ATP5HP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)7.89984845
2DNA deamination (GO:0045006)7.34510515
3ribosomal small subunit biogenesis (GO:0042274)7.11188276
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.91097876
5ribosomal small subunit assembly (GO:0000028)6.14468569
6ATP synthesis coupled proton transport (GO:0015986)5.77323784
7energy coupled proton transport, down electrochemical gradient (GO:0015985)5.77323784
8establishment of protein localization to mitochondrial membrane (GO:0090151)5.68513768
9viral transcription (GO:0019083)5.55990747
10cytidine metabolic process (GO:0046087)5.35649848
11cytidine catabolic process (GO:0006216)5.35649848
12cytidine deamination (GO:0009972)5.35649848
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.35444828
14translational termination (GO:0006415)5.30360432
15cell wall macromolecule catabolic process (GO:0016998)5.21249478
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.93467781
17cotranslational protein targeting to membrane (GO:0006613)4.81423468
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.80211316
19protein targeting to ER (GO:0045047)4.76982465
20chaperone-mediated protein transport (GO:0072321)4.67225401
21establishment of protein localization to endoplasmic reticulum (GO:0072599)4.58909401
22protein localization to endoplasmic reticulum (GO:0070972)4.48635029
23pyrimidine ribonucleoside catabolic process (GO:0046133)4.41432414
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.40703518
25mitochondrial respiratory chain complex I assembly (GO:0032981)4.40703518
26NADH dehydrogenase complex assembly (GO:0010257)4.40703518
27translational elongation (GO:0006414)4.40111396
28cell wall macromolecule metabolic process (GO:0044036)4.34022131
29cardiovascular system development (GO:0072358)4.31976954
30viral life cycle (GO:0019058)4.16967896
31electron transport chain (GO:0022900)4.10403885
32respiratory electron transport chain (GO:0022904)4.09708338
33pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.03708018
34proteasome assembly (GO:0043248)4.02654594
35cellular protein complex disassembly (GO:0043624)3.98571263
36translational initiation (GO:0006413)3.93912923
37DNA demethylation (GO:0080111)3.89228627
38protein complex biogenesis (GO:0070271)3.88605232
39nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.73771686
40organic cation transport (GO:0015695)3.72837037
41exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.71539144
42mitochondrial respiratory chain complex assembly (GO:0033108)3.70462904
43nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.67117438
44translation (GO:0006412)3.63583401
45DNA dealkylation (GO:0035510)3.54446474
46peptidyl-histidine modification (GO:0018202)3.52656338
47respiratory chain complex IV assembly (GO:0008535)3.47866999
48behavioral response to nicotine (GO:0035095)3.40238237
49water-soluble vitamin biosynthetic process (GO:0042364)3.36521811
50ribosomal large subunit biogenesis (GO:0042273)3.35573923
51cellular component biogenesis (GO:0044085)3.35059527
52cellular response to interferon-beta (GO:0035458)3.31685115
53ATP biosynthetic process (GO:0006754)3.30437927
54intracellular protein transmembrane import (GO:0044743)3.25394342
55ribonucleoprotein complex biogenesis (GO:0022613)3.24318993
56positive regulation of defense response to virus by host (GO:0002230)3.21124715
57protein complex disassembly (GO:0043241)3.19888211
58hydrogen ion transmembrane transport (GO:1902600)3.17400598
59antigen processing and presentation via MHC class Ib (GO:0002475)3.14046472
60macromolecular complex disassembly (GO:0032984)3.13918445
61pyrimidine nucleotide catabolic process (GO:0006244)3.13682184
62protein neddylation (GO:0045116)3.12502937
63valine metabolic process (GO:0006573)3.10017937
64viral protein processing (GO:0019082)3.09586271
65purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.08757562
66purine nucleoside triphosphate biosynthetic process (GO:0009145)3.08373032
67cellular ketone body metabolic process (GO:0046950)3.06927240
68base-excision repair, AP site formation (GO:0006285)3.05622365
69protein targeting to membrane (GO:0006612)3.03182846
