AXL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of actin filament depolymerization (GO:0030836)6.12679188
2negative regulation of axon extension involved in axon guidance (GO:0048843)5.55161802
3arginine catabolic process (GO:0006527)5.19863932
4actin filament depolymerization (GO:0030042)5.13516959
5cell adhesion mediated by integrin (GO:0033627)5.03429007
6negative regulation of axon guidance (GO:1902668)4.83760028
7protein heterotetramerization (GO:0051290)4.80802009
8wound healing, spreading of epidermal cells (GO:0035313)4.78838765
9regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.77537424
10chondrocyte proliferation (GO:0035988)4.75939536
11collagen fibril organization (GO:0030199)4.74413073
12protein heterotrimerization (GO:0070208)4.51064910
13muscle organ morphogenesis (GO:0048644)4.41422115
14negative regulation of nitric-oxide synthase activity (GO:0051001)4.40304812
15endodermal cell differentiation (GO:0035987)4.38815609
16positive regulation of protein autophosphorylation (GO:0031954)4.35888941
17regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.33272081
18proteasome assembly (GO:0043248)4.31114330
19regulation of metalloenzyme activity (GO:0048552)4.23946183
20positive regulation of macrophage activation (GO:0043032)4.19378960
21skin morphogenesis (GO:0043589)4.16882456
22cullin deneddylation (GO:0010388)4.15243141
23negative regulation of fatty acid transport (GO:2000192)4.11900077
24positive regulation of vesicle fusion (GO:0031340)4.09898708
25positive regulation of fibroblast migration (GO:0010763)4.08204343
26positive regulation of endothelial cell apoptotic process (GO:2000353)4.00653874
27basement membrane organization (GO:0071711)3.93477340
28* apoptotic cell clearance (GO:0043277)3.91038479
29sequestering of extracellular ligand from receptor (GO:0035581)3.88917246
30protein deneddylation (GO:0000338)3.88286623
31regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.86658681
32positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.80716198
33wound healing, spreading of cells (GO:0044319)3.80169499
34plasma membrane repair (GO:0001778)3.79782423
35neuron projection extension involved in neuron projection guidance (GO:1902284)3.78442495
36axon extension involved in axon guidance (GO:0048846)3.78442495
37nucleotide-sugar biosynthetic process (GO:0009226)3.62819837
38glomerular basement membrane development (GO:0032836)3.60676661
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.59049647
40protein retention in ER lumen (GO:0006621)3.48382803
41collagen metabolic process (GO:0032963)3.47679133
42positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.47517085
43membrane assembly (GO:0071709)3.45175360
44female gonad development (GO:0008585)3.44335593
45regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.44123892
46collagen catabolic process (GO:0030574)3.40237421
47positive regulation of macrophage cytokine production (GO:0060907)3.39406122
48stress fiber assembly (GO:0043149)3.35820514
49maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.34995343
50lymphangiogenesis (GO:0001946)3.33962855
51UDP-N-acetylglucosamine metabolic process (GO:0006047)3.32832307
52regulation of monocyte chemotaxis (GO:0090025)3.28918720
53multicellular organismal macromolecule metabolic process (GO:0044259)3.25695877
54regulation of interleukin-8 secretion (GO:2000482)3.24632747
55vascular endothelial growth factor signaling pathway (GO:0038084)3.21582845
56regulation of macrophage cytokine production (GO:0010935)3.18161601
57response to gravity (GO:0009629)3.16378590
58type B pancreatic cell proliferation (GO:0044342)3.15860923
59regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.14410500
60positive regulation of interleukin-8 secretion (GO:2000484)3.14229735
61sprouting angiogenesis (GO:0002040)3.13845030
62negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.13563235
63muscle cell cellular homeostasis (GO:0046716)3.12954483
64lipopolysaccharide biosynthetic process (GO:0009103)3.11681625
65multicellular organismal catabolic process (GO:0044243)3.10819297
66extracellular matrix disassembly (GO:0022617)3.10270137
67regulation of axon extension involved in axon guidance (GO:0048841)3.09838888
68negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.09677406
69embryonic cranial skeleton morphogenesis (GO:0048701)3.05875660
70multicellular organismal metabolic process (GO:0044236)3.05673746
71pericardium development (GO:0060039)3.03139317
72negative regulation of JAK-STAT cascade (GO:0046426)3.02266036
73activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.00609620
74positive regulation of monocyte chemotaxis (GO:0090026)3.00369380
75regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.99771215
76positive regulation of cardiac muscle hypertrophy (GO:0010613)2.99539843
77positive regulation of muscle hypertrophy (GO:0014742)2.99539843
78face morphogenesis (GO:0060325)2.98610847
79cell migration involved in heart development (GO:0060973)2.96646205
80negative regulation of smooth muscle cell migration (GO:0014912)2.94271530
81glomerular visceral epithelial cell development (GO:0072015)2.94040893
82regulation of actin filament depolymerization (GO:0030834)2.93868868
83regulation of axon guidance (GO:1902667)2.92499259
84dermatan sulfate biosynthetic process (GO:0030208)2.92348830
85epithelial cell-cell adhesion (GO:0090136)2.92326052
86low-density lipoprotein particle clearance (GO:0034383)2.91457217
87regulation of Rac protein signal transduction (GO:0035020)2.90924756
88ganglion development (GO:0061548)2.89575301
89regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.89544697
90substrate-dependent cell migration (GO:0006929)2.86715391
91positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.86682099
92positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.86058842
93modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.84091756
94positive regulation by organism of defense response of other organism involved in symbiotic interact2.84091756
95modulation by symbiont of host immune response (GO:0052553)2.84091756
96positive regulation by symbiont of host defense response (GO:0052509)2.84091756
