B2M

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.35834158
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.35834158
3antigen processing and presentation of endogenous antigen (GO:0019883)5.79051114
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.77438077
5negative regulation of cell killing (GO:0031342)5.77438077
6ribosomal small subunit assembly (GO:0000028)5.18639394
7positive regulation of gamma-delta T cell activation (GO:0046645)4.87981224
8response to interferon-beta (GO:0035456)4.64209857
9response to interferon-alpha (GO:0035455)4.32303213
10type I interferon signaling pathway (GO:0060337)4.31696735
11cellular response to type I interferon (GO:0071357)4.31696735
12response to type I interferon (GO:0034340)4.31075024
13positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.29761655
14regulation of regulatory T cell differentiation (GO:0045589)4.20149534
15immunoglobulin mediated immune response (GO:0016064)4.19085332
16regulation of T cell tolerance induction (GO:0002664)4.10998571
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.06883930
18viral transcription (GO:0019083)4.05515739
19positive regulation of B cell differentiation (GO:0045579)3.99077451
20positive thymic T cell selection (GO:0045059)3.94594484
21cytidine metabolic process (GO:0046087)3.93002658
22cytidine catabolic process (GO:0006216)3.93002658
23cytidine deamination (GO:0009972)3.93002658
24DNA deamination (GO:0045006)3.89301755
25regulation of tolerance induction (GO:0002643)3.84307527
26translational termination (GO:0006415)3.84226179
27defense response to protozoan (GO:0042832)3.80659330
28regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.71983408
29detection of other organism (GO:0098543)3.70597722
30regulation of gamma-delta T cell differentiation (GO:0045586)3.70552311
31positive T cell selection (GO:0043368)3.66461367
32modulation by symbiont of host defense response (GO:0052031)3.64881695
33modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.64881695
34modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.64881695
35positive regulation by organism of defense response of other organism involved in symbiotic interact3.64881695
36modulation by symbiont of host immune response (GO:0052553)3.64881695
37positive regulation by symbiont of host defense response (GO:0052509)3.64881695
38B cell mediated immunity (GO:0019724)3.62170790
39regulation of B cell differentiation (GO:0045577)3.62141976
40negative regulation of interleukin-12 production (GO:0032695)3.61934407
41platelet dense granule organization (GO:0060155)3.60583479
42negative regulation of lymphocyte mediated immunity (GO:0002707)3.60420950
43detection of bacterium (GO:0016045)3.59721000
44response to protozoan (GO:0001562)3.59603098
45regulation of natural killer cell mediated immunity (GO:0002715)3.58824549
46regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.58824549
47pyrimidine ribonucleoside catabolic process (GO:0046133)3.56122359
48positive regulation of tolerance induction (GO:0002645)3.55451238
49negative regulation of T cell mediated immunity (GO:0002710)3.55115783
50neutrophil activation (GO:0042119)3.51008782
51regulation of gamma-delta T cell activation (GO:0046643)3.49571619
52definitive hemopoiesis (GO:0060216)3.46962390
53negative regulation of erythrocyte differentiation (GO:0045647)3.43828360
54cellular response to interferon-beta (GO:0035458)3.43283632
55SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.42277239
56positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.40769153
57positive regulation of alpha-beta T cell proliferation (GO:0046641)3.37081569
58regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.36773432
59regulation of B cell receptor signaling pathway (GO:0050855)3.36156240
60Arp2/3 complex-mediated actin nucleation (GO:0034314)3.34870905
61mature B cell differentiation involved in immune response (GO:0002313)3.34738390
62T cell selection (GO:0045058)3.33288722
63cotranslational protein targeting to membrane (GO:0006613)3.32525916
64protein targeting to ER (GO:0045047)3.31523080
65thymic T cell selection (GO:0045061)3.30645502
66myeloid dendritic cell activation (GO:0001773)3.29617237
67translational elongation (GO:0006414)3.27095864
68granulocyte activation (GO:0036230)3.24751152
69positive regulation of natural killer cell differentiation (GO:0032825)3.23498752
70macrophage activation involved in immune response (GO:0002281)3.23329151
71negative regulation of leukocyte mediated immunity (GO:0002704)3.23311602
72detection of external biotic stimulus (GO:0098581)3.22892694
73dendritic cell chemotaxis (GO:0002407)3.22043842
74tolerance induction (GO:0002507)3.21365702
75NIK/NF-kappaB signaling (GO:0038061)3.20859758
76mast cell activation (GO:0045576)3.19347425
77ribosomal small subunit biogenesis (GO:0042274)3.18826090
78* regulation of leukocyte mediated cytotoxicity (GO:0001910)3.18666678
79protein localization to endoplasmic reticulum (GO:0070972)3.18074336
