AXDND1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.88128707
2epithelial cilium movement (GO:0003351)9.76694879
3piRNA metabolic process (GO:0034587)9.72167579
4sperm-egg recognition (GO:0035036)9.51703704
5acrosome reaction (GO:0007340)9.29769175
6acrosome assembly (GO:0001675)9.23879756
7binding of sperm to zona pellucida (GO:0007339)8.62564810
8cilium movement (GO:0003341)8.60727842
9cell wall macromolecule metabolic process (GO:0044036)8.60350368
10cell wall macromolecule catabolic process (GO:0016998)8.60350368
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.59648948
12cell-cell recognition (GO:0009988)8.52713089
13plasma membrane fusion (GO:0045026)8.45431642
14motile cilium assembly (GO:0044458)8.42334623
15male meiosis (GO:0007140)8.14922371
16spermatid development (GO:0007286)8.13643279
17reproduction (GO:0000003)7.98879603
18regulation of cilium movement (GO:0003352)7.32232147
19synaptonemal complex organization (GO:0070193)7.19393715
20response to pheromone (GO:0019236)7.19306403
21synaptonemal complex assembly (GO:0007130)6.89859537
22single fertilization (GO:0007338)6.76290524
23DNA methylation involved in gamete generation (GO:0043046)6.30467739
24sperm capacitation (GO:0048240)6.21422545
25protein targeting to Golgi (GO:0000042)6.12205905
26establishment of protein localization to Golgi (GO:0072600)6.04541847
27rRNA methylation (GO:0031167)5.99528219
28male meiosis I (GO:0007141)5.77924833
29phosphatidylethanolamine biosynthetic process (GO:0006646)5.73512754
30retrograde transport, vesicle recycling within Golgi (GO:0000301)5.65791693
31fertilization (GO:0009566)5.63336249
32phosphatidylethanolamine metabolic process (GO:0046337)5.33190199
33ventricular system development (GO:0021591)5.30103646
34chromosome organization involved in meiosis (GO:0070192)5.29277293
35spermatogenesis (GO:0007283)5.28257535
36male gamete generation (GO:0048232)5.26616968
37microtubule depolymerization (GO:0007019)5.25251225
38sexual reproduction (GO:0019953)5.25168659
39rRNA modification (GO:0000154)5.02233750
40cellular ketone body metabolic process (GO:0046950)5.02128432
41gamete generation (GO:0007276)4.86173952
42organic cation transport (GO:0015695)4.83532697
43meiotic nuclear division (GO:0007126)4.83354781
44negative regulation of inclusion body assembly (GO:0090084)4.77380657
45DNA synthesis involved in DNA repair (GO:0000731)4.74274310
46germ cell development (GO:0007281)4.70013638
47cellular process involved in reproduction in multicellular organism (GO:0022412)4.62782430
48meiosis I (GO:0007127)4.62470954
49histone H3-K9 demethylation (GO:0033169)4.60112911
50meiotic cell cycle (GO:0051321)4.59859455
51RNA destabilization (GO:0050779)4.52919842
52protein localization to Golgi apparatus (GO:0034067)4.48479805
53seminiferous tubule development (GO:0072520)4.46872508
54monoubiquitinated protein deubiquitination (GO:0035520)4.45352996
55regulation of Rab GTPase activity (GO:0032313)4.42215057
56positive regulation of Rab GTPase activity (GO:0032851)4.42215057
57ketone body metabolic process (GO:1902224)4.39107446
58protein localization to cilium (GO:0061512)4.17873346
59nuclear pore complex assembly (GO:0051292)4.07058843
60cell recognition (GO:0008037)3.83420401
61calcium ion-dependent exocytosis (GO:0017156)3.82585782
62axoneme assembly (GO:0035082)3.81890686
63multicellular organismal reproductive process (GO:0048609)3.79268383
64synapsis (GO:0007129)3.77441858
65regulation of inclusion body assembly (GO:0090083)3.75782371
66microtubule severing (GO:0051013)3.72218875
67regulation of microtubule-based movement (GO:0060632)3.64944849
68regulation of transcription involved in cell fate commitment (GO:0060850)3.64742163
69left/right pattern formation (GO:0060972)3.64650625
70genitalia morphogenesis (GO:0035112)3.61463741
71chromatin silencing (GO:0006342)3.58039187
72meiotic cell cycle process (GO:1903046)3.56399289
73centriole assembly (GO:0098534)3.49653596
74intraciliary transport (GO:0042073)3.49136163
75peptidyl-threonine dephosphorylation (GO:0035970)3.46573578
76microtubule nucleation (GO:0007020)3.35606847
77gene silencing by RNA (GO:0031047)3.32544607
78pore complex assembly (GO:0046931)3.31432566
79centriole replication (GO:0007099)3.30360102
80regulation of meiosis I (GO:0060631)3.28578046
81protein polyglutamylation (GO:0018095)3.27121574
82cilium organization (GO:0044782)3.26903934
83coenzyme catabolic process (GO:0009109)3.26819210
84nuclear pore organization (GO:0006999)3.26339207
85positive regulation of meiosis (GO:0045836)3.24139376
86cilium assembly (GO:0042384)3.15391890
87multicellular organismal movement (GO:0050879)3.12965407
88musculoskeletal movement (GO:0050881)3.12965407
89regulation of spindle checkpoint (GO:0090231)3.10013907
90multicellular organismal development (GO:0007275)3.08582483
91carnitine transmembrane transport (GO:1902603)3.07163696
92resolution of meiotic recombination intermediates (GO:0000712)3.05923359
93positive regulation of meiotic cell cycle (GO:0051446)3.04808200
94single strand break repair (GO:0000012)3.00983265
95regulation of centriole replication (GO:0046599)3.00576645
96carnitine transport (GO:0015879)2.99240301
97amino-acid betaine transport (GO:0015838)2.99240301
98spermatid nucleus differentiation (GO:0007289)2.99027634
99left/right axis specification (GO:0070986)2.98627712
100gene silencing (GO:0016458)2.96786677
101DNA packaging (GO:0006323)2.96442292
102glomerular visceral epithelial cell development (GO:0072015)2.95707385
