ATP5O

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a component of the F-type ATPase found in the mitochondrial matrix. F-type ATPases are composed of a catalytic core and a membrane proton channel. The encoded protein appears to be part of the connector linking these two components and may be involved in transmission of conformational changes or proton conductance. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.82509642
2* respiratory electron transport chain (GO:0022904)8.53188995
3* electron transport chain (GO:0022900)8.31410027
4oxidative phosphorylation (GO:0006119)6.97613119
5tricarboxylic acid cycle (GO:0006099)6.59510068
6* ATP biosynthetic process (GO:0006754)5.75346870
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.52905216
8cotranslational protein targeting to membrane (GO:0006613)5.47726415
9protein targeting to ER (GO:0045047)5.41004110
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.20907046
11mitochondrial respiratory chain complex I assembly (GO:0032981)5.13491997
12NADH dehydrogenase complex assembly (GO:0010257)5.13491997
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.13491997
14protein localization to endoplasmic reticulum (GO:0070972)5.11946830
15* purine ribonucleoside triphosphate biosynthetic process (GO:0009206)5.11295419
16translational elongation (GO:0006414)5.09270055
17* purine nucleoside triphosphate biosynthetic process (GO:0009145)5.06423778
18protein complex biogenesis (GO:0070271)5.04164339
19NADH metabolic process (GO:0006734)4.99802842
20* hydrogen ion transmembrane transport (GO:1902600)4.86567862
21sarcomere organization (GO:0045214)4.79944509
22muscle filament sliding (GO:0030049)4.75150116
23actin-myosin filament sliding (GO:0033275)4.75150116
24inner mitochondrial membrane organization (GO:0007007)4.73492303
25maturation of SSU-rRNA (GO:0030490)4.70674175
26mitochondrial respiratory chain complex assembly (GO:0033108)4.69235323
27cellular protein complex disassembly (GO:0043624)4.67373294
28viral life cycle (GO:0019058)4.62718797
29translational initiation (GO:0006413)4.60824799
30chaperone-mediated protein transport (GO:0072321)4.60480834
31nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.58487718
32establishment of protein localization to mitochondrial membrane (GO:0090151)4.57150643
33ribosomal large subunit biogenesis (GO:0042273)4.56592728
34cardiac myofibril assembly (GO:0055003)4.55260444
35* ribonucleoside triphosphate biosynthetic process (GO:0009201)4.54550090
36aerobic respiration (GO:0009060)4.41597686
37heart contraction (GO:0060047)4.41396262
38heart process (GO:0003015)4.41396262
39regulation of acyl-CoA biosynthetic process (GO:0050812)4.27131204
40translation (GO:0006412)4.20109454
41succinate metabolic process (GO:0006105)4.19891257
42regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.18844563
43* proton transport (GO:0015992)4.15158140
44* hydrogen transport (GO:0006818)4.08197744
45regulation of coenzyme metabolic process (GO:0051196)4.06274227
46regulation of cofactor metabolic process (GO:0051193)4.06274227
47cardiac muscle contraction (GO:0060048)4.02750209
48* nucleoside triphosphate biosynthetic process (GO:0009142)4.02260701
49protein complex disassembly (GO:0043241)4.01359218
50myofibril assembly (GO:0030239)4.00779728
51regulation of mitochondrial translation (GO:0070129)3.99491618
52* purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.90001640
53* purine nucleoside monophosphate biosynthetic process (GO:0009127)3.90001640
54macromolecular complex disassembly (GO:0032984)3.87660307
55actin-mediated cell contraction (GO:0070252)3.87511821
56positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.85007310
57negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.84658463
58regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.76128831
59positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.75881889
60protein neddylation (GO:0045116)3.75133836
61cellular respiration (GO:0045333)3.73894988
62quinone biosynthetic process (GO:1901663)3.71196027
63ubiquinone biosynthetic process (GO:0006744)3.71196027
64negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.69035307
65negative regulation of ligase activity (GO:0051352)3.69035307
66protein targeting to membrane (GO:0006612)3.64377206
67regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.64109921
68anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.60187407
69termination of RNA polymerase III transcription (GO:0006386)3.60143338
70transcription elongation from RNA polymerase III promoter (GO:0006385)3.60143338
71cardiac muscle tissue morphogenesis (GO:0055008)3.59332986
72cullin deneddylation (GO:0010388)3.58627995
73oxaloacetate metabolic process (GO:0006107)3.57704301
74regulation of cellular respiration (GO:0043457)3.56307658
75regulation of relaxation of muscle (GO:1901077)3.54509922
76* mitochondrial transport (GO:0006839)3.53728598
77chromatin remodeling at centromere (GO:0031055)3.52635277
78regulation of oxidative phosphorylation (GO:0002082)3.52169051
79regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.50058592
80cardiac muscle cell development (GO:0055013)3.47923814
81nuclear-transcribed mRNA catabolic process (GO:0000956)3.46691591
82DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.44943938
