AVPI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)7.03644414
2viral transcription (GO:0019083)6.68369892
3ribosomal small subunit biogenesis (GO:0042274)6.64372266
4translational termination (GO:0006415)6.48196344
5desmosome organization (GO:0002934)6.41656103
6ribosomal small subunit assembly (GO:0000028)6.24503021
7translational elongation (GO:0006414)5.60070930
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.27429516
9interferon-gamma secretion (GO:0072643)5.25225867
10ribosomal large subunit biogenesis (GO:0042273)5.22706457
11translational initiation (GO:0006413)5.14738290
12protein targeting to ER (GO:0045047)5.14056168
13cotranslational protein targeting to membrane (GO:0006613)5.12649465
14cellular protein complex disassembly (GO:0043624)5.08870818
15viral life cycle (GO:0019058)5.07463726
16melanin biosynthetic process (GO:0042438)5.06750282
17protein localization to endoplasmic reticulum (GO:0070972)4.87337464
18hemidesmosome assembly (GO:0031581)4.86595510
19proteasome assembly (GO:0043248)4.83609546
20establishment of protein localization to endoplasmic reticulum (GO:0072599)4.83403816
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.72532617
22DNA deamination (GO:0045006)4.42333987
23establishment of skin barrier (GO:0061436)4.41670687
24regulation of water loss via skin (GO:0033561)4.31073443
25melanin metabolic process (GO:0006582)4.28286585
26protein complex disassembly (GO:0043241)4.22691063
27formation of translation preinitiation complex (GO:0001731)4.19748827
28ribonucleoprotein complex biogenesis (GO:0022613)4.18858467
29COPI coating of Golgi vesicle (GO:0048205)4.12734704
30Golgi transport vesicle coating (GO:0048200)4.12734704
31low-density lipoprotein particle clearance (GO:0034383)4.07126226
32macromolecular complex disassembly (GO:0032984)3.97500388
33translation (GO:0006412)3.87880896
34secondary metabolite biosynthetic process (GO:0044550)3.82634020
35keratinocyte development (GO:0003334)3.77617202
36regulation of cellular amino acid metabolic process (GO:0006521)3.53627878
37skin morphogenesis (GO:0043589)3.51662643
38protein targeting to membrane (GO:0006612)3.48930441
39ribosome assembly (GO:0042255)3.45661563
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.45139027
41regulation of early endosome to late endosome transport (GO:2000641)3.41144959
42urea cycle (GO:0000050)3.39431982
43purine nucleobase biosynthetic process (GO:0009113)3.36808003
44positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.35643802
45folic acid metabolic process (GO:0046655)3.34183693
46DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.33205516
47cell-substrate junction assembly (GO:0007044)3.30892977
48signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.29110111
49signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.29110111
50signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.29110111
51signal transduction involved in DNA integrity checkpoint (GO:0072401)3.28492991
52signal transduction involved in DNA damage checkpoint (GO:0072422)3.28492991
53protein hydroxylation (GO:0018126)3.27652663
54peptidyl-proline hydroxylation (GO:0019511)3.26348058
55intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.26214871
56signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.26214871
57nuclear-transcribed mRNA catabolic process (GO:0000956)3.25961781
58negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.25570044
59signal transduction involved in cell cycle checkpoint (GO:0072395)3.21095244
60keratinization (GO:0031424)3.18730474
61regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.17552153
62anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.16444794
63cellular component biogenesis (GO:0044085)3.15187603
64protein maturation by protein folding (GO:0022417)3.11372991
65nucleobase-containing small molecule interconversion (GO:0015949)3.09264039
66rRNA processing (GO:0006364)3.08018599
67mRNA catabolic process (GO:0006402)3.07744057
68negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.07671298
69negative regulation of ligase activity (GO:0051352)3.07671298
70establishment of protein localization to mitochondrial membrane (GO:0090151)3.06839155
71urea metabolic process (GO:0019627)3.04163526
72positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.04110242
73regulation of gene silencing by RNA (GO:0060966)3.02483459
74regulation of posttranscriptional gene silencing (GO:0060147)3.02483459
75regulation of gene silencing by miRNA (GO:0060964)3.02483459
76nucleobase biosynthetic process (GO:0046112)3.02248518
77maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.00699024
78protein retention in ER lumen (GO:0006621)2.99693723
79antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.99657262
80ribosome biogenesis (GO:0042254)2.99422664
81epithelial cell-cell adhesion (GO:0090136)2.99328840
82folic acid transport (GO:0015884)2.98933813
83homocysteine metabolic process (GO:0050667)2.98658623
84L-methionine salvage (GO:0071267)2.95083594
85L-methionine biosynthetic process (GO:0071265)2.95083594
86amino acid salvage (GO:0043102)2.95083594
87rRNA metabolic process (GO:0016072)2.93909660
88hair cycle (GO:0042633)2.93427672
89molting cycle (GO:0042303)2.93427672
90regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.92235660
91adhesion of symbiont to host (GO:0044406)2.90836086
92rRNA modification (GO:0000154)2.90356234
93regulation of chemokine secretion (GO:0090196)2.89230481
94positive regulation of ligase activity (GO:0051351)2.88462448
95progesterone metabolic process (GO:0042448)2.88259557
96regulation of cholesterol homeostasis (GO:2000188)2.87824900
97L-serine transport (GO:0015825)2.83895210
