ATP8B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the P-type cation transport ATPase family, which belongs to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Mutations in this gene may result in progressive familial intrahepatic cholestasis type 1 and in benign recurrent intrahepatic cholestasis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)6.67487875
2intestinal absorption (GO:0050892)6.43623767
3Golgi transport vesicle coating (GO:0048200)6.11238710
4COPI coating of Golgi vesicle (GO:0048205)6.11238710
5UDP-N-acetylglucosamine metabolic process (GO:0006047)5.29948101
6endocrine pancreas development (GO:0031018)5.03278304
7COPII vesicle coating (GO:0048208)4.96326439
8desmosome organization (GO:0002934)4.74520404
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.53225789
10peptide hormone processing (GO:0016486)4.44111950
11regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.40360693
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.38775038
13L-phenylalanine catabolic process (GO:0006559)4.38775038
14sequestering of extracellular ligand from receptor (GO:0035581)4.30438177
15regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.21938257
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.19287430
17L-phenylalanine metabolic process (GO:0006558)4.19287430
18protein retention in ER lumen (GO:0006621)3.98704618
19cell adhesion mediated by integrin (GO:0033627)3.96008187
20glandular epithelial cell differentiation (GO:0002067)3.91096957
21glucuronate metabolic process (GO:0019585)3.89378593
22uronic acid metabolic process (GO:0006063)3.89378593
23regulation of bile acid biosynthetic process (GO:0070857)3.87838243
24purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.87712491
253-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.87712491
26intestinal epithelial cell development (GO:0060576)3.85247957
27transcytosis (GO:0045056)3.83249541
28sulfur amino acid catabolic process (GO:0000098)3.80500031
29actin filament depolymerization (GO:0030042)3.79746207
30retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.72155808
31triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.71137840
32endocardial cushion development (GO:0003197)3.70399772
33regulation of cholesterol homeostasis (GO:2000188)3.69693320
34homocysteine metabolic process (GO:0050667)3.68449160
35renal filtration (GO:0097205)3.64787292
36virion attachment to host cell (GO:0019062)3.63578431
37adhesion of symbiont to host cell (GO:0044650)3.63578431
38phospholipid efflux (GO:0033700)3.58835886
39skin morphogenesis (GO:0043589)3.57999917
40activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.56707008
41regulation of transforming growth factor beta1 production (GO:0032908)3.56617472
42angiotensin maturation (GO:0002003)3.54665594
43hormone catabolic process (GO:0042447)3.54072094
44exocrine pancreas development (GO:0031017)3.52248382
45sulfate transmembrane transport (GO:1902358)3.49755520
46* bile acid and bile salt transport (GO:0015721)3.47643628
47aromatic amino acid family catabolic process (GO:0009074)3.46181705
48renal system process involved in regulation of blood volume (GO:0001977)3.42873282
49lipoprotein metabolic process (GO:0042157)3.40667176
50high-density lipoprotein particle remodeling (GO:0034375)3.40319702
51drug catabolic process (GO:0042737)3.38593773
52glomerular filtration (GO:0003094)3.36775344
53signal peptide processing (GO:0006465)3.35830004
54positive regulation of nuclease activity (GO:0032075)3.35299709
55reverse cholesterol transport (GO:0043691)3.34524069
56chondrocyte proliferation (GO:0035988)3.33246059
57flavonoid metabolic process (GO:0009812)3.28097332
58collagen fibril organization (GO:0030199)3.24621161
59digestive system process (GO:0022600)3.23757862
60cellular response to hepatocyte growth factor stimulus (GO:0035729)3.23697711
61response to hepatocyte growth factor (GO:0035728)3.23697711
62positive regulation of fatty acid beta-oxidation (GO:0032000)3.23077441
63urea metabolic process (GO:0019627)3.22641971
64urea cycle (GO:0000050)3.22641971
65sequestering of metal ion (GO:0051238)3.20766710
66triglyceride homeostasis (GO:0070328)3.19109408
67acylglycerol homeostasis (GO:0055090)3.19109408
68cellular response to vitamin (GO:0071295)3.19097335
69cholesterol efflux (GO:0033344)3.18955655
70bundle of His cell to Purkinje myocyte communication (GO:0086069)3.18587346
71digestion (GO:0007586)3.16519580
72negative regulation of fatty acid transport (GO:2000192)3.15918621
73negative regulation of digestive system process (GO:0060457)3.15158646
74hypotonic response (GO:0006971)3.15136434
75O-glycan processing (GO:0016266)3.14948376
76regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.14385262
77L-alpha-amino acid transmembrane transport (GO:1902475)3.13335638
78vesicle coating (GO:0006901)3.12511028
79regulation of triglyceride catabolic process (GO:0010896)3.12378758
80cysteine metabolic process (GO:0006534)3.10581821
81columnar/cuboidal epithelial cell development (GO:0002066)3.09511073
82regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.09502201
83hemidesmosome assembly (GO:0031581)3.09457419
84regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.08497608
85nucleotide-sugar biosynthetic process (GO:0009226)3.08496077
86plasma lipoprotein particle assembly (GO:0034377)3.08438631
87protein carboxylation (GO:0018214)3.08268912
88peptidyl-glutamic acid carboxylation (GO:0017187)3.08268912
89negative regulation of keratinocyte proliferation (GO:0010839)3.08164132
90endoplasmic reticulum unfolded protein response (GO:0030968)3.05850891
91epithelial cell-cell adhesion (GO:0090136)3.05566994
92endodermal cell differentiation (GO:0035987)3.04104257