97modulation by symbiont of host defense response (GO:0052031)2.84091756
98modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.84091756
99cellular response to vitamin (GO:0071295)2.82855571
100negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.82328240
101regulation of plasminogen activation (GO:0010755)2.82086404
102negative regulation of stem cell proliferation (GO:2000647)2.80667974
103retina vasculature morphogenesis in camera-type eye (GO:0061299)2.80583218
104bone trabecula formation (GO:0060346)2.79151763
105positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.78586542
106renal filtration (GO:0097205)2.78279481
107regulation of protein autophosphorylation (GO:0031952)2.76386256
108regulation of membrane protein ectodomain proteolysis (GO:0051043)2.76320042
109cellular response to vitamin D (GO:0071305)2.75423982
110regulation of mononuclear cell migration (GO:0071675)2.73758116
111cell-substrate junction assembly (GO:0007044)2.73657941
112response to fluid shear stress (GO:0034405)2.72568422
113mesenchymal-epithelial cell signaling (GO:0060638)2.69918323
114positive regulation of interferon-alpha production (GO:0032727)2.69307631
115inositol phosphate-mediated signaling (GO:0048016)2.68361139
116fibrinolysis (GO:0042730)2.68339038
117dermatan sulfate metabolic process (GO:0030205)2.68108985
118ventricular cardiac muscle cell development (GO:0055015)2.67692839
119regulation of homotypic cell-cell adhesion (GO:0034110)2.67592015
120anterior/posterior axis specification, embryo (GO:0008595)2.67531352
121platelet-derived growth factor receptor signaling pathway (GO:0048008)2.67527680
122myoblast migration (GO:0051451)2.67329894
123negative chemotaxis (GO:0050919)2.66913452
124regulation of integrin activation (GO:0033623)2.64878979
125fibroblast migration (GO:0010761)2.63315389
126barbed-end actin filament capping (GO:0051016)2.63136628
127regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.63008861
128muscle cell migration (GO:0014812)2.62559207
129smooth muscle tissue development (GO:0048745)2.62419409
130regulation of type B pancreatic cell apoptotic process (GO:2000674)2.62121499
131cell migration involved in sprouting angiogenesis (GO:0002042)2.61378988
132positive regulation of protein depolymerization (GO:1901881)2.60088502
133integrin-mediated signaling pathway (GO:0007229)2.58989192
134metanephric mesenchyme development (GO:0072075)2.58974372
135negative regulation of skeletal muscle tissue development (GO:0048642)2.58905208
136endothelial cell morphogenesis (GO:0001886)2.58576500
137membrane raft organization (GO:0031579)2.58408977
138positive regulation of endothelial cell migration (GO:0010595)2.58134474
139regulation of organ formation (GO:0003156)2.55603749
140regulation of tight junction assembly (GO:2000810)2.55341032
141positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.54422338
142platelet aggregation (GO:0070527)2.53424184
143glomerular epithelial cell development (GO:0072310)2.53059762
144protein localization to endosome (GO:0036010)2.52932433
145cellular response to zinc ion (GO:0071294)2.52837195
146response to laminar fluid shear stress (GO:0034616)2.52478880
147negative regulation of nitric oxide biosynthetic process (GO:0045019)2.51807218
148positive regulation of blood vessel endothelial cell migration (GO:0043536)2.51372727
149arginine metabolic process (GO:0006525)2.51097792
150negative regulation of chondrocyte differentiation (GO:0032331)2.51075022
151positive regulation of fibroblast proliferation (GO:0048146)2.50686636
152protein localization to cell surface (GO:0034394)2.50656949
153organ induction (GO:0001759)2.50624351
154membrane budding (GO:0006900)2.50599117
155hemidesmosome assembly (GO:0031581)2.50533485
156negative regulation of embryonic development (GO:0045992)2.50521090
157phagocytosis, recognition (GO:0006910)2.50355280
158heterotypic cell-cell adhesion (GO:0034113)2.49501100
159* substrate adhesion-dependent cell spreading (GO:0034446)2.49405168
160regulation of cholesterol storage (GO:0010885)2.48924857
161hippo signaling (GO:0035329)2.48063666
162regulation of interferon-alpha production (GO:0032647)2.48004201
163regulation of integrin-mediated signaling pathway (GO:2001044)2.47752819
164regulation of interferon-beta biosynthetic process (GO:0045357)2.46596391
165fibril organization (GO:0097435)2.45648904
166extracellular matrix organization (GO:0030198)2.44315355
167glomerular filtration (GO:0003094)2.43959716
168extracellular structure organization (GO:0043062)2.43435322
169mesodermal cell differentiation (GO:0048333)2.42775355
170cortical actin cytoskeleton organization (GO:0030866)2.41751487
171kidney mesenchyme development (GO:0072074)2.41192703
172extracellular matrix assembly (GO:0085029)2.40568969
173cellular response to amino acid stimulus (GO:0071230)2.39362497
174positive regulation of p38MAPK cascade (GO:1900745)2.38871659
175endocardial cushion development (GO:0003197)2.38831036
176neutrophil activation involved in immune response (GO:0002283)2.38611252
177dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.38430374
178cell-matrix adhesion (GO:0007160)2.37392811
179gonadal mesoderm development (GO:0007506)2.37327841

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.14271673
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.79769489
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.42016636
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.73286451
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.66482063
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.25651505
7CLOCK_20551151_ChIP-Seq_293T_Human2.97313955
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.91819963
9TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.80923141
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.77558965
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.65259048
12* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.62903035
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.61780943
14ELK1_19687146_ChIP-ChIP_HELA_Human2.61518234
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.51747437
