ATP5F1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the b subunit of the proton channel. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.73344606
2* ATP synthesis coupled proton transport (GO:0015986)8.06823828
3* energy coupled proton transport, down electrochemical gradient (GO:0015985)8.06823828
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.10321722
5tricarboxylic acid cycle (GO:0006099)6.94023512
6* respiratory electron transport chain (GO:0022904)6.91703954
7* electron transport chain (GO:0022900)6.75152922
8oxidative phosphorylation (GO:0006119)6.41319780
9NADH metabolic process (GO:0006734)5.67983080
10mitochondrial respiratory chain complex I assembly (GO:0032981)5.06203764
11NADH dehydrogenase complex assembly (GO:0010257)5.06203764
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.06203764
13succinate metabolic process (GO:0006105)4.79186263
14protein complex biogenesis (GO:0070271)4.78558540
15* ATP biosynthetic process (GO:0006754)4.69254932
16mitochondrial respiratory chain complex assembly (GO:0033108)4.55223788
17cullin deneddylation (GO:0010388)4.51776207
18regulation of acyl-CoA biosynthetic process (GO:0050812)4.47562718
19regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.46146252
20chaperone-mediated protein transport (GO:0072321)4.43339789
21ribosomal large subunit biogenesis (GO:0042273)4.37099561
22aerobic respiration (GO:0009060)4.35463294
23inner mitochondrial membrane organization (GO:0007007)4.35170918
24oxaloacetate metabolic process (GO:0006107)4.33081806
25regulation of coenzyme metabolic process (GO:0051196)4.31101321
26regulation of cofactor metabolic process (GO:0051193)4.31101321
27establishment of integrated proviral latency (GO:0075713)4.30203151
28protein deneddylation (GO:0000338)4.25351731
29* purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.22839174
30* purine nucleoside triphosphate biosynthetic process (GO:0009145)4.22790175
31establishment of protein localization to mitochondrial membrane (GO:0090151)4.06803308
32* hydrogen ion transmembrane transport (GO:1902600)4.02137798
33quinone biosynthetic process (GO:1901663)3.94850576
34ubiquinone biosynthetic process (GO:0006744)3.94850576
35regulation of mitochondrial translation (GO:0070129)3.88724306
36formation of translation preinitiation complex (GO:0001731)3.82943555
37cellular respiration (GO:0045333)3.81908997
38* ribonucleoside triphosphate biosynthetic process (GO:0009201)3.79993080
39positive regulation of ligase activity (GO:0051351)3.74585700
40heart process (GO:0003015)3.74199223
41heart contraction (GO:0060047)3.74199223
42ribosome assembly (GO:0042255)3.67270061
43regulation of cellular amino acid metabolic process (GO:0006521)3.65659152
44* purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.63310578
45* purine nucleoside monophosphate biosynthetic process (GO:0009127)3.63310578
46L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.62836602
47SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.60817209
48ubiquinone metabolic process (GO:0006743)3.60051442
49cotranslational protein targeting to membrane (GO:0006613)3.57392611
50rRNA modification (GO:0000154)3.56964221
51translation (GO:0006412)3.56658623
52ribosomal small subunit assembly (GO:0000028)3.55151143
53negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.52241109
54protein targeting to ER (GO:0045047)3.51691200
55sarcomere organization (GO:0045214)3.51065594
56* proton transport (GO:0015992)3.50655864
57regulation of ubiquitin-protein transferase activity (GO:0051438)3.50205446
58protein neddylation (GO:0045116)3.49903067
59regulation of cellular respiration (GO:0043457)3.49310844
60* nucleoside triphosphate biosynthetic process (GO:0009142)3.46472456
61CENP-A containing nucleosome assembly (GO:0034080)3.45901967
62* hydrogen transport (GO:0006818)3.45061172
63proteasome assembly (GO:0043248)3.44545670
64establishment of viral latency (GO:0019043)3.43570998
65muscle filament sliding (GO:0030049)3.42415685
66actin-myosin filament sliding (GO:0033275)3.42415685
67establishment of protein localization to endoplasmic reticulum (GO:0072599)3.42227021
68* mitochondrial transport (GO:0006839)3.41546874
69regulation of ligase activity (GO:0051340)3.39467171
70respiratory chain complex IV assembly (GO:0008535)3.38671414
71protein localization to endoplasmic reticulum (GO:0070972)3.38531301
72chromatin remodeling at centromere (GO:0031055)3.35974299
73protein targeting to mitochondrion (GO:0006626)3.34941638
74maturation of SSU-rRNA (GO:0030490)3.34657724
75viral transcription (GO:0019083)3.34532765
76translational termination (GO:0006415)3.33197172
77DNA strand elongation involved in DNA replication (GO:0006271)3.32758952
78telomere maintenance via semi-conservative replication (GO:0032201)3.32198716
79establishment of protein localization to mitochondrion (GO:0072655)3.28830841
80lysine metabolic process (GO:0006553)3.28734009
81lysine catabolic process (GO:0006554)3.28734009
82positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.27062701
83termination of RNA polymerase III transcription (GO:0006386)3.26261468
84transcription elongation from RNA polymerase III promoter (GO:0006385)3.26261468
85protein localization to mitochondrion (GO:0070585)3.25044943
86regulation of sulfur metabolic process (GO:0042762)3.23097832
87spliceosomal snRNP assembly (GO:0000387)3.21623309
88translational initiation (GO:0006413)3.21250376
89DNA strand elongation (GO:0022616)3.18277265
90energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.18068218
91ATP hydrolysis coupled proton transport (GO:0015991)3.18068218
92negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.17884496
93negative regulation of ligase activity (GO:0051352)3.17884496
94nucleobase biosynthetic process (GO:0046112)3.17798487
95cytochrome complex assembly (GO:0017004)3.17180284
96branched-chain amino acid catabolic process (GO:0009083)3.15959710
97IMP biosynthetic process (GO:0006188)3.15753811
98L-methionine salvage (GO:0071267)3.14937218
99L-methionine biosynthetic process (GO:0071265)3.14937218
100amino acid salvage (GO:0043102)3.14937218
101regulation of oxidative phosphorylation (GO:0002082)3.14046644
102DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.13565960
103cellular component biogenesis (GO:0044085)3.13558041
104positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.13500916
105cellular ketone body metabolic process (GO:0046950)3.13072783
106DNA replication checkpoint (GO:0000076)3.12300299
107regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.11505799
108protein-cofactor linkage (GO:0018065)3.10604762
109tRNA aminoacylation (GO:0043039)3.10568797
110amino acid activation (GO:0043038)3.10568797
111* ribonucleoside monophosphate biosynthetic process (GO:0009156)3.10122101
112ribosomal small subunit biogenesis (GO:0042274)3.09908492
113tRNA aminoacylation for protein translation (GO:0006418)3.08646545
114aspartate family amino acid catabolic process (GO:0009068)3.07125511
115signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.07112481
116intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.07112481
117nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.06374412
118ribonucleoprotein complex biogenesis (GO:0022613)3.06338576
119peptidyl-histidine modification (GO:0018202)3.06311799
120exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.05799917
121translational elongation (GO:0006414)3.05545940
122maturation of 5.8S rRNA (GO:0000460)3.02757286
123pseudouridine synthesis (GO:0001522)3.02370033
124* purine ribonucleoside biosynthetic process (GO:0046129)3.02218516
125* purine nucleoside biosynthetic process (GO:0042451)3.02218516
126negative regulation of protein ubiquitination (GO:0031397)3.01505200
127rRNA processing (GO:0006364)3.01471407
128signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.00858511
129signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.00858511
130signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.00858511
1312-oxoglutarate metabolic process (GO:0006103)3.00334627
132anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.00156607
133* nucleoside monophosphate biosynthetic process (GO:0009124)2.96094541
134tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.95739772
135RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.95739772
136antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.95546223
137signal transduction involved in DNA damage checkpoint (GO:0072422)2.94169334
138signal transduction involved in DNA integrity checkpoint (GO:0072401)2.94169334
139cardiac myofibril assembly (GO:0055003)2.92899233
140signal transduction involved in cell cycle checkpoint (GO:0072395)2.90376078
141* generation of precursor metabolites and energy (GO:0006091)2.89433218
142positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.84848229
143gluconeogenesis (GO:0006094)2.83690364
144cardiac muscle contraction (GO:0060048)2.82025501
145regulation of cellular amine metabolic process (GO:0033238)2.79082808
146regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.78710940
147purine nucleobase biosynthetic process (GO:0009113)2.77712166

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.22058670
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.24876276
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.22604871
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.02160311
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.00664036
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.83445450
7* MYC_18555785_ChIP-Seq_MESCs_Mouse3.62752284
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.54311034
9ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.50361373
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.47495983
11* HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.31918841
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.24895842
