ATP5L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the g subunit of the Fo complex. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)9.90507258
2* respiratory electron transport chain (GO:0022904)9.02568431
3* electron transport chain (GO:0022900)8.79286528
4maturation of SSU-rRNA (GO:0030490)5.68168086
5* ATP biosynthetic process (GO:0006754)5.38410118
6translational initiation (GO:0006413)5.35510588
7* hydrogen ion transmembrane transport (GO:1902600)5.31330540
8ribosomal large subunit biogenesis (GO:0042273)5.30262449
9chaperone-mediated protein transport (GO:0072321)5.22436356
10oxidative phosphorylation (GO:0006119)5.08764558
11protein complex biogenesis (GO:0070271)5.07790021
12* purine ribonucleoside triphosphate biosynthetic process (GO:0009206)5.02485917
13* purine nucleoside triphosphate biosynthetic process (GO:0009145)4.93222048
14inner mitochondrial membrane organization (GO:0007007)4.92060265
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.87882008
16mitochondrial respiratory chain complex I assembly (GO:0032981)4.87882008
17NADH dehydrogenase complex assembly (GO:0010257)4.87882008
18establishment of protein localization to mitochondrial membrane (GO:0090151)4.84815706
19protein complex disassembly (GO:0043241)4.78468870
20protein neddylation (GO:0045116)4.68864525
21* proton transport (GO:0015992)4.67324063
22* hydrogen transport (GO:0006818)4.60024596
23macromolecular complex disassembly (GO:0032984)4.57847521
24mitochondrial respiratory chain complex assembly (GO:0033108)4.56044142
25ribosomal small subunit biogenesis (GO:0042274)4.35856706
26* ribonucleoside triphosphate biosynthetic process (GO:0009201)4.33842398
27viral transcription (GO:0019083)4.11318156
28transcription elongation from RNA polymerase III promoter (GO:0006385)4.10602221
29termination of RNA polymerase III transcription (GO:0006386)4.10602221
30nuclear-transcribed mRNA catabolic process (GO:0000956)4.01915315
31negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.97165873
32regulation of oxidative phosphorylation (GO:0002082)3.95350622
33translational termination (GO:0006415)3.91675161
34cellular component biogenesis (GO:0044085)3.87101377
35cotranslational protein targeting to membrane (GO:0006613)3.85584417
36protein targeting to ER (GO:0045047)3.82814873
37GTP biosynthetic process (GO:0006183)3.80343631
38mRNA catabolic process (GO:0006402)3.79507233
39SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.76270118
40sequestering of actin monomers (GO:0042989)3.70841815
41establishment of protein localization to endoplasmic reticulum (GO:0072599)3.69566987
42protein localization to endoplasmic reticulum (GO:0070972)3.66904823
43* nucleoside triphosphate biosynthetic process (GO:0009142)3.65821468
44positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.64187705
45ribonucleoprotein complex biogenesis (GO:0022613)3.63757528
46regulation of cellular amino acid metabolic process (GO:0006521)3.62167668
47nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.61267264
48negative regulation of ligase activity (GO:0051352)3.57648139
49negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.57648139
50energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.57622691
51ATP hydrolysis coupled proton transport (GO:0015991)3.57622691
52tricarboxylic acid cycle (GO:0006099)3.52897918
53exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.52810289
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.52565437
55aerobic respiration (GO:0009060)3.50726793
56DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.49294255
57RNA catabolic process (GO:0006401)3.44553657
58regulation of mitochondrial translation (GO:0070129)3.44113942
59signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.39078315
60signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.39078315
61signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.39078315
62rRNA modification (GO:0000154)3.38413427
63intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.37480814
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.37480814
65tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.35063710
66RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.35063710
67protein-cofactor linkage (GO:0018065)3.34994644
68anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.32935562
69deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.32533455
70* mitochondrial transport (GO:0006839)3.30551722
71* generation of precursor metabolites and energy (GO:0006091)3.30209110
72negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.30004521
73substantia nigra development (GO:0021762)3.29144378
74DNA deamination (GO:0045006)3.27660418
75water-soluble vitamin biosynthetic process (GO:0042364)3.25263570
76signal transduction involved in DNA integrity checkpoint (GO:0072401)3.25154693
77signal transduction involved in DNA damage checkpoint (GO:0072422)3.25154693
78establishment of protein localization to membrane (GO:0090150)3.22105143
79signal transduction involved in cell cycle checkpoint (GO:0072395)3.20426598
80rRNA processing (GO:0006364)3.17962470
81protein targeting (GO:0006605)3.17579482
82positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.16843883
83spliceosomal snRNP assembly (GO:0000387)3.16810949
84respiratory chain complex IV assembly (GO:0008535)3.13283170
85translational elongation (GO:0006414)3.11703251
86cullin deneddylation (GO:0010388)3.09669920
