ATP6V1G1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of three V1 domain G subunit proteins. Pseudogenes of this gene have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)6.61358945
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.26804595
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.18649395
4ATP synthesis coupled proton transport (GO:0015986)6.09943571
5energy coupled proton transport, down electrochemical gradient (GO:0015985)6.09943571
6respiratory electron transport chain (GO:0022904)5.21909602
7electron transport chain (GO:0022900)5.10672074
8axon ensheathment in central nervous system (GO:0032291)5.04534834
9central nervous system myelination (GO:0022010)5.04534834
10fatty acid elongation (GO:0030497)4.84142329
11chaperone-mediated protein transport (GO:0072321)4.68955173
12long-chain fatty acid biosynthetic process (GO:0042759)4.23404076
13water-soluble vitamin biosynthetic process (GO:0042364)4.19358942
14protein complex biogenesis (GO:0070271)3.97323817
15dopamine biosynthetic process (GO:0042416)3.96504742
16energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.86368658
17ATP hydrolysis coupled proton transport (GO:0015991)3.86368658
18hydrogen ion transmembrane transport (GO:1902600)3.73578095
19cholesterol biosynthetic process (GO:0006695)3.69006921
20platelet dense granule organization (GO:0060155)3.64123689
21mitochondrial respiratory chain complex I assembly (GO:0032981)3.61802215
22NADH dehydrogenase complex assembly (GO:0010257)3.61802215
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.61802215
24substantia nigra development (GO:0021762)3.56989787
25signal peptide processing (GO:0006465)3.44757813
26mitochondrial respiratory chain complex assembly (GO:0033108)3.43602555
27protein-cofactor linkage (GO:0018065)3.39777576
28nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.38166959
29regulation of mitochondrial translation (GO:0070129)3.37512267
30transcription elongation from RNA polymerase III promoter (GO:0006385)3.33968755
31termination of RNA polymerase III transcription (GO:0006386)3.33968755
32sterol biosynthetic process (GO:0016126)3.33829129
33exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.31272600
34neutrophil activation involved in immune response (GO:0002283)3.31194749
35* proton transport (GO:0015992)3.31191403
36cotranslational protein targeting to membrane (GO:0006613)3.30803733
37SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.29298024
38establishment of protein localization to mitochondrial membrane (GO:0090151)3.27412409
39* phagosome maturation (GO:0090382)3.25266138
40protein targeting to ER (GO:0045047)3.24705136
41* hydrogen transport (GO:0006818)3.22973813
42isoprenoid biosynthetic process (GO:0008299)3.22179141
43response to redox state (GO:0051775)3.18490605
44GTP biosynthetic process (GO:0006183)3.13955633
45establishment of protein localization to endoplasmic reticulum (GO:0072599)3.13607739
46proteasome assembly (GO:0043248)3.12373162
47protein localization to endoplasmic reticulum (GO:0070972)3.11645611
48positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.11506277
49DNA deamination (GO:0045006)3.07595480
50intracellular protein transmembrane import (GO:0044743)3.07301554
51tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.06689055
52RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.06689055
53amyloid precursor protein metabolic process (GO:0042982)3.04750735
54ribosomal small subunit assembly (GO:0000028)3.01405142
55protein localization to mitochondrion (GO:0070585)3.00919621
56establishment of protein localization to mitochondrion (GO:0072655)2.99462464
57regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.99316883
58negative regulation of neurotransmitter transport (GO:0051589)2.98579069
59peptidyl-histidine modification (GO:0018202)2.97584258
60epithelial cilium movement (GO:0003351)2.95463016
61regulation of hexokinase activity (GO:1903299)2.95262818
62regulation of glucokinase activity (GO:0033131)2.95262818
63cellular ketone body metabolic process (GO:0046950)2.95065608
64* transferrin transport (GO:0033572)2.93962861
65regulation of cilium movement (GO:0003352)2.93377279
66purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.92220917
67cullin deneddylation (GO:0010388)2.91708363
68DNA damage response, detection of DNA damage (GO:0042769)2.91066523
69ER overload response (GO:0006983)2.90391176
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.89449536
71preassembly of GPI anchor in ER membrane (GO:0016254)2.89379012
72dopamine transport (GO:0015872)2.88856128
73positive regulation of actin filament depolymerization (GO:0030836)2.88406980
74behavioral response to nicotine (GO:0035095)2.87091663
75intraciliary transport (GO:0042073)2.86499923
76ATP biosynthetic process (GO:0006754)2.86010998
77myelination (GO:0042552)2.84687859
78purine nucleoside triphosphate biosynthetic process (GO:0009145)2.84149720
79axon ensheathment (GO:0008366)2.84137117
80ensheathment of neurons (GO:0007272)2.84137117
81regulation of cellular amino acid metabolic process (GO:0006521)2.83606498
82GPI anchor metabolic process (GO:0006505)2.83046578
83signal transduction involved in cell cycle checkpoint (GO:0072395)2.82075390
84mannosylation (GO:0097502)2.81612226
85neuron cell-cell adhesion (GO:0007158)2.81259687
86translational termination (GO:0006415)2.80930897
87signal transduction involved in DNA integrity checkpoint (GO:0072401)2.80251380
