ATP8B3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to the other. This gene encodes member 3 of phospholipid-transporting ATPase 8B; other members of this protein family are located on chromosomes 1, 15 and 18. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.95726553
2axonemal dynein complex assembly (GO:0070286)9.91881718
3* binding of sperm to zona pellucida (GO:0007339)9.86410071
4spermatid development (GO:0007286)9.80901517
5epithelial cilium movement (GO:0003351)9.79835994
6* cell-cell recognition (GO:0009988)9.76875159
7plasma membrane fusion (GO:0045026)9.58851928
8motile cilium assembly (GO:0044458)9.31617924
9regulation of cilium movement (GO:0003352)8.53949627
10reproduction (GO:0000003)8.50604551
11cilium movement (GO:0003341)8.18246914
12piRNA metabolic process (GO:0034587)7.65064078
13synaptonemal complex organization (GO:0070193)7.46119295
14sperm capacitation (GO:0048240)7.35366478
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.33072154
16synaptonemal complex assembly (GO:0007130)7.29069918
17male meiosis (GO:0007140)7.20315208
18organic cation transport (GO:0015695)7.12530907
19single fertilization (GO:0007338)6.98596311
20negative regulation of inclusion body assembly (GO:0090084)6.87663106
21spermatogenesis (GO:0007283)6.76357044
22male gamete generation (GO:0048232)6.73875995
23gamete generation (GO:0007276)6.18257526
24fertilization (GO:0009566)6.15710599
25regulation of inclusion body assembly (GO:0090083)5.85747006
26microtubule depolymerization (GO:0007019)5.70073365
27cellular process involved in reproduction in multicellular organism (GO:0022412)5.63977295
28germ cell development (GO:0007281)5.58659807
29ventricular system development (GO:0021591)5.50018369
30calcium ion-dependent exocytosis (GO:0017156)5.49862867
31chromosome condensation (GO:0030261)5.40881223
32DNA packaging (GO:0006323)5.34435690
33male meiosis I (GO:0007141)5.31253563
34seminiferous tubule development (GO:0072520)5.24834099
35microtubule severing (GO:0051013)5.13312808
36behavioral response to nicotine (GO:0035095)5.10136239
37regulation of microtubule-based movement (GO:0060632)5.07643853
38response to pheromone (GO:0019236)4.86877455
39multicellular organismal reproductive process (GO:0048609)4.86091281
40DNA methylation involved in gamete generation (GO:0043046)4.85257387
41chromosome organization involved in meiosis (GO:0070192)4.84607621
42left/right pattern formation (GO:0060972)4.81280065
43L-fucose catabolic process (GO:0042355)4.70609957
44fucose catabolic process (GO:0019317)4.70609957
45L-fucose metabolic process (GO:0042354)4.70609957
46* cell recognition (GO:0008037)4.67446757
47sequestering of actin monomers (GO:0042989)4.59562168
48meiotic nuclear division (GO:0007126)4.44521719
49meiosis I (GO:0007127)4.27705493
50water-soluble vitamin biosynthetic process (GO:0042364)4.21659019
51spermatid nucleus differentiation (GO:0007289)4.19729901
52DNA deamination (GO:0045006)4.12904604
53glycerol ether metabolic process (GO:0006662)4.03886175
54protein localization to cilium (GO:0061512)3.98663448
55protein polyglutamylation (GO:0018095)3.95806274
56genitalia morphogenesis (GO:0035112)3.93025748
57multicellular organismal development (GO:0007275)3.90611293
58chaperone-mediated protein complex assembly (GO:0051131)3.86184146
59kynurenine metabolic process (GO:0070189)3.83084659
60RNA localization (GO:0006403)3.76407907
61meiotic cell cycle (GO:0051321)3.73329869
62ether metabolic process (GO:0018904)3.72495607
63cellular ketone body metabolic process (GO:0046950)3.69436605
64protein K6-linked ubiquitination (GO:0085020)3.69221955
65protein complex biogenesis (GO:0070271)3.68560125
66indole-containing compound catabolic process (GO:0042436)3.62493933
67indolalkylamine catabolic process (GO:0046218)3.62493933
68tryptophan catabolic process (GO:0006569)3.62493933
69platelet dense granule organization (GO:0060155)3.60103442
70RNA destabilization (GO:0050779)3.59954042
71indolalkylamine metabolic process (GO:0006586)3.57362085
72cytochrome complex assembly (GO:0017004)3.54586210
73respiratory chain complex IV assembly (GO:0008535)3.53306487
74carnitine transport (GO:0015879)3.51902893
75amino-acid betaine transport (GO:0015838)3.51902893
76rRNA catabolic process (GO:0016075)3.50242200
77mitochondrial respiratory chain complex assembly (GO:0033108)3.46889226
78mitochondrial respiratory chain complex I assembly (GO:0032981)3.46105932
79NADH dehydrogenase complex assembly (GO:0010257)3.46105932
80mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.46105932
81regulation of spindle checkpoint (GO:0090231)3.44283757
82sexual reproduction (GO:0019953)3.42677542
83positive regulation of macrophage activation (GO:0043032)3.38968490
84carnitine transmembrane transport (GO:1902603)3.37067243
85ketone body metabolic process (GO:1902224)3.35937542
86preassembly of GPI anchor in ER membrane (GO:0016254)3.34153806
87monoubiquitinated protein deubiquitination (GO:0035520)3.32913286
88detection of light stimulus involved in visual perception (GO:0050908)3.31769063
89detection of light stimulus involved in sensory perception (GO:0050962)3.31769063
90meiotic chromosome segregation (GO:0045132)3.31034810
91negative regulation of telomere maintenance (GO:0032205)3.31032882
92negative regulation of mast cell activation (GO:0033004)3.30326503
93protein refolding (GO:0042026)3.29890228
94single strand break repair (GO:0000012)3.28819993
95interferon-gamma secretion (GO:0072643)3.28190689
96mannosylation (GO:0097502)3.26363039
97tryptophan metabolic process (GO:0006568)3.23387549
98negative regulation of organelle assembly (GO:1902116)3.19590162
99nucleus organization (GO:0006997)3.17266210
100axoneme assembly (GO:0035082)3.13340196
101reciprocal meiotic recombination (GO:0007131)3.12950465
102reciprocal DNA recombination (GO:0035825)3.12950465
103polyamine biosynthetic process (GO:0006596)3.11230347
104recombinational repair (GO:0000725)3.05318811
105regulation of memory T cell differentiation (GO:0043380)3.02980298
106double-strand break repair via homologous recombination (GO:0000724)3.02499571
107intraciliary transport (GO:0042073)3.01212817
108regulation of hexokinase activity (GO:1903299)3.00127685
