ATP6AP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.07889573
2ATP hydrolysis coupled proton transport (GO:0015991)4.88143714
3energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.88143714
4neuron cell-cell adhesion (GO:0007158)4.74753334
5transferrin transport (GO:0033572)4.73653036
6regulation of synaptic vesicle exocytosis (GO:2000300)4.45491755
7ferric iron transport (GO:0015682)4.42871256
8trivalent inorganic cation transport (GO:0072512)4.42871256
9neuronal action potential propagation (GO:0019227)4.40790255
10presynaptic membrane assembly (GO:0097105)4.38974635
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.34168740
12negative regulation of synaptic transmission, GABAergic (GO:0032229)4.26152767
13vocalization behavior (GO:0071625)4.18782056
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.10747819
15gamma-aminobutyric acid signaling pathway (GO:0007214)4.09534826
16glutamate secretion (GO:0014047)4.06592409
17presynaptic membrane organization (GO:0097090)4.06159668
18oligosaccharide catabolic process (GO:0009313)4.05227418
19phagosome maturation (GO:0090382)4.01983086
20regulation of synaptic vesicle transport (GO:1902803)3.89421271
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.80862619
22neuron-neuron synaptic transmission (GO:0007270)3.79504747
23glycosphingolipid catabolic process (GO:0046479)3.70897735
24protein localization to synapse (GO:0035418)3.68843212
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.68806685
26neurotransmitter secretion (GO:0007269)3.65600362
27amino sugar catabolic process (GO:0046348)3.63922969
28keratan sulfate catabolic process (GO:0042340)3.61139034
29regulation of glutamate receptor signaling pathway (GO:1900449)3.54806119
30synaptic vesicle docking involved in exocytosis (GO:0016081)3.52220947
31postsynaptic membrane organization (GO:0001941)3.47049415
32ionotropic glutamate receptor signaling pathway (GO:0035235)3.46281179
33positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.42664351
34neurotransmitter-gated ion channel clustering (GO:0072578)3.42053488
35long-term synaptic potentiation (GO:0060291)3.40164879
36negative regulation of neurotransmitter transport (GO:0051589)3.39781714
37synaptic transmission, glutamatergic (GO:0035249)3.38520021
38glycolipid catabolic process (GO:0019377)3.33703524
39response to histamine (GO:0034776)3.33547502
40glutamate receptor signaling pathway (GO:0007215)3.29926269
41synaptic vesicle maturation (GO:0016188)3.28778385
42detection of calcium ion (GO:0005513)3.27649657
43startle response (GO:0001964)3.24775059
44membrane lipid catabolic process (GO:0046466)3.23564211
45sphingolipid catabolic process (GO:0030149)3.20953799
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.20106410
47neurotransmitter transport (GO:0006836)3.19762759
48glucosamine-containing compound catabolic process (GO:1901072)3.14195438
49negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.13991080
50ceramide catabolic process (GO:0046514)3.13385615
51regulation of mononuclear cell migration (GO:0071675)3.13005671
52eosinophil chemotaxis (GO:0048245)3.04112126
53regulation of glutamate secretion (GO:0014048)3.03112714
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.02110196
55synaptic vesicle transport (GO:0048489)3.01799616
56establishment of synaptic vesicle localization (GO:0097480)3.01799616
57regulation of vesicle fusion (GO:0031338)3.01009793
58gamma-aminobutyric acid transport (GO:0015812)3.00307198
59neuron recognition (GO:0008038)2.97662966
60intracellular pH reduction (GO:0051452)2.97606306
61signal peptide processing (GO:0006465)2.93605647
62regulation of long-term neuronal synaptic plasticity (GO:0048169)2.91958867
63regulation of synaptic transmission, glutamatergic (GO:0051966)2.91791372
64regulation of neurotransmitter levels (GO:0001505)2.91727777
65positive regulation of synapse assembly (GO:0051965)2.91606718
66proline transport (GO:0015824)2.91038022
67regulation of neurotransmitter secretion (GO:0046928)2.90730292
68regulation of excitatory postsynaptic membrane potential (GO:0060079)2.90207892
69locomotory exploration behavior (GO:0035641)2.89087348
70synaptic transmission, dopaminergic (GO:0001963)2.87672846
71regulation of dopamine metabolic process (GO:0042053)2.85977141
72regulation of catecholamine metabolic process (GO:0042069)2.85977141
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.85129019
74behavioral response to cocaine (GO:0048148)2.85114492
75synaptic vesicle endocytosis (GO:0048488)2.84629279
76regulation of synaptic transmission, GABAergic (GO:0032228)2.83631118
77neuromuscular process controlling posture (GO:0050884)2.83559053
78pH reduction (GO:0045851)2.82942144
79regulation of postsynaptic membrane potential (GO:0060078)2.80167660
80ganglioside metabolic process (GO:0001573)2.80132143
81regulation of neuronal synaptic plasticity (GO:0048168)2.79928504
82negative regulation of dendrite morphogenesis (GO:0050774)2.79172236
83neurotransmitter uptake (GO:0001504)2.78784217
84transmission of nerve impulse (GO:0019226)2.78554401
85positive regulation of neurotransmitter transport (GO:0051590)2.78227469
86regulation of neurotransmitter transport (GO:0051588)2.78070182
87response to cocaine (GO:0042220)2.78055919
88mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.78001585
89protein localization to cilium (GO:0061512)2.77777050
90positive regulation of synaptic transmission, GABAergic (GO:0032230)2.77399644
91positive regulation of membrane potential (GO:0045838)2.76068953
92iron ion transport (GO:0006826)2.75148958
93mechanosensory behavior (GO:0007638)2.74394660
94long-chain fatty acid biosynthetic process (GO:0042759)2.74278900
95eosinophil migration (GO:0072677)2.73847413
96positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.73255772