103Golgi to endosome transport (GO:0006895)2.95078641
104glomerular epithelial cell development (GO:0072310)2.94029018
105DNA conformation change (GO:0071103)2.91484439
106mitotic sister chromatid cohesion (GO:0007064)2.89955003
107nucleoside diphosphate phosphorylation (GO:0006165)2.89365864
108protein K11-linked deubiquitination (GO:0035871)2.84137765
109cellular component assembly involved in morphogenesis (GO:0010927)2.82215871
110nucleus organization (GO:0006997)2.78912054
111chromosome condensation (GO:0030261)2.77353196
112glycerol ether metabolic process (GO:0006662)2.75392923
113cilium morphogenesis (GO:0060271)2.75097492
114reciprocal meiotic recombination (GO:0007131)2.74026872
115reciprocal DNA recombination (GO:0035825)2.74026872
116sister chromatid cohesion (GO:0007062)2.73106672
117microtubule-based movement (GO:0007018)2.72710320
118cellular response to gamma radiation (GO:0071480)2.66747399
119DNA alkylation (GO:0006305)2.65581420
120DNA methylation (GO:0006306)2.65581420
121histone exchange (GO:0043486)2.58490266
122ether metabolic process (GO:0018904)2.53785102
123meiotic chromosome segregation (GO:0045132)2.53594758
124regulation of podosome assembly (GO:0071801)2.47483769
125negative regulation of skeletal muscle tissue development (GO:0048642)2.46942741
126microtubule polymerization or depolymerization (GO:0031109)2.45817294
127lactate metabolic process (GO:0006089)2.45452108
128histone H3-K9 methylation (GO:0051567)2.40560538
129cilium or flagellum-dependent cell motility (GO:0001539)14.0908509
130fusion of sperm to egg plasma membrane (GO:0007342)11.0999833
131sperm motility (GO:0030317)10.9668069
132axonemal dynein complex assembly (GO:0070286)10.1163605

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.59348494
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.17834849
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.20454389
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.86744893
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.49848821
6EZH2_22144423_ChIP-Seq_EOC_Human3.22730387
7FLI1_27457419_Chip-Seq_LIVER_Mouse3.15948196
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.95996362
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.88500083
10NFE2_27457419_Chip-Seq_LIVER_Mouse2.39351250
11SUZ12_27294783_Chip-Seq_NPCs_Mouse2.35245443
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.33160347
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.30296718
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23750017
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.23492811
16PCGF2_27294783_Chip-Seq_NPCs_Mouse2.16715244
17ERA_21632823_ChIP-Seq_H3396_Human2.09932887
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.07837911
19VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.00803208
20KAP1_22055183_ChIP-Seq_ESCs_Mouse1.92709584
21EZH2_27294783_Chip-Seq_NPCs_Mouse1.90342428
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.90331334
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88983032
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87583791
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.86734238
26TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.81576313
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81383856
28VDR_22108803_ChIP-Seq_LS180_Human1.80288985
29EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.78623746
30EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.76446063
31SMAD4_21741376_ChIP-Seq_EPCs_Human1.74503421
32STAT1_17558387_ChIP-Seq_HELA_Human1.74409304
33AUTS2_25519132_ChIP-Seq_293T-REX_Human1.72638353
34STAT3_18555785_Chip-Seq_ESCs_Mouse1.70953765
35NANOG_20526341_ChIP-Seq_ESCs_Human1.70633518
36P53_22387025_ChIP-Seq_ESCs_Mouse1.70173824
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.69739073
38RAC3_21632823_ChIP-Seq_H3396_Human1.68830078
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.68403089
40MYC_19829295_ChIP-Seq_ESCs_Human1.68205870
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.67748694
42NANOG_18555785_Chip-Seq_ESCs_Mouse1.67331354
43AR_25329375_ChIP-Seq_VCAP_Human1.66411495
44TAL1_26923725_Chip-Seq_HPCs_Mouse1.65754578
45EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.63442373
46GATA1_26923725_Chip-Seq_HPCs_Mouse1.63199136
47ELF1_20517297_ChIP-Seq_JURKAT_Human1.61288837
48OCT4_18555785_Chip-Seq_ESCs_Mouse1.61134025
49CRX_20693478_ChIP-Seq_RETINA_Mouse1.60776850
50IRF8_21731497_ChIP-ChIP_J774_Mouse1.55640885
51RUNX1_27457419_Chip-Seq_LIVER_Mouse1.55035227
52P300_18555785_Chip-Seq_ESCs_Mouse1.53796534
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53685698
54TAF2_19829295_ChIP-Seq_ESCs_Human1.53612999
55SUZ12_18555785_Chip-Seq_ESCs_Mouse1.52073951
56KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.51912888
57E2F1_18555785_Chip-Seq_ESCs_Mouse1.51369673
58OCT4_20526341_ChIP-Seq_ESCs_Human1.50664515
59P300_19829295_ChIP-Seq_ESCs_Human1.50183911
60ESRRB_18555785_Chip-Seq_ESCs_Mouse1.49345073
61CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.49276799
62CMYC_18555785_Chip-Seq_ESCs_Mouse1.48023790
63* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.47827868
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47825315
65* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.47120694
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46493769
67CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.46244448
68OCT4_21477851_ChIP-Seq_ESCs_Mouse1.46061781
69PU1_27457419_Chip-Seq_LIVER_Mouse1.45739369
70YY1_22570637_ChIP-Seq_MALME-3M_Human1.45697969
