ATP5SL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine metabolic process (GO:0006553)4.84267842
2lysine catabolic process (GO:0006554)4.84267842
3serine family amino acid catabolic process (GO:0009071)4.76980862
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.75130069
5L-phenylalanine metabolic process (GO:0006558)4.75130069
6glycine metabolic process (GO:0006544)4.69713724
7chaperone-mediated protein transport (GO:0072321)4.69582846
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.63658218
9NADH metabolic process (GO:0006734)4.56402002
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.52288904
11L-phenylalanine catabolic process (GO:0006559)4.52288904
12amino-acid betaine metabolic process (GO:0006577)4.50172176
13tricarboxylic acid cycle (GO:0006099)4.48833005
14oxaloacetate metabolic process (GO:0006107)4.46934338
15DNA deamination (GO:0045006)4.46265882
16glyoxylate metabolic process (GO:0046487)4.44735436
172-oxoglutarate metabolic process (GO:0006103)4.42329494
18proteasome assembly (GO:0043248)4.35298959
19aromatic amino acid family catabolic process (GO:0009074)4.29141791
20aspartate family amino acid catabolic process (GO:0009068)4.24998799
21kynurenine metabolic process (GO:0070189)4.23547773
22oxidative phosphorylation (GO:0006119)4.16807986
23tryptophan catabolic process (GO:0006569)4.16182285
24indole-containing compound catabolic process (GO:0042436)4.16182285
25indolalkylamine catabolic process (GO:0046218)4.16182285
26fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.13446032
27protein complex biogenesis (GO:0070271)4.08896311
28serine family amino acid metabolic process (GO:0009069)4.00495653
29regulation of mitochondrial translation (GO:0070129)3.98289666
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.97940459
31NADH dehydrogenase complex assembly (GO:0010257)3.97940459
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.97940459
33carnitine metabolic process (GO:0009437)3.96092532
34energy coupled proton transport, down electrochemical gradient (GO:0015985)3.88130808
35ATP synthesis coupled proton transport (GO:0015986)3.88130808
36cysteine metabolic process (GO:0006534)3.86605121
37mitochondrial respiratory chain complex assembly (GO:0033108)3.85488665
38negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.85172314
39short-chain fatty acid metabolic process (GO:0046459)3.82336700
40succinate metabolic process (GO:0006105)3.81408272
41establishment of integrated proviral latency (GO:0075713)3.77832369
42cellular ketone body metabolic process (GO:0046950)3.75728375
43tryptophan metabolic process (GO:0006568)3.74356614
44DNA damage response, detection of DNA damage (GO:0042769)3.72656901
45protein deneddylation (GO:0000338)3.70538642
46alpha-amino acid catabolic process (GO:1901606)3.67804418
47ethanol oxidation (GO:0006069)3.65490885
48serine family amino acid biosynthetic process (GO:0009070)3.64479931
49cullin deneddylation (GO:0010388)3.64227240
50fatty acid beta-oxidation (GO:0006635)3.56182508
51branched-chain amino acid catabolic process (GO:0009083)3.54761980
52negative regulation of ligase activity (GO:0051352)3.54047580
53negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.54047580
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.53726865
55NAD metabolic process (GO:0019674)3.52615871
56regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.48775269
57positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.48700681
58bile acid biosynthetic process (GO:0006699)3.47852587
59peptidyl-histidine modification (GO:0018202)3.47831671
60cellular amino acid catabolic process (GO:0009063)3.47351813
61base-excision repair, AP site formation (GO:0006285)3.47316235
62triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.41859623
63tricarboxylic acid metabolic process (GO:0072350)3.41478407
64protein targeting to mitochondrion (GO:0006626)3.40155036
65respiratory chain complex IV assembly (GO:0008535)3.39116265
66L-methionine salvage (GO:0071267)3.37533461
67L-methionine biosynthetic process (GO:0071265)3.37533461
68amino acid salvage (GO:0043102)3.37533461
69branched-chain amino acid metabolic process (GO:0009081)3.37235757
70nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.37074807
71establishment of viral latency (GO:0019043)3.37041027
72valine metabolic process (GO:0006573)3.36914648
73acetyl-CoA metabolic process (GO:0006084)3.36243407
74regulation of cellular amino acid metabolic process (GO:0006521)3.35683726
75anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.35658552
76sulfur amino acid catabolic process (GO:0000098)3.34223398
77metallo-sulfur cluster assembly (GO:0031163)3.32031229
78iron-sulfur cluster assembly (GO:0016226)3.32031229
79mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.31516157
80pseudouridine synthesis (GO:0001522)3.31042215
81DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.29307399
82establishment of protein localization to mitochondrion (GO:0072655)3.27242497
83DNA strand elongation involved in DNA replication (GO:0006271)3.27034339
84signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.24830085
85signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.24830085
86signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.24830085
87fatty acid catabolic process (GO:0009062)3.24825261
88exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.24740448
89pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.23253887
90fatty acid oxidation (GO:0019395)3.21725689
91sulfur amino acid biosynthetic process (GO:0000097)3.21714584
92termination of RNA polymerase III transcription (GO:0006386)3.21538954
93transcription elongation from RNA polymerase III promoter (GO:0006385)3.21538954
94ubiquinone metabolic process (GO:0006743)3.21081985