97establishment of vesicle localization (GO:0051650)2.72732304
98dopamine biosynthetic process (GO:0042416)2.71996760
99positive regulation of calcium ion import (GO:0090280)2.71497662
100regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.70908026
101regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.70908026
102synaptic transmission (GO:0007268)2.70806532
103regulation of exocytosis (GO:0017157)2.70578983
104chaperone-mediated protein transport (GO:0072321)2.70215668
105negative regulation of amine transport (GO:0051953)2.68114851
106lysosome organization (GO:0007040)2.67771669
107lytic vacuole organization (GO:0080171)2.67771669
108exploration behavior (GO:0035640)2.67653107
109regulation of synaptic plasticity (GO:0048167)2.67297375
110cerebellar granule cell differentiation (GO:0021707)2.66317477
111dopamine transport (GO:0015872)2.66226114
112positive regulation of exocytosis (GO:0045921)2.66132637
113synapse assembly (GO:0007416)2.64655644
114negative regulation of synaptic transmission (GO:0050805)2.64519850
115female mating behavior (GO:0060180)2.63615579
116respiratory electron transport chain (GO:0022904)2.63074565
117protein neddylation (GO:0045116)2.62207642
118positive regulation of synaptic transmission (GO:0050806)2.60583299
119ER overload response (GO:0006983)2.60192901
120neutrophil activation involved in immune response (GO:0002283)2.55661795
121response to lipoprotein particle (GO:0055094)2.54653849
122positive regulation of cellular amide metabolic process (GO:0034250)2.54030267
123regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.53347894
124positive regulation of monocyte chemotaxis (GO:0090026)2.52811216
125cellular iron ion homeostasis (GO:0006879)2.49227852
126regulation of beta-amyloid formation (GO:1902003)2.47998870
127cellular response to thyroid hormone stimulus (GO:0097067)2.46282618
128sphingosine metabolic process (GO:0006670)2.44659189
129macroautophagy (GO:0016236)2.44541363
130glycosphingolipid metabolic process (GO:0006687)2.43818654
131glycerophospholipid catabolic process (GO:0046475)2.43393327
132regulation of fever generation (GO:0031620)2.38883630
133chondroitin sulfate catabolic process (GO:0030207)2.38663820
134positive regulation of actin filament depolymerization (GO:0030836)2.35995782
135N-acetylneuraminate metabolic process (GO:0006054)2.32716419
136alanine transport (GO:0032328)2.30852286
137cellular transition metal ion homeostasis (GO:0046916)2.30318632
138positive regulation of heat generation (GO:0031652)2.29938453
139negative regulation of nitric oxide biosynthetic process (GO:0045019)2.29448884
140platelet dense granule organization (GO:0060155)2.24891629
141negative regulation of interleukin-12 production (GO:0032695)2.24167629
142regulation of integrin-mediated signaling pathway (GO:2001044)2.20215257
143inositol phosphate catabolic process (GO:0071545)2.20028128
144magnesium ion transport (GO:0015693)2.18762951
145diol metabolic process (GO:0034311)2.17472382
146prostate gland growth (GO:0060736)2.17457177
147regulation of type B pancreatic cell apoptotic process (GO:2000674)2.16748335
148positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.16367199
149xenobiotic catabolic process (GO:0042178)2.16312569
150COPI coating of Golgi vesicle (GO:0048205)2.10502619
151Golgi transport vesicle coating (GO:0048200)2.10502619
152inositol phosphate-mediated signaling (GO:0048016)2.09899808
153inositol phosphate dephosphorylation (GO:0046855)2.07309627
154phosphorylated carbohydrate dephosphorylation (GO:0046838)2.07309627
155regulation of amyloid precursor protein catabolic process (GO:1902991)2.07155463
156insulin secretion (GO:0030073)2.06224599
157response to dietary excess (GO:0002021)2.05869511
158transition metal ion transport (GO:0000041)2.05804965
159nitric oxide biosynthetic process (GO:0006809)2.03720423
160* peptide hormone processing (GO:0016486)2.03587134
161amyloid precursor protein catabolic process (GO:0042987)2.03410172
162response to hydroperoxide (GO:0033194)2.03126394
163positive regulation of osteoclast differentiation (GO:0045672)2.02948736
164response to thyroid hormone (GO:0097066)2.02738608
165cell adhesion mediated by integrin (GO:0033627)2.02480092
166regulation of monocyte chemotaxis (GO:0090025)2.02417917
167vasodilation (GO:0042311)2.02335100
168regulation of autophagic vacuole assembly (GO:2000785)2.02157672
169regulation of heat generation (GO:0031650)2.01652062
170regulation of intracellular pH (GO:0051453)1.99508040
171sphingoid metabolic process (GO:0046519)1.99285107
172sphingolipid metabolic process (GO:0006665)1.99269100
173glycolipid metabolic process (GO:0006664)1.98469267
174regulation of ER to Golgi vesicle-mediated transport (GO:0060628)1.98170062
175protein localization to endosome (GO:0036010)1.97903809
176negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)1.96568839
177glycosphingolipid biosynthetic process (GO:0006688)1.96374619
178zinc ion transport (GO:0006829)1.96310508
179positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610811.96006997
180liposaccharide metabolic process (GO:1903509)1.95771029
181cellular copper ion homeostasis (GO:0006878)1.95463033
182vitamin D metabolic process (GO:0042359)1.94547829
183positive regulation of protein autophosphorylation (GO:0031954)1.94462136
184positive regulation of leukocyte degranulation (GO:0043302)1.93518429
185regulation of vacuole organization (GO:0044088)1.92754335
186endoplasmic reticulum calcium ion homeostasis (GO:0032469)1.92655616
187positive regulation of interleukin-8 biosynthetic process (GO:0045416)1.91986778

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.76224386
2GBX2_23144817_ChIP-Seq_PC3_Human4.59123202
3TAF15_26573619_Chip-Seq_HEK293_Human3.35815522
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.00416460
