
21Deformed tarsal bones (HP:0008119)2.96183099
22Pancreatic fibrosis (HP:0100732)2.90249556
23Reticulocytopenia (HP:0001896)2.84860644
24Abnormality of midbrain morphology (HP:0002418)2.84225234
25Molar tooth sign on MRI (HP:0002419)2.84225234
26Abnormality of the calcaneus (HP:0008364)2.82030922
27Abnormality of the renal cortex (HP:0011035)2.79920284
28Poikilocytosis (HP:0004447)2.78358781
29Abnormality of the ileum (HP:0001549)2.75609028
30Myopathic facies (HP:0002058)2.70753183
31Duplicated collecting system (HP:0000081)2.69619678
32Abnormality of reticulocytes (HP:0004312)2.68204547
33Reticulocytosis (HP:0001923)2.58835492
34Meckel diverticulum (HP:0002245)2.58787109
35True hermaphroditism (HP:0010459)2.57877709
36Nephronophthisis (HP:0000090)2.57199742
37Oral leukoplakia (HP:0002745)2.55699361
38Increased density of long bones (HP:0006392)2.53432443
39Spastic diplegia (HP:0001264)2.53180234
40Abnormality of chromosome stability (HP:0003220)2.51475688
41Volvulus (HP:0002580)2.50122777
42Aplastic anemia (HP:0001915)2.48479534
43Malignant hyperthermia (HP:0002047)2.48379777
44Renal cortical cysts (HP:0000803)2.46164152
45Round ear (HP:0100830)2.45648688
46Ectopic kidney (HP:0000086)2.44419846
47Abnormality of the renal collecting system (HP:0004742)2.44383910
48Acanthocytosis (HP:0001927)2.43522768
49Fair hair (HP:0002286)2.41928097
50Prolonged bleeding time (HP:0003010)2.41652694
51Hyperbilirubinemia (HP:0002904)2.41486012
52Rectal prolapse (HP:0002035)2.40510999
53Progressive muscle weakness (HP:0003323)2.40487551
54Abnormality of the renal medulla (HP:0100957)2.38275187
55Tubular atrophy (HP:0000092)2.37732212
56Increased serum ferritin (HP:0003281)2.37066847
57Aplasia/Hypoplasia of the tibia (HP:0005772)2.35549780
58* Type II lissencephaly (HP:0007260)2.34200615
59Gaze-evoked nystagmus (HP:0000640)2.30300807
60Pallor (HP:0000980)2.28862784
61Increased connective tissue (HP:0009025)2.28273818
62Calf muscle hypertrophy (HP:0008981)2.28066290
63Colon cancer (HP:0003003)2.26342808
64Abnormality of iron homeostasis (HP:0011031)2.25634092
65Increased mean platelet volume (HP:0011877)2.25211301
66Intrahepatic cholestasis (HP:0001406)2.24271852
67Sloping forehead (HP:0000340)2.23870305
68Petechiae (HP:0000967)2.23328820
69Chorioretinal atrophy (HP:0000533)2.22991491
70Hypobetalipoproteinemia (HP:0003563)2.21859774
71Abnormality of the preputium (HP:0100587)2.21631339
72Abnormal platelet function (HP:0011869)2.21487345
73Impaired platelet aggregation (HP:0003540)2.21487345
74Limb-girdle muscle atrophy (HP:0003797)2.20621651
75Abnormal platelet volume (HP:0011876)2.20117693
76* Cerebellar dysplasia (HP:0007033)2.18416302
77Abnormality of DNA repair (HP:0003254)2.17570093
78Patellar aplasia (HP:0006443)2.15502390
79Abnormality of monocarboxylic acid metabolism (HP:0010996)2.13564500
80Pelvic girdle muscle weakness (HP:0003749)2.13188363
81Abnormality of the musculature of the pelvis (HP:0001469)2.12530482
82Abnormality of the hip-girdle musculature (HP:0001445)2.12530482
83Abnormal biliary tract physiology (HP:0012439)2.10673904
84Bile duct proliferation (HP:0001408)2.10673904
85Chronic hepatic failure (HP:0100626)2.10232713
86Deep venous thrombosis (HP:0002625)2.09996029
87Ependymoma (HP:0002888)2.09696963
88Abnormality of transition element cation homeostasis (HP:0011030)2.07362892
89Protrusio acetabuli (HP:0003179)2.06860224
90Selective tooth agenesis (HP:0001592)2.06579980
91Gout (HP:0001997)2.05943796
92Aplasia/Hypoplasia of the patella (HP:0006498)2.04902939
93Absent phalangeal crease (HP:0006109)2.02855868
94Macrocytic anemia (HP:0001972)2.02072120
95Clubbing of toes (HP:0100760)2.00962271
96Large for gestational age (HP:0001520)1.98248276
97Aplasia/Hypoplasia of the tongue (HP:0010295)1.98135787
98Abnormality of the carotid arteries (HP:0005344)1.96606111
99Pendular nystagmus (HP:0012043)1.96241795