98intestinal epithelial cell development (GO:0060576)2.83065632
99multicellular organismal water homeostasis (GO:0050891)2.83062413
100protein localization to endosome (GO:0036010)2.81510499
101RNA catabolic process (GO:0006401)2.81273738
102antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.80776165
103transcription elongation from RNA polymerase III promoter (GO:0006385)2.80588290
104termination of RNA polymerase III transcription (GO:0006386)2.80588290
105regulation of integrin-mediated signaling pathway (GO:2001044)2.79991178
106cellular copper ion homeostasis (GO:0006878)2.79890887
107GDP-mannose metabolic process (GO:0019673)2.79665936
108midgut development (GO:0007494)2.78334040
109nitrogen cycle metabolic process (GO:0071941)2.77794621
110barbed-end actin filament capping (GO:0051016)2.77782386
111cellular protein complex localization (GO:0034629)2.76736328
112primary alcohol catabolic process (GO:0034310)2.75902209
113glycine metabolic process (GO:0006544)2.75891035
114L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.75054561
115diaphragm development (GO:0060539)2.73628865
116positive regulation of cell cycle arrest (GO:0071158)2.71976221
117lung-associated mesenchyme development (GO:0060484)2.71483650
118regulation of cell proliferation involved in kidney development (GO:1901722)2.69265484
119cell adhesion mediated by integrin (GO:0033627)2.68896815
120prostanoid biosynthetic process (GO:0046457)2.68444333
121prostaglandin biosynthetic process (GO:0001516)2.68444333
122water homeostasis (GO:0030104)2.68245236
123pinocytosis (GO:0006907)2.67870441
124keratinocyte proliferation (GO:0043616)2.67604778
125mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.67283044
126negative regulation of keratinocyte proliferation (GO:0010839)2.63918080
127cellular response to arsenic-containing substance (GO:0071243)2.63498994
128hyaluronan catabolic process (GO:0030214)2.63435960
129amyloid precursor protein catabolic process (GO:0042987)2.63042622
130regulation of gonadotropin secretion (GO:0032276)2.62487409
131deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.61583634
132proline biosynthetic process (GO:0006561)2.61483573
133retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.61462817
134cellular response to cadmium ion (GO:0071276)2.59122823
135regulation of cellular amine metabolic process (GO:0033238)2.59117544
136galactose metabolic process (GO:0006012)2.57176832
137pentose-phosphate shunt (GO:0006098)2.56911074
138establishment of protein localization to membrane (GO:0090150)2.56577817
139regulation of cholesterol biosynthetic process (GO:0045540)2.56286841
140galactose catabolic process (GO:0019388)2.55733110
141positive regulation of epidermis development (GO:0045684)2.55044599
142pseudouridine synthesis (GO:0001522)2.54552985
143keratinocyte differentiation (GO:0030216)2.54165128
144regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.54152304
145basement membrane organization (GO:0071711)2.53199861
146oxidative phosphorylation (GO:0006119)2.53079198
147bundle of His cell to Purkinje myocyte communication (GO:0086069)2.52063196
148focal adhesion assembly (GO:0048041)2.51681195
149cell-substrate adherens junction assembly (GO:0007045)2.51681195
150serine transport (GO:0032329)2.51615298
151NADH metabolic process (GO:0006734)2.51311434
152cyclooxygenase pathway (GO:0019371)2.51264912
153regulation of cholesterol storage (GO:0010885)2.49223658
154transcription from RNA polymerase I promoter (GO:0006360)2.49104586
155regulation of metalloenzyme activity (GO:0048552)2.48755622
1564-hydroxyproline metabolic process (GO:0019471)2.48326587
157mitotic metaphase plate congression (GO:0007080)2.47392687
158regulation of ubiquitin-protein transferase activity (GO:0051438)2.46643496
159positive regulation of hair cycle (GO:0042635)2.45172548
160positive regulation of hair follicle development (GO:0051798)2.45172548
161monosaccharide biosynthetic process (GO:0046364)2.43608235
162glucose catabolic process (GO:0006007)2.43079255
163apoptotic cell clearance (GO:0043277)2.42887917
164NADPH regeneration (GO:0006740)2.42539564
165nuclear envelope reassembly (GO:0031468)2.39396585
166mitotic nuclear envelope reassembly (GO:0007084)2.39396585
167positive regulation of keratinocyte differentiation (GO:0045618)2.38987849
168negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.36769128
169atrioventricular valve morphogenesis (GO:0003181)2.35812261
170cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.35729517
171gluconeogenesis (GO:0006094)2.35015963
172daunorubicin metabolic process (GO:0044597)2.34350184
173polyketide metabolic process (GO:0030638)2.34350184
174doxorubicin metabolic process (GO:0044598)2.34350184
175decidualization (GO:0046697)2.34333796
176negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.34256771
177regulation of translational termination (GO:0006449)2.34151467
178dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.34091910
179glycosphingolipid catabolic process (GO:0046479)2.33685386
180lipopolysaccharide biosynthetic process (GO:0009103)2.32533801
181stress fiber assembly (GO:0043149)2.31009721
182gap junction assembly (GO:0016264)2.30676184
183regulation of apoptotic process involved in morphogenesis (GO:1902337)2.29461688
184adherens junction assembly (GO:0034333)2.28432484
185hexose biosynthetic process (GO:0019319)2.27468201
186androgen biosynthetic process (GO:0006702)2.26847551
187protein complex localization (GO:0031503)2.26676237
188C21-steroid hormone biosynthetic process (GO:0006700)2.24705209
189tRNA methylation (GO:0030488)2.23796355
190ventricular cardiac muscle cell development (GO:0055015)2.23722727

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.47060596
