ATP5H

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the d subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. In addition, three pseudogenes are located on chromosomes 9, 12 and 15. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* ATP synthesis coupled proton transport (GO:0015986)9.94288217
2* energy coupled proton transport, down electrochemical gradient (GO:0015985)9.94288217
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)9.30103630
4* respiratory electron transport chain (GO:0022904)8.54920825
5* electron transport chain (GO:0022900)8.33151001
6ribosomal small subunit assembly (GO:0000028)6.25601313
7nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.45423030
8maturation of SSU-rRNA (GO:0030490)5.42648274
9* ATP biosynthetic process (GO:0006754)5.39361349
10translational initiation (GO:0006413)5.36928479
11ribosomal large subunit biogenesis (GO:0042273)5.36727650
12oxidative phosphorylation (GO:0006119)5.23047119
13* hydrogen ion transmembrane transport (GO:1902600)5.09410749
14chaperone-mediated protein transport (GO:0072321)5.07677590
15* purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.92115830
16* purine nucleoside triphosphate biosynthetic process (GO:0009145)4.83697797
17inner mitochondrial membrane organization (GO:0007007)4.82622549
18mitochondrial respiratory chain complex I assembly (GO:0032981)4.78297150
19NADH dehydrogenase complex assembly (GO:0010257)4.78297150
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.78297150
21protein complex disassembly (GO:0043241)4.77938808
22protein complex biogenesis (GO:0070271)4.77774765
23establishment of protein localization to mitochondrial membrane (GO:0090151)4.76418271
24translation (GO:0006412)4.69731166
25macromolecular complex disassembly (GO:0032984)4.56396901
26protein targeting to membrane (GO:0006612)4.50154475
27* proton transport (GO:0015992)4.46960644
28* hydrogen transport (GO:0006818)4.39369915
29mitochondrial respiratory chain complex assembly (GO:0033108)4.35609612
30* ribonucleoside triphosphate biosynthetic process (GO:0009201)4.26311598
31proteasome assembly (GO:0043248)4.23062571
32protein neddylation (GO:0045116)4.20445322
33tricarboxylic acid cycle (GO:0006099)4.16892994
34sequestering of actin monomers (GO:0042989)3.85060225
35nuclear-transcribed mRNA catabolic process (GO:0000956)3.84353728
36regulation of oxidative phosphorylation (GO:0002082)3.76583891
37aerobic respiration (GO:0009060)3.72321214
38cellular component biogenesis (GO:0044085)3.66324333
39mRNA catabolic process (GO:0006402)3.62951220
40* nucleoside triphosphate biosynthetic process (GO:0009142)3.61909715
41ribosomal small subunit biogenesis (GO:0042274)3.61751687
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.58215265
43termination of RNA polymerase III transcription (GO:0006386)3.57521633
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.57521633
45ribonucleoprotein complex biogenesis (GO:0022613)3.57162041
46viral transcription (GO:0019083)3.53950796
47energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.52785176
48ATP hydrolysis coupled proton transport (GO:0015991)3.52785176
49positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.49345098
50NADH metabolic process (GO:0006734)3.48858187
51regulation of acyl-CoA biosynthetic process (GO:0050812)3.47300812
52translational termination (GO:0006415)3.39796089
53regulation of mitochondrial translation (GO:0070129)3.32403422
54GTP biosynthetic process (GO:0006183)3.31481068
55negative regulation of ligase activity (GO:0051352)3.29947221
56negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.29947221
57negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.28200758
58central nervous system myelination (GO:0022010)3.27756983
59axon ensheathment in central nervous system (GO:0032291)3.27756983
60positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.26659785
61substantia nigra development (GO:0021762)3.26056207
62RNA catabolic process (GO:0006401)3.25246737
63establishment of protein localization to membrane (GO:0090150)3.25122285
64succinate metabolic process (GO:0006105)3.24833466
65* mitochondrial transport (GO:0006839)3.22588363
66regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.22304027
67dopamine transport (GO:0015872)3.21936825
68* generation of precursor metabolites and energy (GO:0006091)3.21162564
69regulation of cofactor metabolic process (GO:0051193)3.21051979
70regulation of coenzyme metabolic process (GO:0051196)3.21051979
71regulation of cellular respiration (GO:0043457)3.18083413
72anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.17493581
73cotranslational protein targeting to membrane (GO:0006613)3.15189046
74protein targeting (GO:0006605)3.13393656
75regulation of cellular amino acid metabolic process (GO:0006521)3.09288727
76protein targeting to ER (GO:0045047)3.08134687
77establishment of integrated proviral latency (GO:0075713)3.07646276
78regulation of cell communication by electrical coupling (GO:0010649)3.06191924
79SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.04074398
80calcium-mediated signaling using intracellular calcium source (GO:0035584)3.03017108
81regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.02837826
82negative regulation of protein localization to cell surface (GO:2000009)3.01840241
83establishment of protein localization to endoplasmic reticulum (GO:0072599)3.00449919
84* purine nucleoside monophosphate biosynthetic process (GO:0009127)2.99369270
85* purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.99369270
86quinone biosynthetic process (GO:1901663)2.97625365
87ubiquinone biosynthetic process (GO:0006744)2.97625365
88cellular respiration (GO:0045333)2.97534730
89protein localization to endoplasmic reticulum (GO:0070972)2.97527992
90sarcomere organization (GO:0045214)2.96317223
91regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.94237811
92fatty acid elongation (GO:0030497)2.93426470
93regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.92518081
94regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.92181234
95establishment of protein localization to organelle (GO:0072594)2.91908123
96DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.89365994
97rRNA processing (GO:0006364)2.88943716
98negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.88894005
99tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.87071775
100RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.87071775
101respiratory chain complex IV assembly (GO:0008535)2.86243873
102signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.85412239
103signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.85412239
104signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.85412239
105response to epinephrine (GO:0071871)2.85314501
106spliceosomal snRNP assembly (GO:0000387)2.84958209
107establishment of protein localization to mitochondrion (GO:0072655)2.84481602
108cellular ketone body metabolic process (GO:0046950)2.84086824
109intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.83710124
110signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.83710124
111protein targeting to mitochondrion (GO:0006626)2.83414456
112positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.83107452
113signal transduction involved in DNA damage checkpoint (GO:0072422)2.79938372
114signal transduction involved in DNA integrity checkpoint (GO:0072401)2.79938372
115ubiquinone metabolic process (GO:0006743)2.78387345
116regulation of catecholamine metabolic process (GO:0042069)2.77014591
117regulation of dopamine metabolic process (GO:0042053)2.77014591
118cellular protein complex disassembly (GO:0043624)2.75278518
119cellular response to epinephrine stimulus (GO:0071872)2.75192264
120detection of calcium ion (GO:0005513)2.74877424
121rRNA modification (GO:0000154)2.74867953
122protein localization to mitochondrion (GO:0070585)2.74521510
123rRNA metabolic process (GO:0016072)2.73873723
124signal transduction involved in cell cycle checkpoint (GO:0072395)2.73872360
125DNA damage response, detection of DNA damage (GO:0042769)2.73577613
126* purine ribonucleoside biosynthetic process (GO:0046129)2.73080250
127* purine nucleoside biosynthetic process (GO:0042451)2.73080250
128chromatin remodeling at centromere (GO:0031055)2.72735731
129CENP-A containing nucleosome assembly (GO:0034080)2.72330517
130translational elongation (GO:0006414)2.72233558
131formation of translation preinitiation complex (GO:0001731)2.70775909
132neuron cell-cell adhesion (GO:0007158)2.69990864
1337-methylguanosine mRNA capping (GO:0006370)2.69604955
134positive regulation of ligase activity (GO:0051351)2.69303904
135viral life cycle (GO:0019058)2.65490180
136regulation of actin filament-based movement (GO:1903115)2.64070537
137regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.63681228
138UTP biosynthetic process (GO:0006228)2.62333105
139muscle filament sliding (GO:0030049)2.61749762
140actin-myosin filament sliding (GO:0033275)2.61749762
141cytochrome complex assembly (GO:0017004)2.60977414
142regulation of relaxation of muscle (GO:1901077)2.59628613
143sarcoplasmic reticulum calcium ion transport (GO:0070296)2.59243402
144intracellular protein transmembrane import (GO:0044743)2.58268811
145heart process (GO:0003015)2.54810073
146heart contraction (GO:0060047)2.54810073
147ketone body metabolic process (GO:1902224)2.51022101
148long-chain fatty acid biosynthetic process (GO:0042759)2.50344034
149negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.49420997
150negative regulation of calcium ion transmembrane transport (GO:1903170)2.49420997
151* mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.5165836

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.39797017
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.04486544
3EZH2_22144423_ChIP-Seq_EOC_Human3.95113548
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.33774318
5ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.12225682
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.98819719
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.74366514
8VDR_22108803_ChIP-Seq_LS180_Human2.74181304
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.66277186
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.62864581
11TAF15_26573619_Chip-Seq_HEK293_Human2.62294120
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.60968932
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.47063129
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.41798420
15GBX2_23144817_ChIP-Seq_PC3_Human2.41715517
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.39726325
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.33382690
18XRN2_22483619_ChIP-Seq_HELA_Human2.31187815
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.20957166
20TTF2_22483619_ChIP-Seq_HELA_Human2.19072507
21E2F7_22180533_ChIP-Seq_HELA_Human2.16212849