95folic acid metabolic process (GO:0046655)3.21015663
96respiratory electron transport chain (GO:0022904)3.20669163
97signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.19942141
98intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.19942141
99aspartate family amino acid metabolic process (GO:0009066)3.19818457
100cytochrome complex assembly (GO:0017004)3.19786879
101carboxylic acid catabolic process (GO:0046395)3.19396198
102organic acid catabolic process (GO:0016054)3.19396198
103alpha-linolenic acid metabolic process (GO:0036109)3.19212715
104aromatic amino acid family metabolic process (GO:0009072)3.18784529
105drug catabolic process (GO:0042737)3.18125820
106histone arginine methylation (GO:0034969)3.15910483
107lipid oxidation (GO:0034440)3.14662686
108electron transport chain (GO:0022900)3.14250435
109purine nucleobase biosynthetic process (GO:0009113)3.14181087
110protein localization to mitochondrion (GO:0070585)3.13580105
111DNA double-strand break processing (GO:0000729)3.13414730
112signal transduction involved in cell cycle checkpoint (GO:0072395)3.13201624
113ketone body metabolic process (GO:1902224)3.13119521
114signal transduction involved in DNA integrity checkpoint (GO:0072401)3.12937248
115signal transduction involved in DNA damage checkpoint (GO:0072422)3.12937248
116regulation of acyl-CoA biosynthetic process (GO:0050812)3.12612683
117chromatin remodeling at centromere (GO:0031055)3.11775156
118monocarboxylic acid catabolic process (GO:0072329)3.11096741
119DNA strand elongation (GO:0022616)3.09132642
120fructose metabolic process (GO:0006000)3.08974165
121regulation of cofactor metabolic process (GO:0051193)3.07795965
122regulation of coenzyme metabolic process (GO:0051196)3.07795965
123positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.07761027
124glutamate metabolic process (GO:0006536)3.06323878
125ribosomal small subunit assembly (GO:0000028)3.06188124
126telomere maintenance via semi-conservative replication (GO:0032201)3.05880559
127dicarboxylic acid biosynthetic process (GO:0043650)3.04666267
128NAD biosynthetic process (GO:0009435)3.04014073
129gluconeogenesis (GO:0006094)3.03951714
130DNA strand renaturation (GO:0000733)3.03017332
131cellular modified amino acid catabolic process (GO:0042219)3.02021888
132hexose biosynthetic process (GO:0019319)3.01684240
133L-serine metabolic process (GO:0006563)3.00705725
134spliceosomal snRNP assembly (GO:0000387)3.00419643
135GTP biosynthetic process (GO:0006183)2.99595033
136homocysteine metabolic process (GO:0050667)2.99001915
137dicarboxylic acid metabolic process (GO:0043648)2.98940656
138peptidyl-arginine omega-N-methylation (GO:0035247)2.98631617
139urate metabolic process (GO:0046415)2.98286575
140urea metabolic process (GO:0019627)2.97456060
141urea cycle (GO:0000050)2.97456060
142nucleobase biosynthetic process (GO:0046112)2.95972194
143nitrogen cycle metabolic process (GO:0071941)2.95264514
144positive regulation of ligase activity (GO:0051351)2.91787013
145DNA replication checkpoint (GO:0000076)2.91247744
146exogenous drug catabolic process (GO:0042738)2.90173282
147mitochondrial RNA metabolic process (GO:0000959)2.90082090
148bile acid metabolic process (GO:0008206)2.89752374
149pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.87999986
150dicarboxylic acid catabolic process (GO:0043649)2.87078779
151protein neddylation (GO:0045116)2.87073326
152aerobic respiration (GO:0009060)2.86282281
153methionine metabolic process (GO:0006555)2.85974497
154biotin metabolic process (GO:0006768)2.85887194
155base-excision repair (GO:0006284)2.85662533
156negative regulation of fibrinolysis (GO:0051918)2.85518285
157UTP biosynthetic process (GO:0006228)2.84026525
158regulation of ubiquitin-protein transferase activity (GO:0051438)2.83507295
159replication fork processing (GO:0031297)2.82766041
160CENP-A containing nucleosome assembly (GO:0034080)2.82600595
161cellular component biogenesis (GO:0044085)2.82327039
162sulfur amino acid metabolic process (GO:0000096)2.81022384
163pyrimidine nucleoside catabolic process (GO:0046135)2.80760030
164ubiquinone biosynthetic process (GO:0006744)2.80580864
165quinone biosynthetic process (GO:1901663)2.80580864
166mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.80209258
167tRNA processing (GO:0008033)2.80054982
168tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.79656357
169RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.79656357
170protein-cofactor linkage (GO:0018065)2.79085069
171nicotinamide nucleotide biosynthetic process (GO:0019359)2.78599182
172pyridine nucleotide biosynthetic process (GO:0019363)2.78599182
173transcription-coupled nucleotide-excision repair (GO:0006283)2.78449198
174indolalkylamine metabolic process (GO:0006586)2.78422625
175CTP biosynthetic process (GO:0006241)2.76397728
176CTP metabolic process (GO:0046036)2.76397728
177coenzyme catabolic process (GO:0009109)2.75061707
178monosaccharide biosynthetic process (GO:0046364)2.73379755
179guanosine-containing compound biosynthetic process (GO:1901070)2.73195069
180tRNA metabolic process (GO:0006399)2.72989534
181regulation of ligase activity (GO:0051340)2.71055270
182pyrimidine nucleotide catabolic process (GO:0006244)2.70921253
183small molecule catabolic process (GO:0044282)2.70386860
184L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.70131084
185pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.70032380
186ribosome biogenesis (GO:0042254)2.69956127
187translation (GO:0006412)2.68795591
188negative regulation of sterol transport (GO:0032372)2.68453457
189negative regulation of cholesterol transport (GO:0032375)2.68453457
190pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.66442545
191UTP metabolic process (GO:0046051)2.66363764
192purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.66085830
193purine nucleoside triphosphate biosynthetic process (GO:0009145)2.65915371
194positive regulation of mitochondrial fission (GO:0090141)2.65422691
195formation of translation preinitiation complex (GO:0001731)2.65377748

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.59455946
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.55377131
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.38448816
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.07300927
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.01083976
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86946793
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.84602818
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.84572786
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.60347789
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.49916548
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47673627
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.45588853
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44145932
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.39046807
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.36247265
16EGR1_23403033_ChIP-Seq_LIVER_Mouse2.33800832
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.31164161
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.30663401
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.19114479
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.13649377
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07596630
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.06576388
23ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.04098969
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.03507784
25MYC_22102868_ChIP-Seq_BL_Human1.91991987
26MYC_19030024_ChIP-ChIP_MESCs_Mouse1.91965872
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.90940520
28CIITA_25753668_ChIP-Seq_RAJI_Human1.87379105
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.86654024
30* YY1_21170310_ChIP-Seq_MESCs_Mouse1.84975279
31XRN2_22483619_ChIP-Seq_HELA_Human1.84801847
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.84649682
33LXR_22158963_ChIP-Seq_LIVER_Mouse1.80425228
34GABP_19822575_ChIP-Seq_HepG2_Human1.79984852
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72870746
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72290671
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72097862
38* FOXP3_21729870_ChIP-Seq_TREG_Human1.68478205
39TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67217662
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60524181
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59760829
42* VDR_23849224_ChIP-Seq_CD4+_Human1.59280289
43ELK1_19687146_ChIP-ChIP_HELA_Human1.57286069
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.57151957
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55882729
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55882367
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54418482
48MYC_18940864_ChIP-ChIP_HL60_Human1.54389845
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53801918
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.52827637
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52179141
52NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.51290468
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49649312
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48975421
55E2F7_22180533_ChIP-Seq_HELA_Human1.48896922
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46207651
57DCP1A_22483619_ChIP-Seq_HELA_Human1.45535871
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41362449
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39103949
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.37632165
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35740824
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35529954
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32300861
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.32142103
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30912784
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30500947
67SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.29199557
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28911966
69FOXP1_21924763_ChIP-Seq_HESCs_Human1.27731972
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27598780
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27579015
72VDR_21846776_ChIP-Seq_THP-1_Human1.25778262
73SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24905187
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.23918095
75IRF1_19129219_ChIP-ChIP_H3396_Human1.22940284
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21900729
77CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.21803231
78MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21748700
79SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.21175584
80SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20486455
81* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19974648
82FOXM1_23109430_ChIP-Seq_U2OS_Human1.19792883
83FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17026924
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16480482
85BCL6_27268052_Chip-Seq_Bcells_Human1.16181978
86NOTCH1_21737748_ChIP-Seq_TLL_Human1.16022092
87ZNF274_21170338_ChIP-Seq_K562_Hela1.15981456
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14863342
89HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13507369
90E2F1_21310950_ChIP-Seq_MCF-7_Human1.13206024
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13101882
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11832975
93SOX2_16153702_ChIP-ChIP_HESCs_Human1.11670528