80cellular extravasation (GO:0045123)3.17690439
81myeloid cell activation involved in immune response (GO:0002275)3.16972350
82regulation of natural killer cell differentiation (GO:0032823)3.16479918
83lymph node development (GO:0048535)3.15598971
84regulation of necroptotic process (GO:0060544)3.15356553
85leukocyte aggregation (GO:0070486)3.15008327
86microglial cell activation (GO:0001774)3.14827191
87antigen receptor-mediated signaling pathway (GO:0050851)3.14717987
88establishment of protein localization to endoplasmic reticulum (GO:0072599)3.13939381
89T cell costimulation (GO:0031295)3.13748084
90T cell receptor signaling pathway (GO:0050852)3.13446762
91* positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.12578923
92activated T cell proliferation (GO:0050798)3.12509203
93positive regulation of interferon-alpha production (GO:0032727)3.12328927
94lymphocyte costimulation (GO:0031294)3.12078199
95positive regulation of macrophage differentiation (GO:0045651)3.11880276
96regulation of type I interferon-mediated signaling pathway (GO:0060338)3.10902608
97* interferon-gamma-mediated signaling pathway (GO:0060333)3.10624665
98positive regulation of natural killer cell mediated immunity (GO:0002717)3.10174830
99dendritic cell migration (GO:0036336)3.09523663
100myeloid dendritic cell differentiation (GO:0043011)3.09462812
101response to peptidoglycan (GO:0032494)3.06260467
102detection of molecule of bacterial origin (GO:0032490)3.05845799
103regulation of interleukin-12 biosynthetic process (GO:0045075)3.05722817
104cellular response to zinc ion (GO:0071294)3.05600595
105lymphocyte chemotaxis (GO:0048247)3.05050513
106regulation of isotype switching to IgG isotypes (GO:0048302)3.03474183
107respiratory burst (GO:0045730)3.00302005
108negative regulation of viral genome replication (GO:0045071)3.00269005
109viral life cycle (GO:0019058)2.99596032
110regulation of interferon-alpha production (GO:0032647)2.96646508
111leukocyte degranulation (GO:0043299)2.96585900
112regulation of RIG-I signaling pathway (GO:0039535)2.96247949
113mature B cell differentiation (GO:0002335)2.95519246
114positive regulation of antigen processing and presentation (GO:0002579)2.93668843
115* regulation of cell killing (GO:0031341)2.93295002
116negative thymic T cell selection (GO:0045060)2.93238333
117response to interleukin-15 (GO:0070672)2.92445346
118Peyers patch development (GO:0048541)2.91999596
119mucosal-associated lymphoid tissue development (GO:0048537)2.91999596
120negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.91298352
121regulation of dendritic cell antigen processing and presentation (GO:0002604)2.90767335
122T cell migration (GO:0072678)2.90662197
123detection of biotic stimulus (GO:0009595)2.90181685
124positive regulation of mast cell activation (GO:0033005)2.89951138
125production of molecular mediator involved in inflammatory response (GO:0002532)2.88296733
126T cell homeostasis (GO:0043029)2.86449199
127endosome to pigment granule transport (GO:0043485)2.83964645
128endosome to melanosome transport (GO:0035646)2.83964645
129nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.83917266
130neutrophil activation involved in immune response (GO:0002283)2.83839586
131regulation of T cell receptor signaling pathway (GO:0050856)2.82723734
132regulation of response to interferon-gamma (GO:0060330)2.81757971
133cellular response to interleukin-15 (GO:0071350)2.81435805
134negative T cell selection (GO:0043383)2.81156476
135regulation of natural killer cell activation (GO:0032814)2.80895145
136regulation of necrotic cell death (GO:0010939)2.80798835
137B cell receptor signaling pathway (GO:0050853)2.78679822
138regulation of respiratory burst (GO:0060263)2.77636519
139dendritic cell differentiation (GO:0097028)2.75979581
140negative regulation of nitric oxide biosynthetic process (GO:0045019)2.72396036
141cellular protein complex disassembly (GO:0043624)2.72379523
142regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.70989199
143megakaryocyte development (GO:0035855)2.70146092
144necroptotic process (GO:0070266)2.68723062
145negative regulation of necroptotic process (GO:0060546)2.68651228
146* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.68414725
147* regulation of T cell mediated cytotoxicity (GO:0001914)2.67470398
148interferon-gamma production (GO:0032609)2.65968171
149regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.65312678
150maturation of SSU-rRNA (GO:0030490)2.63314243
151natural killer cell activation (GO:0030101)2.63105318
152secretory granule organization (GO:0033363)2.62343414
153regulation of antigen processing and presentation (GO:0002577)2.59397647
154* positive regulation of T cell mediated cytotoxicity (GO:0001916)2.58428114
155lymphoid progenitor cell differentiation (GO:0002320)2.58097885
156regulation of interferon-beta biosynthetic process (GO:0045357)2.55580080
157regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.53504561
