ATP8B5P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)6.75852459
2piRNA metabolic process (GO:0034587)6.56830066
3male meiosis I (GO:0007141)6.12433798
4protein neddylation (GO:0045116)4.79298281
5DNA deamination (GO:0045006)4.77329216
6male meiosis (GO:0007140)4.74932719
7meiosis I (GO:0007127)4.73056519
8DNA methylation involved in gamete generation (GO:0043046)4.71642217
9regulation of meiosis I (GO:0060631)4.70321231
10chromosome organization involved in meiosis (GO:0070192)4.53493530
11response to pheromone (GO:0019236)3.93323691
12behavioral response to nicotine (GO:0035095)3.82879175
13resolution of meiotic recombination intermediates (GO:0000712)3.74750854
14meiotic nuclear division (GO:0007126)3.54627755
15RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.48638798
16tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.48638798
17regulation of cilium movement (GO:0003352)3.42185400
18negative regulation of appetite (GO:0032099)3.41277601
19negative regulation of response to food (GO:0032096)3.41277601
20behavioral response to ethanol (GO:0048149)3.39601994
21platelet dense granule organization (GO:0060155)3.37655038
22DNA double-strand break processing (GO:0000729)3.36517583
23positive regulation of meiosis (GO:0045836)3.32441364
24synaptonemal complex organization (GO:0070193)3.30176817
25protein complex biogenesis (GO:0070271)3.29248017
26reciprocal meiotic recombination (GO:0007131)3.22763110
27reciprocal DNA recombination (GO:0035825)3.22763110
28synaptonemal complex assembly (GO:0007130)3.20722089
29cellular ketone body metabolic process (GO:0046950)3.19300500
30gene silencing by RNA (GO:0031047)3.15751823
31cytidine metabolic process (GO:0046087)3.15554625
32cytidine catabolic process (GO:0006216)3.15554625
33cytidine deamination (GO:0009972)3.15554625
34positive regulation of meiotic cell cycle (GO:0051446)3.15064804
35mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.13612948
36nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13232629
37signal peptide processing (GO:0006465)3.10708955
38nonmotile primary cilium assembly (GO:0035058)3.08320628
39RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.06368772
40fucose catabolic process (GO:0019317)3.05522735
41L-fucose metabolic process (GO:0042354)3.05522735
42L-fucose catabolic process (GO:0042355)3.05522735
43centriole replication (GO:0007099)3.03794237
44photoreceptor cell maintenance (GO:0045494)3.01160456
45meiotic cell cycle process (GO:1903046)2.97655863
46axoneme assembly (GO:0035082)2.90415300
47termination of RNA polymerase III transcription (GO:0006386)2.88762957
48transcription elongation from RNA polymerase III promoter (GO:0006385)2.88762957
49positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.88696478
50regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.87915737
51DNA synthesis involved in DNA repair (GO:0000731)2.85307628
52protein localization to cilium (GO:0061512)2.84109927
53ketone body metabolic process (GO:1902224)2.82464294
54proteasome assembly (GO:0043248)2.81610806
55regulation of activation of Janus kinase activity (GO:0010533)2.81001165
56mitochondrial respiratory chain complex assembly (GO:0033108)2.80727883
57epithelial cilium movement (GO:0003351)2.80179340
58regulation of memory T cell differentiation (GO:0043380)2.77222104
59mitochondrial respiratory chain complex I assembly (GO:0032981)2.76271160
60NADH dehydrogenase complex assembly (GO:0010257)2.76271160
61mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.76271160
62GPI anchor metabolic process (GO:0006505)2.75861592
63mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.75413506
64exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.75028684
65regulation of hexokinase activity (GO:1903299)2.73730191
66regulation of glucokinase activity (GO:0033131)2.73730191
67intraciliary transport (GO:0042073)2.70257803
68ATP synthesis coupled proton transport (GO:0015986)2.67678219
69energy coupled proton transport, down electrochemical gradient (GO:0015985)2.67678219
70detection of light stimulus involved in sensory perception (GO:0050962)2.66733671
