ATP5G2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). There are three separate genes which encode subunit c of the proton channel and they specify precursors with different import sequences but identical mature proteins. The protein encoded by this gene is one of three precursors of subunit c. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene has multiple pseudogenes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)8.44322909
2translational termination (GO:0006415)8.07819306
3ribosomal small subunit biogenesis (GO:0042274)8.00361859
4ribosomal small subunit assembly (GO:0000028)7.59778450
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.31306840
6cotranslational protein targeting to membrane (GO:0006613)7.25295368
7protein targeting to ER (GO:0045047)7.18907139
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.96644273
9translational elongation (GO:0006414)6.90923258
10establishment of protein localization to endoplasmic reticulum (GO:0072599)6.87183557
11protein localization to endoplasmic reticulum (GO:0070972)6.79679197
12* ATP synthesis coupled proton transport (GO:0015986)6.45021341
13* energy coupled proton transport, down electrochemical gradient (GO:0015985)6.45021341
14viral life cycle (GO:0019058)6.35184917
15cellular protein complex disassembly (GO:0043624)6.30255072
16maturation of SSU-rRNA (GO:0030490)6.07843923
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.05825984
18ribosomal large subunit biogenesis (GO:0042273)5.98670972
19translational initiation (GO:0006413)5.92479844
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.40589548
21protein complex disassembly (GO:0043241)5.38179427
22translation (GO:0006412)5.22840477
23macromolecular complex disassembly (GO:0032984)5.06658139
24respiratory electron transport chain (GO:0022904)5.00406337
25electron transport chain (GO:0022900)4.88858350
26protein targeting to membrane (GO:0006612)4.80286519
27proteasome assembly (GO:0043248)4.54709348
28ribonucleoprotein complex biogenesis (GO:0022613)4.44618861
29nuclear-transcribed mRNA catabolic process (GO:0000956)4.37235978
30DNA deamination (GO:0045006)4.33872277
31establishment of integrated proviral latency (GO:0075713)4.15784187
32mRNA catabolic process (GO:0006402)4.14418038
33NADH dehydrogenase complex assembly (GO:0010257)4.10964802
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.10964802
35mitochondrial respiratory chain complex I assembly (GO:0032981)4.10964802
36negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.03171559
37cellular component biogenesis (GO:0044085)4.02970047
38protein complex biogenesis (GO:0070271)4.00217579
39termination of RNA polymerase III transcription (GO:0006386)3.98580178
40transcription elongation from RNA polymerase III promoter (GO:0006385)3.98580178
41peptidyl-histidine modification (GO:0018202)3.86530224
42protein neddylation (GO:0045116)3.83721830
43RNA catabolic process (GO:0006401)3.76923211
44GTP biosynthetic process (GO:0006183)3.75837659
45negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.75479784
46negative regulation of ligase activity (GO:0051352)3.75479784
47oxidative phosphorylation (GO:0006119)3.75115398
48formation of translation preinitiation complex (GO:0001731)3.74695968
49establishment of protein localization to mitochondrial membrane (GO:0090151)3.74595566
50mitochondrial respiratory chain complex assembly (GO:0033108)3.73957461
51pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.72736974
52DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.71663101
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.68379193
54inner mitochondrial membrane organization (GO:0007007)3.68075140
55intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.62949874
56signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.62949874
57establishment of viral latency (GO:0019043)3.59132539
58signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.57991085
59signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.57991085
60signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.57991085
61regulation of cellular amino acid metabolic process (GO:0006521)3.57891271
62regulation of mitochondrial translation (GO:0070129)3.56921184
63rRNA processing (GO:0006364)3.56142736
64positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.55518402
65chaperone-mediated protein transport (GO:0072321)3.54028304
66* ribonucleoside triphosphate biosynthetic process (GO:0009201)3.51707219
67nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.50432839
68sequestering of actin monomers (GO:0042989)3.50421433
69signal transduction involved in DNA integrity checkpoint (GO:0072401)3.49315675
70signal transduction involved in DNA damage checkpoint (GO:0072422)3.49315675
71regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.49006920
72antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.48396469