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45569065
72KLF4_18555785_Chip-Seq_ESCs_Mouse1.45138767
73NMYC_18555785_Chip-Seq_ESCs_Mouse1.44634172
74HNFA_21074721_ChIP-Seq_CACO-2_Human1.43543590
75RBPJ_21746931_ChIP-Seq_IB4_Human1.42743092
76ERG_20517297_ChIP-Seq_VCAP_Human1.42630313
77STAT3_23295773_ChIP-Seq_U87_Human1.42430908
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.42123614
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.41548539
80CBX2_22325352_ChIP-Seq_293T-Rex_Human1.41287598
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41137658
82CBP_20019798_ChIP-Seq_JUKART_Human1.41137658
83E2F1_20622854_ChIP-Seq_HELA_Human1.41101403
84RNF2_27304074_Chip-Seq_NSC_Mouse1.40405410
85TDRD3_21172665_ChIP-Seq_MCF-7_Human1.37837019
86SOX2_18555785_Chip-Seq_ESCs_Mouse1.37609289
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37551135
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37551135
89ZFX_18555785_Chip-Seq_ESCs_Mouse1.37408131
90CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.36555925
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36447709
92KDM2B_26808549_Chip-Seq_REH_Human1.36274016
93GATA3_21878914_ChIP-Seq_MCF-7_Human1.36187503
94DROSHA_22980978_ChIP-Seq_HELA_Human1.35971131
95RUNX2_22187159_ChIP-Seq_PCA_Human1.35139805
96BCL6_27268052_Chip-Seq_Bcells_Human1.33635419
97SMAD1_18555785_Chip-Seq_ESCs_Mouse1.33300295
98PHF8_20622854_ChIP-Seq_HELA_Human1.32465509
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.31706773
100TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.31679884
101CTCF_18555785_Chip-Seq_ESCs_Mouse1.31440560
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30971068
103ER_23166858_ChIP-Seq_MCF-7_Human1.30038433
104SMAD4_21799915_ChIP-Seq_A2780_Human1.29558301
105SMC4_20622854_ChIP-Seq_HELA_Human1.26407277
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.25066513
107HOXB7_26014856_ChIP-Seq_BT474_Human1.24987201
108POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24496351
109CTCF_20526341_ChIP-Seq_ESCs_Human1.23836378
110SMAD3_21741376_ChIP-Seq_ESCs_Human1.23428748
111SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.22694432
112PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.22043292
113GATA3_21867929_ChIP-Seq_TH1_Mouse1.21300290
114P300_27268052_Chip-Seq_Bcells_Human1.20960776
115FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20574199
116P68_20966046_ChIP-Seq_HELA_Human1.20154720
117BCOR_27268052_Chip-Seq_Bcells_Human1.20149787
118PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19713940
119PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.19165047
120ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18235308
121PRDM14_20953172_ChIP-Seq_ESCs_Human1.18016540
122CEBPB_22108803_ChIP-Seq_LS180_Human1.17792615
123NANOG_19829295_ChIP-Seq_ESCs_Human1.17645212
124SOX2_19829295_ChIP-Seq_ESCs_Human1.17645212
125WDR5_24793694_ChIP-Seq_LNCAP_Human1.17217459
126TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.16990632
127FOXH1_21741376_ChIP-Seq_EPCs_Human1.15872895
128FUS_26573619_Chip-Seq_HEK293_Human1.15265467
129CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14174600
130GF1_26923725_Chip-Seq_HPCs_Mouse1.14126573
131CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13999412
132PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13391763
133ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12710260
134NCOR_22424771_ChIP-Seq_293T_Human1.12629900
135CTCF_27219007_Chip-Seq_Bcells_Human1.11884209
136FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11666682
137FOXA1_25329375_ChIP-Seq_VCAP_Human1.11666682
138GATA6_21074721_ChIP-Seq_CACO-2_Human1.11318213
139PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11044107
140TP63_22573176_ChIP-Seq_HFKS_Human1.11016434
141MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10952061
142SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.10893601
143ELK4_26923725_Chip-Seq_MESODERM_Mouse1.10851308
144SMRT_27268052_Chip-Seq_Bcells_Human1.09244372
145EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08959329
146P53_21459846_ChIP-Seq_SAOS-2_Human1.07802897
147SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07112931
148NFYA_21822215_ChIP-Seq_K562_Human1.06443768
149CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04633002
150Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03363285
151SOX2_22085726_ChIP-Seq_NPCs_Mouse1.03061686
152CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02544905
153GATA3_21867929_ChIP-Seq_CD8_Mouse1.01117850
154GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.01100321
155NFYB_21822215_ChIP-Seq_K562_Human1.00792407
156IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00763060
157ETV1_20927104_ChIP-Seq_GIST48_Human1.00074959
158TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99280226
159TBL1_22424771_ChIP-Seq_293T_Human0.96836134
160FLI1_21867929_ChIP-Seq_TH2_Mouse0.96473654
161FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.95710663
162TAF15_26573619_Chip-Seq_HEK293_Human0.95381864
163RUNX1_26923725_Chip-Seq_HPCs_Mouse0.94187515
164TCF4_23295773_ChIP-Seq_U87_Human0.91676439
165ZNF274_21170338_ChIP-Seq_K562_Hela0.90937567
166FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89185079
167GF1B_26923725_Chip-Seq_HPCs_Mouse0.86943677
168PHF8_20622853_ChIP-Seq_HELA_Human0.85691618
169IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.84449976
170FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83138425
171PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.82455717
172AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82098503

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.59058156
2MP0003698_abnormal_male_reproductive4.93418347
3MP0001929_abnormal_gametogenesis4.73377879
4MP0003878_abnormal_ear_physiology4.13287223
5MP0005377_hearing/vestibular/ear_phenot4.13287223
6MP0002210_abnormal_sex_determination3.51916512
7MP0003718_maternal_effect3.05870797
8MP0001145_abnormal_male_reproductive2.75399858
9MP0002161_abnormal_fertility/fecundity2.61956681
10MP0002653_abnormal_ependyma_morphology2.50974746
11MP0001348_abnormal_lacrimal_gland2.49880643
12MP0000653_abnormal_sex_gland2.44888601
13MP0008057_abnormal_DNA_replication2.43631684
14MP0001545_abnormal_hematopoietic_system2.27571174
15MP0005397_hematopoietic_system_phenotyp2.27571174
16MP0008058_abnormal_DNA_repair2.27006250
17MP0003787_abnormal_imprinting2.09616403
18MP0000678_abnormal_parathyroid_gland2.05855552
19MP0010094_abnormal_chromosome_stability2.02733823
20MP0005410_abnormal_fertilization12.0115409
21MP0002160_abnormal_reproductive_system1.92808777
22MP0009278_abnormal_bone_marrow1.86302285
23MP0002138_abnormal_hepatobiliary_system1.81070251
24MP0008995_early_reproductive_senescence1.66240580
25MP0008007_abnormal_cellular_replicative1.60824486
26MP0002282_abnormal_trachea_morphology1.57476239
27MP0001485_abnormal_pinna_reflex1.56735089
28MP0002132_abnormal_respiratory_system1.55135906
29MP0009053_abnormal_anal_canal1.50961934
30MP0005310_abnormal_salivary_gland1.47584640
31MP0001486_abnormal_startle_reflex1.40092340
32MP0003786_premature_aging1.37484706
33MP0003646_muscle_fatigue1.35877318
34MP0001986_abnormal_taste_sensitivity1.33966277
35MP0003111_abnormal_nucleus_morphology1.33601805
36MP0005670_abnormal_white_adipose1.31455094
37MP0004742_abnormal_vestibular_system1.30702560
38MP0002102_abnormal_ear_morphology1.29145369
39MP0002249_abnormal_larynx_morphology1.29062389
40MP0000569_abnormal_digit_pigmentation1.26813914
41MP0005395_other_phenotype1.26727959
42MP0001968_abnormal_touch/_nociception1.25999304
43MP0004808_abnormal_hematopoietic_stem1.24199410
44MP0005389_reproductive_system_phenotype1.21855539
45MP0005379_endocrine/exocrine_gland_phen1.21779095
46MP0003879_abnormal_hair_cell1.20744403
47MP0009785_altered_susceptibility_to1.20096028
48MP0003693_abnormal_embryo_hatching1.20028576
49MP0001853_heart_inflammation1.06859146
50MP0000015_abnormal_ear_pigmentation1.06748135
51MP0001661_extended_life_span1.05992570
52MP0001835_abnormal_antigen_presentation1.05781366
53MP0005646_abnormal_pituitary_gland1.05098256
54MP0001984_abnormal_olfaction1.04137150
55MP0001963_abnormal_hearing_physiology1.02982368
56MP0002148_abnormal_hypersensitivity_rea1.02183057
57MP0002928_abnormal_bile_duct1.01396173
58MP0002735_abnormal_chemical_nociception0.98715311
59MP0003724_increased_susceptibility_to0.98656354
60MP0001501_abnormal_sleep_pattern0.95785185
61MP0001119_abnormal_female_reproductive0.95326319
62MP0002163_abnormal_gland_morphology0.93651370
63MP0000026_abnormal_inner_ear0.93151349
64MP0005623_abnormal_meninges_morphology0.92738192
65MP0002876_abnormal_thyroid_physiology0.91510040
66MP0002822_catalepsy0.88457864
67MP0000383_abnormal_hair_follicle0.88042009
68MP0005647_abnormal_sex_gland0.86922506
69MP0002405_respiratory_system_inflammati0.86251741
70MP0002234_abnormal_pharynx_morphology0.85915480
71MP0001188_hyperpigmentation0.82732692
72MP0003763_abnormal_thymus_physiology0.82173269
73MP0000685_abnormal_immune_system0.81719526
74MP0001293_anophthalmia0.81357566
75MP0003011_delayed_dark_adaptation0.80989457
76MP0002419_abnormal_innate_immunity0.79763560
77MP0002229_neurodegeneration0.78814997
78MP0001764_abnormal_homeostasis0.78352581
79MP0002277_abnormal_respiratory_mucosa0.74916973
80MP0005451_abnormal_body_composition0.74790473
81MP0005666_abnormal_adipose_tissue0.73270710
82MP0002067_abnormal_sensory_capabilities0.72155370
83MP0009250_abnormal_appendicular_skeleto0.70594263
84MP0005025_abnormal_response_to0.69253718
85MP0003077_abnormal_cell_cycle0.69125210
86MP0002127_abnormal_cardiovascular_syste0.68930769
87MP0002723_abnormal_immune_serum0.68639048
88MP0003868_abnormal_feces_composition0.67739325
89MP0009046_muscle_twitch0.66933200
90MP0000534_abnormal_ureter_morphology0.66763473
91MP0001819_abnormal_immune_cell0.66600567
92MP0002452_abnormal_antigen_presenting0.65721069
93MP0002420_abnormal_adaptive_immunity0.65257278
94MP0009115_abnormal_fat_cell0.64955574
95MP0005409_darkened_coat_color0.64948587
96MP0005671_abnormal_response_to0.64618593
97MP0006082_CNS_inflammation0.64320148
98MP0000955_abnormal_spinal_cord0.63734065
99MP0005387_immune_system_phenotype0.63609841
100MP0001790_abnormal_immune_system0.63609841
101MP0003119_abnormal_digestive_system0.62990778
102MP0003436_decreased_susceptibility_to0.62126843
103MP0003121_genomic_imprinting0.60492847
104MP0004085_abnormal_heartbeat0.60065021
105MP0001905_abnormal_dopamine_level0.59797830
106MP0003950_abnormal_plasma_membrane0.59491438
107MP0001919_abnormal_reproductive_system0.59278013
108MP0001800_abnormal_humoral_immune0.59152885
109MP0002557_abnormal_social/conspecific_i0.57744027
110MP0000427_abnormal_hair_cycle0.57299655
111MP0006292_abnormal_olfactory_placode0.56602977
112MP0010307_abnormal_tumor_latency0.56552571
113MP0009697_abnormal_copulation0.55006047
114MP0003699_abnormal_female_reproductive0.54561548
115MP0002398_abnormal_bone_marrow0.54551759
116MP0005367_renal/urinary_system_phenotyp0.53614059
117MP0000516_abnormal_urinary_system0.53614059