109regulation of glucokinase activity (GO:0033131)3.00127685
110microtubule-based movement (GO:0007018)2.98025646
111replication fork processing (GO:0031297)2.96468391
112centriole replication (GO:0007099)2.96373706
113detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.96092822
114protein-DNA complex disassembly (GO:0032986)2.94946750
115nucleosome disassembly (GO:0006337)2.94946750
116protein K11-linked deubiquitination (GO:0035871)2.93771462
117maturation of 5.8S rRNA (GO:0000460)2.91068073
118meiotic cell cycle process (GO:1903046)2.90239661
119peptidyl-glutamic acid modification (GO:0018200)2.90181954
120mitotic sister chromatid cohesion (GO:0007064)2.89372333
121microtubule polymerization or depolymerization (GO:0031109)2.87129360
122nonmotile primary cilium assembly (GO:0035058)2.85490841
123cilium organization (GO:0044782)2.84346917
124protein-cofactor linkage (GO:0018065)2.83630950
125DNA double-strand break processing (GO:0000729)2.82495130
126glycolytic process (GO:0006096)2.81886591
127regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.80066387
128regulation of cilium assembly (GO:1902017)2.79111963
129regulation of nuclear cell cycle DNA replication (GO:0033262)2.76142522
130nucleoside diphosphate phosphorylation (GO:0006165)2.74230115
131cilium morphogenesis (GO:0060271)2.73101566
132resolution of meiotic recombination intermediates (GO:0000712)2.72667714
133regulation of action potential (GO:0098900)2.71516057
134polyol catabolic process (GO:0046174)2.70202648
135cilium assembly (GO:0042384)2.69686218
136gene silencing by RNA (GO:0031047)2.69601186
137neural tube formation (GO:0001841)2.68978036
138regulation of hippo signaling (GO:0035330)2.68765658
139lactate metabolic process (GO:0006089)2.68176493
140cellular component assembly involved in morphogenesis (GO:0010927)2.67308287
141alditol metabolic process (GO:0019400)2.67043138
142synapsis (GO:0007129)2.61900264
143nuclear pore complex assembly (GO:0051292)2.61886938
144adaptation of signaling pathway (GO:0023058)2.61383046
145L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.60714577
146amine catabolic process (GO:0009310)2.60387362
147cellular biogenic amine catabolic process (GO:0042402)2.60387362
148ubiquinone biosynthetic process (GO:0006744)2.59908991
149indole-containing compound metabolic process (GO:0042430)2.59475365
150cellular response to ATP (GO:0071318)2.58410914
151response to acidic pH (GO:0010447)2.56891643
152RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.56693384
153tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.56693384
154RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.55205155
155peptidyl-histidine modification (GO:0018202)2.54431358
156C-terminal protein lipidation (GO:0006501)2.53511730
157S-adenosylmethionine metabolic process (GO:0046500)2.53279221
158regulation of telomere maintenance (GO:0032204)2.53173770
159photoreceptor cell development (GO:0042461)2.52860707
160pseudouridine synthesis (GO:0001522)2.51312676
161tRNA processing (GO:0008033)2.51074933
162tRNA modification (GO:0006400)2.50444562
163cornea development in camera-type eye (GO:0061303)2.49453102
164synaptic transmission, cholinergic (GO:0007271)2.49443737
165photoreceptor cell maintenance (GO:0045494)2.48534567
166kidney morphogenesis (GO:0060993)2.48418552
167GPI anchor metabolic process (GO:0006505)2.47540260
168establishment of protein localization to mitochondrial membrane (GO:0090151)2.44391860
169behavioral response to ethanol (GO:0048149)2.43712211
170retinal cone cell development (GO:0046549)2.42343289
171glycerophospholipid catabolic process (GO:0046475)2.41578786
172positive regulation of triglyceride biosynthetic process (GO:0010867)2.40742838
173somatic hypermutation of immunoglobulin genes (GO:0016446)2.39298192
174sperm motility (GO:0030317)13.4343778
175fusion of sperm to egg plasma membrane (GO:0007342)12.5977254
176cell wall macromolecule metabolic process (GO:0044036)12.3946326
177cell wall macromolecule catabolic process (GO:0016998)12.3946326
178acrosome reaction (GO:0007340)12.3554981
179acrosome assembly (GO:0001675)10.9865383
180* sperm-egg recognition (GO:0035036)10.9482441
181cilium or flagellum-dependent cell motility (GO:0001539)10.3933787

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.83587781
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.73681079
3STAT6_21828071_ChIP-Seq_BEAS2B_Human2.99282554
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.95368183
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.86343587
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.71034833
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.47746310
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46079946
9CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.43441585
10IGF1R_20145208_ChIP-Seq_DFB_Human2.37028691
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.36296869
12GBX2_23144817_ChIP-Seq_PC3_Human2.33418547
13GATA1_26923725_Chip-Seq_HPCs_Mouse2.28932572
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.18033322
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16524399
16FUS_26573619_Chip-Seq_HEK293_Human2.11584888
17ZNF274_21170338_ChIP-Seq_K562_Hela2.07991810
18VDR_22108803_ChIP-Seq_LS180_Human2.06808376
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.06040640
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.05958209
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.04297420
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00460516
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00023039
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.3249833
25EWS_26573619_Chip-Seq_HEK293_Human1.98146477
26ER_23166858_ChIP-Seq_MCF-7_Human1.94113349
27ELK4_26923725_Chip-Seq_MESODERM_Mouse1.92149630
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.92111496
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.87470744
30FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83738373
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.82078892
32MYC_18940864_ChIP-ChIP_HL60_Human1.81075568
33IRF1_19129219_ChIP-ChIP_H3396_Human1.78251646
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.70949278
35P300_19829295_ChIP-Seq_ESCs_Human1.70786061