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.50438804
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.49370723
18CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.44478991
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.42051747
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32643864
21CJUN_26792858_Chip-Seq_BT549_Human2.25393295
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.25053194
23GBX2_23144817_ChIP-Seq_PC3_Human2.17843093
24GABP_17652178_ChIP-ChIP_JURKAT_Human2.07024709
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.05932902
26CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.04117822
27* ELK3_25401928_ChIP-Seq_HUVEC_Human2.00623423
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.99442614
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.96273299
30SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.89732684
31SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.89732684
32* IRF8_27001747_Chip-Seq_BMDM_Mouse1.87968175
33ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.87376382
34BRD4_25478319_ChIP-Seq_HGPS_Human1.85409032
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.84327043
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84024773
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83478286
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81045301
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79410758
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.78590092
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.74298263
42SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71376272
43NRF2_20460467_ChIP-Seq_MEFs_Mouse1.70939351
44NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.70939351
45MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.67841949
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.67493662
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.67070832
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64373101
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64056676
50STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.63169789
51EWS_26573619_Chip-Seq_HEK293_Human1.62593272
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61065007
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60336661
54EP300_21415370_ChIP-Seq_HL-1_Mouse1.59187539
55EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.58306310
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57699334
57ESR1_21235772_ChIP-Seq_MCF-7_Human1.57418553
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.56913841
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.56622381
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.55957726
61P300_27058665_Chip-Seq_ZR-75-30cells_Human1.55289373
62* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55286624
63* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54245471
64* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.53551560
65SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.52202478
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.51467360
67P300_19829295_ChIP-Seq_ESCs_Human1.51356097
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51235013
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51169697
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.49020071
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48189974
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48118547
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47705597
74KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46851939
75TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46708711
76ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46240601
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44018203
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43722102
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.43505609
80* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43385928
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.42722414
82FOXO3_23340844_ChIP-Seq_DLD1_Human1.42364599
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.41175292
84* SOX2_20726797_ChIP-Seq_SW620_Human1.40867854
85ATF3_27146783_Chip-Seq_COLON_Human1.39727186
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38423916
87TP53_16413492_ChIP-PET_HCT116_Human1.37544269
88FUS_26573619_Chip-Seq_HEK293_Human1.37250039
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37205073
90* UBF1/2_26484160_Chip-Seq_HMECs_Human1.34180745
91SMC1_22415368_ChIP-Seq_MEFs_Mouse1.32047892
92BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31309179
93RACK7_27058665_Chip-Seq_MCF-7_Human1.29114258
94SMAD4_21799915_ChIP-Seq_A2780_Human1.28819485
95SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26405687
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.23833617
97SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.23379556
98FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23182248
99TBX20_22080862_ChIP-Seq_HEART_Mouse1.23159125
100TBX20_22328084_ChIP-Seq_HEART_Mouse1.23159125
101CRX_20693478_ChIP-Seq_RETINA_Mouse1.23127665
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22422430
103* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.21400407
104SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20383822
105KDM2B_26808549_Chip-Seq_DND41_Human1.20109141
106NANOG_18555785_Chip-Seq_ESCs_Mouse1.19048399
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18387164
108KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15437927
109STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15017954
110* ZNF274_21170338_ChIP-Seq_K562_Hela1.13475167
111VDR_24787735_ChIP-Seq_THP-1_Human1.13386179
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13138668
113* TP53_18474530_ChIP-ChIP_U2OS_Human1.10961687
114* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10306188
115STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09969765
116LXR_22292898_ChIP-Seq_THP-1_Human1.09379898
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08815934
118UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08808619
119* TP53_22127205_ChIP-Seq_IMR90_Human1.07253746