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.90470592
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71462976
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.63921292
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.54560723
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.49007211
10REST_21632747_ChIP-Seq_MESCs_Mouse2.48847714
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.48644916
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41929931
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.37605752
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34650801
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25371923
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20922218
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.20235883
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.18767994
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17406635
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.11816117
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.10405284
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.08722717
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08704071
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05286115
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.05226485
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.01897738
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.01753810
28* P300_19829295_ChIP-Seq_ESCs_Human2.00203132
29IGF1R_20145208_ChIP-Seq_DFB_Human1.99299540
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.97530069
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.97530069
32VDR_22108803_ChIP-Seq_LS180_Human1.94930168
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.94223494
34SMAD4_21799915_ChIP-Seq_A2780_Human1.91484957
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89311900
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.80638270
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.80195465
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77646776
39FUS_26573619_Chip-Seq_HEK293_Human1.74165396
40RARB_27405468_Chip-Seq_BRAIN_Mouse1.71325512
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.71061597
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69686681
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.65008481
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63812940
45EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.63348761
46SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60645487
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.60575028
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.60522319
49ER_23166858_ChIP-Seq_MCF-7_Human1.55667711
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.54491429
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53229144
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.52457790
53PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52246170
54NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51740558
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48546945
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.46208393
57AR_25329375_ChIP-Seq_VCAP_Human1.44531432
58VDR_24787735_ChIP-Seq_THP-1_Human1.44131126
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.43278223
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39006228
61DROSHA_22980978_ChIP-Seq_HELA_Human1.38177714
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.36749482
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34692971
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34584318
65RNF2_27304074_Chip-Seq_NSC_Mouse1.34273920
66AR_21572438_ChIP-Seq_LNCaP_Human1.32211444
67ZNF274_21170338_ChIP-Seq_K562_Hela1.32161122
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.31187064
69CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.30256976
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30146734
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.29225243
72CJUN_26792858_Chip-Seq_BT549_Human1.29164631
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29042699
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.28541345
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.27944863
76JUN_21703547_ChIP-Seq_K562_Human1.26769594
77STAT3_23295773_ChIP-Seq_U87_Human1.25896175
78HTT_18923047_ChIP-ChIP_STHdh_Human1.25285150
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.24950590
80FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.24557281
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24332308
82FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.24262267
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22400094
84BCAT_22108803_ChIP-Seq_LS180_Human1.21331081
85* SOX2_20726797_ChIP-Seq_SW620_Human1.21143106
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.19610003
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.18725242
88ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18681251
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18129988
90* RUNX2_22187159_ChIP-Seq_PCA_Human1.17879047
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17702273
92TCF4_23295773_ChIP-Seq_U87_Human1.16501172
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.16375091
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16140131
95EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15499323
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15443143
97PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13470266
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12995550
99GATA2_21666600_ChIP-Seq_HMVEC_Human1.12055426
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11285964
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10305813
102P53_22387025_ChIP-Seq_ESCs_Mouse1.09591879
103IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07399263