87viral life cycle (GO:0019058)3.09449833
88cellular protein complex disassembly (GO:0043624)3.08363291
89rRNA metabolic process (GO:0016072)3.05716402
90pseudouridine synthesis (GO:0001522)3.02835492
91UTP biosynthetic process (GO:0006228)3.02554660
92cytochrome complex assembly (GO:0017004)3.02345094
93positive regulation of ligase activity (GO:0051351)3.02336593
94fatty acid elongation (GO:0030497)3.02179013
95regulation of cellular respiration (GO:0043457)3.00830309
96protein targeting to mitochondrion (GO:0006626)2.98275931
97establishment of protein localization to mitochondrion (GO:0072655)2.96108759
98ubiquinone biosynthetic process (GO:0006744)2.95086289
99quinone biosynthetic process (GO:1901663)2.95086289
100central nervous system myelination (GO:0022010)2.93630782
101axon ensheathment in central nervous system (GO:0032291)2.93630782
102pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.93002757
103ribosomal small subunit assembly (GO:0000028)2.91816619
104succinate metabolic process (GO:0006105)2.89954934
105dopamine transport (GO:0015872)2.89686065
106heart process (GO:0003015)2.89357858
107heart contraction (GO:0060047)2.89357858
108* purine nucleoside monophosphate biosynthetic process (GO:0009127)2.87580586
109* purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.87580586
110positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.86124633
111protein localization to mitochondrion (GO:0070585)2.85388318
112regulation of cell communication by electrical coupling (GO:0010649)2.82550055
113regulation of acyl-CoA biosynthetic process (GO:0050812)2.82378536
114ubiquinone metabolic process (GO:0006743)2.80534390
115intracellular protein transmembrane import (GO:0044743)2.78894288
116cellular respiration (GO:0045333)2.78608968
117UTP metabolic process (GO:0046051)2.78227977
118aldehyde catabolic process (GO:0046185)2.76213044
119sarcoplasmic reticulum calcium ion transport (GO:0070296)2.74294484
120translation (GO:0006412)2.72540537
121* purine nucleoside biosynthetic process (GO:0042451)2.68771302
122* purine ribonucleoside biosynthetic process (GO:0046129)2.68771302
123cellular ketone body metabolic process (GO:0046950)2.67575974
124proteasome assembly (GO:0043248)2.66672241
125protein targeting to membrane (GO:0006612)2.64903878
126calcium-mediated signaling using intracellular calcium source (GO:0035584)2.63164823
127NADH metabolic process (GO:0006734)2.62322115
128nucleoside diphosphate phosphorylation (GO:0006165)2.62074379
129regulation of coenzyme metabolic process (GO:0051196)2.60046405
130regulation of cofactor metabolic process (GO:0051193)2.60046405
131sarcomere organization (GO:0045214)2.59760664
132dopamine biosynthetic process (GO:0042416)2.56060388
133response to epinephrine (GO:0071871)2.53549477
134regulation of dopamine metabolic process (GO:0042053)2.51587919
135regulation of catecholamine metabolic process (GO:0042069)2.51587919
136guanosine-containing compound biosynthetic process (GO:1901070)2.51007781
137negative regulation of protein localization to cell surface (GO:2000009)2.49528178
138muscle filament sliding (GO:0030049)2.47624210
139actin-myosin filament sliding (GO:0033275)2.47624210
140detection of calcium ion (GO:0005513)2.46875618
141regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.45694059
142nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.45670396
143CTP metabolic process (GO:0046036)2.44833468
144CTP biosynthetic process (GO:0006241)2.44833468
145regulation of relaxation of muscle (GO:1901077)2.43970958
146* mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.6853120
147* ATP synthesis coupled proton transport (GO:0015986)10.2179482
148* energy coupled proton transport, down electrochemical gradient (GO:0015985)10.2179482

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.27663269
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.61989107
3EZH2_22144423_ChIP-Seq_EOC_Human3.20645222
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.18441821
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11685057
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.09570674
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.98225559
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.88229619
9VDR_22108803_ChIP-Seq_LS180_Human2.87871102
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.81951470
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.79521166
12* VDR_23849224_ChIP-Seq_CD4+_Human2.75450367
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.56700950
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.52185895
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.50440271
16FOXP3_21729870_ChIP-Seq_TREG_Human2.37201303
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.34392406
18* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.31377932
19* EST1_17652178_ChIP-ChIP_JURKAT_Human2.30619674
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.26968947
21XRN2_22483619_ChIP-Seq_HELA_Human2.19702284
22TTF2_22483619_ChIP-Seq_HELA_Human2.17883032
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.16900328
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14963257
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.14454229
26TAF15_26573619_Chip-Seq_HEK293_Human2.10028336
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.04228619
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.04012058
29GBX2_23144817_ChIP-Seq_PC3_Human1.90786275