73L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.45227794
74cytochrome complex assembly (GO:0017004)3.43903945
75signal transduction involved in cell cycle checkpoint (GO:0072395)3.43900370
76rRNA metabolic process (GO:0016072)3.42411960
77* hydrogen ion transmembrane transport (GO:1902600)3.42280370
78UTP biosynthetic process (GO:0006228)3.40492610
79establishment of protein localization to membrane (GO:0090150)3.40007260
80respiratory chain complex IV assembly (GO:0008535)3.39014870
81anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.38927396
82exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.37555899
83aerobic respiration (GO:0009060)3.36219016
847-methylguanosine mRNA capping (GO:0006370)3.33812440
85telomere maintenance via semi-conservative replication (GO:0032201)3.31772707
86RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.28373971
87tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.28373971
88protein targeting (GO:0006605)3.27815451
89RNA capping (GO:0036260)3.27299731
907-methylguanosine RNA capping (GO:0009452)3.27299731
91protein targeting to mitochondrion (GO:0006626)3.20795473
92cullin deneddylation (GO:0010388)3.17829511
93* nucleoside triphosphate biosynthetic process (GO:0009142)3.14756885
94DNA strand elongation involved in DNA replication (GO:0006271)3.14559016
95deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.13929998
96establishment of protein localization to mitochondrion (GO:0072655)3.11808438
97protein localization to mitochondrion (GO:0070585)3.11424587
98* purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.10681522
99pyrimidine nucleotide catabolic process (GO:0006244)3.10360135
100spliceosomal snRNP assembly (GO:0000387)3.08879506
101transcription-coupled nucleotide-excision repair (GO:0006283)3.08831121
102pseudouridine synthesis (GO:0001522)3.06657473
103pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.05333805
104guanosine-containing compound biosynthetic process (GO:1901070)3.05004097
105pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.04909257
106* purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.04487759
107* purine nucleoside monophosphate biosynthetic process (GO:0009127)3.04487759
108* purine nucleoside triphosphate biosynthetic process (GO:0009145)3.03659805
109establishment of protein localization to organelle (GO:0072594)3.00707605
110DNA strand elongation (GO:0022616)3.00506894
111positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.00467233
112* proton transport (GO:0015992)2.97859017
113CTP metabolic process (GO:0046036)2.95255400
114CTP biosynthetic process (GO:0006241)2.95255400
115pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.95131516
116positive regulation of ligase activity (GO:0051351)2.95088418
117UTP metabolic process (GO:0046051)2.94932644
118base-excision repair, AP site formation (GO:0006285)2.93787487
119protein deneddylation (GO:0000338)2.92855688
120protein localization to membrane (GO:0072657)2.91704065
121* ATP biosynthetic process (GO:0006754)2.91517953
122mitochondrial transport (GO:0006839)2.91454121
123DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.91323679
124* hydrogen transport (GO:0006818)2.90752808
125positive regulation of cell cycle arrest (GO:0071158)2.89352192
126intracellular protein transmembrane import (GO:0044743)2.87006198
127deoxyribonucleotide catabolic process (GO:0009264)2.86148663
128deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.84607729

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.76167091
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.57698517
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.49115584
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.35880270
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.27365836
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.86942007
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.74303442
8* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.74102277
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.65393636
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.42755646
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.38588672
12* CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.22399947
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.18464357
14* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.05006960
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.98608717
16E2F7_22180533_ChIP-Seq_HELA_Human2.89756719
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.83665547
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.79788838
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.74019387
20XRN2_22483619_ChIP-Seq_HELA_Human2.68551618
21DCP1A_22483619_ChIP-Seq_HELA_Human2.52980768
22VDR_23849224_ChIP-Seq_CD4+_Human2.45144524
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.41127978