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.15408277
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.44816424
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.80448506
5ZNF263_19887448_ChIP-Seq_K562_Human2.78620334
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.73612967
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.59283562
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.49327837
9POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.45674984
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35080876
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.31502551
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.24610882
13STAT3_1855785_ChIP-Seq_MESCs_Mouse2.23868157
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.23446549
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.23108820
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.20454880
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.20150557
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.18809814
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.14314143
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11515131
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.10800699
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.10800699
23KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.10800699
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.05190887
25NANOG_18555785_ChIP-Seq_MESCs_Mouse2.02907297
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.02371837
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96837772
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.93477988
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.91106662
30XRN2_22483619_ChIP-Seq_HELA_Human1.90464714
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.89304186
32* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.86008528
33KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.84161614
34* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.80930264
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.80813785
36LXR_22292898_ChIP-Seq_THP-1_Human1.80246677
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79418283
38* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.77193587
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.76197867
40SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.74900298
41CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.73689971
42DCP1A_22483619_ChIP-Seq_HELA_Human1.71678484
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.69511932
44* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.69294228
45ELK1_22589737_ChIP-Seq_MCF10A_Human1.66701869
46E2F7_22180533_ChIP-Seq_HELA_Human1.66576302
47* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.64787380
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.61606579
49* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.61106711
50* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57585820
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54615427
52* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.52775199
53HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.51617585
54* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.50944230
55* UBF1/2_26484160_Chip-Seq_HMECs_Human1.48432117
56SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.47700531
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47371333
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46765334
59* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.46185539
60HIF1A_21447827_ChIP-Seq_MCF-7_Human1.45457741
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.45051582
62* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44121016
63PPARA_22158963_ChIP-Seq_LIVER_Mouse1.40987757
64VDR_23849224_ChIP-Seq_CD4+_Human1.40750488
65* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.40335766
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.39844995
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.39320285
68* TTF2_22483619_ChIP-Seq_HELA_Human1.38456787
69OCT4_18692474_ChIP-Seq_MEFs_Mouse1.36910375
70* ATF3_27146783_Chip-Seq_COLON_Human1.34609709
71* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33630119
72EGR1_19374776_ChIP-ChIP_THP-1_Human1.33502922
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.33389419
74TFEB_21752829_ChIP-Seq_HELA_Human1.32532853
75FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.32012286
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31466735
77* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29188305
78TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28658942
79* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.28436951
80AR_21909140_ChIP-Seq_LNCAP_Human1.28429763
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27669052
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27059468
83SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.26485705
84RXR_22158963_ChIP-Seq_LIVER_Mouse1.26412949
85TP53_22127205_ChIP-Seq_IMR90_Human1.25267052
86ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25191636
87* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25065473
88* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25065473
89SRF_21415370_ChIP-Seq_HL-1_Mouse1.24500395
90* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.23934856
91ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23504570
92TRIM28_21343339_ChIP-Seq_HEK293_Human1.23462368
93PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23389483
94KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21956713
95TET1_21451524_ChIP-Seq_MESCs_Mouse1.21644737
96CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19097117
97* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17807300
98* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16828976
99* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.15001129
100CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14093930
101HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13293142
102E2F4_17652178_ChIP-ChIP_JURKAT_Human1.12336952
103CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12105302
104* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09298201
105SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08393945
106STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08144028
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07658936
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07185083
109ELK1_19687146_ChIP-ChIP_HELA_Human1.05904897
110CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05473973
111GATA6_25053715_ChIP-Seq_YYC3_Human1.04716156
112* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.04015853
113THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03870154
114FOXM1_23109430_ChIP-Seq_U2OS_Human1.03717673
115* SMC4_20622854_ChIP-Seq_HELA_Human1.02862955
116ESR2_21235772_ChIP-Seq_MCF-7_Human1.01342562
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99984071
118JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99661358
119ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99507349
120NOTCH1_21737748_ChIP-Seq_TLL_Human0.98153063
121YY1_21170310_ChIP-Seq_MESCs_Mouse0.97404164
122* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97277136
123* P68_20966046_ChIP-Seq_HELA_Human0.97198320
124CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96002515
125* SA1_27219007_Chip-Seq_ERYTHROID_Human0.95990625
126NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.95576475
127GABP_19822575_ChIP-Seq_HepG2_Human0.95484381
128SOX2_20726797_ChIP-Seq_SW620_Human0.94614033
129TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93539929
130EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93058361
131SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92625923
132ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91609272
133RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88413037
134PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87708014
135NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.87401752
136SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.86843367
137SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.86711824
138* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86115182
139ELF1_17652178_ChIP-ChIP_JURKAT_Human0.84282949
140FOXP3_21729870_ChIP-Seq_TREG_Human0.83621816
141CLOCK_20551151_ChIP-Seq_293T_Human0.82823384
142* RACK7_27058665_Chip-Seq_MCF-7_Human0.82227429
143* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.80810541
144MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.79433802

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier4.86923483
2MP0003941_abnormal_skin_development3.96735318
3MP0002254_reproductive_system_inflammat3.76639840
4MP0003693_abnormal_embryo_hatching3.57752530
5MP0009379_abnormal_foot_pigmentation3.10979849
6MP0005501_abnormal_skin_physiology3.05311875
7MP0003806_abnormal_nucleotide_metabolis2.96039796
8MP0010352_gastrointestinal_tract_polyps2.93882311
9MP0008438_abnormal_cutaneous_collagen2.80801216
10MP0004381_abnormal_hair_follicle2.78051499
11MP0010234_abnormal_vibrissa_follicle2.74985786
12MP0003950_abnormal_plasma_membrane2.70905979
13MP0005257_abnormal_intraocular_pressure2.65082774
14MP0004957_abnormal_blastocyst_morpholog2.51174108
15MP0000372_irregular_coat_pigmentation2.48953541
16MP0003453_abnormal_keratinocyte_physiol2.44005673
17MP0002060_abnormal_skin_morphology2.32279907
18MP0001216_abnormal_epidermal_layer2.25607217
19MP0005058_abnormal_lysosome_morphology2.25496421
20MP0003718_maternal_effect2.23734392
21MP0003786_premature_aging2.14160380
22MP0005171_absent_coat_pigmentation2.11576184
23MP0005670_abnormal_white_adipose2.09304232
24MP0005275_abnormal_skin_tensile2.07662080
25MP0001346_abnormal_lacrimal_gland2.04543934
26MP0003186_abnormal_redox_activity2.04126902
27MP0004233_abnormal_muscle_weight2.01789594
28MP0003136_yellow_coat_color1.98860915
29MP0004272_abnormal_basement_membrane1.96803040
30MP0003566_abnormal_cell_adhesion1.95915465
31MP0003705_abnormal_hypodermis_morpholog1.85343816
32MP0000003_abnormal_adipose_tissue1.81771031
33MP0005623_abnormal_meninges_morphology1.81564182
34MP0000467_abnormal_esophagus_morphology1.81278708
35MP0000383_abnormal_hair_follicle1.81236414
36MP0005085_abnormal_gallbladder_physiolo1.81082323
37MP0010771_integument_phenotype1.74742882
38MP0001661_extended_life_span1.74692240
39MP0004782_abnormal_surfactant_physiolog1.68760108
40MP0002098_abnormal_vibrissa_morphology1.67666890
41MP0000762_abnormal_tongue_morphology1.66152324
42MP0000013_abnormal_adipose_tissue1.66104832
43MP0001853_heart_inflammation1.62983568
44MP0000015_abnormal_ear_pigmentation1.62842543
45MP0005023_abnormal_wound_healing1.62796427
46MP0002877_abnormal_melanocyte_morpholog1.59347565
47MP0001542_abnormal_bone_strength1.56828066
48MP0004019_abnormal_vitamin_homeostasis1.52484745
49MP0003111_abnormal_nucleus_morphology1.52335602
50MP0010678_abnormal_skin_adnexa1.48913135
51MP0008875_abnormal_xenobiotic_pharmacok1.47474481
52MP0009840_abnormal_foam_cell1.41613587
53MP0000647_abnormal_sebaceous_gland1.41530456
54MP0008007_abnormal_cellular_replicative1.40119263
55MP0000579_abnormal_nail_morphology1.39404724
56MP0002132_abnormal_respiratory_system1.38295812
57MP0000377_abnormal_hair_follicle1.38101678
58MP0005409_darkened_coat_color1.36237007
59MP0010030_abnormal_orbit_morphology1.31935146