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86844716
31MYC_18940864_ChIP-ChIP_HL60_Human1.84819772
32* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84412369
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.82470299
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82046827
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.80939512
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.78307037
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77219014
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.75431119
39CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.72667949
40EZH2_27304074_Chip-Seq_ESCs_Mouse1.70140134
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.69762798
42GABP_19822575_ChIP-Seq_HepG2_Human1.65888034
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.65446539
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64490959
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.63827791
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62340777
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61474952
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60197912
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59125451
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55927554
51* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54230100
52FUS_26573619_Chip-Seq_HEK293_Human1.53048669
53* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51895799
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47246117
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47158517
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44953106
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.42740120
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.42526698
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41717464
60* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41425528
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.39505787
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39213283
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.38498426
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37788058
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.33221725
66ER_23166858_ChIP-Seq_MCF-7_Human1.32619396
67FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.31649206
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31585056
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30107204
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29287647
71P300_19829295_ChIP-Seq_ESCs_Human1.28101436
72MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26377236
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23127400
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22402601
75* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21497809
76* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18982905
77SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18728852
78RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18232532
79EZH2_18974828_ChIP-Seq_MESCs_Mouse1.17183098
80RNF2_18974828_ChIP-Seq_MESCs_Mouse1.17183098
81CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16798021
82* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16477712
83SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16408834
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16369866
85ELK1_19687146_ChIP-ChIP_HELA_Human1.14086018
86EZH2_27294783_Chip-Seq_ESCs_Mouse1.13906620
87EWS_26573619_Chip-Seq_HEK293_Human1.13876958
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13656266
89* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12373365
90POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11682802
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10685323
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10456082
93EP300_21415370_ChIP-Seq_HL-1_Mouse1.10000620
94TP53_22573176_ChIP-Seq_HFKS_Human1.08436702
95HTT_18923047_ChIP-ChIP_STHdh_Human1.07893856
96CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07805120
97YY1_21170310_ChIP-Seq_MESCs_Mouse1.04750569
98NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00370638
99ZNF274_21170338_ChIP-Seq_K562_Hela0.99390025
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98916209
101* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98478625
102HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97720376
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96397318
104SOX2_16153702_ChIP-ChIP_HESCs_Human0.96361095
105THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95763351
106NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95619842
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94527081
108* DCP1A_22483619_ChIP-Seq_HELA_Human0.94452879
109EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94253240
110PIAS1_25552417_ChIP-Seq_VCAP_Human0.94178452
111* REST_21632747_ChIP-Seq_MESCs_Mouse0.93911201
112POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93529804
113TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91680071
114PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91505294
115SOX2_19829295_ChIP-Seq_ESCs_Human0.91122639
116NANOG_19829295_ChIP-Seq_ESCs_Human0.91122639
117CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90807231
118ERG_20517297_ChIP-Seq_VCAP_Human0.90670626
119* KDM5A_27292631_Chip-Seq_BREAST_Human0.90549976
120CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90135598
121CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89989570