93regulation of cholesterol esterification (GO:0010872)3.02503961
94regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.02382507
95positive regulation of glycolytic process (GO:0045821)3.02177090
96adhesion of symbiont to host (GO:0044406)3.02023022
97regulation of nuclease activity (GO:0032069)3.00459081
984-hydroxyproline metabolic process (GO:0019471)2.98966188
99cellular response to unfolded protein (GO:0034620)2.98254493
100sulfate transport (GO:0008272)2.97865409
101type B pancreatic cell development (GO:0003323)2.97203150
102protein-lipid complex remodeling (GO:0034368)2.96510914
103macromolecular complex remodeling (GO:0034367)2.96510914
104plasma lipoprotein particle remodeling (GO:0034369)2.96510914
105cholesterol homeostasis (GO:0042632)2.95979629
106sterol homeostasis (GO:0055092)2.95814106
107phospholipid homeostasis (GO:0055091)2.95513056
108cholesterol transport (GO:0030301)2.94975934
109sterol transport (GO:0015918)2.94975934
110nitrogen cycle metabolic process (GO:0071941)2.93123454
111wound healing, spreading of epidermal cells (GO:0035313)2.92939104
112sphingomyelin metabolic process (GO:0006684)2.91105335
113epoxygenase P450 pathway (GO:0019373)2.90685609
114ER-nucleus signaling pathway (GO:0006984)2.89943246
115negative regulation of cholesterol transport (GO:0032375)2.88203100
116negative regulation of sterol transport (GO:0032372)2.88203100
117alpha-linolenic acid metabolic process (GO:0036109)2.86714659
118calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.86353887
119protein-lipid complex assembly (GO:0065005)2.83358466
120extracellular matrix assembly (GO:0085029)2.83200510
121cellular response to vitamin D (GO:0071305)2.82878733
122type B pancreatic cell proliferation (GO:0044342)2.82595821
123macroautophagy (GO:0016236)2.82223773
124regulation of protein activation cascade (GO:2000257)2.80337053
125cellular response to topologically incorrect protein (GO:0035967)2.79745886
126nucleotide-sugar metabolic process (GO:0009225)2.79708617
127protein maturation by protein folding (GO:0022417)2.78316183
128cellular glucuronidation (GO:0052695)2.77620585
129bile acid biosynthetic process (GO:0006699)2.77074127
130tryptophan metabolic process (GO:0006568)2.76164516
131ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.76032312
132regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.75539316
133blood vessel maturation (GO:0001955)2.74240641
134fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.73506936
135* bile acid metabolic process (GO:0008206)2.73315978
136regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.73122202
137endocrine process (GO:0050886)2.73122202
138regulation of systemic arterial blood pressure by hormone (GO:0001990)2.73122202
139complement activation, alternative pathway (GO:0006957)2.72225444
140oligosaccharide biosynthetic process (GO:0009312)2.72017210
141extracellular regulation of signal transduction (GO:1900115)2.71921715
142extracellular negative regulation of signal transduction (GO:1900116)2.71921715
143protein autoprocessing (GO:0016540)2.71011205
144maintenance of gastrointestinal epithelium (GO:0030277)2.70073469
145positive regulation of fatty acid biosynthetic process (GO:0045723)2.68910194
146negative regulation of leukocyte chemotaxis (GO:0002689)2.65644892
147gap junction assembly (GO:0016264)2.64428911
148lymphangiogenesis (GO:0001946)2.63455091
149cell-substrate junction assembly (GO:0007044)2.62460170
150vascular endothelial growth factor signaling pathway (GO:0038084)2.60217668
151smooth muscle tissue development (GO:0048745)2.57279242
152negative regulation of anoikis (GO:2000811)2.56861512
153positive regulation of endothelial cell apoptotic process (GO:2000353)2.56314333
154regulation of apoptotic process involved in morphogenesis (GO:1902337)2.55792821
155protein localization to endosome (GO:0036010)2.54469624
156protein heterotrimerization (GO:0070208)2.52430118
157regulation of metalloenzyme activity (GO:0048552)2.51993926
158tight junction assembly (GO:0070830)2.51559832
159ethanol oxidation (GO:0006069)2.51289619
160ethanol metabolic process (GO:0006067)2.51094379
161positive regulation of pseudopodium assembly (GO:0031274)2.47976007
162branching involved in mammary gland duct morphogenesis (GO:0060444)2.47934652
163bone trabecula formation (GO:0060346)2.47046769
164regulation of fatty acid beta-oxidation (GO:0031998)2.46732881
165regulation of systemic arterial blood pressure (GO:0003073)2.46262416
166membrane protein ectodomain proteolysis (GO:0006509)2.45387620
167renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.44592200
168regulation of extracellular matrix disassembly (GO:0010715)2.44433788
169regulation of plasminogen activation (GO:0010755)2.43759094
170retina vasculature morphogenesis in camera-type eye (GO:0061299)2.43693330
171positive regulation of fatty acid oxidation (GO:0046321)2.43605743
172regulation of guanylate cyclase activity (GO:0031282)2.42948634
173barbed-end actin filament capping (GO:0051016)2.42813553
174wound healing, spreading of cells (GO:0044319)2.41812825
175positive regulation of blood vessel endothelial cell migration (GO:0043536)2.41762160
176basement membrane organization (GO:0071711)2.40227303
177regulation of integrin-mediated signaling pathway (GO:2001044)2.40149394
178primary alcohol catabolic process (GO:0034310)2.39893491
179multicellular organismal water homeostasis (GO:0050891)2.39458916
180negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.38262157
181multicellular organismal metabolic process (GO:0044236)2.37859196

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.55486594
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.04055591