36TAF15_26573619_Chip-Seq_HEK293_Human1.70571762
37TP53_22573176_ChIP-Seq_HFKS_Human1.67202566
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.63558414
39SOX2_22085726_ChIP-Seq_NPCs_Mouse1.62669675
40VDR_23849224_ChIP-Seq_CD4+_Human1.62378955
41STAT1_17558387_ChIP-Seq_HELA_Human1.60351067
42ELK1_19687146_ChIP-ChIP_HELA_Human1.57421708
43WDR5_24793694_ChIP-Seq_LNCAP_Human1.55369530
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.54939867
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53756920
46* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.52177794
47MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.51473954
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.49281187
49ETV2_25802403_ChIP-Seq_MESCs_Mouse1.49149505
50* GATA3_21867929_ChIP-Seq_CD8_Mouse1.48670126
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48439530
52CBP_20019798_ChIP-Seq_JUKART_Human1.48439530
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.47509592
54FOXA1_27270436_Chip-Seq_PROSTATE_Human1.47509592
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43969318
56BCAT_22108803_ChIP-Seq_LS180_Human1.42980393
57* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.42971896
58* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.42873769
59* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.40564031
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.39692653
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38905481
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.38846217
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38742590
64NANOG_19829295_ChIP-Seq_ESCs_Human1.38268105
65SOX2_19829295_ChIP-Seq_ESCs_Human1.38268105
66P53_21459846_ChIP-Seq_SAOS-2_Human1.37927081
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37344315
68NCOR_22424771_ChIP-Seq_293T_Human1.36535837
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.36511883
70PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.36461242
71STAT3_23295773_ChIP-Seq_U87_Human1.35819363
72AR_20517297_ChIP-Seq_VCAP_Human1.34171691
73REST_21632747_ChIP-Seq_MESCs_Mouse1.31618071
74SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.31309997
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29927468
76CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.29635179
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27004958
78* LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.26179438
79TCF4_23295773_ChIP-Seq_U87_Human1.26162849
80RAD21_21589869_ChIP-Seq_MESCs_Mouse1.25970227
81TAL1_26923725_Chip-Seq_HPCs_Mouse1.24745074
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24185151
83KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23914583
84ERA_21632823_ChIP-Seq_H3396_Human1.23192229
85FOXP3_21729870_ChIP-Seq_TREG_Human1.22415565
86HOXB7_26014856_ChIP-Seq_BT474_Human1.22040607
87TCF4_22108803_ChIP-Seq_LS180_Human1.21969593
88SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.19321374
89AR_25329375_ChIP-Seq_VCAP_Human1.19240390
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19036631
91KDM2B_26808549_Chip-Seq_REH_Human1.18198038
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17996286
93SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17745018
94FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17280326
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16440269
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15826851
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15304933
98ERG_20517297_ChIP-Seq_VCAP_Human1.14913550
99TET1_21451524_ChIP-Seq_MESCs_Mouse1.14623886
100CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14394529
101ELF1_20517297_ChIP-Seq_JURKAT_Human1.14214705
102GF1_26923725_Chip-Seq_HPCs_Mouse1.13843362
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12300331
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12288324
105* MYC_19829295_ChIP-Seq_ESCs_Human1.11997577
106MYC_27129775_Chip-Seq_CORNEA_Mouse1.11466936
107AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11135474
108RARA_24833708_ChIP-Seq_LIVER_Mouse1.10540953
109* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10304234
110YY1_22570637_ChIP-Seq_MALME-3M_Human1.09988381
111PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.09829579
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08868510
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08868510
114CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08513326
115TP63_19390658_ChIP-ChIP_HaCaT_Human1.08250376
116* CTCF_20526341_ChIP-Seq_ESCs_Human1.08009519
117RUNX1_26923725_Chip-Seq_HPCs_Mouse1.07895658
118* FLI1_21867929_ChIP-Seq_TH2_Mouse1.07279616
119SPI1_26923725_Chip-Seq_HPCs_Mouse1.05813432
120RXRA_24833708_ChIP-Seq_LIVER_Mouse1.05294488
121SMAD4_21799915_ChIP-Seq_A2780_Human1.05292306
122CBX2_27304074_Chip-Seq_ESCs_Mouse1.05007435
123PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05004660
124GATA1_19941827_ChIP-Seq_MEL86_Mouse1.04937690
125* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03982189
126SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03188863
127BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03033755
128TAF2_19829295_ChIP-Seq_ESCs_Human1.02931008
129CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02866581
130RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02750625
131* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02013021
132PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01415663
133KAP1_22055183_ChIP-Seq_ESCs_Mouse1.01207568
134NFE2_27457419_Chip-Seq_LIVER_Mouse1.00897780
135AR_21572438_ChIP-Seq_LNCaP_Human1.00892388
136CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00658926
137RUNX2_22187159_ChIP-Seq_PCA_Human1.00468633
138* GATA3_21867929_ChIP-Seq_TH1_Mouse1.00238028
139ESET_19884257_ChIP-Seq_ESCs_Mouse1.00226586
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00093872
141SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99496098
142SOX11_22085726_ChIP-Seq_ESNs_Mouse0.98815994
143EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98758514
144JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.98696702
145EZH2_27294783_Chip-Seq_NPCs_Mouse0.98637230
146NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98103853
147EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97694638
148SOX2_21211035_ChIP-Seq_LN229_Human0.97018282
149E2F4_17652178_ChIP-ChIP_JURKAT_Human0.96588860
150FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95829873
151TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95675275
152E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95365300
153RNF2_27304074_Chip-Seq_NSC_Mouse0.95014677
154OCT4_20526341_ChIP-Seq_ESCs_Human0.94814560
155LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94639329
156TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94550080
157EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93743210
158PIAS1_25552417_ChIP-Seq_VCAP_Human0.93588580
159PHF8_20622854_ChIP-Seq_HELA_Human0.92870922
160FLI1_21867929_ChIP-Seq_CD8_Mouse0.92754893
161NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91610816
162PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90920621
163ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90436378
164* BCOR_27268052_Chip-Seq_Bcells_Human0.88800673
165CTCF_27219007_Chip-Seq_Bcells_Human0.87230139
166RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85790895
167CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.85082939
168SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84681642
169BCL6_27268052_Chip-Seq_Bcells_Human0.84537714
170NANOG_20526341_ChIP-Seq_ESCs_Human0.84437197
171NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.83333039
172NANOG_18555785_Chip-Seq_ESCs_Mouse0.83193688
173SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82472202
174CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.82392331
175PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82034356
176* CRX_20693478_ChIP-Seq_RETINA_Mouse0.81416294
177* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80961647

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.97477528
2MP0001929_abnormal_gametogenesis5.55304456
3MP0008877_abnormal_DNA_methylation3.85132461
4MP0002210_abnormal_sex_determination3.37917477
5* MP0002161_abnormal_fertility/fecundity3.22349040
6MP0003195_calcinosis3.07582837
7MP0001145_abnormal_male_reproductive2.92946500
8MP0006292_abnormal_olfactory_placode2.70550751
9MP0005670_abnormal_white_adipose2.69812086
10MP0000653_abnormal_sex_gland2.52393469
11MP0002653_abnormal_ependyma_morphology2.45921569
12MP0006072_abnormal_retinal_apoptosis2.42964691
13MP0003646_muscle_fatigue2.26508620
14MP0002160_abnormal_reproductive_system2.17207230
15MP0002102_abnormal_ear_morphology2.16525935
16MP0000372_irregular_coat_pigmentation2.07717148
17MP0005174_abnormal_tail_pigmentation2.07347186
18* MP0005410_abnormal_fertilization16.3470493
19MP0005645_abnormal_hypothalamus_physiol1.98862716
20MP0005084_abnormal_gallbladder_morpholo1.96327916
21MP0003136_yellow_coat_color1.94245031
22MP0004147_increased_porphyrin_level1.87013112
23MP0002938_white_spotting1.86439016
24MP0002837_dystrophic_cardiac_calcinosis1.86343245
25MP0005646_abnormal_pituitary_gland1.78703303
26MP0001986_abnormal_taste_sensitivity1.76933461
27MP0004233_abnormal_muscle_weight1.75426230
28MP0001968_abnormal_touch/_nociception1.73155928
29MP0008872_abnormal_physiological_respon1.67555930
30MP0004885_abnormal_endolymph1.66695228
31MP0000427_abnormal_hair_cycle1.63838281
32MP0005623_abnormal_meninges_morphology1.62555396
33MP0004142_abnormal_muscle_tone1.60294795
34MP0003121_genomic_imprinting1.57113242
35MP0005379_endocrine/exocrine_gland_phen1.55402638
36MP0002163_abnormal_gland_morphology1.48686806
37MP0002876_abnormal_thyroid_physiology1.43997915
38MP0003718_maternal_effect1.40452897
39MP0009745_abnormal_behavioral_response1.39844673
40MP0000631_abnormal_neuroendocrine_gland1.35273948
41MP0002095_abnormal_skin_pigmentation1.32033561
42MP0000015_abnormal_ear_pigmentation1.31820876
43MP0001529_abnormal_vocalization1.27151387
44MP0003252_abnormal_bile_duct1.26472878
45MP0005075_abnormal_melanosome_morpholog1.25039466
46MP0001919_abnormal_reproductive_system1.23202891
47MP0002138_abnormal_hepatobiliary_system1.19775182
48MP0001485_abnormal_pinna_reflex1.17488988
49MP0005083_abnormal_biliary_tract1.16350667
50MP0002272_abnormal_nervous_system1.16252496
51MP0001501_abnormal_sleep_pattern1.14102141
52MP0002282_abnormal_trachea_morphology1.13596825
53MP0002638_abnormal_pupillary_reflex1.07969885
54MP0005389_reproductive_system_phenotype1.05917765
55MP0008789_abnormal_olfactory_epithelium1.03673138
56MP0001486_abnormal_startle_reflex1.02774664
57MP0005195_abnormal_posterior_eye1.00807041
58MP0003283_abnormal_digestive_organ0.99796521
59MP0001984_abnormal_olfaction0.99643859
60MP0005332_abnormal_amino_acid0.96764731
61MP0002557_abnormal_social/conspecific_i0.96082554
62MP0003122_maternal_imprinting0.95921302
63MP0008775_abnormal_heart_ventricle0.94250928
64MP0001765_abnormal_ion_homeostasis0.92004363
65MP0006276_abnormal_autonomic_nervous0.91397432
66MP0005085_abnormal_gallbladder_physiolo0.90782124
67MP0002693_abnormal_pancreas_physiology0.90689153
68MP0002733_abnormal_thermal_nociception0.85786074
69MP0000383_abnormal_hair_follicle0.82351751
70MP0001970_abnormal_pain_threshold0.81872900
71MP0005647_abnormal_sex_gland0.81329003
72MP0003186_abnormal_redox_activity0.81242555
73MP0003115_abnormal_respiratory_system0.81194562
74MP0002572_abnormal_emotion/affect_behav0.80117362
75MP0009046_muscle_twitch0.79746560
76MP0002234_abnormal_pharynx_morphology0.77614061
77MP0002752_abnormal_somatic_nervous0.76813123
78MP0002067_abnormal_sensory_capabilities0.76244814
79MP0000026_abnormal_inner_ear0.76138854
80MP0001944_abnormal_pancreas_morphology0.74195660
81MP0002751_abnormal_autonomic_nervous0.74172394
82MP0005386_behavior/neurological_phenoty0.73969600
83MP0004924_abnormal_behavior0.73969600
84MP0002064_seizures0.73711984
85MP0005377_hearing/vestibular/ear_phenot0.68855999
86MP0003878_abnormal_ear_physiology0.68855999
87MP0008995_early_reproductive_senescence0.66955673
88MP0003011_delayed_dark_adaptation0.65492289
89MP0000358_abnormal_cell_content/0.65382348
90MP0003329_amyloid_beta_deposits0.64556167
91MP0008058_abnormal_DNA_repair0.62076529
92MP0006036_abnormal_mitochondrial_physio0.61941025
93MP0009278_abnormal_bone_marrow0.59906491
94MP0001545_abnormal_hematopoietic_system0.57410635