71detection of light stimulus involved in visual perception (GO:0050908)2.66733671
72detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.62151139
73cytochrome complex assembly (GO:0017004)2.60761249
74microtubule severing (GO:0051013)2.60730709
75pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.60311875
76cullin deneddylation (GO:0010388)2.59794832
77regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.57763254
78pyrimidine ribonucleoside catabolic process (GO:0046133)2.56242427
79adaptation of signaling pathway (GO:0023058)2.55420125
80preassembly of GPI anchor in ER membrane (GO:0016254)2.52725374
81sequestering of actin monomers (GO:0042989)2.51047852
82positive regulation of cell fate commitment (GO:0010455)2.50476290
83replication fork processing (GO:0031297)2.50081802
84transmission of nerve impulse (GO:0019226)2.48225008
85reflex (GO:0060004)2.47094240
86protein deneddylation (GO:0000338)2.47034044
87single strand break repair (GO:0000012)2.46134308
88respiratory chain complex IV assembly (GO:0008535)2.44483644
89female gamete generation (GO:0007292)2.43435039
90ether lipid metabolic process (GO:0046485)2.42562846
91peptidyl-histidine modification (GO:0018202)2.42414223
92cilium morphogenesis (GO:0060271)2.42058959
93metallo-sulfur cluster assembly (GO:0031163)2.41760536
94iron-sulfur cluster assembly (GO:0016226)2.41760536
95spermatid development (GO:0007286)2.39446484
96water-soluble vitamin biosynthetic process (GO:0042364)2.37673219
97chromatin remodeling at centromere (GO:0031055)2.36448663
98protein targeting to peroxisome (GO:0006625)2.35017278
99establishment of protein localization to peroxisome (GO:0072663)2.35017278
100protein localization to peroxisome (GO:0072662)2.35017278

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.54757912
2VDR_22108803_ChIP-Seq_LS180_Human2.92413993
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.75277102
4TAF15_26573619_Chip-Seq_HEK293_Human2.65393716
5IGF1R_20145208_ChIP-Seq_DFB_Human2.64388265
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.48294199
7GBX2_23144817_ChIP-Seq_PC3_Human2.34703378
8EZH2_22144423_ChIP-Seq_EOC_Human2.32413780
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32379709
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.29934717
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.25089984
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.23755634
13EWS_26573619_Chip-Seq_HEK293_Human2.15594202
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.13705543
15FUS_26573619_Chip-Seq_HEK293_Human2.12368759
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04998125
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01604642
18P300_19829295_ChIP-Seq_ESCs_Human1.97399306
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97259485
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95878103
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.87542982
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86650345
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.84734569
24RNF2_27304074_Chip-Seq_NSC_Mouse1.83557109
25ER_23166858_ChIP-Seq_MCF-7_Human1.79932014
26BCAT_22108803_ChIP-Seq_LS180_Human1.77014942
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73826598
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.72684279
29CBP_20019798_ChIP-Seq_JUKART_Human1.72684279
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.69304712
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64624886
32TP53_22573176_ChIP-Seq_HFKS_Human1.62819010
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60004191
34NANOG_19829295_ChIP-Seq_ESCs_Human1.57842883
35SOX2_19829295_ChIP-Seq_ESCs_Human1.57842883
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57373187
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.57241377
38KLF5_20875108_ChIP-Seq_MESCs_Mouse1.51492655
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45215651
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41856199
41NCOR_22424771_ChIP-Seq_293T_Human1.39992888
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39540589
43VDR_23849224_ChIP-Seq_CD4+_Human1.38950742
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38458440