88signal transduction involved in DNA damage checkpoint (GO:0072422)2.80251380
89anterograde synaptic vesicle transport (GO:0048490)2.80200800
90translation (GO:0006412)2.80181605
91viral transcription (GO:0019083)2.80154596
92catechol-containing compound biosynthetic process (GO:0009713)2.80090165
93catecholamine biosynthetic process (GO:0042423)2.80090165
94amyloid precursor protein catabolic process (GO:0042987)2.79852942
95C-terminal protein lipidation (GO:0006501)2.78950492
96antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.78151732
97regulation of collateral sprouting (GO:0048670)2.78056573
98regulation of dopamine metabolic process (GO:0042053)2.77723612
99regulation of catecholamine metabolic process (GO:0042069)2.77723612
100negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.76346656
101aldehyde catabolic process (GO:0046185)2.75718459
102nucleotide transmembrane transport (GO:1901679)2.71680582
103* trivalent inorganic cation transport (GO:0072512)2.71399162
104* ferric iron transport (GO:0015682)2.71399162
105GPI anchor biosynthetic process (GO:0006506)2.70704641
106mitochondrial transport (GO:0006839)2.70251902
107ketone body metabolic process (GO:1902224)2.70068925
108nonmotile primary cilium assembly (GO:0035058)2.70046288
109viral protein processing (GO:0019082)2.69081011
110positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.68888859
111protein localization to cilium (GO:0061512)2.68215233
112organelle disassembly (GO:1903008)2.66808363
113inositol phosphate catabolic process (GO:0071545)2.65878447
114cytochrome complex assembly (GO:0017004)2.65560111
115respiratory chain complex IV assembly (GO:0008535)2.64353985
116protein deneddylation (GO:0000338)2.63861627
117positive regulation of mitochondrial fission (GO:0090141)2.63002404
118rRNA modification (GO:0000154)2.61123139
119presynaptic membrane assembly (GO:0097105)2.60593441
120C-terminal protein amino acid modification (GO:0018410)2.59580946
121oxidative phosphorylation (GO:0006119)2.58987957
122neural nucleus development (GO:0048857)2.58036617
123eosinophil chemotaxis (GO:0048245)2.57989759
124anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.57746102
125lactate metabolic process (GO:0006089)2.57671688
126phosphorylated carbohydrate dephosphorylation (GO:0046838)2.57573639
127inositol phosphate dephosphorylation (GO:0046855)2.57573639
128positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.56124551
129negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.55819809
130adhesion of symbiont to host cell (GO:0044650)2.54506296
131virion attachment to host cell (GO:0019062)2.54506296
132regulation of cellular amine metabolic process (GO:0033238)2.53936256
133DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.53077476
134presynaptic membrane organization (GO:0097090)2.50286276
135sequestering of actin monomers (GO:0042989)2.47810479
136ribonucleoside triphosphate biosynthetic process (GO:0009201)2.46378409
137nucleoside diphosphate phosphorylation (GO:0006165)2.46332450
138negative regulation of neurotransmitter secretion (GO:0046929)2.45658941
139negative regulation of ligase activity (GO:0051352)2.45427333
140negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.45427333
141mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.44609266
142inner mitochondrial membrane organization (GO:0007007)2.43921388
143L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.43170561
144signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.42858757
145intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.42858757
146pH reduction (GO:0045851)2.41586674
147cellular copper ion homeostasis (GO:0006878)2.41251920
148negative regulation of protein localization to cell surface (GO:2000009)2.40963768
149guanosine-containing compound biosynthetic process (GO:1901070)2.39089061
150signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.39028087
151signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.39028087
152signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.39028087
153autophagic vacuole fusion (GO:0000046)2.36049682
154protein targeting to mitochondrion (GO:0006626)2.34809597

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.30387573
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.96657115
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.92574012
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.79473683
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.75475254
6ZNF274_21170338_ChIP-Seq_K562_Hela2.69782258
7VDR_22108803_ChIP-Seq_LS180_Human2.68628600
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.66813109
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66631778
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.65993852
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.45134940
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.33681246
13* VDR_23849224_ChIP-Seq_CD4+_Human2.30657912
14PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.23095959
15GBX2_23144817_ChIP-Seq_PC3_Human2.22375613
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15958758
17TAF15_26573619_Chip-Seq_HEK293_Human2.14293846
18EWS_26573619_Chip-Seq_HEK293_Human2.04766343
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.95828480
20* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92251739
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89482524
22* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.82135724
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81222974
