ATP5G2P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1leukocyte aggregation (GO:0070486)8.26202017
2activation of MAPKKK activity (GO:0000185)7.82169227
3DNA deamination (GO:0045006)6.55764154
4positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)5.98954194
5glycoprotein catabolic process (GO:0006516)5.12584655
6positive regulation of defense response to virus by host (GO:0002230)5.10772904
7rRNA transcription (GO:0009303)4.95550272
8positive regulation of signal transduction by p53 class mediator (GO:1901798)4.85234656
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.79499416
10metallo-sulfur cluster assembly (GO:0031163)4.60445639
11iron-sulfur cluster assembly (GO:0016226)4.60445639
12cytidine metabolic process (GO:0046087)4.40274914
13cytidine catabolic process (GO:0006216)4.40274914
14cytidine deamination (GO:0009972)4.40274914
15positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.31928914
16positive regulation of natural killer cell mediated immunity (GO:0002717)4.20248762
17chaperone-mediated protein transport (GO:0072321)3.99998886
18Arp2/3 complex-mediated actin nucleation (GO:0034314)3.97128335
19piRNA metabolic process (GO:0034587)3.95705921
20regulation of B cell receptor signaling pathway (GO:0050855)3.95156113
21energy coupled proton transport, down electrochemical gradient (GO:0015985)3.75338540
22ATP synthesis coupled proton transport (GO:0015986)3.75338540
23pyrimidine ribonucleoside catabolic process (GO:0046133)3.68014938
24SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)3.63408315
25actin nucleation (GO:0045010)3.53195256
26protein-cofactor linkage (GO:0018065)3.51474376
27regulation of natural killer cell mediated immunity (GO:0002715)3.51197648
28regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.51197648
29positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.49644306
30induction of positive chemotaxis (GO:0050930)3.44536172
31positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.32972836
32regulation of lymphocyte migration (GO:2000401)3.30723221
33regulation of activation of Janus kinase activity (GO:0010533)3.28034552
34indolalkylamine metabolic process (GO:0006586)3.26717743
35endoderm formation (GO:0001706)3.23185222
36regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.23026919
37positive regulation of monocyte chemotaxis (GO:0090026)3.22164092
38positive regulation of cell killing (GO:0031343)3.18049278
39erythrocyte maturation (GO:0043249)3.17922785
40regulation of leukocyte mediated cytotoxicity (GO:0001910)3.15248206
41regulation of mitotic spindle checkpoint (GO:1903504)3.14986079
42regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.14986079
43regulation of regulatory T cell differentiation (GO:0045589)3.14698652
44mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.13157035
45mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.12114962
46negative regulation of mast cell activation (GO:0033004)3.10338287
47regulation of T cell receptor signaling pathway (GO:0050856)3.06628913
48regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)3.02954269
49positive regulation of calcium-mediated signaling (GO:0050850)3.00966538
50regulation of defense response to virus by host (GO:0050691)3.00874228
51DNA methylation involved in gamete generation (GO:0043046)2.99448338
52purine nucleotide salvage (GO:0032261)2.99013514
53I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.98259053
54regulation of cell killing (GO:0031341)2.87204403
55negative regulation by host of viral transcription (GO:0043922)2.86596214
56peroxisome fission (GO:0016559)2.86327997
57male meiosis I (GO:0007141)2.84990092