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.26103569
25* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.20310885
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.20287378
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.13906510
28TTF2_22483619_ChIP-Seq_HELA_Human2.13172878
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11391474
30YY1_21170310_ChIP-Seq_MESCs_Mouse2.09857054
31FOXP3_21729870_ChIP-Seq_TREG_Human2.09851204
32CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.08880268
33ELK1_19687146_ChIP-ChIP_HELA_Human2.05562515
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.98352780
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95900218
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91554302
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.88716133
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.80110091
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.78878598
40* GABP_19822575_ChIP-Seq_HepG2_Human1.78147304
41ELK1_22589737_ChIP-Seq_MCF10A_Human1.76818110
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63879956
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61871256
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61754556
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59001375
46* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52596497
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.52001993
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50319206
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45465897
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43535428
51DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36804439
52KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.36668163
53BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.36643277
54* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27686218
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26729444
56ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23903746
57* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21263734
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19928456
59* FOXP1_21924763_ChIP-Seq_HESCs_Human1.19270163
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.18877439
61* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15709844
62CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.13813847
63MYC_18940864_ChIP-ChIP_HL60_Human1.13448134
64FOXM1_23109430_ChIP-Seq_U2OS_Human1.13441564
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10167816
66* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09419187
67SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.09082194
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08208746
69TET1_21451524_ChIP-Seq_MESCs_Mouse1.06101437
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05901078
71E2F1_21310950_ChIP-Seq_MCF-7_Human1.04741010
72OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03968659
73* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03610585
74* KDM5A_27292631_Chip-Seq_BREAST_Human1.03222501
75* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02916799
76IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00833728
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.00801845
78CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00744768
79HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99847233
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99824762
81* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98280679
82SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98169186
83BP1_19119308_ChIP-ChIP_Hs578T_Human0.96939745
84PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96227651
85CIITA_25753668_ChIP-Seq_RAJI_Human0.95942634
86SPI1_23547873_ChIP-Seq_NB4_Human0.95396206
87CTCF_26484167_Chip-Seq_Bcells_Mouse0.94930384
88* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.94580693
89NOTCH1_21737748_ChIP-Seq_TLL_Human0.94464722
90SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93264228
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91412453
92* SOX17_20123909_ChIP-Seq_XEN_Mouse0.90355136
93STAT1_20625510_ChIP-Seq_HELA_Human0.89401684
94MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.88863662
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88628585
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.87823170
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87657370
98IRF1_19129219_ChIP-ChIP_H3396_Human0.87498413
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86244214
100RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84465143
101ELF1_20517297_ChIP-Seq_JURKAT_Human0.84276079
102DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83888928
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83278281
104EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.81761168