158regulation of alpha-beta T cell proliferation (GO:0046640)2.51947036
159positive regulation of natural killer cell activation (GO:0032816)2.51781358
160cellular response to exogenous dsRNA (GO:0071360)2.51575582

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.63338422
2* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.23439033
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.71005857
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.52031288
5* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.49386309
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.40903557
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.28066062
8SCL_19346495_ChIP-Seq_HPC-7_Human3.26812997
9RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.03153745
10* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.01321672
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.99870078
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.85601243
13* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.71423021
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.60315013
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.58900148
16FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.58479635
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.32941620
18* SPI1_23547873_ChIP-Seq_NB4_Human2.31080264
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30029601
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.27169354
21* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.26883816
22* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26726412
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.26302529
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.24301648
25GATA1_22025678_ChIP-Seq_K562_Human2.18594818
26* MYB_26560356_Chip-Seq_TH2_Human2.18186332
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.12048282
28SMAD_19615063_ChIP-ChIP_OVARY_Human2.11030288
29MAF_26560356_Chip-Seq_TH1_Human2.08170796
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.05093029
31VDR_21846776_ChIP-Seq_THP-1_Human2.03632058
32MYC_22102868_ChIP-Seq_BL_Human2.00007389
33E2F7_22180533_ChIP-Seq_HELA_Human1.96838826
34RUNX_20019798_ChIP-Seq_JUKART_Human1.95284521
35* MYB_26560356_Chip-Seq_TH1_Human1.93141934
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.91188262
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.90745238
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.88358652
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.85072573
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82335568
41VDR_24763502_ChIP-Seq_THP-1_Human1.82163361
42ERG_20887958_ChIP-Seq_HPC-7_Mouse1.81309876
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.79682643
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77875775
45* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.75162011
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.74535312
47UTX_26944678_Chip-Seq_JUKART_Human1.69061420
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66163785
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64749372
50GATA2_22383799_ChIP-Seq_G1ME_Mouse1.59663052
51* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57455122
52GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.55188231
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.54798304
54VDR_24787735_ChIP-Seq_THP-1_Human1.53667850
55GATA1_22383799_ChIP-Seq_G1ME_Mouse1.50786475
56GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.45073080
57E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42740836
58MYC_18555785_ChIP-Seq_MESCs_Mouse1.41512523
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40637069
60VDR_23849224_ChIP-Seq_CD4+_Human1.40471327
61PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34428654
62GABP_17652178_ChIP-ChIP_JURKAT_Human1.34238595
63MAF_26560356_Chip-Seq_TH2_Human1.32555654
64TCF7_22412390_ChIP-Seq_EML_Mouse1.27966485
65* GATA3_27048872_Chip-Seq_THYMUS_Human1.23448600
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22449747
67EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21339258
68SPI1_23127762_ChIP-Seq_K562_Human1.21027207
69PU_27001747_Chip-Seq_BMDM_Mouse1.20790217
70CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19732335
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.19570339
72CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18417023
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17757089
74RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.17694153
75FOXP3_21729870_ChIP-Seq_TREG_Human1.15487428
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14732427
77PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14429469
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12860170
79JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.09381154
80EST1_17652178_ChIP-ChIP_JURKAT_Human1.09069655
81MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06251021
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05300219
83PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04621989
84VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03125021
85* GATA3_26560356_Chip-Seq_TH2_Human1.03019784
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01986723
87GATA1_19941827_ChIP-Seq_MEL_Mouse1.01700040
88CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00201903
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99710358
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99150711
91ELK3_25401928_ChIP-Seq_HUVEC_Human0.96377576
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96334987
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95675783
94GATA2_21666600_ChIP-Seq_HMVEC_Human0.95552869
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93681739
96GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93463581
97FLI1_27457419_Chip-Seq_LIVER_Mouse0.93283525
98SMRT_27268052_Chip-Seq_Bcells_Human0.92135284
99PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90772900
100CIITA_25753668_ChIP-Seq_RAJI_Human0.90405297
101STAT1_20625510_ChIP-Seq_HELA_Human0.90100693
102ELK1_19687146_ChIP-ChIP_HELA_Human0.89669815
103TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89607799
104ETS1_20019798_ChIP-Seq_JURKAT_Human0.89246892
105* ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.87286883
106GATA3_26560356_Chip-Seq_TH1_Human0.87094503
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86837402
108CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86724131
109BCL6_27268052_Chip-Seq_Bcells_Human0.86386814
110TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86089756
111HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.85556021
112PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82852052
113* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.82353711
114CTCF_26484167_Chip-Seq_Bcells_Mouse0.81954998
115RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.81272578
116ETS1_22383799_ChIP-Seq_G1ME_Mouse0.81117737
117GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.77396031
118NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.77142545
119GATA1_19941826_ChIP-Seq_K562_Human0.76931459
120FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76531598
121P300_27268052_Chip-Seq_Bcells_Human0.75661092
122SPI1_20517297_ChIP-Seq_HL60_Human0.75207726
123PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.74274709
124GATA2_19941826_ChIP-Seq_K562_Human0.71449525
125* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.69155813
126IKZF1_21737484_ChIP-ChIP_HCT116_Human0.68436858
127PCGF2_27294783_Chip-Seq_ESCs_Mouse0.68082577
128BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.67944615
129NFE2_27457419_Chip-Seq_LIVER_Mouse0.66172436
130EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.66022948

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001835_abnormal_antigen_presentation4.37480870
2* MP0009785_altered_susceptibility_to3.50744520
3* MP0000685_abnormal_immune_system3.36375485
4* MP0005671_abnormal_response_to3.30825223
5MP0003724_increased_susceptibility_to3.08254191
6MP0002166_altered_tumor_susceptibility2.93506904
7* MP0005025_abnormal_response_to2.87014016
8MP0003763_abnormal_thymus_physiology2.83847542
9MP0002396_abnormal_hematopoietic_system2.75587521
10MP0002148_abnormal_hypersensitivity_rea2.69811380
11MP0005387_immune_system_phenotype2.69730499
12MP0001790_abnormal_immune_system2.69730499
13* MP0001800_abnormal_humoral_immune2.69326667
14MP0003436_decreased_susceptibility_to2.68935752
15* MP0005000_abnormal_immune_tolerance2.64367558
16* MP0002723_abnormal_immune_serum2.53121817
17* MP0002452_abnormal_antigen_presenting2.50415961
18* MP0002420_abnormal_adaptive_immunity2.45940077
19* MP0001819_abnormal_immune_cell2.44264895
20MP0002006_tumorigenesis2.40133212
21MP0002419_abnormal_innate_immunity2.36669198
22MP0005464_abnormal_platelet_physiology2.33125412
23* MP0002398_abnormal_bone_marrow2.25868226
24MP0006082_CNS_inflammation2.21606908
25MP0001853_heart_inflammation2.13956113
26MP0001873_stomach_inflammation2.08821261
27* MP0000716_abnormal_immune_system2.07773981
28MP0001545_abnormal_hematopoietic_system2.03281597
29MP0005397_hematopoietic_system_phenotyp2.03281597
30* MP0010155_abnormal_intestine_physiology1.96119011
31MP0002405_respiratory_system_inflammati1.90578378
32* MP0000689_abnormal_spleen_morphology1.87482662
33MP0009333_abnormal_splenocyte_physiolog1.85205571
34* MP0002722_abnormal_immune_system1.84866886
35* MP0002429_abnormal_blood_cell1.79513005
36MP0004808_abnormal_hematopoietic_stem1.75003238
37* MP0001845_abnormal_inflammatory_respons1.71193846
38MP0005174_abnormal_tail_pigmentation1.69724222
39MP0000465_gastrointestinal_hemorrhage1.63837966
40MP0005075_abnormal_melanosome_morpholog1.60620676
41* MP0008469_abnormal_protein_level1.57009884
42* MP0004947_skin_inflammation1.49452384
43MP0000490_abnormal_crypts_of1.44459817
44MP0004510_myositis1.42412190
45MP0005310_abnormal_salivary_gland1.41915818
46MP0000703_abnormal_thymus_morphology1.40604577
47MP0009764_decreased_sensitivity_to1.38242097