94KDM5A_27292631_Chip-Seq_BREAST_Human1.11123167
95ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10938719
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10152849
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09193697
98P68_20966046_ChIP-Seq_HELA_Human1.09120874
99PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07508039
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05658218
101PHF8_20622854_ChIP-Seq_HELA_Human1.00776060
102YY1_22570637_ChIP-Seq_MALME-3M_Human1.00760305
103CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00013474
104THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00012739
105PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99141289
106* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99078436
107LXR_22292898_ChIP-Seq_THP-1_Human0.98992916
108E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98810315
109CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98765513
110BCOR_27268052_Chip-Seq_Bcells_Human0.98611973
111ELF1_20517297_ChIP-Seq_JURKAT_Human0.98522927
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98327418
113EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97977807
114NANOG_16153702_ChIP-ChIP_HESCs_Human0.97034622
115KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96587860
116TTF2_22483619_ChIP-Seq_HELA_Human0.96424142
117RXRA_24833708_ChIP-Seq_LIVER_Mouse0.96192683
118GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96072778
119* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95151714
120LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94059033
121POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93521956
122SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92987323
123OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92781692
124CTCF_26484167_Chip-Seq_Bcells_Mouse0.92752336
125SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.91852174
126CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91466943
127ZNF263_19887448_ChIP-Seq_K562_Human0.91404200
128GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89089017
129ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87166534
130SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87009415
131TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84832056
132CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83151500
133RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.81242498
134CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.80332129

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.54604389
2MP0005360_urolithiasis5.38212045
3MP0005365_abnormal_bile_salt4.32725235
4MP0005085_abnormal_gallbladder_physiolo4.21937427
5MP0003646_muscle_fatigue3.82469491
6MP0003806_abnormal_nucleotide_metabolis3.77334372
7MP0008875_abnormal_xenobiotic_pharmacok3.51797993
8MP0006292_abnormal_olfactory_placode2.91941739
9MP0006036_abnormal_mitochondrial_physio2.90235067
10MP0010030_abnormal_orbit_morphology2.84195110
11MP0001529_abnormal_vocalization2.79866153
12MP0009840_abnormal_foam_cell2.75426188
13MP0005332_abnormal_amino_acid2.66737921
14MP0003136_yellow_coat_color2.45776269
15MP0008932_abnormal_embryonic_tissue2.44395766
16MP0002837_dystrophic_cardiac_calcinosis2.44288085
17MP0010329_abnormal_lipoprotein_level2.36065239
18MP0004133_heterotaxia2.29546443
19MP0008789_abnormal_olfactory_epithelium2.19090700
20MP0006035_abnormal_mitochondrial_morpho2.18036879
21MP0003252_abnormal_bile_duct2.10953080
22MP0001764_abnormal_homeostasis2.01188233
23MP0005394_taste/olfaction_phenotype1.93744631
24MP0005499_abnormal_olfactory_system1.93744631
25MP0001666_abnormal_nutrient_absorption1.90405352
26MP0000049_abnormal_middle_ear1.90377204
27MP0002938_white_spotting1.74632716
28MP0005319_abnormal_enzyme/_coenzyme1.72758716
29MP0003195_calcinosis1.72590857
30MP0001188_hyperpigmentation1.71822002
31MP0001293_anophthalmia1.70685181
32MP0005083_abnormal_biliary_tract1.70362354
33MP0004145_abnormal_muscle_electrophysio1.69647740
34MP0005584_abnormal_enzyme/coenzyme_acti1.69442134
35MP0000609_abnormal_liver_physiology1.58323068
36MP0000372_irregular_coat_pigmentation1.57806680
37MP0003786_premature_aging1.56210237
38MP0003191_abnormal_cellular_cholesterol1.55642298
39MP0008007_abnormal_cellular_replicative1.53603845
40MP0004215_abnormal_myocardial_fiber1.53165580
41MP0004130_abnormal_muscle_cell1.53101849
42MP0005451_abnormal_body_composition1.52174720
43MP0005330_cardiomyopathy1.48648759
44MP0004147_increased_porphyrin_level1.45793851
45MP0005266_abnormal_metabolism1.45343575
46MP0009379_abnormal_foot_pigmentation1.44391773
47MP0004084_abnormal_cardiac_muscle1.43670326
48MP0002118_abnormal_lipid_homeostasis1.41593316
49MP0000751_myopathy1.41386678
50MP0005670_abnormal_white_adipose1.40725324
51MP0002102_abnormal_ear_morphology1.40041131
52MP0004036_abnormal_muscle_relaxation1.39237183
53MP0004019_abnormal_vitamin_homeostasis1.38707036
54MP0002269_muscular_atrophy1.35596775
55MP0009643_abnormal_urine_homeostasis1.35266933
56MP0003693_abnormal_embryo_hatching1.33370070
57MP0004957_abnormal_blastocyst_morpholog1.31806684
58MP0003121_genomic_imprinting1.29969929
59MP0003186_abnormal_redox_activity1.29439538
60MP0003122_maternal_imprinting1.28953960
61MP0003119_abnormal_digestive_system1.27428522
62MP0002254_reproductive_system_inflammat1.26951445
63MP0003567_abnormal_fetal_cardiomyocyte1.21660720
64MP0003221_abnormal_cardiomyocyte_apopto1.18910419
65MP0008058_abnormal_DNA_repair1.15183089
66MP0003880_abnormal_central_pattern1.14781626
67MP0010094_abnormal_chromosome_stability1.14231817
68MP0006276_abnormal_autonomic_nervous1.13026078
69MP0005636_abnormal_mineral_homeostasis1.11866049
70MP0004043_abnormal_pH_regulation1.11525272
71MP0003937_abnormal_limbs/digits/tail_de1.08531055