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77788225
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74911523
26ER_23166858_ChIP-Seq_MCF-7_Human1.73043741
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73023454
28FOXP3_21729870_ChIP-Seq_TREG_Human1.72377566
29* MYC_18940864_ChIP-ChIP_HL60_Human1.72237913
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.70376745
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63458692
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.61393990
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56735478
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.56268163
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.55451646
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54848952
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.47625831
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47357709
39TP53_22573176_ChIP-Seq_HFKS_Human1.47097108
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.46355197
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45587402
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44870305
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44712273
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43732897
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43627076
46P300_19829295_ChIP-Seq_ESCs_Human1.43064512
47CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.40153992
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.39553186
49SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.38885152
50HTT_18923047_ChIP-ChIP_STHdh_Human1.34342124
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.33873287
52ELK1_19687146_ChIP-ChIP_HELA_Human1.33097770
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.32465994
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31226013
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30977168
56DCP1A_22483619_ChIP-Seq_HELA_Human1.30631195
57FUS_26573619_Chip-Seq_HEK293_Human1.29624387
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28535832
59MYC_18555785_ChIP-Seq_MESCs_Mouse1.27910391
60RNF2_27304074_Chip-Seq_NSC_Mouse1.27465565
61FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.27406580
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27247252
63RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26938038
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.26375308
65CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.25364917
66EZH2_22144423_ChIP-Seq_EOC_Human1.25307410
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24455075
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24167992
69NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20877450
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20877450
71SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.20316912
72* TTF2_22483619_ChIP-Seq_HELA_Human1.20107594
73ETS1_20019798_ChIP-Seq_JURKAT_Human1.19678602
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18418453
75TRIM28_21343339_ChIP-Seq_HEK293_Human1.18083399
76JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17511391
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.15794524
78IRF8_21731497_ChIP-ChIP_J774_Mouse1.14496733
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.12966731
80* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12596206
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.12463942
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12463942
83NOTCH1_21737748_ChIP-Seq_TLL_Human1.12265972
84SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11120318
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10949375
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10588440
87CBP_20019798_ChIP-Seq_JUKART_Human1.10588440
88HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10389049
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10056202
90AR_20517297_ChIP-Seq_VCAP_Human1.09112918
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07578262
92* GABP_19822575_ChIP-Seq_HepG2_Human1.07522428
93SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07219216
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06222447
95MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06197160
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05096967
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.04020920
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03529820
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03378985
100AR_25329375_ChIP-Seq_VCAP_Human1.02337245
101EZH2_18974828_ChIP-Seq_MESCs_Mouse1.02238900
102RNF2_18974828_ChIP-Seq_MESCs_Mouse1.02238900
103NANOG_19829295_ChIP-Seq_ESCs_Human1.02047870
104SOX2_19829295_ChIP-Seq_ESCs_Human1.02047870
105EZH2_27294783_Chip-Seq_ESCs_Mouse1.01168755
106BCAT_22108803_ChIP-Seq_LS180_Human1.01046091
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.01018099
108* SOX2_16153702_ChIP-ChIP_HESCs_Human1.00461989
109JUN_21703547_ChIP-Seq_K562_Human1.00357387
110YY1_21170310_ChIP-Seq_MESCs_Mouse1.00336513
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98851883
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97986635
113CMYC_18555785_Chip-Seq_ESCs_Mouse0.97512736
114SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96285649
115ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96259099
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95855306
117NANOG_18555785_Chip-Seq_ESCs_Mouse0.95811774
118ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95662524
119IGF1R_20145208_ChIP-Seq_DFB_Human0.93944803