48MP0002254_reproductive_system_inflammat1.37642726
49MP0001533_abnormal_skeleton_physiology1.36969988
50MP0003191_abnormal_cellular_cholesterol1.31868178
51MP0003300_gastrointestinal_ulcer1.31813203
52* MP0003866_abnormal_defecation1.25634982
53MP0000858_altered_metastatic_potential1.23774110
54MP0002277_abnormal_respiratory_mucosa1.23600699
55MP0006054_spinal_hemorrhage1.23382260
56MP0002933_joint_inflammation1.23010436
57MP0009379_abnormal_foot_pigmentation1.18649148
58MP0002095_abnormal_skin_pigmentation1.18476468
59MP0000343_altered_response_to1.17806199
60MP0005058_abnormal_lysosome_morphology1.14837552
61MP0003806_abnormal_nucleotide_metabolis1.13895799
62MP0003045_fibrosis1.10753237
63MP0002132_abnormal_respiratory_system1.07804005
64MP0003183_abnormal_peptide_metabolism1.06237402
65MP0004883_abnormal_blood_vessel1.00789882
66MP0009763_increased_sensitivity_to1.00310298
67MP0003186_abnormal_redox_activity1.00203496
68MP0009278_abnormal_bone_marrow0.98980621
69MP0003656_abnormal_erythrocyte_physiolo0.98279385
70MP0004147_increased_porphyrin_level0.96210788
71MP0003448_altered_tumor_morphology0.95982905
72MP0003303_peritoneal_inflammation0.95641580
73MP0001348_abnormal_lacrimal_gland0.94902056
74* MP0002019_abnormal_tumor_incidence0.91102466
75MP0001851_eye_inflammation0.89905963
76MP0003172_abnormal_lysosome_physiology0.89061839
77MP0005164_abnormal_response_to0.87329006
78MP0005451_abnormal_body_composition0.85198519
79MP0008007_abnormal_cellular_replicative0.84005771
80MP0002138_abnormal_hepatobiliary_system0.82868953
81MP0003828_pulmonary_edema0.82190539
82MP0000569_abnormal_digit_pigmentation0.81353405
83MP0000604_amyloidosis0.80634175
84MP0002009_preneoplasia0.80165837
85MP0009840_abnormal_foam_cell0.79158654
86MP0002163_abnormal_gland_morphology0.78797074
87MP0000015_abnormal_ear_pigmentation0.78501239
88MP0003252_abnormal_bile_duct0.77258425
89MP0002998_abnormal_bone_remodeling0.76300840
90* MP0002693_abnormal_pancreas_physiology0.73381644
91MP0009765_abnormal_xenobiotic_induced0.72669397
92MP0004381_abnormal_hair_follicle0.68934940
93MP0008260_abnormal_autophagy0.68054622
94MP0003075_altered_response_to0.67980786
95MP0001765_abnormal_ion_homeostasis0.67313895
96MP0001663_abnormal_digestive_system0.67190222
97MP0003943_abnormal_hepatobiliary_system0.66149137
98MP0005319_abnormal_enzyme/_coenzyme0.64711471
99MP0003690_abnormal_glial_cell0.63842143
100MP0000249_abnormal_blood_vessel0.62905598
101MP0008004_abnormal_stomach_pH0.62203070
102MP0000598_abnormal_liver_morphology0.62118615
103MP0005584_abnormal_enzyme/coenzyme_acti0.61300087
104MP0001986_abnormal_taste_sensitivity0.60782359
105MP0004782_abnormal_surfactant_physiolog0.60759992
106MP0003795_abnormal_bone_structure0.60445394
107* MP0000609_abnormal_liver_physiology0.59446807
108MP0008872_abnormal_physiological_respon0.59349805
109MP0005390_skeleton_phenotype0.58698589
110MP0005166_decreased_susceptibility_to0.58070537
111MP0005167_abnormal_blood-brain_barrier0.57803065
112MP0005023_abnormal_wound_healing0.57748024
113MP0010352_gastrointestinal_tract_polyps0.57012068
114MP0003693_abnormal_embryo_hatching0.56981397
115MP0001764_abnormal_homeostasis0.56869615
116MP0001879_abnormal_lymphatic_vessel0.56681668
117MP0002136_abnormal_kidney_physiology0.56679513
118MP0010368_abnormal_lymphatic_system0.56650842
119MP0003638_abnormal_response/metabolism_0.55704105
120MP0000372_irregular_coat_pigmentation0.55021101
121MP0009643_abnormal_urine_homeostasis0.53234867
122MP0005379_endocrine/exocrine_gland_phen0.53053533
123MP0002876_abnormal_thyroid_physiology0.50866307
124MP0000920_abnormal_myelination0.50724168

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.43949319
2Myositis (HP:0100614)4.79086645
3Chronic otitis media (HP:0000389)4.43674121
4Recurrent abscess formation (HP:0002722)4.30270246
5Thrombocytosis (HP:0001894)4.26210823
6IgM deficiency (HP:0002850)4.25125667
7Recurrent bronchitis (HP:0002837)4.07625498
8Eczematoid dermatitis (HP:0000976)4.01075687
9Gastrointestinal infarctions (HP:0005244)3.95314307
10Recurrent bacterial skin infections (HP:0005406)3.85132701
11Aplastic anemia (HP:0001915)3.81092447
12Recurrent fungal infections (HP:0002841)3.51694854
13Abnormality of T cell physiology (HP:0011840)3.50983901
14Abnormality of the nasal mucosa (HP:0000433)3.45338218
15Orchitis (HP:0100796)3.37733989
16Nasal polyposis (HP:0100582)3.37680032
17Recurrent cutaneous fungal infections (HP:0011370)3.37395614
18Chronic mucocutaneous candidiasis (HP:0002728)3.37395614
19Petechiae (HP:0000967)3.32644041
20Abnormality of cells of the erythroid lineage (HP:0012130)3.27051784
21Abnormality of macrophages (HP:0004311)3.26859597
22Abnormality of T cells (HP:0002843)3.26276673
23Recurrent skin infections (HP:0001581)3.25246131
24Abnormal number of erythroid precursors (HP:0012131)3.22047200
25Recurrent viral infections (HP:0004429)3.20598505
26Prolonged bleeding time (HP:0003010)3.19313145
27Chest pain (HP:0100749)3.10011285