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13580993
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.12030762
24VDR_23849224_ChIP-Seq_CD4+_Human2.11461194
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.09494639
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.08557041
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03821009
28JARID2_20064375_ChIP-Seq_MESCs_Mouse2.03613091
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.03607944
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01243167
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.98750561
32* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91103361
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.89555364
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87811692
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.87512387
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.87444041
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.86732464
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.83663898
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80870475
40POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.80535949
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78499435
42FOXP3_21729870_ChIP-Seq_TREG_Human1.76114516
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74744567
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71251024
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70651842
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.69374189
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.66892840
48MYC_18940864_ChIP-ChIP_HL60_Human1.66793319
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.63474714
50FUS_26573619_Chip-Seq_HEK293_Human1.62113865
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59037733
52EZH2_18974828_ChIP-Seq_MESCs_Mouse1.51514333
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.51514333
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51345055
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50522841
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.49149792
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49087314
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.47407314
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.47384322
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43049546
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42683403
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41122969
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40388482
64* GABP_19822575_ChIP-Seq_HepG2_Human1.37976295
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37044243
66* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36207308
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35852979
68SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.35687654
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35376147
70SOX2_16153702_ChIP-ChIP_HESCs_Human1.34102549
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33513944
72P300_19829295_ChIP-Seq_ESCs_Human1.33500943
73SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32678523
74ER_23166858_ChIP-Seq_MCF-7_Human1.32665724
75EZH2_27294783_Chip-Seq_ESCs_Mouse1.30980629
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29930275
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.27782129
78EP300_21415370_ChIP-Seq_HL-1_Mouse1.26705337
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26355247
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25148700
81* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.24497724
82REST_21632747_ChIP-Seq_MESCs_Mouse1.24421804
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23253531
84AR_21909140_ChIP-Seq_LNCAP_Human1.22549757
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22520770
86CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.22294154
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20348922
88FOXM1_23109430_ChIP-Seq_U2OS_Human1.19749101
89NANOG_16153702_ChIP-ChIP_HESCs_Human1.19525694
90ZNF274_21170338_ChIP-Seq_K562_Hela1.18750412
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18490627
92HTT_18923047_ChIP-ChIP_STHdh_Human1.17883728
93IRF1_19129219_ChIP-ChIP_H3396_Human1.16212026
94REST_18959480_ChIP-ChIP_MESCs_Mouse1.14604242
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14548016
96YY1_21170310_ChIP-Seq_MESCs_Mouse1.14092982
97NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13812467
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13340639
99PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12834201
100THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12043561
101ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10539258
102CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09430053
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09427957
104E2F1_21310950_ChIP-Seq_MCF-7_Human1.09295674
105MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04752290
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04185687
107RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04152002
108SMAD3_21741376_ChIP-Seq_EPCs_Human1.03834728
109EWS_26573619_Chip-Seq_HEK293_Human1.03571698
110SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01821135
111SOX17_20123909_ChIP-Seq_XEN_Mouse0.98633065
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97722401
113BP1_19119308_ChIP-ChIP_Hs578T_Human0.97268594
114NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96835694