105TFEB_21752829_ChIP-Seq_HELA_Human0.81248409
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80646091
107YY1_22570637_ChIP-Seq_MALME-3M_Human0.79840293
108KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.78887244
109KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.78887244
110KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.78887244
111ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78384293
112BCL6_27268052_Chip-Seq_Bcells_Human0.78072595
113* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77472595
114E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.76876707
115NANOG_16153702_ChIP-ChIP_HESCs_Human0.75866110
116MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.75824869
117STAT3_1855785_ChIP-Seq_MESCs_Mouse0.74406527
118P68_20966046_ChIP-Seq_HELA_Human0.73831442
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.72245626

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.64308077
2MP0003693_abnormal_embryo_hatching3.27705542
3MP0003806_abnormal_nucleotide_metabolis3.06364884
4MP0004957_abnormal_blastocyst_morpholog2.99130044
5MP0003186_abnormal_redox_activity2.87883556
6MP0010030_abnormal_orbit_morphology2.60076932
7MP0001529_abnormal_vocalization2.54075144
8MP0006036_abnormal_mitochondrial_physio2.49780522
9MP0008932_abnormal_embryonic_tissue2.49527098
10MP0008057_abnormal_DNA_replication2.42953210
11MP0002653_abnormal_ependyma_morphology2.18250270
12MP0003077_abnormal_cell_cycle2.15494829
13MP0003136_yellow_coat_color2.09757620
14MP0008995_early_reproductive_senescence2.04545945
15MP0000749_muscle_degeneration1.95439286
16MP0005499_abnormal_olfactory_system1.92936669
17MP0005394_taste/olfaction_phenotype1.92936669
18MP0001905_abnormal_dopamine_level1.88901020
19MP0002837_dystrophic_cardiac_calcinosis1.85417528
20MP0006035_abnormal_mitochondrial_morpho1.79014941
21MP0005075_abnormal_melanosome_morpholog1.76320853
22MP0002148_abnormal_hypersensitivity_rea1.75444405
23MP0010094_abnormal_chromosome_stability1.73781758
24MP0002163_abnormal_gland_morphology1.72905815
25MP0002938_white_spotting1.69866734
26MP0004381_abnormal_hair_follicle1.68939898
27MP0002234_abnormal_pharynx_morphology1.68478734
28MP0002132_abnormal_respiratory_system1.68174592
29MP0003011_delayed_dark_adaptation1.66889474
30MP0003786_premature_aging1.66851965
31MP0004133_heterotaxia1.66282613
32MP0008058_abnormal_DNA_repair1.65861495
33MP0000372_irregular_coat_pigmentation1.56187695
34MP0002638_abnormal_pupillary_reflex1.54166286
35MP0009333_abnormal_splenocyte_physiolog1.51514531
36MP0000750_abnormal_muscle_regeneration1.50185537
37MP0005409_darkened_coat_color1.49565527
38MP0001346_abnormal_lacrimal_gland1.49442077
39MP0006292_abnormal_olfactory_placode1.48314813
40MP0004145_abnormal_muscle_electrophysio1.47478525
41MP0001727_abnormal_embryo_implantation1.45022587
42MP0003950_abnormal_plasma_membrane1.43749260
43MP0003718_maternal_effect1.43557816
44MP0005451_abnormal_body_composition1.38150439
45MP0003111_abnormal_nucleus_morphology1.35725310
46MP0003880_abnormal_central_pattern1.34718096
47MP0005330_cardiomyopathy1.33235647
48MP0003122_maternal_imprinting1.31295946
49MP0002822_catalepsy1.30165091
50MP0001853_heart_inflammation1.28591484
51MP0000049_abnormal_middle_ear1.28258313
52MP0003123_paternal_imprinting1.27367354
53MP0003567_abnormal_fetal_cardiomyocyte1.27155145
54MP0003941_abnormal_skin_development1.25441883
55MP0006072_abnormal_retinal_apoptosis1.24490198
56MP0002751_abnormal_autonomic_nervous1.24334676
57MP0000631_abnormal_neuroendocrine_gland1.23282293
58MP0005379_endocrine/exocrine_gland_phen1.22998120
59MP0001835_abnormal_antigen_presentation1.21001057
60MP0002095_abnormal_skin_pigmentation1.14005054
61MP0005408_hypopigmentation1.13712319
62MP0009785_altered_susceptibility_to1.11873732
63MP0004142_abnormal_muscle_tone1.11248945
64MP0003121_genomic_imprinting1.09574230
65MP0008007_abnormal_cellular_replicative1.08624363
66MP0008789_abnormal_olfactory_epithelium1.08610600
67MP0006276_abnormal_autonomic_nervous1.07331650
68MP0001485_abnormal_pinna_reflex1.06371637
69MP0002277_abnormal_respiratory_mucosa1.05819673
70MP0005671_abnormal_response_to1.05499297
71MP0000358_abnormal_cell_content/1.05049326
72MP0003315_abnormal_perineum_morphology1.04173926
73MP0002210_abnormal_sex_determination1.03256998
74MP0002736_abnormal_nociception_after1.02825390
75MP0001986_abnormal_taste_sensitivity1.02648081
76MP0005645_abnormal_hypothalamus_physiol1.02060007
77MP0005266_abnormal_metabolism1.02019790
78MP0003283_abnormal_digestive_organ0.99439362
79MP0001764_abnormal_homeostasis0.96783424
80MP0000685_abnormal_immune_system0.96415840
81MP0000026_abnormal_inner_ear0.95886764
82MP0005377_hearing/vestibular/ear_phenot0.95177483
83MP0003878_abnormal_ear_physiology0.95177483
84MP0003763_abnormal_thymus_physiology0.94540424
85MP0002249_abnormal_larynx_morphology0.93237391