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93662634
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93115465
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93032194
123* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92304634
124STAT3_18555785_Chip-Seq_ESCs_Mouse0.91975426
125* NANOG_16153702_ChIP-ChIP_HESCs_Human0.91950767
126TCF4_22108803_ChIP-Seq_LS180_Human0.91914950
127CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91797484
128REST_19997604_ChIP-ChIP_NEURONS_Mouse0.91505069
129HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91398519
130MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91311322
131P53_22387025_ChIP-Seq_ESCs_Mouse0.91041637
132TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90903742
133SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90759651
134FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90712132
135SOX17_20123909_ChIP-Seq_XEN_Mouse0.89820113
136SMAD3_21741376_ChIP-Seq_EPCs_Human0.89788183
137P300_18555785_Chip-Seq_ESCs_Mouse0.88696659
138PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87620176
139TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86373420
140RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.86240358
141FLI1_27457419_Chip-Seq_LIVER_Mouse0.86239649
142TP53_18474530_ChIP-ChIP_U2OS_Human0.85770912
143EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.85482064
144* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82851335
145SOX2_18555785_Chip-Seq_ESCs_Mouse0.82575193
146SOX2_20726797_ChIP-Seq_SW620_Human0.82547021
147CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.81937629

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001905_abnormal_dopamine_level3.56056557
2MP0001529_abnormal_vocalization3.47342962
3MP0003880_abnormal_central_pattern3.23177523
4MP0000920_abnormal_myelination2.89870970
5MP0008877_abnormal_DNA_methylation2.85170836
6MP0000372_irregular_coat_pigmentation2.78338936
7MP0002102_abnormal_ear_morphology2.61003823
8MP0005171_absent_coat_pigmentation2.58387621
9MP0006276_abnormal_autonomic_nervous2.54897460
10MP0003787_abnormal_imprinting2.46328882
11MP0003136_yellow_coat_color2.42529300
12MP0010386_abnormal_urinary_bladder2.26401852
13MP0004742_abnormal_vestibular_system2.14884901
14MP0002909_abnormal_adrenal_gland2.09218151
15MP0001984_abnormal_olfaction2.09123953
16MP0004270_analgesia2.08896701
17MP0005058_abnormal_lysosome_morphology2.04075362
18MP0005084_abnormal_gallbladder_morpholo1.93154124
19MP0004142_abnormal_muscle_tone1.91763771
20MP0005646_abnormal_pituitary_gland1.87423847
21MP0002734_abnormal_mechanical_nocicepti1.82465515
22MP0004133_heterotaxia1.81459450
23MP0005408_hypopigmentation1.79316631
24MP0003950_abnormal_plasma_membrane1.78305263
25MP0001986_abnormal_taste_sensitivity1.76321485
26MP0002272_abnormal_nervous_system1.75486548
27MP0003195_calcinosis1.75334712
28MP0003121_genomic_imprinting1.69486649
29MP0006292_abnormal_olfactory_placode1.67644999
30MP0008995_early_reproductive_senescence1.65702150
31MP0008058_abnormal_DNA_repair1.63691339
32MP0002735_abnormal_chemical_nociception1.59699083
33MP0002163_abnormal_gland_morphology1.58963274
34MP0002064_seizures1.58476536
35MP0008260_abnormal_autophagy1.57145735
36MP0003634_abnormal_glial_cell1.56433889
37MP0009046_muscle_twitch1.56252726
38MP0001542_abnormal_bone_strength1.54149687
39MP0000778_abnormal_nervous_system1.52333820
40MP0008789_abnormal_olfactory_epithelium1.52213399
41MP0005379_endocrine/exocrine_gland_phen1.51657250
42MP0002837_dystrophic_cardiac_calcinosis1.51262905
43MP0002822_catalepsy1.49421502
44MP0009379_abnormal_foot_pigmentation1.47295021
45MP0001485_abnormal_pinna_reflex1.46158100
46MP0004043_abnormal_pH_regulation1.44502555
47MP0002736_abnormal_nociception_after1.43419341
48MP0002638_abnormal_pupillary_reflex1.42622115
49MP0002148_abnormal_hypersensitivity_rea1.42405973
50MP0002277_abnormal_respiratory_mucosa1.42064490
51MP0003283_abnormal_digestive_organ1.41833222
52MP0001970_abnormal_pain_threshold1.41453006
53MP0005409_darkened_coat_color1.40782857
54MP0002751_abnormal_autonomic_nervous1.34985350
55MP0001968_abnormal_touch/_nociception1.34608661
56MP0000647_abnormal_sebaceous_gland1.33666063
57MP0006082_CNS_inflammation1.33473792
58MP0005075_abnormal_melanosome_morpholog1.33447403
59MP0001727_abnormal_embryo_implantation1.33422453
60MP0002733_abnormal_thermal_nociception1.30182719
61MP0002295_abnormal_pulmonary_circulatio1.26528714
62MP0003186_abnormal_redox_activity1.23542806
63MP0001188_hyperpigmentation1.23358668
64MP0002938_white_spotting1.23101907
65MP0001440_abnormal_grooming_behavior1.22953736
66MP0002229_neurodegeneration1.22410955
67MP0002067_abnormal_sensory_capabilities1.22366487
68MP0001486_abnormal_startle_reflex1.20788600
69MP0006072_abnormal_retinal_apoptosis1.18970935
70MP0003890_abnormal_embryonic-extraembry1.18813867
71MP0009745_abnormal_behavioral_response1.18605864
72MP0005551_abnormal_eye_electrophysiolog1.17974110
73MP0006035_abnormal_mitochondrial_morpho1.16087323
74MP0002693_abnormal_pancreas_physiology1.15616473
75MP0003718_maternal_effect1.14918769
76MP0003786_premature_aging1.14778088
77MP0002572_abnormal_emotion/affect_behav1.14671776
78MP0001944_abnormal_pancreas_morphology1.14242242
79MP0002876_abnormal_thyroid_physiology1.13931699
80MP0005645_abnormal_hypothalamus_physiol1.13695136
81MP0001963_abnormal_hearing_physiology1.11885584
82MP0003690_abnormal_glial_cell1.10862069
83MP0002090_abnormal_vision1.09135075