115PIAS1_25552417_ChIP-Seq_VCAP_Human0.96607854
116CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96580369
117CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.96425118
118ZNF263_19887448_ChIP-Seq_K562_Human0.96326688
119* ELK1_22589737_ChIP-Seq_MCF10A_Human0.96232179
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94578437
121DCP1A_22483619_ChIP-Seq_HELA_Human0.94277909
122MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92566566
123ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89463600
124EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.88594050
125* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87644395
126BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87611548
127NANOG_19829295_ChIP-Seq_ESCs_Human0.86540020
128SOX2_19829295_ChIP-Seq_ESCs_Human0.86540020
129PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86505070
130ETV2_25802403_ChIP-Seq_MESCs_Mouse0.85523625
131SMAD4_21799915_ChIP-Seq_A2780_Human0.84652566
132RNF2_27304074_Chip-Seq_ESCs_Mouse0.84358833
133POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83655754
134BCAT_22108803_ChIP-Seq_LS180_Human0.83158051
135JUN_21703547_ChIP-Seq_K562_Human0.83084151
136ELK1_19687146_ChIP-ChIP_HELA_Human0.81754824
137CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81137800
138ERG_21242973_ChIP-ChIP_JURKAT_Human0.80331460
139EGR1_23403033_ChIP-Seq_LIVER_Mouse0.80044825
140PCGF2_27294783_Chip-Seq_ESCs_Mouse0.80032458
141CTCF_18555785_ChIP-Seq_MESCs_Mouse0.79758319
142TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.79595725
143AR_21572438_ChIP-Seq_LNCaP_Human0.79314140
144REST_19997604_ChIP-ChIP_NEURONS_Mouse0.78854491
145PRDM14_20953172_ChIP-Seq_ESCs_Human0.78781104
146OCT4_18692474_ChIP-Seq_MEFs_Mouse0.78759036
147GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78450903
148NCOR_22424771_ChIP-Seq_293T_Human0.78058041
149SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.77690016
150CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.77577649
151SRY_22984422_ChIP-ChIP_TESTIS_Rat0.77238644
152ERG_20517297_ChIP-Seq_VCAP_Human0.77042510
153ERG_20887958_ChIP-Seq_HPC-7_Mouse0.74882627
154SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.73823516
155SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73773779
156KDM5A_27292631_Chip-Seq_BREAST_Human0.73742039
157NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.72397517
158ESR1_15608294_ChIP-ChIP_MCF-7_Human0.71359390
159ELF5_23300383_ChIP-Seq_T47D_Human0.70051831
160TP53_22573176_ChIP-Seq_HFKS_Human0.69486538
161TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.68899747

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.26533242
2MP0003880_abnormal_central_pattern4.20712690
3MP0001529_abnormal_vocalization3.55255617
4MP0004215_abnormal_myocardial_fiber3.08661987
5MP0003646_muscle_fatigue2.93728787
6MP0000751_myopathy2.90410943
7MP0000372_irregular_coat_pigmentation2.66264480
8MP0004084_abnormal_cardiac_muscle2.59797341
9MP0009379_abnormal_foot_pigmentation2.58714422
10MP0004036_abnormal_muscle_relaxation2.54934923
11MP0003941_abnormal_skin_development2.52927249
12MP0006036_abnormal_mitochondrial_physio2.51747755
13MP0001905_abnormal_dopamine_level2.41593153
14MP0002938_white_spotting2.35774189
15MP0005330_cardiomyopathy2.23532398
16MP0010030_abnormal_orbit_morphology2.21374267
17MP0002822_catalepsy2.18542871
18MP0006276_abnormal_autonomic_nervous2.16328683
19MP0000749_muscle_degeneration2.15862861
20MP0000566_synostosis2.13845614
21MP0001440_abnormal_grooming_behavior1.99698783
22MP0009745_abnormal_behavioral_response1.95609225
23MP0002272_abnormal_nervous_system1.91487319
24MP0006035_abnormal_mitochondrial_morpho1.90216100
25MP0002736_abnormal_nociception_after1.89683342
26MP0002064_seizures1.87835782
27MP0004484_altered_response_of1.87194982
28MP0003137_abnormal_impulse_conducting1.86560588
29MP0004145_abnormal_muscle_electrophysio1.80472434
30MP0003635_abnormal_synaptic_transmissio1.79204455
31MP0002972_abnormal_cardiac_muscle1.78961698
32MP0009046_muscle_twitch1.78140250
33MP0001968_abnormal_touch/_nociception1.75563711
34MP0004957_abnormal_blastocyst_morpholog1.74335840
35MP0006292_abnormal_olfactory_placode1.73394387
36MP0004142_abnormal_muscle_tone1.71793208
37MP0009697_abnormal_copulation1.70628257
38MP0008058_abnormal_DNA_repair1.64156977
39MP0004085_abnormal_heartbeat1.59312575
40MP0005620_abnormal_muscle_contractility1.59072058
41MP0004043_abnormal_pH_regulation1.58250920
42MP0002572_abnormal_emotion/affect_behav1.57860086
43MP0004924_abnormal_behavior1.51885915
44MP0005386_behavior/neurological_phenoty1.51885915
45MP0003011_delayed_dark_adaptation1.50358634
46MP0001486_abnormal_startle_reflex1.49990787
47MP0003718_maternal_effect1.44006986
48MP0001984_abnormal_olfaction1.39344927
49MP0002063_abnormal_learning/memory/cond1.38535951
50MP0008775_abnormal_heart_ventricle1.38336197
51MP0004270_analgesia1.37632913
52MP0004859_abnormal_synaptic_plasticity1.37019126
53MP0003329_amyloid_beta_deposits1.36599110
54MP0003950_abnormal_plasma_membrane1.36541334
55MP0001501_abnormal_sleep_pattern1.35130224
56MP0005408_hypopigmentation1.35020449
57MP0002735_abnormal_chemical_nociception1.34810263
58MP0000920_abnormal_myelination1.32380731
59MP0002734_abnormal_mechanical_nocicepti1.32295672
60MP0002332_abnormal_exercise_endurance1.31273575
61MP0002106_abnormal_muscle_physiology1.29205761
62MP0002067_abnormal_sensory_capabilities1.28319221
63MP0002638_abnormal_pupillary_reflex1.27113917