104P300_18555785_Chip-Seq_ESCs_Mouse1.06724500
105CMYC_18555785_Chip-Seq_ESCs_Mouse1.06629640
106PU1_27457419_Chip-Seq_LIVER_Mouse1.06424287
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06069250
108NANOG_19829295_ChIP-Seq_ESCs_Human1.05965553
109SOX2_19829295_ChIP-Seq_ESCs_Human1.05965553
110FLI1_27457419_Chip-Seq_LIVER_Mouse1.05658418
111MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05160523
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05018592
113NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04896786
114NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04896786
115CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04134773
116KDM2B_26808549_Chip-Seq_REH_Human1.03859904
117E2F1_18555785_Chip-Seq_ESCs_Mouse1.02955928
118NMYC_18555785_Chip-Seq_ESCs_Mouse1.02877441
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02753073
120IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02152449
121P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01829051
122TFEB_21752829_ChIP-Seq_HELA_Human1.01825867
123FLI1_21867929_ChIP-Seq_TH2_Mouse1.01033598
124SOX2_18555785_Chip-Seq_ESCs_Mouse1.00740751
125FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00518724
126PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00439124
127NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00032690
128STAT3_18555785_Chip-Seq_ESCs_Mouse0.99676733
129SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99526556
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99421087
131RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98973834
132TAL1_26923725_Chip-Seq_HPCs_Mouse0.97908593
133ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97783827
134CDX2_22108803_ChIP-Seq_LS180_Human0.97183030
135TP53_18474530_ChIP-ChIP_U2OS_Human0.96756922
136SMAD1_18555785_Chip-Seq_ESCs_Mouse0.96568714
137TRIM28_21343339_ChIP-Seq_HEK293_Human0.96122396
138REST_19997604_ChIP-ChIP_NEURONS_Mouse0.95690117
139IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95354653
140CBP_20019798_ChIP-Seq_JUKART_Human0.95354653
141STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.94443429
142CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.94103340
143CTCF_18555785_Chip-Seq_ESCs_Mouse0.93933089
144SMAD4_21741376_ChIP-Seq_EPCs_Human0.93804030
145EWS_26573619_Chip-Seq_HEK293_Human0.93574434
146RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93545495
147MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93501440
148SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93443099

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.93432990
2MP0004859_abnormal_synaptic_plasticity3.92409729
3MP0003635_abnormal_synaptic_transmissio3.44295149
4MP0009046_muscle_twitch3.29669084
5MP0002064_seizures3.20403954
6MP0009745_abnormal_behavioral_response3.17436469
7MP0006082_CNS_inflammation3.10179752
8MP0004270_analgesia3.01181180
9MP0006054_spinal_hemorrhage3.00094753
10MP0001968_abnormal_touch/_nociception2.82194897
11MP0002063_abnormal_learning/memory/cond2.78591677
12MP0002572_abnormal_emotion/affect_behav2.69091197
13MP0002736_abnormal_nociception_after2.66539649
14MP0002272_abnormal_nervous_system2.62291080
15MP0009840_abnormal_foam_cell2.58176617
16MP0002734_abnormal_mechanical_nocicepti2.55643649
17MP0001501_abnormal_sleep_pattern2.51038320
18MP0001529_abnormal_vocalization2.42959659
19MP0002735_abnormal_chemical_nociception2.41952250
20MP0003724_increased_susceptibility_to2.36478112
21MP0009780_abnormal_chondrocyte_physiolo2.27273506
22MP0010386_abnormal_urinary_bladder2.25337045
23MP0003183_abnormal_peptide_metabolism2.24180077
24MP0001486_abnormal_startle_reflex2.20314557
25MP0006276_abnormal_autonomic_nervous2.18710472
26MP0003075_altered_response_to2.18406428
27MP0001440_abnormal_grooming_behavior2.16680049
28MP0002254_reproductive_system_inflammat2.15318991
29MP0005646_abnormal_pituitary_gland2.14722854
30MP0001970_abnormal_pain_threshold2.11311010
31MP0002733_abnormal_thermal_nociception2.07734759
32MP0002822_catalepsy2.06301643
33MP0003303_peritoneal_inflammation2.03964628
34MP0001905_abnormal_dopamine_level2.03920280
35MP0002067_abnormal_sensory_capabilities2.00860154
36MP0002139_abnormal_hepatobiliary_system1.96103741
37MP0000343_altered_response_to1.87584266
38MP0004043_abnormal_pH_regulation1.82822515
39MP0003329_amyloid_beta_deposits1.82645944
40MP0002837_dystrophic_cardiac_calcinosis1.80830333
41MP0000013_abnormal_adipose_tissue1.79955929
42MP0002876_abnormal_thyroid_physiology1.77069646
43MP0004142_abnormal_muscle_tone1.75480669
44MP0005423_abnormal_somatic_nervous1.74018287
45MP0001984_abnormal_olfaction1.73913136
46MP0005386_behavior/neurological_phenoty1.73616548
47MP0004924_abnormal_behavior1.73616548
48MP0002909_abnormal_adrenal_gland1.72571380
49MP0003191_abnormal_cellular_cholesterol1.72277283
50MP0001542_abnormal_bone_strength1.71410104
51MP0001188_hyperpigmentation1.65997604
52MP0002148_abnormal_hypersensitivity_rea1.65186753
53MP0001986_abnormal_taste_sensitivity1.61834337
54MP0003879_abnormal_hair_cell1.60769039
55MP0010234_abnormal_vibrissa_follicle1.60277749
56MP0003122_maternal_imprinting1.59055207
57MP0009785_altered_susceptibility_to1.58707877
58MP0005167_abnormal_blood-brain_barrier1.57581053
59MP0005645_abnormal_hypothalamus_physiol1.57101934
60MP0000569_abnormal_digit_pigmentation1.52876237
61MP0002295_abnormal_pulmonary_circulatio1.50779609
62MP0008438_abnormal_cutaneous_collagen1.50555115
63MP0002557_abnormal_social/conspecific_i1.48425872
64MP0002419_abnormal_innate_immunity1.43977803
65MP0003300_gastrointestinal_ulcer1.43905076
66MP0005379_endocrine/exocrine_gland_phen1.42481724
67MP0002184_abnormal_innervation1.41559548
68MP0008569_lethality_at_weaning1.38530897
69MP0001533_abnormal_skeleton_physiology1.37893732
70MP0001502_abnormal_circadian_rhythm1.36463113