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.52015801
4* LXR_22158963_ChIP-Seq_LIVER_Mouse4.50147944
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.30487782
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.49948379
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.49093695
8GATA1_22025678_ChIP-Seq_K562_Human3.25817664
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.16349991
10* SOX2_27498859_Chip-Seq_STOMACH_Mouse3.11550094
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.98658727
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.69242088
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.64588880
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.49288837
15GATA4_25053715_ChIP-Seq_YYC3_Human2.23809231
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.10798631
17* CDX2_20551321_ChIP-Seq_CACO-2_Human2.07058562
18SOX2_20726797_ChIP-Seq_SW620_Human2.01227001
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.97065360
20CLOCK_20551151_ChIP-Seq_293T_Human1.92692931
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.92338777
22* FOXA2_19822575_ChIP-Seq_HepG2_Human1.85861460
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.85627158
24BRD4_25478319_ChIP-Seq_HGPS_Human1.81267033
25* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.76434583
26* GATA6_25053715_ChIP-Seq_YYC3_Human1.71968634
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.71269293
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.70524096
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68734583
30AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.67443622
31FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.63839283
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58717483
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.58007854
34* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.56202441
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.55904238
36* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.55627799
37* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.53261485
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.50753197
39FOXA1_25552417_ChIP-Seq_VCAP_Human1.45601947
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44749134
41PPAR_26484153_Chip-Seq_NCI-H1993_Human1.43203507
42AR_21909140_ChIP-Seq_LNCAP_Human1.41817674
43TP53_16413492_ChIP-PET_HCT116_Human1.40109584
44ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36538997
45TP53_18474530_ChIP-ChIP_U2OS_Human1.34621673
46* HNF4A_19822575_ChIP-Seq_HepG2_Human1.34511423
47* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.34302640
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29605363
49* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28527691
50CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27910728
51* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26771957
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.24699740
53SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21334383
54JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20509395
55TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19489834
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.18678197
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18256951
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16413993
59TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.15808922
60FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15319328
61* GATA3_24758297_ChIP-Seq_MCF-7_Human1.13213006
62BCAT_22108803_ChIP-Seq_LS180_Human1.09265300
63* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.06765179
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.05706844
65FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.04014458
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03393496
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02465571
68NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02465571
69ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02385505
70FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00327522
71TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99707791
72CDX2_22108803_ChIP-Seq_LS180_Human0.99644706
73ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98147957
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97368019
75STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97219792
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97091410
77PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96465610
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96360567
79SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96256529
80P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96053741
81GATA1_19941826_ChIP-Seq_K562_Human0.95866746
82* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95270307
83KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94393410
84HTT_18923047_ChIP-ChIP_STHdh_Human0.94060726
85TP63_23658742_ChIP-Seq_EP156T_Human0.93485556
86RUNX1_27514584_Chip-Seq_MCF-7_Human0.92930308
87ZNF263_19887448_ChIP-Seq_K562_Human0.92147317
88WT1_19549856_ChIP-ChIP_CCG9911_Human0.91413373
89* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91093850
90NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91069754
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89167588
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87601200
93SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86844662
94CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85949655
95NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84676076
96RXR_22108803_ChIP-Seq_LS180_Human0.84628050
97ATF3_27146783_Chip-Seq_COLON_Human0.84589335
98NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84565763
99TP53_22127205_ChIP-Seq_IMR90_Human0.83934329
100EP300_21415370_ChIP-Seq_HL-1_Mouse0.82968801
101UBF1/2_26484160_Chip-Seq_HMECs_Human0.82935626
102AHR_22903824_ChIP-Seq_MCF-7_Human0.82144446
103GATA2_19941826_ChIP-Seq_K562_Human0.81929876
104PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80643386
105CJUN_26792858_Chip-Seq_BT549_Human0.80134128
106ELK3_25401928_ChIP-Seq_HUVEC_Human0.79315452
107GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.77381449
108RARG_19884340_ChIP-ChIP_MEFs_Mouse0.74669485
109CTNNB1_20460455_ChIP-Seq_HCT116_Human0.73232872
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.71834746
111CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.70420605
112ERG_20517297_ChIP-Seq_VCAP_Human0.69940104
113RACK7_27058665_Chip-Seq_MCF-7_Human0.69635394
114* TBX20_22328084_ChIP-Seq_HEART_Mouse0.69037531
115* TBX20_22080862_ChIP-Seq_HEART_Mouse0.69037531
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68672519
117TCF4_18268006_ChIP-ChIP_LS174T_Human0.68527777
118RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.67123845
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.66725468
120CREB1_26743006_Chip-Seq_LNCaP_Human0.65545528
121KLF5_25053715_ChIP-Seq_YYC3_Human0.65188068
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.64984929
123* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.64504854
124ARNT_22903824_ChIP-Seq_MCF-7_Human0.63512781
125JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.62049338
126SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.61916385
127SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.61916385

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.36761103
2MP0002139_abnormal_hepatobiliary_system5.17392937
3MP0008438_abnormal_cutaneous_collagen5.00641117
4MP0001666_abnormal_nutrient_absorption4.30853315
5* MP0005085_abnormal_gallbladder_physiolo3.93985268
6* MP0005365_abnormal_bile_salt3.91243099
7MP0005275_abnormal_skin_tensile3.15531546
8MP0008875_abnormal_xenobiotic_pharmacok3.03328217
9MP0004264_abnormal_extraembryonic_tissu2.97649216
10MP0003195_calcinosis2.95706823
11MP0002877_abnormal_melanocyte_morpholog2.89798349
12MP0005503_abnormal_tendon_morphology2.82181246
13MP0004043_abnormal_pH_regulation2.80347863
14MP0003283_abnormal_digestive_organ2.76920442
15MP0004272_abnormal_basement_membrane2.74741992
16* MP0003252_abnormal_bile_duct2.71761054
17MP0001958_emphysema2.67283898
18MP0003868_abnormal_feces_composition2.62317702
19MP0003279_aneurysm2.61496161
20MP0003566_abnormal_cell_adhesion2.55451577
21MP0010234_abnormal_vibrissa_follicle2.54606548
22MP0009780_abnormal_chondrocyte_physiolo2.53780309
23MP0010329_abnormal_lipoprotein_level2.35617023
24MP0002693_abnormal_pancreas_physiology2.35096995
25MP0005257_abnormal_intraocular_pressure2.33642914
26MP0000462_abnormal_digestive_system2.33113529
27MP0003950_abnormal_plasma_membrane2.31970342
28MP0003941_abnormal_skin_development2.25564991
29MP0003300_gastrointestinal_ulcer2.22094504
30MP0003806_abnormal_nucleotide_metabolis2.20895731
31MP0005220_abnormal_exocrine_pancreas2.18981581
32MP0001944_abnormal_pancreas_morphology2.14086019
33MP0009840_abnormal_foam_cell2.10181647
34MP0003183_abnormal_peptide_metabolism2.04454500
35MP0005083_abnormal_biliary_tract2.02539917
36MP0005023_abnormal_wound_healing2.00975682
37MP0010386_abnormal_urinary_bladder1.91566281
38MP0002909_abnormal_adrenal_gland1.90249563
39MP0006054_spinal_hemorrhage1.88333912
40MP0000013_abnormal_adipose_tissue1.85284344
41MP0009643_abnormal_urine_homeostasis1.77152631
42MP0000678_abnormal_parathyroid_gland1.73104975
43MP0002138_abnormal_hepatobiliary_system1.72083366
44MP0005623_abnormal_meninges_morphology1.69979963
45MP0003091_abnormal_cell_migration1.68405910
46MP0005332_abnormal_amino_acid1.65908198
47MP0002078_abnormal_glucose_homeostasis1.62428476
48MP0002118_abnormal_lipid_homeostasis1.59482358
49MP0004019_abnormal_vitamin_homeostasis1.58518333
50MP0005379_endocrine/exocrine_gland_phen1.57503519
51MP0005409_darkened_coat_color1.52929160
52MP0001542_abnormal_bone_strength1.50710559
53MP0003866_abnormal_defecation1.42909173
54* MP0000609_abnormal_liver_physiology1.42143650
55MP0000767_abnormal_smooth_muscle1.40740859
56MP0001765_abnormal_ion_homeostasis1.40456769
57MP0005084_abnormal_gallbladder_morpholo1.32597394
58MP0000538_abnormal_urinary_bladder1.31063448
59MP0005636_abnormal_mineral_homeostasis1.29977954
60MP0000613_abnormal_salivary_gland1.29773791
61MP0004782_abnormal_surfactant_physiolog1.28904659
62MP0001664_abnormal_digestion1.27647064
63MP0003191_abnormal_cellular_cholesterol1.25739271
64MP0000534_abnormal_ureter_morphology1.21086153
65MP0004858_abnormal_nervous_system1.20982472
66MP0002896_abnormal_bone_mineralization1.20533842
67MP0003705_abnormal_hypodermis_morpholog1.18066261
68MP0001756_abnormal_urination1.17735936
69MP0005501_abnormal_skin_physiology1.16200494
70MP0005595_abnormal_vascular_smooth1.15200495
71MP0000003_abnormal_adipose_tissue1.14935536
72MP0008004_abnormal_stomach_pH1.08901344
73MP0002837_dystrophic_cardiac_calcinosis1.08442348
74MP0001879_abnormal_lymphatic_vessel1.07169367
75MP0005448_abnormal_energy_balance1.07159637
76MP0001243_abnormal_dermal_layer1.07146286
77MP0002168_other_aberrant_phenotype1.05568832
78MP0005408_hypopigmentation1.03402628
79MP0005508_abnormal_skeleton_morphology1.03336402
80MP0003953_abnormal_hormone_level1.03019013
81MP0002876_abnormal_thyroid_physiology1.02909746
82MP0005165_increased_susceptibility_to1.00908677
83MP0000762_abnormal_tongue_morphology0.98910771
84MP0005381_digestive/alimentary_phenotyp0.98707241
85MP0002928_abnormal_bile_duct0.98649113
86MP0002254_reproductive_system_inflammat0.92069554