64MP0001970_abnormal_pain_threshold1.26248376
65MP0006138_congestive_heart_failure1.25665266
66MP0003136_yellow_coat_color1.25304215
67MP0010094_abnormal_chromosome_stability1.24753662
68MP0000747_muscle_weakness1.24338946
69MP0008995_early_reproductive_senescence1.24291783
70MP0000013_abnormal_adipose_tissue1.23766764
71MP0003315_abnormal_perineum_morphology1.22950670
72MP0000750_abnormal_muscle_regeneration1.21325810
73MP0004147_increased_porphyrin_level1.21176037
74MP0001544_abnormal_cardiovascular_syste1.18904257
75MP0005385_cardiovascular_system_phenoty1.18904257
76MP0003786_premature_aging1.18768026
77MP0003806_abnormal_nucleotide_metabolis1.16948525
78MP0004087_abnormal_muscle_fiber1.15218527
79MP0008932_abnormal_embryonic_tissue1.14254931
80MP0005535_abnormal_body_temperature1.13313077
81MP0000579_abnormal_nail_morphology1.12589167
82MP0005409_darkened_coat_color1.10989775
83MP0001346_abnormal_lacrimal_gland1.10959330
84MP0001485_abnormal_pinna_reflex1.10831703
85MP0001727_abnormal_embryo_implantation1.10349054
86MP0005369_muscle_phenotype1.08764646
87MP0003693_abnormal_embryo_hatching1.07696216
88MP0003077_abnormal_cell_cycle1.06973574
89MP0008875_abnormal_xenobiotic_pharmacok1.04409024
90MP0002234_abnormal_pharynx_morphology1.03361923
91MP0005187_abnormal_penis_morphology1.02619743
92MP0002090_abnormal_vision1.02135501
93MP0001293_anophthalmia1.01312628
94MP0002733_abnormal_thermal_nociception1.00810593
95MP0004742_abnormal_vestibular_system0.98961244
96MP0002139_abnormal_hepatobiliary_system0.98243186
97MP0005551_abnormal_eye_electrophysiolog0.98163066
98MP0006072_abnormal_retinal_apoptosis0.97829594
99MP0005084_abnormal_gallbladder_morpholo0.97730148
100MP0002697_abnormal_eye_size0.97654148
101MP0003195_calcinosis0.97220854
102MP0005423_abnormal_somatic_nervous0.96145903
103MP0001299_abnormal_eye_distance/0.95801394
104MP0000230_abnormal_systemic_arterial0.94601488
105MP0003937_abnormal_limbs/digits/tail_de0.93875720
106MP0002163_abnormal_gland_morphology0.93420140
107MP0002160_abnormal_reproductive_system0.92459778
108MP0008872_abnormal_physiological_respon0.90540368
109MP0002127_abnormal_cardiovascular_syste0.90508400
110MP0000358_abnormal_cell_content/0.89684319
111MP0002066_abnormal_motor_capabilities/c0.88927736
112MP0005165_increased_susceptibility_to0.88546568
113MP0005379_endocrine/exocrine_gland_phen0.88483631
114MP0000759_abnormal_skeletal_muscle0.88070832
115MP0000762_abnormal_tongue_morphology0.87889735
116MP0002229_neurodegeneration0.87431175
117MP0004130_abnormal_muscle_cell0.87108977
118MP0003122_maternal_imprinting0.86732041
119MP0003111_abnormal_nucleus_morphology0.86591249
120MP0000778_abnormal_nervous_system0.86452999
121MP0000647_abnormal_sebaceous_gland0.85768432
122MP0002277_abnormal_respiratory_mucosa0.85763351
123MP0002184_abnormal_innervation0.84935522
124MP0005266_abnormal_metabolism0.84592161
125MP0005171_absent_coat_pigmentation0.83933579
126MP0002095_abnormal_skin_pigmentation0.83540815
127MP0000631_abnormal_neuroendocrine_gland0.83053281
128MP0005253_abnormal_eye_physiology0.81067840
129MP0003123_paternal_imprinting0.80775381
130MP0002557_abnormal_social/conspecific_i0.80638669
131MP0005636_abnormal_mineral_homeostasis0.79510190
132MP0001664_abnormal_digestion0.78506904
133MP0001764_abnormal_homeostasis0.78472202
134MP0003567_abnormal_fetal_cardiomyocyte0.77432432
135MP0002876_abnormal_thyroid_physiology0.77178444
136MP0002269_muscular_atrophy0.76947577
137MP0005451_abnormal_body_composition0.76606111
138MP0010386_abnormal_urinary_bladder0.76587674
139MP0005332_abnormal_amino_acid0.76219649
140MP0003938_abnormal_ear_development0.74307959
141MP0003221_abnormal_cardiomyocyte_apopto0.72068782
142MP0002282_abnormal_trachea_morphology0.70937514
143MP0000537_abnormal_urethra_morphology0.70667492
144MP0003283_abnormal_digestive_organ0.69881652
145MP0002295_abnormal_pulmonary_circulatio0.68635056
146MP0003186_abnormal_redox_activity0.65995525
147MP0002882_abnormal_neuron_morphology0.65791453

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.74817238
2Abnormal mitochondria in muscle tissue (HP:0008316)7.15418912
3Progressive macrocephaly (HP:0004481)6.60726168
4Mitochondrial inheritance (HP:0001427)6.52000145
5Acute encephalopathy (HP:0006846)6.48806614
6Increased CSF lactate (HP:0002490)5.60045122
7Hepatocellular necrosis (HP:0001404)5.47307155
8Hepatic necrosis (HP:0002605)5.08203090
9Increased hepatocellular lipid droplets (HP:0006565)4.97468747
10Cerebral edema (HP:0002181)4.91051222
11Lipid accumulation in hepatocytes (HP:0006561)4.68108614
12Reticulocytopenia (HP:0001896)4.60611824
13Increased intramyocellular lipid droplets (HP:0012240)4.30239711
14Increased serum pyruvate (HP:0003542)4.27523641
15Abnormality of glycolysis (HP:0004366)4.27523641
16Renal Fanconi syndrome (HP:0001994)4.18918380
17Respiratory failure (HP:0002878)4.05370134
18Exercise intolerance (HP:0003546)4.02353977
19Optic disc pallor (HP:0000543)3.98905295
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.98637461
21Leukodystrophy (HP:0002415)3.94246731
22Lactic acidosis (HP:0003128)3.92745639
23Increased muscle lipid content (HP:0009058)3.91928904
24Sudden death (HP:0001699)3.54345941
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.46456559
26Muscle hypertrophy of the lower extremities (HP:0008968)3.41748305
27Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.41669640
28Decreased activity of mitochondrial respiratory chain (HP:0008972)3.41669640