84MP0008875_abnormal_xenobiotic_pharmacok1.08891070
85MP0004924_abnormal_behavior1.08341253
86MP0005386_behavior/neurological_phenoty1.08341253
87MP0003329_amyloid_beta_deposits1.07520467
88MP0002653_abnormal_ependyma_morphology1.07259297
89MP0005410_abnormal_fertilization1.06855341
90MP0001764_abnormal_homeostasis1.06243884
91MP0005253_abnormal_eye_physiology1.05217048
92MP0003122_maternal_imprinting1.03602101
93MP0008872_abnormal_physiological_respon1.03267671
94MP0002184_abnormal_innervation1.02821522
95MP0000026_abnormal_inner_ear1.02709379
96MP0005367_renal/urinary_system_phenotyp1.02299526
97MP0000516_abnormal_urinary_system1.02299526
98MP0002752_abnormal_somatic_nervous1.02119486
99MP0000538_abnormal_urinary_bladder1.01957828
100MP0005389_reproductive_system_phenotype1.01922592
101MP0004885_abnormal_endolymph1.01584550
102MP0004019_abnormal_vitamin_homeostasis1.01234514
103MP0001346_abnormal_lacrimal_gland1.00828333
104MP0002882_abnormal_neuron_morphology1.00296174
105MP0001919_abnormal_reproductive_system0.98718805
106MP0002095_abnormal_skin_pigmentation0.97075724
107MP0005187_abnormal_penis_morphology0.97058878
108MP0004134_abnormal_chest_morphology0.96931148
109MP0000427_abnormal_hair_cycle0.94411979
110MP0000681_abnormal_thyroid_gland0.93744337
111MP0005499_abnormal_olfactory_system0.93247886
112MP0005394_taste/olfaction_phenotype0.93247886
113MP0001324_abnormal_eye_pigmentation0.92975240
114MP0002160_abnormal_reproductive_system0.92900005
115MP0003011_delayed_dark_adaptation0.91521699
116MP0002210_abnormal_sex_determination0.88389590
117MP0005636_abnormal_mineral_homeostasis0.87950417
118MP0002066_abnormal_motor_capabilities/c0.87065543
119MP0009250_abnormal_appendicular_skeleto0.86812318
120MP0005164_abnormal_response_to0.86289495
121MP0000639_abnormal_adrenal_gland0.86154930
122MP0004381_abnormal_hair_follicle0.85823848
123MP0005332_abnormal_amino_acid0.84641871
124MP0006036_abnormal_mitochondrial_physio0.84559726
125MP0003806_abnormal_nucleotide_metabolis0.83357870
126MP0009785_altered_susceptibility_to0.83284547
127MP0003635_abnormal_synaptic_transmissio0.83230936
128MP0001299_abnormal_eye_distance/0.83003259
129MP0003123_paternal_imprinting0.82990165
130MP0005391_vision/eye_phenotype0.82680875
131MP0000653_abnormal_sex_gland0.82112370
132MP0002254_reproductive_system_inflammat0.81115263
133MP0001929_abnormal_gametogenesis0.80872983
134MP0001756_abnormal_urination0.80016918
135MP0000749_muscle_degeneration0.78557226
136MP0002063_abnormal_learning/memory/cond0.78083849
137MP0003632_abnormal_nervous_system0.77964322
138MP0008004_abnormal_stomach_pH0.77939456
139MP0003567_abnormal_fetal_cardiomyocyte0.77920347
140MP0002332_abnormal_exercise_endurance0.76956146
141MP0005423_abnormal_somatic_nervous0.76930428
142MP0002557_abnormal_social/conspecific_i0.76717412
143MP0000631_abnormal_neuroendocrine_gland0.76381691
144MP0003183_abnormal_peptide_metabolism0.75567777
145MP0005195_abnormal_posterior_eye0.75421217
146MP0001293_anophthalmia0.75144399
147MP0001502_abnormal_circadian_rhythm0.74759950
148MP0000955_abnormal_spinal_cord0.71385658

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.67554416
2Abnormal mitochondria in muscle tissue (HP:0008316)5.00838475
3Mitochondrial inheritance (HP:0001427)4.90424523
4Progressive macrocephaly (HP:0004481)4.64953947
5Acute encephalopathy (HP:0006846)4.40010986
6Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.13773369
7Parakeratosis (HP:0001036)4.10640445
8Hepatocellular necrosis (HP:0001404)3.96442987
9Renal Fanconi syndrome (HP:0001994)3.87822162
10Increased CSF lactate (HP:0002490)3.86672873
11Increased hepatocellular lipid droplets (HP:0006565)3.75005030
12Abnormality of glycolysis (HP:0004366)3.69231941
13Increased serum pyruvate (HP:0003542)3.69231941
14Hypothermia (HP:0002045)3.51718360
15Neuroendocrine neoplasm (HP:0100634)3.47438533
16Pheochromocytoma (HP:0002666)3.45769280
17Hepatic necrosis (HP:0002605)3.31835035
18Lipid accumulation in hepatocytes (HP:0006561)3.30678103
19Limb dystonia (HP:0002451)3.26910280
20Leukodystrophy (HP:0002415)3.21539238
21Optic disc pallor (HP:0000543)3.14071226
223-Methylglutaconic aciduria (HP:0003535)3.06749530
23Pancreatic cysts (HP:0001737)3.05649801
24Respiratory failure (HP:0002878)3.05397589
25Neurofibrillary tangles (HP:0002185)3.04375763
26Congenital ichthyosiform erythroderma (HP:0007431)3.02373136
27Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.00917277
28Degeneration of the lateral corticospinal tracts (HP:0002314)3.00917277
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.89473626
30Abnormality of renal resorption (HP:0011038)2.87487074
31Pancreatic fibrosis (HP:0100732)2.82914041
32Medial flaring of the eyebrow (HP:0010747)2.80107826
33Molar tooth sign on MRI (HP:0002419)2.77538161
34Abnormality of midbrain morphology (HP:0002418)2.77538161
35Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.73857933
36Sensory axonal neuropathy (HP:0003390)2.68094342
37Exercise intolerance (HP:0003546)2.63990057
38Exertional dyspnea (HP:0002875)2.58696968
39Methylmalonic aciduria (HP:0012120)2.56984677
40Cerebral edema (HP:0002181)2.54701920
41Gait imbalance (HP:0002141)2.54123393
42Vaginal atresia (HP:0000148)2.53204050
43Increased intramyocellular lipid droplets (HP:0012240)2.52306844
44Abnormal number of erythroid precursors (HP:0012131)2.48349463
45Congenital, generalized hypertrichosis (HP:0004540)2.46122942
46Congenital primary aphakia (HP:0007707)2.45435731