28Vasculitis (HP:0002633)3.00680700
29Retrobulbar optic neuritis (HP:0100654)3.00630897
30Optic neuritis (HP:0100653)3.00630897
31Epistaxis (HP:0000421)2.99822326
32Panhypogammaglobulinemia (HP:0003139)2.97680474
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.94809660
34Eosinophilia (HP:0001880)2.91068688
35Meningitis (HP:0001287)2.89346805
36Gangrene (HP:0100758)2.88551078
37Agammaglobulinemia (HP:0004432)2.87314098
38Autoimmune hemolytic anemia (HP:0001890)2.87215075
39Abnormality of B cell number (HP:0010975)2.83266340
40B lymphocytopenia (HP:0010976)2.83266340
41Reticulocytopenia (HP:0001896)2.82900287
42Increased IgM level (HP:0003496)2.81581562
43Lymphopenia (HP:0001888)2.81278024
44Mediastinal lymphadenopathy (HP:0100721)2.79371339
45Pulmonary embolism (HP:0002204)2.78898108
46Vacuolated lymphocytes (HP:0001922)2.78727787
47Stomatitis (HP:0010280)2.77569799
48Recurrent gram-negative bacterial infections (HP:0005420)2.76050323
49Interstitial pulmonary disease (HP:0006530)2.75406117
50Abnormality of cells of the lymphoid lineage (HP:0012140)2.75377241
51Joint swelling (HP:0001386)2.74816042
52Hypergammaglobulinemia (HP:0010702)2.74775181
53Urticaria (HP:0001025)2.72032852
54Abnormality of the pleura (HP:0002103)2.69423887
55Abnormality of T cell number (HP:0011839)2.69261579
56Autoimmune thrombocytopenia (HP:0001973)2.66922907
57Gastrointestinal stroma tumor (HP:0100723)2.66446729
58Anorexia (HP:0002039)2.65716123
59Cellulitis (HP:0100658)2.64088579
60Reduced antithrombin III activity (HP:0001976)2.62077990
61T lymphocytopenia (HP:0005403)2.61021677
62Inflammation of the large intestine (HP:0002037)2.60231193
63Spontaneous hematomas (HP:0007420)2.57372636
64Severe combined immunodeficiency (HP:0004430)2.55481252
65Gastrointestinal inflammation (HP:0004386)2.54775577
66* IgG deficiency (HP:0004315)2.54167010
67Pustule (HP:0200039)2.50673912
68Poikiloderma (HP:0001029)2.50406246
69Impaired platelet aggregation (HP:0003540)2.48379033
70Abnormal platelet function (HP:0011869)2.48379033
71Chronic diarrhea (HP:0002028)2.47627322
72Thyroiditis (HP:0100646)2.47210922
73Gingival bleeding (HP:0000225)2.45180244
74Microcytic anemia (HP:0001935)2.41168755
75Colitis (HP:0002583)2.40752729
76Hemoptysis (HP:0002105)2.39586890
77Hypoplasia of the thymus (HP:0000778)2.37297341
78Pallor (HP:0000980)2.32583428
79Purpura (HP:0000979)2.32343218
80Increased IgE level (HP:0003212)2.32153454
81Leukocytosis (HP:0001974)2.31949307
82Chronic obstructive pulmonary disease (HP:0006510)2.31741564
83Obstructive lung disease (HP:0006536)2.31741564
84Acute hepatic failure (HP:0006554)2.31060335
85Arterial thrombosis (HP:0004420)2.30645503
86Episodic fever (HP:0001954)2.30630033
87Glomerulopathy (HP:0100820)2.30024389
88Skin rash (HP:0000988)2.29613730
89Encephalitis (HP:0002383)2.29191207
90Bronchitis (HP:0012387)2.28289160
91Polyneuropathy (HP:0001271)2.27946691
92Combined immunodeficiency (HP:0005387)2.27479433
93Recurrent sinusitis (HP:0011108)2.27387834
94Abnormality of the prostate (HP:0008775)2.26239972
95Lymphoma (HP:0002665)2.26239916
96Abnormality of eosinophils (HP:0001879)2.22131871
97Chronic sinusitis (HP:0011109)2.21124069
98Muscle fiber atrophy (HP:0100295)2.21063848
99Pulmonary infiltrates (HP:0002113)2.18727749
100Type 2 muscle fiber atrophy (HP:0003554)2.18055713
101IgA deficiency (HP:0002720)2.17376517
102Type I transferrin isoform profile (HP:0003642)2.17363424
103Albinism (HP:0001022)2.15740614
104Keratitis (HP:0000491)2.15532206
105Periodontitis (HP:0000704)2.14754169
106Keratoconjunctivitis (HP:0001096)2.14331305
107Erythema (HP:0010783)2.13674488
108Keratoconjunctivitis sicca (HP:0001097)2.07300757
109Granulocytopenia (HP:0001913)2.05455317
110Neutropenia (HP:0001875)2.03516368
111Recurrent pneumonia (HP:0006532)2.02558451
112Abnormality of glycolipid metabolism (HP:0010969)2.02421167
113Abnormality of liposaccharide metabolism (HP:0010968)2.02421167
114Abnormality of glycosphingolipid metabolism (HP:0004343)2.02421167
115Vertigo (HP:0002321)2.01558512
116Gingivitis (HP:0000230)2.01538401
117Recurrent lower respiratory tract infections (HP:0002783)1.98901845
118Abnormality of the heme biosynthetic pathway (HP:0010472)1.98811111
119Basal ganglia calcification (HP:0002135)1.97876082
120Pulmonary fibrosis (HP:0002206)1.95818119
121Abnormality of the pericardium (HP:0001697)1.95457381
122Alveolar cell carcinoma (HP:0006519)1.95201673
123Arthralgia (HP:0002829)1.94123759
124Hepatosplenomegaly (HP:0001433)1.88535612
125Increased serum ferritin (HP:0003281)1.85359692
126Thrombophlebitis (HP:0004418)1.83357952
127Neoplasm of the tracheobronchial system (HP:0100552)1.83281889
128Osteomyelitis (HP:0002754)1.82688085
129Systemic lupus erythematosus (HP:0002725)1.80921614
130Skin ulcer (HP:0200042)1.80794940
131Abnormality of the endocardium (HP:0004306)1.80276477
132Sepsis (HP:0100806)1.79543169
133Amaurosis fugax (HP:0100576)1.79398072

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.56877264
2KIT3.37279814