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06697098
121TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06564211
122CDX2_22108803_ChIP-Seq_LS180_Human1.06103863
123FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.05100674
124VDR_22108803_ChIP-Seq_LS180_Human1.04685560
125HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02830260
126NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02601512
127ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02278006
128SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00277561
129ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98157154
130JUN_21703547_ChIP-Seq_K562_Human0.97939174
131MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97876240
132P53_22387025_ChIP-Seq_ESCs_Mouse0.97340976
133PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96864380
134NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.96824947
135BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95974387
136PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95555003
137FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95520117
138KLF5_25053715_ChIP-Seq_YYC3_Human0.95064048
139VDR_24763502_ChIP-Seq_THP-1_Human0.95040011
140E2F1_18555785_Chip-Seq_ESCs_Mouse0.94961387
141SOX17_20123909_ChIP-Seq_XEN_Mouse0.94470859
142NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94111470
143* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.93897346
144RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93605307
145MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.93367203
146STAT3_23295773_ChIP-Seq_U87_Human0.93348198
147CMYC_18555785_Chip-Seq_ESCs_Mouse0.93142747
148* TP53_23651856_ChIP-Seq_MEFs_Mouse0.93023631
149BCAT_22108803_ChIP-Seq_LS180_Human0.92691410
150EST1_17652178_ChIP-ChIP_JURKAT_Human0.92403085
151VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92263803
152KDM2B_26808549_Chip-Seq_K562_Human0.90972709
153TP63_23658742_ChIP-Seq_EP156T_Human0.88822589
154* TCF7_22412390_ChIP-Seq_EML_Mouse0.88742776
155* SRF_21415370_ChIP-Seq_HL-1_Mouse0.88060407
156SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87931630
157HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87411239
158PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87210700
159SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87115573
160OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86284109
161MAF_26560356_Chip-Seq_TH1_Human0.85352193
162SPI1_23127762_ChIP-Seq_K562_Human0.84850586
163SOX2_19829295_ChIP-Seq_ESCs_Human0.84560316
164NANOG_19829295_ChIP-Seq_ESCs_Human0.84560316
165AR_25329375_ChIP-Seq_VCAP_Human0.83347770
166UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82878206
167STAT3_18555785_Chip-Seq_ESCs_Mouse0.80187408
168ER_23166858_ChIP-Seq_MCF-7_Human0.80089974

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.92177250
2MP0003705_abnormal_hypodermis_morpholog4.47720522
3MP0009780_abnormal_chondrocyte_physiolo4.40318072
4MP0005275_abnormal_skin_tensile4.30721259
5MP0005503_abnormal_tendon_morphology3.43294668
6MP0003279_aneurysm3.42718958
7MP0001958_emphysema3.07566479
8MP0005623_abnormal_meninges_morphology2.86895469
9MP0004272_abnormal_basement_membrane2.63209446
10MP0003566_abnormal_cell_adhesion2.51441829
11MP0003941_abnormal_skin_development2.48578314
12MP0010352_gastrointestinal_tract_polyps2.40666892
13MP0005360_urolithiasis2.26344957
14MP0003091_abnormal_cell_migration2.19740598
15MP0000749_muscle_degeneration2.15886896
16MP0009384_cardiac_valve_regurgitation2.00414596
17MP0005257_abnormal_intraocular_pressure1.97212215
18MP0005023_abnormal_wound_healing1.90813321
19MP0000733_abnormal_muscle_development1.88604274
20MP0006054_spinal_hemorrhage1.86767771
21MP0002060_abnormal_skin_morphology1.74947693
22MP0003045_fibrosis1.73046203
23MP0005076_abnormal_cell_differentiation1.67518831
24MP0003300_gastrointestinal_ulcer1.66667655
25MP0003303_peritoneal_inflammation1.66237082
26MP0005595_abnormal_vascular_smooth1.65964512
27MP0002295_abnormal_pulmonary_circulatio1.60762325
28MP0005084_abnormal_gallbladder_morpholo1.57781035
29MP0005508_abnormal_skeleton_morphology1.57233438
30MP0000767_abnormal_smooth_muscle1.53610101
31MP0002877_abnormal_melanocyte_morpholog1.52317879
32MP0000750_abnormal_muscle_regeneration1.49225276
33MP0003436_decreased_susceptibility_to1.47465590
34MP0000372_irregular_coat_pigmentation1.42801060
35MP0001533_abnormal_skeleton_physiology1.42206332
36MP0003755_abnormal_palate_morphology1.40882174
37MP0003448_altered_tumor_morphology1.39344897
38MP0000762_abnormal_tongue_morphology1.37156808
39MP0001243_abnormal_dermal_layer1.37008880
40MP0005171_absent_coat_pigmentation1.36366447
41MP0002168_other_aberrant_phenotype1.35985405
42MP0002998_abnormal_bone_remodeling1.34410818
43MP0005390_skeleton_phenotype1.32982084
44MP0004036_abnormal_muscle_relaxation1.30725773
45MP0003252_abnormal_bile_duct1.29870472
46MP0010368_abnormal_lymphatic_system1.28117594
47MP0009278_abnormal_bone_marrow1.27591947
48MP0010030_abnormal_orbit_morphology1.26561242
49MP0004510_myositis1.24886136
50MP0002896_abnormal_bone_mineralization1.24111381
51MP0005165_increased_susceptibility_to1.23452511
52MP0003806_abnormal_nucleotide_metabolis1.22166579
53MP0000343_altered_response_to1.21574577
54MP0000858_altered_metastatic_potential1.19037639
55MP0001299_abnormal_eye_distance/1.17392568
56MP0002234_abnormal_pharynx_morphology1.17013808
57MP0010386_abnormal_urinary_bladder1.14390373
58MP0000538_abnormal_urinary_bladder1.13432790
59MP0005058_abnormal_lysosome_morphology1.12913991
60MP0001542_abnormal_bone_strength1.12347017
61MP0003942_abnormal_urinary_system1.11182581
62MP0004484_altered_response_of1.11134215
63MP0002933_joint_inflammation1.10684887
64MP0004947_skin_inflammation1.10059925
65MP0001835_abnormal_antigen_presentation1.07601280
66MP0002108_abnormal_muscle_morphology1.07077900
67MP0008775_abnormal_heart_ventricle1.06473872
68MP0001348_abnormal_lacrimal_gland1.05731765
69MP0003937_abnormal_limbs/digits/tail_de1.02309747
70MP0003385_abnormal_body_wall1.01412686
71MP0009053_abnormal_anal_canal1.00734068
72MP0005164_abnormal_response_to1.00151828
73MP0003724_increased_susceptibility_to0.99549376