47Genital tract atresia (HP:0001827)2.45429717
48Hypoglycemic coma (HP:0001325)2.44135147
49Nephronophthisis (HP:0000090)2.39586389
50Autoamputation (HP:0001218)2.39482879
51Cerebral hemorrhage (HP:0001342)2.39247994
52Hypoglycemic seizures (HP:0002173)2.37938267
53Hyperinsulinemic hypoglycemia (HP:0000825)2.37175437
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.33463848
55Decreased activity of mitochondrial respiratory chain (HP:0008972)2.33463848
56Nephrogenic diabetes insipidus (HP:0009806)2.33336598
57Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.32038048
58Intestinal atresia (HP:0011100)2.32016611
59Degeneration of anterior horn cells (HP:0002398)2.29503818
60Abnormality of the anterior horn cell (HP:0006802)2.29503818
61Lethargy (HP:0001254)2.28065731
62Retinal dysplasia (HP:0007973)2.28049586
63Vacuolated lymphocytes (HP:0001922)2.27385530
64Abnormality of cells of the erythroid lineage (HP:0012130)2.21913452
65Lactic acidosis (HP:0003128)2.20825475
66Patchy hypopigmentation of hair (HP:0011365)2.20645779
67Abnormal pupillary function (HP:0007686)2.18822190
68Ketoacidosis (HP:0001993)2.15454557
69Large for gestational age (HP:0001520)2.12818749
70Abnormality of the labia minora (HP:0012880)2.11833345
71Generalized aminoaciduria (HP:0002909)2.08918861
72X-linked dominant inheritance (HP:0001423)2.05972940
73Abnormality of aromatic amino acid family metabolism (HP:0004338)2.05914522
74Abnormality of vitamin B metabolism (HP:0004340)2.03253204
75Renal cortical cysts (HP:0000803)2.03081992
76Cerebral inclusion bodies (HP:0100314)2.02237979
77Male pseudohermaphroditism (HP:0000037)2.02235084
78Increased serum lactate (HP:0002151)2.01788324
79Increased muscle lipid content (HP:0009058)2.01740577
80Abolished electroretinogram (ERG) (HP:0000550)2.01569256
81Macrocytic anemia (HP:0001972)2.01235895
82Abnormality of the renal cortex (HP:0011035)2.00926587
83Abnormality of the renal medulla (HP:0100957)1.98896732
84Cerebral hypomyelination (HP:0006808)1.98510044
85Increased neuronal autofluorescent lipopigment (HP:0002074)1.98367591
86Akinesia (HP:0002304)1.95724116
87Glycosuria (HP:0003076)1.94721621
88Abnormality of urine glucose concentration (HP:0011016)1.94721621
89Abnormal hair whorl (HP:0010721)1.94638478
90Hepatosplenomegaly (HP:0001433)1.94372434
91Type I transferrin isoform profile (HP:0003642)1.94247083
92Aplastic anemia (HP:0001915)1.93488812
93Abnormality of macrophages (HP:0004311)1.91817395
94Hypomagnesemia (HP:0002917)1.89622895
95Hyperglycinemia (HP:0002154)1.88952494
96Rhinitis (HP:0012384)1.84272445
97Methylmalonic acidemia (HP:0002912)1.84211987
98Abnormality of methionine metabolism (HP:0010901)1.83904067
99Prolonged neonatal jaundice (HP:0006579)1.83255309
100Hyperphosphaturia (HP:0003109)1.83031489
101Congenital stationary night blindness (HP:0007642)1.82788329
102Muscular hypotonia of the trunk (HP:0008936)1.79465744
103Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.76781437
104Congenital sensorineural hearing impairment (HP:0008527)1.76543974
105Aplasia/Hypoplasia of the lens (HP:0008063)1.76290562
106Sclerocornea (HP:0000647)1.76238614
107Diminished movement (HP:0002374)1.76197652
108Abnormal respiratory motile cilium morphology (HP:0005938)1.76067037
109Abnormal respiratory epithelium morphology (HP:0012253)1.76067037
110CNS demyelination (HP:0007305)1.75832236
111Supranuclear gaze palsy (HP:0000605)1.74838850
112Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74562119
113Agitation (HP:0000713)1.74236816
114Progressive neurologic deterioration (HP:0002344)1.74102445
115Abnormality of alanine metabolism (HP:0010916)1.73643622
116Hyperalaninemia (HP:0003348)1.73643622
117Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73643622
118White forelock (HP:0002211)1.73642601
119Abnormality of the corticospinal tract (HP:0002492)1.73279921
120Abnormality of liposaccharide metabolism (HP:0010968)1.71267369
121Abnormality of glycosphingolipid metabolism (HP:0004343)1.71267369
122Abnormality of glycolipid metabolism (HP:0010969)1.71267369
123Ketosis (HP:0001946)1.70975442
124Abnormal glycosylation (HP:0012345)1.70874581
125Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.70874581
126Abnormal protein N-linked glycosylation (HP:0012347)1.70874581
127Abnormal protein glycosylation (HP:0012346)1.70874581
128Abnormality of placental membranes (HP:0011409)1.70586836
129Amniotic constriction ring (HP:0009775)1.70586836
130Myokymia (HP:0002411)1.69921524
131Abnormal ciliary motility (HP:0012262)1.69434980
132Adrenal hypoplasia (HP:0000835)1.68690082
133Furrowed tongue (HP:0000221)1.68432670
134Abnormality of magnesium homeostasis (HP:0004921)1.67845791
135Metaphyseal dysplasia (HP:0100255)1.67332575
136Anencephaly (HP:0002323)1.67269911
137Abnormality of macular pigmentation (HP:0008002)1.66805887
138Aplasia/Hypoplasia of the tongue (HP:0010295)1.65839722
139Renal tubular dysfunction (HP:0000124)1.65155168
140Respiratory difficulties (HP:0002880)1.62283844
141Abnormal urine phosphate concentration (HP:0012599)1.61581909
142Axonal loss (HP:0003447)1.61109089
143True hermaphroditism (HP:0010459)1.59843646
144Abnormal autonomic nervous system physiology (HP:0012332)1.59305762
145Aplasia/hypoplasia of the uterus (HP:0008684)1.58067127
146Stridor (HP:0010307)1.57935834
147Delayed gross motor development (HP:0002194)1.56206206
148Atonic seizures (HP:0010819)1.55817171
149Peripheral hypomyelination (HP:0007182)1.54153649
150Poor suck (HP:0002033)1.53761189