100Keratoconus (HP:0000563)1.95587059
101Increased corneal curvature (HP:0100692)1.95587059
102Abnormality of the intrinsic pathway (HP:0010989)1.94731327
103Glioma (HP:0009733)1.93442495
104Epistaxis (HP:0000421)1.93304322
105Muscle stiffness (HP:0003552)1.93253758
106Basal cell carcinoma (HP:0002671)1.92722592
107Absent radius (HP:0003974)1.91372856
108Congenital stationary night blindness (HP:0007642)1.90002193
109Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.89368001
110Partial agenesis of the corpus callosum (HP:0001338)1.89231393
111Biliary tract neoplasm (HP:0100574)1.89082891
112Hyperammonemia (HP:0001987)1.88688180
113Sclerocornea (HP:0000647)1.87421200
114Myelodysplasia (HP:0002863)1.86496255
115Acute myeloid leukemia (HP:0004808)1.86411224
116Metatarsus adductus (HP:0001840)1.86155529
117Hypoplastic ischia (HP:0003175)1.85962898
118Small intestinal stenosis (HP:0012848)1.85663409
119Duodenal stenosis (HP:0100867)1.85663409
120Abnormality of alanine metabolism (HP:0010916)1.85260709
121Hyperalaninemia (HP:0003348)1.85260709
122Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85260709
123Aplasia involving forearm bones (HP:0009822)1.83723882
124Absent forearm bone (HP:0003953)1.83723882
125Attenuation of retinal blood vessels (HP:0007843)1.82596353
126Hepatocellular carcinoma (HP:0001402)1.82562360
127Polycythemia (HP:0001901)1.82508843
128Medial flaring of the eyebrow (HP:0010747)1.81653416
129Abnormality of the ischium (HP:0003174)1.80716963
130Astrocytoma (HP:0009592)1.80552559
131Abnormality of the astrocytes (HP:0100707)1.80552559
132Hyperventilation (HP:0002883)1.80377262
133Rimmed vacuoles (HP:0003805)1.79878799
134Hypoplastic labia majora (HP:0000059)1.78128373
135Radial bowing (HP:0002986)1.78056634
136Type 2 muscle fiber atrophy (HP:0003554)1.77260334
137Short tibia (HP:0005736)1.76995360
138Cholelithiasis (HP:0001081)1.76147499
139Cystic liver disease (HP:0006706)1.75793507
140Ketosis (HP:0001946)1.74804828
141Muscle fiber atrophy (HP:0100295)1.74716429
142Neoplasm of the rectum (HP:0100743)1.74665947
143Limb-girdle muscle weakness (HP:0003325)1.74136168
144Broad palm (HP:0001169)1.73717206
145Abnormality of the left ventricular outflow tract (HP:0011103)1.73115573
146Subaortic stenosis (HP:0001682)1.73115573
147Shoulder girdle muscle weakness (HP:0003547)1.73091624
148Poikiloderma (HP:0001029)1.71160357
149Abnormal finger flexion creases (HP:0006143)1.70286255
150Abnormality of the labia majora (HP:0012881)1.69529940
151Hypoglycemic coma (HP:0001325)1.69344470
152Ankle contracture (HP:0006466)1.68806065
153Abnormal biliary tract morphology (HP:0012440)1.68538779
154Short thumb (HP:0009778)1.67723517
155Back pain (HP:0003418)1.67693571
156Muscle hypertrophy of the lower extremities (HP:0008968)1.67605570
157* Abnormality of the pons (HP:0007361)1.66157635
158Abnormality of aromatic amino acid family metabolism (HP:0004338)1.65608001
159Aortic regurgitation (HP:0001659)1.65256985
160Small hand (HP:0200055)1.62410517
161Protruding tongue (HP:0010808)1.61498378
162Broad face (HP:0000283)1.61001992
163Aplasia/Hypoplasia of the sternum (HP:0006714)1.60836039
164Abnormality of the thoracic spine (HP:0100711)1.60711020
165* Dandy-Walker malformation (HP:0001305)1.60572374
166Abnormality of the nasal septum (HP:0000419)1.60520489
167Abnormality of the duodenum (HP:0002246)1.60248864
168Absent thumb (HP:0009777)1.59964499
169Broad-based gait (HP:0002136)1.59131449
170* Severe muscular hypotonia (HP:0006829)1.59076625
171Aplasia/Hypoplasia of the fibula (HP:0006492)1.59054659
172Neoplasm of the small intestine (HP:0100833)1.58839862
17311 pairs of ribs (HP:0000878)1.58246930
174IgM deficiency (HP:0002850)1.58172964
175Abnormality of pyrimidine metabolism (HP:0004353)1.58022641
176Furrowed tongue (HP:0000221)1.57734393
177Astigmatism (HP:0000483)1.57001112