71MP0005171_absent_coat_pigmentation1.34078086
72MP0002066_abnormal_motor_capabilities/c1.30172043
73MP0003011_delayed_dark_adaptation1.29221616
74MP0003633_abnormal_nervous_system1.24540143
75MP0004811_abnormal_neuron_physiology1.22549546
76MP0001756_abnormal_urination1.21199202
77MP0000955_abnormal_spinal_cord1.19469220
78MP0002229_neurodegeneration1.19318664
79MP0000778_abnormal_nervous_system1.19290295
80MP0003172_abnormal_lysosome_physiology1.18637967
81MP0002882_abnormal_neuron_morphology1.15728074
82MP0004019_abnormal_vitamin_homeostasis1.15005109
83MP0004510_myositis1.14838363
84MP0005166_decreased_susceptibility_to1.14684762
85MP0003436_decreased_susceptibility_to1.14021872
86MP0005535_abnormal_body_temperature1.12189540
87MP0009764_decreased_sensitivity_to1.12022599
88MP0005165_increased_susceptibility_to1.11707343
89MP0003787_abnormal_imprinting1.11384682
90MP0000920_abnormal_myelination1.09616104
91MP0000604_amyloidosis1.09237633
92MP0002638_abnormal_pupillary_reflex1.08256657
93MP0003631_nervous_system_phenotype1.07172847
94MP0002998_abnormal_bone_remodeling1.06738094
95MP0003634_abnormal_glial_cell1.05580656
96MP0005464_abnormal_platelet_physiology1.04549580
97MP0005058_abnormal_lysosome_morphology1.04351378
98MP0001664_abnormal_digestion1.03424492
99MP0003195_calcinosis1.03356537
100MP0003279_aneurysm1.02307707
101MP0005551_abnormal_eye_electrophysiolog1.01710769
102MP0004742_abnormal_vestibular_system1.01524397
103MP0001963_abnormal_hearing_physiology0.99019541
104MP0005000_abnormal_immune_tolerance0.98583358
105MP0010329_abnormal_lipoprotein_level0.98378600
106MP0005671_abnormal_response_to0.97635611
107MP0005164_abnormal_response_to0.97150770
108MP0002163_abnormal_gland_morphology0.96897678
109MP0005365_abnormal_bile_salt0.96857881
110MP0003690_abnormal_glial_cell0.96274497
111MP0004883_abnormal_blood_vessel0.94204668
112MP0001845_abnormal_inflammatory_respons0.94180972
113MP0002693_abnormal_pancreas_physiology0.93659522
114MP0003186_abnormal_redox_activity0.93497472
115MP0002090_abnormal_vision0.93084382
116MP0008260_abnormal_autophagy0.92982437
117MP0008469_abnormal_protein_level0.92660183
118MP0004858_abnormal_nervous_system0.92050017
119MP0005248_abnormal_Harderian_gland0.90117916
120MP0008872_abnormal_physiological_respon0.87678420
121MP0001790_abnormal_immune_system0.85945818
122MP0005387_immune_system_phenotype0.85945818
123MP0003795_abnormal_bone_structure0.85616891
124MP0002069_abnormal_eating/drinking_beha0.85394717
125MP0001853_heart_inflammation0.85227585
126MP0000631_abnormal_neuroendocrine_gland0.83890675
127MP0002896_abnormal_bone_mineralization0.83716048
128MP0004885_abnormal_endolymph0.83349166
129MP0001835_abnormal_antigen_presentation0.83052165
130MP0005257_abnormal_intraocular_pressure0.82956459
131MP0001958_emphysema0.82672711
132MP0005367_renal/urinary_system_phenotyp0.81150068
133MP0000516_abnormal_urinary_system0.81150068
134MP0005025_abnormal_response_to0.80348866
135MP0003656_abnormal_erythrocyte_physiolo0.79573045
136MP0003632_abnormal_nervous_system0.78270466
137MP0005310_abnormal_salivary_gland0.76160946
138MP0000465_gastrointestinal_hemorrhage0.74823368
139MP0001765_abnormal_ion_homeostasis0.74276566
140MP0006072_abnormal_retinal_apoptosis0.69332302
141MP0002152_abnormal_brain_morphology0.69251328
142MP0008874_decreased_physiological_sensi0.68480952
143MP0000681_abnormal_thyroid_gland0.68463473
144MP0001485_abnormal_pinna_reflex0.65973112
145MP0008004_abnormal_stomach_pH0.62673839
146MP0001177_atelectasis0.60448349
147MP0002752_abnormal_somatic_nervous0.59464100
148MP0004085_abnormal_heartbeat0.57805712
149MP0000230_abnormal_systemic_arterial0.55802593
150MP0002078_abnormal_glucose_homeostasis0.54493366
151MP0005253_abnormal_eye_physiology0.54004757
152MP0000026_abnormal_inner_ear0.53991403
153MP0000538_abnormal_urinary_bladder0.52447675
154MP0006036_abnormal_mitochondrial_physio0.51033499
155MP0005394_taste/olfaction_phenotype0.50471115

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.77725364
2Vacuolated lymphocytes (HP:0001922)5.83876806
3Atonic seizures (HP:0010819)5.31929548
4Epileptic encephalopathy (HP:0200134)4.73337629
5Visual hallucinations (HP:0002367)4.37688627
6Febrile seizures (HP:0002373)4.31565220
7Focal seizures (HP:0007359)4.28945947
8Abnormality of glycosaminoglycan metabolism (HP:0004371)4.15157248
9Abnormality of mucopolysaccharide metabolism (HP:0011020)4.15157248
10Abnormality of polysaccharide metabolism (HP:0011012)4.15157248
11Absence seizures (HP:0002121)4.08320357
12Mucopolysacchariduria (HP:0008155)4.01246314
13Urinary glycosaminoglycan excretion (HP:0003541)4.01246314
14Pheochromocytoma (HP:0002666)4.00478763
15Acute necrotizing encephalopathy (HP:0006965)3.93998994
16Neuroendocrine neoplasm (HP:0100634)3.87970241
17Loss of speech (HP:0002371)3.87613850
18Hyperventilation (HP:0002883)3.87247400
19Dialeptic seizures (HP:0011146)3.87176196
20Abnormal mitochondria in muscle tissue (HP:0008316)3.79361854
21Myokymia (HP:0002411)3.78273888
22Disinhibition (HP:0000734)3.52377739
23Progressive macrocephaly (HP:0004481)3.42164118
24Progressive neurologic deterioration (HP:0002344)3.36539852
25Mitochondrial inheritance (HP:0001427)3.26880615
26Abnormal hair whorl (HP:0010721)3.19519220
27Abnormality of macrophages (HP:0004311)3.19487311
28Limb dystonia (HP:0002451)3.04140625
29Hematochezia (HP:0002573)3.00393816
30Acute encephalopathy (HP:0006846)2.99774902
31Progressive cerebellar ataxia (HP:0002073)2.99522879
32Hypothermia (HP:0002045)2.94177761
33* Generalized tonic-clonic seizures (HP:0002069)2.92279960
34Gait imbalance (HP:0002141)2.91209647
35Increased CSF protein (HP:0002922)2.86803804
36Polyphagia (HP:0002591)2.85237974
37Systemic lupus erythematosus (HP:0002725)2.83593068
38Medial flaring of the eyebrow (HP:0010747)2.83274127