122IGF1R_20145208_ChIP-Seq_DFB_Human0.88573903
123AR_20517297_ChIP-Seq_VCAP_Human0.88092570
124SMAD3_21741376_ChIP-Seq_EPCs_Human0.87640746
125FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87487905
126FOXA1_25329375_ChIP-Seq_VCAP_Human0.87487905
127REST_19997604_ChIP-ChIP_NEURONS_Mouse0.87336412
128NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87138714
129* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.86225632
130PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86206302
131SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86044775
132BCAT_22108803_ChIP-Seq_LS180_Human0.84884498
133NANOG_16153702_ChIP-ChIP_HESCs_Human0.83674712
134KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82763369
135PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.81258243
136FLI1_27457419_Chip-Seq_LIVER_Mouse0.79998986
137TAL1_26923725_Chip-Seq_HPCs_Mouse0.79964742
138* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.79695391
139JUN_21703547_ChIP-Seq_K562_Human0.79164170
140* REST_18959480_ChIP-ChIP_MESCs_Mouse0.78965649
141E2F7_22180533_ChIP-Seq_HELA_Human0.78585403
142* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78031704
143NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77279120
144NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77279120
145* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.77155006
146CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.75963385
147EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.75569362
148BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.74942917
149NCOR_22424771_ChIP-Seq_293T_Human0.74735118
150ERG_20887958_ChIP-Seq_HPC-7_Mouse0.74629422
151ELF5_23300383_ChIP-Seq_T47D_Human0.71136221
152* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.68358984
153NANOG_20526341_ChIP-Seq_ESCs_Human0.67708236
154* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.67279355
155NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.66213738

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.35671695
2MP0003880_abnormal_central_pattern3.63069851
3MP0009379_abnormal_foot_pigmentation3.56650417
4MP0001529_abnormal_vocalization3.42263107
5MP0003646_muscle_fatigue3.05204265
6MP0006292_abnormal_olfactory_placode2.81705508
7MP0006036_abnormal_mitochondrial_physio2.75663492
8MP0000751_myopathy2.69605344
9MP0004215_abnormal_myocardial_fiber2.65161004
10MP0001905_abnormal_dopamine_level2.41801399
11MP0006276_abnormal_autonomic_nervous2.29785077
12MP0004036_abnormal_muscle_relaxation2.28176983
13MP0002938_white_spotting2.26765491
14MP0000749_muscle_degeneration2.16188992
15MP0004084_abnormal_cardiac_muscle2.14770204
16MP0008995_early_reproductive_senescence2.12276793
17MP0008058_abnormal_DNA_repair2.12071727
18MP0006035_abnormal_mitochondrial_morpho2.07076082
19MP0005330_cardiomyopathy2.04774031
20MP0005084_abnormal_gallbladder_morpholo1.98989224
21MP0003195_calcinosis1.96312818
22MP0004043_abnormal_pH_regulation1.92054560
23MP0002277_abnormal_respiratory_mucosa1.89913564
24MP0003786_premature_aging1.82673889
25MP0003011_delayed_dark_adaptation1.80973316
26MP0004142_abnormal_muscle_tone1.77526862
27MP0003718_maternal_effect1.76946712
28MP0003137_abnormal_impulse_conducting1.75939884
29MP0001440_abnormal_grooming_behavior1.71675705
30MP0002972_abnormal_cardiac_muscle1.68650193
31MP0004145_abnormal_muscle_electrophysio1.66717928
32MP0003136_yellow_coat_color1.64274696
33MP0004484_altered_response_of1.61459537
34MP0002272_abnormal_nervous_system1.60528899
35MP0004957_abnormal_blastocyst_morpholog1.58331470
36MP0002102_abnormal_ear_morphology1.58151655
37MP0002638_abnormal_pupillary_reflex1.57363483
38MP0009745_abnormal_behavioral_response1.56368642
39MP0005379_endocrine/exocrine_gland_phen1.51718540
40MP0003693_abnormal_embryo_hatching1.51569943
41MP0002064_seizures1.50513323
42MP0005620_abnormal_muscle_contractility1.47228616
43MP0002736_abnormal_nociception_after1.44426140
44MP0002332_abnormal_exercise_endurance1.44165880
45MP0005645_abnormal_hypothalamus_physiol1.43767491
46MP0008877_abnormal_DNA_methylation1.43511447
47MP0002822_catalepsy1.42219322
48MP0009046_muscle_twitch1.39109532
49MP0001968_abnormal_touch/_nociception1.38794726
50MP0010386_abnormal_urinary_bladder1.38215001
51MP0005535_abnormal_body_temperature1.36147759
52MP0005646_abnormal_pituitary_gland1.35558065
53MP0004924_abnormal_behavior1.34924253
54MP0005386_behavior/neurological_phenoty1.34924253
55MP0004085_abnormal_heartbeat1.33666461
56MP0005671_abnormal_response_to1.31218790
57MP0003186_abnormal_redox_activity1.30926400
58MP0000920_abnormal_myelination1.30910164
59MP0004270_analgesia1.28806927
60MP0000750_abnormal_muscle_regeneration1.28167553
61MP0002163_abnormal_gland_morphology1.27561636
62MP0002106_abnormal_muscle_physiology1.27460684
63MP0001727_abnormal_embryo_implantation1.26098889
64MP0002572_abnormal_emotion/affect_behav1.25456498
65MP0008789_abnormal_olfactory_epithelium1.25021593
66MP0003635_abnormal_synaptic_transmissio1.23342544
67MP0002734_abnormal_mechanical_nocicepti1.22729456
68MP0000013_abnormal_adipose_tissue1.22180328
69MP0001501_abnormal_sleep_pattern1.21889279
70MP0003806_abnormal_nucleotide_metabolis1.21330286
71MP0001486_abnormal_startle_reflex1.18656347
72MP0002095_abnormal_skin_pigmentation1.18474544
73MP0005075_abnormal_melanosome_morpholog1.17761784
74MP0006072_abnormal_retinal_apoptosis1.17435938
75MP0001764_abnormal_homeostasis1.16308049
76MP0005636_abnormal_mineral_homeostasis1.16119046