178Hypoplastic iliac wings (HP:0002866)1.54932342
179Fibular hypoplasia (HP:0003038)1.54205061
180Postaxial foot polydactyly (HP:0001830)1.53447721
181Triphalangeal thumb (HP:0001199)1.52538654
182Fibular aplasia (HP:0002990)1.52184829
183Supernumerary spleens (HP:0009799)1.50807953
184Thyroid-stimulating hormone excess (HP:0002925)1.50058798
185Anencephaly (HP:0002323)1.49104281

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.21480329
2EEF2K3.66207659
3TTN3.28358808
4ZAK3.25204566
5PKN23.10014549
6MAP2K32.80692454
7BMPR1B2.78914977
8BUB12.67430676
9CDC72.52307699
10EIF2AK12.48721248
11BCKDK2.37417309
12FLT32.22460993
13NME22.20907964
14MKNK22.18644998
15SCYL22.16959452
16TRIB32.11132577
17PNCK2.09117866
18WEE12.07381048
19MAP3K102.01618224
20RPS6KB21.98471265
21ADRBK21.96191303
22PBK1.85871736
23NEK21.84984256
24ACVR1B1.76171499
25PIK3CG1.73255355
26TGFBR11.72434214
27RPS6KA41.71018703
28MAPKAPK31.69553604
29NUAK11.68692125
30CDK41.65799922
31STK38L1.62860222
32TAOK31.60667472
33TNIK1.58349950
34STK391.57583110
35EIF2AK31.56037354
36GRK11.53546081
37OBSCN1.45980377
38NEK11.45921551
39MUSK1.43862471
40PHKG21.38993521
41PHKG11.38993521
42PASK1.37190041
43WNK41.35690308
44MAP3K31.35189755
45AKT31.34591192
46CAMK1G1.34076781
47STK161.33267771
48LRRK21.32946814
49MAP4K21.31444737
50ERN11.31143543
51WNK31.31099238
52TAF11.27754731
53MAP4K11.24776610
54TTK1.24644260
55CDK121.23785324
56BRSK21.22742135
57MAPK111.21866877
58STK101.21120726
59MAP3K81.21085012
60MET1.20836291
61CDK71.20802406
62CDK61.20391596
63ATR1.20334558
64PLK31.17217127
65DYRK31.16404546
66PDK41.16135408
67PDK31.16135408
68PINK11.15813064
69SIK11.15770737
70LATS11.14765229
71MAP3K41.13642976
72AURKB1.13198203
73INSRR1.09453591
74CDK81.09151007
75MAP3K71.05470611
76PAK41.05246654
77TAOK21.01742548
78PTK60.95632670
79SRPK10.94629849
80CAMK1D0.94186738
81TGFBR20.93813275
82BTK0.93481290
83NME10.91804620
84TLK10.90953165
85TSSK60.86823469
86ERBB30.83005343
87CASK0.82993104
88MAP3K110.81251242
89ZAP700.80948733
90TRIM280.80370429
91NEK90.78584614
92PLK10.77902940
93MST1R0.75600207
94PAK20.75289255
95KIT0.74785647
96TRPM70.74550917
97CSNK1G10.72990092
98CHEK10.72923553
99CSF1R0.71616520
100MELK0.71302619
101PIM10.69975496
102CSNK1A1L0.68259677
103OXSR10.67330632
104TYK20.67142322
105CCNB10.65958950
106JAK20.64332382
107IRAK10.62295974
108STK30.62010366
109TEC0.61907363
110MTOR0.61595228
111ATM0.58714927
112KDR0.57800231
113TIE10.57211667
114CHEK20.55900767
115MST40.55784649
116CSNK1G30.54763042
117PRKCI0.54130821
118VRK10.53490935
119FGFR40.52023544
120RPS6KA50.50828543
121MAPK130.50632152
122PRKCE0.50091213
123JAK30.49401556
124CDK10.49309327
125ERBB40.48524982
126MKNK10.48151673
127EIF2AK20.46439037
128PDGFRA0.46396667
129NLK0.44714517
130MAP2K60.44694711
131MAPKAPK50.44616839
132AKT20.43985188
133BCR0.43791428
134PIM20.43278975
135BRD40.41666329
136CDK20.41299836
137ADRBK10.40348660
138STK40.39774355
139MAP3K50.39481096
140RPS6KB10.37876022
141STK240.37464084
142RAF10.37418049
143PKN10.36427222
144BRSK10.36114724
145MAP3K60.36045252
146EPHA20.35223862
147FGFR10.35054713
148CSNK2A20.34282273
149TAOK10.33786781
150PRKAA20.33470799
151PRKAA10.31844652
152DYRK1B0.31680329
153CDK190.30973407
154PLK40.30537278
155PIK3CA0.29917081

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.21511897
2One carbon pool by folate_Homo sapiens_hsa006702.80365491
3Mismatch repair_Homo sapiens_hsa034302.74002085
4Ribosome_Homo sapiens_hsa030102.70022322
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.35965952
6Selenocompound metabolism_Homo sapiens_hsa004502.27044857
7Homologous recombination_Homo sapiens_hsa034401.94612394
8Cell cycle_Homo sapiens_hsa041101.92855010
9Base excision repair_Homo sapiens_hsa034101.92131099
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90319505
11Spliceosome_Homo sapiens_hsa030401.88983394