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.84361981
59mitochondrial respiratory chain complex I assembly (GO:0032981)2.84361981
60NADH dehydrogenase complex assembly (GO:0010257)2.84361981
61hematopoietic stem cell differentiation (GO:0060218)2.84344722
62regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.76745761
63protein complex biogenesis (GO:0070271)2.75470399
64nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.74167198
65positive regulation of prostaglandin secretion (GO:0032308)2.73699664
66water-soluble vitamin biosynthetic process (GO:0042364)2.73278401
67macroautophagy (GO:0016236)2.71746294
68termination of RNA polymerase III transcription (GO:0006386)2.71331718
69transcription elongation from RNA polymerase III promoter (GO:0006385)2.71331718
70behavioral response to nicotine (GO:0035095)2.69848214
71respiratory electron transport chain (GO:0022904)2.67162181
72electron transport chain (GO:0022900)2.67058868
73sequestering of actin monomers (GO:0042989)2.63224389
74cytolysis (GO:0019835)2.61871066
75meiotic chromosome segregation (GO:0045132)2.60361249
76positive regulation of T cell mediated cytotoxicity (GO:0001916)2.59386636
77tryptophan catabolic process (GO:0006569)2.58166670
78indole-containing compound catabolic process (GO:0042436)2.58166670
79indolalkylamine catabolic process (GO:0046218)2.58166670
80fucose catabolic process (GO:0019317)2.57709912
81L-fucose metabolic process (GO:0042354)2.57709912
82L-fucose catabolic process (GO:0042355)2.57709912
83positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.56769217
84kynurenine metabolic process (GO:0070189)2.54412371
85spinal cord development (GO:0021510)2.53909528
86mitochondrial respiratory chain complex assembly (GO:0033108)2.53351340
87pseudouridine synthesis (GO:0001522)2.51669182
88cellular response to interleukin-15 (GO:0071350)2.51646138
89macrophage chemotaxis (GO:0048246)2.50791787
90resolution of meiotic recombination intermediates (GO:0000712)2.49949198
91positive regulation of vascular permeability (GO:0043117)2.49757288
92negative regulation of T cell differentiation in thymus (GO:0033085)2.48612766
93positive regulation of gamma-delta T cell activation (GO:0046645)2.48444911
94reciprocal meiotic recombination (GO:0007131)2.48102210
95reciprocal DNA recombination (GO:0035825)2.48102210
96proteasome assembly (GO:0043248)2.47813138
97hair cell differentiation (GO:0035315)2.44257599
98regulation of action potential (GO:0098900)2.43985424
99regulation of T cell mediated cytotoxicity (GO:0001914)2.42899712
100thrombin receptor signaling pathway (GO:0070493)2.42283104

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.04172037
2EZH2_22144423_ChIP-Seq_EOC_Human3.85353399
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.23644819
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.15028087
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.87329371
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.87309739
7VDR_22108803_ChIP-Seq_LS180_Human2.74518762
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.51325123
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45756879
10ZNF274_21170338_ChIP-Seq_K562_Hela2.37552951
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.18718538
12LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.15707969
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.08231884
14FLI1_27457419_Chip-Seq_LIVER_Mouse1.91740644
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.90526955
16TP53_22573176_ChIP-Seq_HFKS_Human1.85464389
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84448942