70nuclear-transcribed mRNA catabolic process (GO:0000956)3.01802811
71UTP metabolic process (GO:0046051)2.97748094
72proton transport (GO:0015992)2.97145139
73hydrogen transport (GO:0006818)2.97039065
74ncRNA 3-end processing (GO:0043628)2.96170852
75L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.86484022
76mRNA catabolic process (GO:0006402)2.85910257
77detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.81005434
78ribonucleoside triphosphate biosynthetic process (GO:0009201)2.80449516
79protein targeting to mitochondrion (GO:0006626)2.79972560
80rRNA processing (GO:0006364)2.78239329
81protein-cofactor linkage (GO:0018065)2.73295784
82ketone body metabolic process (GO:1902224)2.71283016
83establishment of protein localization to mitochondrion (GO:0072655)2.71146656
84tRNA processing (GO:0008033)2.67733269
85negative regulation of appetite (GO:0032099)2.66739732
86negative regulation of response to food (GO:0032096)2.66739732
87formation of translation preinitiation complex (GO:0001731)2.66417683
88rRNA metabolic process (GO:0016072)2.66091000
89replication fork processing (GO:0031297)2.65440851
90cytochrome complex assembly (GO:0017004)2.65417160
91UTP biosynthetic process (GO:0006228)2.64909074
92rRNA modification (GO:0000154)2.64291590
93pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.62848174
94pseudouridine synthesis (GO:0001522)2.59856315
95tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.58909688
96RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.58909688
97regulation of telomerase activity (GO:0051972)2.57734611
98metallo-sulfur cluster assembly (GO:0031163)2.57456571
99iron-sulfur cluster assembly (GO:0016226)2.57456571
100regulation of cellular respiration (GO:0043457)2.56405331

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.26782227
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.19820910
3VDR_22108803_ChIP-Seq_LS180_Human3.54200139
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.50431046
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.23681933
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.11826462
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.88274820
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.81534245
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.61056918
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.59434916
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.58726487
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.49079715
13VDR_23849224_ChIP-Seq_CD4+_Human2.33190585
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.23543319
15MYC_18940864_ChIP-ChIP_HL60_Human2.21380421
16ZNF274_21170338_ChIP-Seq_K562_Hela2.20006240
17ELK1_19687146_ChIP-ChIP_HELA_Human2.10022644
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.05582775
19FUS_26573619_Chip-Seq_HEK293_Human2.05077657
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.97698230
21MYC_18555785_ChIP-Seq_MESCs_Mouse1.93619494
22EZH2_22144423_ChIP-Seq_EOC_Human1.93329897
23EWS_26573619_Chip-Seq_HEK293_Human1.86578896
24TAF15_26573619_Chip-Seq_HEK293_Human1.83567304
25FOXP3_21729870_ChIP-Seq_TREG_Human1.83354675
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81327417
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.73118554
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.69512699
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63659997
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.58553932
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55842377
32TTF2_22483619_ChIP-Seq_HELA_Human1.54811965
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49781527
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.49214259
35GABP_19822575_ChIP-Seq_HepG2_Human1.48600453
36TP53_22573176_ChIP-Seq_HFKS_Human1.46292795
37TDRD3_21172665_ChIP-Seq_MCF-7_Human1.40190103
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39826842
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.38821729
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32191551
41GATA3_21878914_ChIP-Seq_MCF-7_Human1.30699245
42CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30683647