72MP0001346_abnormal_lacrimal_gland1.07401791
73MP0002138_abnormal_hepatobiliary_system1.07281485
74MP0000749_muscle_degeneration1.06390611
75MP0004142_abnormal_muscle_tone1.05810369
76MP0001853_heart_inflammation1.05594701
77MP0002736_abnormal_nociception_after1.05315776
78MP0000598_abnormal_liver_morphology1.04507183
79MP0005075_abnormal_melanosome_morpholog1.03266534
80MP0001905_abnormal_dopamine_level1.01362567
81MP0003283_abnormal_digestive_organ1.00367662
82MP0002638_abnormal_pupillary_reflex1.00073530
83MP0008961_abnormal_basal_metabolism0.99520245
84MP0008057_abnormal_DNA_replication0.99433303
85MP0002751_abnormal_autonomic_nervous0.98948949
86MP0002249_abnormal_larynx_morphology0.97010652
87MP0002234_abnormal_pharynx_morphology0.96665799
88MP0002210_abnormal_sex_determination0.96057706
89MP0003763_abnormal_thymus_physiology0.94525477
90MP0000689_abnormal_spleen_morphology0.94262815
91MP0003077_abnormal_cell_cycle0.94218766
92MP0002697_abnormal_eye_size0.94106880
93MP0002085_abnormal_embryonic_tissue0.92224224
94MP0003315_abnormal_perineum_morphology0.92012567
95MP0002653_abnormal_ependyma_morphology0.91377733
96MP0002396_abnormal_hematopoietic_system0.91038751
97MP0000778_abnormal_nervous_system0.90782927
98MP0000647_abnormal_sebaceous_gland0.90276178
99MP0003718_maternal_effect0.90095789
100MP0002822_catalepsy0.89866382
101MP0000358_abnormal_cell_content/0.89631508
102MP0003137_abnormal_impulse_conducting0.89306526
103MP0003123_paternal_imprinting0.88363729
104MP0002160_abnormal_reproductive_system0.88275763
105MP0003868_abnormal_feces_composition0.88161292
106MP0005376_homeostasis/metabolism_phenot0.86443177
107MP0001697_abnormal_embryo_size0.86100384
108MP0005377_hearing/vestibular/ear_phenot0.85642625
109MP0003878_abnormal_ear_physiology0.85642625
110MP0009642_abnormal_blood_homeostasis0.83608790
111MP0001544_abnormal_cardiovascular_syste0.83389735
112MP0005385_cardiovascular_system_phenoty0.83389735
113MP0003755_abnormal_palate_morphology0.82917258
114MP0000631_abnormal_neuroendocrine_gland0.82597206
115MP0003787_abnormal_imprinting0.82585963
116MP0005535_abnormal_body_temperature0.82409239
117MP0008872_abnormal_physiological_respon0.81332900
118MP0002078_abnormal_glucose_homeostasis0.81243149
119MP0000747_muscle_weakness0.80728934
120MP0001145_abnormal_male_reproductive0.80585807
121MP0003938_abnormal_ear_development0.79717539
122MP0002084_abnormal_developmental_patter0.79394626
123MP0003861_abnormal_nervous_system0.78732126
124MP0000350_abnormal_cell_proliferation0.78589942
125MP0002233_abnormal_nose_morphology0.78015418
126MP0003011_delayed_dark_adaptation0.77894761
127MP0001929_abnormal_gametogenesis0.77655025
128MP0000653_abnormal_sex_gland0.76986025
129MP0002722_abnormal_immune_system0.76599984
130MP0002080_prenatal_lethality0.76586404
131MP0003111_abnormal_nucleus_morphology0.75681734
132MP0001835_abnormal_antigen_presentation0.75198942
133MP0008469_abnormal_protein_level0.75095528
134MP0002106_abnormal_muscle_physiology0.75058274
135MP0001730_embryonic_growth_arrest0.74334420
136MP0001984_abnormal_olfaction0.74242170
137MP0004087_abnormal_muscle_fiber0.74241358
138MP0000566_synostosis0.74187380
139MP0005380_embryogenesis_phenotype0.74073262
140MP0001672_abnormal_embryogenesis/_devel0.74073262
141MP0003656_abnormal_erythrocyte_physiolo0.72954683
142MP0010630_abnormal_cardiac_muscle0.72939195
143MP0001286_abnormal_eye_development0.72933054
144MP0002398_abnormal_bone_marrow0.72509323
145MP0000685_abnormal_immune_system0.72386558
146MP0001800_abnormal_humoral_immune0.70993914
147MP0009697_abnormal_copulation0.70104405
148MP0000313_abnormal_cell_death0.70042163
149MP0002136_abnormal_kidney_physiology0.69725934
150MP0006072_abnormal_retinal_apoptosis0.69335666
151MP0000538_abnormal_urinary_bladder0.68593918
152MP0000015_abnormal_ear_pigmentation0.68489945
153MP0003698_abnormal_male_reproductive0.68158873
154MP0001968_abnormal_touch/_nociception0.67546221
155MP0005084_abnormal_gallbladder_morpholo0.67500097
156MP0002332_abnormal_exercise_endurance0.66887309
157MP0001756_abnormal_urination0.66067616
158MP0002127_abnormal_cardiovascular_syste0.65622857
159MP0000750_abnormal_muscle_regeneration0.64208798
160MP0008877_abnormal_DNA_methylation0.63407657
161MP0009672_abnormal_birth_weight0.63274778
162MP0001873_stomach_inflammation0.61716017
163MP0002972_abnormal_cardiac_muscle0.60974300
164MP0002429_abnormal_blood_cell0.60599102
165MP0002876_abnormal_thyroid_physiology0.59566201
166MP0003984_embryonic_growth_retardation0.58699885
167MP0008874_decreased_physiological_sensi0.58109412
168MP0001765_abnormal_ion_homeostasis0.57608994
169MP0005464_abnormal_platelet_physiology0.55881206
170MP0000703_abnormal_thymus_morphology0.55585961
171MP0002088_abnormal_embryonic_growth/wei0.55044392

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinemia (HP:0002154)4.64884031
2Hyperglycinuria (HP:0003108)4.35492845
3Hyperammonemia (HP:0001987)4.22290416
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.21161222
5Hepatic necrosis (HP:0002605)4.14409239
6Abnormality of glycine metabolism (HP:0010895)4.08659581
7Abnormality of serine family amino acid metabolism (HP:0010894)4.08659581
8Ketosis (HP:0001946)4.03262918
9Hepatocellular necrosis (HP:0001404)3.95495991
10Abnormality of fatty-acid metabolism (HP:0004359)3.87354235
11Increased hepatocellular lipid droplets (HP:0006565)3.55792922
12Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.54276540
13Hypobetalipoproteinemia (HP:0003563)3.53576664
14Gout (HP:0001997)3.53321539
15Myoglobinuria (HP:0002913)3.44556027
16Abnormality of monocarboxylic acid metabolism (HP:0010996)3.38606017
17Intrahepatic cholestasis (HP:0001406)3.36879935
18Abnormality of dicarboxylic acid metabolism (HP:0010995)3.36681530
19Dicarboxylic aciduria (HP:0003215)3.36681530