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.73651436
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.73496395
20NOTCH1_21737748_ChIP-Seq_TLL_Human1.64985959
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62272240
22GBX2_23144817_ChIP-Seq_PC3_Human1.61265888
23FOXA1_27270436_Chip-Seq_PROSTATE_Human1.61073716
24FOXA1_25329375_ChIP-Seq_VCAP_Human1.61073716
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60738379
26AR_20517297_ChIP-Seq_VCAP_Human1.59520013
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56421215
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54106748
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.52604047
30YY1_21170310_ChIP-Seq_MESCs_Mouse1.48547849
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44554057
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43449139
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.41847622
34GATA3_26560356_Chip-Seq_TH2_Human1.41509868
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39107220
36VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.38995959
37STAT1_20625510_ChIP-Seq_HELA_Human1.37511219
38TAF15_26573619_Chip-Seq_HEK293_Human1.37315081
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.36827471
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.34776664
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34730324
42TAF2_19829295_ChIP-Seq_ESCs_Human1.31059620
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.30957177
44GATA3_21878914_ChIP-Seq_MCF-7_Human1.30820681
45ELF1_20517297_ChIP-Seq_JURKAT_Human1.30357043
46MYC_19829295_ChIP-Seq_ESCs_Human1.26636789
47MYB_26560356_Chip-Seq_TH2_Human1.26359317
48NCOR_22424771_ChIP-Seq_293T_Human1.24613937
49RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.23908326
50EWS_26573619_Chip-Seq_HEK293_Human1.23441072
51GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.22001781
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21782240
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21644386
54FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20539304
55ERA_21632823_ChIP-Seq_H3396_Human1.20451916
56E2F1_20622854_ChIP-Seq_HELA_Human1.19732674
57EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.19401850
58FUS_26573619_Chip-Seq_HEK293_Human1.19257324
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.18417224
60PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.18054674
61VDR_23849224_ChIP-Seq_CD4+_Human1.17321761
62ER_23166858_ChIP-Seq_MCF-7_Human1.16125478
63IRF8_21731497_ChIP-ChIP_J774_Mouse1.15145456
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.15057780
65NANOG_19829295_ChIP-Seq_ESCs_Human1.13770420
66SOX2_19829295_ChIP-Seq_ESCs_Human1.13770420
67P300_19829295_ChIP-Seq_ESCs_Human1.12155805
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11717745
69GATA6_21074721_ChIP-Seq_CACO-2_Human1.09924556
70CRX_20693478_ChIP-Seq_RETINA_Mouse1.09400308
71GATA3_27048872_Chip-Seq_THYMUS_Human1.06482943
72EZH2_27304074_Chip-Seq_ESCs_Mouse1.05949629
73RUNX_20019798_ChIP-Seq_JUKART_Human1.05907772
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05814193
75ERG_20517297_ChIP-Seq_VCAP_Human1.05538350
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05386865
77TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04868277
78AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04836975
79RBPJ_21746931_ChIP-Seq_IB4_Human1.04627391
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04436575
81P53_21459846_ChIP-Seq_SAOS-2_Human1.03992888
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.03853537
83DROSHA_22980978_ChIP-Seq_HELA_Human1.03849362
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03817003
