ATP5C1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* mitochondrial ATP synthesis coupled proton transport (GO:0042776)9.50900458
2* energy coupled proton transport, down electrochemical gradient (GO:0015985)8.87314949
3* ATP synthesis coupled proton transport (GO:0015986)8.87314949
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.70912557
5* respiratory electron transport chain (GO:0022904)7.57554265
6* electron transport chain (GO:0022900)7.39648742
7tricarboxylic acid cycle (GO:0006099)7.29065706
8* oxidative phosphorylation (GO:0006119)6.46761069
9NADH metabolic process (GO:0006734)5.54256708
10regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.17547359
11regulation of acyl-CoA biosynthetic process (GO:0050812)5.15655311
12mitochondrial respiratory chain complex I assembly (GO:0032981)5.05069029
13NADH dehydrogenase complex assembly (GO:0010257)5.05069029
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.05069029
15* ATP biosynthetic process (GO:0006754)5.04469665
16regulation of cofactor metabolic process (GO:0051193)4.95675970
17regulation of coenzyme metabolic process (GO:0051196)4.95675970
18protein complex biogenesis (GO:0070271)4.86571204
19aerobic respiration (GO:0009060)4.66622352
20succinate metabolic process (GO:0006105)4.66184169
21mitochondrial respiratory chain complex assembly (GO:0033108)4.65778445
22inner mitochondrial membrane organization (GO:0007007)4.55501297
23heart contraction (GO:0060047)4.48424789
24heart process (GO:0003015)4.48424789
25* purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.48317265
26* purine nucleoside triphosphate biosynthetic process (GO:0009145)4.47308275
27sarcomere organization (GO:0045214)4.42747252
28cullin deneddylation (GO:0010388)4.33587387
29muscle filament sliding (GO:0030049)4.20845513
30actin-myosin filament sliding (GO:0033275)4.20845513
31regulation of mitochondrial translation (GO:0070129)4.17944189
32oxaloacetate metabolic process (GO:0006107)4.13767747
33establishment of protein localization to mitochondrial membrane (GO:0090151)4.11273731
34ubiquinone biosynthetic process (GO:0006744)4.10081532
35quinone biosynthetic process (GO:1901663)4.10081532
36chaperone-mediated protein transport (GO:0072321)4.06434448
37* hydrogen ion transmembrane transport (GO:1902600)4.06179415
38* ribonucleoside triphosphate biosynthetic process (GO:0009201)4.03968615
39protein deneddylation (GO:0000338)4.00477460
40cellular respiration (GO:0045333)3.95444657
41cardiac myofibril assembly (GO:0055003)3.91578854
42* purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.81009491
43* purine nucleoside monophosphate biosynthetic process (GO:0009127)3.81009491
44ribosomal large subunit biogenesis (GO:0042273)3.80239269
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.79822346
46regulation of sulfur metabolic process (GO:0042762)3.74633253
47rRNA modification (GO:0000154)3.71330999
48ubiquinone metabolic process (GO:0006743)3.67258077
49establishment of integrated proviral latency (GO:0075713)3.64819842
50* nucleoside triphosphate biosynthetic process (GO:0009142)3.63193385
51regulation of cellular respiration (GO:0043457)3.57710281
52ribosomal small subunit assembly (GO:0000028)3.52495065
53positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.50892983
54* proton transport (GO:0015992)3.50843076
55positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.50272996
56cardiac muscle contraction (GO:0060048)3.48928523
57* mitochondrial transport (GO:0006839)3.47925258
58branched-chain amino acid catabolic process (GO:0009083)3.46638008
59* hydrogen transport (GO:0006818)3.45861608
60regulation of oxidative phosphorylation (GO:0002082)3.45111336
61signal transduction involved in DNA integrity checkpoint (GO:0072401)3.45008337
62signal transduction involved in DNA damage checkpoint (GO:0072422)3.45008337
63L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.44052096
64myofibril assembly (GO:0030239)3.43686936
65signal transduction involved in cell cycle checkpoint (GO:0072395)3.39852245
66regulation of cellular amino acid metabolic process (GO:0006521)3.39375436
67SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.39064671
68actin-mediated cell contraction (GO:0070252)3.36510498
69cotranslational protein targeting to membrane (GO:0006613)3.36366176
70positive regulation of ligase activity (GO:0051351)3.35344072
71negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.34306858
72translation (GO:0006412)3.33455410
73protein targeting to ER (GO:0045047)3.30024525
74termination of RNA polymerase III transcription (GO:0006386)3.29697425