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.15453488
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.95881845
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.94505481
16PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.86608451
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.83095387
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82219565
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.64972087
20DCP1A_22483619_ChIP-Seq_HELA_Human2.47600126
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.44196764
22* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.39301615
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.35344922
24VDR_23849224_ChIP-Seq_CD4+_Human2.30844732
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.30802235
26YY1_21170310_ChIP-Seq_MESCs_Mouse2.25089661
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10437144
28ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.09875705
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09445460
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.04952525
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.03888453
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98254545
33XRN2_22483619_ChIP-Seq_HELA_Human1.96943687
34GABP_19822575_ChIP-Seq_HepG2_Human1.95942096
35FOXP3_21729870_ChIP-Seq_TREG_Human1.92053768
36TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84530089
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.80027956
38ELK1_19687146_ChIP-ChIP_HELA_Human1.70761147
39HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.70595644
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.69966387
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69781351
42BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.69287217
43TTF2_22483619_ChIP-Seq_HELA_Human1.62753297
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.62139949
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.60947581
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59078405
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54760751
48CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.54714521
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.53833052
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52893714
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48557069
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.45479417
53CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43499343
54* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40024939
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38821963
56E2F7_22180533_ChIP-Seq_HELA_Human1.36537179
57AR_21909140_ChIP-Seq_LNCAP_Human1.35886034
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32682022
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31762243
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24590233
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22699321
62VDR_22108803_ChIP-Seq_LS180_Human1.17639870
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.15742239
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12545393
65EWS_26573619_Chip-Seq_HEK293_Human1.09419454
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08399921
67GATA4_21415370_ChIP-Seq_HL-1_Mouse1.07972640
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07820558
69MYC_18940864_ChIP-ChIP_HL60_Human1.07428395
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06862086
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05675207
72FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02910128
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02886596
74FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02326056
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02042906
76TFEB_21752829_ChIP-Seq_HELA_Human1.01722745
77NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00295901
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96497386
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96363583
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95177789
81TAF15_26573619_Chip-Seq_HEK293_Human0.94043480
82SOX17_20123909_ChIP-Seq_XEN_Mouse0.93552895
83SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92605222
84MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.91653631
85* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90980692
86KDM5A_27292631_Chip-Seq_BREAST_Human0.90302467
87TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89792139
88SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89595901
89* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88704032
90* NANOG_16153702_ChIP-ChIP_HESCs_Human0.87410313
91SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.84505670
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84342986
93ELF5_23300383_ChIP-Seq_T47D_Human0.81663896
94POU3F2_20337985_ChIP-ChIP_501MEL_Human0.81492838
95HTT_18923047_ChIP-ChIP_STHdh_Human0.80748695
96CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.78504517