74MP0001879_abnormal_lymphatic_vessel0.97364021
75MP0006082_CNS_inflammation0.97203413
76MP0000013_abnormal_adipose_tissue0.94270233
77MP0009697_abnormal_copulation0.93869884
78* MP0002419_abnormal_innate_immunity0.92204005
79MP0002148_abnormal_hypersensitivity_rea0.92165022
80MP0003828_pulmonary_edema0.90722356
81MP0000751_myopathy0.90412077
82MP0003075_altered_response_to0.90183929
83MP0004087_abnormal_muscle_fiber0.89918728
84MP0002928_abnormal_bile_duct0.89172001
85* MP0002128_abnormal_blood_circulation0.87757361
86MP0003186_abnormal_redox_activity0.87191099
87MP0003795_abnormal_bone_structure0.87014832
88MP0005187_abnormal_penis_morphology0.85944072
89MP0000432_abnormal_head_morphology0.84991492
90MP0000569_abnormal_digit_pigmentation0.84955037
91* MP0001614_abnormal_blood_vessel0.84906841
92MP0005193_abnormal_anterior_eye0.84064664
93MP0002006_tumorigenesis0.83534997
94MP0002751_abnormal_autonomic_nervous0.83441304
95MP0004084_abnormal_cardiac_muscle0.83213542
96MP0003453_abnormal_keratinocyte_physiol0.83199002
97MP0002115_abnormal_skeleton_extremities0.81899508
98MP0000685_abnormal_immune_system0.80044842
99MP0002160_abnormal_reproductive_system0.79439022
100MP0002113_abnormal_skeleton_development0.79435742
101MP0002177_abnormal_outer_ear0.79359926
102MP0009250_abnormal_appendicular_skeleto0.78711080
103MP0010307_abnormal_tumor_latency0.78693265
104MP0001915_intracranial_hemorrhage0.77684122
105MP0004134_abnormal_chest_morphology0.77503978
106MP0002282_abnormal_trachea_morphology0.77065115
107MP0000516_abnormal_urinary_system0.76773813
108MP0005367_renal/urinary_system_phenotyp0.76773813
109MP0005395_other_phenotype0.76278921
110MP0000428_abnormal_craniofacial_morphol0.76156736
111MP0002166_altered_tumor_susceptibility0.74481425
112* MP0005000_abnormal_immune_tolerance0.74477362
113MP0005620_abnormal_muscle_contractility0.74280841
114MP0002932_abnormal_joint_morphology0.73700478
115MP0008007_abnormal_cellular_replicative0.73681101
116MP0000163_abnormal_cartilage_morphology0.73646101
117MP0003191_abnormal_cellular_cholesterol0.73522626
118MP0002114_abnormal_axial_skeleton0.72784893
119MP0003115_abnormal_respiratory_system0.72096611
120MP0000249_abnormal_blood_vessel0.71916646
121MP0004883_abnormal_blood_vessel0.71746581
122MP0004130_abnormal_muscle_cell0.70986611
123MP0001853_heart_inflammation0.70910358
124MP0004185_abnormal_adipocyte_glucose0.70832989
125MP0009840_abnormal_foam_cell0.70157009
126MP0001881_abnormal_mammary_gland0.69924541
127MP0005408_hypopigmentation0.69593161
128MP0010630_abnormal_cardiac_muscle0.69298534
129MP0003950_abnormal_plasma_membrane0.69264988
130MP0004808_abnormal_hematopoietic_stem0.69260930
131MP0001175_abnormal_lung_morphology0.68892326
132MP0005197_abnormal_uvea_morphology0.67429493
133MP0000427_abnormal_hair_cycle0.67269903
134MP0000759_abnormal_skeletal_muscle0.67002913
135MP0003935_abnormal_craniofacial_develop0.66729376
136MP0000534_abnormal_ureter_morphology0.66454337
137MP0005375_adipose_tissue_phenotype0.66415913
138MP0000003_abnormal_adipose_tissue0.66100020
139MP0002925_abnormal_cardiovascular_devel0.66049263
140MP0008004_abnormal_stomach_pH0.65864144
141MP0005388_respiratory_system_phenotype0.65718901
142MP0002133_abnormal_respiratory_system0.65718901
143MP0005330_cardiomyopathy0.65712292
144MP0006138_congestive_heart_failure0.64418662
145MP0000613_abnormal_salivary_gland0.62827161
146MP0002109_abnormal_limb_morphology0.61417788
147MP0002938_white_spotting0.60977031

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.99897516
2Protrusio acetabuli (HP:0003179)6.92774784
3Aortic dissection (HP:0002647)4.58253378
4Ankle contracture (HP:0006466)4.58110437
5Peritonitis (HP:0002586)4.43202035
6Cerebral aneurysm (HP:0004944)4.37997038
7Shallow orbits (HP:0000586)4.28410896
8Atrophic scars (HP:0001075)4.08908117
9Aortic aneurysm (HP:0004942)3.90598844
10Dilatation of the ascending aorta (HP:0005111)3.84558415
11Delayed gross motor development (HP:0002194)3.81504051
12Sensory axonal neuropathy (HP:0003390)3.79019499
13Soft skin (HP:0000977)3.72665740
14Reduced subcutaneous adipose tissue (HP:0003758)3.71401049
15Short middle phalanx of the 5th finger (HP:0004220)3.65936108
16Increased connective tissue (HP:0009025)3.60122028
17Nemaline bodies (HP:0003798)3.56916445
18Cervical subluxation (HP:0003308)3.53498991
19Fragile skin (HP:0001030)3.45628134
20Vertebral compression fractures (HP:0002953)3.45592280
21Osteolytic defects of the hand bones (HP:0009699)3.44787842
22Osteolytic defects of the phalanges of the hand (HP:0009771)3.44787842
23Amniotic constriction ring (HP:0009775)3.39701588
24Abnormality of placental membranes (HP:0011409)3.39701588
25Bell-shaped thorax (HP:0001591)3.24462355
26Mitral valve prolapse (HP:0001634)3.24273897
27Bladder diverticulum (HP:0000015)3.23562255
28Broad metatarsal (HP:0001783)3.23268995
29Popliteal pterygium (HP:0009756)3.19369070
30Abnormality of dentin (HP:0010299)3.06058869
31Type 1 muscle fiber predominance (HP:0003803)3.05448897
32Spinal rigidity (HP:0003306)3.05331957
33Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.04344109
34Coronal craniosynostosis (HP:0004440)3.03321556
35Wormian bones (HP:0002645)3.02906377
36Genu recurvatum (HP:0002816)3.02277423
37Wrist flexion contracture (HP:0001239)2.97486891
38Microglossia (HP:0000171)2.97296004
39Aplasia of the musculature (HP:0100854)2.93791795
40Abnormality of the phalanges of the 2nd finger (HP:0009541)2.90586444
41Neonatal short-limb short stature (HP:0008921)2.87329092
42Biconcave vertebral bodies (HP:0004586)2.83168362
43Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.82661852
44Blue sclerae (HP:0000592)2.79283797
45Abnormality of the proximal phalanges of the hand (HP:0009834)2.76454755
46Follicular hyperkeratosis (HP:0007502)2.74476467
47Type 2 muscle fiber atrophy (HP:0003554)2.73548246
48Vascular tortuosity (HP:0004948)2.68347505
49Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.67361746
50Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.66806866
51Flared iliac wings (HP:0002869)2.66421147
52Short nail (HP:0001799)2.61907815
53Fibular aplasia (HP:0002990)2.61616293