45SMAD4_21741376_ChIP-Seq_EPCs_Human1.35428435
46HTT_18923047_ChIP-ChIP_STHdh_Human1.34377498
47GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33542918
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.33467416
49AR_25329375_ChIP-Seq_VCAP_Human1.32612096
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.32423316
51FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.31866168
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.31709362
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31709362
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29587069
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29225401
56FOXA1_21572438_ChIP-Seq_LNCaP_Human1.28624307
57SMAD4_21799915_ChIP-Seq_A2780_Human1.28600732
58AUTS2_25519132_ChIP-Seq_293T-REX_Human1.28257521
59TCF4_22108803_ChIP-Seq_LS180_Human1.26732773
60STAT3_23295773_ChIP-Seq_U87_Human1.26390404
61MYC_18940864_ChIP-ChIP_HL60_Human1.26326421
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24049766
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.22635986
64IRF1_19129219_ChIP-ChIP_H3396_Human1.21763087
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21293426
66CDX2_22108803_ChIP-Seq_LS180_Human1.19283964
67TCF4_23295773_ChIP-Seq_U87_Human1.17358435
68RUNX2_22187159_ChIP-Seq_PCA_Human1.17174253
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.16881850
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16596176
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15847326
72PRDM14_20953172_ChIP-Seq_ESCs_Human1.14480225
73AR_20517297_ChIP-Seq_VCAP_Human1.12338374
74MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12283074
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11910674
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11502919
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10957949
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10952443
79E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10830873
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09796063
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09539347
82FOXH1_21741376_ChIP-Seq_EPCs_Human1.08400349
83JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.08328502
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.07337426
85REST_21632747_ChIP-Seq_MESCs_Mouse1.06767101
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06630813
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.06625879
88GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.06535640
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.06162487
90TAL1_26923725_Chip-Seq_HPCs_Mouse1.06027239
91ELK1_19687146_ChIP-ChIP_HELA_Human1.04420352
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04165145
93TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01987979
94ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01232674
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.00985977
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00854203
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00854203
98MYC_19829295_ChIP-Seq_ESCs_Human1.00586274
99STAT3_18555785_Chip-Seq_ESCs_Mouse0.99887310
100FLI1_21867929_ChIP-Seq_TH2_Mouse0.98807143

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.22828512
2MP0006292_abnormal_olfactory_placode2.76807533
3MP0001984_abnormal_olfaction2.63818628
4MP0002102_abnormal_ear_morphology2.36031895
5MP0001968_abnormal_touch/_nociception2.35340666
6MP0002736_abnormal_nociception_after2.28831389
7MP0003880_abnormal_central_pattern2.20895714
8MP0005551_abnormal_eye_electrophysiolog2.19778505
9MP0002160_abnormal_reproductive_system2.18138367
10MP0003195_calcinosis2.16593298
11MP0005646_abnormal_pituitary_gland2.16411831
12MP0003646_muscle_fatigue2.13358876
13MP0008789_abnormal_olfactory_epithelium2.06572672
14MP0005645_abnormal_hypothalamus_physiol2.02025209
15MP0002837_dystrophic_cardiac_calcinosis1.99231567
16MP0001485_abnormal_pinna_reflex1.90908639
17MP0005389_reproductive_system_phenotype1.78030013
18MP0002210_abnormal_sex_determination1.72720422
19MP0009046_muscle_twitch1.69936964
20MP0005084_abnormal_gallbladder_morpholo1.69395791