60MP0002163_abnormal_gland_morphology1.30386072
61MP0005075_abnormal_melanosome_morpholog1.29328532
62MP0002139_abnormal_hepatobiliary_system1.27594228
63MP0008260_abnormal_autophagy1.27455543
64MP0004947_skin_inflammation1.26557264
65MP0003077_abnormal_cell_cycle1.24880779
66MP0005375_adipose_tissue_phenotype1.24481852
67MP0005197_abnormal_uvea_morphology1.24231000
68MP0008932_abnormal_embryonic_tissue1.22958910
69MP0002277_abnormal_respiratory_mucosa1.22685476
70MP0005395_other_phenotype1.21184316
71MP0000678_abnormal_parathyroid_gland1.18701218
72MP0005360_urolithiasis1.17619518
73MP0009931_abnormal_skin_appearance1.16925001
74MP0000371_diluted_coat_color1.14526976
75MP0001191_abnormal_skin_condition1.13438660
76MP0000627_abnormal_mammary_gland1.11162470
77MP0004185_abnormal_adipocyte_glucose1.09459353
78MP0008004_abnormal_stomach_pH1.06543696
79MP0000566_synostosis1.05161474
80MP0005083_abnormal_biliary_tract1.03539378
81MP0001243_abnormal_dermal_layer1.00702126
82MP0005666_abnormal_adipose_tissue1.00142278
83MP0001919_abnormal_reproductive_system0.97446303
84MP0000858_altered_metastatic_potential0.95487384
85MP0009053_abnormal_anal_canal0.95353845
86MP0000367_abnormal_coat/_hair0.94966783
87MP0010094_abnormal_chromosome_stability0.94577176
88MP0002009_preneoplasia0.94296972
89MP0005365_abnormal_bile_salt0.94096315
90MP0003315_abnormal_perineum_morphology0.93454847
91MP0005076_abnormal_cell_differentiation0.91650347
92MP0001666_abnormal_nutrient_absorption0.91476175
93MP0002075_abnormal_coat/hair_pigmentati0.89221004
94MP0001851_eye_inflammation0.87338138
95MP0002138_abnormal_hepatobiliary_system0.86482307
96MP0003011_delayed_dark_adaptation0.84482661
97MP0001186_pigmentation_phenotype0.83681888
98MP0002295_abnormal_pulmonary_circulatio0.83474360
99MP0002234_abnormal_pharynx_morphology0.81979364
100MP0005397_hematopoietic_system_phenotyp0.80156475
101MP0001545_abnormal_hematopoietic_system0.80156475
102MP0005332_abnormal_amino_acid0.79173666
103MP0000427_abnormal_hair_cycle0.78603413
104MP0002896_abnormal_bone_mineralization0.78373225
105MP0002938_white_spotting0.77895638
106MP0005451_abnormal_body_composition0.77768044
107MP0005330_cardiomyopathy0.77500204
108MP0005193_abnormal_anterior_eye0.76880820
109MP0003091_abnormal_cell_migration0.76731376
110MP0000750_abnormal_muscle_regeneration0.76100464
111MP0000613_abnormal_salivary_gland0.75974846
112MP0000350_abnormal_cell_proliferation0.75120345
113MP0002111_abnormal_tail_morphology0.73932817
114MP0002970_abnormal_white_adipose0.73205225
115MP0003436_decreased_susceptibility_to0.72595993
116MP0005389_reproductive_system_phenotype0.72480232
117MP0009780_abnormal_chondrocyte_physiolo0.71514352
118MP0001764_abnormal_homeostasis0.70284251
119MP0003191_abnormal_cellular_cholesterol0.69717925
120MP0002282_abnormal_trachea_morphology0.69182453
121MP0005408_hypopigmentation0.68484437
122MP0004858_abnormal_nervous_system0.68376577
123MP0000470_abnormal_stomach_morphology0.68216742
124MP0002089_abnormal_postnatal_growth/wei0.68172347
125MP0000358_abnormal_cell_content/0.67850383
126MP0006138_congestive_heart_failure0.67690420
127MP0000639_abnormal_adrenal_gland0.66482172
128MP0002971_abnormal_brown_adipose0.65490757
129MP0010329_abnormal_lipoprotein_level0.65413311
130MP0003329_amyloid_beta_deposits0.65061531
131MP0003828_pulmonary_edema0.64805216
132MP0008058_abnormal_DNA_repair0.64231256
133MP0005508_abnormal_skeleton_morphology0.64175772
134MP0002019_abnormal_tumor_incidence0.63888211
135MP0001849_ear_inflammation0.62954010
136MP0002095_abnormal_skin_pigmentation0.62637601
137MP0001958_emphysema0.62606498
138MP0001881_abnormal_mammary_gland0.61934350
139MP0005084_abnormal_gallbladder_morpholo0.61442084
140MP0003638_abnormal_response/metabolism_0.61110216
141MP0005164_abnormal_response_to0.60853235
142MP0000343_altered_response_to0.60712687
143MP0009384_cardiac_valve_regurgitation0.59630335
144MP0003936_abnormal_reproductive_system0.59255094
145MP0008995_early_reproductive_senescence0.58811606
146MP0000537_abnormal_urethra_morphology0.58788889
147MP0005165_increased_susceptibility_to0.57687448
148MP0005266_abnormal_metabolism0.57124842

Predicted human phenotypes

RankGene SetZ-score
1Fragile nails (HP:0001808)5.08071237
2Abnormality of cells of the erythroid lineage (HP:0012130)4.44234862
3Reticulocytopenia (HP:0001896)4.36251283
4Vertebral compression fractures (HP:0002953)4.33947089
5Abnormal hemoglobin (HP:0011902)4.04894141
6Plantar hyperkeratosis (HP:0007556)3.93103638
7Sparse eyelashes (HP:0000653)3.75998879
8Macrocytic anemia (HP:0001972)3.74106660
9Abnormal number of erythroid precursors (HP:0012131)3.72469851
10Onycholysis (HP:0001806)3.69868108
11Distal lower limb muscle weakness (HP:0009053)3.57637656
12Congenital ichthyosiform erythroderma (HP:0007431)3.52665873
13Premature rupture of membranes (HP:0001788)3.50867763
14Hypotrichosis (HP:0001006)3.44201852
15Protrusio acetabuli (HP:0003179)3.42257449
16Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.34999543
17Breast hypoplasia (HP:0003187)3.30345636
18Nail dystrophy (HP:0008404)3.29641492
19Alopecia of scalp (HP:0002293)3.26895361
20White forelock (HP:0002211)3.22663662
21Palmoplantar hyperkeratosis (HP:0000972)3.16778816
22Right ventricular cardiomyopathy (HP:0011663)3.14540044
23Milia (HP:0001056)3.07029309
24Palmar hyperkeratosis (HP:0010765)3.05959796
25Premature ovarian failure (HP:0008209)3.04610404
26Woolly hair (HP:0002224)3.03525597
27Abnormality of liposaccharide metabolism (HP:0010968)3.03145013
28Abnormality of glycosphingolipid metabolism (HP:0004343)3.03145013
29Abnormality of glycolipid metabolism (HP:0010969)3.03145013
30Patchy hypopigmentation of hair (HP:0011365)2.98309672