83CENP-A containing nucleosome assembly (GO:0034080)3.43386553
84* generation of precursor metabolites and energy (GO:0006091)3.42563602
85cellular component biogenesis (GO:0044085)3.41887949
86establishment of integrated proviral latency (GO:0075713)3.40677516
87ubiquinone metabolic process (GO:0006743)3.40104648
88signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.39359664
89signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.39359664
90signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.39359664
91nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.38820236
92intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.37199129
93signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.37199129
94negative regulation of potassium ion transmembrane transport (GO:1901380)3.34183325
95exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.33595604
96ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.29645967
97positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.27435206
98signal transduction involved in DNA integrity checkpoint (GO:0072401)3.26908110
99signal transduction involved in DNA damage checkpoint (GO:0072422)3.26908110
100mRNA catabolic process (GO:0006402)3.26508612
101protein deneddylation (GO:0000338)3.25158110
102signal transduction involved in cell cycle checkpoint (GO:0072395)3.24610415
103regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.24312394
104muscle tissue morphogenesis (GO:0060415)3.24085799
105energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.22750950
106ATP hydrolysis coupled proton transport (GO:0015991)3.22750950
107regulation of actin filament-based movement (GO:1903115)3.21503713
108protein targeting to mitochondrion (GO:0006626)3.20709389
109cardiac cell development (GO:0055006)3.19683951
110establishment of protein localization to mitochondrion (GO:0072655)3.19533487
111striated muscle contraction (GO:0006941)3.18325380
112DNA damage response, detection of DNA damage (GO:0042769)3.17820822
113* ribonucleoside monophosphate biosynthetic process (GO:0009156)3.17003537
114regulation of cell communication by electrical coupling (GO:0010649)3.16956198
115protein-cofactor linkage (GO:0018065)3.15732112
116ribonucleoprotein complex biogenesis (GO:0022613)3.14168832
117* purine nucleoside biosynthetic process (GO:0042451)3.12923220
118* purine ribonucleoside biosynthetic process (GO:0046129)3.12923220
119cardiac muscle hypertrophy (GO:0003300)3.12536179
120ribosomal small subunit assembly (GO:0000028)3.11532367
121respiratory chain complex IV assembly (GO:0008535)3.11267021
122positive regulation of ligase activity (GO:0051351)3.10116200
123protein localization to mitochondrion (GO:0070585)3.09403278
124spliceosomal snRNP assembly (GO:0000387)3.08128399
125tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.04637776
126RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.04637776
127formation of translation preinitiation complex (GO:0001731)3.04530398
128regulation of cellular amino acid metabolic process (GO:0006521)3.03928680
129ventricular cardiac muscle cell action potential (GO:0086005)3.03889056
130rRNA modification (GO:0000154)3.02917960
131regulation of sarcomere organization (GO:0060297)3.01728671
132intracellular protein transmembrane import (GO:0044743)3.01593445
133cytochrome complex assembly (GO:0017004)3.01386401
134regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.01368004
135viral transcription (GO:0019083)3.01254584
136RNA catabolic process (GO:0006401)2.99778990
137regulation of sulfur metabolic process (GO:0042762)2.99449336
138striated muscle hypertrophy (GO:0014897)2.97404281
139* nucleoside monophosphate biosynthetic process (GO:0009124)2.95524189
140GTP biosynthetic process (GO:0006183)2.93520485
141regulation of ubiquitin-protein transferase activity (GO:0051438)2.93062080
142translational termination (GO:0006415)2.92512917
143ribosomal small subunit biogenesis (GO:0042274)2.90932752
144proteasome assembly (GO:0043248)2.90443001
145adult heart development (GO:0007512)2.89848607
146regulation of skeletal muscle contraction (GO:0014819)2.88569744
147purine nucleobase biosynthetic process (GO:0009113)2.87920424
148rRNA processing (GO:0006364)2.85331791
149regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.84757913
150actomyosin structure organization (GO:0031032)2.83694677
151telomere maintenance via semi-conservative replication (GO:0032201)2.83169384
152negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.82365587
153negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.81683942
154* mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.7543452
155* ATP synthesis coupled proton transport (GO:0015986)10.0581714
156* energy coupled proton transport, down electrochemical gradient (GO:0015985)10.0581714

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.89721998
2* ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.37296555
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.05622176
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.88149121
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.79821149
6* EST1_17652178_ChIP-ChIP_JURKAT_Human3.68740198
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.66803217
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.48689789