54Abnormality of proline metabolism (HP:0010907)2.57400676
55Hydroxyprolinuria (HP:0003080)2.57400676
56Increased density of long bones (HP:0006392)2.56623342
57Entropion (HP:0000621)2.56365028
58Cardiovascular calcification (HP:0011915)2.51369766
59Arterial tortuosity (HP:0005116)2.50571005
60Upper limb amyotrophy (HP:0009129)2.50003801
61Distal upper limb amyotrophy (HP:0007149)2.50003801
62Aneurysm (HP:0002617)2.49554067
63Hypoplastic ischia (HP:0003175)2.49451520
64Muscle fiber inclusion bodies (HP:0100299)2.45048258
65Glucose intolerance (HP:0000833)2.44940079
66Myocardial infarction (HP:0001658)2.42811428
67Bifid tongue (HP:0010297)2.42616283
68Metaphyseal dysplasia (HP:0100255)2.41112203
69Camptodactyly of toe (HP:0001836)2.40125559
70Abnormality of the phalanges of the 5th finger (HP:0004213)2.37828564
71Spinal cord lesions (HP:0100561)2.34952168
72Syringomyelia (HP:0003396)2.34952168
73Elbow flexion contracture (HP:0002987)2.34620120
74Abnormalities of placenta or umbilical cord (HP:0001194)2.32291213
75Hyperextensible skin (HP:0000974)2.32284877
76Abnormality of the umbilical cord (HP:0010881)2.28306810
77Hypoplastic scapulae (HP:0000882)2.27518829
78Aplasia/Hypoplasia of the scapulae (HP:0006713)2.27518829
79Thin bony cortex (HP:0002753)2.27343400
80Hyporeflexia of lower limbs (HP:0002600)2.25177122
81Abnormality of the peritoneum (HP:0002585)2.24246975
82Mildly elevated creatine phosphokinase (HP:0008180)2.21051882
83Disproportionate short-trunk short stature (HP:0003521)2.20051901
84Difficulty climbing stairs (HP:0003551)2.19942345
85Fatigable weakness (HP:0003473)2.18265783
86Abnormality of the neuromuscular junction (HP:0003398)2.18265783
87Narrow palate (HP:0000189)2.17563575
88Hypoplastic iliac wings (HP:0002866)2.17274426
89Abnormality of the acetabulum (HP:0003170)2.15643568
90Slender build (HP:0001533)2.14066281
91Increased number of teeth (HP:0011069)2.13745728
92Rhizomelia (HP:0008905)2.13387468
93Muscle fiber atrophy (HP:0100295)2.12689503
94Upper limb muscle weakness (HP:0003484)2.12676808
95Abnormality of the frontal sinuses (HP:0002687)2.12242367
96Abnormal delivery (HP:0001787)2.11622063
97Mitral regurgitation (HP:0001653)2.11125640
98Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.10891142
99Delayed closure of the anterior fontanelle (HP:0001476)2.10841100
100Increased variability in muscle fiber diameter (HP:0003557)2.10772537
101Scapular winging (HP:0003691)2.10199616
102Spondylolisthesis (HP:0003302)2.09249554
103Bowel diverticulosis (HP:0005222)2.08184150
104Abnormality of carpal bone ossification (HP:0006257)2.06938355
105Albinism (HP:0001022)2.06432959
106Distal lower limb amyotrophy (HP:0008944)2.06251947
107Abnormality of the ischium (HP:0003174)2.05348596
108Radial bowing (HP:0002986)2.04304775
109Broad face (HP:0000283)2.03710811
110Ulnar bowing (HP:0003031)2.01622503
111Hamartoma of the eye (HP:0010568)2.00902698
112Abnormal auditory evoked potentials (HP:0006958)2.00669198
113Abnormality of the 2nd finger (HP:0004100)2.00576346
114Joint laxity (HP:0001388)1.99943864
115Rough bone trabeculation (HP:0100670)1.99416269
116Tibial bowing (HP:0002982)1.99348095
117Small hand (HP:0200055)1.98898814
118Overgrowth (HP:0001548)1.98774584
119Ectopia lentis (HP:0001083)1.98237029
120Striae distensae (HP:0001065)1.98120550
121Absent frontal sinuses (HP:0002688)1.97642783
122Eczematoid dermatitis (HP:0000976)1.97521118
123Flexion contracture of toe (HP:0005830)1.97116341
124Joint contractures involving the joints of the feet (HP:0100492)1.97116341
125Deviation of the hallux (HP:0010051)1.95927189
126Aplasia/Hypoplasia of the tongue (HP:0010295)1.95488580
127Hand muscle atrophy (HP:0009130)1.95413875
128Hypoplasia of the odontoid process (HP:0003311)1.95238531
129Bone cyst (HP:0012062)1.94967749
130Hematochezia (HP:0002573)1.94911604
131Adrenal hypoplasia (HP:0000835)1.94699180
132Abnormality of the calcaneus (HP:0008364)1.94675851
133Hallux valgus (HP:0001822)1.91974018
134Abnormality of the wing of the ilium (HP:0011867)1.91847150
135Muscle fiber splitting (HP:0003555)1.90998731
136Venous abnormality (HP:0002624)1.90622458
137Mesomelia (HP:0003027)1.90246187
138Round ear (HP:0100830)1.89933522
139Abnormality of skeletal muscle fiber size (HP:0012084)1.89815456
140Increased corneal curvature (HP:0100692)1.88232858
141Keratoconus (HP:0000563)1.88232858
142Gowers sign (HP:0003391)1.88165892
143Infantile muscular hypotonia (HP:0008947)1.87363648
144Ovoid vertebral bodies (HP:0003300)1.85572393
145Stillbirth (HP:0003826)1.85428265
146Aortic regurgitation (HP:0001659)1.81464925
147Aplasia/Hypoplasia involving the musculature (HP:0001460)1.81228891
148Absent phalangeal crease (HP:0006109)1.80775818
149Posterior subcapsular cataract (HP:0007787)1.80756538
150Femoral bowing (HP:0002980)1.80549118
151Mesangial abnormality (HP:0001966)1.80153171
152Bowed forearm bones (HP:0003956)1.77045509
153Bowing of the arm (HP:0006488)1.77045509
154Pterygium (HP:0001059)1.76254723
155Aplasia/Hypoplasia of the fibula (HP:0006492)1.76017308
156Abnormality of the phalanges of the hallux (HP:0010057)1.75477632
157Wide anterior fontanel (HP:0000260)1.75443062
158Achilles tendon contracture (HP:0001771)1.74678588
159Rectal prolapse (HP:0002035)1.73880701
160Aortic valve stenosis (HP:0001650)1.73799790
161Renal duplication (HP:0000075)1.73772503
162Decreased skull ossification (HP:0004331)1.73136898
163Delayed cranial suture closure (HP:0000270)1.72815090
164Buphthalmos (HP:0000557)1.72664116
165Thick nail (HP:0001805)1.71359704
166Mitral stenosis (HP:0001718)1.71132661
167Short 4th metacarpal (HP:0010044)1.71031087
168Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.71031087
169Coxa vara (HP:0002812)1.68304322
170Nonimmune hydrops fetalis (HP:0001790)1.67801687
171Lower limb amyotrophy (HP:0007210)1.65692619
172Fused cervical vertebrae (HP:0002949)1.65635593
173Knee flexion contracture (HP:0006380)1.63276693
174Tarsal synostosis (HP:0008368)1.63263188
175Long toe (HP:0010511)1.62615257
176Broad ribs (HP:0000885)1.61728213

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.13864811
2TRIM284.66274064
3TRIB34.48437197
4SIK33.91174497