20Cerebral edema (HP:0002181)3.35354616
21Colon cancer (HP:0003003)3.30262769
22Hyperlipoproteinemia (HP:0010980)3.29201646
23Acute encephalopathy (HP:0006846)3.28260160
24Ragged-red muscle fibers (HP:0003200)3.25108299
25Lethargy (HP:0001254)3.24478198
26Abnormal mitochondria in muscle tissue (HP:0008316)3.23222277
27Ketoacidosis (HP:0001993)3.19639451
28Delayed CNS myelination (HP:0002188)3.19412539
29Rhabdomyolysis (HP:0003201)3.18802849
30Generalized aminoaciduria (HP:0002909)3.18289408
31Abnormality of serum amino acid levels (HP:0003112)3.17515083
32Lactic acidosis (HP:0003128)3.13477135
33Increased muscle lipid content (HP:0009058)3.09391821
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.07330810
35Decreased activity of mitochondrial respiratory chain (HP:0008972)3.07330810
36Metabolic acidosis (HP:0001942)3.06512492
37Xanthomatosis (HP:0000991)3.01982670
38Renal Fanconi syndrome (HP:0001994)3.00219475
39Increased CSF lactate (HP:0002490)2.94637283
40Increased serum lactate (HP:0002151)2.91557508
41Hypoglycemic coma (HP:0001325)2.90670556
42Abnormality of the labia minora (HP:0012880)2.90394325
43Abnormal number of erythroid precursors (HP:0012131)2.85817337
44Acute necrotizing encephalopathy (HP:0006965)2.84462320
45Increased intramyocellular lipid droplets (HP:0012240)2.81196344
46Mitochondrial inheritance (HP:0001427)2.75750807
47Deep venous thrombosis (HP:0002625)2.69675012
48CNS demyelination (HP:0007305)2.58772594
49Abnormality of cells of the erythroid lineage (HP:0012130)2.58447332
50Reticulocytopenia (HP:0001896)2.56003060
51Late onset (HP:0003584)2.55126728
52Abnormality of sulfur amino acid metabolism (HP:0004339)2.55086445
53Abnormality of aspartate family amino acid metabolism (HP:0010899)2.54634057
54Abnormality of glutamine family amino acid metabolism (HP:0010902)2.51147522
55Type I transferrin isoform profile (HP:0003642)2.48611369
56Hypolipoproteinemia (HP:0010981)2.45429987
57Abnormality of pyrimidine metabolism (HP:0004353)2.45321465
58Hyperbilirubinemia (HP:0002904)2.45177125
59Abnormality of glycolysis (HP:0004366)2.44951438
60Increased serum pyruvate (HP:0003542)2.44951438
61Abnormality of alanine metabolism (HP:0010916)2.43769430
62Hyperalaninemia (HP:0003348)2.43769430
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.43769430
64Hypoplasia of the pons (HP:0012110)2.40667632
65Vomiting (HP:0002013)2.38122811
66Palpitations (HP:0001962)2.37553035
67Prolonged partial thromboplastin time (HP:0003645)2.37329813
68Exercise-induced myalgia (HP:0003738)2.36996230
69Methylmalonic acidemia (HP:0002912)2.34560942
70Abnormality of nucleobase metabolism (HP:0010932)2.30633136
71Progressive muscle weakness (HP:0003323)2.29985433
72Abnormality of the pons (HP:0007361)2.29805142
73Abnormality of methionine metabolism (HP:0010901)2.26466521
74Proximal tubulopathy (HP:0000114)2.26178201
75Exertional dyspnea (HP:0002875)2.25674887
76Abnormality of purine metabolism (HP:0004352)2.23288972
77Emotional lability (HP:0000712)2.21174644
78Multiple enchondromatosis (HP:0005701)2.18130911
79Methylmalonic aciduria (HP:0012120)2.17256141
80Exercise-induced muscle cramps (HP:0003710)2.17226415
81Abnormal protein N-linked glycosylation (HP:0012347)2.15139536
82Abnormal protein glycosylation (HP:0012346)2.15139536
83Abnormal glycosylation (HP:0012345)2.15139536
84Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15139536
85Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.13968848
86Exercise intolerance (HP:0003546)2.12502876
87Hyperuricemia (HP:0002149)2.11982591
88Increased purine levels (HP:0004368)2.11982591
89Respiratory difficulties (HP:0002880)2.11821530
90Abnormality of the lower motor neuron (HP:0002366)2.10071267
91Optic disc pallor (HP:0000543)2.09181760
92Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.07055041
93Lipid accumulation in hepatocytes (HP:0006561)2.07000645
94Progressive macrocephaly (HP:0004481)2.06073957
95Neonatal onset (HP:0003623)2.05704303
96Pendular nystagmus (HP:0012043)2.04633519
97Sudden death (HP:0001699)2.04372747
98Horseshoe kidney (HP:0000085)2.03128987
99Rib fusion (HP:0000902)2.02459860
100Type 2 muscle fiber atrophy (HP:0003554)2.00033654
101Atrioventricular block (HP:0001678)1.98907545
102Abnormality of urine glucose concentration (HP:0011016)1.97436978
103Glycosuria (HP:0003076)1.97436978
104Limb hypertonia (HP:0002509)1.97094064
105Muscle fiber atrophy (HP:0100295)1.96964067
106Respiratory failure (HP:0002878)1.96485825
107Cortical dysplasia (HP:0002539)1.94857220
108Gliosis (HP:0002171)1.94089007
109Degeneration of anterior horn cells (HP:0002398)1.93986361
110Abnormality of the anterior horn cell (HP:0006802)1.93986361
111Sclerocornea (HP:0000647)1.93875849
112Irritability (HP:0000737)1.92424163
113Opisthotonus (HP:0002179)1.91923601
114Abnormality of the ileum (HP:0001549)1.91562499
115Meckel diverticulum (HP:0002245)1.91513836
116CNS hypomyelination (HP:0003429)1.91247035
117Hypoalphalipoproteinemia (HP:0003233)1.91169017
118Septo-optic dysplasia (HP:0100842)1.90920950
119Chromosomal breakage induced by crosslinking agents (HP:0003221)1.90276790
120Patellar aplasia (HP:0006443)1.90267481
121Delayed myelination (HP:0012448)1.88561144
122Progressive external ophthalmoplegia (HP:0000590)1.87229217
123Spastic diplegia (HP:0001264)1.87171428
124Cerebral hypomyelination (HP:0006808)1.86251343
125Cholecystitis (HP:0001082)1.86065562
126Abnormal gallbladder physiology (HP:0012438)1.86065562
127Reduced antithrombin III activity (HP:0001976)1.84653804
128Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84264237
129Fat malabsorption (HP:0002630)1.84132532
130Lissencephaly (HP:0001339)1.83178052
131Absent thumb (HP:0009777)1.82158029
132Microvesicular hepatic steatosis (HP:0001414)1.81346677