77MP0001485_abnormal_pinna_reflex1.16079905
78MP0002735_abnormal_chemical_nociception1.15880099
79MP0001970_abnormal_pain_threshold1.15466335
80MP0008775_abnormal_heart_ventricle1.13635394
81MP0000631_abnormal_neuroendocrine_gland1.12983921
82MP0003329_amyloid_beta_deposits1.12804921
83MP0005253_abnormal_eye_physiology1.11783371
84MP0010094_abnormal_chromosome_stability1.11479512
85MP0001293_anophthalmia1.11381496
86MP0004742_abnormal_vestibular_system1.11311204
87MP0001544_abnormal_cardiovascular_syste1.10825085
88MP0005385_cardiovascular_system_phenoty1.10825085
89MP0010030_abnormal_orbit_morphology1.09910938
90MP0000747_muscle_weakness1.08572446
91MP0005369_muscle_phenotype1.08475906
92MP0000230_abnormal_systemic_arterial1.08471680
93MP0009697_abnormal_copulation1.08279942
94MP0002067_abnormal_sensory_capabilities1.06043224
95MP0005377_hearing/vestibular/ear_phenot1.05393796
96MP0003878_abnormal_ear_physiology1.05393796
97MP0005389_reproductive_system_phenotype1.03640393
98MP0001919_abnormal_reproductive_system1.03505063
99MP0004885_abnormal_endolymph1.02820067
100MP0004133_heterotaxia1.02762886
101MP0002160_abnormal_reproductive_system1.02177123
102MP0002733_abnormal_thermal_nociception1.00901792
103MP0003950_abnormal_plasma_membrane1.00771454
104MP0008932_abnormal_embryonic_tissue0.98988196
105MP0002063_abnormal_learning/memory/cond0.98777438
106MP0002132_abnormal_respiratory_system0.98660991
107MP0006138_congestive_heart_failure0.98538820
108MP0004087_abnormal_muscle_fiber0.98537562
109MP0001984_abnormal_olfaction0.97902742
110MP0005332_abnormal_amino_acid0.97806639
111MP0005451_abnormal_body_composition0.97750831
112MP0003938_abnormal_ear_development0.97236787
113MP0002653_abnormal_ependyma_morphology0.97000003
114MP0002876_abnormal_thyroid_physiology0.96249874
115MP0001188_hyperpigmentation0.93793084
116MP0005165_increased_susceptibility_to0.93147342
117MP0005409_darkened_coat_color0.91479618
118MP0003315_abnormal_perineum_morphology0.90823114
119MP0003077_abnormal_cell_cycle0.90751214
120MP0005551_abnormal_eye_electrophysiolog0.90234713
121MP0004019_abnormal_vitamin_homeostasis0.88249676
122MP0002210_abnormal_sex_determination0.88088991
123MP0004130_abnormal_muscle_cell0.87851742
124MP0000759_abnormal_skeletal_muscle0.87599262
125MP0005266_abnormal_metabolism0.86576927
126MP0005171_absent_coat_pigmentation0.86557808
127MP0001765_abnormal_ion_homeostasis0.86359639
128MP0008875_abnormal_xenobiotic_pharmacok0.86196636
129MP0000372_irregular_coat_pigmentation0.86087443
130MP0005408_hypopigmentation0.85949125
131MP0004147_increased_porphyrin_level0.85943308
132MP0008007_abnormal_cellular_replicative0.85182747
133MP0002229_neurodegeneration0.82546360
134MP0005083_abnormal_biliary_tract0.81859856
135MP0002234_abnormal_pharynx_morphology0.80507141
136MP0003638_abnormal_response/metabolism_0.79685924
137MP0005423_abnormal_somatic_nervous0.78481261
138MP0003121_genomic_imprinting0.76444264
139MP0000026_abnormal_inner_ear0.76425641
140MP0003123_paternal_imprinting0.75638434
141MP0002066_abnormal_motor_capabilities/c0.75362255
142MP0001986_abnormal_taste_sensitivity0.74126418
143MP0003567_abnormal_fetal_cardiomyocyte0.73616395
144MP0005410_abnormal_fertilization0.73352736
145MP0002127_abnormal_cardiovascular_syste0.73103039
146MP0002090_abnormal_vision0.72886849
147MP0002184_abnormal_innervation0.72666794
148MP0003221_abnormal_cardiomyocyte_apopto0.72106533
149MP0005174_abnormal_tail_pigmentation0.71468763
150MP0001664_abnormal_digestion0.70993405
151MP0008872_abnormal_physiological_respon0.70861898
152MP0002295_abnormal_pulmonary_circulatio0.70290713
153MP0009333_abnormal_splenocyte_physiolog0.67380341
154MP0003283_abnormal_digestive_organ0.67343874
155MP0003787_abnormal_imprinting0.67215449
156MP0000049_abnormal_middle_ear0.65558937
157MP0000653_abnormal_sex_gland0.65538683
158MP0003941_abnormal_skin_development0.65306287
159MP0005195_abnormal_posterior_eye0.65005618

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.79132171
2Abnormal mitochondria in muscle tissue (HP:0008316)7.15448971
3Mitochondrial inheritance (HP:0001427)6.65083713
4Progressive macrocephaly (HP:0004481)6.61768709
5Acute encephalopathy (HP:0006846)6.59727472
6Increased CSF lactate (HP:0002490)5.62979120
7Hepatocellular necrosis (HP:0001404)5.52262914
8Increased hepatocellular lipid droplets (HP:0006565)5.32462365
9Hepatic necrosis (HP:0002605)5.23460705
10Lipid accumulation in hepatocytes (HP:0006561)4.98388553
11Cerebral edema (HP:0002181)4.93248013
12Renal Fanconi syndrome (HP:0001994)4.62512112
13Increased intramyocellular lipid droplets (HP:0012240)4.51677727
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.19981319
15Exercise intolerance (HP:0003546)4.09971601
16Increased muscle lipid content (HP:0009058)4.09846605
17Increased serum pyruvate (HP:0003542)4.08988496
18Abnormality of glycolysis (HP:0004366)4.08988496
19Respiratory failure (HP:0002878)4.05992755
20Optic disc pallor (HP:0000543)3.99177446
21Lactic acidosis (HP:0003128)3.93698775
22Leukodystrophy (HP:0002415)3.79275695
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.79256358
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.79256358
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.65662776
263-Methylglutaconic aciduria (HP:0003535)3.49757885
27Exertional dyspnea (HP:0002875)3.42460640
28Increased serum lactate (HP:0002151)3.26731220
29Pallor (HP:0000980)3.20113033