31Abnormal blistering of the skin (HP:0008066)2.93006486
32Pallor (HP:0000980)2.91758369
33Rough bone trabeculation (HP:0100670)2.88820456
34Oral leukoplakia (HP:0002745)2.85600059
35Trismus (HP:0000211)2.83522379
36Elbow flexion contracture (HP:0002987)2.67080166
37Erythema (HP:0010783)2.60504773
38Abnormality of monocarboxylic acid metabolism (HP:0010996)2.57876396
39Axonal loss (HP:0003447)2.57528390
40Fragile skin (HP:0001030)2.55425999
41Parakeratosis (HP:0001036)2.55090175
42Secondary amenorrhea (HP:0000869)2.51655774
43Osteolytic defects of the phalanges of the hand (HP:0009771)2.50971570
44Osteolytic defects of the hand bones (HP:0009699)2.50971570
45Stenosis of the external auditory canal (HP:0000402)2.48707597
46Reduced subcutaneous adipose tissue (HP:0003758)2.48014266
47Abnormality of glycolysis (HP:0004366)2.47875287
48Concave nail (HP:0001598)2.46690312
49Ulnar bowing (HP:0003031)2.45199010
50Absent thumb (HP:0009777)2.43875312
51Aplasia/Hypoplasia of the sacrum (HP:0008517)2.37688531
52Congenital, generalized hypertrichosis (HP:0004540)2.37557182
53Abnormality of the umbilical cord (HP:0010881)2.36036351
54Abnormal trabecular bone morphology (HP:0100671)2.35148206
55Carpal bone hypoplasia (HP:0001498)2.35001773
56Fused cervical vertebrae (HP:0002949)2.33227290
57Cervical subluxation (HP:0003308)2.33054121
58Areflexia of lower limbs (HP:0002522)2.30545170
59Mitral stenosis (HP:0001718)2.29717195
60Lip pit (HP:0100267)2.29286028
61Acanthosis nigricans (HP:0000956)2.28927724
62Xanthomatosis (HP:0000991)2.28828266
6311 pairs of ribs (HP:0000878)2.26743055
64Abnormality of the distal phalanges of the toes (HP:0010182)2.26189020
65Abnormality of the axillary hair (HP:0100134)2.25454602
66Abnormality of secondary sexual hair (HP:0009888)2.25454602
67Atrophic scars (HP:0001075)2.25067673
68Esophageal atresia (HP:0002032)2.24603544
69Abnormalities of placenta or umbilical cord (HP:0001194)2.22727230
70Hypoalphalipoproteinemia (HP:0003233)2.21742993
71Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.21656990
72Abnormality of carpal bone ossification (HP:0006257)2.20399528
73Aplasia/hypoplasia of the uterus (HP:0008684)2.18525643
74Increased serum pyruvate (HP:0003542)2.18461708
75Abnormality of nail color (HP:0100643)2.16182457
76Erythroderma (HP:0001019)2.13933684
77Hypokinesia (HP:0002375)2.13521400
78Thick nail (HP:0001805)2.13177874
79Short nail (HP:0001799)2.09038758
80Epidermoid cyst (HP:0200040)2.07181148
81Hyperglycinuria (HP:0003108)2.06830172
82Birth length less than 3rd percentile (HP:0003561)2.06812423
83Absent radius (HP:0003974)2.05952615
84Popliteal pterygium (HP:0009756)2.05906887
85Ocular albinism (HP:0001107)2.04233639
86Upper limb amyotrophy (HP:0009129)2.03758556
87Distal upper limb amyotrophy (HP:0007149)2.03758556
88Distal lower limb amyotrophy (HP:0008944)2.03603005
89Abnormality of glutamine family amino acid metabolism (HP:0010902)2.03580843
90Vascular calcification (HP:0004934)2.02650005
91Amniotic constriction ring (HP:0009775)2.02556589
92Abnormality of placental membranes (HP:0011409)2.02556589
93Wormian bones (HP:0002645)2.02468051
94Cardiovascular calcification (HP:0011915)2.00773088
95Ankle contracture (HP:0006466)2.00250856
96Intrahepatic cholestasis (HP:0001406)2.00241124
97Multiple enchondromatosis (HP:0005701)1.99864583
98Advanced eruption of teeth (HP:0006288)1.98955740
99Pili torti (HP:0003777)1.98715838
100Hypohidrosis (HP:0000966)1.97275913
101Selective tooth agenesis (HP:0001592)1.95860310
102Conical tooth (HP:0000698)1.94774947
103Natal tooth (HP:0000695)1.94602359
104Abnormal ossification of hand bones (HP:0005921)1.94409191
105Absent forearm bone (HP:0003953)1.93434789
106Aplasia involving forearm bones (HP:0009822)1.93434789
107Hyperglycinemia (HP:0002154)1.92070658
108Abnormal umbilical cord blood vessels (HP:0011403)1.89391705
109Single umbilical artery (HP:0001195)1.89391705
110Abnormality of the fetal cardiovascular system (HP:0010948)1.89391705
111Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.89305575
112Decreased activity of mitochondrial respiratory chain (HP:0008972)1.89305575
113Hypobetalipoproteinemia (HP:0003563)1.88929664
114Abnormality of aromatic amino acid family metabolism (HP:0004338)1.88571790
115Ridged nail (HP:0001807)1.88553021
116Pustule (HP:0200039)1.88183138
117Entropion (HP:0000621)1.87972333
118Progressive muscle weakness (HP:0003323)1.87220089
119Abnormal hair laboratory examination (HP:0003328)1.86452874
120Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85246409
121Follicular hyperkeratosis (HP:0007502)1.85224135
122Abnormality of pyrimidine metabolism (HP:0004353)1.85203616
123Abnormality of the Achilles tendon (HP:0005109)1.84991214
124Thrombocytosis (HP:0001894)1.84107618
125Abnormality of the acetabulum (HP:0003170)1.83247864
126Achilles tendon contracture (HP:0001771)1.82365190
127Spastic paraparesis (HP:0002313)1.82236930
128Horseshoe kidney (HP:0000085)1.81777348
129Upper limb muscle weakness (HP:0003484)1.81204178
130Death in infancy (HP:0001522)1.81018653
131Pterygium (HP:0001059)1.80849993
132Prolonged neonatal jaundice (HP:0006579)1.80077886
133Anhidrosis (HP:0000970)1.79400421
134Myocardial infarction (HP:0001658)1.79009880
135Hypolipoproteinemia (HP:0010981)1.76510703
136Colon cancer (HP:0003003)1.76359928
137Missing ribs (HP:0000921)1.75305842
138Exertional dyspnea (HP:0002875)1.74965106
139Spinal cord compression (HP:0002176)1.74644009
140Sparse scalp hair (HP:0002209)1.74490261
141Ragged-red muscle fibers (HP:0003200)1.73753348
142Gout (HP:0001997)1.73270809
143Increased hepatocellular lipid droplets (HP:0006565)1.73204402
144Microretrognathia (HP:0000308)1.72526978