133Leukodystrophy (HP:0002415)1.80022442
134IgM deficiency (HP:0002850)1.79167691
135Retinal dysplasia (HP:0007973)1.79153118
136Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78667748
137Abnormality of the metopic suture (HP:0005556)1.78427898
138Aplasia/Hypoplasia of the patella (HP:0006498)1.78355374
139Nausea (HP:0002018)1.77996303
140Cholelithiasis (HP:0001081)1.76567636
141Optic nerve coloboma (HP:0000588)1.74083084
142Hypoplasia of the capital femoral epiphysis (HP:0003090)1.73823795
143Neoplasm of the adrenal cortex (HP:0100641)1.73165641
144Neoplasm of head and neck (HP:0012288)1.71400050
145Esophageal neoplasm (HP:0100751)1.71400050
146Hypercholesterolemia (HP:0003124)1.70783626
147Birth length less than 3rd percentile (HP:0003561)1.70148431
148Aplasia/Hypoplasia of the uvula (HP:0010293)1.67502867
149Neoplasm of the adrenal gland (HP:0100631)1.65867281
150Abnormality of renal resorption (HP:0011038)1.64737188
151Prominent metopic ridge (HP:0005487)1.64237286
152Hyperphosphaturia (HP:0003109)1.62871485
153Medial flaring of the eyebrow (HP:0010747)1.62757421
154Absent septum pellucidum (HP:0001331)1.62415109
155Chromsome breakage (HP:0040012)1.61807002
156Aplasia/Hypoplasia of the sacrum (HP:0008517)1.60410145
157Pancreatic fibrosis (HP:0100732)1.59016166

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.91679378
2BCKDK5.19657116
3PDK33.69033001
4PDK43.69033001
5MAP4K13.64924768
6NEK12.72954230
7SRPK12.70557804
8BUB12.68227660
9TAF12.60124728
10ERN12.38852120
11TRIM282.32195625
12FLT32.30401687
13GRK62.29751789
14PINK12.21085573
15ZAK2.19098618
16NUAK12.16201976
17PKN21.99193095
18MAP4K21.92074078
19DYRK21.80597252
20WEE11.80161065
21MAPKAPK31.77848469
22DAPK11.77425449
23MAP2K31.74651312
24TESK21.74650983
25WNK31.74091632
26TSSK61.73193928
27LMTK21.71413931
28PDK21.70485150
29PBK1.68400002
30STK161.67764234
31FGFR41.66037969
32MYLK1.65569500
33MAP3K91.63703120
34BCR1.59227553
35PLK41.57679639
36PLK31.56574714
37SIK31.48905394
38EIF2AK11.48588468
39ACVR1B1.43794098
40CSNK1G31.40752866
41CDK191.37068252
42MAP3K41.32256873
43PRPF4B1.28151883
44BTK1.27373748
45MAP3K111.22820635
46SMG11.21143401
47PIM21.20998284
48TNIK1.19415482
49EIF2AK31.17550504
50MAP2K41.17353021
51CSNK1A1L1.16695789
52TYK21.14909865
53OBSCN1.14562592
54TAOK21.14190954
55MKNK11.11429828
56CSNK1G11.09866470
57KDR1.08720673
58MAP3K101.08554084
59CSF1R1.07179295
60PHKG21.07078841
61PHKG11.07078841
62CSNK1G21.06002895
63LIMK11.03805208
64ZAP700.99754799
65CDC70.99019190
66MKNK20.96648622
67SYK0.95679795
68KIT0.95066864
69NEK20.94857113
70CHEK20.93429418
71MAP2K60.92400292
72NME10.91932115
73MAPK120.90867385
74ABL20.89908189
75BMPR1B0.88506996
76TTN0.86051599
77MAP3K120.84617918
78CDK120.83482763
79CDK40.82790031
80BRSK10.78153027
81DYRK30.77715403
82AURKB0.72031906
83UHMK10.71873345
84MAPK110.71681327
85WNK40.70652379
86CDK70.70266334
87CCNB10.69783119
88TESK10.69560433
89RPS6KA40.68758404
90MAPK70.67780279
91VRK10.67142056
92NME20.66509883
93LRRK20.63551887
94IRAK30.62833045
95PAK40.62825740
96EPHB20.62025464
97TLK10.61351131
98MAP3K60.61099156
99MAP3K70.60501809
100CSNK2A10.59139762
101MUSK0.58751058
102CDK90.56960548
103MAPK40.56823458
104EEF2K0.53739070
105EPHA40.53224752
106PASK0.50752089
107EIF2AK20.50585426
108ARAF0.49352170
109TRIB30.48525520
110TGFBR10.47680656
111PRKCI0.47247565
112PRKCG0.46681189
113MARK10.45761785
114CHEK10.45301762
115MAP2K70.45101583
116DAPK30.44017526
117MAPKAPK50.43607723
118MAP3K130.42935183
119PLK10.41969361
120TIE10.41687391
121CDK140.41594031
122CAMK40.40825803
123RPS6KA50.39622007
124ATM0.38495987
125INSRR0.38185143
126CDK80.37210142
127EPHA20.36783997
128TBK10.36494714
129ILK0.36407235
130AKT20.35390930
131CDK180.34832637
132PDK10.34511352
133AURKA0.34069434
134CSNK1A10.33393805
135CDK11A0.33015962
136CDK150.31040422
137TTK0.28954297
138MAPK130.28602144
139PAK10.27384586
140ATR0.27054139
141RPS6KB20.27045349
142LYN0.25965636
143BRAF0.25105375
144ICK0.23303335
145STK380.22758806
146RPS6KL10.22403918
147RPS6KC10.22403918
148CSNK2A20.21481046
149GRK10.21196098
150RPS6KA60.20589370
151TXK0.19711097
152PRKAA10.19707716

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.82428432
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.43821977
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.36328654
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.17561711
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.72460515
6Propanoate metabolism_Homo sapiens_hsa006402.67799349
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.59717350
8Fatty acid degradation_Homo sapiens_hsa000712.56872398
9Carbon metabolism_Homo sapiens_hsa012002.43506248
10Pyruvate metabolism_Homo sapiens_hsa006202.28173027
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.24590251
12Biosynthesis of amino acids_Homo sapiens_hsa012302.22230643
13Arginine biosynthesis_Homo sapiens_hsa002202.22177118
14Cyanoamino acid metabolism_Homo sapiens_hsa004602.08066098
15Cysteine and methionine metabolism_Homo sapiens_hsa002702.06124369
16Butanoate metabolism_Homo sapiens_hsa006502.03191533
17Tryptophan metabolism_Homo sapiens_hsa003802.00844072
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.00455565
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.86988249
20Peroxisome_Homo sapiens_hsa041461.83967243
21Fanconi anemia pathway_Homo sapiens_hsa034601.82642032
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74680786
23Protein export_Homo sapiens_hsa030601.71054729
24Nitrogen metabolism_Homo sapiens_hsa009101.66341151
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.66049741
26Fatty acid metabolism_Homo sapiens_hsa012121.65220772
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.61813855
28Pentose phosphate pathway_Homo sapiens_hsa000301.56152184