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.78182055
98IGF1R_20145208_ChIP-Seq_DFB_Human0.78068814
99SALL1_21062744_ChIP-ChIP_HESCs_Human0.76684027
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.76589708
101REST_19997604_ChIP-ChIP_NEURONS_Mouse0.75454614
102TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.75053941
103CIITA_25753668_ChIP-Seq_RAJI_Human0.74067190
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.71465585
105OCT4_18692474_ChIP-Seq_MEFs_Mouse0.71241938
106CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.71215484
107SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.71196228
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.70486636
109FUS_26573619_Chip-Seq_HEK293_Human0.70486142
110PPARA_22158963_ChIP-Seq_LIVER_Mouse0.69917541
111SALL4_22934838_ChIP-ChIP_CD34+_Human0.69877353
112EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.69864449
113FLI1_27457419_Chip-Seq_LIVER_Mouse0.69317023
114ZNF263_19887448_ChIP-Seq_K562_Human0.68943919
115MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.68492568
116PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.67549904
117RXR_22158963_ChIP-Seq_LIVER_Mouse0.67180557
118EGR1_23403033_ChIP-Seq_LIVER_Mouse0.66995368
119* SOX2_16153702_ChIP-ChIP_HESCs_Human0.66898965
120ZNF274_21170338_ChIP-Seq_K562_Hela0.66487061
121NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.64504577

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.34767687
2MP0008058_abnormal_DNA_repair4.37198331
3MP0003646_muscle_fatigue4.35947550
4MP0004084_abnormal_cardiac_muscle3.96193897
5MP0006036_abnormal_mitochondrial_physio3.91648089
6MP0004215_abnormal_myocardial_fiber3.72822602
7MP0003806_abnormal_nucleotide_metabolis3.72718490
8MP0000751_myopathy3.47973978
9MP0004036_abnormal_muscle_relaxation3.22124154
10MP0000749_muscle_degeneration3.07161522
11MP0006035_abnormal_mitochondrial_morpho2.93090878
12MP0003077_abnormal_cell_cycle2.89811962
13MP0003111_abnormal_nucleus_morphology2.89480830
14MP0005330_cardiomyopathy2.79452775
15MP0001529_abnormal_vocalization2.67753127
16MP0003786_premature_aging2.58499357
17MP0008007_abnormal_cellular_replicative2.38594592
18MP0002972_abnormal_cardiac_muscle2.20487990
19MP0003221_abnormal_cardiomyocyte_apopto2.20291558
20MP0004043_abnormal_pH_regulation2.14194056
21MP0008775_abnormal_heart_ventricle1.98570288
22MP0004147_increased_porphyrin_level1.96739517
23MP0005620_abnormal_muscle_contractility1.95634131
24MP0003137_abnormal_impulse_conducting1.91550031
25MP0005360_urolithiasis1.91065957
26MP0003186_abnormal_redox_activity1.86481138
27MP0005385_cardiovascular_system_phenoty1.79901622
28MP0001544_abnormal_cardiovascular_syste1.79901622
29MP0005332_abnormal_amino_acid1.78164485
30MP0008057_abnormal_DNA_replication1.77154586
31MP0006072_abnormal_retinal_apoptosis1.77079686
32MP0002102_abnormal_ear_morphology1.75059811
33MP0003941_abnormal_skin_development1.74782810
34MP0002938_white_spotting1.71904155
35MP0005085_abnormal_gallbladder_physiolo1.71511652
36MP0004484_altered_response_of1.71418303
37MP0002269_muscular_atrophy1.70186511
38MP0004087_abnormal_muscle_fiber1.68027026
39MP0002106_abnormal_muscle_physiology1.65289588
40MP0003880_abnormal_central_pattern1.63004554
41MP0004145_abnormal_muscle_electrophysio1.62054729
42MP0005266_abnormal_metabolism1.61725438
43MP0003195_calcinosis1.60766220
44MP0008875_abnormal_xenobiotic_pharmacok1.58794054
45MP0006138_congestive_heart_failure1.58713396
46MP0005408_hypopigmentation1.55070013
47MP0002332_abnormal_exercise_endurance1.54386140
48MP0002139_abnormal_hepatobiliary_system1.54064825
49MP0000750_abnormal_muscle_regeneration1.51986980
50MP0000747_muscle_weakness1.51332958
51MP0004085_abnormal_heartbeat1.50796224
52MP0004957_abnormal_blastocyst_morpholog1.43935080
53MP0001905_abnormal_dopamine_level1.42725586
54MP0006276_abnormal_autonomic_nervous1.42072094
55MP0003123_paternal_imprinting1.41148205
56MP0003122_maternal_imprinting1.39226923
57MP0001764_abnormal_homeostasis1.37313985
58MP0009697_abnormal_copulation1.36625712
59MP0004130_abnormal_muscle_cell1.34275032
60MP0002090_abnormal_vision1.33264547
61MP0004233_abnormal_muscle_weight1.32189462
62MP0004142_abnormal_muscle_tone1.30946246
63MP0005369_muscle_phenotype1.27432580
64MP0001730_embryonic_growth_arrest1.25950985
65MP0008789_abnormal_olfactory_epithelium1.23591375
66MP0002876_abnormal_thyroid_physiology1.21365245
67MP0003950_abnormal_plasma_membrane1.21206983
68MP0002127_abnormal_cardiovascular_syste1.19282281
69MP0002822_catalepsy1.19208449
70MP0008995_early_reproductive_senescence1.19065518
71MP0000350_abnormal_cell_proliferation1.14230132
72MP0003656_abnormal_erythrocyte_physiolo1.10925953
73MP0003693_abnormal_embryo_hatching1.10454342
74MP0002638_abnormal_pupillary_reflex1.10325407
75MP0005636_abnormal_mineral_homeostasis1.10182736
76MP0005584_abnormal_enzyme/coenzyme_acti1.09960922
77MP0000759_abnormal_skeletal_muscle1.09739356