5MAP3K123.38283985
6DDR23.07701384
7BCR3.05439106
8ERN13.02967989
9PDGFRA2.82474876
10MUSK2.70485213
11PKN22.58632853
12EIF2AK32.49138770
13NUAK12.23975946
14BMX2.23375491
15RIPK12.21460129
16PRKD32.21169917
17LATS12.20433991
18EIF2AK12.06143613
19PLK22.04555949
20TRPM71.89954679
21TGFBR21.88162082
22PAK21.77767287
23LRRK21.75052973
24RPS6KA41.72255269
25SIK11.67733410
26LATS21.67063356
27DMPK1.65867817
28PTK61.65146634
29MOS1.59999325
30ACVR1B1.59206845
31TBK11.58684535
32TESK11.54236628
33EPHB21.51098444
34NEK91.50127658
35PTK21.48918050
36PAK41.41992569
37EPHB11.40920598
38BMPR1B1.35108842
39PLK31.30861582
40STK31.30240461
41JAK11.30108951
42MAP3K141.28183051
43EPHA21.26628907
44JAK31.23965108
45PDGFRB1.23662049
46PIM21.23459911
47TYK21.22918992
48VRK21.22291293
49STK101.20301874
50BUB11.19593693
51EEF2K1.17250407
52PTK2B1.16044215
53FER1.12990741
54MAP4K21.08277970
55MAP3K101.07287578
56ABL21.07212514
57MYLK1.05080145
58PAK31.04373800
59CAMK1D1.04325189
60GRK71.02491497
61MST41.01724887
62MKNK21.01390865
63CSK0.98046966
64STK160.96257833
65LIMK10.96064910
66MET0.94388109
67NEK10.94262130
68ERBB40.93995361
69KIT0.93396521
70ILK0.91751998
71EPHA30.90502050
72MELK0.88335193
73ROCK10.88298439
74FGFR40.85247083
75TNIK0.85171718
76FGFR10.84177434
77MINK10.82352739
78PIK3CG0.80976704
79MKNK10.80695596
80MTOR0.80122811
81MST1R0.79086053
82MAP2K10.78940688
83KSR10.78652862
84RIPK40.77995315
85EIF2AK20.77892520
86AKT30.76334261
87NME20.74914550
88CDK60.74688425
89IKBKB0.72266293
90ERBB30.71983290
91GSK3A0.71806875
92PRKCE0.70901528
93ADRBK10.69632422
94STK390.67952143
95MAP2K30.67461392
96BRSK20.66193041
97FGFR30.65443191
98CHUK0.64519807
99MAP3K30.64215269
100MAPKAPK50.62053743
101CDK120.61819217
102MAPK130.61425771
103CAMK2D0.59670490
104SCYL20.59658883
105MAPKAPK30.59571090
106DAPK30.58489275
107CLK10.57601891
108CDK80.57601404
109STK38L0.57153756
110PIK3CA0.54178875
111PRKD10.54112874
112PRKCH0.53988704
113TAF10.53306821
114BMPR20.53256424
115* INSR0.52883829
116PRKD20.52447502
117PBK0.52432061
118ABL10.52356874
119ROCK20.51811098
120FGR0.51441124
121RET0.51337190
122BLK0.51245616
123KDR0.49371793
124EGFR0.48298863
125TGFBR10.47825273
126FLT30.47607493
127IKBKE0.47233452
128CAMK1G0.47169758
129ZAP700.46614778
130MAP3K80.46600927
131PAK10.46144170
132PRKCI0.45872124
133DAPK10.45846764
134STK380.44347175
135MAP4K10.44217609
136CAMKK10.44128068
137SRC0.42751541
138GRK10.42043841
139BRSK10.42006112
140PDK20.40532455
141NTRK10.40502765
142RAF10.38606270
143MAPKAPK20.37973260
144CDC42BPA0.36937050
145PAK60.36349991
146DYRK1B0.35240012
147LMTK20.34304451
148* HCK0.31773144
149JAK20.30842979
150PRKG20.30600134
151FRK0.30359199
152CDK180.29462814
153CHEK20.28747499
154PLK10.27609480
155GRK50.26065490
156ADRBK20.24904141
157WNK30.23320657

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.36427560
2Protein export_Homo sapiens_hsa030603.61385162
3ECM-receptor interaction_Homo sapiens_hsa045123.12871394
4Focal adhesion_Homo sapiens_hsa045102.54859767
5Vitamin B6 metabolism_Homo sapiens_hsa007502.52035650
6Malaria_Homo sapiens_hsa051442.50667149
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.35499957
8Amoebiasis_Homo sapiens_hsa051462.26242491
9AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.18551680
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.16463119
11Leishmaniasis_Homo sapiens_hsa051402.15095178
12Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.14018937
13Proteoglycans in cancer_Homo sapiens_hsa052052.11171397
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.99312056
15Basal transcription factors_Homo sapiens_hsa030221.98819124
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.98147471
17Small cell lung cancer_Homo sapiens_hsa052221.86173827
18Viral myocarditis_Homo sapiens_hsa054161.85191079
19Sulfur metabolism_Homo sapiens_hsa009201.85091919
20SNARE interactions in vesicular transport_Homo sapiens_hsa041301.81278542
21Adherens junction_Homo sapiens_hsa045201.80417438
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.77502840
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69579306
24Shigellosis_Homo sapiens_hsa051311.68772274
25Toxoplasmosis_Homo sapiens_hsa051451.68717792
26Osteoclast differentiation_Homo sapiens_hsa043801.65678912
27Salmonella infection_Homo sapiens_hsa051321.64501104
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.63240091
29Hedgehog signaling pathway_Homo sapiens_hsa043401.62644417
30TNF signaling pathway_Homo sapiens_hsa046681.61580011
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.58168255
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.57840366
33Dilated cardiomyopathy_Homo sapiens_hsa054141.57644038
34Phagosome_Homo sapiens_hsa041451.56947398
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.55357700
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.55185107
37Propanoate metabolism_Homo sapiens_hsa006401.54624810
38Chronic myeloid leukemia_Homo sapiens_hsa052201.54560207
39RNA polymerase_Homo sapiens_hsa030201.54202839
40Bladder cancer_Homo sapiens_hsa052191.52398845
41Pertussis_Homo sapiens_hsa051331.52150760
42Legionellosis_Homo sapiens_hsa051341.48432931
43Tuberculosis_Homo sapiens_hsa051521.47611709
44Nucleotide excision repair_Homo sapiens_hsa034201.45840762
45Lysosome_Homo sapiens_hsa041421.42962155
46Regulation of actin cytoskeleton_Homo sapiens_hsa048101.39323343
47Non-homologous end-joining_Homo sapiens_hsa034501.38582280
48Staphylococcus aureus infection_Homo sapiens_hsa051501.33173389
49One carbon pool by folate_Homo sapiens_hsa006701.32383983
50MicroRNAs in cancer_Homo sapiens_hsa052061.31991860
51Vibrio cholerae infection_Homo sapiens_hsa051101.31876504
52TGF-beta signaling pathway_Homo sapiens_hsa043501.30054006
53Pyrimidine metabolism_Homo sapiens_hsa002401.27047102
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.27013902
55Protein digestion and absorption_Homo sapiens_hsa049741.26952922
56Apoptosis_Homo sapiens_hsa042101.25160171
57NF-kappa B signaling pathway_Homo sapiens_hsa040641.20019292
58Glutathione metabolism_Homo sapiens_hsa004801.18727634
59Pancreatic cancer_Homo sapiens_hsa052121.18029197
60Platelet activation_Homo sapiens_hsa046111.17413791