75transcription elongation from RNA polymerase III promoter (GO:0006385)3.29697425
76negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.29143976
77proteasome assembly (GO:0043248)3.25600238
78regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.25424247
79respiratory chain complex IV assembly (GO:0008535)3.24323708
80regulation of relaxation of muscle (GO:1901077)3.24193387
81cardiac muscle tissue morphogenesis (GO:0055008)3.24026716
82cardiac muscle cell development (GO:0055013)3.21556842
83aldehyde catabolic process (GO:0046185)3.21195504
84establishment of protein localization to endoplasmic reticulum (GO:0072599)3.20665742
85protein neddylation (GO:0045116)3.20163643
86* ribonucleoside monophosphate biosynthetic process (GO:0009156)3.20106250
87protein localization to endoplasmic reticulum (GO:0070972)3.17941566
88protein targeting to mitochondrion (GO:0006626)3.17781420
89lysine catabolic process (GO:0006554)3.16066597
90lysine metabolic process (GO:0006553)3.16066597
91translational termination (GO:0006415)3.15962361
92ribosome assembly (GO:0042255)3.15921800
93viral transcription (GO:0019083)3.15614150
94* generation of precursor metabolites and energy (GO:0006091)3.14255752
95nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.14047337
96exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11961837
97establishment of protein localization to mitochondrion (GO:0072655)3.11865330
98* purine ribonucleoside biosynthetic process (GO:0046129)3.09884849
99* purine nucleoside biosynthetic process (GO:0042451)3.09884849
100protein localization to mitochondrion (GO:0070585)3.09025046
101regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.08652455
102regulation of ubiquitin-protein transferase activity (GO:0051438)3.06747624
103pseudouridine synthesis (GO:0001522)3.05516756
104rRNA methylation (GO:0031167)3.05196702
105positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.04758100
106CENP-A containing nucleosome assembly (GO:0034080)3.04117980
107aspartate family amino acid catabolic process (GO:0009068)3.04084296
1082-oxoglutarate metabolic process (GO:0006103)3.02349669
109* nucleoside monophosphate biosynthetic process (GO:0009124)3.01879528
110cytochrome complex assembly (GO:0017004)3.00013715
111cellular component biogenesis (GO:0044085)2.98633035
112water-soluble vitamin biosynthetic process (GO:0042364)2.98605768
113DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.98063205
114translational initiation (GO:0006413)2.97098208
115negative regulation of ligase activity (GO:0051352)2.96935567
116negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.96935567
117regulation of ligase activity (GO:0051340)2.96084959
118tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.96023240
119RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.96023240
120DNA double-strand break processing (GO:0000729)2.95879339
121chromatin remodeling at centromere (GO:0031055)2.95574536
122purine nucleobase biosynthetic process (GO:0009113)2.95519936
123ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.93977804
124formation of translation preinitiation complex (GO:0001731)2.93702657
125negative regulation of potassium ion transmembrane transport (GO:1901380)2.93559431
126intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.93530483
127signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.93530483
128cardiac cell development (GO:0055006)2.92417207
129branched-chain amino acid metabolic process (GO:0009081)2.91410021
130muscle tissue morphogenesis (GO:0060415)2.90640429
131regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.90110124
132translational elongation (GO:0006414)2.89057964
133signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.87386842
134signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.87386842
135signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.87386842
136telomere maintenance via semi-conservative replication (GO:0032201)2.87357796
137spliceosomal snRNP assembly (GO:0000387)2.87029136
138quinone metabolic process (GO:1901661)2.85703552
139amino acid salvage (GO:0043102)2.83102856
140L-methionine salvage (GO:0071267)2.83102856
141L-methionine biosynthetic process (GO:0071265)2.83102856
142regulation of cellular amine metabolic process (GO:0033238)2.81576522
143establishment of viral latency (GO:0019043)2.79853128
144peptidyl-histidine modification (GO:0018202)2.79836056
145DNA strand elongation involved in DNA replication (GO:0006271)2.75976530

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.20685718
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.25685592