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03472960
86CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.03398689
87FOXP3_21729870_ChIP-Seq_TREG_Human1.03151933
88CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02761663
89GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.02420318
90PHF8_20622853_ChIP-Seq_HELA_Human1.02244648
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01584425
92HOXB7_26014856_ChIP-Seq_BT474_Human0.99637215
93STAT3_18555785_Chip-Seq_ESCs_Mouse0.99231347
94NANOG_20526341_ChIP-Seq_ESCs_Human0.99053741
95PRDM14_20953172_ChIP-Seq_ESCs_Human0.97755325
96CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96385011
97SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95691709
98JARID2_20064375_ChIP-Seq_MESCs_Mouse0.94813460
99CBP_20019798_ChIP-Seq_JUKART_Human0.94808931
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94808931

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005623_abnormal_meninges_morphology6.45553115
2MP0005671_abnormal_response_to4.43259591
3MP0000750_abnormal_muscle_regeneration2.78721201
4MP0000013_abnormal_adipose_tissue2.66554073
5MP0003786_premature_aging2.42368147
6MP0009384_cardiac_valve_regurgitation2.40777737
7MP0005551_abnormal_eye_electrophysiolog2.33129185
8MP0002938_white_spotting2.14271830
9MP0004147_increased_porphyrin_level2.12588883
10MP0002102_abnormal_ear_morphology2.05426917
11MP0009785_altered_susceptibility_to1.95949597
12MP0002638_abnormal_pupillary_reflex1.91714721
13MP0005645_abnormal_hypothalamus_physiol1.85899440
14MP0004145_abnormal_muscle_electrophysio1.84644975
15MP0002163_abnormal_gland_morphology1.78693262
16MP0001905_abnormal_dopamine_level1.77828851
17MP0006276_abnormal_autonomic_nervous1.76378657
18MP0001800_abnormal_humoral_immune1.69022845
19MP0003763_abnormal_thymus_physiology1.64993293
20MP0002933_joint_inflammation1.61799866
21MP0002138_abnormal_hepatobiliary_system1.60075623
22MP0002277_abnormal_respiratory_mucosa1.58841227
23MP0001501_abnormal_sleep_pattern1.51353216
24MP0002837_dystrophic_cardiac_calcinosis1.50978590
25MP0000569_abnormal_digit_pigmentation1.48531772
26MP0006072_abnormal_retinal_apoptosis1.45133471
27MP0005000_abnormal_immune_tolerance1.43152339
28MP0000372_irregular_coat_pigmentation1.42572199
29MP0001835_abnormal_antigen_presentation1.41754067
30MP0005387_immune_system_phenotype1.40454776
31MP0001790_abnormal_immune_system1.40454776
32MP0002876_abnormal_thyroid_physiology1.40414361
33MP0009745_abnormal_behavioral_response1.38807574
34MP0009379_abnormal_foot_pigmentation1.36164774
35MP0003195_calcinosis1.36083155
36MP0005379_endocrine/exocrine_gland_phen1.34975984
37MP0002723_abnormal_immune_serum1.34590639
38MP0009764_decreased_sensitivity_to1.34550999
39MP0004885_abnormal_endolymph1.33651487
40MP0003137_abnormal_impulse_conducting1.33544824
41MP0002420_abnormal_adaptive_immunity1.31991026
42MP0005646_abnormal_pituitary_gland1.31179778
43MP0001819_abnormal_immune_cell1.28682293
44MP0008875_abnormal_xenobiotic_pharmacok1.28672409
45MP0000858_altered_metastatic_potential1.27324616
46MP0000685_abnormal_immune_system1.27273671
47MP0004947_skin_inflammation1.25470635
48MP0008872_abnormal_physiological_respon1.23931637
49MP0003011_delayed_dark_adaptation1.22474952
50MP0001968_abnormal_touch/_nociception1.18449991
51MP0002272_abnormal_nervous_system1.17447659
52MP0003724_increased_susceptibility_to1.16477398
53MP0009333_abnormal_splenocyte_physiolog1.15356509
54MP0002148_abnormal_hypersensitivity_rea1.14068244
55MP0002452_abnormal_antigen_presenting1.13896459
56MP0005025_abnormal_response_to1.13485952