21MP0009745_abnormal_behavioral_response1.68860443
22MP0002272_abnormal_nervous_system1.68497526
23MP0002876_abnormal_thyroid_physiology1.67641967
24MP0001929_abnormal_gametogenesis1.63570671
25MP0008995_early_reproductive_senescence1.62597063
26MP0003787_abnormal_imprinting1.56609810
27MP0006276_abnormal_autonomic_nervous1.55684293
28MP0001529_abnormal_vocalization1.54346109
29MP0005394_taste/olfaction_phenotype1.54230784
30MP0005499_abnormal_olfactory_system1.54230784
31MP0008872_abnormal_physiological_respon1.49331284
32MP0004147_increased_porphyrin_level1.49289542
33MP0004142_abnormal_muscle_tone1.48363250
34MP0001501_abnormal_sleep_pattern1.46608057
35MP0003698_abnormal_male_reproductive1.46541805
36MP0003119_abnormal_digestive_system1.44595181
37MP0000372_irregular_coat_pigmentation1.43203969
38MP0000653_abnormal_sex_gland1.39688576
39MP0001905_abnormal_dopamine_level1.35808010
40MP0001145_abnormal_male_reproductive1.35199488
41MP0005410_abnormal_fertilization1.35066560
42MP0001486_abnormal_startle_reflex1.34464692
43MP0005253_abnormal_eye_physiology1.33122733
44MP0002234_abnormal_pharynx_morphology1.32602964
45MP0001970_abnormal_pain_threshold1.32375817
46MP0001188_hyperpigmentation1.31631920
47MP0005671_abnormal_response_to1.30350399
48MP0003136_yellow_coat_color1.29751300
49MP0006072_abnormal_retinal_apoptosis1.28854621
50MP0002733_abnormal_thermal_nociception1.26396106
51MP0008058_abnormal_DNA_repair1.26313046
52MP0003718_maternal_effect1.25139507
53MP0000049_abnormal_middle_ear1.25096568
54MP0002638_abnormal_pupillary_reflex1.25063527
55MP0000631_abnormal_neuroendocrine_gland1.24433462
56MP0005360_urolithiasis1.21916157
57MP0008004_abnormal_stomach_pH1.18097156
58MP0005367_renal/urinary_system_phenotyp1.17517293
59MP0000516_abnormal_urinary_system1.17517293
60MP0004133_heterotaxia1.16946111
61MP0010368_abnormal_lymphatic_system1.16839500
62MP0004885_abnormal_endolymph1.13738278
63MP0004145_abnormal_muscle_electrophysio1.12422170
64MP0001919_abnormal_reproductive_system1.10163853
65MP0004215_abnormal_myocardial_fiber1.08255380
66MP0003890_abnormal_embryonic-extraembry1.08137455
67MP0000427_abnormal_hair_cycle1.06489420
68MP0010386_abnormal_urinary_bladder1.05853845
69MP0003011_delayed_dark_adaptation1.02623771
70MP0005423_abnormal_somatic_nervous1.01551436
71MP0001764_abnormal_homeostasis1.01090066
72MP0002572_abnormal_emotion/affect_behav1.00166542
73MP0001119_abnormal_female_reproductive0.99801419
74MP0002163_abnormal_gland_morphology0.99316814
75MP0008057_abnormal_DNA_replication0.95262038
76MP0001986_abnormal_taste_sensitivity0.93543041
77MP0002184_abnormal_innervation0.93193342
78MP0005085_abnormal_gallbladder_physiolo0.93006983
79MP0000230_abnormal_systemic_arterial0.92917194
80MP0000569_abnormal_digit_pigmentation0.92473588
81MP0002735_abnormal_chemical_nociception0.92052538
82MP0002734_abnormal_mechanical_nocicepti0.91662817
83MP0002067_abnormal_sensory_capabilities0.91270300
84MP0006036_abnormal_mitochondrial_physio0.88456097
85MP0003937_abnormal_limbs/digits/tail_de0.87170718
86MP0003878_abnormal_ear_physiology0.86215446
87MP0005377_hearing/vestibular/ear_phenot0.86215446
88MP0005332_abnormal_amino_acid0.86022497
89MP0001963_abnormal_hearing_physiology0.85300403
90MP0001440_abnormal_grooming_behavior0.85013150
91MP0008875_abnormal_xenobiotic_pharmacok0.84959193
92MP0002095_abnormal_skin_pigmentation0.84266878
93MP0003786_premature_aging0.82735224
94MP0003635_abnormal_synaptic_transmissio0.82260336
95MP0002064_seizures0.82257673
96MP0003137_abnormal_impulse_conducting0.80747434
97MP0002752_abnormal_somatic_nervous0.79942484
98MP0000026_abnormal_inner_ear0.79491891
99MP0005636_abnormal_mineral_homeostasis0.78061430
100MP0009379_abnormal_foot_pigmentation0.77899731

Predicted human phenotypes

RankGene SetZ-score
1Medial flaring of the eyebrow (HP:0010747)3.37803762
2Abnormality of alanine metabolism (HP:0010916)3.35697608
3Hyperalaninemia (HP:0003348)3.35697608
4Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.35697608
5Acute necrotizing encephalopathy (HP:0006965)3.14297990
6Pancreatic cysts (HP:0001737)2.96897531
7Pancreatic fibrosis (HP:0100732)2.96746301