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.53382984
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.47070089
31Sulfur relay system_Homo sapiens_hsa041221.46500031
32beta-Alanine metabolism_Homo sapiens_hsa004101.42017507
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39857463
34Parkinsons disease_Homo sapiens_hsa050121.39071946
35Fructose and mannose metabolism_Homo sapiens_hsa000511.38966820
36Selenocompound metabolism_Homo sapiens_hsa004501.38165429
37Basal transcription factors_Homo sapiens_hsa030221.37959303
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.37282686
39Oxidative phosphorylation_Homo sapiens_hsa001901.34288950
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31628473
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29864776
42Folate biosynthesis_Homo sapiens_hsa007901.29173438
43RNA polymerase_Homo sapiens_hsa030201.27827422
44Steroid biosynthesis_Homo sapiens_hsa001001.25885479
45Proteasome_Homo sapiens_hsa030501.24824042
46DNA replication_Homo sapiens_hsa030301.20546194
47Phenylalanine metabolism_Homo sapiens_hsa003601.17477204
48Pyrimidine metabolism_Homo sapiens_hsa002401.16054756
49PPAR signaling pathway_Homo sapiens_hsa033201.15725130
50Ribosome_Homo sapiens_hsa030101.12401336
51One carbon pool by folate_Homo sapiens_hsa006701.04579549
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04184291
53Mismatch repair_Homo sapiens_hsa034301.03565031
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01427032
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01033447
56Chemical carcinogenesis_Homo sapiens_hsa052040.97162437
57Cell cycle_Homo sapiens_hsa041100.97019491
58Starch and sucrose metabolism_Homo sapiens_hsa005000.94723308
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94349913
60Base excision repair_Homo sapiens_hsa034100.92893761
61Caffeine metabolism_Homo sapiens_hsa002320.91732634
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90128425
63Arginine and proline metabolism_Homo sapiens_hsa003300.89299821
64Complement and coagulation cascades_Homo sapiens_hsa046100.88932514
65Fatty acid elongation_Homo sapiens_hsa000620.88632785
66Bile secretion_Homo sapiens_hsa049760.85867466
67Cardiac muscle contraction_Homo sapiens_hsa042600.84598566
68Tyrosine metabolism_Homo sapiens_hsa003500.83694492
69Homologous recombination_Homo sapiens_hsa034400.79563948
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79272018
71Huntingtons disease_Homo sapiens_hsa050160.77810037
72Lysine degradation_Homo sapiens_hsa003100.75352712
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.74874497
74Metabolic pathways_Homo sapiens_hsa011000.73610597
75Galactose metabolism_Homo sapiens_hsa000520.73492771
76Glutathione metabolism_Homo sapiens_hsa004800.71849705
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71108922
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70481955
79Histidine metabolism_Homo sapiens_hsa003400.68147671
80Retinol metabolism_Homo sapiens_hsa008300.67435337
81Vitamin B6 metabolism_Homo sapiens_hsa007500.62702703
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60094135
83Phototransduction_Homo sapiens_hsa047440.59873764
84Purine metabolism_Homo sapiens_hsa002300.59627117
85Nucleotide excision repair_Homo sapiens_hsa034200.58711818
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57938261
87Basal cell carcinoma_Homo sapiens_hsa052170.57893441
88Primary immunodeficiency_Homo sapiens_hsa053400.57294611
89RNA transport_Homo sapiens_hsa030130.57107972
90Alzheimers disease_Homo sapiens_hsa050100.56601263
91Spliceosome_Homo sapiens_hsa030400.55374363
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.53350870
93Fat digestion and absorption_Homo sapiens_hsa049750.53120342
94N-Glycan biosynthesis_Homo sapiens_hsa005100.51237442
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51148499
96p53 signaling pathway_Homo sapiens_hsa041150.48631772
97ABC transporters_Homo sapiens_hsa020100.48075305
98Glycerolipid metabolism_Homo sapiens_hsa005610.47550468
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45786499
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.42636309
101Vitamin digestion and absorption_Homo sapiens_hsa049770.42041313
102Glucagon signaling pathway_Homo sapiens_hsa049220.37821565
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37473438
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34312476
105Sulfur metabolism_Homo sapiens_hsa009200.34251513
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30370292
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27926861
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27366783
109Oocyte meiosis_Homo sapiens_hsa041140.25046252
110Collecting duct acid secretion_Homo sapiens_hsa049660.24962442
111Hippo signaling pathway_Homo sapiens_hsa043900.24670440
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24168292
113Hedgehog signaling pathway_Homo sapiens_hsa043400.24107037
114RNA degradation_Homo sapiens_hsa030180.23948493
115Regulation of autophagy_Homo sapiens_hsa041400.23846939
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20875784
117Vibrio cholerae infection_Homo sapiens_hsa051100.18273674
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16674806
119Insulin resistance_Homo sapiens_hsa049310.11708822
120Non-homologous end-joining_Homo sapiens_hsa034500.11602690
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.10560017
122Staphylococcus aureus infection_Homo sapiens_hsa051500.10400156
123Insulin signaling pathway_Homo sapiens_hsa049100.09866902
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.08371557
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.07953349
126mRNA surveillance pathway_Homo sapiens_hsa030150.07176905

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