118MP0003045_fibrosis0.53530200
119MP0001666_abnormal_nutrient_absorption0.53499589
120MP0005000_abnormal_immune_tolerance0.52587672
121MP0002736_abnormal_nociception_after0.52431856
122MP0005248_abnormal_Harderian_gland0.51644274
123MP0000313_abnormal_cell_death0.51402377
124MP0004134_abnormal_chest_morphology0.50898690
125MP0005645_abnormal_hypothalamus_physiol0.50034990
126MP0003943_abnormal_hepatobiliary_system0.50002688
127MP0001879_abnormal_lymphatic_vessel0.49751875
128MP0003183_abnormal_peptide_metabolism0.49159474
129MP0005365_abnormal_bile_salt0.48860413
130MP0005332_abnormal_amino_acid0.48704433
131MP0009745_abnormal_behavioral_response0.48531529
132MP0005636_abnormal_mineral_homeostasis0.48121302
133MP0005423_abnormal_somatic_nervous0.47270256
134MP0004957_abnormal_blastocyst_morpholog0.46826544
135MP0000703_abnormal_thymus_morphology0.46787429
136MP0005174_abnormal_tail_pigmentation0.46705726
137MP0000716_abnormal_immune_system0.46548040
138MP0009764_decreased_sensitivity_to0.46484060
139MP0002272_abnormal_nervous_system0.46190704
140MP0000689_abnormal_spleen_morphology0.45998596
141MP0003936_abnormal_reproductive_system0.45525814
142MP0004233_abnormal_muscle_weight0.45202684
143MP0000681_abnormal_thyroid_gland0.45183358
144MP0010678_abnormal_skin_adnexa0.44981285
145MP0000049_abnormal_middle_ear0.44866239
146MP0005253_abnormal_eye_physiology0.44805130
147MP0005503_abnormal_tendon_morphology0.43897775
148MP0003137_abnormal_impulse_conducting0.42367003
149MP0002095_abnormal_skin_pigmentation0.42066810
150MP0005391_vision/eye_phenotype0.42044743
151MP0005375_adipose_tissue_phenotype0.42027421
152MP0002572_abnormal_emotion/affect_behav0.41388129
153MP0005275_abnormal_skin_tensile0.41027877
154MP0002733_abnormal_thermal_nociception0.40344341
155MP0008961_abnormal_basal_metabolism0.40051479
156MP0001845_abnormal_inflammatory_respons0.40000998
157MP0003136_yellow_coat_color0.39778367
158MP0001765_abnormal_ion_homeostasis0.39575085
159MP0005551_abnormal_eye_electrophysiolog0.38389844

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.16685323
2Abnormal respiratory motile cilium morphology (HP:0005938)7.72946704
3Abnormal respiratory epithelium morphology (HP:0012253)7.72946704
4Rhinitis (HP:0012384)6.82623665
5Abnormal ciliary motility (HP:0012262)6.77780625
6Severe visual impairment (HP:0001141)6.72401442
7Chronic bronchitis (HP:0004469)5.89560466
8Infertility (HP:0000789)5.22451098
9Nasal polyposis (HP:0100582)4.91751646
10Attenuation of retinal blood vessels (HP:0007843)4.80063650
11Bony spicule pigmentary retinopathy (HP:0007737)4.48956963
12Abnormality of the nasal mucosa (HP:0000433)4.41384976
13Nephronophthisis (HP:0000090)4.30471058
14Bronchiectasis (HP:0002110)4.17307967
15Bronchitis (HP:0012387)3.86511972
16Asymmetric septal hypertrophy (HP:0001670)3.82864656
17Hyperkalemia (HP:0002153)3.80514407
18Abnormal rod and cone electroretinograms (HP:0008323)3.53568412
19Abnormality of the renal medulla (HP:0100957)3.50617466
20Resting tremor (HP:0002322)3.45491103
21Abnormality of macular pigmentation (HP:0008002)3.41503304
22Cone-rod dystrophy (HP:0000548)3.39600685
23Tubulointerstitial nephritis (HP:0001970)3.37721231
24Male infertility (HP:0003251)3.32544317
25Aplasia/Hypoplasia of the earlobes (HP:0009906)3.26072883
26Recurrent sinusitis (HP:0011108)3.25436575
27Abnormal spermatogenesis (HP:0008669)3.10958021
28Enlarged epiphyses (HP:0010580)3.08560025
29Occipital encephalocele (HP:0002085)3.00764551
30Facial shape deformation (HP:0011334)2.98172837
31Potter facies (HP:0002009)2.98172837
32Abnormality of midbrain morphology (HP:0002418)2.91132732
33Molar tooth sign on MRI (HP:0002419)2.91132732
34Recurrent otitis media (HP:0000403)2.87548471
35Truncal obesity (HP:0001956)2.86925620
36Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.77330640
37Abnormal urine output (HP:0012590)2.72362539
38Oligodactyly (hands) (HP:0001180)2.67909666
39Bile duct proliferation (HP:0001408)2.61878359
40Abnormal biliary tract physiology (HP:0012439)2.61878359
41Hypoplasia of the capital femoral epiphysis (HP:0003090)2.60582824
42Amelogenesis imperfecta (HP:0000705)2.59803456
43Absent frontal sinuses (HP:0002688)2.52289058
44Recurrent bronchitis (HP:0002837)2.51146309
45Postaxial foot polydactyly (HP:0001830)2.51040181
46Tubular atrophy (HP:0000092)2.46090788
47Abnormality of renal excretion (HP:0011036)2.45812322
48Polyuria (HP:0000103)2.45381283
49Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.44551984
50Absent epiphyses (HP:0010577)2.44551984
51Tubulointerstitial abnormality (HP:0001969)2.43051153
52Hypoplasia of the thymus (HP:0000778)2.40840844
53Impulsivity (HP:0100710)2.39105800
54Azoospermia (HP:0000027)2.38514827
55Fibular hypoplasia (HP:0003038)2.37705967
56Medial flaring of the eyebrow (HP:0010747)2.36584457
57Progressive cerebellar ataxia (HP:0002073)2.35528716
58Hypoplastic ischia (HP:0003175)2.29625025
59Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28324661
60Volvulus (HP:0002580)2.28199709
61Menstrual irregularities (HP:0000858)2.26966312
62Unilateral renal agenesis (HP:0000122)2.26961205
63Horizontal nystagmus (HP:0000666)2.26389407
64Abnormality of dental color (HP:0011073)2.26145792
65Abnormality of the costochondral junction (HP:0000919)2.25131798
66Generalized aminoaciduria (HP:0002909)2.22953713
67True hermaphroditism (HP:0010459)2.21475742
68Postural instability (HP:0002172)2.20699743
69Abnormality of potassium homeostasis (HP:0011042)2.20585121