3NME22.94702237
4TXK2.90875755
5TBK12.86046931
6IKBKE2.72129442
7JAK32.67052572
8FLT32.56059570
9TYK22.46796211
10KDR2.46542363
11TEC2.40723412
12MAP3K122.23596348
13ZAP702.20248238
14BMPR22.20130336
15BTK2.16504921
16MAP3K142.10299658
17IRAK41.99129119
18BLK1.95334125
19PIM21.93857838
20TGFBR21.86033950
21CSF1R1.81644758
22TGFBR11.78496678
23ERN11.77654217
24IKBKB1.71246912
25TNIK1.66842029
26FGFR41.62484804
27NLK1.60363535
28SYK1.57239223
29JAK11.48647841
30MAP2K31.46474685
31STK161.45974343
32MUSK1.39545329
33LCK1.32522017
34ACVR1B1.28827935
35LRRK21.28473410
36TIE11.18815821
37TAOK31.15791044
38LYN1.15432494
39GRK71.14829941
40CDK191.14274141
41IRAK31.11667973
42ITK1.11128233
43EEF2K1.08628689
44MATK1.07372195
45MYLK1.06057759
46RIPK41.05061421
47FRK1.04518154
48RPS6KA41.02534556
49FGR1.01058575
50PRKCQ0.99307530
51TLK10.97888810
52HCK0.96970027
53PIM10.87286549
54FGFR30.86907913
55ADRBK20.86724409
56CHUK0.83291689
57MAP2K60.83250601
58SCYL20.83219144
59EIF2AK10.82583983
60MARK30.82372965
61STK100.82143154
62FES0.78712208
63BCKDK0.78710760
64DYRK30.78449706
65RPS6KB20.76318409
66PRKG20.75427630
67MAPKAPK30.75382655
68MAP3K130.75243230
69VRK10.74043091
70GRK60.73622893
71JAK20.72519227
72TNK20.72281766
73MST40.69515269
74CSK0.69323346
75EIF2AK30.68208690
76PDK10.66250014
77PRPF4B0.66166383
78CAMKK20.65784030
79WEE10.64051310
80FYN0.62138002
81MAP3K110.61784915
82MAP3K10.60621238
83MAPKAPK50.59780675
84PTK2B0.56596103
85MAPK110.56248502
86TESK20.54616925
87RAF10.52654657
88PKN20.51731982
89NEK90.51453968
90TAOK10.49665845
91EIF2AK20.47300459
92DAPK20.46699195
93MAP4K20.45906268
94EPHA30.45514863
95CAMKK10.44290903
96PAK40.43793458
97IGF1R0.43397147
98MAPK40.41111386
99CDK40.40612981
100ILK0.39701346
101PIK3CG0.39373633
102YES10.38800315
103PRKCD0.38326441
104GRK10.38273766
105MAP3K50.38204166
106MAP3K30.37972600
107EPHB10.37723830
108TAOK20.37106636
109IRAK10.37075175
110MAPK70.36775869
111RPS6KA50.35601700
112ABL10.32785021
113DAPK10.32740418
114MAPK120.32114436
115CAMK10.31765158
116CDK80.31719900
117MAP3K70.31346580
118MAPKAPK20.31162653
119BRSK20.31013124
120OXSR10.30985990
121GRK50.30930875
122NUAK10.30877851
123HIPK20.29525350
124EGFR0.29134908
125TRPM70.29022192
126SIK30.27847296
127DYRK1B0.27740602
128PDPK10.27476154
129MAP3K20.25598032
130INSR0.23339739
131PASK0.22787242
132ADRBK10.22007786
133MAP2K20.21763453
134CLK10.21744767

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.91131765
2Ribosome_Homo sapiens_hsa030103.40370082
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.85804794
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.60480603
5Leishmaniasis_Homo sapiens_hsa051402.54798016
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.46681091
7Allograft rejection_Homo sapiens_hsa053302.42145824
8Measles_Homo sapiens_hsa051622.39165636
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.37349743
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.32331179
11Hematopoietic cell lineage_Homo sapiens_hsa046402.09722867
12DNA replication_Homo sapiens_hsa030302.05408169
13* Antigen processing and presentation_Homo sapiens_hsa046121.92310039
14Herpes simplex infection_Homo sapiens_hsa051681.86799862
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.84374855
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.81489496
17B cell receptor signaling pathway_Homo sapiens_hsa046621.75163901
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.69477665
19Graft-versus-host disease_Homo sapiens_hsa053321.66703112
20Osteoclast differentiation_Homo sapiens_hsa043801.64304410
21Asthma_Homo sapiens_hsa053101.58780728
22Malaria_Homo sapiens_hsa051441.55828616
23Legionellosis_Homo sapiens_hsa051341.55075337
24Caffeine metabolism_Homo sapiens_hsa002321.51968365
25Staphylococcus aureus infection_Homo sapiens_hsa051501.50698875
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49947960
27Pertussis_Homo sapiens_hsa051331.45106007
28Proteasome_Homo sapiens_hsa030501.38984449
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.38809663
30Influenza A_Homo sapiens_hsa051641.36177931
31Base excision repair_Homo sapiens_hsa034101.34160812
32Other glycan degradation_Homo sapiens_hsa005111.32688085
33Toxoplasmosis_Homo sapiens_hsa051451.31246788
34T cell receptor signaling pathway_Homo sapiens_hsa046601.31070617
35Shigellosis_Homo sapiens_hsa051311.23308703
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21224860
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17084260
38Sulfur relay system_Homo sapiens_hsa041221.15204999
39Mismatch repair_Homo sapiens_hsa034301.15110256
40Autoimmune thyroid disease_Homo sapiens_hsa053201.15067275
41Phagosome_Homo sapiens_hsa041451.13670842
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13125547
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.11369397
44Tuberculosis_Homo sapiens_hsa051521.10519329
45Apoptosis_Homo sapiens_hsa042101.10032762
46Acute myeloid leukemia_Homo sapiens_hsa052211.07675426
47TNF signaling pathway_Homo sapiens_hsa046681.07248700