151Abnormal respiratory motile cilium physiology (HP:0012261)1.53274543
152Increased cerebral lipofuscin (HP:0011813)1.52998091

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.05177483
2PBK3.78917907
3BCR3.18150439
4CASK3.10129689
5FRK2.94943088
6OXSR12.94838189
7MAP4K22.70655253
8MST42.70219906
9TRIM282.61059689
10LIMK12.54614957
11WNK42.37952789
12ARAF2.31780288
13MAPKAPK52.20713845
14MAP3K122.11304828
15MAP3K42.02778298
16STK161.98389068
17VRK21.97582645
18ZAK1.95648632
19NME11.84970246
20CSNK1G31.67304856
21SRPK11.62578272
22DYRK21.61433457
23NME21.59351563
24PIM21.55481290
25BMPR21.54682648
26BCKDK1.48000125
27BMPR1B1.47121227
28NUAK11.46828533
29CDK191.45823454
30MET1.43862092
31PASK1.42235684
32GRK51.41114861
33TNIK1.37087893
34TESK11.36537841
35GRK71.36411408
36EPHB11.35129839
37DYRK31.35109399
38FGFR21.32395253
39UHMK11.31265027
40PINK11.30408697
41MUSK1.27362951
42ACVR1B1.27256788
43ERBB31.25729714
44PKN11.23739455
45ADRBK21.22999493
46CAMK2B1.20274699
47PLK31.20056704
48MYLK1.18368599
49PLK21.17224266
50FGR1.16916065
51CAMK2D1.11720816
52BRAF1.11181456
53CSNK1G11.08601961
54MAPK151.05173768
55CSNK1G21.04319742
56TXK1.04265112
57CSNK1A1L1.04025362
58BLK1.03946180
59MKNK20.99392403
60NEK60.96681796
61VRK10.96498676
62PRKCG0.96366890
63INSRR0.96273469
64MAPK130.96071963
65NTRK10.95038242
66MARK10.93291056
67ROCK20.89744746
68ABL20.89032912
69IRAK40.88686940
70STK38L0.88208385
71WEE10.86634146
72PRKCE0.85282064
73STK240.84451790
74CAMK2A0.83277372
75RPS6KA50.83164837
76YES10.82787182
77TESK20.81199535
78CDK140.80257128
79TSSK60.79619541
80PDK20.78864835
81CAMK2G0.77433466
82WNK10.77428043
83IRAK20.77321340
84WNK30.76929596
85EIF2AK30.76284302
86ADRBK10.75476333
87PNCK0.72571623
88TAF10.72238869
89MOS0.70638815
90OBSCN0.68023719
91IRAK10.66204783
92PHKG10.65912221
93PHKG20.65912221
94ERBB40.64670424
95RPS6KA40.62391402
96PRPF4B0.62128700
97TLK10.61663612
98SGK2230.61369421
99SGK4940.61369421
100PTK2B0.60664065
101MAP2K70.60317971
102TRPM70.60208969
103CDK180.58969614
104DAPK30.58411811
105NTRK30.57087428
106BUB10.56307984
107FER0.55635346
108PIK3CG0.55425194
109CDK150.54839669
110PLK10.54607675
111BRSK20.54361563
112MINK10.54094802
113PLK40.52609928
114CDK30.51903374
115CSNK2A10.51622731
116TAOK30.50974290
117PAK30.50890841
118CDK11A0.49495310
119MAP2K20.48295556
120MAP3K140.46247704
121CDC70.45994748
122CSNK2A20.45800813
123RIPK40.43128914
124TGFBR10.42783629
125MST1R0.41819848
126CDK50.41482852
127PAK10.39453161
128MKNK10.39416347
129NEK10.38910426
130PRKACA0.38674160
131CAMKK20.37646192
132TBK10.36850370
133IKBKB0.36325238
134DAPK20.36322261
135PRKCQ0.36030183
136GRK10.35785933
137ILK0.35153706
138MAP2K40.34412963
139PRKCD0.34195613
140CSNK1A10.33972475
141DYRK1A0.33896630
142CSNK1E0.33883024
143EIF2AK10.32859135
144PRKCI0.32758741
145SIK30.32753587
146EPHA30.32096606

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001905.42487319
2Parkinsons disease_Homo sapiens_hsa050124.44208746
3Protein export_Homo sapiens_hsa030603.69794250
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.57704774
5Proteasome_Homo sapiens_hsa030503.50670650
6Alzheimers disease_Homo sapiens_hsa050103.40300871
7Huntingtons disease_Homo sapiens_hsa050163.01675082
8Steroid biosynthesis_Homo sapiens_hsa001002.83800328
9* Collecting duct acid secretion_Homo sapiens_hsa049662.78308732
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.73849784
11Fatty acid elongation_Homo sapiens_hsa000622.41439135
12* Vibrio cholerae infection_Homo sapiens_hsa051102.28978210
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24883020
14Sulfur metabolism_Homo sapiens_hsa009201.99143238
15Ribosome_Homo sapiens_hsa030101.97328469
16* Rheumatoid arthritis_Homo sapiens_hsa053231.94814889
17SNARE interactions in vesicular transport_Homo sapiens_hsa041301.88611455
18Cardiac muscle contraction_Homo sapiens_hsa042601.70924092
19Ether lipid metabolism_Homo sapiens_hsa005651.68266645
20* Phagosome_Homo sapiens_hsa041451.64405561
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49849742
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47406836
23RNA degradation_Homo sapiens_hsa030181.45863827
24* Synaptic vesicle cycle_Homo sapiens_hsa047211.42510248
25Propanoate metabolism_Homo sapiens_hsa006401.42332882
26Sphingolipid metabolism_Homo sapiens_hsa006001.41002485
27RNA polymerase_Homo sapiens_hsa030201.40694924
28* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.34618499
29Lysosome_Homo sapiens_hsa041421.33930641
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.28711708
31Homologous recombination_Homo sapiens_hsa034401.25260187
32Mismatch repair_Homo sapiens_hsa034301.23841879
33Serotonergic synapse_Homo sapiens_hsa047261.14812783
34Tryptophan metabolism_Homo sapiens_hsa003801.11175930
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.09254520
36Phototransduction_Homo sapiens_hsa047441.04791997
37Spliceosome_Homo sapiens_hsa030401.04474166
38Selenocompound metabolism_Homo sapiens_hsa004501.03077319
39Arachidonic acid metabolism_Homo sapiens_hsa005900.98579099
40Primary bile acid biosynthesis_Homo sapiens_hsa001200.97912900
41Nucleotide excision repair_Homo sapiens_hsa034200.91584320
42RNA transport_Homo sapiens_hsa030130.91414802
43Nitrogen metabolism_Homo sapiens_hsa009100.87525623
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86417461
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86305008
46Graft-versus-host disease_Homo sapiens_hsa053320.85691100
47Regulation of autophagy_Homo sapiens_hsa041400.83310503