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.38833827
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.36330226
11* ETS1_20019798_ChIP-Seq_JURKAT_Human3.33071777
12MYC_18555785_ChIP-Seq_MESCs_Mouse3.26479996
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.00933475
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.96657778
15E2F7_22180533_ChIP-Seq_HELA_Human2.94907075
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.91223738
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.88990446
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.61247781
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.55587666
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.54130257
21* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.52930567
22* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.49906039
23YY1_21170310_ChIP-Seq_MESCs_Mouse2.38829394
24DCP1A_22483619_ChIP-Seq_HELA_Human2.20882799
25ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.12267961
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07945713
27* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.07586531
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.98555977
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94059790
30EZH2_22144423_ChIP-Seq_EOC_Human1.84794877
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81921031
32* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.81708621
33XRN2_22483619_ChIP-Seq_HELA_Human1.77661320
34VDR_23849224_ChIP-Seq_CD4+_Human1.74355213
35VDR_22108803_ChIP-Seq_LS180_Human1.73071397
36HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.70512477
37BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.70447187
38TTF2_22483619_ChIP-Seq_HELA_Human1.65961907
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61086688
40FOXP3_21729870_ChIP-Seq_TREG_Human1.50129615
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46940027
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46898069
43* GABP_19822575_ChIP-Seq_HepG2_Human1.46861727
44CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.45759410
45ELK1_19687146_ChIP-ChIP_HELA_Human1.44360617
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42681506
47* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.40792385
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39445756
49EP300_21415370_ChIP-Seq_HL-1_Mouse1.36237322
50ELK1_22589737_ChIP-Seq_MCF10A_Human1.30548124
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28830881
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27863568
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23729186
54MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.22356033
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21109043
56CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20434300
57GATA4_21415370_ChIP-Seq_HL-1_Mouse1.20276962
58FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19222605
59CTCF_18555785_ChIP-Seq_MESCs_Mouse1.18792352
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17512037
61SOX2_16153702_ChIP-ChIP_HESCs_Human1.16336731
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.15327310
63EWS_26573619_Chip-Seq_HEK293_Human1.15306853
64IGF1R_20145208_ChIP-Seq_DFB_Human1.13940031
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10531581
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10036652
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09854841
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09438439
69NANOG_16153702_ChIP-ChIP_HESCs_Human1.08434663
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08170055
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07746093
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07656051
73AR_21909140_ChIP-Seq_LNCAP_Human1.07605256
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07146681
75FOXM1_23109430_ChIP-Seq_U2OS_Human1.06466166
76MYC_18940864_ChIP-ChIP_HL60_Human1.04592591
77CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03232276
78KDM5A_27292631_Chip-Seq_BREAST_Human1.02270553
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00134241
80SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95938870
81* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92695821
82OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92394622
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91324860
84* SOX17_20123909_ChIP-Seq_XEN_Mouse0.90223987
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88268818
86IRF1_19129219_ChIP-ChIP_H3396_Human0.88100293
87TAF15_26573619_Chip-Seq_HEK293_Human0.86557577
88YY1_22570637_ChIP-Seq_MALME-3M_Human0.85934856
89PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85180135
90* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85172813
91TP53_22573176_ChIP-Seq_HFKS_Human0.84363006
92SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83388874
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83359838
94ELF1_17652178_ChIP-ChIP_JURKAT_Human0.82573088
95* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.82553761
96* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81903101
97FUS_26573619_Chip-Seq_HEK293_Human0.81491420
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.79398994
99MYCN_18555785_ChIP-Seq_MESCs_Mouse0.79183733
100ERG_20887958_ChIP-Seq_HPC-7_Mouse0.77819713
101ZNF274_21170338_ChIP-Seq_K562_Hela0.76670405
102CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.76230747
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75877151
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.74600735
105* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74435149
106SOX2_18555785_ChIP-Seq_MESCs_Mouse0.73930578
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.73816941
108ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.73572020
109EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.73392945
110HTT_18923047_ChIP-ChIP_STHdh_Human0.72698632
111ZNF263_19887448_ChIP-Seq_K562_Human0.71738859
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.71709398
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.71687975
114KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.71542072
115BMI1_23680149_ChIP-Seq_NPCS_Mouse0.71420308
116TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70697007
117SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.69684427
118FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.69247447
119MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.68848851
120EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.67594914
121PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.66941359
122SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.65838296
123E2F4_17652178_ChIP-ChIP_JURKAT_Human0.64709021
124CTBP1_25329375_ChIP-Seq_LNCAP_Human0.64150577
125PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.64023153
126REST_19997604_ChIP-ChIP_NEURONS_Mouse0.63663421
127POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.62719295

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.83808714
2MP0003646_muscle_fatigue4.60163420
3MP0004084_abnormal_cardiac_muscle4.56883292
4MP0000751_myopathy4.08113633
5MP0004215_abnormal_myocardial_fiber3.97764324
6MP0004036_abnormal_muscle_relaxation3.66025619
7MP0000749_muscle_degeneration3.63865860
8MP0006036_abnormal_mitochondrial_physio3.35320619
9MP0005330_cardiomyopathy3.21389826
10MP0006292_abnormal_olfactory_placode2.85955338
11MP0008058_abnormal_DNA_repair2.77704341
12MP0002972_abnormal_cardiac_muscle2.68635757
13MP0003137_abnormal_impulse_conducting2.55247435
14MP0006035_abnormal_mitochondrial_morpho2.53770812
15MP0003136_yellow_coat_color2.43352778
16MP0001529_abnormal_vocalization2.40527364
17MP0002938_white_spotting2.35348857
18MP0003806_abnormal_nucleotide_metabolis2.33865073
19MP0005620_abnormal_muscle_contractility2.32209675
20MP0003693_abnormal_embryo_hatching2.31039167
21MP0008775_abnormal_heart_ventricle2.25824425
22MP0004484_altered_response_of2.24651141
23MP0004087_abnormal_muscle_fiber2.18997447
24MP0008995_early_reproductive_senescence2.18311093
25MP0010094_abnormal_chromosome_stability2.14939944
26MP0004145_abnormal_muscle_electrophysio2.09265752
27MP0005385_cardiovascular_system_phenoty2.06218892
28MP0001544_abnormal_cardiovascular_syste2.06218892
29MP0002106_abnormal_muscle_physiology2.03020071
30MP0000750_abnormal_muscle_regeneration2.02392582
31MP0008789_abnormal_olfactory_epithelium1.99822653
32MP0009379_abnormal_foot_pigmentation1.95978392
33MP0003880_abnormal_central_pattern1.90617682
34MP0002102_abnormal_ear_morphology1.90331319
35MP0006138_congestive_heart_failure1.89731637
36MP0003221_abnormal_cardiomyocyte_apopto1.88398505
37MP0004085_abnormal_heartbeat1.84556722
38MP0002269_muscular_atrophy1.79156134
39MP0003111_abnormal_nucleus_morphology1.69128337
40MP0002332_abnormal_exercise_endurance1.67700083
41MP0005369_muscle_phenotype1.65410041
42MP0000747_muscle_weakness1.63060087
43MP0003786_premature_aging1.61610477
44MP0003077_abnormal_cell_cycle1.58923498
45MP0010630_abnormal_cardiac_muscle1.56115561
46MP0003122_maternal_imprinting1.53282522
47MP0001293_anophthalmia1.53272749
48MP0006276_abnormal_autonomic_nervous1.51941887
49MP0005394_taste/olfaction_phenotype1.51774386
50MP0005499_abnormal_olfactory_system1.51774386
51MP0002127_abnormal_cardiovascular_syste1.51132385
52MP0000759_abnormal_skeletal_muscle1.47689770
53MP0010030_abnormal_orbit_morphology1.45183997
54MP0008877_abnormal_DNA_methylation1.44085562
55MP0003011_delayed_dark_adaptation1.38060714
56MP0002736_abnormal_nociception_after1.37281702
57MP0004233_abnormal_muscle_weight1.36755452
58MP0005408_hypopigmentation1.33704953
59MP0005266_abnormal_metabolism1.33189257
60MP0001905_abnormal_dopamine_level1.33136572
61MP0004130_abnormal_muscle_cell1.32313770
62MP0002822_catalepsy1.29358843
63MP0003567_abnormal_fetal_cardiomyocyte1.28119633
64MP0003123_paternal_imprinting1.27138549
65MP0004043_abnormal_pH_regulation1.25903033
66MP0003186_abnormal_redox_activity1.19178094
67MP0002638_abnormal_pupillary_reflex1.14971807
68MP0001188_hyperpigmentation1.09767010
69MP0000631_abnormal_neuroendocrine_gland1.08148795
70MP0005084_abnormal_gallbladder_morpholo1.08075868
71MP0002234_abnormal_pharynx_morphology1.07878440
72MP0005253_abnormal_eye_physiology1.07633045
73MP0004142_abnormal_muscle_tone1.05380991
74MP0005075_abnormal_melanosome_morpholog1.05351428
75MP0004924_abnormal_behavior1.05294239
76MP0005386_behavior/neurological_phenoty1.05294239
77MP0002095_abnormal_skin_pigmentation1.04832634
78MP0003950_abnormal_plasma_membrane1.04326248
79MP0005451_abnormal_body_composition1.03192620
80MP0003828_pulmonary_edema1.03099684
81MP0000566_synostosis1.02947409