70Portal hypertension (HP:0001409)2.19523190
71Neonatal hypoglycemia (HP:0001998)2.18918401
72Abnormality of the renal cortex (HP:0011035)2.18792486
73Congenital hepatic fibrosis (HP:0002612)2.16851401
74Median cleft lip (HP:0000161)2.16288437
75Pancreatic fibrosis (HP:0100732)2.15236392
76Intellectual disability, moderate (HP:0002342)2.14991827
77Abnormality of the hepatic vasculature (HP:0006707)2.14363715
78Gonadotropin excess (HP:0000837)2.12536111
79Osteomalacia (HP:0002749)2.11642828
80Chromsome breakage (HP:0040012)2.11225953
81Scotoma (HP:0000575)2.08295909
82Abnormality of the ischium (HP:0003174)2.08040746
83Congenital stationary night blindness (HP:0007642)2.05274405
84Renal dysplasia (HP:0000110)2.04659942
85Hypoalphalipoproteinemia (HP:0003233)2.01358060
86Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.8277261
87Dynein arm defect of respiratory motile cilia (HP:0012255)10.6071919
88Absent/shortened dynein arms (HP:0200106)10.6071919
89Spontaneous abortion (HP:0005268)1.99118760
90Ectopic kidney (HP:0000086)1.94516540
91Abnormality of permanent molar morphology (HP:0011071)1.92822884
92Abnormality of the dental root (HP:0006486)1.92822884
93Taurodontia (HP:0000679)1.92822884
94Microglossia (HP:0000171)1.91297120
95Widely patent fontanelles and sutures (HP:0004492)1.90507628
96Progressive sensorineural hearing impairment (HP:0000408)1.90298413
97Abnormal drinking behavior (HP:0030082)1.88751548
98Polydipsia (HP:0001959)1.88751548
99Stage 5 chronic kidney disease (HP:0003774)1.87052210
100Abnormality of molar morphology (HP:0011070)1.86494576
101Abnormality of molar (HP:0011077)1.86494576
102Pancreatic cysts (HP:0001737)1.86018942
103Impaired proprioception (HP:0010831)1.85416924
104Short femoral neck (HP:0100864)1.83838896
105Cystic liver disease (HP:0006706)1.82989872
106Short ribs (HP:0000773)1.82330304
107Short thorax (HP:0010306)1.82255075
108Aplasia/Hypoplasia of the tongue (HP:0010295)1.82164985
109Congenital, generalized hypertrichosis (HP:0004540)1.81928135
110Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.81037604
111Abnormality of chloride homeostasis (HP:0011422)1.80057937
112Type II lissencephaly (HP:0007260)1.77918967
113Photophobia (HP:0000613)1.77507977
114Insulin-resistant diabetes mellitus (HP:0000831)1.77095059
115Pili torti (HP:0003777)1.76451729
116Oligodactyly (HP:0012165)1.75008583
117Chronic hepatic failure (HP:0100626)1.74294398
118Irregular epiphyses (HP:0010582)1.72728779
119Congenital sensorineural hearing impairment (HP:0008527)1.71572860
120Aplasia/Hypoplasia of the uvula (HP:0010293)1.69587400
121Abnormality of the dental pulp (HP:0006479)1.68685660
122Facial cleft (HP:0002006)1.68551548
123Optic nerve hypoplasia (HP:0000609)1.68482764
124Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.65360103
125Supernumerary spleens (HP:0009799)1.65233879
126Postaxial hand polydactyly (HP:0001162)1.64917929
127Chronic sinusitis (HP:0011109)1.63559015
128Hyponatremia (HP:0002902)1.61430890
129Sclerocornea (HP:0000647)1.60465691
130Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.60240082
131Genital tract atresia (HP:0001827)1.59980086
132Duodenal stenosis (HP:0100867)1.58535139
133Small intestinal stenosis (HP:0012848)1.58535139
134Pendular nystagmus (HP:0012043)1.58531917
135Nephropathy (HP:0000112)1.57554374
136Bell-shaped thorax (HP:0001591)1.56879177
137Tubulointerstitial fibrosis (HP:0005576)1.56301636
138Decreased central vision (HP:0007663)1.56128672
139Abnormality of the epiphysis of the femoral head (HP:0010574)1.55542360
140J-shaped sella turcica (HP:0002680)1.55018980
141Flattened epiphyses (HP:0003071)1.53455813
142Retrobulbar optic neuritis (HP:0100654)1.52944981
143Optic neuritis (HP:0100653)1.52944981
144Preaxial hand polydactyly (HP:0001177)1.51923706
145Meckel diverticulum (HP:0002245)1.51207564
146Abnormality of femoral epiphyses (HP:0006499)1.50747571
147Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.50747571
148Aplasia/Hypoplasia of the fibula (HP:0006492)1.50418600
149Abnormality of the preputium (HP:0100587)1.50119939
150Oculomotor apraxia (HP:0000657)1.48555597
151Glucose intolerance (HP:0000833)1.48073933
152Abnormality of the ileum (HP:0001549)1.47550187
153Myositis (HP:0100614)1.46781188
154Abnormality of chromosome stability (HP:0003220)1.44574698
155Abnormality of the frontal sinuses (HP:0002687)1.44492574
156Abnormality of the femoral head (HP:0003368)1.42468666
157Dyschromatopsia (HP:0007641)1.42232999
158Abnormal gallbladder physiology (HP:0012438)1.41516038
159Cholecystitis (HP:0001082)1.41516038
160Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.37811416

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.92100845
2PDK47.92100845
3PDK25.40425730
4TESK13.49407639
5DDR23.34683190
6MAP4K23.21760642
7PLK23.18781575
8PRKD32.87285320
9CAMK1G2.82181734
10STK162.25666622
11NME22.11903083
12ICK2.09092804
13PTK2B2.03549734
14NEK21.88866690
15PIK3CG1.85726431
16CCNB11.81054804
17MET1.64071753
18PNCK1.49456478
19MST1R1.48846262
20PDPK11.42072211
21MAPK151.29924511
22ACVR1B1.28580545
23WNK41.27623782
24TXK1.26938233
25CDC71.26603572
26CDK191.21934077
27WEE11.17615368
28STK31.14146493
29OXSR11.10285158
30STK38L1.06957512
31TEC1.06348977
32DYRK31.06063312
33STK391.05180294
34ZAK0.96970985
35NEK60.95991331
36ATR0.94492716
37STK380.94026075
38CDK30.91773061
39PLK40.91716480
40MAP3K140.91413957
41IRAK40.90925764
42TAOK20.87465055
43RIPK40.86912294
44EIF2AK20.86640706
45YES10.86562701
46CASK0.82181448
47MAPK130.79973477
48MAP2K70.77177386