61Rheumatoid arthritis_Homo sapiens_hsa053231.16444293
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14249503
63Fatty acid elongation_Homo sapiens_hsa000621.12839050
64Wnt signaling pathway_Homo sapiens_hsa043101.06040949
65Glycosaminoglycan degradation_Homo sapiens_hsa005311.06031423
66PI3K-Akt signaling pathway_Homo sapiens_hsa041511.05389032
67Hepatitis B_Homo sapiens_hsa051610.99681580
68Measles_Homo sapiens_hsa051620.99043710
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98375637
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98204702
71Hippo signaling pathway_Homo sapiens_hsa043900.96663867
72Selenocompound metabolism_Homo sapiens_hsa004500.96165081
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95750019
74Complement and coagulation cascades_Homo sapiens_hsa046100.93583409
75Melanoma_Homo sapiens_hsa052180.92665286
76Influenza A_Homo sapiens_hsa051640.92541070
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91703606
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90822502
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.90691898
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89065527
81Fanconi anemia pathway_Homo sapiens_hsa034600.87518205
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.87152233
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86862141
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86417857
85Homologous recombination_Homo sapiens_hsa034400.85897181
86Glioma_Homo sapiens_hsa052140.83712571
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.81102384
88p53 signaling pathway_Homo sapiens_hsa041150.80985042
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80656829
90Graft-versus-host disease_Homo sapiens_hsa053320.80356784
91Folate biosynthesis_Homo sapiens_hsa007900.79053806
92Rap1 signaling pathway_Homo sapiens_hsa040150.78119063
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.78037191
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77475170
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77308781
96HIF-1 signaling pathway_Homo sapiens_hsa040660.77254732
97Caffeine metabolism_Homo sapiens_hsa002320.76384243
98HTLV-I infection_Homo sapiens_hsa051660.76241589
99Antigen processing and presentation_Homo sapiens_hsa046120.75834682
100N-Glycan biosynthesis_Homo sapiens_hsa005100.75334304
101Pathways in cancer_Homo sapiens_hsa052000.74404091
102Chemokine signaling pathway_Homo sapiens_hsa040620.73921329
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73617777
104Mineral absorption_Homo sapiens_hsa049780.72316711
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71531358
106VEGF signaling pathway_Homo sapiens_hsa043700.70637452
107Prostate cancer_Homo sapiens_hsa052150.68946704
108B cell receptor signaling pathway_Homo sapiens_hsa046620.68487558
109RNA degradation_Homo sapiens_hsa030180.67475840
110Hematopoietic cell lineage_Homo sapiens_hsa046400.67078246
111Viral carcinogenesis_Homo sapiens_hsa052030.67073749
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.66463566
113Tight junction_Homo sapiens_hsa045300.66138965
114Acute myeloid leukemia_Homo sapiens_hsa052210.66067827
115Purine metabolism_Homo sapiens_hsa002300.64813590
116Notch signaling pathway_Homo sapiens_hsa043300.64388655
117Prion diseases_Homo sapiens_hsa050200.64177267
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63865723
119Endocytosis_Homo sapiens_hsa041440.62239144
120Insulin resistance_Homo sapiens_hsa049310.61522094
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.61264968
122Renal cell carcinoma_Homo sapiens_hsa052110.60670413
123Other glycan degradation_Homo sapiens_hsa005110.57385935
124Prolactin signaling pathway_Homo sapiens_hsa049170.56994626
125Melanogenesis_Homo sapiens_hsa049160.55512722
126Dorso-ventral axis formation_Homo sapiens_hsa043200.54701942
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53337853
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52965101
129Hepatitis C_Homo sapiens_hsa051600.52582891
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52143095
131African trypanosomiasis_Homo sapiens_hsa051430.51676300
132Oocyte meiosis_Homo sapiens_hsa041140.50291300
133Axon guidance_Homo sapiens_hsa043600.48925698
134Herpes simplex infection_Homo sapiens_hsa051680.48462074
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48240333
136RNA transport_Homo sapiens_hsa030130.47908689
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.47894582
138Colorectal cancer_Homo sapiens_hsa052100.47296462
139Allograft rejection_Homo sapiens_hsa053300.46208707
140Renin-angiotensin system_Homo sapiens_hsa046140.45752884
141Sphingolipid metabolism_Homo sapiens_hsa006000.45338895
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44227869
143Endometrial cancer_Homo sapiens_hsa052130.44157248
144PPAR signaling pathway_Homo sapiens_hsa033200.44066839
145Basal cell carcinoma_Homo sapiens_hsa052170.43254040
146mTOR signaling pathway_Homo sapiens_hsa041500.43153053
147Cell cycle_Homo sapiens_hsa041100.42467069
148Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41606413
149Sphingolipid signaling pathway_Homo sapiens_hsa040710.40822231
150Pyruvate metabolism_Homo sapiens_hsa006200.40504822
151Calcium signaling pathway_Homo sapiens_hsa040200.38974587
152Pentose phosphate pathway_Homo sapiens_hsa000300.38607872
153Phototransduction_Homo sapiens_hsa047440.36258011
154Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35307572
155Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34950443
156Salivary secretion_Homo sapiens_hsa049700.34135530
157Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33664712
158Metabolic pathways_Homo sapiens_hsa011000.31931797
159Galactose metabolism_Homo sapiens_hsa000520.29044395
160Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27321649
161Gap junction_Homo sapiens_hsa045400.26150001
162Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.25866771
163Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24470479
164Ras signaling pathway_Homo sapiens_hsa040140.23566176
165Chemical carcinogenesis_Homo sapiens_hsa052040.23391836

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