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30173902
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29041619
45EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25578952
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.24917519
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.22916155
48AR_20517297_ChIP-Seq_VCAP_Human1.21886425
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21644393
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.21285707
51ELK1_22589737_ChIP-Seq_MCF10A_Human1.20623067
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19865690
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16981646
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15276852
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14655008
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14180966
57P300_19829295_ChIP-Seq_ESCs_Human1.13712141
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.13687454
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13687454
60EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.13396317
61AR_21572438_ChIP-Seq_LNCaP_Human1.09272455
62FOXH1_21741376_ChIP-Seq_EPCs_Human1.09088062
63NANOG_20526341_ChIP-Seq_ESCs_Human1.08895632
64SOX2_19829295_ChIP-Seq_ESCs_Human1.08146984
65NANOG_19829295_ChIP-Seq_ESCs_Human1.08146984
66ERG_20517297_ChIP-Seq_VCAP_Human1.07884103
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.07161935
68XRN2_22483619_ChIP-Seq_HELA_Human1.04382486
69FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04373088
70GATA3_26560356_Chip-Seq_TH2_Human1.03478220
71IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03357132
72STAT3_18555785_Chip-Seq_ESCs_Mouse1.02823114
73CIITA_25753668_ChIP-Seq_RAJI_Human1.02031486
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02017468
75MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01625272
76PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.99505890
77GBX2_23144817_ChIP-Seq_PC3_Human0.99122167
78ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97536165
79CRX_20693478_ChIP-Seq_RETINA_Mouse0.97127713
80TAF2_19829295_ChIP-Seq_ESCs_Human0.96828422
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96702273
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96312212
83IRF1_19129219_ChIP-ChIP_H3396_Human0.95811291
84P53_21459846_ChIP-Seq_SAOS-2_Human0.95707084
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94610370
86DCP1A_22483619_ChIP-Seq_HELA_Human0.94179312
87P53_22387025_ChIP-Seq_ESCs_Mouse0.93694546
88EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93559291
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90111203
90TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89805216
91MYC_19829295_ChIP-Seq_ESCs_Human0.89030377
92NCOR_22424771_ChIP-Seq_293T_Human0.88662879
93SOX2_18555785_Chip-Seq_ESCs_Mouse0.88006780
94FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86928834
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86532834
96CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86252269
97FOXH1_21741376_ChIP-Seq_ESCs_Human0.86011118
98BCAT_22108803_ChIP-Seq_LS180_Human0.85632699
99PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84515435
100HOXB7_26014856_ChIP-Seq_BT474_Human0.83251547

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.22178490
2MP0000569_abnormal_digit_pigmentation4.47397826
3MP0000566_synostosis2.94191342
4MP0005174_abnormal_tail_pigmentation2.86578959
5MP0006292_abnormal_olfactory_placode2.77630250
6MP0005671_abnormal_response_to2.51424191
7MP0005645_abnormal_hypothalamus_physiol2.49382921
8MP0002736_abnormal_nociception_after2.23671512
9MP0002095_abnormal_skin_pigmentation2.18576067
10MP0005646_abnormal_pituitary_gland2.16193010
11MP0002876_abnormal_thyroid_physiology2.11210614
12MP0002277_abnormal_respiratory_mucosa2.05597390
13MP0004142_abnormal_muscle_tone2.03980446
14MP0003186_abnormal_redox_activity1.97594133
15MP0004885_abnormal_endolymph1.96726632
16MP0004147_increased_porphyrin_level1.96076121
17MP0001968_abnormal_touch/_nociception1.94119248
18MP0002163_abnormal_gland_morphology1.87517248
19MP0002938_white_spotting1.77463439