49CDK90.76922117
50PRPF4B0.74050910
51BRAF0.73140434
52CHEK20.72316325
53MAP2K20.72166293
54MAP2K60.72073500
55BMPR1B0.71676359
56TTK0.69690859
57PDK10.68880908
58TYRO30.68266918
59MKNK20.66468430
60IRAK10.66264694
61DYRK1B0.63485514
62CDK80.61573578
63PRKG10.58902327
64CSK0.58822859
65MAP3K90.57772713
66PRKAA20.56935018
67CHEK10.56768401
68WNK10.56356439
69PRKG20.56218630
70CAMK1D0.53640166
71RPS6KA10.53331262
72GRK10.53228619
73BCR0.52783262
74CAMK10.52744416
75PLK10.52717012
76ATM0.51862447
77PINK10.49908865
78BMPR20.49603835
79SIK30.48254994
80PASK0.47998122
81STK240.47794391
82ERBB30.46414827
83CDK10.46303523
84BRD40.46278052
85ADRBK20.45929470
86NTRK30.43641497
87INSRR0.42639919
88MUSK0.42629447
89SGK10.42622786
90NUAK10.42005312
91AURKA0.40847613
92ROCK10.40327893
93FRK0.39822600
94TBK10.38953602
95GSK3B0.38866460
96RPS6KB10.37655563
97MAP3K40.36973813
98MAPK10.35245431
99CDK120.34332030
100NLK0.34093398
101LATS20.33693912
102BTK0.33304210
103CLK10.33143965
104AKT30.33086995
105KSR20.32173302
106TNIK0.31284949
107PIM10.31026718
108MAPK70.30672722
109SRPK10.29982905
110RPS6KA20.29386072
111MAP3K80.28466490
112LATS10.28284145
113PRKAA10.27697967
114TAF10.27532601
115PRKACB0.27465474
116CDK70.26281317
117DAPK20.26197657
118MAPK110.25257451
119ARAF0.24507427
120CHUK0.24376007
121TIE10.24368566
122IKBKB0.24094801
123BRSK20.23846997
124SGK20.22960920
125BRSK10.22450001
126CDK40.22367083
127PIM20.21856640
128MAPK140.21519789
129STK100.21184967
130ZAP700.20687251
131MAPK80.20662420
132ITK0.20038686
133CSF1R0.19970170
134PRKCQ0.19481008
135PBK0.19333105
136MKNK10.19056681
137BMX0.18666384
138CSNK2A10.18551456
139EPHA20.18519751
140MAP3K20.18462289
141GRK70.18071042
142VRK10.17712811
143RPS6KA60.16994323
144SGK4940.16704783
145SGK2230.16704783
146PRKCG0.15757460
147PKN10.15666925
148MTOR0.15622067
149KIT0.15077439
150CAMK40.14717045
151RPS6KA40.14603937
152MAPK100.14245060
153CDK20.14077285
154TESK20.13759782
155MAP3K50.13086937
156BUB10.12700304

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.43979414
2Vitamin B6 metabolism_Homo sapiens_hsa007503.73541851
3Fanconi anemia pathway_Homo sapiens_hsa034603.68479685
4Basal transcription factors_Homo sapiens_hsa030223.31042583
5Butanoate metabolism_Homo sapiens_hsa006502.67840592
6Fatty acid degradation_Homo sapiens_hsa000712.48212509
7Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.38478741
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29225603
9Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.28928028
10Non-homologous end-joining_Homo sapiens_hsa034502.04164808
11Linoleic acid metabolism_Homo sapiens_hsa005911.87724923
12Fatty acid biosynthesis_Homo sapiens_hsa000611.85462728
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.84934937
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.83303213
15Fatty acid metabolism_Homo sapiens_hsa012121.83284215
16Pyruvate metabolism_Homo sapiens_hsa006201.80422351
17beta-Alanine metabolism_Homo sapiens_hsa004101.71305564
18Nitrogen metabolism_Homo sapiens_hsa009101.71002405
19RNA transport_Homo sapiens_hsa030131.68814012
20Selenocompound metabolism_Homo sapiens_hsa004501.68282362
21Glucagon signaling pathway_Homo sapiens_hsa049221.65467612
22Homologous recombination_Homo sapiens_hsa034401.63843315
23mRNA surveillance pathway_Homo sapiens_hsa030151.60181903
24Pentose phosphate pathway_Homo sapiens_hsa000301.57967822
25Purine metabolism_Homo sapiens_hsa002301.55596881
26Cell cycle_Homo sapiens_hsa041101.54335751
27Dorso-ventral axis formation_Homo sapiens_hsa043201.53476877
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44519574
29Allograft rejection_Homo sapiens_hsa053301.43851484
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.41736999
31Antigen processing and presentation_Homo sapiens_hsa046121.37908823
32Legionellosis_Homo sapiens_hsa051341.35760090
33Measles_Homo sapiens_hsa051621.34454451
34Phenylalanine metabolism_Homo sapiens_hsa003601.34267632
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.32282878
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.31946366
37Arachidonic acid metabolism_Homo sapiens_hsa005901.31911071
38Fructose and mannose metabolism_Homo sapiens_hsa000511.31749455
39Hedgehog signaling pathway_Homo sapiens_hsa043401.31003581
40Arginine and proline metabolism_Homo sapiens_hsa003301.29641150
41Pyrimidine metabolism_Homo sapiens_hsa002401.28968795
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.25363315
43Glycerolipid metabolism_Homo sapiens_hsa005611.25190778
44Graft-versus-host disease_Homo sapiens_hsa053321.22330602
45Phototransduction_Homo sapiens_hsa047441.21800795
46Propanoate metabolism_Homo sapiens_hsa006401.21676299
47Herpes simplex infection_Homo sapiens_hsa051681.21170225
48RNA degradation_Homo sapiens_hsa030181.20980086
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20611384
50PPAR signaling pathway_Homo sapiens_hsa033201.19165871
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.18215535
52Type II diabetes mellitus_Homo sapiens_hsa049301.18169283
53p53 signaling pathway_Homo sapiens_hsa041151.17696691
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16732301
55NF-kappa B signaling pathway_Homo sapiens_hsa040641.16439984
56Influenza A_Homo sapiens_hsa051641.16286779
57Autoimmune thyroid disease_Homo sapiens_hsa053201.14691553
58Primary immunodeficiency_Homo sapiens_hsa053401.13544032
59Intestinal immune network for IgA production_Homo sapiens_hsa046721.11489025
60Sphingolipid metabolism_Homo sapiens_hsa006001.01837937