95MP0005397_hematopoietic_system_phenotyp0.57410635
96MP0005666_abnormal_adipose_tissue0.57232052
97MP0004036_abnormal_muscle_relaxation0.56269636
98MP0010094_abnormal_chromosome_stability0.53252930
99MP0002269_muscular_atrophy0.51216245
100MP0005636_abnormal_mineral_homeostasis0.51190284
101MP0003950_abnormal_plasma_membrane0.49844244
102MP0001661_extended_life_span0.48460039
103MP0000569_abnormal_digit_pigmentation0.48128701
104MP0001293_anophthalmia0.47651253
105MP0003699_abnormal_female_reproductive0.46993046
106MP0000534_abnormal_ureter_morphology0.44419733
107MP0001324_abnormal_eye_pigmentation0.44402059
108MP0000751_myopathy0.39322726
109MP0003787_abnormal_imprinting0.38789215
110MP0004811_abnormal_neuron_physiology0.38711342
111MP0002928_abnormal_bile_duct0.38016834
112MP0008007_abnormal_cellular_replicative0.37588671
113MP0003111_abnormal_nucleus_morphology0.35372281
114MP0006035_abnormal_mitochondrial_morpho0.34721652
115MP0001730_embryonic_growth_arrest0.34662852
116MP0003942_abnormal_urinary_system0.34021948
117MP0003879_abnormal_hair_cell0.33203685
118MP0000604_amyloidosis0.32628302
119MP0009115_abnormal_fat_cell0.32064721
120MP0001764_abnormal_homeostasis0.31976534
121MP0008057_abnormal_DNA_replication0.29621257
122MP0005253_abnormal_eye_physiology0.29354938
123MP0004133_heterotaxia0.29265025
124MP0005391_vision/eye_phenotype0.29185676
125MP0000749_muscle_degeneration0.28606199
126MP0003861_abnormal_nervous_system0.28557308
127MP0004270_analgesia0.28516021
128MP0005551_abnormal_eye_electrophysiolog0.27511808
129MP0002152_abnormal_brain_morphology0.27115035
130MP0003633_abnormal_nervous_system0.26476422
131MP0002971_abnormal_brown_adipose0.26063271
132MP0003786_premature_aging0.24854518
133MP0008961_abnormal_basal_metabolism0.24425856
134MP0002736_abnormal_nociception_after0.24409441
135MP0003948_abnormal_gas_homeostasis0.24208658
136MP0002139_abnormal_hepatobiliary_system0.23996533
137MP0002092_abnormal_eye_morphology0.23265808
138MP0003959_abnormal_lean_body0.23145614
139MP0002295_abnormal_pulmonary_circulatio0.23076354
140MP0002084_abnormal_developmental_patter0.22615470
141MP0003631_nervous_system_phenotype0.22020274
142MP0004808_abnormal_hematopoietic_stem0.21799368
143MP0000313_abnormal_cell_death0.21502125
144MP0002169_no_abnormal_phenotype0.21241116
145MP0004019_abnormal_vitamin_homeostasis0.21193753
146MP0002873_normal_phenotype0.21012783
147MP0001727_abnormal_embryo_implantation0.20954899
148MP0002108_abnormal_muscle_morphology0.19202161
149MP0002909_abnormal_adrenal_gland0.19201210
150MP0010307_abnormal_tumor_latency0.19158747
151MP0005375_adipose_tissue_phenotype0.18361671
152MP0001119_abnormal_female_reproductive0.18298404
153MP0002796_impaired_skin_barrier0.18030286
154MP0003936_abnormal_reproductive_system0.17741635
155MP0003045_fibrosis0.17682567
156MP0001849_ear_inflammation0.16753961
157MP0004087_abnormal_muscle_fiber0.16118663
158MP0001697_abnormal_embryo_size0.15966926
159MP0004043_abnormal_pH_regulation0.15350295
160MP0008875_abnormal_xenobiotic_pharmacok0.15344180
161MP0002229_neurodegeneration0.15258565
162MP0004742_abnormal_vestibular_system0.14590838

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.04236259
2Abnormal respiratory motile cilium morphology (HP:0005938)8.77212339
3Abnormal respiratory epithelium morphology (HP:0012253)8.77212339
4Rhinitis (HP:0012384)7.84541017
5Chronic bronchitis (HP:0004469)7.19165817
6Infertility (HP:0000789)7.11590508
7Abnormal ciliary motility (HP:0012262)6.81068395
8Nasal polyposis (HP:0100582)6.59754036
9Abnormality of the nasal mucosa (HP:0000433)5.43034219
10Nephronophthisis (HP:0000090)4.73613426
11Bronchitis (HP:0012387)4.64604199
12Bronchiectasis (HP:0002110)4.60385812
13Pancreatic cysts (HP:0001737)4.56532837
14Pancreatic fibrosis (HP:0100732)4.24674216
15Male infertility (HP:0003251)4.16227095
16Congenital stationary night blindness (HP:0007642)4.02464362
17True hermaphroditism (HP:0010459)3.88306633
18Abnormality of the renal medulla (HP:0100957)3.55055323
19Abnormal spermatogenesis (HP:0008669)3.52273989
20Type II lissencephaly (HP:0007260)3.39039685
21Recurrent otitis media (HP:0000403)3.38417620
22Abnormality of alanine metabolism (HP:0010916)3.23414753
23Hyperalaninemia (HP:0003348)3.23414753
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.23414753
25Pendular nystagmus (HP:0012043)3.19824546
26Chronic hepatic failure (HP:0100626)3.11682645
27Attenuation of retinal blood vessels (HP:0007843)3.05415555
28Impulsivity (HP:0100710)3.00159900
29Recurrent bronchitis (HP:0002837)2.94896454
30Tubulointerstitial nephritis (HP:0001970)2.91204519
31Recurrent sinusitis (HP:0011108)2.90032713
32Abnormal rod and cone electroretinograms (HP:0008323)2.88116175
33Tubular atrophy (HP:0000092)2.84134198
34Gonadotropin excess (HP:0000837)2.79392096
35Cholecystitis (HP:0001082)2.72667475
36Abnormal gallbladder physiology (HP:0012438)2.72667475
37Tubulointerstitial abnormality (HP:0001969)2.66045930
38Abnormality of midbrain morphology (HP:0002418)2.61326517
39Molar tooth sign on MRI (HP:0002419)2.61326517
40Sclerocornea (HP:0000647)2.59256972
41Azoospermia (HP:0000027)2.53757345
42Abolished electroretinogram (ERG) (HP:0000550)2.52108928
43Severe visual impairment (HP:0001141)2.49486088
44Absent rod-and cone-mediated responses on ERG (HP:0007688)2.47997887
45Gaze-evoked nystagmus (HP:0000640)2.44569102
46Large for gestational age (HP:0001520)2.40796793
47Increased corneal curvature (HP:0100692)2.33768576
48Keratoconus (HP:0000563)2.33768576
49Rib fusion (HP:0000902)2.32050885
50Anencephaly (HP:0002323)2.30410044
51Lissencephaly (HP:0001339)2.28865791
52Tubulointerstitial fibrosis (HP:0005576)2.28474686
53Hypoplasia of the fovea (HP:0007750)2.28266851
54Aplasia/Hypoplasia of the fovea (HP:0008060)2.28266851
55Abnormal number of erythroid precursors (HP:0012131)2.27705974
56Abnormality of the lower motor neuron (HP:0002366)2.26763971
57Hypoplasia of the capital femoral epiphysis (HP:0003090)2.26472649
58Aplasia/Hypoplasia of the tongue (HP:0010295)2.24291270
59Increased CSF lactate (HP:0002490)2.21734256
60Hyperventilation (HP:0002883)2.19234551
61Medial flaring of the eyebrow (HP:0010747)2.17326066