20MP0001905_abnormal_dopamine_level1.77355138
21MP0002837_dystrophic_cardiac_calcinosis1.77069158
22MP0003724_increased_susceptibility_to1.76903319
23MP0001485_abnormal_pinna_reflex1.73132332
24MP0001835_abnormal_antigen_presentation1.69631131
25MP0003806_abnormal_nucleotide_metabolis1.69457335
26MP0005379_endocrine/exocrine_gland_phen1.65010729
27MP0000015_abnormal_ear_pigmentation1.63814537
28MP0008877_abnormal_DNA_methylation1.57590190
29MP0000372_irregular_coat_pigmentation1.50773687
30MP0002234_abnormal_pharynx_morphology1.46890437
31MP0005332_abnormal_amino_acid1.42060220
32MP0002138_abnormal_hepatobiliary_system1.41940434
33MP0002148_abnormal_hypersensitivity_rea1.40377805
34MP0001529_abnormal_vocalization1.39347182
35MP0001873_stomach_inflammation1.36030194
36MP0005636_abnormal_mineral_homeostasis1.33201526
37MP0005075_abnormal_melanosome_morpholog1.32306730
38MP0005377_hearing/vestibular/ear_phenot1.32134678
39MP0003878_abnormal_ear_physiology1.32134678
40MP0008875_abnormal_xenobiotic_pharmacok1.31051734
41MP0008872_abnormal_physiological_respon1.30598729
42MP0005551_abnormal_eye_electrophysiolog1.29080564
43MP0003718_maternal_effect1.27888079
44MP0005084_abnormal_gallbladder_morpholo1.26724989
45MP0001986_abnormal_taste_sensitivity1.23929826
46MP0003045_fibrosis1.22686750
47MP0004145_abnormal_muscle_electrophysio1.22379286
48MP0006036_abnormal_mitochondrial_physio1.18838627
49MP0009745_abnormal_behavioral_response1.18489150
50MP0000685_abnormal_immune_system1.18126773
51MP0002272_abnormal_nervous_system1.16642192
52MP0005367_renal/urinary_system_phenotyp1.15957339
53MP0000516_abnormal_urinary_system1.15957339
54MP0008789_abnormal_olfactory_epithelium1.11735522
55MP0003646_muscle_fatigue1.08990438
56MP0005165_increased_susceptibility_to1.08694160
57MP0001765_abnormal_ion_homeostasis1.05840273
58MP0001853_heart_inflammation1.03958863
59MP0002928_abnormal_bile_duct1.03147410
60MP0008775_abnormal_heart_ventricle1.00948531
61MP0003137_abnormal_impulse_conducting1.00324370
62MP0001293_anophthalmia0.96369037
63MP0001756_abnormal_urination0.95821418
64MP0003011_delayed_dark_adaptation0.94706608
65MP0004215_abnormal_myocardial_fiber0.92155230
66MP0001879_abnormal_lymphatic_vessel0.90645564
67MP0000639_abnormal_adrenal_gland0.90519250
68MP0005408_hypopigmentation0.90026147
69MP0009785_altered_susceptibility_to0.90016283
70MP0006276_abnormal_autonomic_nervous0.89789917
71MP0005171_absent_coat_pigmentation0.89736625
72MP0004742_abnormal_vestibular_system0.87927708
73MP0004484_altered_response_of0.87845303
74MP0002693_abnormal_pancreas_physiology0.87264812
75MP0002638_abnormal_pupillary_reflex0.84562316
76MP0003638_abnormal_response/metabolism_0.82835313
77MP0009046_muscle_twitch0.81105024
78MP0002160_abnormal_reproductive_system0.78651742
79MP0001970_abnormal_pain_threshold0.77756811
80MP0002733_abnormal_thermal_nociception0.77566468
81MP0005387_immune_system_phenotype0.76811569
82MP0001790_abnormal_immune_system0.76811569
83MP0000026_abnormal_inner_ear0.75708235
84MP0001800_abnormal_humoral_immune0.73752193
85MP0002822_catalepsy0.73041214
86MP0005389_reproductive_system_phenotype0.73015732
87MP0001663_abnormal_digestive_system0.71542548
88MP0003122_maternal_imprinting0.71165425
89MP0006035_abnormal_mitochondrial_morpho0.70430536
90MP0005448_abnormal_energy_balance0.69529034
91MP0001727_abnormal_embryo_implantation0.68643382
92MP0005360_urolithiasis0.68473147
93MP0000049_abnormal_middle_ear0.68452556
94MP0010386_abnormal_urinary_bladder0.68213633
95MP0001764_abnormal_homeostasis0.66787768
96MP0000631_abnormal_neuroendocrine_gland0.66657974
97MP0002127_abnormal_cardiovascular_syste0.66266392
98MP0001963_abnormal_hearing_physiology0.65673721
99MP0000013_abnormal_adipose_tissue0.65499096
100MP0005253_abnormal_eye_physiology0.65339665

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.83426901
2Abnormality of cells of the erythroid lineage (HP:0012130)4.38682218
3Acute necrotizing encephalopathy (HP:0006965)4.33165556
4Thyroid-stimulating hormone excess (HP:0002925)4.23448593
5Macrocytic anemia (HP:0001972)3.95345326
6Mitochondrial inheritance (HP:0001427)3.84609912