78MP0001697_abnormal_embryo_size1.08128482
79MP0010630_abnormal_cardiac_muscle1.06896991
80MP0002163_abnormal_gland_morphology1.06014468
81MP0005365_abnormal_bile_salt1.04799686
82MP0009379_abnormal_foot_pigmentation1.04657068
83MP0005451_abnormal_body_composition1.03296226
84MP0000230_abnormal_systemic_arterial1.01033130
85MP0005376_homeostasis/metabolism_phenot1.00966142
86MP0005253_abnormal_eye_physiology1.00935889
87MP0003567_abnormal_fetal_cardiomyocyte1.00840994
88MP0005075_abnormal_melanosome_morpholog1.00392988
89MP0002736_abnormal_nociception_after0.99852119
90MP0002160_abnormal_reproductive_system0.99385572
91MP0000358_abnormal_cell_content/0.98788631
92MP0001929_abnormal_gametogenesis0.98250873
93MP0005319_abnormal_enzyme/_coenzyme0.97631645
94MP0002210_abnormal_sex_determination0.96825341
95MP0005386_behavior/neurological_phenoty0.95946913
96MP0004924_abnormal_behavior0.95946913
97MP0000313_abnormal_cell_death0.95931759
98MP0002095_abnormal_skin_pigmentation0.92434718
99MP0003011_delayed_dark_adaptation0.89737684
100MP0002080_prenatal_lethality0.89477504
101MP0000013_abnormal_adipose_tissue0.89300196
102MP0005535_abnormal_body_temperature0.88853711
103MP0002735_abnormal_chemical_nociception0.87172689
104MP0000647_abnormal_sebaceous_gland0.86812912
105MP0001984_abnormal_olfaction0.86705243
106MP0002272_abnormal_nervous_system0.86695638
107MP0009046_muscle_twitch0.86659747
108MP0003136_yellow_coat_color0.85842870
109MP0001727_abnormal_embryo_implantation0.83594942
110MP0003315_abnormal_perineum_morphology0.83189719
111MP0003718_maternal_effect0.80667335
112MP0005083_abnormal_biliary_tract0.80128050
113MP0009745_abnormal_behavioral_response0.79746951
114MP0001672_abnormal_embryogenesis/_devel0.79329417
115MP0005380_embryogenesis_phenotype0.79329417
116MP0001293_anophthalmia0.79208513
117MP0001145_abnormal_male_reproductive0.78759621
118MP0000653_abnormal_sex_gland0.77928340
119MP0009643_abnormal_urine_homeostasis0.77875132
120MP0001661_extended_life_span0.77489331
121MP0002234_abnormal_pharynx_morphology0.76953048
122MP0008932_abnormal_embryonic_tissue0.76373955
123MP0005187_abnormal_penis_morphology0.75162559
124MP0005084_abnormal_gallbladder_morpholo0.74264256
125MP0000516_abnormal_urinary_system0.74052907
126MP0005367_renal/urinary_system_phenotyp0.74052907
127MP0002064_seizures0.73134613
128MP0010094_abnormal_chromosome_stability0.71513302
129MP0001440_abnormal_grooming_behavior0.70374705
130MP0001485_abnormal_pinna_reflex0.69909819
131MP0008872_abnormal_physiological_respon0.69657647
132MP0005379_endocrine/exocrine_gland_phen0.69116487
133MP0010307_abnormal_tumor_latency0.67557509
134MP0003984_embryonic_growth_retardation0.64850326
135MP0002088_abnormal_embryonic_growth/wei0.62379293
136MP0008877_abnormal_DNA_methylation0.62304393
137MP0000372_irregular_coat_pigmentation0.62196978
138MP0002084_abnormal_developmental_patter0.62050167
139MP0004270_analgesia0.61405454
140MP0002019_abnormal_tumor_incidence0.60958801
141MP0002078_abnormal_glucose_homeostasis0.60141300
142MP0001968_abnormal_touch/_nociception0.59849410
143MP0001756_abnormal_urination0.59309548
144MP0001853_heart_inflammation0.58909523
145MP0005165_increased_susceptibility_to0.57300390
146MP0010329_abnormal_lipoprotein_level0.57255282
147MP0005394_taste/olfaction_phenotype0.56974835
148MP0005499_abnormal_olfactory_system0.56974835
149MP0000343_altered_response_to0.55412298
150MP0002067_abnormal_sensory_capabilities0.54835746

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.85849743
2Abnormal mitochondria in muscle tissue (HP:0008316)6.59799860
3Acute encephalopathy (HP:0006846)6.00688155
4Mitochondrial inheritance (HP:0001427)5.84608645
5Progressive macrocephaly (HP:0004481)5.70424697
6Hepatocellular necrosis (HP:0001404)5.60062492
7Hepatic necrosis (HP:0002605)5.50381941
8Abnormality of glycolysis (HP:0004366)5.50269988
9Increased serum pyruvate (HP:0003542)5.50269988
10Increased CSF lactate (HP:0002490)5.48583928
11Cerebral edema (HP:0002181)4.83856083
12Lactic acidosis (HP:0003128)4.20880796
13Respiratory failure (HP:0002878)3.97368681
14Exercise intolerance (HP:0003546)3.96977395
15Increased serum lactate (HP:0002151)3.82055513
16Lipid accumulation in hepatocytes (HP:0006561)3.80524797
17Increased hepatocellular lipid droplets (HP:0006565)3.72694358
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.65019953
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.65019953
20Increased intramyocellular lipid droplets (HP:0012240)3.63284873
21Palpitations (HP:0001962)3.60014431
22Neuroendocrine neoplasm (HP:0100634)3.56966308
23Increased muscle lipid content (HP:0009058)3.54586222
24Pheochromocytoma (HP:0002666)3.52733959
25Exercise-induced muscle cramps (HP:0003710)3.50002938
26Sudden death (HP:0001699)3.36711363
27Abnormality of alanine metabolism (HP:0010916)3.33844379
28Hyperalaninemia (HP:0003348)3.33844379
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.33844379
30Leukodystrophy (HP:0002415)3.32856230