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.14230180
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.11744808
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.04555416
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.97368136
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.74336437
8* MYC_18555785_ChIP-Seq_MESCs_Mouse3.71801135
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.61081293
10* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.54664117
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.50980658
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.47766901
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.41819448
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.07567735
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.98764483
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.87787179
17* SRF_21415370_ChIP-Seq_HL-1_Mouse2.86722302
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82448113
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.66135534
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.55372080
21DCP1A_22483619_ChIP-Seq_HELA_Human2.46368125
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.45898100
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.43717037
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.43391486
25VDR_23849224_ChIP-Seq_CD4+_Human2.29351067
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28375466
27YY1_21170310_ChIP-Seq_MESCs_Mouse2.22223553
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20621230
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16160835
30ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.08290660
31* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04627472
32* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.03178124
33FOXP3_21729870_ChIP-Seq_TREG_Human1.99430128
34XRN2_22483619_ChIP-Seq_HELA_Human1.94788799
35ELK1_19687146_ChIP-ChIP_HELA_Human1.92500701
36GABP_19822575_ChIP-Seq_HepG2_Human1.89600238
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85109821
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78247356
39BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.78080056
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.77814364
41TTF2_22483619_ChIP-Seq_HELA_Human1.71793820
42CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.58984719
43* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57509377
44CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.57082491
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55359264
46ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.50915486
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.47920820
48VDR_22108803_ChIP-Seq_LS180_Human1.36444404
49* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35987100
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35609586
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34628813
52CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33736658
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31332435
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29676218
55GATA4_21415370_ChIP-Seq_HL-1_Mouse1.27524615
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.27254331
57ZNF274_21170338_ChIP-Seq_K562_Hela1.25319309
58E2F7_22180533_ChIP-Seq_HELA_Human1.24921426
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22582408
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.22346767
61AR_21909140_ChIP-Seq_LNCAP_Human1.21365963
62EWS_26573619_Chip-Seq_HEK293_Human1.20607743
63MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.19912942
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19462308
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18744365
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12801732
67EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12393864
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10723169
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09637293
70FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08789113
71ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07444353
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06634557
73* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05367494
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01718433
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01335685
76RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00200913
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99125573
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98910837
79NANOG_16153702_ChIP-ChIP_HESCs_Human0.98282507
80* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97671487