145Aplasia/Hypoplasia involving the musculature (HP:0001460)1.72318716
146Paraparesis (HP:0002385)1.71593401
147Iris hypopigmentation (HP:0007730)1.71027621
148Abnormality of alanine metabolism (HP:0010916)1.69945146
149Hyperalaninemia (HP:0003348)1.69945146
150Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69945146
151Increased connective tissue (HP:0009025)1.67565988
152Abnormal gallbladder physiology (HP:0012438)1.65400736
153Cholecystitis (HP:0001082)1.65400736
154Skin nodule (HP:0200036)1.64987062
155Tongue fasciculations (HP:0001308)1.62623680
156Cerebral aneurysm (HP:0004944)1.61801312
157Hypoplasia of dental enamel (HP:0006297)1.60877987
158Cerebral inclusion bodies (HP:0100314)1.60656161
159Generalized amyotrophy (HP:0003700)1.60160415
160Abnormal auditory evoked potentials (HP:0006958)1.59332335
161Dry hair (HP:0011359)1.59202873
162Abnormal hand bone ossification (HP:0010660)1.59136397

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.50002767
2PIM23.63813449
3BUB13.30315550
4WEE12.90426603
5NME22.83567754
6MST42.82274428
7RPS6KB22.69864598
8MAPKAPK32.57803793
9MAP3K32.56438992
10TESK12.31079705
11ZAK2.28308809
12MAP2K22.03917701
13PRPF4B1.85734050
14MAP3K111.85400741
15IRAK31.84903223
16LMTK21.83662802
17MST1R1.79772785
18DYRK31.63284837
19PTK21.61218371
20RPS6KA41.56923690
21SIK11.56130110
22BRSK21.55934796
23PLK41.52763579
24ICK1.50504448
25IKBKB1.46372656
26TRIB31.46081342
27EIF2AK11.45485832
28TESK21.45330157
29TLK11.45292980
30TTK1.42180555
31RIPK11.41205017
32NME11.39811704
33LRRK21.38846539
34VRK11.35730236
35MYLK1.35217383
36BCKDK1.33283338
37TSSK61.29416478
38STK101.28581928
39MAP3K141.26127834
40AURKA1.24568326
41ABL21.22468826
42FER1.19932941
43AURKB1.16200071
44PAK41.15103568
45DDR21.13604653
46STK161.11112408
47MOS1.10613428
48STK241.04736845
49SRPK11.04022317
50NEK11.03713826
51MAP3K81.03668209
52PLK11.00580609
53PDGFRA0.98629862
54NTRK10.97978368
55EIF2AK20.97842611
56LIMK10.94759976
57STK38L0.94705508
58DAPK30.92905857
59ARAF0.92614139
60PRKCI0.92611155
61TTN0.91465129
62TGFBR10.91447133
63BRAF0.91376668
64MAP3K90.90458337
65PIM10.89644331
66AKT30.88236611
67TGFBR20.86862250
68TYK20.86234680
69PLK30.85373626
70PDPK10.82673225
71SCYL20.81842308
72SMG10.80057047
73BMPR20.79497525
74NEK90.78965014
75RPS6KA50.77746916
76MAP3K20.76619217
77STK380.75691762
78EEF2K0.73819238
79AKT20.72866049
80MTOR0.71385381
81EPHB20.70736254
82MAPK150.69862455
83TAOK20.69196722
84PRKD30.69119789
85KDR0.68746255
86PRKG20.67883136
87MAPKAPK20.64940637
88LATS20.64833721
89ILK0.64261108
90PBK0.64063932
91PDK20.63705472
92PAK20.63548362
93CDK70.63485435
94CHUK0.62399377
95NEK60.61709590
96MAPKAPK50.61570982
97MAP3K120.61427312
98MAP2K60.60681316
99TRPM70.59502248
100ERBB30.59265810
101PAK10.58326560
102PRKD20.57190035
103GSK3A0.57001692
104BCR0.54412975
105BRSK10.53548452
106GRK50.52182225
107CAMK2G0.51887416
108MAP2K10.51496814
109ERN10.51148366
110FLT30.50737967
111MAP3K10.50248567
112EIF2AK30.49628608
113CSNK2A10.48096044
114LATS10.46148702
115MAPK110.45527842
116CAMKK20.44498299
117TAOK10.44117537
118MET0.43460306
119CSNK2A20.42732847
120MAPK40.41403065
121MAP2K30.41226929
122TBK10.40681975
123RPS6KA20.40062713
124MAPK70.38977994
125MUSK0.38219757
126MAP3K50.37476246
127CDK80.37279067
128CDK60.36339482
129PASK0.35983311
130RPS6KA10.35727244
131KSR20.34349550
132GRK70.32895788
133CHEK20.32697268
134RAF10.32271075
135CDK90.31893492
136ERBB40.31654750
137IRAK10.31119991
138BMX0.28889136
139ADRBK10.26064886
140CAMK2D0.25157913
141PTK60.24256225
142CDK120.24182983
143MELK0.24034531

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.74920447
2Proteasome_Homo sapiens_hsa030504.30564148
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.10995462
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.95081227
5RNA polymerase_Homo sapiens_hsa030202.85048769
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.29949001
7Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.28470279
8Other glycan degradation_Homo sapiens_hsa005112.10462032
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07323508
10Oxidative phosphorylation_Homo sapiens_hsa001902.05242633
11Pyrimidine metabolism_Homo sapiens_hsa002401.95155586
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.93234231
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.92514175
14Chemical carcinogenesis_Homo sapiens_hsa052041.92054242
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.90122404
16Folate biosynthesis_Homo sapiens_hsa007901.89367598
17Glutathione metabolism_Homo sapiens_hsa004801.87166467
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.84031391
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.80022551
20DNA replication_Homo sapiens_hsa030301.76413114
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.75055721
22One carbon pool by folate_Homo sapiens_hsa006701.74916995
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.70349141
24p53 signaling pathway_Homo sapiens_hsa041151.67459400
25Vibrio cholerae infection_Homo sapiens_hsa051101.66045058
26Phenylalanine metabolism_Homo sapiens_hsa003601.62188068
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.56022618
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.52418614
29Lysosome_Homo sapiens_hsa041421.51583903
30RNA transport_Homo sapiens_hsa030131.50646390
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.50509337
32Parkinsons disease_Homo sapiens_hsa050121.46014684
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40567726
34Spliceosome_Homo sapiens_hsa030401.40484043
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.36572234
36Retinol metabolism_Homo sapiens_hsa008301.35637781
37Nucleotide excision repair_Homo sapiens_hsa034201.34186844