62Methylmalonic acidemia (HP:0002912)2.15201613
63Renal cortical cysts (HP:0000803)2.13924820
64Mitochondrial inheritance (HP:0001427)2.13603893
65Spastic tetraparesis (HP:0001285)2.12391711
66Dyschromatopsia (HP:0007641)2.12386648
67Furrowed tongue (HP:0000221)2.10827500
68Severe muscular hypotonia (HP:0006829)2.10516460
69Choroideremia (HP:0001139)2.09957972
70Progressive cerebellar ataxia (HP:0002073)2.09878717
71Retinal dysplasia (HP:0007973)2.08469665
723-Methylglutaconic aciduria (HP:0003535)2.05873767
73Methylmalonic aciduria (HP:0012120)2.05668649
74Patellar aplasia (HP:0006443)2.05183173
75Aplasia/Hypoplasia of the uvula (HP:0010293)2.03703927
76Bony spicule pigmentary retinopathy (HP:0007737)2.03431474
77Genetic anticipation (HP:0003743)2.02440919
78Polydipsia (HP:0001959)2.01535957
79Abnormal drinking behavior (HP:0030082)2.01535957
80Chorioretinal atrophy (HP:0000533)2.00563931
81Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1219527
82Dynein arm defect of respiratory motile cilia (HP:0012255)12.4593469
83Absent/shortened dynein arms (HP:0200106)12.4593469
84Acute necrotizing encephalopathy (HP:0006965)1.99837937
85Aplasia/Hypoplasia of the patella (HP:0006498)1.99559756
86Stage 5 chronic kidney disease (HP:0003774)1.98603304
87Abnormality of the pons (HP:0007361)1.97869662
88Occipital encephalocele (HP:0002085)1.95137665
89Ketosis (HP:0001946)1.94987214
90Concave nail (HP:0001598)1.94623147
91Abnormality of the fovea (HP:0000493)1.94535266
92Gait imbalance (HP:0002141)1.94376708
93Postaxial foot polydactyly (HP:0001830)1.92823425
94Inability to walk (HP:0002540)1.92357092
95Hepatocellular necrosis (HP:0001404)1.90520692
96Abnormality of macular pigmentation (HP:0008002)1.89983453
97Congenital primary aphakia (HP:0007707)1.89440012
98Heterotopia (HP:0002282)1.87060925
99Increased serum lactate (HP:0002151)1.86108840
100Hypoplasia of the pons (HP:0012110)1.85080522
101Ketoacidosis (HP:0001993)1.84641708
102Male pseudohermaphroditism (HP:0000037)1.83782823
103Amyotrophic lateral sclerosis (HP:0007354)1.83558270
104Hypothermia (HP:0002045)1.81156286
105Short ribs (HP:0000773)1.80989649
106Abnormality of the ileum (HP:0001549)1.79530504
107Hepatic necrosis (HP:0002605)1.79259486
108Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.79120230
109Absent epiphyses (HP:0010577)1.79120230
110Pachygyria (HP:0001302)1.79055437
111Nephrogenic diabetes insipidus (HP:0009806)1.78718725
112Bell-shaped thorax (HP:0001591)1.77706932
113Congenital hepatic fibrosis (HP:0002612)1.76549089
114Sloping forehead (HP:0000340)1.76448226
115Acute encephalopathy (HP:0006846)1.75798583
116Neurofibrillary tangles (HP:0002185)1.75787566
117Lipid accumulation in hepatocytes (HP:0006561)1.75151455
118Meckel diverticulum (HP:0002245)1.75067236
119Progressive macrocephaly (HP:0004481)1.74327990
120Absent thumb (HP:0009777)1.74275764
121Small hand (HP:0200055)1.74200077
122Congenital malformation of the right heart (HP:0011723)1.74096867
123Double outlet right ventricle (HP:0001719)1.74096867
124Abnormality of the renal cortex (HP:0011035)1.74051459
125Abnormality of renal excretion (HP:0011036)1.73648219
126Renal dysplasia (HP:0000110)1.71760101
127Abnormality of cells of the erythroid lineage (HP:0012130)1.71619784
128Optic disc pallor (HP:0000543)1.71383869
129Fibular hypoplasia (HP:0003038)1.70668959
130Preaxial hand polydactyly (HP:0001177)1.70393143
131Optic nerve hypoplasia (HP:0000609)1.69605533
132Abnormality of the labia minora (HP:0012880)1.69302272
133Congenital, generalized hypertrichosis (HP:0004540)1.69199104
134Congenital sensorineural hearing impairment (HP:0008527)1.69035460
135Hemorrhage of the eye (HP:0011885)1.68712975
136Decreased central vision (HP:0007663)1.68077912
137Oculomotor apraxia (HP:0000657)1.65325638
138Abnormality of dentin (HP:0010299)1.63608659
139Impaired proprioception (HP:0010831)1.62190080
140Bile duct proliferation (HP:0001408)1.55657627
141Abnormal biliary tract physiology (HP:0012439)1.55657627
142Abnormality of permanent molar morphology (HP:0011071)1.55313990
143Abnormality of the dental root (HP:0006486)1.55313990
144Taurodontia (HP:0000679)1.55313990
145Absent frontal sinuses (HP:0002688)1.52433452
146Abnormal urine output (HP:0012590)1.47807840
147Short femoral neck (HP:0100864)1.47302536
148Loss of speech (HP:0002371)1.47254419
149Deformed sella turcica (HP:0002681)1.45845650
150Cerebral inclusion bodies (HP:0100314)1.45172359
151Decreased electroretinogram (ERG) amplitude (HP:0000654)1.44507383
152Postaxial hand polydactyly (HP:0001162)1.43309288
153Broad distal phalanx of finger (HP:0009836)1.42715304
154J-shaped sella turcica (HP:0002680)1.42639980
155Hemiparesis (HP:0001269)1.42487436
156Abnormality of molar (HP:0011077)1.42464030
157Abnormality of molar morphology (HP:0011070)1.42464030
158Abnormality of the dental pulp (HP:0006479)1.42210988
159Short thorax (HP:0010306)1.36780352
160Cerebellar dysplasia (HP:0007033)1.36537990
161Facial cleft (HP:0002006)1.34899732
162Difficulty climbing stairs (HP:0003551)1.33621261
163Nephropathy (HP:0000112)1.33379229
164Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.33019714
165Asymmetric septal hypertrophy (HP:0001670)1.29976952
166Easy fatigability (HP:0003388)1.29798222
167Aplasia/Hypoplasia of the lens (HP:0008063)1.28928760
168Microglossia (HP:0000171)1.28468875
169Fatigable weakness (HP:0003473)1.27161933
170Abnormality of the neuromuscular junction (HP:0003398)1.27161933
171Bundle branch block (HP:0011710)1.25723151
172Polyuria (HP:0000103)1.25555845
173Myoglobinuria (HP:0002913)1.24732858
174Exercise-induced myalgia (HP:0003738)1.24443778
175Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.24139688
176EMG: neuropathic changes (HP:0003445)1.24012504
177Cystic liver disease (HP:0006706)1.23607525
178Chronic sinusitis (HP:0011109)1.22373612

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK18.11784666
2PDK37.01702788
3PDK47.01702788
4PRKD35.50339460
5FRK5.48119962
6ICK4.92838829
7PDK24.50576061
8BMPR1B3.48090577
9MAP4K23.35485272
10ADRBK22.97435285
11NUAK12.84280069
12ZAK2.76820555
13PTK2B2.59724071
14GRK12.31902047
15ACVR1B2.30388018
16STK382.27667332
17WNK42.24417498
18TLK12.23913426
19STK392.16764741