57MP0009046_muscle_twitch1.12494543
58MP0002067_abnormal_sensory_capabilities1.11756014
59MP0008775_abnormal_heart_ventricle1.09098392
60MP0005584_abnormal_enzyme/coenzyme_acti1.07726192
61MP0003880_abnormal_central_pattern1.07714711
62MP0003646_muscle_fatigue1.05463308
63MP0003866_abnormal_defecation1.04851440
64MP0006082_CNS_inflammation1.02054359
65MP0000762_abnormal_tongue_morphology1.00832176
66MP0005410_abnormal_fertilization0.96308054
67MP0002733_abnormal_thermal_nociception0.96058553
68MP0008877_abnormal_DNA_methylation0.93933480
69MP0002166_altered_tumor_susceptibility0.91939683
70MP0006292_abnormal_olfactory_placode0.90450309
71MP0003436_decreased_susceptibility_to0.89997225
72MP0001502_abnormal_circadian_rhythm0.88175296
73MP0001485_abnormal_pinna_reflex0.86987719
74MP0002572_abnormal_emotion/affect_behav0.86893631
75MP0002064_seizures0.86828683
76MP0005195_abnormal_posterior_eye0.83345659
77MP0001486_abnormal_startle_reflex0.83095593
78MP0008770_decreased_survivor_rate0.82548516
79MP0002177_abnormal_outer_ear0.80645903
80MP0005389_reproductive_system_phenotype0.80461547
81MP0004742_abnormal_vestibular_system0.79652245
82MP0002736_abnormal_nociception_after0.79068035
83MP0000689_abnormal_spleen_morphology0.77439954
84MP0003806_abnormal_nucleotide_metabolis0.77438281
85MP0006036_abnormal_mitochondrial_physio0.77025666
86MP0001440_abnormal_grooming_behavior0.76274118
87MP0000230_abnormal_systemic_arterial0.75814063
88MP0001970_abnormal_pain_threshold0.75487637
89MP0001986_abnormal_taste_sensitivity0.75283129
90MP0000716_abnormal_immune_system0.74396318
91MP0005253_abnormal_eye_physiology0.74258507
92MP0003787_abnormal_imprinting0.73957274
93MP0002006_tumorigenesis0.73718968
94MP0002095_abnormal_skin_pigmentation0.73519198
95MP0003638_abnormal_response/metabolism_0.73247659
96MP0003879_abnormal_hair_cell0.73067758
97MP0002160_abnormal_reproductive_system0.72928028
98MP0004142_abnormal_muscle_tone0.71977325
99MP0004130_abnormal_muscle_cell0.71391201
100MP0001845_abnormal_inflammatory_respons0.70971897

Predicted human phenotypes

RankGene SetZ-score
1Cerebellar dysplasia (HP:0007033)8.85570146
2Type II lissencephaly (HP:0007260)8.83351664
3Retinal atrophy (HP:0001105)8.58555247
4Retinal dysplasia (HP:0007973)7.60947332
5Hypoplasia of the pons (HP:0012110)6.67488054
6Decreased electroretinogram (ERG) amplitude (HP:0000654)6.63612861
7Abnormality of the pons (HP:0007361)6.46856247
8Fatigue (HP:0012378)5.85654479
9Abolished electroretinogram (ERG) (HP:0000550)5.51894111
10Aplasia/Hypoplasia affecting the retina (HP:0008061)4.99989264
11IgG deficiency (HP:0004315)4.53966932
12Buphthalmos (HP:0000557)4.36773145
13Difficulty climbing stairs (HP:0003551)4.18420342
14Increased IgM level (HP:0003496)3.89424760
15Severe muscular hypotonia (HP:0006829)3.80732801
16Lissencephaly (HP:0001339)3.38730674
17Elevated erythrocyte sedimentation rate (HP:0003565)3.05594012
18Entropion (HP:0000621)3.02299435
19Pachygyria (HP:0001302)2.90481996
20Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.89904749
21Megalocornea (HP:0000485)2.73070952
22Aplasia/Hypoplasia of the brainstem (HP:0007362)2.67968878
23Hypoplasia of the brainstem (HP:0002365)2.67968878
24Intellectual disability, profound (HP:0002187)2.67364949
25Abnormality of midbrain morphology (HP:0002418)2.65563502
26Molar tooth sign on MRI (HP:0002419)2.65563502
27Pancreatic cysts (HP:0001737)2.58378123
28Mesangial abnormality (HP:0001966)2.51086228
293-Methylglutaconic aciduria (HP:0003535)2.51066792
30Pancreatic fibrosis (HP:0100732)2.50714530
31Generalized hypotonia (HP:0001290)2.43493335
32Abnormality of DNA repair (HP:0003254)2.42877581