87MP0001764_abnormal_homeostasis0.91570551
88* MP0005319_abnormal_enzyme/_coenzyme0.88716224
89MP0004134_abnormal_chest_morphology0.83625185
90MP0002060_abnormal_skin_morphology0.83121553
91MP0000427_abnormal_hair_cycle0.82488606
92MP0001216_abnormal_epidermal_layer0.82187553
93* MP0009642_abnormal_blood_homeostasis0.80753993
94MP0001849_ear_inflammation0.79995326
95MP0005164_abnormal_response_to0.79693971
96MP0009379_abnormal_foot_pigmentation0.79253515
97MP0002166_altered_tumor_susceptibility0.79120642
98MP0000230_abnormal_systemic_arterial0.78712709
99MP0010155_abnormal_intestine_physiology0.78675949
100MP0002108_abnormal_muscle_morphology0.78138569
101MP0000627_abnormal_mammary_gland0.77962047
102MP0009384_cardiac_valve_regurgitation0.77580401
103MP0001661_extended_life_span0.77392970
104MP0002295_abnormal_pulmonary_circulatio0.77356824
105MP0000477_abnormal_intestine_morphology0.76613668
106MP0002234_abnormal_pharynx_morphology0.75283468
107MP0000537_abnormal_urethra_morphology0.72186623
108MP0005670_abnormal_white_adipose0.72154267
109MP0000470_abnormal_stomach_morphology0.72085449
110MP0003045_fibrosis0.72027165
111MP0008961_abnormal_basal_metabolism0.71813576
112MP0000490_abnormal_crypts_of0.71396739
113MP0001663_abnormal_digestive_system0.70482247
114MP0010368_abnormal_lymphatic_system0.70323974
115MP0005375_adipose_tissue_phenotype0.68649096
116MP0005334_abnormal_fat_pad0.68520361
117MP0010771_integument_phenotype0.68244287
118MP0000163_abnormal_cartilage_morphology0.68117427
119MP0001881_abnormal_mammary_gland0.67998784
120MP0005166_decreased_susceptibility_to0.67344850
121MP0000465_gastrointestinal_hemorrhage0.66787407
122MP0005058_abnormal_lysosome_morphology0.65855359
123MP0005187_abnormal_penis_morphology0.65542550
124MP0000733_abnormal_muscle_development0.64955047
125MP0002009_preneoplasia0.64832257
126MP0002098_abnormal_vibrissa_morphology0.64281192
127MP0009053_abnormal_anal_canal0.64028258
128MP0005535_abnormal_body_temperature0.62873395
129MP0000579_abnormal_nail_morphology0.62145343
130MP0003959_abnormal_lean_body0.61902091
131MP0001873_stomach_inflammation0.60612255
132MP0005310_abnormal_salivary_gland0.60206970
133* MP0000598_abnormal_liver_morphology0.59166459
134MP0005584_abnormal_enzyme/coenzyme_acti0.58799429
135MP0002796_impaired_skin_barrier0.57278319
136MP0005248_abnormal_Harderian_gland0.57125887
137MP0004185_abnormal_adipocyte_glucose0.57085878
138MP0010352_gastrointestinal_tract_polyps0.54697278
139MP0005367_renal/urinary_system_phenotyp0.54243856
140MP0000516_abnormal_urinary_system0.54243856
141MP0002136_abnormal_kidney_physiology0.53338357
142MP0005167_abnormal_blood-brain_barrier0.53159456
143MP0003119_abnormal_digestive_system0.52967071
144MP0005666_abnormal_adipose_tissue0.52844031
145MP0010678_abnormal_skin_adnexa0.52770069
146MP0000467_abnormal_esophagus_morphology0.52724291
147MP0009697_abnormal_copulation0.51293971

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)6.13936895
2Hypoglycemic coma (HP:0001325)6.09364508
3Hypoglycemic seizures (HP:0002173)5.99197384
4Premature rupture of membranes (HP:0001788)5.61080865
5Symptomatic seizures (HP:0011145)5.46851725
6Protrusio acetabuli (HP:0003179)5.24098117
7Abnormality of aromatic amino acid family metabolism (HP:0004338)4.66707596
8Aortic dissection (HP:0002647)4.64691938
9Aortic aneurysm (HP:0004942)4.58973453
10Hyperglycemia (HP:0003074)4.53337875
11Ketoacidosis (HP:0001993)4.38782441
12Neonatal short-limb short stature (HP:0008921)4.23378362
13Flat acetabular roof (HP:0003180)4.20603066
14Abnormality of the intrinsic pathway (HP:0010989)4.20451263
15Hypobetalipoproteinemia (HP:0003563)4.20092687
16Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.13066971
17Vascular tortuosity (HP:0004948)3.95591866
18Late onset (HP:0003584)3.94208762
19Xanthomatosis (HP:0000991)3.93538611
20Abnormality of the pancreatic islet cells (HP:0006476)3.86498819
21Abnormality of endocrine pancreas physiology (HP:0012093)3.86498819
22Abnormality of the common coagulation pathway (HP:0010990)3.81231038
23Arterial tortuosity (HP:0005116)3.80146286
24Ileus (HP:0002595)3.76159145
25Insulin-resistant diabetes mellitus (HP:0000831)3.75082472
26* Intrahepatic cholestasis (HP:0001406)3.60944605
27Pancreatic islet-cell hyperplasia (HP:0004510)3.52207926
28Ketosis (HP:0001946)3.48059163
29Abnormality of glutamine family amino acid metabolism (HP:0010902)3.46611678
30Broad metatarsal (HP:0001783)3.42105059
31Prolonged partial thromboplastin time (HP:0003645)3.40275424
32Cardiovascular calcification (HP:0011915)3.37751538
33Deep venous thrombosis (HP:0002625)3.35203444
34Cervical subluxation (HP:0003308)3.33399217
35* Fat malabsorption (HP:0002630)3.30879184
36Abdominal distention (HP:0003270)3.28938699
37Ankle contracture (HP:0006466)3.18895408
38Right ventricular cardiomyopathy (HP:0011663)3.15913832
39Hypolipoproteinemia (HP:0010981)3.12472930
40Osteolytic defects of the phalanges of the hand (HP:0009771)3.07280566
41Osteolytic defects of the hand bones (HP:0009699)3.07280566
42Atrophic scars (HP:0001075)3.06628375
43Acanthocytosis (HP:0001927)3.02793549
44* Abnormality of monocarboxylic acid metabolism (HP:0010996)3.01497731
45Epidermoid cyst (HP:0200040)2.95118699
46Generalized aminoaciduria (HP:0002909)2.92969911
47Follicular hyperkeratosis (HP:0007502)2.90184053
48Wormian bones (HP:0002645)2.89142027
49Urinary glycosaminoglycan excretion (HP:0003541)2.85930707
50Mucopolysacchariduria (HP:0008155)2.85930707
51Skin nodule (HP:0200036)2.85283955
52Fragile skin (HP:0001030)2.83932037
53Abnormality of purine metabolism (HP:0004352)2.83079273
54Insulin resistance (HP:0000855)2.82289610