7Progressive macrocephaly (HP:0004481)3.70966650
8Acute encephalopathy (HP:0006846)3.69456855
9Hyperglycinemia (HP:0002154)3.68436957
10Abnormal mitochondria in muscle tissue (HP:0008316)3.65277108
11Abnormal number of erythroid precursors (HP:0012131)3.62241902
12Increased CSF lactate (HP:0002490)3.58967335
13Hypoplasia of the uterus (HP:0000013)3.53287971
14Hepatocellular necrosis (HP:0001404)3.40156168
15Hepatic necrosis (HP:0002605)3.27711359
16Abnormality of midbrain morphology (HP:0002418)3.22102690
17Molar tooth sign on MRI (HP:0002419)3.22102690
18Hyperalaninemia (HP:0003348)3.16347692
19Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.16347692
20Abnormality of alanine metabolism (HP:0010916)3.16347692
21Renal cortical cysts (HP:0000803)3.13715506
22Stenosis of the external auditory canal (HP:0000402)3.13209264
23Congenital stationary night blindness (HP:0007642)3.05565965
243-Methylglutaconic aciduria (HP:0003535)2.99409617
25Methylmalonic acidemia (HP:0002912)2.91995944
26Lipid accumulation in hepatocytes (HP:0006561)2.83785765
27Aplasia/Hypoplasia of the sacrum (HP:0008517)2.83095272
28Aplasia/hypoplasia of the uterus (HP:0008684)2.79803478
29Nephronophthisis (HP:0000090)2.68968176
30Optic disc pallor (HP:0000543)2.60690370
31Cerebral edema (HP:0002181)2.58402637
32Lethargy (HP:0001254)2.54929195
33Pancreatic cysts (HP:0001737)2.53081547
34Hyperglycinuria (HP:0003108)2.52242359
35Increased hepatocellular lipid droplets (HP:0006565)2.51321749
36Microretrognathia (HP:0000308)2.51167180
37Absent thumb (HP:0009777)2.46776550
38Pallor (HP:0000980)2.41940631
39Aplasia/Hypoplasia of the spleen (HP:0010451)2.40878766
40Asplenia (HP:0001746)2.39867143
41Hip dysplasia (HP:0001385)2.35269400
42Increased serum lactate (HP:0002151)2.34427051
43Lactic acidosis (HP:0003128)2.34098202
44Medial flaring of the eyebrow (HP:0010747)2.33397617
45Type 2 muscle fiber atrophy (HP:0003554)2.32986618
46Abnormality of the renal cortex (HP:0011035)2.30886547
47Partial duplication of thumb phalanx (HP:0009944)2.28492660
48Renal Fanconi syndrome (HP:0001994)2.28130221
49Pancreatic fibrosis (HP:0100732)2.27408025
50Abnormality of the renal medulla (HP:0100957)2.24507772
51Abnormality of glycine metabolism (HP:0010895)2.20509602
52Abnormality of serine family amino acid metabolism (HP:0010894)2.20509602
53Stomatitis (HP:0010280)2.20239416
54Stomach cancer (HP:0012126)2.18672363
55Type II lissencephaly (HP:0007260)2.17493492
56Hemiparesis (HP:0001269)2.14837928
57Methylmalonic aciduria (HP:0012120)2.13675198
58Abnormal hemoglobin (HP:0011902)2.13587166
59Agitation (HP:0000713)2.13488992
60Leukodystrophy (HP:0002415)2.12429749
61Abnormality of DNA repair (HP:0003254)2.11158897
62Abnormal rod and cone electroretinograms (HP:0008323)2.09374569
63Abnormality of serum amino acid levels (HP:0003112)2.05426672
64Increased serum pyruvate (HP:0003542)2.03463220
65Restlessness (HP:0000711)1.97911417
66Adrenal hypoplasia (HP:0000835)1.96334987
67Exertional dyspnea (HP:0002875)1.96195843
68Parakeratosis (HP:0001036)1.95963041
69Elevated erythrocyte sedimentation rate (HP:0003565)1.93544722
70Respiratory failure (HP:0002878)1.92220904
71Muscle fiber atrophy (HP:0100295)1.91753835
72Bifid tongue (HP:0010297)1.91744983
73Porencephaly (HP:0002132)1.91257432
74Abnormality of the prostate (HP:0008775)1.90852684
75Type I transferrin isoform profile (HP:0003642)1.90762285
76Progressive microcephaly (HP:0000253)1.88854897
77Focal motor seizures (HP:0011153)1.87922582
78Albinism (HP:0001022)1.87278519
79Partial duplication of the phalanx of hand (HP:0009999)1.87223510
80Abnormality of vitamin B metabolism (HP:0004340)1.81594799
81Impulsivity (HP:0100710)1.81492374
82Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81376251
83Median cleft lip (HP:0000161)1.79983377
84Nephrogenic diabetes insipidus (HP:0009806)1.79492966
85Testicular atrophy (HP:0000029)1.79042958
86True hermaphroditism (HP:0010459)1.78916282
87Bulbous nose (HP:0000414)1.78676192
88Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77720046
89Type I diabetes mellitus (HP:0100651)1.76370328
90IgG deficiency (HP:0004315)1.71986420