33Abnormality of the vitreous humor (HP:0004327)2.42584526
34True hermaphroditism (HP:0010459)2.42490049
35Congenital stationary night blindness (HP:0007642)2.42090984
36Severe global developmental delay (HP:0011344)2.40824009
37Congenital glaucoma (HP:0001087)2.35928090
38Nephronophthisis (HP:0000090)2.26548355
39Papilledema (HP:0001085)2.26240353
40Non-midline cleft lip (HP:0100335)2.23140832
41Poikiloderma (HP:0001029)2.21754274
42Meningocele (HP:0002435)2.19899145
43Abnormality of the prostate (HP:0008775)2.18110025
44Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.16360195
45Decreased subcutaneous fat (HP:0001002)2.14213877
46Erythroderma (HP:0001019)2.10778645
47Abnormal albumin level (HP:0012116)2.08104439
48Hypoalbuminemia (HP:0003073)2.08104439
49T lymphocytopenia (HP:0005403)2.07484007
50Abnormality of the renal cortex (HP:0011035)2.07381223
51Abnormality of T cell number (HP:0011839)2.05909698
52Generalized muscle weakness (HP:0003324)1.98542439
53Polydipsia (HP:0001959)1.97774858
54Abnormal drinking behavior (HP:0030082)1.97774858
55Fragile nails (HP:0001808)1.94708498
56Keratitis (HP:0000491)1.92081631
57Eosinophilia (HP:0001880)1.91074205
58Abnormality of vision evoked potentials (HP:0000649)1.90997926
59Abnormality of the renal medulla (HP:0100957)1.85544265
60Hypoproteinemia (HP:0003075)1.82578344
61Brittle hair (HP:0002299)1.82088363
62Stomatitis (HP:0010280)1.81899722
63Encephalitis (HP:0002383)1.80940181
64Hepatocellular necrosis (HP:0001404)1.78501448
65Abnormality of B cell number (HP:0010975)1.78441867
66Mitochondrial inheritance (HP:0001427)1.78247384
67Polyuria (HP:0000103)1.76323206
68Medial flaring of the eyebrow (HP:0010747)1.75937777
69Tubular atrophy (HP:0000092)1.75029402
70Attenuation of retinal blood vessels (HP:0007843)1.73691069
71Abnormality of eosinophils (HP:0001879)1.73632288
72Polymicrogyria (HP:0002126)1.73585150
73Asplenia (HP:0001746)1.72750062
74Aplastic anemia (HP:0001915)1.69932612
75Gowers sign (HP:0003391)1.69549143
76Congenital ichthyosiform erythroderma (HP:0007431)1.69206019
77Keratoconus (HP:0000563)1.69067368
78Increased corneal curvature (HP:0100692)1.69067368
79CNS demyelination (HP:0007305)1.67498856
80Aplasia/Hypoplasia of the spleen (HP:0010451)1.67101350
81Abnormality of T cells (HP:0002843)1.64725724
82Chronic hepatic failure (HP:0100626)1.64424189
83Acute necrotizing encephalopathy (HP:0006965)1.62423004
84Sclerocornea (HP:0000647)1.61453957
85Hepatic necrosis (HP:0002605)1.61301597
86Increased CSF lactate (HP:0002490)1.61198812
87Cerebral hypomyelination (HP:0006808)1.59920485
88Occipital encephalocele (HP:0002085)1.59874770
89Pallor (HP:0000980)1.59854394
90Decreased central vision (HP:0007663)1.59198434
91Dandy-Walker malformation (HP:0001305)1.57873216
92Absent rod-and cone-mediated responses on ERG (HP:0007688)1.57286745
93Muscular dystrophy (HP:0003560)1.55981951
94Hypergammaglobulinemia (HP:0010702)1.55238273
95Holoprosencephaly (HP:0001360)1.53851546
96Pendular nystagmus (HP:0012043)1.53645166
97B lymphocytopenia (HP:0010976)1.53555095
98Aplasia/Hypoplasia involving the musculature (HP:0001460)1.53359751
99Conical tooth (HP:0000698)1.52900486
100Iris coloboma (HP:0000612)1.49910283

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK105.41717207
2MARK35.35794037
3TLK14.08865684
4TXK3.83659017
5MAP4K22.72391309
6ADRBK22.70075638
7ZAK2.63024449
8KDR2.57700088
9PTK2B2.53165618
10BCKDK2.45666345
11FRK2.30763647
12PIM12.19041927
13TAOK31.99095816
14MAP4K11.77687361
15GRK11.71710185
16STK111.62274519
17WNK31.60121354
18TESK21.56229615
19TIE11.39088705
20TEC1.34442912
21SYK1.31249353