12RNA transport_Homo sapiens_hsa030131.88121686
13Nucleotide excision repair_Homo sapiens_hsa034201.76809476
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.75526187
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.70920596
16Cysteine and methionine metabolism_Homo sapiens_hsa002701.70197555
17Pyrimidine metabolism_Homo sapiens_hsa002401.68178096
18Biosynthesis of amino acids_Homo sapiens_hsa012301.67453158
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62941758
20Sulfur relay system_Homo sapiens_hsa041221.56035645
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.52215234
22Fatty acid degradation_Homo sapiens_hsa000711.51011633
23Folate biosynthesis_Homo sapiens_hsa007901.50576085
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.48561128
25RNA degradation_Homo sapiens_hsa030181.47775165
26Propanoate metabolism_Homo sapiens_hsa006401.47219603
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.45318580
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.45115084
29Phototransduction_Homo sapiens_hsa047441.44478363
30Carbon metabolism_Homo sapiens_hsa012001.43599211
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43419232
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.41250185
33Butanoate metabolism_Homo sapiens_hsa006501.40672205
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.39692742
35Circadian rhythm_Homo sapiens_hsa047101.36889245
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34556040
37Fanconi anemia pathway_Homo sapiens_hsa034601.33149557
38p53 signaling pathway_Homo sapiens_hsa041151.30807176
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30797767
40RNA polymerase_Homo sapiens_hsa030201.29469085
41Linoleic acid metabolism_Homo sapiens_hsa005911.27485095
42Non-homologous end-joining_Homo sapiens_hsa034501.21688899
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.21141446
44Pentose phosphate pathway_Homo sapiens_hsa000301.19980794
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19403422
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18834952
47Drug metabolism - other enzymes_Homo sapiens_hsa009831.17871983
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16957608
49Pyruvate metabolism_Homo sapiens_hsa006201.15506310
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.15395681
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10849812
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05893085
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05417029
54Arginine biosynthesis_Homo sapiens_hsa002201.05213147
55Lysine degradation_Homo sapiens_hsa003101.03499410
56Systemic lupus erythematosus_Homo sapiens_hsa053221.03463206
57Caffeine metabolism_Homo sapiens_hsa002321.02313839
58TGF-beta signaling pathway_Homo sapiens_hsa043501.00753118
59Fatty acid biosynthesis_Homo sapiens_hsa000611.00273050
60Small cell lung cancer_Homo sapiens_hsa052220.98777639
61Cardiac muscle contraction_Homo sapiens_hsa042600.97524254
62Tryptophan metabolism_Homo sapiens_hsa003800.96226006
63Hippo signaling pathway_Homo sapiens_hsa043900.96187121
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90497978
65Starch and sucrose metabolism_Homo sapiens_hsa005000.89283461
66Steroid biosynthesis_Homo sapiens_hsa001000.88682513
67Purine metabolism_Homo sapiens_hsa002300.87767962
68Olfactory transduction_Homo sapiens_hsa047400.85940495
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85794852
70mRNA surveillance pathway_Homo sapiens_hsa030150.83020008
71N-Glycan biosynthesis_Homo sapiens_hsa005100.81932351
72Thyroid cancer_Homo sapiens_hsa052160.78195462
73Nitrogen metabolism_Homo sapiens_hsa009100.78036519
74Basal cell carcinoma_Homo sapiens_hsa052170.77800725
75Hedgehog signaling pathway_Homo sapiens_hsa043400.76806473
76Peroxisome_Homo sapiens_hsa041460.75383547
77Viral carcinogenesis_Homo sapiens_hsa052030.75008234