39Nuclear cataract (HP:0100018)2.82221498
40Epileptiform EEG discharges (HP:0011182)2.73783591
41Increased CSF lactate (HP:0002490)2.73348088
42Failure to thrive in infancy (HP:0001531)2.72844125
43Congenital primary aphakia (HP:0007707)2.71528392
44Neurofibrillary tangles (HP:0002185)2.70413485
45Cerebral inclusion bodies (HP:0100314)2.64658061
46Supranuclear gaze palsy (HP:0000605)2.63380174
47Diplopia (HP:0000651)2.62036836
48Abnormality of binocular vision (HP:0011514)2.62036836
49Abnormal eating behavior (HP:0100738)2.61907167
50Nephrogenic diabetes insipidus (HP:0009806)2.60472908
51Apathy (HP:0000741)2.59915676
52Diminished motivation (HP:0000745)2.58381670
53Poor suck (HP:0002033)2.54912364
54EEG with generalized epileptiform discharges (HP:0011198)2.54318583
55Hepatocellular necrosis (HP:0001404)2.52919433
56Progressive inability to walk (HP:0002505)2.51832266
57Broad-based gait (HP:0002136)2.51113056
58Truncal ataxia (HP:0002078)2.45940745
59Anxiety (HP:0000739)2.44598870
60Hypsarrhythmia (HP:0002521)2.37285902
61Tongue fasciculations (HP:0001308)2.34216305
62Stomatitis (HP:0010280)2.32542297
63Increased neuronal autofluorescent lipopigment (HP:0002074)2.29203753
64Intention tremor (HP:0002080)2.24679098
65Akinesia (HP:0002304)2.23078840
66Gaze-evoked nystagmus (HP:0000640)2.21834081
67Optic disc pallor (HP:0000543)2.21550056
68Increased cerebral lipofuscin (HP:0011813)2.20538024
69Vaginal atresia (HP:0000148)2.20481345
70Axonal loss (HP:0003447)2.20286226
71Genital tract atresia (HP:0001827)2.19840597
72Increased serum pyruvate (HP:0003542)2.19400322
73Abnormality of glycolysis (HP:0004366)2.19400322
74Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.19165884
75Prolonged neonatal jaundice (HP:0006579)2.18044860
76Depression (HP:0000716)2.17661455
77Amblyopia (HP:0000646)2.17517237
78Inability to walk (HP:0002540)2.16705690
79Postural tremor (HP:0002174)2.15399724
80Inappropriate behavior (HP:0000719)2.15187964
81Amyloidosis (HP:0011034)2.15060296
82Blue irides (HP:0000635)2.13779043
83Excessive salivation (HP:0003781)2.13336120
84Drooling (HP:0002307)2.13336120
85Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.13241275
86Oligomenorrhea (HP:0000876)2.12649289
87Agnosia (HP:0010524)2.11365478
88Metaphyseal irregularity (HP:0003025)2.10156319
89Leukodystrophy (HP:0002415)2.08296198
90Abnormality of aromatic amino acid family metabolism (HP:0004338)2.07774605
91Agitation (HP:0000713)2.07667309
92Delusions (HP:0000746)2.07148036
93Abnormality of calcium-phosphate metabolism (HP:0100530)2.06645676
94Recurrent bacterial skin infections (HP:0005406)2.05659415
95Protruding tongue (HP:0010808)2.05213845
96Generalized myoclonic seizures (HP:0002123)2.02408523
97Dysmetria (HP:0001310)2.01077342
98Abnormality of glycolipid metabolism (HP:0010969)1.99907426
99Abnormality of liposaccharide metabolism (HP:0010968)1.99907426
100Abnormality of glycosphingolipid metabolism (HP:0004343)1.99907426
101Neuronal loss in central nervous system (HP:0002529)1.99438007
102Degeneration of the lateral corticospinal tracts (HP:0002314)1.99119105
103Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.99119105
104Retinal dysplasia (HP:0007973)1.98872755
105Psychosis (HP:0000709)1.98809304
106Bone cyst (HP:0012062)1.98567362
107Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.98229509
108Muscle fibrillation (HP:0010546)1.97912766
109Recurrent abscess formation (HP:0002722)1.97879164
110Dysostosis multiplex (HP:0000943)1.97237869
111Tetraparesis (HP:0002273)1.94859265
112Mutism (HP:0002300)1.94778035
113Retinal atrophy (HP:0001105)1.93591965
114Zonular cataract (HP:0010920)1.93492917
115Poor eye contact (HP:0000817)1.93375300
116Esotropia (HP:0000565)1.92288175
117Cardiomegaly (HP:0001640)1.90983973
118Eczematoid dermatitis (HP:0000976)1.90809288
119Episodic fever (HP:0001954)1.90189562
120Specific learning disability (HP:0001328)1.89825368
121Petechiae (HP:0000967)1.89705725
122Hepatic necrosis (HP:0002605)1.89536919
123Myoclonus (HP:0001336)1.87870690
124Clumsiness (HP:0002312)1.87002049
125Action tremor (HP:0002345)1.86954998
126Ankle clonus (HP:0011448)1.86730596
127Dementia (HP:0000726)1.86438267
128Neoplasm of the peripheral nervous system (HP:0100007)1.86260499
129Mitral stenosis (HP:0001718)1.86023594
130Respiratory failure (HP:0002878)1.85574598
131Cortical visual impairment (HP:0100704)1.84346741
132Abnormality of the vasculature of the conjunctiva (HP:0008054)1.84117009
133Absent speech (HP:0001344)1.83186160
134Congenital sensorineural hearing impairment (HP:0008527)1.83185351
135Poor coordination (HP:0002370)1.82890104
136Hepatosplenomegaly (HP:0001433)1.82569119
137Abnormality of the basal ganglia (HP:0002134)1.81954219
138Hypokinesia (HP:0002375)1.81839278
139Hemiparesis (HP:0001269)1.81441024
140Dysautonomia (HP:0002459)1.81154022
141Diminished movement (HP:0002374)1.81070727
142Symptomatic seizures (HP:0011145)1.80774432
143Global brain atrophy (HP:0002283)1.80520489
144X-linked dominant inheritance (HP:0001423)1.80253201
145Basal ganglia calcification (HP:0002135)1.79306932
146Impaired vibration sensation in the lower limbs (HP:0002166)1.79085919
147J-shaped sella turcica (HP:0002680)1.78825112
148Dysdiadochokinesis (HP:0002075)1.78335800
149Cerebral hemorrhage (HP:0001342)1.77951680
150Spastic gait (HP:0002064)1.75953059
151Fetal akinesia sequence (HP:0001989)1.75667231
152Muscular hypotonia of the trunk (HP:0008936)1.74976921
153Hypoglycemic coma (HP:0001325)1.73139189
154Sensorimotor neuropathy (HP:0007141)1.72160334
155Hypoglycemic seizures (HP:0002173)1.70690764
156Tetany (HP:0001281)1.70497892
157Glomerulonephritis (HP:0000099)1.69662774
158Protuberant abdomen (HP:0001538)1.68715473
159Purpura (HP:0000979)1.67283907
160Xanthomatosis (HP:0000991)1.67202326