31Myoglobinuria (HP:0002913)3.31902868
32Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.24787059
33Calf muscle hypertrophy (HP:0008981)3.13734281
34Optic disc pallor (HP:0000543)3.08078003
35Rhabdomyolysis (HP:0003201)3.07288422
36Exercise-induced myalgia (HP:0003738)3.04565682
37Muscle hypertrophy of the lower extremities (HP:0008968)3.03367576
38Lethargy (HP:0001254)3.02424098
39Conjunctival hamartoma (HP:0100780)3.01983599
40CNS demyelination (HP:0007305)3.00790888
41Neoplasm of the adrenal gland (HP:0100631)2.94523860
42Ragged-red muscle fibers (HP:0003200)2.94200778
43Abnormality of dicarboxylic acid metabolism (HP:0010995)2.93985669
44Dicarboxylic aciduria (HP:0003215)2.93985669
45Macrocytic anemia (HP:0001972)2.88902146
46Type I transferrin isoform profile (HP:0003642)2.87174323
47Abnormality of fatty-acid metabolism (HP:0004359)2.79876911
48Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.76704134
49Renal Fanconi syndrome (HP:0001994)2.75191892
50Abnormality of methionine metabolism (HP:0010901)2.69794909
51Abnormality of the anterior horn cell (HP:0006802)2.60917505
52Degeneration of anterior horn cells (HP:0002398)2.60917505
53Aplastic anemia (HP:0001915)2.60767285
543-Methylglutaconic aciduria (HP:0003535)2.59341925
55Emotional lability (HP:0000712)2.55404078
56Generalized aminoaciduria (HP:0002909)2.54242765
57Glycosuria (HP:0003076)2.52820784
58Abnormality of urine glucose concentration (HP:0011016)2.52820784
59Ventricular tachycardia (HP:0004756)2.51509962
60Reticulocytopenia (HP:0001896)2.50943084
61Ketoacidosis (HP:0001993)2.48985885
62Respiratory difficulties (HP:0002880)2.43613049
63Methylmalonic aciduria (HP:0012120)2.42176041
64Reduced antithrombin III activity (HP:0001976)2.37343598
65Vomiting (HP:0002013)2.33884334
66Lipoatrophy (HP:0100578)2.32627679
67Abnormality of aspartate family amino acid metabolism (HP:0010899)2.31564870
68Abnormality of the calf musculature (HP:0001430)2.30973189
69Abnormal protein glycosylation (HP:0012346)2.30278814
70Abnormal glycosylation (HP:0012345)2.30278814
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.30278814
72Abnormal protein N-linked glycosylation (HP:0012347)2.30278814
73Amniotic constriction ring (HP:0009775)2.29499713
74Abnormality of placental membranes (HP:0011409)2.29499713
75Hyperammonemia (HP:0001987)2.25923824
76Muscle fiber splitting (HP:0003555)2.24086212
77Gliosis (HP:0002171)2.22868483
78Metabolic acidosis (HP:0001942)2.22207290
79X-linked dominant inheritance (HP:0001423)2.21210165
80Neoplasm of head and neck (HP:0012288)2.19732975
81Esophageal neoplasm (HP:0100751)2.19732975
82Exertional dyspnea (HP:0002875)2.16750584
83Atrial fibrillation (HP:0005110)2.16573425
84Hypoglycemic coma (HP:0001325)2.16186501
85Hyperglycinuria (HP:0003108)2.15453970
86Cerebral hypomyelination (HP:0006808)2.14167386
87Ketosis (HP:0001946)2.10875827
88Supraventricular tachycardia (HP:0004755)2.10837500
89Proximal tubulopathy (HP:0000114)2.06800085
90Dilated cardiomyopathy (HP:0001644)2.06386866
91Myotonia (HP:0002486)2.03538136
92Primary atrial arrhythmia (HP:0001692)2.02650595
93Supraventricular arrhythmia (HP:0005115)2.02264035
94Microvesicular hepatic steatosis (HP:0001414)2.02234178
95Abnormality of serine family amino acid metabolism (HP:0010894)1.99969460
96Abnormality of glycine metabolism (HP:0010895)1.99969460
97Megaloblastic anemia (HP:0001889)1.99616557
98Muscle stiffness (HP:0003552)1.98813466
99Rimmed vacuoles (HP:0003805)1.97585071
100Nemaline bodies (HP:0003798)1.96972545
101Abnormality of renal resorption (HP:0011038)1.96580122
102Renal cortical cysts (HP:0000803)1.95642504
103Pancytopenia (HP:0001876)1.95417663
104Nausea (HP:0002018)1.94975160
105Neoplasm of the peripheral nervous system (HP:0100007)1.93681087
106Gout (HP:0001997)1.92780392
107Abnormality of cells of the erythroid lineage (HP:0012130)1.90332465
108Syncope (HP:0001279)1.89971359
109Abnormal number of erythroid precursors (HP:0012131)1.88987422
110Hyperphosphaturia (HP:0003109)1.86230580
111Cholecystitis (HP:0001082)1.85998881
112Abnormal gallbladder physiology (HP:0012438)1.85998881
113Cerebral hemorrhage (HP:0001342)1.85959148
114Hypobetalipoproteinemia (HP:0003563)1.85533295
115Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.85385592
116Colon cancer (HP:0003003)1.84909604
117EMG: myopathic abnormalities (HP:0003458)1.84574760
118Abnormality of serum amino acid levels (HP:0003112)1.84077079
119Hyperglycinemia (HP:0002154)1.83457487
120Pallor (HP:0000980)1.82172948
121Abnormality of the preputium (HP:0100587)1.82147022
122Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82088275
123Meckel diverticulum (HP:0002245)1.82007069
124Tinnitus (HP:0000360)1.80673063
125Oral leukoplakia (HP:0002745)1.79172637
126Multiple enchondromatosis (HP:0005701)1.78541622
127Abnormality of the vitamin B12 metabolism (HP:0004341)1.78127363
128Abnormality of chromosome stability (HP:0003220)1.78087653