30Congenital, generalized hypertrichosis (HP:0004540)3.17157228
31Abnormality of renal resorption (HP:0011038)3.14839838
32Muscle hypertrophy of the lower extremities (HP:0008968)3.09920023
33Calf muscle hypertrophy (HP:0008981)3.04993201
34Neuroendocrine neoplasm (HP:0100634)3.02083279
35Pheochromocytoma (HP:0002666)3.00176351
36Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.98313501
37Respiratory difficulties (HP:0002880)2.93486581
38Glycosuria (HP:0003076)2.88632049
39Abnormality of urine glucose concentration (HP:0011016)2.88632049
40Sudden death (HP:0001699)2.85686713
41Aplastic anemia (HP:0001915)2.78105394
42X-linked dominant inheritance (HP:0001423)2.74245672
43Abnormality of cells of the erythroid lineage (HP:0012130)2.72223230
44Hyperphosphaturia (HP:0003109)2.69501218
45Parakeratosis (HP:0001036)2.62254802
46Lethargy (HP:0001254)2.56840696
47Palpitations (HP:0001962)2.43352670
48Conjunctival hamartoma (HP:0100780)2.40184843
49CNS demyelination (HP:0007305)2.40139535
50Type I transferrin isoform profile (HP:0003642)2.39812287
51Abnormal number of erythroid precursors (HP:0012131)2.35419915
52Oral leukoplakia (HP:0002745)2.32666368
53Abnormal urine phosphate concentration (HP:0012599)2.31582379
54Abnormality of midbrain morphology (HP:0002418)2.31517972
55Molar tooth sign on MRI (HP:0002419)2.31517972
56Pancreatic cysts (HP:0001737)2.28968888
57Exercise-induced myalgia (HP:0003738)2.25090497
58Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23182528
59Dicarboxylic aciduria (HP:0003215)2.23072712
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.23072712
61Pancreatic fibrosis (HP:0100732)2.22765301
62Emotional lability (HP:0000712)2.15448721
63Ketoacidosis (HP:0001993)2.13391943
64Vomiting (HP:0002013)2.11648412
65Cerebral hemorrhage (HP:0001342)2.11583475
66True hermaphroditism (HP:0010459)2.11434719
67Methylmalonic aciduria (HP:0012120)2.08319014
68Muscle fiber splitting (HP:0003555)2.07810483
69Abnormality of the calf musculature (HP:0001430)2.07679338
70Macrocytic anemia (HP:0001972)2.06564836
71Congenital ichthyosiform erythroderma (HP:0007431)2.06150300
72Renal tubular dysfunction (HP:0000124)2.03559669
73Ventricular tachycardia (HP:0004756)2.03374506
74Methylmalonic acidemia (HP:0002912)2.01930262
75Abnormal pupillary function (HP:0007686)2.01472064
76Generalized aminoaciduria (HP:0002909)2.00704681
77Pancytopenia (HP:0001876)1.96425640
78Myoglobinuria (HP:0002913)1.93170166
79Degeneration of anterior horn cells (HP:0002398)1.87471624
80Abnormality of the anterior horn cell (HP:0006802)1.87471624
81Absent thumb (HP:0009777)1.87462430
82Septo-optic dysplasia (HP:0100842)1.84959846
83Nephronophthisis (HP:0000090)1.84800905
84Exercise-induced muscle cramps (HP:0003710)1.82114693
85Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81399240
86Syncope (HP:0001279)1.80389214
87Sclerocornea (HP:0000647)1.80338227
88Abnormality of serum amino acid levels (HP:0003112)1.80130406
89Renal cortical cysts (HP:0000803)1.79679279
90Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78590690
91Abnormal protein N-linked glycosylation (HP:0012347)1.78590690
92Abnormal protein glycosylation (HP:0012346)1.78590690
93Abnormal glycosylation (HP:0012345)1.78590690
94Megaloblastic anemia (HP:0001889)1.78511316
95Medial flaring of the eyebrow (HP:0010747)1.77977401
96Hypoglycemic coma (HP:0001325)1.77820918
97Colon cancer (HP:0003003)1.77807858
98Hyperglycinemia (HP:0002154)1.77749047
99Abnormality of alanine metabolism (HP:0010916)1.76089750
100Hyperalaninemia (HP:0003348)1.76089750
101Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76089750
102Abnormality of methionine metabolism (HP:0010901)1.75894370
103Congenital stationary night blindness (HP:0007642)1.74862332
104Lipoatrophy (HP:0100578)1.74782011
105Stenosis of the external auditory canal (HP:0000402)1.73640392
106Abnormality of fatty-acid metabolism (HP:0004359)1.73499396
107Myotonia (HP:0002486)1.73237087
108Prolonged QT interval (HP:0001657)1.71411392
109Gliosis (HP:0002171)1.68734370
110Atrial fibrillation (HP:0005110)1.68474046
111Muscle stiffness (HP:0003552)1.68404248
112Microvesicular hepatic steatosis (HP:0001414)1.68296962
113Rhabdomyolysis (HP:0003201)1.67231163
114Reticulocytopenia (HP:0001896)1.66960877
115Blindness (HP:0000618)1.66691111
116Testicular atrophy (HP:0000029)1.66113342
117Myokymia (HP:0002411)1.65668785
118Hypothermia (HP:0002045)1.65200332
119Ragged-red muscle fibers (HP:0003200)1.65135257
120Pendular nystagmus (HP:0012043)1.64440088
121Sensory axonal neuropathy (HP:0003390)1.63313222
122Abnormality of vitamin B metabolism (HP:0004340)1.63304064
123Abnormality of the renal cortex (HP:0011035)1.63273291
124Dilated cardiomyopathy (HP:0001644)1.62110240
125Aplasia/hypoplasia of the uterus (HP:0008684)1.61911189
126Amniotic constriction ring (HP:0009775)1.61552078
127Abnormality of placental membranes (HP:0011409)1.61552078
128Nausea (HP:0002018)1.61346912
129Sparse eyelashes (HP:0000653)1.61234874
130Depressed nasal ridge (HP:0000457)1.61210943
131Supraventricular tachycardia (HP:0004755)1.61083776
132Esophageal neoplasm (HP:0100751)1.61047299
133Neoplasm of head and neck (HP:0012288)1.61047299
134Ketosis (HP:0001946)1.61027890
135Metabolic acidosis (HP:0001942)1.60159058
136Primary atrial arrhythmia (HP:0001692)1.59922228
137EMG: myopathic abnormalities (HP:0003458)1.58150085
138Concave nail (HP:0001598)1.57681566
139Abnormal hemoglobin (HP:0011902)1.54753823