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72551214
79Herpes simplex infection_Homo sapiens_hsa051680.71529057
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70517077
81Ether lipid metabolism_Homo sapiens_hsa005650.69158293
82Complement and coagulation cascades_Homo sapiens_hsa046100.68924643
83Huntingtons disease_Homo sapiens_hsa050160.67027433
84Dilated cardiomyopathy_Homo sapiens_hsa054140.66492749
85Arginine and proline metabolism_Homo sapiens_hsa003300.65749412
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64792356
87Insulin resistance_Homo sapiens_hsa049310.64057800
88Glycerolipid metabolism_Homo sapiens_hsa005610.63871042
89Oocyte meiosis_Homo sapiens_hsa041140.63535434
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.62231188
91Chronic myeloid leukemia_Homo sapiens_hsa052200.62104077
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62000336
93Alcoholism_Homo sapiens_hsa050340.60344147
94Proteasome_Homo sapiens_hsa030500.60235923
95AMPK signaling pathway_Homo sapiens_hsa041520.59212784
96Galactose metabolism_Homo sapiens_hsa000520.58629531
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57978088
98Fatty acid metabolism_Homo sapiens_hsa012120.56194415
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55399930
100beta-Alanine metabolism_Homo sapiens_hsa004100.54792928
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53954040
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.52309461
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51935019
104HTLV-I infection_Homo sapiens_hsa051660.51476568
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50367588
106Fat digestion and absorption_Homo sapiens_hsa049750.50310457
107Antigen processing and presentation_Homo sapiens_hsa046120.50296774
108Acute myeloid leukemia_Homo sapiens_hsa052210.50106013
109Protein export_Homo sapiens_hsa030600.49444346
110Renin-angiotensin system_Homo sapiens_hsa046140.49344534
111Ovarian steroidogenesis_Homo sapiens_hsa049130.47571164
112Basal transcription factors_Homo sapiens_hsa030220.47526448
113MicroRNAs in cancer_Homo sapiens_hsa052060.47291196
114Tight junction_Homo sapiens_hsa045300.46456793
115Dorso-ventral axis formation_Homo sapiens_hsa043200.46061393
116Taste transduction_Homo sapiens_hsa047420.45694256
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.45459885
118Hematopoietic cell lineage_Homo sapiens_hsa046400.44392149
119Vitamin B6 metabolism_Homo sapiens_hsa007500.43865433
120ABC transporters_Homo sapiens_hsa020100.43349321
121Pancreatic secretion_Homo sapiens_hsa049720.43188299
122Retinol metabolism_Homo sapiens_hsa008300.42726396
123Glutathione metabolism_Homo sapiens_hsa004800.42684142
124Viral myocarditis_Homo sapiens_hsa054160.39313644
125Glucagon signaling pathway_Homo sapiens_hsa049220.39178776
126Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38917693
127Sulfur metabolism_Homo sapiens_hsa009200.37663619
128Insulin signaling pathway_Homo sapiens_hsa049100.37094473
129Epstein-Barr virus infection_Homo sapiens_hsa051690.36993580
130Bladder cancer_Homo sapiens_hsa052190.36721291
131PPAR signaling pathway_Homo sapiens_hsa033200.36542500
132Platelet activation_Homo sapiens_hsa046110.36491611
133Fructose and mannose metabolism_Homo sapiens_hsa000510.36222057
134Melanoma_Homo sapiens_hsa052180.35342444
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34690276
136Hepatitis B_Homo sapiens_hsa051610.34009395
137Chemical carcinogenesis_Homo sapiens_hsa052040.32560557
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32142839
139Oxidative phosphorylation_Homo sapiens_hsa001900.31978050
140Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31879212
141ECM-receptor interaction_Homo sapiens_hsa045120.31828321
142Metabolic pathways_Homo sapiens_hsa011000.31164876

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