8Hyperglycinemia (HP:0002154)2.89498569
9Abolished electroretinogram (ERG) (HP:0000550)2.85580611
10Congenital, generalized hypertrichosis (HP:0004540)2.77798271
11Abnormality of the renal cortex (HP:0011035)2.75990555
12Abnormality of midbrain morphology (HP:0002418)2.75627748
13Molar tooth sign on MRI (HP:0002419)2.75627748
14Progressive macrocephaly (HP:0004481)2.75346644
15Acute encephalopathy (HP:0006846)2.75113024
16Congenital stationary night blindness (HP:0007642)2.74536343
17Abnormal mitochondria in muscle tissue (HP:0008316)2.71431736
18True hermaphroditism (HP:0010459)2.71016152
19Congenital primary aphakia (HP:0007707)2.67167251
20Gait imbalance (HP:0002141)2.66346409
21Increased CSF lactate (HP:0002490)2.61812383
22Intestinal atresia (HP:0011100)2.58866588
23Amyotrophic lateral sclerosis (HP:0007354)2.58185771
24Mitochondrial inheritance (HP:0001427)2.58166185
25Nephronophthisis (HP:0000090)2.54974795
26Nephrogenic diabetes insipidus (HP:0009806)2.45822119
273-Methylglutaconic aciduria (HP:0003535)2.39348080
28Abnormality of the lower motor neuron (HP:0002366)2.38674954
29Optic nerve hypoplasia (HP:0000609)2.35874015
30Renal cortical cysts (HP:0000803)2.32120590
31Abnormality of the renal medulla (HP:0100957)2.31994721
32Abnormality of serum amino acid levels (HP:0003112)2.30584723
33Gaze-evoked nystagmus (HP:0000640)2.30563505
34Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.29732090
35Cerebral edema (HP:0002181)2.28124880
36Hypoplasia of the uterus (HP:0000013)2.22600551
37Methylmalonic acidemia (HP:0002912)2.22483493
38Gonadotropin excess (HP:0000837)2.22391101
39Volvulus (HP:0002580)2.22100884
40Hepatocellular necrosis (HP:0001404)2.20732741
41Sclerocornea (HP:0000647)2.20493594
42Hepatic necrosis (HP:0002605)2.19685335
43Abnormal rod and cone electroretinograms (HP:0008323)2.18679408
44Attenuation of retinal blood vessels (HP:0007843)2.15145177
45Type II lissencephaly (HP:0007260)2.14796999
46Decreased central vision (HP:0007663)2.14770626
47Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14742621
48Ketosis (HP:0001946)2.08735311
49Genital tract atresia (HP:0001827)2.08322514
50Septo-optic dysplasia (HP:0100842)2.07951354
51Oligodactyly (hands) (HP:0001180)2.07634210
52Vaginal atresia (HP:0000148)2.04516365
53Abnormality of glycine metabolism (HP:0010895)2.03474252
54Abnormality of serine family amino acid metabolism (HP:0010894)2.03474252
55Methylmalonic aciduria (HP:0012120)1.99496287
56IgG deficiency (HP:0004315)1.98893003
57Cystic liver disease (HP:0006706)1.97961339
58Hypoproteinemia (HP:0003075)1.97429691
59Pancreatic islet-cell hyperplasia (HP:0004510)1.96936207
60Aplasia/hypoplasia of the uterus (HP:0008684)1.95703006
61Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.94848824
62Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93849497
63Abnormal protein N-linked glycosylation (HP:0012347)1.93849497
64Abnormal protein glycosylation (HP:0012346)1.93849497
65Abnormal glycosylation (HP:0012345)1.93849497
66Large for gestational age (HP:0001520)1.93177639
67Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.92974444
68Decreased electroretinogram (ERG) amplitude (HP:0000654)1.92645726
69Tubular atrophy (HP:0000092)1.91049267
70Hypomagnesemia (HP:0002917)1.90367366
71Genetic anticipation (HP:0003743)1.89413618
72Progressive cerebellar ataxia (HP:0002073)1.89093736
73Abnormality of the fovea (HP:0000493)1.87028292
74Abnormal drinking behavior (HP:0030082)1.85705925
75Polydipsia (HP:0001959)1.85705925
76Progressive inability to walk (HP:0002505)1.85458961
77Erythroderma (HP:0001019)1.85161594
78Poor coordination (HP:0002370)1.83493086
79Abnormality of macular pigmentation (HP:0008002)1.83176687
80Abnormal biliary tract physiology (HP:0012439)1.82824862
81Bile duct proliferation (HP:0001408)1.82824862
82Abnormality of the labia minora (HP:0012880)1.82574864
83Atrophy/Degeneration involving motor neurons (HP:0007373)1.81947201
84Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.81801225
85Degeneration of the lateral corticospinal tracts (HP:0002314)1.81801225
86Renal Fanconi syndrome (HP:0001994)1.81357862