140Abnormality of the vitamin B12 metabolism (HP:0004341)1.53835738
141Supraventricular arrhythmia (HP:0005115)1.53172037
142Hypoplastic left heart (HP:0004383)1.52227500
143Rimmed vacuoles (HP:0003805)1.50613774

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.08614216
2NME13.59479495
3NME23.32749204
4STK393.16830494
5BUB13.13113463
6MYLK3.04711230
7MAP3K122.97914213
8WNK42.74236488
9GRK72.68995127
10ZAK2.58448287
11OBSCN2.52806652
12MUSK2.52654426
13OXSR12.43983959
14PBK2.31128874
15MST42.26095902
16ARAF2.25154482
17CDC71.97612759
18STK161.97379360
19PNCK1.81217606
20SRPK11.78766168
21CASK1.78538712
22TESK21.76272887
23NUAK11.73248882
24BCKDK1.72809123
25BCR1.61256707
26PASK1.60575022
27GRK51.59494070
28TNIK1.55564722
29MAP4K21.54691656
30WNK31.48620967
31LIMK11.44149366
32RIPK41.44140456
33TAF11.43101491
34NEK11.42262506
35PHKG11.40127439
36PHKG21.40127439
37CDK191.36681134
38MAPK151.36232254
39CAMK2D1.35473874
40EIF2AK11.33442753
41BMPR21.30733796
42KDR1.28731209
43MAP2K71.25487626
44MAPKAPK51.25398507
45VRK11.21950949
46EPHA41.20062356
47CAMK2B1.19457596
48PLK41.19378321
49ADRBK21.18350622
50CAMK2A1.17936491
51LMTK21.17006801
52TXK1.15752985
53UHMK11.15722102
54PLK31.15394461
55PKN11.12700789
56BMPR1B1.10667701
57PIK3CA1.06528620
58ABL21.06300121
59PDK41.01934087
60PDK31.01934087
61ADRBK11.00671337
62ILK0.99965341
63PINK10.99666011
64TESK10.97578109
65TTN0.94584234
66ROCK20.93756115
67PIK3CG0.93405068
68FGR0.92751585
69MST1R0.91748081
70CAMK2G0.91721103
71PRKCE0.91201615
72WEE10.91176788
73AURKB0.88364337
74DAPK30.85660806
75PAK30.85460085
76MAP3K40.83742545
77LRRK20.81455116
78DYRK20.81311096
79PDK20.80903183
80PLK10.78262245
81TLK10.75486047
82CSNK1G30.75050920
83DAPK10.74971385
84CSNK2A10.73933025
85EIF2AK30.73872871
86NTRK30.73211094
87PRKACA0.72915610
88PLK20.70855087
89TTK0.70411664
90MARK10.69926371
91MAP2K40.67303401
92CDK80.66402779
93PIM20.65573575
94PTK2B0.65500346
95TRIM280.64784689
96EPHB20.64736666
97AURKA0.63954331
98BRAF0.63933410
99MAPK130.63747698
100INSRR0.63628917
101CCNB10.62324645
102BRSK20.58857324
103TAOK30.57449271
104DYRK30.57424972
105TIE10.54664157
106CHEK20.52470578
107MKNK10.49951905
108PRKCQ0.48891804
109MOS0.48840997
110IKBKB0.47429942
111NTRK10.47008195
112STK40.45970538
113PRKCG0.44909432
114ITK0.43111479
115CSNK1G20.42994422
116MAPK120.42798507
117TEC0.42625000
118GRK60.42330705
119RPS6KB20.42320574
120MAPKAPK30.42220474
121BRSK10.41528322
122WNK10.41237040
123CDK30.40578200
124PRKCI0.39580525
125ATR0.39298167
126FRK0.38489220
127CDK50.38360538
128ROCK10.38308779
129PRKG10.37557588
130CDK140.36888323
131STK240.36774437
132PRKD10.36581167
133CSNK1A10.36110619
134CSNK1G10.36012314
135MINK10.35223971
136MET0.34103673
137PRKCA0.32992500
138CSNK1E0.32801723
139GRK10.32777589
140ERBB30.32447451
141EIF2AK20.32017594
142MAPK40.30569318
143RPS6KA50.30184104
144IRAK20.29233352
145PRKACG0.29046017
146MAP2K10.28268482
147CSNK2A20.27840303

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.83804828
2Parkinsons disease_Homo sapiens_hsa050125.88725464
3Alzheimers disease_Homo sapiens_hsa050104.62535132
4Huntingtons disease_Homo sapiens_hsa050164.08176029
5Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.90291936
6Cardiac muscle contraction_Homo sapiens_hsa042603.43446502
7Ribosome_Homo sapiens_hsa030103.30988098
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.49563840
9Protein export_Homo sapiens_hsa030602.42180142
10Proteasome_Homo sapiens_hsa030502.33701906
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28479807
12Mismatch repair_Homo sapiens_hsa034302.15483600
13Fatty acid elongation_Homo sapiens_hsa000622.01905190
14Homologous recombination_Homo sapiens_hsa034402.00365004
15Sulfur metabolism_Homo sapiens_hsa009201.97807539
16DNA replication_Homo sapiens_hsa030301.95090066
17Collecting duct acid secretion_Homo sapiens_hsa049661.86534140
18Propanoate metabolism_Homo sapiens_hsa006401.75079565
19Spliceosome_Homo sapiens_hsa030401.59051406
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57630801
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.55299511
22Nucleotide excision repair_Homo sapiens_hsa034201.43413490
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39910240
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39618372
25Butanoate metabolism_Homo sapiens_hsa006501.36447226
26Pyruvate metabolism_Homo sapiens_hsa006201.35268461
27One carbon pool by folate_Homo sapiens_hsa006701.26557697
28Vibrio cholerae infection_Homo sapiens_hsa051101.23440755
29RNA degradation_Homo sapiens_hsa030181.21487595
30RNA polymerase_Homo sapiens_hsa030201.19868501
31Base excision repair_Homo sapiens_hsa034101.16734712
32Basal transcription factors_Homo sapiens_hsa030221.09247348
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04945939
34Fanconi anemia pathway_Homo sapiens_hsa034601.01079803
35Carbon metabolism_Homo sapiens_hsa012000.94526915
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93828962
37RNA transport_Homo sapiens_hsa030130.91624077
38Tyrosine metabolism_Homo sapiens_hsa003500.88595178
39Phenylalanine metabolism_Homo sapiens_hsa003600.85959461
40* Metabolic pathways_Homo sapiens_hsa011000.85494822
41Fatty acid degradation_Homo sapiens_hsa000710.83466407
42Nicotine addiction_Homo sapiens_hsa050330.82412734
43Peroxisome_Homo sapiens_hsa041460.80885943
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79905520
45Fatty acid metabolism_Homo sapiens_hsa012120.75208007