86MP0002127_abnormal_cardiovascular_syste0.92862575
87MP0002102_abnormal_ear_morphology0.92169452
88MP0000678_abnormal_parathyroid_gland0.91357801
89MP0005171_absent_coat_pigmentation0.91242150
90MP0004084_abnormal_cardiac_muscle0.91085629
91MP0001286_abnormal_eye_development0.90919631
92MP0000313_abnormal_cell_death0.90409905
93MP0000490_abnormal_crypts_of0.89703699
94MP0005174_abnormal_tail_pigmentation0.89476673
95MP0003787_abnormal_imprinting0.88587312
96MP0005000_abnormal_immune_tolerance0.88199283
97MP0000920_abnormal_myelination0.87878480
98MP0001145_abnormal_male_reproductive0.87454275
99MP0005025_abnormal_response_to0.86888157
100MP0002697_abnormal_eye_size0.86430572
101MP0000762_abnormal_tongue_morphology0.85620977
102MP0002160_abnormal_reproductive_system0.83696471
103MP0001730_embryonic_growth_arrest0.83570211
104MP0003938_abnormal_ear_development0.80845022
105MP0008877_abnormal_DNA_methylation0.80577647
106MP0005646_abnormal_pituitary_gland0.80540311
107MP0000653_abnormal_sex_gland0.80390225
108MP0005084_abnormal_gallbladder_morpholo0.80355110
109MP0003646_muscle_fatigue0.80243342
110MP0004147_increased_porphyrin_level0.80121619
111MP0002722_abnormal_immune_system0.78725239
112MP0002106_abnormal_muscle_physiology0.77487588
113MP0002233_abnormal_nose_morphology0.76639906
114MP0005253_abnormal_eye_physiology0.76317636
115MP0001929_abnormal_gametogenesis0.75610725
116MP0005551_abnormal_eye_electrophysiolog0.75489270
117MP0001293_anophthalmia0.74480068
118MP0002752_abnormal_somatic_nervous0.74435404
119MP0002332_abnormal_exercise_endurance0.74108986
120MP0000566_synostosis0.73950414
121MP0009697_abnormal_copulation0.73287675
122MP0002405_respiratory_system_inflammati0.72889757
123MP0004215_abnormal_myocardial_fiber0.72816723
124MP0001968_abnormal_touch/_nociception0.71997522
125MP0006082_CNS_inflammation0.71230423
126MP0000689_abnormal_spleen_morphology0.71217291
127MP0002723_abnormal_immune_serum0.71074175
128MP0004036_abnormal_muscle_relaxation0.71032332
129MP0005391_vision/eye_phenotype0.70970677
130MP0000858_altered_metastatic_potential0.70349395
131MP0000613_abnormal_salivary_gland0.69814423
132MP0003137_abnormal_impulse_conducting0.69413518
133MP0003698_abnormal_male_reproductive0.69082949
134MP0005501_abnormal_skin_physiology0.68963479
135MP0000343_altered_response_to0.68355065
136MP0005195_abnormal_posterior_eye0.68342021
137MP0002019_abnormal_tumor_incidence0.67747656
138MP0001697_abnormal_embryo_size0.67111146
139MP0008872_abnormal_physiological_respon0.66964456
140MP0000778_abnormal_nervous_system0.66591162
141MP0001800_abnormal_humoral_immune0.66319730
142MP0002429_abnormal_blood_cell0.66210465
143MP0003937_abnormal_limbs/digits/tail_de0.65843856
144MP0000350_abnormal_cell_proliferation0.65759416
145MP0002420_abnormal_adaptive_immunity0.65532215
146MP0004742_abnormal_vestibular_system0.64525267
147MP0002557_abnormal_social/conspecific_i0.63365057
148MP0001963_abnormal_hearing_physiology0.62947560
149MP0002111_abnormal_tail_morphology0.61665296
150MP0002282_abnormal_trachea_morphology0.61319155
151MP0008875_abnormal_xenobiotic_pharmacok0.61072644

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)7.29798076
2Acute necrotizing encephalopathy (HP:0006965)5.98953774
3Abnormal number of erythroid precursors (HP:0012131)5.90145149
4Abnormal mitochondria in muscle tissue (HP:0008316)5.36968900
5Mitochondrial inheritance (HP:0001427)5.31757019
6Reticulocytopenia (HP:0001896)5.21111771
7Acute encephalopathy (HP:0006846)4.86602675
8Progressive macrocephaly (HP:0004481)4.71428766
9Macrocytic anemia (HP:0001972)4.65578991
10Hepatocellular necrosis (HP:0001404)4.57148605
11Increased CSF lactate (HP:0002490)4.52494431
12Decreased activity of mitochondrial respiratory chain (HP:0008972)4.46917044
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.46917044
14Increased hepatocellular lipid droplets (HP:0006565)4.46519702
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.30113213
16Hepatic necrosis (HP:0002605)4.19518479
17Pallor (HP:0000980)4.17709825
18Renal Fanconi syndrome (HP:0001994)4.15253092
19Lipid accumulation in hepatocytes (HP:0006561)4.08782992
20Microvesicular hepatic steatosis (HP:0001414)4.05709340
213-Methylglutaconic aciduria (HP:0003535)3.96135880
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.94389017
23Cerebral edema (HP:0002181)3.72755351
24Exercise intolerance (HP:0003546)3.72333232
25Increased intramyocellular lipid droplets (HP:0012240)3.62445330
26Aplasia/Hypoplasia of the sacrum (HP:0008517)3.61252461
27Exertional dyspnea (HP:0002875)3.58758456
28Increased serum pyruvate (HP:0003542)3.51290395
29Abnormality of glycolysis (HP:0004366)3.51290395
30Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.39022668
31Respiratory failure (HP:0002878)3.36195870
32Increased serum lactate (HP:0002151)3.30604482
33Leukodystrophy (HP:0002415)3.25986358