82MP0001968_abnormal_touch/_nociception1.02467063
83MP0003941_abnormal_skin_development1.02016640
84MP0009046_muscle_twitch1.00213598
85MP0002210_abnormal_sex_determination0.99969297
86MP0003787_abnormal_imprinting0.99628139
87MP0005551_abnormal_eye_electrophysiolog0.98671456
88MP0001727_abnormal_embryo_implantation0.95997936
89MP0002090_abnormal_vision0.95647083
90MP0005423_abnormal_somatic_nervous0.95570572
91MP0002735_abnormal_chemical_nociception0.95380887
92MP0004147_increased_porphyrin_level0.95139951
93MP0001440_abnormal_grooming_behavior0.94748103
94MP0000230_abnormal_systemic_arterial0.92468692
95MP0003938_abnormal_ear_development0.91103342
96MP0002653_abnormal_ependyma_morphology0.91025256
97MP0008007_abnormal_cellular_replicative0.90623627
98MP0000049_abnormal_middle_ear0.88793610
99MP0005332_abnormal_amino_acid0.88591487
100MP0005645_abnormal_hypothalamus_physiol0.85972140
101MP0002272_abnormal_nervous_system0.85087446
102MP0004133_heterotaxia0.84520098
103MP0001286_abnormal_eye_development0.83825837
104MP0002233_abnormal_nose_morphology0.82738004
105MP0005646_abnormal_pituitary_gland0.82732979
106MP0005171_absent_coat_pigmentation0.82301949
107MP0009745_abnormal_behavioral_response0.81801936
108MP0004742_abnormal_vestibular_system0.80414439
109MP0002160_abnormal_reproductive_system0.80361361
110MP0005165_increased_susceptibility_to0.80277366
111MP0001984_abnormal_olfaction0.78685178
112MP0002277_abnormal_respiratory_mucosa0.77202308
113MP0000372_irregular_coat_pigmentation0.76500145
114MP0003937_abnormal_limbs/digits/tail_de0.76369856
115MP0001145_abnormal_male_reproductive0.75505194
116MP0002751_abnormal_autonomic_nervous0.75419098
117MP0002752_abnormal_somatic_nervous0.75260059
118MP0002064_seizures0.75046694
119MP0001929_abnormal_gametogenesis0.74960244
120MP0000653_abnormal_sex_gland0.74912011
121MP0003890_abnormal_embryonic-extraembry0.73631176
122MP0005535_abnormal_body_temperature0.73384345
123MP0001485_abnormal_pinna_reflex0.72771821
124MP0009697_abnormal_copulation0.72762185
125MP0001324_abnormal_eye_pigmentation0.72124166
126MP0005377_hearing/vestibular/ear_phenot0.71145987
127MP0003878_abnormal_ear_physiology0.71145987
128MP0005376_homeostasis/metabolism_phenot0.69589454
129MP0002697_abnormal_eye_size0.69121313
130MP0002734_abnormal_mechanical_nocicepti0.68845839
131MP0004957_abnormal_blastocyst_morpholog0.66336360
132MP0002067_abnormal_sensory_capabilities0.64909496
133MP0008004_abnormal_stomach_pH0.62568914
134MP0005636_abnormal_mineral_homeostasis0.62104157
135MP0000358_abnormal_cell_content/0.62086195
136MP0003635_abnormal_synaptic_transmissio0.61912850
137MP0001764_abnormal_homeostasis0.61291945
138MP0004510_myositis0.61061943
139MP0005584_abnormal_enzyme/coenzyme_acti0.59606258
140MP0001970_abnormal_pain_threshold0.58998829
141MP0008872_abnormal_physiological_respon0.58962852
142MP0000343_altered_response_to0.58268377
143MP0003718_maternal_effect0.57740711
144MP0003121_genomic_imprinting0.57406285
145MP0003195_calcinosis0.56136472
146MP0002876_abnormal_thyroid_physiology0.55524374
147MP0000013_abnormal_adipose_tissue0.55148993
148MP0002163_abnormal_gland_morphology0.55139334
149MP0002572_abnormal_emotion/affect_behav0.53817067
150MP0000266_abnormal_heart_morphology0.53012366
151MP0001664_abnormal_digestion0.52071327
152MP0008932_abnormal_embryonic_tissue0.51363176
153MP0003315_abnormal_perineum_morphology0.47430864
154MP0006072_abnormal_retinal_apoptosis0.46595139
155MP0002063_abnormal_learning/memory/cond0.45945518

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.49948734
2Abnormal mitochondria in muscle tissue (HP:0008316)7.09675519
3Acute encephalopathy (HP:0006846)6.38989360
4Mitochondrial inheritance (HP:0001427)6.34336617
5Progressive macrocephaly (HP:0004481)6.34072189
6Hepatocellular necrosis (HP:0001404)5.69771114
7Increased CSF lactate (HP:0002490)5.69455273
8Hepatic necrosis (HP:0002605)5.51849260
9Cerebral edema (HP:0002181)4.86412024
10Abnormality of glycolysis (HP:0004366)4.83347058
11Increased serum pyruvate (HP:0003542)4.83347058
12Reticulocytopenia (HP:0001896)4.68765547
13Sudden death (HP:0001699)4.65729155
14Exercise intolerance (HP:0003546)4.31698088
15Increased hepatocellular lipid droplets (HP:0006565)4.26557362
16Lipid accumulation in hepatocytes (HP:0006561)4.16909565
17Respiratory failure (HP:0002878)4.15751339
18Lactic acidosis (HP:0003128)4.14500062
19Calf muscle hypertrophy (HP:0008981)4.06017078
20Exercise-induced muscle cramps (HP:0003710)3.95883176
21Increased intramyocellular lipid droplets (HP:0012240)3.95698217
22Muscle hypertrophy of the lower extremities (HP:0008968)3.88431824
23Macrocytic anemia (HP:0001972)3.82077901
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.80742178
25Decreased activity of mitochondrial respiratory chain (HP:0008972)3.78812432
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.78812432
27Increased muscle lipid content (HP:0009058)3.75819311
28Increased serum lactate (HP:0002151)3.68508948
29Palpitations (HP:0001962)3.68209997
30Exercise-induced myalgia (HP:0003738)3.62712003
31Ventricular tachycardia (HP:0004756)3.59217838
32Optic disc pallor (HP:0000543)3.52320090
33Leukodystrophy (HP:0002415)3.45774771
34Pheochromocytoma (HP:0002666)3.40030771
35Conjunctival hamartoma (HP:0100780)3.38940266
36Myoglobinuria (HP:0002913)3.38872471