38Huntingtons disease_Homo sapiens_hsa050161.32541075
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.28773464
40ECM-receptor interaction_Homo sapiens_hsa045121.28627191
41Mismatch repair_Homo sapiens_hsa034301.27681261
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25223620
43N-Glycan biosynthesis_Homo sapiens_hsa005101.21631568
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20448300
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19796518
46Steroid biosynthesis_Homo sapiens_hsa001001.19264058
47PPAR signaling pathway_Homo sapiens_hsa033201.17450298
48Arachidonic acid metabolism_Homo sapiens_hsa005901.16081092
49Central carbon metabolism in cancer_Homo sapiens_hsa052301.15585009
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14469405
51Biosynthesis of amino acids_Homo sapiens_hsa012301.14288361
52Bladder cancer_Homo sapiens_hsa052191.10452421
53Homologous recombination_Homo sapiens_hsa034401.10352707
54Fructose and mannose metabolism_Homo sapiens_hsa000511.09797072
55Tyrosine metabolism_Homo sapiens_hsa003501.09169881
56Base excision repair_Homo sapiens_hsa034101.07493774
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06742494
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04703081
59Sulfur relay system_Homo sapiens_hsa041221.03339543
60Prion diseases_Homo sapiens_hsa050201.03256188
61Mineral absorption_Homo sapiens_hsa049780.96491798
62Histidine metabolism_Homo sapiens_hsa003400.93877662
63Arginine biosynthesis_Homo sapiens_hsa002200.91205941
64Ovarian steroidogenesis_Homo sapiens_hsa049130.88888520
65Cell cycle_Homo sapiens_hsa041100.86793234
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.85976269
67Fatty acid biosynthesis_Homo sapiens_hsa000610.83728936
68Alzheimers disease_Homo sapiens_hsa050100.81688108
69Complement and coagulation cascades_Homo sapiens_hsa046100.79688730
70Carbon metabolism_Homo sapiens_hsa012000.78636859
71Linoleic acid metabolism_Homo sapiens_hsa005910.78152303
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77905217
73Epstein-Barr virus infection_Homo sapiens_hsa051690.77210975
74Purine metabolism_Homo sapiens_hsa002300.76054505
75Fatty acid metabolism_Homo sapiens_hsa012120.75456931
76Pentose phosphate pathway_Homo sapiens_hsa000300.74934061
77Vitamin B6 metabolism_Homo sapiens_hsa007500.74755639
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74286680
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73295541
80Basal transcription factors_Homo sapiens_hsa030220.71947312
81Arginine and proline metabolism_Homo sapiens_hsa003300.70170633
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69871932
83Synaptic vesicle cycle_Homo sapiens_hsa047210.67237700
84Fanconi anemia pathway_Homo sapiens_hsa034600.67108372
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66019673
86Metabolic pathways_Homo sapiens_hsa011000.64472117
87beta-Alanine metabolism_Homo sapiens_hsa004100.63289435
88Proteoglycans in cancer_Homo sapiens_hsa052050.63054089
89Focal adhesion_Homo sapiens_hsa045100.63034938
90Caffeine metabolism_Homo sapiens_hsa002320.62918600
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62307178
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62241718
93Galactose metabolism_Homo sapiens_hsa000520.62224374
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58411251
95RNA degradation_Homo sapiens_hsa030180.56169557
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55558481
97Peroxisome_Homo sapiens_hsa041460.54568225
98Fatty acid degradation_Homo sapiens_hsa000710.53032240
99Hippo signaling pathway_Homo sapiens_hsa043900.51597513
100Bile secretion_Homo sapiens_hsa049760.50110608
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49932863
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49064485
103Systemic lupus erythematosus_Homo sapiens_hsa053220.45890420
104Endocytosis_Homo sapiens_hsa041440.45827889
105Fatty acid elongation_Homo sapiens_hsa000620.44975291
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43330840
107Selenocompound metabolism_Homo sapiens_hsa004500.43188747
108Apoptosis_Homo sapiens_hsa042100.43055790
109Adherens junction_Homo sapiens_hsa045200.42070441
110Regulation of autophagy_Homo sapiens_hsa041400.41450818
111Amoebiasis_Homo sapiens_hsa051460.39351781
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37855168
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37002838
114Tryptophan metabolism_Homo sapiens_hsa003800.35140027
115Non-homologous end-joining_Homo sapiens_hsa034500.35138785
116Vitamin digestion and absorption_Homo sapiens_hsa049770.34610141
117Insulin signaling pathway_Homo sapiens_hsa049100.34523973
118Fat digestion and absorption_Homo sapiens_hsa049750.33489799
119Basal cell carcinoma_Homo sapiens_hsa052170.33122333
120HTLV-I infection_Homo sapiens_hsa051660.32587668
121Tight junction_Homo sapiens_hsa045300.31968903
122Sulfur metabolism_Homo sapiens_hsa009200.31397542
123AMPK signaling pathway_Homo sapiens_hsa041520.31130104
124Starch and sucrose metabolism_Homo sapiens_hsa005000.30746372
125Small cell lung cancer_Homo sapiens_hsa052220.30324917
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29124515
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28552274
128Collecting duct acid secretion_Homo sapiens_hsa049660.28391575
129Nitrogen metabolism_Homo sapiens_hsa009100.27356946
130Thyroid cancer_Homo sapiens_hsa052160.26308092
131Sphingolipid metabolism_Homo sapiens_hsa006000.24852417
132Pyruvate metabolism_Homo sapiens_hsa006200.19263623
133TGF-beta signaling pathway_Homo sapiens_hsa043500.19006738
134Cardiac muscle contraction_Homo sapiens_hsa042600.18203704

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