91Congenital primary aphakia (HP:0007707)1.70135627
92Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.67470496
93Decreased activity of mitochondrial respiratory chain (HP:0008972)1.67470496
94Hypoplasia of the ulna (HP:0003022)1.67287388
95Humeroradial synostosis (HP:0003041)1.66045705
96Synostosis involving the elbow (HP:0003938)1.66045705
97Pendular nystagmus (HP:0012043)1.65170683
98Abnormality of the vitamin B12 metabolism (HP:0004341)1.64888101
99Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.63114954
100Gait imbalance (HP:0002141)1.63060811

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K27.04059334
2ZAK3.60303787
3MAP3K123.16204951
4MST43.05970359
5TXK2.86682664
6WNK42.59348546
7BUB12.39150236
8NME22.24675350
9ADRBK22.22052757
10VRK22.16629525
11FRK1.98321215
12TLK11.98100890
13CDK191.95165772
14OXSR11.77921682
15TESK21.73505918
16MAP3K131.73004426
17TAOK31.53613515
18GRK11.51925970
19PDK21.48664508
20IKBKB1.28033536
21MAPKAPK51.24736183
22BMPR21.22437259
23STK391.15746512
24DYRK21.15217308
25ARAF1.11678701
26PASK1.11610512
27MKNK11.06053294
28TAF11.05439682
29MAP3K91.03572612
30STK241.03418501
31PAK31.02999308
32MAP3K140.89657519
33MYLK0.85797427
34PRKCI0.85775949
35KIT0.83409187
36MAP2K60.80149636
37VRK10.79139374
38MATK0.78417354
39RPS6KA50.76750097
40MAP4K10.73118376
41STK38L0.72164516
42CSNK1G30.71897154
43LIMK10.70811582
44PRKCQ0.69703603
45TIE10.69183188
46DYRK30.69135130
47MAPKAPK30.68090259
48GRK60.64901061
49MAP3K110.64419948
50CSNK1G20.62946136
51TRIM280.62737058
52EPHA30.61590589
53CHEK20.60177430
54BRAF0.57192362
55ADRBK10.56855246
56CSNK1G10.55627740
57CAMK10.54918083
58FGFR20.54718687
59MAP3K40.53275582
60DAPK20.51566888
61MAP2K20.50147410
62BCKDK0.49510225
63IKBKE0.49160842
64KDR0.48875463
65ILK0.48808136
66KSR10.48430736
67JAK10.48393947
68DAPK10.47769046
69CSNK1A1L0.47100161
70INSRR0.46892752
71DAPK30.46536696
72ABL20.46237577
73CCNB10.46215272
74MAP2K70.45956602
75EIF2AK20.45678178
76NUAK10.45663229
77PRKCE0.44599402
78PINK10.44423325
79NEK10.42249855
80CASK0.41464563
81MAPK130.40749060
82CSNK2A20.38999794
83AURKB0.38078169
84TNK20.37878574
85PAK60.37719999
86CDK80.37541012
87RIPK40.37310248
88ATR0.36809228
89TTK0.36669649
90PRKCH0.34626653
91WNK30.34346218
92PIK3CG0.33567564
93PRKACA0.33346944
94CHUK0.33119314
95TSSK60.32474168
96CSNK1E0.32452795
97STK160.32071688
98MARK30.31437042
99PLK10.31337121
100GRK50.30836877

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.14251051
2Oxidative phosphorylation_Homo sapiens_hsa001904.37908006
3Parkinsons disease_Homo sapiens_hsa050123.64993169
4Protein export_Homo sapiens_hsa030603.00361523
5Proteasome_Homo sapiens_hsa030502.66461792
6Alzheimers disease_Homo sapiens_hsa050102.45396006
7One carbon pool by folate_Homo sapiens_hsa006702.39816523
8Huntingtons disease_Homo sapiens_hsa050162.33699386
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.19039123
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.15539250
11Asthma_Homo sapiens_hsa053102.14508270
12Sulfur metabolism_Homo sapiens_hsa009202.04072688
13Phototransduction_Homo sapiens_hsa047441.93033904
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91917618
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.90838176
16Cardiac muscle contraction_Homo sapiens_hsa042601.85212208
17Basal transcription factors_Homo sapiens_hsa030221.81952516
18RNA degradation_Homo sapiens_hsa030181.80427600
19RNA polymerase_Homo sapiens_hsa030201.61217755
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58646961
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52789529
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51401616
23Type I diabetes mellitus_Homo sapiens_hsa049401.44377876
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.39369513
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.32735666
26Allograft rejection_Homo sapiens_hsa053301.27468216
27Propanoate metabolism_Homo sapiens_hsa006401.27392174
28Autoimmune thyroid disease_Homo sapiens_hsa053201.24882546
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24657085
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21114168