46Asthma_Homo sapiens_hsa053100.73791155
47Serotonergic synapse_Homo sapiens_hsa047260.73460558
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72677192
49Rheumatoid arthritis_Homo sapiens_hsa053230.71299532
50Glutathione metabolism_Homo sapiens_hsa004800.71171714
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67902159
52Steroid biosynthesis_Homo sapiens_hsa001000.67092446
53Nitrogen metabolism_Homo sapiens_hsa009100.66010959
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63896125
55Ether lipid metabolism_Homo sapiens_hsa005650.61416676
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59485594
57Synaptic vesicle cycle_Homo sapiens_hsa047210.58312571
58Linoleic acid metabolism_Homo sapiens_hsa005910.57672903
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.55257981
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54671415
61Arginine and proline metabolism_Homo sapiens_hsa003300.54494555
62Primary immunodeficiency_Homo sapiens_hsa053400.54178709
63Histidine metabolism_Homo sapiens_hsa003400.53742955
64Taste transduction_Homo sapiens_hsa047420.53235038
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53116687
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52508507
67GABAergic synapse_Homo sapiens_hsa047270.52477612
68Caffeine metabolism_Homo sapiens_hsa002320.52433520
69Dilated cardiomyopathy_Homo sapiens_hsa054140.51964840
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.51594746
71Arachidonic acid metabolism_Homo sapiens_hsa005900.51531356
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51238868
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51207504
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50182788
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48810136
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.48375467
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47145389
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45716051
79beta-Alanine metabolism_Homo sapiens_hsa004100.45218699
80Pyrimidine metabolism_Homo sapiens_hsa002400.42668284
81Chemical carcinogenesis_Homo sapiens_hsa052040.42138569
82Autoimmune thyroid disease_Homo sapiens_hsa053200.41945009
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.40436303
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40429795
85Retinol metabolism_Homo sapiens_hsa008300.40301777
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40238545
87Allograft rejection_Homo sapiens_hsa053300.40124515
88Phototransduction_Homo sapiens_hsa047440.40085167
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40056170
90Phagosome_Homo sapiens_hsa041450.38547393
91Systemic lupus erythematosus_Homo sapiens_hsa053220.38387827
92Tryptophan metabolism_Homo sapiens_hsa003800.36689998
93Selenocompound metabolism_Homo sapiens_hsa004500.36364430
94Calcium signaling pathway_Homo sapiens_hsa040200.34751439
95Vitamin digestion and absorption_Homo sapiens_hsa049770.34387991
96Antigen processing and presentation_Homo sapiens_hsa046120.32947668
97Morphine addiction_Homo sapiens_hsa050320.31899901
98Renin secretion_Homo sapiens_hsa049240.31804314
99Non-homologous end-joining_Homo sapiens_hsa034500.30839912
100Amphetamine addiction_Homo sapiens_hsa050310.30306175
101Glutamatergic synapse_Homo sapiens_hsa047240.28823927
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28653524
103Circadian entrainment_Homo sapiens_hsa047130.28323183
104PPAR signaling pathway_Homo sapiens_hsa033200.27376597
105Dopaminergic synapse_Homo sapiens_hsa047280.26214811
106Purine metabolism_Homo sapiens_hsa002300.26028460
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25522627
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.24490275
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23334964
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.23086007
111Folate biosynthesis_Homo sapiens_hsa007900.22490235
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22025699
113Epstein-Barr virus infection_Homo sapiens_hsa051690.21993183
114Olfactory transduction_Homo sapiens_hsa047400.21725856
115Cocaine addiction_Homo sapiens_hsa050300.20797376
116Cell cycle_Homo sapiens_hsa041100.20064695
117Long-term depression_Homo sapiens_hsa047300.19973482
118Pancreatic secretion_Homo sapiens_hsa049720.19149162
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.19047705
120Salivary secretion_Homo sapiens_hsa049700.18858500
121Gastric acid secretion_Homo sapiens_hsa049710.18823506
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.18437329
123Sphingolipid metabolism_Homo sapiens_hsa006000.18360279
124Graft-versus-host disease_Homo sapiens_hsa053320.17661546
125Insulin secretion_Homo sapiens_hsa049110.17344831
126Cholinergic synapse_Homo sapiens_hsa047250.16022429
127Regulation of autophagy_Homo sapiens_hsa041400.15907480
128N-Glycan biosynthesis_Homo sapiens_hsa005100.15761726
129Steroid hormone biosynthesis_Homo sapiens_hsa001400.15475143
130Sulfur relay system_Homo sapiens_hsa041220.13944393
131Fat digestion and absorption_Homo sapiens_hsa049750.13567077
132Type I diabetes mellitus_Homo sapiens_hsa049400.12983476
133Long-term potentiation_Homo sapiens_hsa047200.12086762
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11334582
135Mineral absorption_Homo sapiens_hsa049780.11087499
136Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.10932961
137Starch and sucrose metabolism_Homo sapiens_hsa005000.10007314

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