81MYC_18940864_ChIP-ChIP_HL60_Human0.97616229
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96910319
83SOX17_20123909_ChIP-Seq_XEN_Mouse0.96535333
84CIITA_25753668_ChIP-Seq_RAJI_Human0.93761693
85* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92694565
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92679634
87TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91761111
88* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91482618
89CTCF_18555785_ChIP-Seq_MESCs_Mouse0.91073228
90* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.90785753
91FLI1_27457419_Chip-Seq_LIVER_Mouse0.89921351
92FOXM1_23109430_ChIP-Seq_U2OS_Human0.89667166
93IGF1R_20145208_ChIP-Seq_DFB_Human0.89535938
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87352680
95SOX2_16153702_ChIP-ChIP_HESCs_Human0.86695571
96TP53_22573176_ChIP-Seq_HFKS_Human0.86324561
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86075501
98EP300_21415370_ChIP-Seq_HL-1_Mouse0.84020569
99POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83525571
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83459841
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82218489
102SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81627237
103IRF1_19129219_ChIP-ChIP_H3396_Human0.79296616
104PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.78765121
105NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.77788979
106HTT_18923047_ChIP-ChIP_STHdh_Human0.77556895
107KDM5A_27292631_Chip-Seq_BREAST_Human0.77011576
108CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.76582102
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.75701973
110ELF5_23300383_ChIP-Seq_T47D_Human0.75570040
111EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.75162989
112OCT4_18692474_ChIP-Seq_MEFs_Mouse0.73069540
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.72046168
114POU5F1_16153702_ChIP-ChIP_HESCs_Human0.71670516
115FUS_26573619_Chip-Seq_HEK293_Human0.71168729
116AR_20517297_ChIP-Seq_VCAP_Human0.70726659
117SOX2_18692474_ChIP-Seq_MEFs_Mouse0.70613385
118* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.70342813
119SALL1_21062744_ChIP-ChIP_HESCs_Human0.70321530
120GATA1_22025678_ChIP-Seq_K562_Human0.70137057
121REST_19997604_ChIP-ChIP_NEURONS_Mouse0.69692290
122HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.69117725
123ERG_20517297_ChIP-Seq_VCAP_Human0.68145983
124SALL4_22934838_ChIP-ChIP_CD34+_Human0.67922726

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.00435454
2MP0003646_muscle_fatigue4.91661697
3MP0004084_abnormal_cardiac_muscle4.73643431
4MP0004215_abnormal_myocardial_fiber4.25856865
5MP0006036_abnormal_mitochondrial_physio3.97623614
6MP0000751_myopathy3.81326213
7MP0004036_abnormal_muscle_relaxation3.71784709
8MP0000749_muscle_degeneration3.60951387
9MP0005330_cardiomyopathy3.37950912
10MP0008058_abnormal_DNA_repair3.31850586
11MP0003806_abnormal_nucleotide_metabolis3.10100180
12MP0006035_abnormal_mitochondrial_morpho2.82345911
13MP0002972_abnormal_cardiac_muscle2.66876020
14MP0008775_abnormal_heart_ventricle2.35234672
15MP0005620_abnormal_muscle_contractility2.34627981
16MP0003221_abnormal_cardiomyocyte_apopto2.32547775
17MP0003137_abnormal_impulse_conducting2.30467000
18MP0001529_abnormal_vocalization2.27725578
19MP0004484_altered_response_of2.19730773
20MP0004087_abnormal_muscle_fiber2.16179369
21MP0001544_abnormal_cardiovascular_syste2.12906381
22MP0005385_cardiovascular_system_phenoty2.12906381
23MP0002106_abnormal_muscle_physiology2.06374457
24MP0004043_abnormal_pH_regulation2.06160120
25MP0003111_abnormal_nucleus_morphology2.06106514
26MP0002269_muscular_atrophy2.04054981
27MP0003077_abnormal_cell_cycle1.98769153
28MP0003786_premature_aging1.97474244
29MP0000750_abnormal_muscle_regeneration1.96518075
30MP0006138_congestive_heart_failure1.96440516
31MP0004145_abnormal_muscle_electrophysio1.91451588
32MP0002332_abnormal_exercise_endurance1.80265149
33MP0003186_abnormal_redox_activity1.72388080
34MP0004147_increased_porphyrin_level1.71278365
35MP0002938_white_spotting1.70037635
36MP0004085_abnormal_heartbeat1.64946294
37MP0005369_muscle_phenotype1.63933682
38MP0006072_abnormal_retinal_apoptosis1.63864980
39MP0003195_calcinosis1.63667482
40MP0000747_muscle_weakness1.62871247
41MP0005266_abnormal_metabolism1.62808700
42MP0004130_abnormal_muscle_cell1.61951650
43MP0002102_abnormal_ear_morphology1.59587550
44MP0003941_abnormal_skin_development1.59419655
45MP0010630_abnormal_cardiac_muscle1.57984213
46MP0008007_abnormal_cellular_replicative1.53455345
47MP0002127_abnormal_cardiovascular_syste1.51192449
48MP0005332_abnormal_amino_acid1.49893780