37Neuroendocrine neoplasm (HP:0100634)3.30667002
38Renal Fanconi syndrome (HP:0001994)3.21237517
39Atrial fibrillation (HP:0005110)3.14074199
40Rhabdomyolysis (HP:0003201)3.13916984
41Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.13453945
42Abnormality of the calf musculature (HP:0001430)3.09100694
43Lipoatrophy (HP:0100578)3.04668278
44Supraventricular tachycardia (HP:0004755)2.98863746
45Primary atrial arrhythmia (HP:0001692)2.95996003
46Ragged-red muscle fibers (HP:0003200)2.94020792
47Supraventricular arrhythmia (HP:0005115)2.89515338
48Pallor (HP:0000980)2.88807657
49CNS demyelination (HP:0007305)2.76930178
50Lethargy (HP:0001254)2.75608677
51Syncope (HP:0001279)2.72065243
523-Methylglutaconic aciduria (HP:0003535)2.67978232
53Respiratory difficulties (HP:0002880)2.67445616
54Aplastic anemia (HP:0001915)2.63535239
55Dicarboxylic aciduria (HP:0003215)2.61256772
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.61256772
57Emotional lability (HP:0000712)2.58316843
58Prolonged QT interval (HP:0001657)2.58287794
59Muscle fiber splitting (HP:0003555)2.55860991
60Dilated cardiomyopathy (HP:0001644)2.55789677
61Glycosuria (HP:0003076)2.54665662
62Abnormality of urine glucose concentration (HP:0011016)2.54665662
63Myotonia (HP:0002486)2.52251584
64Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.51669815
65Abnormality of alanine metabolism (HP:0010916)2.51669815
66Hyperalaninemia (HP:0003348)2.51669815
67Exertional dyspnea (HP:0002875)2.51397773
68Neoplasm of the adrenal gland (HP:0100631)2.50573447
69Abnormality of the labia minora (HP:0012880)2.44679489
70Myokymia (HP:0002411)2.42298600
71X-linked dominant inheritance (HP:0001423)2.41896679
72Colon cancer (HP:0003003)2.39053478
73Hyperglycinemia (HP:0002154)2.33773099
74EMG: myopathic abnormalities (HP:0003458)2.33026585
75Abnormality of the left ventricular outflow tract (HP:0011103)2.31070553
76Subaortic stenosis (HP:0001682)2.31070553
77Degeneration of anterior horn cells (HP:0002398)2.31034753
78Abnormality of the anterior horn cell (HP:0006802)2.31034753
79Ventricular arrhythmia (HP:0004308)2.26795446
80Ventricular fibrillation (HP:0001663)2.26101540
81Muscle stiffness (HP:0003552)2.24751080
82Abnormality of fatty-acid metabolism (HP:0004359)2.18844472
83Congenital, generalized hypertrichosis (HP:0004540)2.17052336
84Esophageal neoplasm (HP:0100751)2.16078266
85Neoplasm of head and neck (HP:0012288)2.16078266
86Right ventricular cardiomyopathy (HP:0011663)2.13767007
87Vomiting (HP:0002013)2.13589455
88Aplasia/Hypoplasia of the sacrum (HP:0008517)2.09418533
89Abnormality of renal resorption (HP:0011038)2.09304101
90Methylmalonic aciduria (HP:0012120)2.08505061
91Ketoacidosis (HP:0001993)2.07650243
92Abnormality of cells of the erythroid lineage (HP:0012130)2.07206958
93Left ventricular hypertrophy (HP:0001712)2.06166981
94Type I transferrin isoform profile (HP:0003642)2.05507865
95Hyperphosphaturia (HP:0003109)2.02181518
96Cerebral hypomyelination (HP:0006808)2.00352146
97Gliosis (HP:0002171)1.99826218
98Absent thumb (HP:0009777)1.98662488
99Generalized aminoaciduria (HP:0002909)1.98190215
100Oral leukoplakia (HP:0002745)1.98019879
101Pancreatic fibrosis (HP:0100732)1.95193629
102Hyporeflexia of lower limbs (HP:0002600)1.94586061
103Hypoplastic left heart (HP:0004383)1.94490225
104Abnormal EKG (HP:0003115)1.93552080
105Abnormality of serum amino acid levels (HP:0003112)1.93242180
106Methylmalonic acidemia (HP:0002912)1.90940225
107Neoplasm of the peripheral nervous system (HP:0100007)1.90853857
108Pancytopenia (HP:0001876)1.90148847
109Abnormal number of erythroid precursors (HP:0012131)1.90078635
110Meckel diverticulum (HP:0002245)1.88003376
111Septo-optic dysplasia (HP:0100842)1.87750690
112Hyperglycinuria (HP:0003108)1.86625731
113Progressive external ophthalmoplegia (HP:0000590)1.85003203
114Rimmed vacuoles (HP:0003805)1.84613877
115Triphalangeal thumb (HP:0001199)1.84584448
116Multiple enchondromatosis (HP:0005701)1.84301405
117Proximal tubulopathy (HP:0000114)1.83964034
118Pancreatic cysts (HP:0001737)1.82605040
119Nausea (HP:0002018)1.82352039
120Congenital malformation of the right heart (HP:0011723)1.81638601
121Double outlet right ventricle (HP:0001719)1.81638601
122Athetosis (HP:0002305)1.81260416
123Microvesicular hepatic steatosis (HP:0001414)1.80627834
124Medial flaring of the eyebrow (HP:0010747)1.80569497
125Chromosomal breakage induced by crosslinking agents (HP:0003221)1.80478417
126Stenosis of the external auditory canal (HP:0000402)1.80248086
127Metabolic acidosis (HP:0001942)1.78301096
128Hamartoma of the eye (HP:0010568)1.77604060
129Aplasia/Hypoplasia of the uvula (HP:0010293)1.76313712
130Abnormality of midbrain morphology (HP:0002418)1.76203224
131Molar tooth sign on MRI (HP:0002419)1.76203224
132Abnormality of the ileum (HP:0001549)1.75482996
133Chromsome breakage (HP:0040012)1.72704337
134True hermaphroditism (HP:0010459)1.71250415
135Blindness (HP:0000618)1.67884144
136Abnormality of methionine metabolism (HP:0010901)1.67384347
137Abnormality of aspartate family amino acid metabolism (HP:0010899)1.64711819
138Absent septum pellucidum (HP:0001331)1.64309857
139Abnormality of serine family amino acid metabolism (HP:0010894)1.62582757
140Abnormality of glycine metabolism (HP:0010895)1.62582757