20PNCK2.13387205
21NEK22.01380776
22TAOK31.91385429
23MAPK131.83471074
24INSRR1.73650180
25OXSR11.64257409
26DYRK1B1.59491423
27EIF2AK31.39437804
28VRK21.34869086
29PRKCI1.21068766
30PDK11.20078414
31CASK1.19040136
32ADRBK11.18262466
33BUB11.18125654
34TXK1.15553529
35MST41.12442848
36BCKDK1.11653646
37VRK11.09256122
38TGFBR11.06918689
39TNIK1.02572442
40DAPK21.01488737
41DYRK20.99904844
42NTRK30.98078051
43FLT30.97992072
44TYRO30.95810115
45MAPK150.94617487
46WNK10.93127943
47EEF2K0.89020799
48DYRK30.88456492
49MAPKAPK30.87362322
50TAF10.86866538
51PRKCE0.84180292
52PASK0.84076831
53PDPK10.83065380
54PAK30.82134046
55PLK30.81449128
56CAMKK20.78000937
57PLK20.77444949
58TRIM280.77031333
59STK160.75386461
60MKNK20.74716128
61TIE10.74285801
62STK30.73293282
63IRAK10.72451711
64MAP2K70.71356473
65PINK10.70232743
66CCNB10.69796580
67TNK20.69373503
68CSNK1G20.69177076
69TESK20.67593321
70ERBB30.67388726
71TTK0.66648946
72IKBKB0.63492818
73FGFR20.62705255
74TEC0.61809696
75CSNK1G10.60622068
76CAMK1G0.60057982
77RIPK40.59594282
78CSNK1G30.58002109
79SIK20.57854786
80RPS6KA50.54957722
81CHEK20.54083803
82KIT0.52634091
83IRAK20.52541834
84PHKG20.50672450
85PHKG10.50672450
86EIF2AK20.49557343
87MARK10.46785485
88MUSK0.43286271
89NTRK20.43140759
90EIF2AK10.42686836
91CSNK1A1L0.42282742
92CDK190.41771387
93BCR0.40858999
94PAK10.39943475
95MAP2K60.39649989
96PAK20.39438261
97MTOR0.37462068
98GRK70.35768309
99CDK80.35695637
100CHEK10.35278261
101PRKACA0.35220951
102PRKCG0.35208147
103CSNK1A10.34797693
104CAMKK10.33222976
105LMTK20.33087082
106PAK40.32941404
107MARK20.32416137
108ATR0.30703788
109ATM0.29041787
110PRKAA10.27755450
111WEE10.26965067
112GRK60.26642651
113NME10.26403366
114RPS6KB10.25815042
115MAP3K100.25153582
116NEK60.23032539
117MAPKAPK50.22211970
118STK38L0.21213275
119CDC70.19441520
120CSF1R0.16076837
121PRKCZ0.15605052
122PRKCQ0.14164037
123PAK60.12334084
124RPS6KA10.12283258
125PLK10.11569962
126TRIB30.10389736
127CDK150.09599661
128CDK180.07097258
129GSK3B0.06744157
130CLK10.06345239
131CDK11A0.05947298
132BRAF0.05191948
133STK110.04914034
134PLK40.04414801
135CSNK1D0.04221045
136CSNK2A10.04188422
137STK100.03980268
138CAMK2A0.03759161
139PRKACG0.03493777
140MAPK80.03428181
141CDK20.03279844
142CDK140.02961404
143PIM10.02932773
144CDK60.02535452
145CDK10.02463253
146EPHB10.02145990
147PRKCB0.01480037
148BRSK10.01193319
149MAP3K40.00337071
150BRSK20.00031917
151MAP3K5-0.0416223
152MAP3K1-0.0413885
153WNK3-0.0371019
154CDK4-0.0354336
155PRKDC-0.0310229
156PRKACB-0.0242337
157AURKA-0.0227206
158CSNK2A2-0.0219377
159EGFR-0.0191968
160PRKCD-0.0154965
161PRKCA-0.0126734
162MARK3-0.0120764
163RPS6KA3-0.0110599
164PKN1-0.0077044
165PRKG1-0.0049577
166PRKG2-0.0021901

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.46364139
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.09526339
3Pyruvate metabolism_Homo sapiens_hsa006203.40524988
4Vitamin B6 metabolism_Homo sapiens_hsa007503.25987743
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.16918451
6Linoleic acid metabolism_Homo sapiens_hsa005913.03992435
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.96963974
8Glucagon signaling pathway_Homo sapiens_hsa049222.66363585
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.66219309
10Phototransduction_Homo sapiens_hsa047442.60728980
11Propanoate metabolism_Homo sapiens_hsa006402.60391830
12Homologous recombination_Homo sapiens_hsa034402.53369877
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.53352251
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.51477483
15Butanoate metabolism_Homo sapiens_hsa006502.48871084
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.42842991
17Selenocompound metabolism_Homo sapiens_hsa004502.39858194
18Carbohydrate digestion and absorption_Homo sapiens_hsa049732.37575842
19Nitrogen metabolism_Homo sapiens_hsa009102.30572804
20RNA polymerase_Homo sapiens_hsa030202.27144767
21Maturity onset diabetes of the young_Homo sapiens_hsa049502.10009884
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.08332849
23Oxidative phosphorylation_Homo sapiens_hsa001902.04412308
24Glycerolipid metabolism_Homo sapiens_hsa005612.03435897
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.01572880
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.98055432
27Basal transcription factors_Homo sapiens_hsa030221.96631779
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.90602524
29PPAR signaling pathway_Homo sapiens_hsa033201.89665551
30Protein export_Homo sapiens_hsa030601.83927043
31Amphetamine addiction_Homo sapiens_hsa050311.81981722
32One carbon pool by folate_Homo sapiens_hsa006701.81718878
33Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.81007895
34Dorso-ventral axis formation_Homo sapiens_hsa043201.79492552
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.79296097
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.75743302
37Oocyte meiosis_Homo sapiens_hsa041141.69653570
38Caffeine metabolism_Homo sapiens_hsa002321.60037198
39Fat digestion and absorption_Homo sapiens_hsa049751.59532291
40Fructose and mannose metabolism_Homo sapiens_hsa000511.57407062
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.55564390
42Tryptophan metabolism_Homo sapiens_hsa003801.55117144
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.53715383
44Olfactory transduction_Homo sapiens_hsa047401.52913859
45Pentose phosphate pathway_Homo sapiens_hsa000301.49760209
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49607267
47Cardiac muscle contraction_Homo sapiens_hsa042601.49509558
48Parkinsons disease_Homo sapiens_hsa050121.49059797
49Fatty acid metabolism_Homo sapiens_hsa012121.44476820
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43467194
51Fatty acid degradation_Homo sapiens_hsa000711.40710516
52Ether lipid metabolism_Homo sapiens_hsa005651.40331327
53RNA degradation_Homo sapiens_hsa030181.39864716
54Fanconi anemia pathway_Homo sapiens_hsa034601.37870952
55Peroxisome_Homo sapiens_hsa041461.31646960
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.30946421
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.29831089
58Carbon metabolism_Homo sapiens_hsa012001.26989637
59Huntingtons disease_Homo sapiens_hsa050161.25997381