48Pyrimidine metabolism_Homo sapiens_hsa002401.05572257
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03137882
50Homologous recombination_Homo sapiens_hsa034401.02951741
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01965188
52Hepatitis B_Homo sapiens_hsa051610.98724104
53Protein export_Homo sapiens_hsa030600.96822850
54Folate biosynthesis_Homo sapiens_hsa007900.96641853
55Viral myocarditis_Homo sapiens_hsa054160.91160402
56Salmonella infection_Homo sapiens_hsa051320.91048561
57Platelet activation_Homo sapiens_hsa046110.90344006
58African trypanosomiasis_Homo sapiens_hsa051430.86309312
59Nucleotide excision repair_Homo sapiens_hsa034200.85778479
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84681661
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.84489041
62p53 signaling pathway_Homo sapiens_hsa041150.80291724
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79956455
64Chemokine signaling pathway_Homo sapiens_hsa040620.79785146
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79400551
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.76375243
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74833190
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74774578
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74622911
70Hepatitis C_Homo sapiens_hsa051600.74024174
71RNA polymerase_Homo sapiens_hsa030200.70564561
72Pentose phosphate pathway_Homo sapiens_hsa000300.66307544
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65478267
74Spliceosome_Homo sapiens_hsa030400.65121541
75N-Glycan biosynthesis_Homo sapiens_hsa005100.64307596
76Non-homologous end-joining_Homo sapiens_hsa034500.63738677
77Rheumatoid arthritis_Homo sapiens_hsa053230.62508770
78Epstein-Barr virus infection_Homo sapiens_hsa051690.62230440
79Type I diabetes mellitus_Homo sapiens_hsa049400.60450936
80Lysosome_Homo sapiens_hsa041420.60307636
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59639315
82Regulation of autophagy_Homo sapiens_hsa041400.58046580
83Collecting duct acid secretion_Homo sapiens_hsa049660.52555233
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51344141
85HTLV-I infection_Homo sapiens_hsa051660.49920151
86RNA degradation_Homo sapiens_hsa030180.49044033
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.48875529
88Viral carcinogenesis_Homo sapiens_hsa052030.47217575
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46297068
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45717601
91Arachidonic acid metabolism_Homo sapiens_hsa005900.43650226
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41908951
93Endocytosis_Homo sapiens_hsa041440.41809066
94Complement and coagulation cascades_Homo sapiens_hsa046100.40380672
95Systemic lupus erythematosus_Homo sapiens_hsa053220.40242050
96Prolactin signaling pathway_Homo sapiens_hsa049170.39744536
97ABC transporters_Homo sapiens_hsa020100.38463587
98Thyroid cancer_Homo sapiens_hsa052160.38386060
99Pancreatic cancer_Homo sapiens_hsa052120.37245562
100Linoleic acid metabolism_Homo sapiens_hsa005910.34794744
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32945282
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32932475
103Galactose metabolism_Homo sapiens_hsa000520.32181437
104Purine metabolism_Homo sapiens_hsa002300.31869692
105Small cell lung cancer_Homo sapiens_hsa052220.31147519
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30338309
107Chronic myeloid leukemia_Homo sapiens_hsa052200.30139384
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28294003
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28034148
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.27596786
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27237782
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.27198602
113Nitrogen metabolism_Homo sapiens_hsa009100.26319927
114Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.25682431
115Non-small cell lung cancer_Homo sapiens_hsa052230.24507642
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24139676
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24092608
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.23870416
119VEGF signaling pathway_Homo sapiens_hsa043700.17892794
120Oxidative phosphorylation_Homo sapiens_hsa001900.16588734
121Dorso-ventral axis formation_Homo sapiens_hsa043200.16013018
122Ether lipid metabolism_Homo sapiens_hsa005650.12356418
123Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.10843141
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.10264148
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.07228019
126Insulin resistance_Homo sapiens_hsa049310.06197783
127FoxO signaling pathway_Homo sapiens_hsa040680.04991621
128Phototransduction_Homo sapiens_hsa047440.04341195
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.04142926
130MAPK signaling pathway_Homo sapiens_hsa040100.03233349
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.02562998

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