161Albinism (HP:0001022)1.62652725
162Myocardial infarction (HP:0001658)1.62645636
163Abnormal neuron morphology (HP:0012757)1.62606974
164Abnormality of the motor neurons (HP:0002450)1.62606974
165Memory impairment (HP:0002354)1.61674684
166Recurrent gram-negative bacterial infections (HP:0005420)1.61323922
167Ketoacidosis (HP:0001993)1.58593854
168Poor head control (HP:0002421)1.54347158
169Delayed gross motor development (HP:0002194)1.54122519
170Hyperglycemia (HP:0003074)1.51707331
171Atrophy/Degeneration involving motor neurons (HP:0007373)1.51630650
172Degeneration of anterior horn cells (HP:0002398)1.50365633
173Abnormality of the anterior horn cell (HP:0006802)1.50365633
174Restlessness (HP:0000711)1.49043145
175Focal dystonia (HP:0004373)1.47965127

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.87304336
2MAP3K123.84653046
3NTRK33.29758962
4MAP2K73.13531937
5MAP3K42.75673390
6RIPK42.64031103
7TESK12.63362098
8MAP4K22.59047795
9CDK192.40283443
10PLK22.26998070
11EPHA42.26921679
12ARAF2.15309446
13OXSR12.14811986
14MAP3K92.06931351
15GRK52.01901651
16AKT31.85556987
17MINK11.80648845
18NME11.73086361
19ACVR1B1.72656295
20TRIM281.70005697
21DAPK11.67784814
22MAP2K41.64859274
23DAPK21.62262511
24TSSK61.59640286
25BMPR21.58853300
26NTRK11.57551242
27CSNK1G11.57524417
28CAMKK21.57052951
29MARK11.54781024
30TGFBR21.51894882
31EPHA31.44238509
32BMPR1B1.43237732
33DDR21.40630226
34INSRR1.39880615
35PNCK1.34113397
36GRK71.33677684
37CSNK1A1L1.31515701
38MAP3K31.31272286
39CCNB11.28826319
40PINK11.27865203
41PRPF4B1.25222112
42TNIK1.24695447
43NTRK21.21107495
44TYK21.20545831
45CAMK2B1.19072623
46CAMK2A1.17233484
47MAP3K141.16369794
48ABL21.15925076
49CDK51.15474565
50BRAF1.14833339
51PRKCG1.12721600
52BCR1.09466889
53STK391.09433523
54JAK11.07718032
55PRKCE1.06763569
56SIK31.05191364
57MAP3K21.05070399
58FES1.02997064
59ADRBK21.02426846
60MAPK131.01207723
61BLK0.97164820
62UHMK10.94478564
63TBK10.92103500
64GRK10.92053946
65IRAK30.90570525
66FGR0.88873052
67PIM20.88736274
68WNK40.88165630
69MAPKAPK50.87937999
70TAOK30.87826563
71SGK4940.87637530
72SGK2230.87637530
73PHKG20.87147238
74PHKG10.87147238
75CAMK2D0.86426861
76STK160.82217448
77MST40.81282104
78KSR20.80689457
79PTK2B0.79966138
80CSNK1G20.76790020
81ADRBK10.76205965
82MATK0.75532765
83MAP2K60.75019942
84MOS0.74947843
85NEK90.73283268
86CDK140.72075921
87PDK30.72075839
88PDK40.72075839
89MAP3K130.71129200
90IKBKB0.70819928
91WNK30.69820796
92CDK180.69135509
93PDK20.67958015
94RPS6KA40.66947195
95PAK60.66161392
96MAP3K50.65145724
97CAMK2G0.65055032
98MYLK0.64855110
99CDK80.63980643
100CDK150.62734888
101EPHB10.61548011
102CSF1R0.61280195
103GSK3A0.60513063
104SGK20.59623052
105MAPK150.58940278
106BCKDK0.58441373
107DYRK1A0.58436129
108MAP3K10.57633275
109SCYL20.57632559
110FGFR20.57578678
111CAMKK10.57544291
112CSNK1G30.57533808
113MAP3K110.54869060
114TESK20.54472940
115MUSK0.52846012
116TXK0.50573464
117CDK11A0.50466997
118KSR10.48606264
119FGFR30.48426776
120TAOK10.48366895
121ABL10.48237445
122STK38L0.47281833
123ROCK20.45673623
124FER0.45253418
125JAK20.44840603
126LIMK10.44153622
127CSK0.43973502
128PAK40.43933762
129DAPK30.43723002
130EIF2AK30.43550604
131IRAK20.43080260
132NLK0.42518136
133LYN0.41385414
134FRK0.41171648
135PRKCH0.40513804
136SGK10.40402271
137PRKACA0.39940711
138NEK60.38701752
139PDPK10.38111496
140YES10.37474106
141SIK20.36965346
142ERBB40.36169542
143PAK30.36013238
144ERBB30.35560023
145CSNK1A10.35328882
146MAP2K10.34344940
147PRKCA0.33888739
148RET0.33521988
149GRK60.33272365

Predicted pathways (KEGG)

RankGene SetZ-score
1Collecting duct acid secretion_Homo sapiens_hsa049664.20108230
2Synaptic vesicle cycle_Homo sapiens_hsa047214.06689936
3Nicotine addiction_Homo sapiens_hsa050333.50257627
4Oxidative phosphorylation_Homo sapiens_hsa001903.18325267
5Vibrio cholerae infection_Homo sapiens_hsa051103.05141095
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.50224387
7GABAergic synapse_Homo sapiens_hsa047272.43794121
8Morphine addiction_Homo sapiens_hsa050322.21014031
9Parkinsons disease_Homo sapiens_hsa050122.16415679
10Amphetamine addiction_Homo sapiens_hsa050312.07408379
11Taste transduction_Homo sapiens_hsa047422.01816579
12Circadian entrainment_Homo sapiens_hsa047131.98142884
13Alzheimers disease_Homo sapiens_hsa050101.97010829
14Long-term potentiation_Homo sapiens_hsa047201.94423411
15Protein export_Homo sapiens_hsa030601.92494951
16Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.89476437
17Insulin secretion_Homo sapiens_hsa049111.88559409
18Olfactory transduction_Homo sapiens_hsa047401.86828493
19Rheumatoid arthritis_Homo sapiens_hsa053231.85826758
20Dopaminergic synapse_Homo sapiens_hsa047281.82281187
21Serotonergic synapse_Homo sapiens_hsa047261.81347460
22Glutamatergic synapse_Homo sapiens_hsa047241.77757314
23Cocaine addiction_Homo sapiens_hsa050301.55405210
24Phagosome_Homo sapiens_hsa041451.51030300
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49002256
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45888634
27Salivary secretion_Homo sapiens_hsa049701.44553456
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44447652
29Type I diabetes mellitus_Homo sapiens_hsa049401.43702198
30Long-term depression_Homo sapiens_hsa047301.41213926
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.40873674
32Pertussis_Homo sapiens_hsa051331.38075107
33Renin secretion_Homo sapiens_hsa049241.35199587
34Huntingtons disease_Homo sapiens_hsa050161.34710307
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.34019721
36Cholinergic synapse_Homo sapiens_hsa047251.31515250
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.28735785
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.27525090
39Staphylococcus aureus infection_Homo sapiens_hsa051501.24831934
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.24518042