61Oocyte meiosis_Homo sapiens_hsa041141.00716825
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.95803621
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94734703
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94060413
65Base excision repair_Homo sapiens_hsa034100.92651342
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92342606
67Rheumatoid arthritis_Homo sapiens_hsa053230.89796337
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89381077
69Hematopoietic cell lineage_Homo sapiens_hsa046400.89202523
70Huntingtons disease_Homo sapiens_hsa050160.88973745
71Arginine biosynthesis_Homo sapiens_hsa002200.85579251
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.85278543
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84102613
74Epstein-Barr virus infection_Homo sapiens_hsa051690.83155222
75Tryptophan metabolism_Homo sapiens_hsa003800.82341443
76Lysine degradation_Homo sapiens_hsa003100.81632176
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81236589
78Ether lipid metabolism_Homo sapiens_hsa005650.80845381
79Histidine metabolism_Homo sapiens_hsa003400.79481711
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77944856
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.77285363
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74812742
83Peroxisome_Homo sapiens_hsa041460.74760392
84Fat digestion and absorption_Homo sapiens_hsa049750.74617534
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73889764
86Circadian rhythm_Homo sapiens_hsa047100.73320801
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72111724
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.71726315
89DNA replication_Homo sapiens_hsa030300.71401421
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69609809
91Renin-angiotensin system_Homo sapiens_hsa046140.68861108
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68680729
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67315985
94Salivary secretion_Homo sapiens_hsa049700.67183044
95Leishmaniasis_Homo sapiens_hsa051400.65011502
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63357945
97Circadian entrainment_Homo sapiens_hsa047130.62089827
98Endocytosis_Homo sapiens_hsa041440.61201485
99Type I diabetes mellitus_Homo sapiens_hsa049400.60721990
100Spliceosome_Homo sapiens_hsa030400.60324614
101cAMP signaling pathway_Homo sapiens_hsa040240.59352395
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58857691
103Tyrosine metabolism_Homo sapiens_hsa003500.58784576
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58531809
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.58074346
106TNF signaling pathway_Homo sapiens_hsa046680.57056133
107Mismatch repair_Homo sapiens_hsa034300.56914636
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56658163
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55763153
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55236709
111Asthma_Homo sapiens_hsa053100.53448291
112Vitamin digestion and absorption_Homo sapiens_hsa049770.53211599
113Bile secretion_Homo sapiens_hsa049760.53204708
114Chemical carcinogenesis_Homo sapiens_hsa052040.52940871
115Mineral absorption_Homo sapiens_hsa049780.52859035
116Nicotine addiction_Homo sapiens_hsa050330.52788165
117Staphylococcus aureus infection_Homo sapiens_hsa051500.52402044
118Malaria_Homo sapiens_hsa051440.52073692
119RNA polymerase_Homo sapiens_hsa030200.51552063
120Toxoplasmosis_Homo sapiens_hsa051450.51004484
121Osteoclast differentiation_Homo sapiens_hsa043800.50086243
122T cell receptor signaling pathway_Homo sapiens_hsa046600.48809608
123Nucleotide excision repair_Homo sapiens_hsa034200.48551523
124Retinol metabolism_Homo sapiens_hsa008300.48254499
125Phagosome_Homo sapiens_hsa041450.48181815
126Cardiac muscle contraction_Homo sapiens_hsa042600.47214546
127Morphine addiction_Homo sapiens_hsa050320.46548729
128Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46128988
129Calcium signaling pathway_Homo sapiens_hsa040200.45753201
130Inositol phosphate metabolism_Homo sapiens_hsa005620.45649122
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45456484
132Salmonella infection_Homo sapiens_hsa051320.45251525
133Metabolic pathways_Homo sapiens_hsa011000.44520901
134Regulation of autophagy_Homo sapiens_hsa041400.44084208
135Collecting duct acid secretion_Homo sapiens_hsa049660.43748201
136Sulfur relay system_Homo sapiens_hsa041220.42535208
137B cell receptor signaling pathway_Homo sapiens_hsa046620.42520743
138Protein digestion and absorption_Homo sapiens_hsa049740.42374979
139ABC transporters_Homo sapiens_hsa020100.41815475
140N-Glycan biosynthesis_Homo sapiens_hsa005100.41458258
141Amphetamine addiction_Homo sapiens_hsa050310.41280188
142HTLV-I infection_Homo sapiens_hsa051660.40161658
143Taste transduction_Homo sapiens_hsa047420.39392086
144Other glycan degradation_Homo sapiens_hsa005110.38529693
145Synaptic vesicle cycle_Homo sapiens_hsa047210.38309132
146Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38252515
147Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37558773
148Olfactory transduction_Homo sapiens_hsa047400.37542280
149Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37376693
150Serotonergic synapse_Homo sapiens_hsa047260.35443296
151Glutamatergic synapse_Homo sapiens_hsa047240.29807859
152One carbon pool by folate_Homo sapiens_hsa006700.29094821
153Gastric acid secretion_Homo sapiens_hsa049710.28723059
154Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27938186

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