22VRK21.28186416
23ITK1.26986064
24PRKCH1.26800195
25VRK11.18511937
26MAP2K21.10723839
27LMTK21.09115138
28CDK191.05496350
29CAMKK21.01596337
30PIK3CA1.01449083
31MAP3K120.94250175
32GRK60.91912313
33RPS6KA40.89144436
34PINK10.86051163
35RPS6KA50.85600911
36IKBKB0.84011534
37NTRK20.83842742
38SIK20.83679005
39KIT0.83488477
40MAP3K40.81310859
41LCK0.81099881
42FES0.80332705
43NUAK10.79075746
44DAPK20.75270752
45PKN10.75022628
46PRKCQ0.73264293
47INSRR0.69665971
48DAPK10.68143325
49GRK70.67090594
50LYN0.65926232
51MAPK130.64709978
52DYRK20.64352769
53PHKG10.63780382
54PHKG20.63780382
55MAP2K60.63557536
56MAPKAPK50.63019891
57CSNK1G30.58757148
58ZAP700.57407510
59GRK50.57243021
60MAP3K110.57033908
61TSSK60.55567248
62CSNK1G20.55054115
63PRKCE0.53542097
64MARK10.53064319
65EIF2AK30.51710535
66BTK0.50228970
67MUSK0.48774036
68ADRBK10.47605071
69CLK10.47045845
70IGF1R0.45586978
71OBSCN0.45453936
72CAMK2A0.45233966
73CSNK1G10.43548936
74NME10.42740378
75EIF2AK20.40081977
76GSK3A0.39628086
77EPHA30.39399967
78DYRK1A0.38633470
79PRKACA0.38025520
80PRKCA0.37998016
81MAP2K70.35671698
82FYN0.35501755
83PRKCD0.35158306
84CSK0.34576282
85MST40.33911521
86OXSR10.33620336
87LIMK10.33380256
88CSNK1A1L0.33342440
89PLK30.32988089
90NLK0.31529147
91CASK0.31397806
92MAPKAPK30.30869422
93MINK10.29964872
94MAP3K50.29907274
95WNK40.29212853
96EPHA40.28471583
97MAPK110.27672946
98ERBB20.27560365
99CAMK10.26790322
100ABL10.26653288

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.73051018
2Graft-versus-host disease_Homo sapiens_hsa053323.16974416
3Allograft rejection_Homo sapiens_hsa053302.80348662
4Oxidative phosphorylation_Homo sapiens_hsa001902.80314312
5Autoimmune thyroid disease_Homo sapiens_hsa053202.74769026
6Proteasome_Homo sapiens_hsa030502.71111231
7SNARE interactions in vesicular transport_Homo sapiens_hsa041302.67357544
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.36050014
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.35983890
10Asthma_Homo sapiens_hsa053102.28925788
11Parkinsons disease_Homo sapiens_hsa050122.28404995
12Type I diabetes mellitus_Homo sapiens_hsa049402.24657497
13Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.17962496
14Sulfur metabolism_Homo sapiens_hsa009202.10425229
15Antigen processing and presentation_Homo sapiens_hsa046122.03636490
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.98545099
17RNA polymerase_Homo sapiens_hsa030201.85999085
18Ribosome_Homo sapiens_hsa030101.75884441
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.70876831
20Cardiac muscle contraction_Homo sapiens_hsa042601.64717739
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57558998
22Linoleic acid metabolism_Homo sapiens_hsa005911.56738463
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55857778
24Rheumatoid arthritis_Homo sapiens_hsa053231.54749697
25Phototransduction_Homo sapiens_hsa047441.51912080
26Alzheimers disease_Homo sapiens_hsa050101.51000106
27Protein export_Homo sapiens_hsa030601.44647201
28Hematopoietic cell lineage_Homo sapiens_hsa046401.43292933
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.42356296
30Huntingtons disease_Homo sapiens_hsa050161.42194653
31Sulfur relay system_Homo sapiens_hsa041221.36764014
32Butanoate metabolism_Homo sapiens_hsa006501.30339365
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23502728
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17325783
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16300103
36Leishmaniasis_Homo sapiens_hsa051401.12596139
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11062264
38Tryptophan metabolism_Homo sapiens_hsa003801.06218801