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21767574
42Legionellosis_Homo sapiens_hsa051341.17677063
43Lysosome_Homo sapiens_hsa041421.17138761
44Calcium signaling pathway_Homo sapiens_hsa040201.15519415
45Gastric acid secretion_Homo sapiens_hsa049711.15229551
46SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14264603
47Sulfur metabolism_Homo sapiens_hsa009201.12089550
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09749637
49Osteoclast differentiation_Homo sapiens_hsa043801.07209502
50Cardiac muscle contraction_Homo sapiens_hsa042601.06619930
51Salmonella infection_Homo sapiens_hsa051321.06150972
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.05331140
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.02139269
54Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96705314
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90520883
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89518393
57Steroid biosynthesis_Homo sapiens_hsa001000.88250757
58Oxytocin signaling pathway_Homo sapiens_hsa049210.84666504
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84401542
60Phototransduction_Homo sapiens_hsa047440.83635823
61Type II diabetes mellitus_Homo sapiens_hsa049300.83397604
62Folate biosynthesis_Homo sapiens_hsa007900.81548594
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78379669
64Regulation of autophagy_Homo sapiens_hsa041400.78028385
65Malaria_Homo sapiens_hsa051440.77170405
66Gap junction_Homo sapiens_hsa045400.76998098
67Tryptophan metabolism_Homo sapiens_hsa003800.76717442
68Pancreatic secretion_Homo sapiens_hsa049720.71231153
69Glutathione metabolism_Homo sapiens_hsa004800.69927480
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69905624
71Peroxisome_Homo sapiens_hsa041460.68887590
72cAMP signaling pathway_Homo sapiens_hsa040240.68685505
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67682496
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66505908
75Leishmaniasis_Homo sapiens_hsa051400.66252461
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65833936
77GnRH signaling pathway_Homo sapiens_hsa049120.65545566
78Asthma_Homo sapiens_hsa053100.65510040
79Shigellosis_Homo sapiens_hsa051310.65304546
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64083142
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62651060
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.62560522
83Complement and coagulation cascades_Homo sapiens_hsa046100.61384793
84Sphingolipid metabolism_Homo sapiens_hsa006000.60969014
85Vitamin B6 metabolism_Homo sapiens_hsa007500.60814099
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60594163
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60311348
88Fatty acid elongation_Homo sapiens_hsa000620.58089507
89Other glycan degradation_Homo sapiens_hsa005110.55930580
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54682941
91Estrogen signaling pathway_Homo sapiens_hsa049150.54510692
92Thyroid hormone synthesis_Homo sapiens_hsa049180.53108828
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51668287
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50916460
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50398845
96Antigen processing and presentation_Homo sapiens_hsa046120.49695129
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48654931
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48603776
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48558530
100beta-Alanine metabolism_Homo sapiens_hsa004100.48102739
101Hematopoietic cell lineage_Homo sapiens_hsa046400.47221177
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47174600
103Ether lipid metabolism_Homo sapiens_hsa005650.45143803
104Galactose metabolism_Homo sapiens_hsa000520.43597680
105Amoebiasis_Homo sapiens_hsa051460.43117403
106Proteasome_Homo sapiens_hsa030500.42783556
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42374419
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42268376
109African trypanosomiasis_Homo sapiens_hsa051430.40334640
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39833249
111PPAR signaling pathway_Homo sapiens_hsa033200.39577229
112Alcoholism_Homo sapiens_hsa050340.39549409
113ErbB signaling pathway_Homo sapiens_hsa040120.38992077
114Fatty acid metabolism_Homo sapiens_hsa012120.38875195
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37849241
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37588546
117Axon guidance_Homo sapiens_hsa043600.37548399
118Allograft rejection_Homo sapiens_hsa053300.37392947
119N-Glycan biosynthesis_Homo sapiens_hsa005100.36864732
120TNF signaling pathway_Homo sapiens_hsa046680.35815629
121Melanogenesis_Homo sapiens_hsa049160.35486307
122Pyruvate metabolism_Homo sapiens_hsa006200.34721807
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34430641
124Chemokine signaling pathway_Homo sapiens_hsa040620.32881363
125Tuberculosis_Homo sapiens_hsa051520.32758555
126Graft-versus-host disease_Homo sapiens_hsa053320.32607477
127Inositol phosphate metabolism_Homo sapiens_hsa005620.32173670
128Circadian rhythm_Homo sapiens_hsa047100.30606384
129Butanoate metabolism_Homo sapiens_hsa006500.30149855
130Prion diseases_Homo sapiens_hsa050200.29478803
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.28333211
132MAPK signaling pathway_Homo sapiens_hsa040100.27975179
133Mineral absorption_Homo sapiens_hsa049780.27956602
134Ras signaling pathway_Homo sapiens_hsa040140.27050640
135Glioma_Homo sapiens_hsa052140.26353719
136Glycosaminoglycan degradation_Homo sapiens_hsa005310.25371321
137Endocytosis_Homo sapiens_hsa041440.22798220
138Oocyte meiosis_Homo sapiens_hsa041140.19251724
139Glucagon signaling pathway_Homo sapiens_hsa049220.17884997
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.15400989

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