141Abnormality of placental membranes (HP:0011409)1.61620174
142Amniotic constriction ring (HP:0009775)1.61620174
143Sclerocornea (HP:0000647)1.59962306
144Poor suck (HP:0002033)1.58458046
145Depressed nasal ridge (HP:0000457)1.56349437
146Abnormal lung lobation (HP:0002101)1.55785916
147Abnormality of reticulocytes (HP:0004312)1.55288112
148CNS hypomyelination (HP:0003429)1.55071020
149Megaloblastic anemia (HP:0001889)1.53544565
150Gait imbalance (HP:0002141)1.52734246

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.67264566
2VRK24.54477460
3MYLK4.42942523
4NME13.68959477
5PDK33.08173262
6PDK43.08173262
7NME22.81244948
8NEK12.76771034
9BCKDK2.75860015
10CDC72.60640087
11MAP3K122.59828709
12LMTK22.47063423
13STK242.22025836
14PHKG22.17725213
15PHKG12.17725213
16TTN2.05442529
17STK161.96256259
18PIK3CA1.86348207
19LIMK11.83672859
20WNK41.83215516
21ARAF1.78430374
22PDK21.77666187
23BUB11.76430972
24MAP4K21.75517780
25EIF2AK11.75515101
26TTK1.74352924
27NUAK11.72309776
28MUSK1.60961621
29ILK1.58801783
30STK38L1.57003421
31ZAK1.55445862
32GRK71.50238770
33BMPR1B1.37963196
34STK391.33984877
35TRIM281.33767680
36MKNK11.27566208
37PLK11.22588338
38TNIK1.18476801
39DAPK31.13125674
40GRK51.12958537
41CAMK2D1.10813650
42MAP2K71.10126084
43MAP3K41.07461382
44PLK21.06918515
45VRK11.03309380
46MST41.02388243
47PBK0.98612986
48PASK0.96246769
49TAF10.95571805
50PINK10.95438336
51DYRK30.92897801
52WEE10.92497898
53CSNK1G30.91483867
54TESK10.90708771
55BRAF0.87509732
56CASK0.87123473
57MAP2K40.85497421
58CAMK2A0.85364554
59EIF2AK30.84144283
60OXSR10.83192938
61CSNK1G20.82990511
62TLK10.82400086
63CHEK20.82151388
64ATR0.82013198
65MKNK20.79411794
66CSNK1G10.79219389
67CCNB10.78440252
68SRPK10.77962962
69INSRR0.74802980
70MINK10.74682421
71CAMK2G0.74296285
72GRK10.72299934
73PAK30.71416099
74KDR0.71274393
75WNK30.70294168
76PKN20.69421747
77ROCK10.65536708
78TSSK60.65083861
79EPHA40.64543055
80PNCK0.63242375
81BCR0.63193465
82MAP3K110.62992442
83ROCK20.61327363
84LRRK20.61022761
85TIE10.60964918
86ABL20.60137467
87ADRBK10.59123474
88CSNK1A1L0.58862879
89PRKACA0.58769823
90PIM20.57204314
91CAMK2B0.56479808
92MAPK120.54821319
93NEK20.54544701
94ERBB30.53430085
95CDC42BPA0.52418504
96DYRK20.52418496
97AURKA0.52003002
98PTK2B0.50921085
99CSNK1E0.50432641
100STK40.50338381
101MAPKAPK50.50037892
102DAPK10.48938385
103RPS6KA50.48687778
104TESK20.46041778
105PRKCG0.45588923
106PRKCE0.44800112
107UHMK10.44333454
108CSNK2A10.44119875
109CDK80.43729553
110EIF2AK20.43552810
111PLK30.42534673
112RPS6KA40.41625936
113TGFBR10.41396656
114MAPK130.41383056
115ATM0.41175601
116MAPKAPK30.39907739
117MAP2K60.38963863
118CDK140.37363217
119PRKACB0.36404557
120CDK180.35509786
121CSNK1A10.35327130
122MST1R0.35225834
123CSNK2A20.35177400
124MARK10.34859425
125PLK40.34102514
126ADRBK20.32597587
127MAP3K50.32240288
128CDK190.31973223
129AURKB0.31822595
130CDK150.31314201
131BRSK10.30109051
132RPS6KL10.29727075
133RPS6KC10.29727075
134DMPK0.29318495
135MAP2K10.28254178
136BRSK20.27695310

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.07718488
2Parkinsons disease_Homo sapiens_hsa050125.52042307
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.68261310
4Alzheimers disease_Homo sapiens_hsa050103.99242933
5Huntingtons disease_Homo sapiens_hsa050163.82449278
6Cardiac muscle contraction_Homo sapiens_hsa042603.79073495
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.43800654
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.01649981
9Proteasome_Homo sapiens_hsa030502.95077562
10Ribosome_Homo sapiens_hsa030102.69849325
11Propanoate metabolism_Homo sapiens_hsa006402.29873892
12Pyruvate metabolism_Homo sapiens_hsa006202.09992584
13Carbon metabolism_Homo sapiens_hsa012002.08611963
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88937933
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.77927436
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.62340893
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54944395
18RNA polymerase_Homo sapiens_hsa030201.47640647
19One carbon pool by folate_Homo sapiens_hsa006701.41094532
20Fatty acid degradation_Homo sapiens_hsa000711.35569426
21Butanoate metabolism_Homo sapiens_hsa006501.33408131
22Fanconi anemia pathway_Homo sapiens_hsa034601.33245635
23Fatty acid elongation_Homo sapiens_hsa000621.32887563
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.32796835
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28878589
26Collecting duct acid secretion_Homo sapiens_hsa049661.27600937
27Basal transcription factors_Homo sapiens_hsa030221.26849060
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.19944918
29Dilated cardiomyopathy_Homo sapiens_hsa054141.18438423
30Biosynthesis of amino acids_Homo sapiens_hsa012301.15674093
31Non-homologous end-joining_Homo sapiens_hsa034501.12219798
32Fatty acid metabolism_Homo sapiens_hsa012121.08532345
33Protein export_Homo sapiens_hsa030600.97654864
34Sulfur metabolism_Homo sapiens_hsa009200.96129222
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95684421
36Phenylalanine metabolism_Homo sapiens_hsa003600.89646437
37Pyrimidine metabolism_Homo sapiens_hsa002400.88891213
38* Metabolic pathways_Homo sapiens_hsa011000.82940968
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.79592540
40Vibrio cholerae infection_Homo sapiens_hsa051100.78880658