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02520996
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01985243
41Peroxisome_Homo sapiens_hsa041461.01465988
42Nicotine addiction_Homo sapiens_hsa050330.98485360
43Ether lipid metabolism_Homo sapiens_hsa005650.91924133
44T cell receptor signaling pathway_Homo sapiens_hsa046600.90035571
45Regulation of autophagy_Homo sapiens_hsa041400.89415091
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.88296000
47Taste transduction_Homo sapiens_hsa047420.84461376
48TNF signaling pathway_Homo sapiens_hsa046680.83485533
49Basal transcription factors_Homo sapiens_hsa030220.83131988
50Caffeine metabolism_Homo sapiens_hsa002320.82120729
51Homologous recombination_Homo sapiens_hsa034400.81435905
52Viral myocarditis_Homo sapiens_hsa054160.77740678
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75371605
54Olfactory transduction_Homo sapiens_hsa047400.72875017
55Collecting duct acid secretion_Homo sapiens_hsa049660.72442418
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72133446
57Arachidonic acid metabolism_Homo sapiens_hsa005900.71666239
58Nitrogen metabolism_Homo sapiens_hsa009100.67963643
59Retinol metabolism_Homo sapiens_hsa008300.66343008
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.65258537
61Pyrimidine metabolism_Homo sapiens_hsa002400.64699920
62Morphine addiction_Homo sapiens_hsa050320.64162489
63Purine metabolism_Homo sapiens_hsa002300.63734950
64Chemical carcinogenesis_Homo sapiens_hsa052040.63284122
65Staphylococcus aureus infection_Homo sapiens_hsa051500.63218263
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60943220
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58272682
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.57624423
69RNA degradation_Homo sapiens_hsa030180.57037525
70Salivary secretion_Homo sapiens_hsa049700.53619473
71Serotonergic synapse_Homo sapiens_hsa047260.53190413
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50478885
73GABAergic synapse_Homo sapiens_hsa047270.49716317
74Herpes simplex infection_Homo sapiens_hsa051680.49676771
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48934697
76Toxoplasmosis_Homo sapiens_hsa051450.47482046
77Fatty acid degradation_Homo sapiens_hsa000710.46500125
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46273337
79Insulin secretion_Homo sapiens_hsa049110.44242319
80Selenocompound metabolism_Homo sapiens_hsa004500.42017188
81Systemic lupus erythematosus_Homo sapiens_hsa053220.38699376
82Dopaminergic synapse_Homo sapiens_hsa047280.38648596
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38256344
84Epstein-Barr virus infection_Homo sapiens_hsa051690.37612486
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37423530
86Metabolic pathways_Homo sapiens_hsa011000.35157360
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33283330
88Glycerolipid metabolism_Homo sapiens_hsa005610.33045549
89Phagosome_Homo sapiens_hsa041450.32958358
90One carbon pool by folate_Homo sapiens_hsa006700.31990008
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31832936
92Nucleotide excision repair_Homo sapiens_hsa034200.31439223
93Circadian entrainment_Homo sapiens_hsa047130.29675244
94p53 signaling pathway_Homo sapiens_hsa041150.29440521
95Fanconi anemia pathway_Homo sapiens_hsa034600.28352034
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27596062
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27534180
98Mineral absorption_Homo sapiens_hsa049780.26877082
99Malaria_Homo sapiens_hsa051440.24630124
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.22956800

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