34Abnormal hemoglobin (HP:0011902)3.24675024
35Lactic acidosis (HP:0003128)3.23273400
36Increased muscle lipid content (HP:0009058)3.12158604
37Stenosis of the external auditory canal (HP:0000402)3.00278409
38Optic disc pallor (HP:0000543)2.94777102
39Parakeratosis (HP:0001036)2.84035985
40Cerebral hypomyelination (HP:0006808)2.73885948
41Respiratory difficulties (HP:0002880)2.61506918
42Congenital ichthyosiform erythroderma (HP:0007431)2.52712462
43Septo-optic dysplasia (HP:0100842)2.50158235
44Abnormality of renal resorption (HP:0011038)2.46346139
45Type I transferrin isoform profile (HP:0003642)2.37850710
46Pancreatic fibrosis (HP:0100732)2.28226574
47Sclerocornea (HP:0000647)2.22983835
48Hyperglycinemia (HP:0002154)2.19788874
49Aplastic anemia (HP:0001915)2.18751709
50Hyperphosphaturia (HP:0003109)2.16953606
51Myokymia (HP:0002411)2.16684657
52Abnormality of placental membranes (HP:0011409)2.15844765
53Amniotic constriction ring (HP:0009775)2.15844765
54Absent thumb (HP:0009777)2.10335393
55Pancreatic cysts (HP:0001737)2.04188630
56Multiple enchondromatosis (HP:0005701)2.00819419
57Rib fusion (HP:0000902)2.00396855
58Glycosuria (HP:0003076)2.00027527
59Abnormality of urine glucose concentration (HP:0011016)2.00027527
60True hermaphroditism (HP:0010459)1.99612404
61CNS demyelination (HP:0007305)1.98091774
62Maternal diabetes (HP:0009800)1.97550233
63Partial duplication of the phalanx of hand (HP:0009999)1.96359871
64Depressed nasal ridge (HP:0000457)1.93932806
65Trismus (HP:0000211)1.92936446
66Molar tooth sign on MRI (HP:0002419)1.92395356
67Abnormality of midbrain morphology (HP:0002418)1.92395356
68Breast hypoplasia (HP:0003187)1.90076889
69Absent septum pellucidum (HP:0001331)1.87737539
70Poor head control (HP:0002421)1.85770289
71Abnormal urine phosphate concentration (HP:0012599)1.85723983
72Abnormality of the anterior horn cell (HP:0006802)1.84593408
73Degeneration of anterior horn cells (HP:0002398)1.84593408
74Birth length less than 3rd percentile (HP:0003561)1.84032129
75Progressive muscle weakness (HP:0003323)1.83703142
76Emotional lability (HP:0000712)1.83279525
7711 pairs of ribs (HP:0000878)1.82835750
78Dicarboxylic aciduria (HP:0003215)1.82199630
79Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82199630
80Aplasia/hypoplasia of the uterus (HP:0008684)1.80599459
81Congenital, generalized hypertrichosis (HP:0004540)1.80102791
82Abnormality of the labia minora (HP:0012880)1.80019297
83Muscle fiber atrophy (HP:0100295)1.78971397
84Type 2 muscle fiber atrophy (HP:0003554)1.78885243
85Lethargy (HP:0001254)1.77345577
86Abnormality of the axillary hair (HP:0100134)1.77124067
87Abnormality of secondary sexual hair (HP:0009888)1.77124067
88Rough bone trabeculation (HP:0100670)1.74026967
89Methylmalonic aciduria (HP:0012120)1.71898815
90Hypoplasia of the radius (HP:0002984)1.70883546
91Oral leukoplakia (HP:0002745)1.70004863
92Asplenia (HP:0001746)1.69495341
93Generalized aminoaciduria (HP:0002909)1.69371033
94Medial flaring of the eyebrow (HP:0010747)1.68693401
95Rhabdomyolysis (HP:0003201)1.68555663
96Hyperglycinuria (HP:0003108)1.68147528
97Testicular atrophy (HP:0000029)1.67438523
98Partial duplication of thumb phalanx (HP:0009944)1.66285184
99Mesangial abnormality (HP:0001966)1.66231110
100Anophthalmia (HP:0000528)1.65341308
101Concave nail (HP:0001598)1.62657693
102X-linked dominant inheritance (HP:0001423)1.62324186
103Nephronophthisis (HP:0000090)1.59799384
104Aplasia/Hypoplasia of the uvula (HP:0010293)1.59224375
105Meckel diverticulum (HP:0002245)1.58911852
106Renal tubular dysfunction (HP:0000124)1.58902975
107Pancytopenia (HP:0001876)1.58481902
108Anencephaly (HP:0002323)1.56946217
109Blindness (HP:0000618)1.56115511
110Triphalangeal thumb (HP:0001199)1.55374652
111Abnormality of the ileum (HP:0001549)1.54473726
112Horseshoe kidney (HP:0000085)1.54373928
113Duplication of thumb phalanx (HP:0009942)1.53106120
114Gout (HP:0001997)1.53040010
115Abnormality of reticulocytes (HP:0004312)1.52521621
116Premature graying of hair (HP:0002216)1.51474874
117Methylmalonic acidemia (HP:0002912)1.50448803
118Carpal bone hypoplasia (HP:0001498)1.50259590
119Aplasia/Hypoplasia of the spleen (HP:0010451)1.50014536
120Aplasia/Hypoplasia involving the musculature (HP:0001460)1.49758328
121Increased IgM level (HP:0003496)1.49204128
122Reduced antithrombin III activity (HP:0001976)1.47968217
123Palpitations (HP:0001962)1.47649371
124Petechiae (HP:0000967)1.47473444
125Colon cancer (HP:0003003)1.47325980
126Cleft eyelid (HP:0000625)1.46768406
127Hypoplastic heart (HP:0001961)1.46709511
128Abnormal lung lobation (HP:0002101)1.44968210
129Abnormal glycosylation (HP:0012345)1.44501375
130Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.44501375
131Abnormal protein N-linked glycosylation (HP:0012347)1.44501375
132Abnormal protein glycosylation (HP:0012346)1.44501375