55Thin bony cortex (HP:0002753)2.82259488
56Soft skin (HP:0000977)2.81904305
57Abnormal pancreas size (HP:0012094)2.77987935
58Aortic regurgitation (HP:0001659)2.77569996
59Mildly elevated creatine phosphokinase (HP:0008180)2.75116182
60Abnormality of the acetabulum (HP:0003170)2.73223164
61Vascular calcification (HP:0004934)2.71902789
62Large for gestational age (HP:0001520)2.69431069
63Spinal cord compression (HP:0002176)2.69300978
64Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.68494856
65Decreased circulating renin level (HP:0003351)2.65681535
66Abnormality of carpal bone ossification (HP:0006257)2.61822069
67Spondylolisthesis (HP:0003302)2.61096645
68Abnormality of mucopolysaccharide metabolism (HP:0011020)2.60489845
69Abnormality of polysaccharide metabolism (HP:0011012)2.60489845
70Abnormality of glycosaminoglycan metabolism (HP:0004371)2.60489845
71Malnutrition (HP:0004395)2.57783662
72Complement deficiency (HP:0004431)2.56670774
73Hyperactive renin-angiotensin system (HP:0000841)2.54069155
74Blue sclerae (HP:0000592)2.53174538
75Bladder diverticulum (HP:0000015)2.49081530
76Short nail (HP:0001799)2.48898450
77Abnormality of the distal phalanx of the thumb (HP:0009617)2.48739067
78Abnormality of sulfur amino acid metabolism (HP:0004339)2.47550167
79Metabolic alkalosis (HP:0200114)2.47272651
80Abnormality of calcium-phosphate metabolism (HP:0100530)2.45168925
81Spinal rigidity (HP:0003306)2.44685183
82Aneurysm (HP:0002617)2.43554309
83Protuberant abdomen (HP:0001538)2.42313636
84Hyperglycinuria (HP:0003108)2.41123542
85Hyperammonemia (HP:0001987)2.40567508
86Hypoalphalipoproteinemia (HP:0003233)2.40350146
87Genu recurvatum (HP:0002816)2.37488439
88Steatorrhea (HP:0002570)2.37444238
89Shallow orbits (HP:0000586)2.34920656
90Abnormality of chloride homeostasis (HP:0011422)2.33553670
91Dilatation of the ascending aorta (HP:0005111)2.33412635
92Hydroxyprolinuria (HP:0003080)2.31735596
93Abnormality of proline metabolism (HP:0010907)2.31735596
94Hypokalemia (HP:0002900)2.31174539
95Abnormality of urine glucose concentration (HP:0011016)2.31169809
96Glycosuria (HP:0003076)2.31169809
97Abnormal ossification of hand bones (HP:0005921)2.30645606
98Abnormality of dentin (HP:0010299)2.29480651
99Exocrine pancreatic insufficiency (HP:0001738)2.28364160
100Mitral stenosis (HP:0001718)2.25175869
101Overgrowth (HP:0001548)2.20588798
102Breech presentation (HP:0001623)2.17905150
103Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.17864933
104Flat capital femoral epiphysis (HP:0003370)2.17315038
105Hypophosphatemia (HP:0002148)2.16596929
106Dysostosis multiplex (HP:0000943)2.16316537
107Abnormality of aspartate family amino acid metabolism (HP:0010899)2.15995323
108Gout (HP:0001997)2.14956215
109Mitral valve prolapse (HP:0001634)2.14038212
110Abnormality of nucleobase metabolism (HP:0010932)2.13761923
111Abnormal hand bone ossification (HP:0010660)2.13622043
112Hyperlipoproteinemia (HP:0010980)2.12791703
113Congenital sensorineural hearing impairment (HP:0008527)2.12295852
114Abnormality of renin-angiotensin system (HP:0000847)2.11689131
115Abnormal delivery (HP:0001787)2.11283627
116Type 1 muscle fiber predominance (HP:0003803)2.11065762
117Hyperparathyroidism (HP:0000843)2.10995364
118Hyperextensible skin (HP:0000974)2.10894825
119Hyperaldosteronism (HP:0000859)2.10311838
120Villous atrophy (HP:0011473)2.09435641
121Abnormality of small intestinal villus morphology (HP:0011472)2.09435641
122Abnormality of the distal phalanges of the toes (HP:0010182)2.09233460
123Hyperglycinemia (HP:0002154)2.07810762
124Vertebral compression fractures (HP:0002953)2.07383847
125Osteoarthritis (HP:0002758)2.06351904
126Renal tubular acidosis (HP:0001947)2.05350514
127* Conjugated hyperbilirubinemia (HP:0002908)2.04375169
128Widely patent fontanelles and sutures (HP:0004492)2.04042776
129Peritonitis (HP:0002586)2.03813672
130Abnormal tarsal ossification (HP:0008369)2.03336503
131Ovoid vertebral bodies (HP:0003300)2.01806265
132Abnormality of serine family amino acid metabolism (HP:0010894)1.99993335
133Abnormality of glycine metabolism (HP:0010895)1.99993335
134Abnormal enzyme/coenzyme activity (HP:0012379)1.98822628
135Metabolic acidosis (HP:0001942)1.98213640
136Tibial bowing (HP:0002982)1.97959027
137Hyperphosphaturia (HP:0003109)1.97814461
138Elevated alkaline phosphatase (HP:0003155)1.97763915
139Hypercholesterolemia (HP:0003124)1.97326772
140Abnormality of potassium homeostasis (HP:0011042)1.95467122
141Focal segmental glomerulosclerosis (HP:0000097)1.95445666
142Hemorrhage of the eye (HP:0011885)1.95426697
143Joint laxity (HP:0001388)1.95155379
144Alkalosis (HP:0001948)1.94579939
145Abnormality of alkaline phosphatase activity (HP:0004379)1.94375883
146Flattened epiphyses (HP:0003071)1.93354865
147Limb hypertonia (HP:0002509)1.93112315
148Distal upper limb amyotrophy (HP:0007149)1.92960817
149Upper limb amyotrophy (HP:0009129)1.92960817
150Joint hemorrhage (HP:0005261)1.91676414
151Abnormality of vitamin metabolism (HP:0100508)1.89521196
152Irritability (HP:0000737)1.88764536
153Retinal atrophy (HP:0001105)1.87752175
154Abnormality of fatty-acid metabolism (HP:0004359)1.87425871
155Hoarse voice (HP:0001609)1.86358548
156Aortic valve stenosis (HP:0001650)1.85960144
157Chronic diarrhea (HP:0002028)1.85569652
158Abnormal foot bone ossification (HP:0010675)1.84553080
159Broad face (HP:0000283)1.83929290
160Osteomalacia (HP:0002749)1.83586615
161* Hyperbilirubinemia (HP:0002904)1.82255034
162Cerebral aneurysm (HP:0004944)1.81277791
163Chondrocalcinosis (HP:0000934)1.81009368
164Elbow flexion contracture (HP:0002987)1.80582167
165Abnormality of complement system (HP:0005339)1.79789137