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25824689
61Nicotine addiction_Homo sapiens_hsa050331.24824106
62Regulation of autophagy_Homo sapiens_hsa041401.23957428
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22313574
64Glutathione metabolism_Homo sapiens_hsa004801.21968622
65Systemic lupus erythematosus_Homo sapiens_hsa053221.21957518
66Cysteine and methionine metabolism_Homo sapiens_hsa002701.20672266
67Renin secretion_Homo sapiens_hsa049241.20025689
68Mineral absorption_Homo sapiens_hsa049781.18539249
69Non-homologous end-joining_Homo sapiens_hsa034501.16566273
70Pyrimidine metabolism_Homo sapiens_hsa002401.12030470
71mRNA surveillance pathway_Homo sapiens_hsa030151.07052435
72Steroid hormone biosynthesis_Homo sapiens_hsa001401.03715933
73Glycosaminoglycan degradation_Homo sapiens_hsa005311.03282376
74Antigen processing and presentation_Homo sapiens_hsa046121.02006017
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99938882
76Sulfur relay system_Homo sapiens_hsa041220.98612431
77Sulfur metabolism_Homo sapiens_hsa009200.97911469
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97507495
79Proteasome_Homo sapiens_hsa030500.95574443
80Long-term potentiation_Homo sapiens_hsa047200.94402910
81Hedgehog signaling pathway_Homo sapiens_hsa043400.94335441
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.93248615
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89321502
84Retinol metabolism_Homo sapiens_hsa008300.88634741
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85121116
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84749012
87Estrogen signaling pathway_Homo sapiens_hsa049150.83959007
88Alzheimers disease_Homo sapiens_hsa050100.83599219
89Purine metabolism_Homo sapiens_hsa002300.83172184
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.82771047
91Nucleotide excision repair_Homo sapiens_hsa034200.81847636
92RNA transport_Homo sapiens_hsa030130.81036606
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80423688
94Alcoholism_Homo sapiens_hsa050340.79767046
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78794066
96Insulin secretion_Homo sapiens_hsa049110.78260977
97Collecting duct acid secretion_Homo sapiens_hsa049660.76733344
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76174633
99Lysine degradation_Homo sapiens_hsa003100.74322976
100Arachidonic acid metabolism_Homo sapiens_hsa005900.73044279
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.72812235
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72056806
103Morphine addiction_Homo sapiens_hsa050320.72013353
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71797654
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68877003
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68874005
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68787246
108Thyroid hormone synthesis_Homo sapiens_hsa049180.67934114
109Bile secretion_Homo sapiens_hsa049760.67045010
110Chemical carcinogenesis_Homo sapiens_hsa052040.65583038
111ABC transporters_Homo sapiens_hsa020100.63802591
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63424662
113AMPK signaling pathway_Homo sapiens_hsa041520.62498233
114Base excision repair_Homo sapiens_hsa034100.62137459
115Biosynthesis of amino acids_Homo sapiens_hsa012300.61680047
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61408996
117beta-Alanine metabolism_Homo sapiens_hsa004100.58748974
118Circadian rhythm_Homo sapiens_hsa047100.55620812
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.53305099
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53217581
121Ribosome_Homo sapiens_hsa030100.52993439
122Ovarian steroidogenesis_Homo sapiens_hsa049130.51735857
123Calcium signaling pathway_Homo sapiens_hsa040200.51597348
124Steroid biosynthesis_Homo sapiens_hsa001000.51038110
125Endocytosis_Homo sapiens_hsa041440.50690111
126Legionellosis_Homo sapiens_hsa051340.50239772
127VEGF signaling pathway_Homo sapiens_hsa043700.48005544
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.47153339
129Synaptic vesicle cycle_Homo sapiens_hsa047210.45982448
130Primary immunodeficiency_Homo sapiens_hsa053400.45752264
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44432374
132Serotonergic synapse_Homo sapiens_hsa047260.44424597
133Mismatch repair_Homo sapiens_hsa034300.44332981
134Renin-angiotensin system_Homo sapiens_hsa046140.42337106
135Pancreatic secretion_Homo sapiens_hsa049720.41439461
136Salivary secretion_Homo sapiens_hsa049700.40961589
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40839520
138Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39815929
139Cocaine addiction_Homo sapiens_hsa050300.39183897
140Circadian entrainment_Homo sapiens_hsa047130.38599226
141Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38408299
142Fatty acid elongation_Homo sapiens_hsa000620.37604669
143Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35670166
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35375192
145cAMP signaling pathway_Homo sapiens_hsa040240.34270602
146Inositol phosphate metabolism_Homo sapiens_hsa005620.33080599
147Gastric acid secretion_Homo sapiens_hsa049710.32694541
148Drug metabolism - other enzymes_Homo sapiens_hsa009830.31938916
149p53 signaling pathway_Homo sapiens_hsa041150.31320234
150Protein digestion and absorption_Homo sapiens_hsa049740.31264954
151Metabolic pathways_Homo sapiens_hsa011000.28859269
152Taste transduction_Homo sapiens_hsa047420.28620913
153Viral carcinogenesis_Homo sapiens_hsa052030.27936000
154Type II diabetes mellitus_Homo sapiens_hsa049300.25924395
155Insulin resistance_Homo sapiens_hsa049310.22626148
156Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21632354
157Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21611895
158B cell receptor signaling pathway_Homo sapiens_hsa046620.20907147
159Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19133524
160Salmonella infection_Homo sapiens_hsa051320.18236077
161Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17687268
162HIF-1 signaling pathway_Homo sapiens_hsa040660.16868390
163N-Glycan biosynthesis_Homo sapiens_hsa005100.15920713
164Aldosterone synthesis and secretion_Homo sapiens_hsa049250.15655251

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