41Cell cycle_Homo sapiens_hsa041100.77554521
42Fructose and mannose metabolism_Homo sapiens_hsa000510.74265850
43Tyrosine metabolism_Homo sapiens_hsa003500.72640817
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66209389
45Peroxisome_Homo sapiens_hsa041460.63607632
46Phototransduction_Homo sapiens_hsa047440.63561931
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63030126
48Steroid biosynthesis_Homo sapiens_hsa001000.62717734
49Glutathione metabolism_Homo sapiens_hsa004800.61345565
50Nitrogen metabolism_Homo sapiens_hsa009100.59903227
51Galactose metabolism_Homo sapiens_hsa000520.58487276
52Purine metabolism_Homo sapiens_hsa002300.58398375
53beta-Alanine metabolism_Homo sapiens_hsa004100.58373145
54Arginine and proline metabolism_Homo sapiens_hsa003300.56870661
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55833337
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55207885
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54999095
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51432466
59Synaptic vesicle cycle_Homo sapiens_hsa047210.50945204
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49019862
61Selenocompound metabolism_Homo sapiens_hsa004500.48656049
62Pentose phosphate pathway_Homo sapiens_hsa000300.48382498
63Mismatch repair_Homo sapiens_hsa034300.45582342
64DNA replication_Homo sapiens_hsa030300.45508177
65Chemical carcinogenesis_Homo sapiens_hsa052040.45084299
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43139838
67Nicotine addiction_Homo sapiens_hsa050330.41105080
68Spliceosome_Homo sapiens_hsa030400.39860415
69Tryptophan metabolism_Homo sapiens_hsa003800.39390372
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39206737
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38287306
72Nucleotide excision repair_Homo sapiens_hsa034200.37316184
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.35447074
74mRNA surveillance pathway_Homo sapiens_hsa030150.34266583
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.34084405
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32433948
77Starch and sucrose metabolism_Homo sapiens_hsa005000.31031930
78Vitamin B6 metabolism_Homo sapiens_hsa007500.30882415
79Retinol metabolism_Homo sapiens_hsa008300.29734959
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29190744
81Calcium signaling pathway_Homo sapiens_hsa040200.29076878
82Linoleic acid metabolism_Homo sapiens_hsa005910.28837362
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28797473
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28092858
85PPAR signaling pathway_Homo sapiens_hsa033200.27880336
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27858614
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27295289
88Glucagon signaling pathway_Homo sapiens_hsa049220.26980166
89Regulation of autophagy_Homo sapiens_hsa041400.26405617
90RNA transport_Homo sapiens_hsa030130.25363471
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24694491
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24542647
93Vitamin digestion and absorption_Homo sapiens_hsa049770.23262944
94Homologous recombination_Homo sapiens_hsa034400.22802637
95Fat digestion and absorption_Homo sapiens_hsa049750.22621678
96RNA degradation_Homo sapiens_hsa030180.21877651
97Taste transduction_Homo sapiens_hsa047420.21652226
98Caffeine metabolism_Homo sapiens_hsa002320.21545893
99Sulfur relay system_Homo sapiens_hsa041220.21065677
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20876490
101GABAergic synapse_Homo sapiens_hsa047270.18664876
102Arachidonic acid metabolism_Homo sapiens_hsa005900.18485815
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.18416763
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.18286674
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.17534883
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.17452169
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.15834304
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.15438451
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15206625
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.14437040
111Arginine biosynthesis_Homo sapiens_hsa002200.13565611
112Basal cell carcinoma_Homo sapiens_hsa052170.13312170
113Serotonergic synapse_Homo sapiens_hsa047260.13219677
114N-Glycan biosynthesis_Homo sapiens_hsa005100.11027273
115Base excision repair_Homo sapiens_hsa034100.10935730
116Folate biosynthesis_Homo sapiens_hsa007900.10627157
117Circadian entrainment_Homo sapiens_hsa047130.10023669
118Tight junction_Homo sapiens_hsa045300.09958252
119Olfactory transduction_Homo sapiens_hsa047400.09377477
120HIF-1 signaling pathway_Homo sapiens_hsa040660.09331136
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.09306111
122Gastric acid secretion_Homo sapiens_hsa049710.09279476
123Dopaminergic synapse_Homo sapiens_hsa047280.09160993
124Viral myocarditis_Homo sapiens_hsa054160.08865700
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.08055836
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.07791080
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.07072237
128Oocyte meiosis_Homo sapiens_hsa041140.07034022
129Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.06968823
130Oxytocin signaling pathway_Homo sapiens_hsa049210.06736798

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