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82315074
49Other glycan degradation_Homo sapiens_hsa005110.80780838
50Linoleic acid metabolism_Homo sapiens_hsa005910.79192437
51Fanconi anemia pathway_Homo sapiens_hsa034600.78172805
52Autoimmune thyroid disease_Homo sapiens_hsa053200.78044477
53Non-homologous end-joining_Homo sapiens_hsa034500.77988808
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77504071
55Allograft rejection_Homo sapiens_hsa053300.77036620
56Asthma_Homo sapiens_hsa053100.73517701
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.70846964
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70620409
59Chemical carcinogenesis_Homo sapiens_hsa052040.70348877
60Caffeine metabolism_Homo sapiens_hsa002320.69976611
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69921456
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69717598
63Histidine metabolism_Homo sapiens_hsa003400.68719202
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67693683
65Glutathione metabolism_Homo sapiens_hsa004800.67544510
66Tyrosine metabolism_Homo sapiens_hsa003500.66896707
67Vitamin B6 metabolism_Homo sapiens_hsa007500.64780333
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63744374
69Malaria_Homo sapiens_hsa051440.62891826
70Cocaine addiction_Homo sapiens_hsa050300.62371957
71* Metabolic pathways_Homo sapiens_hsa011000.62089865
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61411075
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60813856
74Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59485507
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59181268
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58744316
77One carbon pool by folate_Homo sapiens_hsa006700.58685613
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58618121
79Type I diabetes mellitus_Homo sapiens_hsa049400.58461118
80beta-Alanine metabolism_Homo sapiens_hsa004100.56997685
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56937880
82Axon guidance_Homo sapiens_hsa043600.56688294
83GABAergic synapse_Homo sapiens_hsa047270.52798192
84Retinol metabolism_Homo sapiens_hsa008300.51138655
85Base excision repair_Homo sapiens_hsa034100.49951109
86Pertussis_Homo sapiens_hsa051330.49904150
87Basal transcription factors_Homo sapiens_hsa030220.49380261
88Folate biosynthesis_Homo sapiens_hsa007900.49055386
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.49035167
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48609640
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48088959
92Dopaminergic synapse_Homo sapiens_hsa047280.47615630
93Mineral absorption_Homo sapiens_hsa049780.44233710
94Salmonella infection_Homo sapiens_hsa051320.43733279
95Circadian rhythm_Homo sapiens_hsa047100.43382468
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42517194
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.42281257
98Taste transduction_Homo sapiens_hsa047420.41750132
99Fatty acid metabolism_Homo sapiens_hsa012120.39613250
100Phenylalanine metabolism_Homo sapiens_hsa003600.39271062
101Nicotine addiction_Homo sapiens_hsa050330.39182366
102Insulin secretion_Homo sapiens_hsa049110.38520671
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38094709
104Pyruvate metabolism_Homo sapiens_hsa006200.37486182
105DNA replication_Homo sapiens_hsa030300.37311464
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37170611
107Alcoholism_Homo sapiens_hsa050340.36309924
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35859904
109Fatty acid degradation_Homo sapiens_hsa000710.34964346
110N-Glycan biosynthesis_Homo sapiens_hsa005100.34324703
111Shigellosis_Homo sapiens_hsa051310.33774241
112Arginine and proline metabolism_Homo sapiens_hsa003300.33304916
113Morphine addiction_Homo sapiens_hsa050320.31615231
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31326647
115Tuberculosis_Homo sapiens_hsa051520.31002425
116Long-term depression_Homo sapiens_hsa047300.30936338
117Peroxisome_Homo sapiens_hsa041460.30216492
118Cholinergic synapse_Homo sapiens_hsa047250.29259053
119Renal cell carcinoma_Homo sapiens_hsa052110.28371773
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27218612
121Butanoate metabolism_Homo sapiens_hsa006500.26986510
122Vitamin digestion and absorption_Homo sapiens_hsa049770.26272222
123Tight junction_Homo sapiens_hsa045300.26024030
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25024590
125Endocytosis_Homo sapiens_hsa041440.24298814
126Fat digestion and absorption_Homo sapiens_hsa049750.23828288
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.23525781
128Legionellosis_Homo sapiens_hsa051340.23412576
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22662371
130Olfactory transduction_Homo sapiens_hsa047400.21717176
131Ras signaling pathway_Homo sapiens_hsa040140.19942217
132Pyrimidine metabolism_Homo sapiens_hsa002400.19828301
133Purine metabolism_Homo sapiens_hsa002300.19592482
134Glutamatergic synapse_Homo sapiens_hsa047240.18537553
135African trypanosomiasis_Homo sapiens_hsa051430.18343870
136Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16604830
137Epstein-Barr virus infection_Homo sapiens_hsa051690.16068032
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15941833
139Amphetamine addiction_Homo sapiens_hsa050310.15448986
140Circadian entrainment_Homo sapiens_hsa047130.14778729
141Prion diseases_Homo sapiens_hsa050200.13863640
142Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.10455125

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