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK27.60464181
2NME25.23473294
3BUB15.06982855
4EIF2AK12.81812899
5TAF12.61155589
6MST42.58143693
7PIM22.56540307
8EIF2AK32.55371386
9PBK2.48809166
10STK162.46150795
11VRK12.40611683
12TESK22.25624882
13WEE12.15025791
14RPS6KB22.01255220
15NUAK11.99974485
16NME11.89888950
17MYLK1.65172218
18TLK11.60437389
19ILK1.57508821
20SRPK11.55547881
21BCKDK1.36790205
22EPHB21.36246007
23NEK11.35368984
24LIMK11.34257354
25PLK41.33159398
26ARAF1.30178315
27MKNK11.24829649
28STK391.24207192
29MUSK1.23947566
30CDK191.21599719
31KDR1.21440873
32MAPK151.20718692
33PASK1.20243166
34SMG11.14310601
35DYRK21.11708720
36PLK31.11669324
37ACVR1B1.11469082
38UHMK11.11399074
39MAP4K21.10828694
40ADRBK21.10470329
41CHEK21.08704754
42LRRK21.06844711
43BCR1.06067831
44GRK71.03273007
45ABL21.01443979
46OBSCN1.00291965
47TESK10.99707495
48CDK70.99355477
49MAPKAPK50.99044333
50ATR0.97628837
51AURKA0.91844737
52RPS6KA50.91827533
53BRSK20.89454629
54CDC70.88757325
55PAK10.87592965
56IRAK40.86637855
57WNK30.86104103
58AURKB0.84994691
59MAPKAPK30.82519153
60EIF2AK20.81465770
61TGFBR10.81124110
62IRAK30.80716286
63BLK0.79891229
64MAP3K110.78440265
65BMPR1B0.77540474
66STK40.74323918
67DAPK10.74186869
68PLK10.73029530
69CSNK2A10.72896862
70DYRK30.71426710
71BRSK10.71370218
72NEK20.70259560
73CDK80.70151807
74MAP2K70.69697947
75IKBKB0.69617085
76CSNK1G10.67968803
77CSNK2A20.65652717
78OXSR10.65230530
79BRAF0.63234258
80DAPK30.61473629
81MAP4K10.60297400
82RPS6KA60.59134072
83WNK40.58523155
84RPS6KL10.57872070
85RPS6KC10.57872070
86PAK40.57509742
87CLK10.56319598
88CSNK1G20.56059457
89EPHA40.55885214
90ROCK20.54687484
91PDK20.52068200
92MAP3K30.50317279
93STK240.48929225
94PHKG20.47661234
95PHKG10.47661234
96BTK0.47097437
97RPS6KA40.46750723
98MAP3K120.46382326
99CSNK1A1L0.46361402
100CSNK1G30.45298822
101TEC0.45073546
102TNIK0.44836736
103YES10.44557058
104GRK60.44236008
105PINK10.44101776
106LYN0.43611183
107PRKCG0.43031823
108CCNB10.43019893
109PIM10.42878656
110FLT30.42527999
111MAPKAPK20.41757271
112ADRBK10.41473439
113IRAK20.41458809
114PIK3CG0.41390600
115DYRK1B0.41332110
116PRKCI0.40862397
117GRK50.40452918
118INSRR0.40423819
119NLK0.39900064
120CDK11A0.39844149
121GRK10.39378103
122PRKCD0.39168945
123MAP2K20.38719958
124MKNK20.37661446
125CSNK1A10.37563363
126IRAK10.37461616
127ZAK0.36996592
128CHEK10.36116840
129TTK0.35516559
130TIE10.32749849
131CDK20.29177190
132AKT20.28176915
133CDK30.28098838
134CDK150.28067139
135CAMK10.27837569
136PRKACA0.27788721
137MAP3K40.27633689
138CSNK1E0.27103607
139CDK140.26230177

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.65520457
2* Oxidative phosphorylation_Homo sapiens_hsa001904.41421172
3Proteasome_Homo sapiens_hsa030504.27239266
4Parkinsons disease_Homo sapiens_hsa050123.93266135
5RNA polymerase_Homo sapiens_hsa030203.47224516
6Protein export_Homo sapiens_hsa030602.87576357
7Huntingtons disease_Homo sapiens_hsa050162.80655525
8DNA replication_Homo sapiens_hsa030302.79176309
9Alzheimers disease_Homo sapiens_hsa050102.72500298
10Mismatch repair_Homo sapiens_hsa034302.59136703
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.51401532
12Spliceosome_Homo sapiens_hsa030402.21711703
13Pyrimidine metabolism_Homo sapiens_hsa002402.12560024
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98207043
15Homologous recombination_Homo sapiens_hsa034401.94061877
16Nucleotide excision repair_Homo sapiens_hsa034201.87480503
17Base excision repair_Homo sapiens_hsa034101.68977704
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.66356126
19Cardiac muscle contraction_Homo sapiens_hsa042601.66329040
20Fatty acid elongation_Homo sapiens_hsa000621.53742880
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46726915
22RNA transport_Homo sapiens_hsa030131.31782703
23Basal transcription factors_Homo sapiens_hsa030221.20852070
24RNA degradation_Homo sapiens_hsa030181.20777693
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18414066
26Folate biosynthesis_Homo sapiens_hsa007901.12888313
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11591932
28Purine metabolism_Homo sapiens_hsa002301.06947475
29Non-homologous end-joining_Homo sapiens_hsa034501.06842616
30Glutathione metabolism_Homo sapiens_hsa004801.02214672
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00230824
32One carbon pool by folate_Homo sapiens_hsa006700.98580598
33Steroid biosynthesis_Homo sapiens_hsa001000.95682449
34Fanconi anemia pathway_Homo sapiens_hsa034600.93980548
35Sulfur metabolism_Homo sapiens_hsa009200.85804793
36Cell cycle_Homo sapiens_hsa041100.80705068
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79365092
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75339792
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74699107
40Arachidonic acid metabolism_Homo sapiens_hsa005900.74618632