166Absent frontal sinuses (HP:0002688)1.79322784
167Abnormal cartilage morphology (HP:0002763)1.79230136
168Nephrolithiasis (HP:0000787)1.78895948
169Esophageal varix (HP:0002040)1.78589501
170Long toe (HP:0010511)1.78120862
171Coxa vara (HP:0002812)1.76724252
172Femoral bowing (HP:0002980)1.75616485
173Hip contracture (HP:0003273)1.74954582
174Abnormality of Sharpey fibers (HP:0100685)1.74793114
175Mitral regurgitation (HP:0001653)1.73982919
176Abnormal vertebral ossification (HP:0100569)1.72141194
177Natal tooth (HP:0000695)1.71319001
178Hyperkalemia (HP:0002153)1.70519618
179Hyperphosphatemia (HP:0002905)1.69901785
180Abnormality of the phalanges of the hallux (HP:0010057)1.69846816
181Distal lower limb amyotrophy (HP:0008944)1.69741657
182Hemangiomatosis (HP:0007461)1.68493262
183Abnormal glucose tolerance (HP:0001952)1.66079465
184Visceral angiomatosis (HP:0100761)1.65535906

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.67589445
2INSRR5.42212868
3TAOK35.04318929
4ERN12.88174661
5MAPK152.70535560
6MAP3K22.67315205
7PASK2.59838428
8ACVR1B2.49316972
9LMTK22.28240407
10MST1R2.26742057
11LATS12.09449443
12PTK62.02830763
13AKT31.88576426
14PDGFRA1.82070910
15MAP2K21.78686359
16MET1.74448777
17IRAK31.71780054
18NUAK11.67952052
19MAP3K121.65560894
20BCKDK1.65509619
21TTN1.65480596
22TRPM71.59413132
23HIPK21.58533633
24WNK41.56154147
25PRKD31.56083175
26SIK11.53325665
27MAPKAPK31.50473471
28MAP3K11.45960863
29FLT31.44986559
30EPHA21.40120795
31SCYL21.39892926
32FGFR41.39578097
33PIK3CG1.39157905
34RIPK11.38446172
35MST41.37262369
36PRKG21.36988908
37PTK21.35312442
38PAK41.35104580
39STK381.22922373
40EPHA31.20586202
41ERBB41.18152253
42LIMK11.14684725
43STK38L1.10464101
44CDC42BPA1.08398837
45FER1.08032574
46STK241.01285126
47PIK3CA0.99988709
48DMPK0.92779438
49TRIB30.91361357
50OXSR10.90503118
51MAP3K30.87628972
52LATS20.85720598
53EPHB10.84706716
54PAK30.81352137
55NME10.80306728
56PRKAA10.78066934
57RPS6KA20.77271439
58MAP3K100.75325471
59PRKAA20.74591395
60JAK20.73816744
61STK390.72251181
62ABL20.72136549
63ROCK10.70956181
64NTRK10.70519209
65MYLK0.69357996
66WNK30.68693046
67DYRK1B0.68340004
68ERBB20.67988576
69JAK10.67305813
70GSK3A0.66993250
71IRAK10.66371493
72EEF2K0.65594779
73EIF2AK30.64977017
74PDGFRB0.64060448
75ICK0.63617010
76MAP2K10.62332925
77EPHB20.62083477
78PRKCH0.61951118
79PTK2B0.61198259
80FGFR20.60217786
81ILK0.59050678
82TIE10.57701811
83RET0.55654201
84TESK10.52432913
85PRKCI0.51046172
86FGFR30.50678477
87MAPK110.50661006
88CAMK2D0.49981081
89KDR0.49152185
90DDR20.48206605
91PDPK10.47475556
92PKN20.47244214
93ERBB30.45517253
94NEK90.45108428
95NLK0.44491938
96PRKACG0.44439034
97BRSK20.44363830
98PRKD10.42316942
99ADRBK10.42206378
100PRKCE0.41603211
101BMPR20.41264210
102NEK60.40260310
103ROCK20.39748186
104TESK20.39584276
105CAMKK20.39448245
106WNK10.38817248
107MAPKAPK20.38530110
108MELK0.38006844
109BMPR1B0.37324379
110MTOR0.37145386
111IGF1R0.36985177
112SMG10.36223319
113GRK10.34856559
114MAP3K70.34485781
115CDK120.34393691
116ITK0.33713127
117STK30.32488870
118SRC0.31900901
119IRAK20.31865080
120CAMK2G0.31397932
121PRKD20.31160738
122MAPK70.30810098
123CSNK1A10.30547833
124MAP3K60.29058112
125CSK0.28461474
126UHMK10.28374576
127PRKCA0.27949687
128CAMK2B0.26264989
129SGK30.23094048
130CHUK0.22884377
131TAOK10.22787305
132TGFBR20.22574135
133PAK20.21925834

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.15114289
2Sulfur metabolism_Homo sapiens_hsa009203.93932613
3Fat digestion and absorption_Homo sapiens_hsa049752.93945891
4Nitrogen metabolism_Homo sapiens_hsa009102.69860582
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.43599310
6Tryptophan metabolism_Homo sapiens_hsa003802.36309243
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.36304177
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.28345829
9Protein export_Homo sapiens_hsa030602.28279283
10ECM-receptor interaction_Homo sapiens_hsa045122.05174376
11Histidine metabolism_Homo sapiens_hsa003401.89436875
12Starch and sucrose metabolism_Homo sapiens_hsa005001.87421342
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82498246
14Fatty acid degradation_Homo sapiens_hsa000711.78939161
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.77681472
16Selenocompound metabolism_Homo sapiens_hsa004501.77213757
17Folate biosynthesis_Homo sapiens_hsa007901.72303500
18Bile secretion_Homo sapiens_hsa049761.67550414
19Arginine biosynthesis_Homo sapiens_hsa002201.64932235
20ABC transporters_Homo sapiens_hsa020101.63074994
21Caffeine metabolism_Homo sapiens_hsa002321.57575012
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.57004388
23Focal adhesion_Homo sapiens_hsa045101.56039372
24Butanoate metabolism_Homo sapiens_hsa006501.55868886
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.52758399
26Carbohydrate digestion and absorption_Homo sapiens_hsa049731.52108805
27Vitamin digestion and absorption_Homo sapiens_hsa049771.42450073
28Galactose metabolism_Homo sapiens_hsa000521.35774973
29Insulin secretion_Homo sapiens_hsa049111.33663068
30Tight junction_Homo sapiens_hsa045301.33620967
31Adherens junction_Homo sapiens_hsa045201.31670131
32Complement and coagulation cascades_Homo sapiens_hsa046101.30533718
33Renin-angiotensin system_Homo sapiens_hsa046141.25480041
34Protein digestion and absorption_Homo sapiens_hsa049741.24012017
35PPAR signaling pathway_Homo sapiens_hsa033201.23052801
36Mineral absorption_Homo sapiens_hsa049781.22884199
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.22263366
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21317668
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19752715
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.18158403