29Calf muscle hypertrophy (HP:0008981)3.35271176
303-Methylglutaconic aciduria (HP:0003535)3.34787351
31Increased serum lactate (HP:0002151)3.31337982
32Congenital, generalized hypertrichosis (HP:0004540)3.00710015
33Pheochromocytoma (HP:0002666)2.98570289
34Neuroendocrine neoplasm (HP:0100634)2.96734796
35Pallor (HP:0000980)2.94891737
36Exertional dyspnea (HP:0002875)2.89734371
37Abnormality of cells of the erythroid lineage (HP:0012130)2.89309751
38Oral leukoplakia (HP:0002745)2.85928864
39Respiratory difficulties (HP:0002880)2.82811427
40X-linked dominant inheritance (HP:0001423)2.80175964
41Abnormality of renal resorption (HP:0011038)2.74990854
42Generalized aminoaciduria (HP:0002909)2.61473977
43Palpitations (HP:0001962)2.60781565
44Lethargy (HP:0001254)2.56309388
45CNS demyelination (HP:0007305)2.51314293
46Abnormality of urine glucose concentration (HP:0011016)2.51245404
47Glycosuria (HP:0003076)2.51245404
48Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.45335476
49Ventricular tachycardia (HP:0004756)2.43631089
50Abnormal number of erythroid precursors (HP:0012131)2.43582781
51Focal motor seizures (HP:0011153)2.42721564
52Exercise-induced myalgia (HP:0003738)2.40677436
53Emotional lability (HP:0000712)2.38742364
54Syncope (HP:0001279)2.35901416
55Abnormality of the calf musculature (HP:0001430)2.35617129
56Nemaline bodies (HP:0003798)2.33704094
57Conjunctival hamartoma (HP:0100780)2.30657144
58Muscle fiber inclusion bodies (HP:0100299)2.26526998
59Amniotic constriction ring (HP:0009775)2.26070104
60Abnormality of placental membranes (HP:0011409)2.26070104
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.25457436
62Dicarboxylic aciduria (HP:0003215)2.25457436
63Myokymia (HP:0002411)2.25101994
64Parakeratosis (HP:0001036)2.23989137
65Exercise-induced muscle cramps (HP:0003710)2.23371572
66Type I transferrin isoform profile (HP:0003642)2.22932697
67Cerebral hemorrhage (HP:0001342)2.21169994
68Hyperphosphaturia (HP:0003109)2.19982165
69Myoglobinuria (HP:0002913)2.19507943
70Muscle fiber splitting (HP:0003555)2.19300550
71Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.19079219
72Aplasia/Hypoplasia of the sacrum (HP:0008517)2.18965310
73Methylmalonic aciduria (HP:0012120)2.18248453
74Methylmalonic acidemia (HP:0002912)2.15398205
75Microvesicular hepatic steatosis (HP:0001414)2.14498181
76Abnormality of alanine metabolism (HP:0010916)2.13527770
77Hyperalaninemia (HP:0003348)2.13527770
78Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13527770
79Atrial fibrillation (HP:0005110)2.09498850
80Vomiting (HP:0002013)2.05018091
81Concave nail (HP:0001598)2.02788695
82Prolonged QT interval (HP:0001657)2.02746602
83Supraventricular tachycardia (HP:0004755)2.02645364
84Primary atrial arrhythmia (HP:0001692)1.99932118
85Myotonia (HP:0002486)1.99668767
86Macrocytic anemia (HP:0001972)1.98552605
87Sensory axonal neuropathy (HP:0003390)1.96431700
88Hyperventilation (HP:0002883)1.96251086
89Supraventricular arrhythmia (HP:0005115)1.95044501
90Ragged-red muscle fibers (HP:0003200)1.92880863
91Lipoatrophy (HP:0100578)1.92019106
92Aplastic anemia (HP:0001915)1.90779467
93Abnormal urine phosphate concentration (HP:0012599)1.89802602
94Abnormality of serum amino acid levels (HP:0003112)1.86101144
95Ketoacidosis (HP:0001993)1.86041996
96Rhabdomyolysis (HP:0003201)1.85481890
97Stenosis of the external auditory canal (HP:0000402)1.84799982
98Hyperglycinemia (HP:0002154)1.83408326
99Partial duplication of thumb phalanx (HP:0009944)1.81954626
100Muscle stiffness (HP:0003552)1.81619533
101Hypoplastic left heart (HP:0004383)1.78448336
102Gliosis (HP:0002171)1.78170693
103Dilated cardiomyopathy (HP:0001644)1.77965777
104Anxiety (HP:0000739)1.77430896
105Hypothermia (HP:0002045)1.77350594
106Partial duplication of the phalanx of hand (HP:0009999)1.76507967
107Atonic seizures (HP:0010819)1.76339759
108Degeneration of the lateral corticospinal tracts (HP:0002314)1.74135877
109Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.74135877
110Reduced antithrombin III activity (HP:0001976)1.72281541
111Congenital ichthyosiform erythroderma (HP:0007431)1.72190025
112Blindness (HP:0000618)1.72111643
113Septo-optic dysplasia (HP:0100842)1.70041076
114Abnormality of methionine metabolism (HP:0010901)1.69037085
115Retinal dysplasia (HP:0007973)1.66523935
116Gout (HP:0001997)1.65284632
117Degeneration of anterior horn cells (HP:0002398)1.65162112
118Abnormality of the anterior horn cell (HP:0006802)1.65162112
119Colon cancer (HP:0003003)1.64674267
120EMG: myopathic abnormalities (HP:0003458)1.64670799
121Abnormal pupillary function (HP:0007686)1.64055229
122Abnormality of fatty-acid metabolism (HP:0004359)1.63521956
123Athetosis (HP:0002305)1.63069680
124Delusions (HP:0000746)1.62531903
125Left ventricular hypertrophy (HP:0001712)1.62513541
126Renal tubular dysfunction (HP:0000124)1.62119772
127Absent septum pellucidum (HP:0001331)1.62050234
128Hypoplasia of the pons (HP:0012110)1.61541458
129Metabolic acidosis (HP:0001942)1.60958260
130Abnormality of the pons (HP:0007361)1.58075608
131Woolly hair (HP:0002224)1.57959196
132Absent thumb (HP:0009777)1.57945604
133Abnormal gallbladder physiology (HP:0012438)1.57926100
134Triphalangeal thumb (HP:0001199)1.55488321
135Megaloblastic anemia (HP:0001889)1.54957987
136Sparse eyelashes (HP:0000653)1.54736271
137Hypoglycemic coma (HP:0001325)1.54665991
138Nausea (HP:0002018)1.53578428
139Progressive muscle weakness (HP:0003323)1.51761145