129Birth length less than 3rd percentile (HP:0003561)1.76485413
130Methylmalonic acidemia (HP:0002912)1.76149135
131Abnormality of vitamin B metabolism (HP:0004340)1.75747857
132Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.74159774
133Muscle fiber inclusion bodies (HP:0100299)1.73068450
134Type 2 muscle fiber atrophy (HP:0003554)1.73066768
135Abnormality of the ileum (HP:0001549)1.72263117
136Chromsome breakage (HP:0040012)1.71594906

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN3.55232286
2STK163.53562249
3NEK13.49074472
4BCKDK3.40564059
5MYLK3.38428721
6PDK33.27861063
7PDK43.27861063
8NME13.23644125
9VRK23.16367338
10MAP3K122.82643692
11EIF2AK12.62085240
12BUB12.48484885
13NME22.28718585
14TRIM282.03953742
15PDK21.94708042
16WEE11.91791788
17TSSK61.77240471
18ARAF1.68399002
19LIMK11.66509035
20PHKG21.63246628
21PHKG11.63246628
22LMTK21.61752837
23CCNB11.59310512
24EIF2AK31.58839432
25STK241.44424898
26WNK41.43342325
27ERBB31.40837672
28OXSR11.38050075
29MST41.32820055
30NUAK11.30842927
31MAP4K21.27760798
32TTN1.25763350
33GRK71.24831101
34WNK31.19012487
35VRK11.15629386
36CDK191.14783222
37BRAF1.11510627
38CASK1.08203829
39ILK1.08192054
40BRSK21.05708628
41PLK21.05050811
42CDK81.05020780
43STK38L1.04236540
44BCR1.03545537
45MUSK1.02937659
46MAP2K71.02713184
47PAK41.01853762
48PIK3CA0.98996336
49ZAK0.98976160
50STK390.97758375
51ACVR1B0.90217851
52CAMK2D0.87833453
53MAP3K40.87571404
54EIF2AK20.86681291
55SRPK10.86361008
56DAPK10.86360761
57CSNK1G20.83726225
58MAP2K40.81760306
59CSNK1G10.81384217
60ATR0.80731604
61TESK10.80113846
62MINK10.79880463
63TLK10.79802680
64PBK0.78317439
65CAMK2G0.77305896
66CSNK1A1L0.77163030
67PINK10.76865481
68CDC70.74890810
69DAPK30.72631737
70CHEK20.70181831
71PASK0.69508250
72PLK30.69468553
73TAF10.69353155
74ABL20.68325243
75BRSK10.67828315
76AURKA0.67065487
77CAMK2B0.66620865
78KDR0.66044086
79SCYL20.65082676
80MAPKAPK50.64020546
81CAMK2A0.62344600
82STK40.59528232
83TESK20.58877187
84BMPR1B0.56263300
85SIK30.56116014
86MKNK10.52005490
87RPS6KA40.51737318
88GRK50.51458508
89PLK10.51227452
90RPS6KB20.50832567
91FLT30.50807196
92PRKCG0.50704390
93ATM0.49560480
94AURKB0.48098901
95ADRBK20.47278424
96DYRK20.47252583
97MAP3K110.46943775
98CHEK10.46779993
99AKT30.46277243
100PRKACA0.45060776
101TIE10.45020559
102CSNK2A10.44846324
103PRKG20.44067096
104RPS6KA50.43089339
105ADRBK10.42862547
106NEK20.42454338
107ALK0.42066811
108PNCK0.41225089
109CSNK2A20.40321824
110GRK10.39131854
111TNIK0.39023438
112CDK180.38819619
113CSNK1E0.37396439
114PLK40.37295246
115CDK140.36357569
116BMPR20.36224608
117DYRK30.35653962
118PKN20.34433874
119PIM20.33753517
120AKT20.33732349
121PRKCI0.33697916
122MKNK20.33102758
123CDK70.32917680
124MST1R0.32799780
125TTK0.32772867
126MAPKAPK30.32582599
127ERBB40.32203312
128ROCK20.31356704
129CDK150.31295805
130CSNK1G30.30677052
131PRKACB0.30437252
132MAP2K60.30373644
133PAK10.29237199
134CLK10.28667063
135MAP3K50.27236366

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.02523169
2* Oxidative phosphorylation_Homo sapiens_hsa001904.96070959
3Parkinsons disease_Homo sapiens_hsa050124.42668814
4Proteasome_Homo sapiens_hsa030503.42065124
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.40476918
6Alzheimers disease_Homo sapiens_hsa050103.10028731
7Huntingtons disease_Homo sapiens_hsa050163.02135887
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.64761919
9Cardiac muscle contraction_Homo sapiens_hsa042602.61921525
10Propanoate metabolism_Homo sapiens_hsa006402.60469348
11Pyruvate metabolism_Homo sapiens_hsa006202.35691467
12Carbon metabolism_Homo sapiens_hsa012002.32621169
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.31272545
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.20078475
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.01066258
16Ribosome_Homo sapiens_hsa030101.96972548
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.88443603
18Fatty acid degradation_Homo sapiens_hsa000711.67120849
19Butanoate metabolism_Homo sapiens_hsa006501.66580803
20Fatty acid elongation_Homo sapiens_hsa000621.60917107
21RNA polymerase_Homo sapiens_hsa030201.57221606
22Biosynthesis of amino acids_Homo sapiens_hsa012301.52259955
23Collecting duct acid secretion_Homo sapiens_hsa049661.48014241
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47472247
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.43169098
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.36038469
27Fatty acid metabolism_Homo sapiens_hsa012121.34625342
28Fanconi anemia pathway_Homo sapiens_hsa034601.29803077
29DNA replication_Homo sapiens_hsa030301.21828540
30Protein export_Homo sapiens_hsa030601.19319286
31Pyrimidine metabolism_Homo sapiens_hsa002401.11980897
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09231396
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07874380
34Peroxisome_Homo sapiens_hsa041461.04617842
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04558044