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73583288
42* Metabolic pathways_Homo sapiens_hsa011000.72636401
43Butanoate metabolism_Homo sapiens_hsa006500.72119170
44Basal cell carcinoma_Homo sapiens_hsa052170.65031510
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63829710
46Epstein-Barr virus infection_Homo sapiens_hsa051690.63588521
47Arginine and proline metabolism_Homo sapiens_hsa003300.61627573
48Phenylalanine metabolism_Homo sapiens_hsa003600.60917694
49Sulfur relay system_Homo sapiens_hsa041220.59826377
50Allograft rejection_Homo sapiens_hsa053300.57733578
51Graft-versus-host disease_Homo sapiens_hsa053320.55195381
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53976063
53Linoleic acid metabolism_Homo sapiens_hsa005910.53734067
54Tyrosine metabolism_Homo sapiens_hsa003500.53399651
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52980079
56Carbon metabolism_Homo sapiens_hsa012000.48243763
57Vibrio cholerae infection_Homo sapiens_hsa051100.47488803
58Biosynthesis of amino acids_Homo sapiens_hsa012300.46444059
59Sphingolipid metabolism_Homo sapiens_hsa006000.46153703
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45240352
61p53 signaling pathway_Homo sapiens_hsa041150.44574233
62Nitrogen metabolism_Homo sapiens_hsa009100.42326912
63Tryptophan metabolism_Homo sapiens_hsa003800.41767686
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41478174
65Ether lipid metabolism_Homo sapiens_hsa005650.41114853
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.41087303
67Asthma_Homo sapiens_hsa053100.40130457
68Primary immunodeficiency_Homo sapiens_hsa053400.39016486
69Selenocompound metabolism_Homo sapiens_hsa004500.38802280
70Systemic lupus erythematosus_Homo sapiens_hsa053220.38235712
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37222797
72Histidine metabolism_Homo sapiens_hsa003400.36962034
73Pyruvate metabolism_Homo sapiens_hsa006200.35169609
74Peroxisome_Homo sapiens_hsa041460.34020953
75Pentose phosphate pathway_Homo sapiens_hsa000300.33659959
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33569165
77Autoimmune thyroid disease_Homo sapiens_hsa053200.32999873
78Phototransduction_Homo sapiens_hsa047440.32527544
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31978526
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31928069
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.31833874
82Propanoate metabolism_Homo sapiens_hsa006400.31708245
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31313423
84Fatty acid degradation_Homo sapiens_hsa000710.30943527
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.30055024
86Rheumatoid arthritis_Homo sapiens_hsa053230.29871552
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29314057
88beta-Alanine metabolism_Homo sapiens_hsa004100.28781994
89Chemical carcinogenesis_Homo sapiens_hsa052040.27429950
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.26882513
91Fatty acid metabolism_Homo sapiens_hsa012120.26349330
92Other glycan degradation_Homo sapiens_hsa005110.26058209
93Galactose metabolism_Homo sapiens_hsa000520.25568517
94mRNA surveillance pathway_Homo sapiens_hsa030150.25264765
95Collecting duct acid secretion_Homo sapiens_hsa049660.24529382
96Herpes simplex infection_Homo sapiens_hsa051680.22463642
97Phagosome_Homo sapiens_hsa041450.21004929
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.19615741
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19482066
100Fructose and mannose metabolism_Homo sapiens_hsa000510.18523958
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.18166208
102Vitamin digestion and absorption_Homo sapiens_hsa049770.17585786
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.16977522
104Fat digestion and absorption_Homo sapiens_hsa049750.16545922
105Legionellosis_Homo sapiens_hsa051340.16502553
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15308487
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.13737835
108Regulation of autophagy_Homo sapiens_hsa041400.13728841
109Retinol metabolism_Homo sapiens_hsa008300.12340789
110Caffeine metabolism_Homo sapiens_hsa002320.11892369
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.11713416
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.10728683
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10689899
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.10193873
115Hematopoietic cell lineage_Homo sapiens_hsa046400.09929735
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.09822585
117Vitamin B6 metabolism_Homo sapiens_hsa007500.08781654
118Viral myocarditis_Homo sapiens_hsa054160.08357980
119Shigellosis_Homo sapiens_hsa051310.08174102
120Antigen processing and presentation_Homo sapiens_hsa046120.06999391
121Hedgehog signaling pathway_Homo sapiens_hsa043400.06449717
122N-Glycan biosynthesis_Homo sapiens_hsa005100.05721312

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