87Abnormality of the phalanges of the 5th finger (HP:0004213)1.81160910
88Hyperglycinuria (HP:0003108)1.80529354
89Supernumerary spleens (HP:0009799)1.79441500
90Thyroiditis (HP:0100646)1.78695601
91Lethargy (HP:0001254)1.78570489
92Hypoplasia of the fovea (HP:0007750)1.76388743
93Aplasia/Hypoplasia of the fovea (HP:0008060)1.76388743
94Optic disc pallor (HP:0000543)1.75622698
95Lactic acidosis (HP:0003128)1.74197171
96Thyroid-stimulating hormone excess (HP:0002925)1.73929107
97Absent septum pellucidum (HP:0001331)1.73734898
98Inability to walk (HP:0002540)1.73533871
99Congenital hepatic fibrosis (HP:0002612)1.73015833
100Metaphyseal dysplasia (HP:0100255)1.71254718

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.68829868
2BMPR1B4.11955214
3ADRBK22.90770316
4ACVR1B2.73808757
5PINK12.67978253
6TXK2.45087739
7PNCK2.35836642
8BCKDK2.14681026
9TRIM282.13835214
10MAP4K22.10127783
11CDK191.94812333
12GRK11.90519558
13MST41.73440620
14WNK31.71964225
15MUSK1.70914474
16INSRR1.65500081
17PDK21.64168171
18ZAK1.61006011
19MAP3K41.44276837
20TAOK31.37478578
21MAPK131.36075922
22PASK1.35518552
23OXSR11.33519938
24KDR1.27444906
25TIE11.25547297
26PLK41.25512428
27ADRBK11.22358013
28NUAK11.21018148
29BCR1.20540357
30MAP3K91.20375625
31WNK41.16794184
32ERBB41.14970865
33STK31.14738248
34PRKCG1.13091713
35ARAF1.12261248
36PLK21.11972932
37STK161.11931122
38STK391.05114690
39MAP3K121.03786113
40WEE11.01528268
41VRK11.01469553
42MKNK21.01153077
43TLK11.00411560
44PRKCE1.00371859
45STK38L0.89388123
46CSNK1G30.88927364
47PIK3CA0.88214711
48DYRK20.86394347
49ITK0.85445977
50EPHA40.85339964
51PAK30.84757749
52TAF10.84749026
53CSNK1G20.84347993
54TGFBR10.83428908
55CSNK1G10.83284906
56NEK20.82576918
57TEC0.78695113
58MKNK10.78420005
59PRKCQ0.77591473
60MAP2K70.76516902
61OBSCN0.74608976
62DYRK30.72613847
63PLK10.68852247
64MINK10.66924421
65MAP3K130.64663551
66PRKCI0.64598082
67BRAF0.64539540
68LIMK10.63774698
69CAMK2A0.61965669
70PHKG20.59430925
71PHKG10.59430925
72CSF1R0.54432426
73MAP2K60.54113005
74PTK2B0.51548854
75PIK3CG0.50662988
76CASK0.50001488
77STK110.48555284
78TNK20.46573181
79PRKACA0.44142549
80PRKCA0.42853815
81IGF1R0.42490536
82NEK90.42370715
83ERBB30.41385322
84PLK30.41357076
85CSNK1A1L0.40254484
86CAMK2D0.39159212
87IKBKB0.36833515
88PKN10.35834874
89PRKG10.35662869
90FGFR20.34351563
91CDK30.33904968
92TNIK0.33891764
93PIM20.33666866
94RPS6KA50.31863619
95CSNK2A10.31346666
96EGFR0.31172987
97RPS6KA40.31014887
98CSNK2A20.28041570
99MYLK0.28033110
100VRK20.27410811

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.17447494
2Oxidative phosphorylation_Homo sapiens_hsa001903.05534183
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.69626643
4Parkinsons disease_Homo sapiens_hsa050122.69438740
5Phototransduction_Homo sapiens_hsa047442.68412409
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.64653011
7RNA polymerase_Homo sapiens_hsa030202.55150158
8Propanoate metabolism_Homo sapiens_hsa006402.36414098
9Proteasome_Homo sapiens_hsa030502.25492041
10Butanoate metabolism_Homo sapiens_hsa006502.13471890
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.13228894
12Ribosome_Homo sapiens_hsa030102.09694761
13Homologous recombination_Homo sapiens_hsa034401.84509464
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79424185
15Basal transcription factors_Homo sapiens_hsa030221.79312601
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.75862440
17RNA degradation_Homo sapiens_hsa030181.71983770
18Huntingtons disease_Homo sapiens_hsa050161.68453922
19Nitrogen metabolism_Homo sapiens_hsa009101.59343105
20Alzheimers disease_Homo sapiens_hsa050101.58680336
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58642774
22Linoleic acid metabolism_Homo sapiens_hsa005911.55258145
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.53944302
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.52667997
25Peroxisome_Homo sapiens_hsa041461.48537217
26Fanconi anemia pathway_Homo sapiens_hsa034601.44882464
27Cardiac muscle contraction_Homo sapiens_hsa042601.43973279
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.41645214
29Nicotine addiction_Homo sapiens_hsa050331.41287463