140Depressed nasal ridge (HP:0000457)1.50313592

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.10209849
2ZAK3.53402105
3MYLK3.43486820
4STK393.41009121
5NME13.34506241
6MAP3K123.32602645
7GRK72.53594578
8WNK42.53201667
9OBSCN2.47953176
10OXSR12.46577721
11NME22.36395951
12MST42.14017181
13ARAF2.13426717
14PNCK2.10252040
15EPHA42.05896483
16CASK2.00220428
17MUSK2.00135624
18CDC71.99839297
19NEK11.85220054
20PDK31.84767712
21PDK41.84767712
22CDK191.82520686
23STK161.82509859
24GRK51.71375302
25BCKDK1.68290485
26MAP2K71.63732436
27SRPK11.63535030
28MAP3K41.61244045
29PHKG11.59333907
30PHKG21.59333907
31CAMK2D1.55051907
32PBK1.51824667
33DYRK31.51717715
34PIK3CA1.43808999
35MAPKAPK51.35690587
36TTK1.35673216
37CAMK2A1.34149843
38CAMK2B1.33076976
39EPHB21.31515463
40BCR1.29386245
41NTRK31.27278199
42PLK31.25400668
43ILK1.22265611
44PLK21.21782033
45LMTK21.21523265
46PTK2B1.20716164
47PDK21.19499145
48FGR1.17965234
49WEE11.17767358
50RIPK41.17460119
51TNIK1.17090381
52PKN11.11408625
53MAP2K41.09674390
54ROCK21.08761547
55LIMK11.07796495
56AURKB1.06150693
57UHMK11.03807221
58CAMK2G1.03734881
59BMPR21.02396683
60DAPK31.00918555
61EIF2AK11.00067239
62TTN0.99942645
63EPHA20.94829239
64VRK10.94221454
65CCNB10.94002091
66CHEK20.93635819
67GRK60.93340146
68PAK30.92430573
69PLK40.92049022
70PLK10.91960530
71WNK30.91594381
72AURKA0.91001824
73PRKCE0.90206484
74CDK80.89086558
75RPS6KA50.87328872
76INSRR0.86981460
77ADRBK10.86876686
78ADRBK20.85725395
79EIF2AK30.85705042
80PAK40.84740065
81TAF10.81892339
82TSSK60.81591177
83STK40.78719437
84SCYL20.77122664
85PRKACA0.74768750
86BRSK20.73594745
87CSNK1G30.72849771
88BMPR1B0.71974693
89TIE10.71131972
90TLK10.71107692
91TESK10.70265165
92PINK10.69886003
93STK38L0.69586910
94MAP4K20.66474922
95STK240.66268765
96MINK10.66211593
97LRRK20.64328724
98MAPK120.63630223
99CSNK2A10.63573337
100BRAF0.61100246
101MARK10.61030197
102CDK50.60958399
103ERBB30.60299711
104ABL20.59659416
105PRKCG0.56542187
106LATS20.55958571
107BUB10.55068705
108MAPK130.54842714
109MST1R0.54424593
110PRKCQ0.53990117
111BRSK10.53576604
112WNK10.53339439
113KDR0.51890702
114FES0.51281196
115PRKD10.49069385
116CDK140.48271658
117NEK20.47647148
118PRKCI0.47586465
119PASK0.47246639
120DYRK20.47031726
121MAPKAPK30.46259504
122CSNK1E0.46041900
123RPS6KB20.45384944
124CSNK1G20.45343762
125CSNK1A1L0.44982700
126NTRK10.43627892
127AKT20.43583213
128DAPK10.43398790
129ROCK10.41796244
130NUAK10.40984063
131PIM20.40805966
132PRKACB0.40739628
133CAMK10.40505701
134NTRK20.40471775
135PIK3CG0.39756789
136CDK150.37916547
137PRKG10.37862642
138CDK180.37538787
139PRKCA0.37282374
140CDK11A0.36522751
141MAP3K90.35847426
142MAPK150.35845643
143GRK10.33252393
144CSNK1G10.31176382
145CSNK2A20.30091662
146DAPK20.29129417

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.55053955
2Parkinsons disease_Homo sapiens_hsa050125.58477372
3Alzheimers disease_Homo sapiens_hsa050104.35860335
4Huntingtons disease_Homo sapiens_hsa050163.82456551
5Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.59222066
6Cardiac muscle contraction_Homo sapiens_hsa042603.56897934
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.95808451
8Ribosome_Homo sapiens_hsa030102.90352498
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.37833326
10Proteasome_Homo sapiens_hsa030502.21077751
11Mismatch repair_Homo sapiens_hsa034302.04171090
12Fatty acid elongation_Homo sapiens_hsa000622.03446760
13DNA replication_Homo sapiens_hsa030301.91238822
14Collecting duct acid secretion_Homo sapiens_hsa049661.88086780
15Propanoate metabolism_Homo sapiens_hsa006401.87554762
16Protein export_Homo sapiens_hsa030601.72437313
17Homologous recombination_Homo sapiens_hsa034401.70585802
18Sulfur metabolism_Homo sapiens_hsa009201.70538127
19Pyruvate metabolism_Homo sapiens_hsa006201.63311426
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59436368
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.55837064
22Butanoate metabolism_Homo sapiens_hsa006501.50065074
23Nucleotide excision repair_Homo sapiens_hsa034201.46984088
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46000926
25Nicotine addiction_Homo sapiens_hsa050331.36066581
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34283613
27Spliceosome_Homo sapiens_hsa030401.32895171
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28591239
29Systemic lupus erythematosus_Homo sapiens_hsa053221.25425559
30Folate biosynthesis_Homo sapiens_hsa007901.18634099
31Carbon metabolism_Homo sapiens_hsa012001.18177755
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18092268
33RNA polymerase_Homo sapiens_hsa030201.11031574
34Vibrio cholerae infection_Homo sapiens_hsa051101.10917742
35One carbon pool by folate_Homo sapiens_hsa006701.09912270
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01697265
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95040730
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93595926
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89416086
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89009319
41Fatty acid degradation_Homo sapiens_hsa000710.88640798
42Basal transcription factors_Homo sapiens_hsa030220.87854560
43Alcoholism_Homo sapiens_hsa050340.86871515
44GABAergic synapse_Homo sapiens_hsa047270.86036661
45RNA transport_Homo sapiens_hsa030130.85214053
46Synaptic vesicle cycle_Homo sapiens_hsa047210.82735910
47Serotonergic synapse_Homo sapiens_hsa047260.82447919