36Mismatch repair_Homo sapiens_hsa034301.02741480
37Sulfur metabolism_Homo sapiens_hsa009201.01347340
38Phenylalanine metabolism_Homo sapiens_hsa003600.93020965
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92505652
40Vibrio cholerae infection_Homo sapiens_hsa051100.90936795
41* Metabolic pathways_Homo sapiens_hsa011000.89133169
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88727110
43beta-Alanine metabolism_Homo sapiens_hsa004100.88128264
44Glutathione metabolism_Homo sapiens_hsa004800.81230303
45Nucleotide excision repair_Homo sapiens_hsa034200.80647088
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79084166
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79064650
48Pentose phosphate pathway_Homo sapiens_hsa000300.78201800
49Steroid biosynthesis_Homo sapiens_hsa001000.76558327
50Fructose and mannose metabolism_Homo sapiens_hsa000510.75542022
51Tyrosine metabolism_Homo sapiens_hsa003500.74102496
52Tryptophan metabolism_Homo sapiens_hsa003800.72925338
53Folate biosynthesis_Homo sapiens_hsa007900.72349405
54Purine metabolism_Homo sapiens_hsa002300.70058475
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69761565
56Arginine and proline metabolism_Homo sapiens_hsa003300.69240892
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.67011977
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.63569450
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63042366
60Spliceosome_Homo sapiens_hsa030400.61710300
61Arginine biosynthesis_Homo sapiens_hsa002200.58377574
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58115952
63RNA transport_Homo sapiens_hsa030130.57696559
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.55024819
65Synaptic vesicle cycle_Homo sapiens_hsa047210.53411408
66Galactose metabolism_Homo sapiens_hsa000520.52225898
67Dilated cardiomyopathy_Homo sapiens_hsa054140.51128314
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48021189
69Homologous recombination_Homo sapiens_hsa034400.47841760
70Starch and sucrose metabolism_Homo sapiens_hsa005000.47791315
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44885086
72N-Glycan biosynthesis_Homo sapiens_hsa005100.44654376
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44475723
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44234329
75mRNA surveillance pathway_Homo sapiens_hsa030150.43779298
76Nitrogen metabolism_Homo sapiens_hsa009100.42409114
77One carbon pool by folate_Homo sapiens_hsa006700.42149484
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41039999
79Base excision repair_Homo sapiens_hsa034100.41031115
80PPAR signaling pathway_Homo sapiens_hsa033200.39159545
81RNA degradation_Homo sapiens_hsa030180.38128366
82p53 signaling pathway_Homo sapiens_hsa041150.37904241
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37613926
84Sulfur relay system_Homo sapiens_hsa041220.36265004
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34940206
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32891851
87Regulation of autophagy_Homo sapiens_hsa041400.31477967
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31213702
89Vitamin B6 metabolism_Homo sapiens_hsa007500.30894104
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30288073
91Chemical carcinogenesis_Homo sapiens_hsa052040.29069915
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.28921561
93Caffeine metabolism_Homo sapiens_hsa002320.26824032
94Basal transcription factors_Homo sapiens_hsa030220.26453109
95Retinol metabolism_Homo sapiens_hsa008300.26130370
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24879175
97Glucagon signaling pathway_Homo sapiens_hsa049220.23940744
98Histidine metabolism_Homo sapiens_hsa003400.23534308
99Systemic lupus erythematosus_Homo sapiens_hsa053220.23356670
100Epstein-Barr virus infection_Homo sapiens_hsa051690.22818679
101Nicotine addiction_Homo sapiens_hsa050330.21140983
102Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.19923348
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.19772229
104Fat digestion and absorption_Homo sapiens_hsa049750.19206901
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.19188642
106Selenocompound metabolism_Homo sapiens_hsa004500.19144120
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19054503
108Asthma_Homo sapiens_hsa053100.16743779
109Non-homologous end-joining_Homo sapiens_hsa034500.14013363
110Phagosome_Homo sapiens_hsa041450.10546864
111Oocyte meiosis_Homo sapiens_hsa041140.10264932
112Calcium signaling pathway_Homo sapiens_hsa040200.09951923
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.08888635
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.07803443
115Cell cycle_Homo sapiens_hsa041100.07629192
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.07169636
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.07056245
118Rheumatoid arthritis_Homo sapiens_hsa053230.04033485
119Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.03365067

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