30Regulation of autophagy_Homo sapiens_hsa041401.40759373
31Olfactory transduction_Homo sapiens_hsa047401.38703520
32Selenocompound metabolism_Homo sapiens_hsa004501.29263440
33Retinol metabolism_Homo sapiens_hsa008301.22426418
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17758865
35Nucleotide excision repair_Homo sapiens_hsa034201.16650647
36Tryptophan metabolism_Homo sapiens_hsa003801.13280755
37Taste transduction_Homo sapiens_hsa047421.11792203
38Primary immunodeficiency_Homo sapiens_hsa053401.11703531
39beta-Alanine metabolism_Homo sapiens_hsa004101.11655675
40Steroid biosynthesis_Homo sapiens_hsa001001.10756764
41ABC transporters_Homo sapiens_hsa020101.09301363
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07370456
43Collecting duct acid secretion_Homo sapiens_hsa049661.06996750
44Pyrimidine metabolism_Homo sapiens_hsa002401.06354883
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01552523
46Purine metabolism_Homo sapiens_hsa002301.00253967
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94716055
48Mismatch repair_Homo sapiens_hsa034300.93436661
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92809477
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89286604
51Fat digestion and absorption_Homo sapiens_hsa049750.88280649
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88134171
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.83371995
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.83046272
55Morphine addiction_Homo sapiens_hsa050320.82999918
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82578788
57Ether lipid metabolism_Homo sapiens_hsa005650.79219314
58Non-homologous end-joining_Homo sapiens_hsa034500.78313770
59Type I diabetes mellitus_Homo sapiens_hsa049400.76309317
60RNA transport_Homo sapiens_hsa030130.75033482
61Fatty acid degradation_Homo sapiens_hsa000710.73993273
62Circadian entrainment_Homo sapiens_hsa047130.73388794
63Metabolic pathways_Homo sapiens_hsa011000.72528210
64Oocyte meiosis_Homo sapiens_hsa041140.72393899
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72293615
66Arachidonic acid metabolism_Homo sapiens_hsa005900.72227244
67Chemical carcinogenesis_Homo sapiens_hsa052040.71966238
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71143532
69Sulfur metabolism_Homo sapiens_hsa009200.69934022
70Serotonergic synapse_Homo sapiens_hsa047260.69874540
71Graft-versus-host disease_Homo sapiens_hsa053320.69693812
72GABAergic synapse_Homo sapiens_hsa047270.69008402
73Fatty acid elongation_Homo sapiens_hsa000620.63585166
74Caffeine metabolism_Homo sapiens_hsa002320.63509921
75Base excision repair_Homo sapiens_hsa034100.63423763
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62470322
77Insulin secretion_Homo sapiens_hsa049110.61092725
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57920296
79Rheumatoid arthritis_Homo sapiens_hsa053230.55576475
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55050404
81Fatty acid metabolism_Homo sapiens_hsa012120.54199306
82Asthma_Homo sapiens_hsa053100.51220357
83Salivary secretion_Homo sapiens_hsa049700.49263876
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48986389
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48765584
86Allograft rejection_Homo sapiens_hsa053300.48298854
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47690194
88Calcium signaling pathway_Homo sapiens_hsa040200.46023527
89Autoimmune thyroid disease_Homo sapiens_hsa053200.45939099
90Dopaminergic synapse_Homo sapiens_hsa047280.43380856
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41512715
92Circadian rhythm_Homo sapiens_hsa047100.41372394
93Glutamatergic synapse_Homo sapiens_hsa047240.41145297
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.40589387
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39963601
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39788536
97Ovarian steroidogenesis_Homo sapiens_hsa049130.39272716
98Dorso-ventral axis formation_Homo sapiens_hsa043200.38167778
99Glycerolipid metabolism_Homo sapiens_hsa005610.38064779
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34541958

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