48Fatty acid metabolism_Homo sapiens_hsa012120.82001115
49* Metabolic pathways_Homo sapiens_hsa011000.81877271
50RNA degradation_Homo sapiens_hsa030180.80639104
51Taste transduction_Homo sapiens_hsa047420.79808186
52Base excision repair_Homo sapiens_hsa034100.78269803
53Fanconi anemia pathway_Homo sapiens_hsa034600.77509370
54Phenylalanine metabolism_Homo sapiens_hsa003600.77219388
55Dilated cardiomyopathy_Homo sapiens_hsa054140.76761177
56Tyrosine metabolism_Homo sapiens_hsa003500.74763163
57Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69720903
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67160820
59Morphine addiction_Homo sapiens_hsa050320.65952997
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65579254
61Nitrogen metabolism_Homo sapiens_hsa009100.63566755
62Glutamatergic synapse_Homo sapiens_hsa047240.61832620
63Calcium signaling pathway_Homo sapiens_hsa040200.61462006
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61108456
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60714659
66Circadian entrainment_Homo sapiens_hsa047130.60046876
67Peroxisome_Homo sapiens_hsa041460.59779698
68Glutathione metabolism_Homo sapiens_hsa004800.59673414
69Arginine biosynthesis_Homo sapiens_hsa002200.58136192
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.57535439
71Renin secretion_Homo sapiens_hsa049240.57534896
72Arginine and proline metabolism_Homo sapiens_hsa003300.56022988
73Amphetamine addiction_Homo sapiens_hsa050310.55759649
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55717488
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54555104
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53641904
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53231510
78Ether lipid metabolism_Homo sapiens_hsa005650.53127719
79Salivary secretion_Homo sapiens_hsa049700.52311986
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50842670
81Histidine metabolism_Homo sapiens_hsa003400.50320024
82Linoleic acid metabolism_Homo sapiens_hsa005910.50077437
83Selenocompound metabolism_Homo sapiens_hsa004500.49852807
84Phototransduction_Homo sapiens_hsa047440.49591905
85Steroid biosynthesis_Homo sapiens_hsa001000.49456888
86Dopaminergic synapse_Homo sapiens_hsa047280.49434742
87Gastric acid secretion_Homo sapiens_hsa049710.48149304
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46858844
89beta-Alanine metabolism_Homo sapiens_hsa004100.46641739
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45161245
91Long-term potentiation_Homo sapiens_hsa047200.43412970
92Rheumatoid arthritis_Homo sapiens_hsa053230.43381452
93Cell cycle_Homo sapiens_hsa041100.41689308
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41521679
95Basal cell carcinoma_Homo sapiens_hsa052170.41381658
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.41004843
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.39582684
98Vitamin B6 metabolism_Homo sapiens_hsa007500.39222074
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.39108149
100Chemical carcinogenesis_Homo sapiens_hsa052040.38998002
101Non-homologous end-joining_Homo sapiens_hsa034500.38278990
102Long-term depression_Homo sapiens_hsa047300.37117085
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36665756
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.36542069
105Arachidonic acid metabolism_Homo sapiens_hsa005900.36503233
106Vitamin digestion and absorption_Homo sapiens_hsa049770.34950980
107Olfactory transduction_Homo sapiens_hsa047400.33464392
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33392564
109Pyrimidine metabolism_Homo sapiens_hsa002400.33121135
110Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33045364
111Caffeine metabolism_Homo sapiens_hsa002320.32613879
112Retinol metabolism_Homo sapiens_hsa008300.32248651
113Oxytocin signaling pathway_Homo sapiens_hsa049210.31833956
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30912913
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.30874100
116Purine metabolism_Homo sapiens_hsa002300.29952881
117Pancreatic secretion_Homo sapiens_hsa049720.29705248
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29632668
119Cholinergic synapse_Homo sapiens_hsa047250.27913408
120Cocaine addiction_Homo sapiens_hsa050300.27639339
121Biosynthesis of amino acids_Homo sapiens_hsa012300.27561909
122Tryptophan metabolism_Homo sapiens_hsa003800.26553659
123Galactose metabolism_Homo sapiens_hsa000520.26410552
124Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25392899
125Regulation of autophagy_Homo sapiens_hsa041400.24799613
126PPAR signaling pathway_Homo sapiens_hsa033200.24388700
127Insulin secretion_Homo sapiens_hsa049110.24351252
128N-Glycan biosynthesis_Homo sapiens_hsa005100.23239371
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21860110
130Pentose phosphate pathway_Homo sapiens_hsa000300.21267936
131Sulfur relay system_Homo sapiens_hsa041220.21169370
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.20799203
133Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.19335102
134Fat digestion and absorption_Homo sapiens_hsa049750.16168235
135Gap junction_Homo sapiens_hsa045400.15679237
136Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.14458538
137Fructose and mannose metabolism_Homo sapiens_hsa000510.11793506
138Phagosome_Homo sapiens_hsa041450.10891030
139Mineral absorption_Homo sapiens_hsa049780.10658086
140Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.10004012

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