41Type II diabetes mellitus_Homo sapiens_hsa049301.14461074
42Pancreatic secretion_Homo sapiens_hsa049721.14395118
43Peroxisome_Homo sapiens_hsa041461.12711374
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.12650696
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12320269
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06001315
47Proteoglycans in cancer_Homo sapiens_hsa052051.05679110
48Amoebiasis_Homo sapiens_hsa051461.05425994
49Chemical carcinogenesis_Homo sapiens_hsa052041.04019206
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03096335
51Fatty acid metabolism_Homo sapiens_hsa012120.97973688
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97601588
53Propanoate metabolism_Homo sapiens_hsa006400.97591010
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97130329
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.95699386
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95598176
57Phenylalanine metabolism_Homo sapiens_hsa003600.94571935
58beta-Alanine metabolism_Homo sapiens_hsa004100.93692059
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.91927267
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91457887
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91124890
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86571651
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86546332
64N-Glycan biosynthesis_Homo sapiens_hsa005100.86158740
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84861427
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81439164
67Glycerolipid metabolism_Homo sapiens_hsa005610.81306375
68Retinol metabolism_Homo sapiens_hsa008300.80004998
69Fructose and mannose metabolism_Homo sapiens_hsa000510.77535698
70Thyroid hormone synthesis_Homo sapiens_hsa049180.77448380
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76099498
72Arginine and proline metabolism_Homo sapiens_hsa003300.75919794
73Insulin resistance_Homo sapiens_hsa049310.75721751
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75538961
75Lysine degradation_Homo sapiens_hsa003100.72440272
76Tyrosine metabolism_Homo sapiens_hsa003500.72217480
77Linoleic acid metabolism_Homo sapiens_hsa005910.71946094
78TGF-beta signaling pathway_Homo sapiens_hsa043500.71551924
79Small cell lung cancer_Homo sapiens_hsa052220.70763819
80Fatty acid elongation_Homo sapiens_hsa000620.63591966
81Vibrio cholerae infection_Homo sapiens_hsa051100.63197619
82Steroid biosynthesis_Homo sapiens_hsa001000.62650714
83Renin secretion_Homo sapiens_hsa049240.61855008
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61214579
85Pyruvate metabolism_Homo sapiens_hsa006200.60289214
86Hepatitis C_Homo sapiens_hsa051600.57629422
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57262179
88Glutathione metabolism_Homo sapiens_hsa004800.56370470
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.56324189
90Dilated cardiomyopathy_Homo sapiens_hsa054140.55952205
91Sphingolipid metabolism_Homo sapiens_hsa006000.53966434
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53858181
93Thyroid cancer_Homo sapiens_hsa052160.53181700
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51576548
95Hippo signaling pathway_Homo sapiens_hsa043900.49581757
96Fatty acid biosynthesis_Homo sapiens_hsa000610.49136327
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48655731
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47416331
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.43836292
100Type I diabetes mellitus_Homo sapiens_hsa049400.42248042
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41549335
102Other glycan degradation_Homo sapiens_hsa005110.40004793
103Prostate cancer_Homo sapiens_hsa052150.39827360
104Staphylococcus aureus infection_Homo sapiens_hsa051500.39732867
105Lysosome_Homo sapiens_hsa041420.38601544
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38414899
107Glucagon signaling pathway_Homo sapiens_hsa049220.38266853
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37778699
109Inositol phosphate metabolism_Homo sapiens_hsa005620.37361635
110Carbon metabolism_Homo sapiens_hsa012000.36253153
111Prion diseases_Homo sapiens_hsa050200.36060047
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34643001
113MicroRNAs in cancer_Homo sapiens_hsa052060.33665946
114Endocytosis_Homo sapiens_hsa041440.33367083
115TNF signaling pathway_Homo sapiens_hsa046680.32351562
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32269210
117Metabolic pathways_Homo sapiens_hsa011000.31653905
118Cocaine addiction_Homo sapiens_hsa050300.31066773
119Melanoma_Homo sapiens_hsa052180.30036623
120Pathways in cancer_Homo sapiens_hsa052000.29313968
121Choline metabolism in cancer_Homo sapiens_hsa052310.28784675
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28486468
123Platelet activation_Homo sapiens_hsa046110.27062842
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.26854201
125GnRH signaling pathway_Homo sapiens_hsa049120.26344500
126Bladder cancer_Homo sapiens_hsa052190.26220697
127Gap junction_Homo sapiens_hsa045400.24650348
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24640736
129Circadian rhythm_Homo sapiens_hsa047100.23812272
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.21505040
131Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.19745247
1322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.19708518
133AMPK signaling pathway_Homo sapiens_hsa041520.18762613
134Prolactin signaling pathway_Homo sapiens_hsa049170.16302403
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.15684259
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.15634424
137Arachidonic acid metabolism_Homo sapiens_hsa005900.15253010

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