31Linoleic acid metabolism_Homo sapiens_hsa005911.20122468
32Graft-versus-host disease_Homo sapiens_hsa053321.16188180
33Antigen processing and presentation_Homo sapiens_hsa046121.15659451
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.12904319
35Folate biosynthesis_Homo sapiens_hsa007901.07598972
36Butanoate metabolism_Homo sapiens_hsa006501.01396925
37Spliceosome_Homo sapiens_hsa030401.00772828
38Nucleotide excision repair_Homo sapiens_hsa034200.98639361
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98440048
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96156988
41Regulation of autophagy_Homo sapiens_hsa041400.94764584
42Nitrogen metabolism_Homo sapiens_hsa009100.90266868
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89205569
44Purine metabolism_Homo sapiens_hsa002300.88946045
45Primary immunodeficiency_Homo sapiens_hsa053400.86984792
46Tryptophan metabolism_Homo sapiens_hsa003800.86099933
47Nicotine addiction_Homo sapiens_hsa050330.85424924
48Glutathione metabolism_Homo sapiens_hsa004800.83480624
49Fatty acid elongation_Homo sapiens_hsa000620.82029552
50RNA transport_Homo sapiens_hsa030130.80352041
51Morphine addiction_Homo sapiens_hsa050320.78066537
52Collecting duct acid secretion_Homo sapiens_hsa049660.75775521
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75093841
54Rheumatoid arthritis_Homo sapiens_hsa053230.75050438
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74649160
56Pyrimidine metabolism_Homo sapiens_hsa002400.72009725
57Steroid biosynthesis_Homo sapiens_hsa001000.71796581
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69910511
59Caffeine metabolism_Homo sapiens_hsa002320.69732211
60Peroxisome_Homo sapiens_hsa041460.69693034
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.68664465
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67724320
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.67536530
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65021247
65Metabolic pathways_Homo sapiens_hsa011000.63604701
66Arachidonic acid metabolism_Homo sapiens_hsa005900.62633607
67Fanconi anemia pathway_Homo sapiens_hsa034600.61212542
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60744177
69Homologous recombination_Homo sapiens_hsa034400.59488066
70Base excision repair_Homo sapiens_hsa034100.58521323
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58125877
72Olfactory transduction_Homo sapiens_hsa047400.56960346
73Arginine and proline metabolism_Homo sapiens_hsa003300.56431894
74Chemical carcinogenesis_Homo sapiens_hsa052040.56090484
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53680677
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51301976
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49054808
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46980760
79Retinol metabolism_Homo sapiens_hsa008300.46890122
80GABAergic synapse_Homo sapiens_hsa047270.46447630
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.45561560
82beta-Alanine metabolism_Homo sapiens_hsa004100.45080139
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42522027
84Vitamin B6 metabolism_Homo sapiens_hsa007500.41517303
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.36664433
86Insulin secretion_Homo sapiens_hsa049110.36204792
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36171250
88Serotonergic synapse_Homo sapiens_hsa047260.35364644
89Fatty acid degradation_Homo sapiens_hsa000710.33840055
90Glycerolipid metabolism_Homo sapiens_hsa005610.33338716
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31354357
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31069390
93Mismatch repair_Homo sapiens_hsa034300.30260501
94Pyruvate metabolism_Homo sapiens_hsa006200.25717491
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.22803528
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.22601414
97Epstein-Barr virus infection_Homo sapiens_hsa051690.18841742
98Salivary secretion_Homo sapiens_hsa049700.18422139
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.16002774
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.15883002

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