49MP0004233_abnormal_muscle_weight1.49187974
50MP0000759_abnormal_skeletal_muscle1.45623744
51MP0003567_abnormal_fetal_cardiomyocyte1.37995900
52MP0009697_abnormal_copulation1.33939860
53MP0004957_abnormal_blastocyst_morpholog1.29769252
54MP0003123_paternal_imprinting1.29681951
55MP0008995_early_reproductive_senescence1.27094087
56MP0005360_urolithiasis1.21693838
57MP0002160_abnormal_reproductive_system1.09970888
58MP0001764_abnormal_homeostasis1.09818972
59MP0008789_abnormal_olfactory_epithelium1.06969476
60MP0003122_maternal_imprinting1.06881180
61MP0003828_pulmonary_edema1.05779323
62MP0000013_abnormal_adipose_tissue1.05224445
63MP0000230_abnormal_systemic_arterial1.05010187
64MP0005408_hypopigmentation1.03364252
65MP0003136_yellow_coat_color1.01523524
66MP0005085_abnormal_gallbladder_physiolo0.99625518
67MP0003950_abnormal_plasma_membrane0.98260761
68MP0001905_abnormal_dopamine_level0.97880844
69MP0005584_abnormal_enzyme/coenzyme_acti0.95488139
70MP0000358_abnormal_cell_content/0.94026098
71MP0008875_abnormal_xenobiotic_pharmacok0.93352379
72MP0005165_increased_susceptibility_to0.92898433
73MP0003011_delayed_dark_adaptation0.90404700
74MP0005319_abnormal_enzyme/_coenzyme0.89814787
75MP0005376_homeostasis/metabolism_phenot0.89270201
76MP0009379_abnormal_foot_pigmentation0.89182244
77MP0001727_abnormal_embryo_implantation0.89118725
78MP0005636_abnormal_mineral_homeostasis0.88193514
79MP0002090_abnormal_vision0.86956655
80MP0005535_abnormal_body_temperature0.86432463
81MP0004142_abnormal_muscle_tone0.85629898
82MP0005253_abnormal_eye_physiology0.84499316
83MP0002638_abnormal_pupillary_reflex0.83595570
84MP0008877_abnormal_DNA_methylation0.82740409
85MP0008057_abnormal_DNA_replication0.82431316
86MP0001661_extended_life_span0.80348248
87MP0003283_abnormal_digestive_organ0.79750563
88MP0010386_abnormal_urinary_bladder0.79612995
89MP0006276_abnormal_autonomic_nervous0.77127351
90MP0001968_abnormal_touch/_nociception0.77077403
91MP0002234_abnormal_pharynx_morphology0.76921240
92MP0005645_abnormal_hypothalamus_physiol0.76664472
93MP0005367_renal/urinary_system_phenotyp0.76493964
94MP0000516_abnormal_urinary_system0.76493964
95MP0002876_abnormal_thyroid_physiology0.76063458
96MP0005551_abnormal_eye_electrophysiolog0.75890609
97MP0005670_abnormal_white_adipose0.75304367
98MP0001929_abnormal_gametogenesis0.74930422
99MP0000343_altered_response_to0.74361303
100MP0005410_abnormal_fertilization0.74210308
101MP0002139_abnormal_hepatobiliary_system0.74202501
102MP0005386_behavior/neurological_phenoty0.73927275
103MP0004924_abnormal_behavior0.73927275
104MP0001986_abnormal_taste_sensitivity0.72550011
105MP0005646_abnormal_pituitary_gland0.72495120
106MP0001881_abnormal_mammary_gland0.72333809
107MP0001697_abnormal_embryo_size0.71762140
108MP0005171_absent_coat_pigmentation0.71662125
109MP0001666_abnormal_nutrient_absorption0.71600391
110MP0009643_abnormal_urine_homeostasis0.71198888
111MP0003880_abnormal_central_pattern0.70156243
112MP0005075_abnormal_melanosome_morpholog0.69020400
113MP0003315_abnormal_perineum_morphology0.68882736
114MP0000647_abnormal_sebaceous_gland0.67836657
115MP0005666_abnormal_adipose_tissue0.67368378
116MP0003252_abnormal_bile_duct0.66751768
117MP0002822_catalepsy0.66294849
118MP0001756_abnormal_urination0.65450370
119MP0002078_abnormal_glucose_homeostasis0.63494426
120MP0005451_abnormal_body_composition0.60644336
121MP0008932_abnormal_embryonic_tissue0.59403001
122MP0003693_abnormal_embryo_hatching0.59240674
123MP0000266_abnormal_heart_morphology0.58395759
124MP0001485_abnormal_pinna_reflex0.58358263
125MP0002163_abnormal_gland_morphology0.55797805
126MP0005084_abnormal_gallbladder_morpholo0.55712650
127MP0000372_irregular_coat_pigmentation0.50650283
128MP0005365_abnormal_bile_salt0.48875515
129MP0002971_abnormal_brown_adipose0.47768660
130MP0001984_abnormal_olfaction0.46440523
131MP0001765_abnormal_ion_homeostasis0.46036984
132MP0001730_embryonic_growth_arrest0.46010466
133MP0003718_maternal_effect0.44001922
134MP0002736_abnormal_nociception_after0.42214344
135MP0010094_abnormal_chromosome_stability0.41868341
136MP0005452_abnormal_adipose_tissue0.41212899
137MP0003984_embryonic_growth_retardation0.40663987
138MP0003121_genomic_imprinting0.40485728
139MP0008872_abnormal_physiological_respon0.40325469
140MP0005377_hearing/vestibular/ear_phenot0.38651205

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.92011682
2Abnormal mitochondria in muscle tissue (HP:0008316)6.68962949
3Acute encephalopathy (HP:0006846)6.06139959
4Mitochondrial inheritance (HP:0001427)5.81844959
5Progressive macrocephaly (HP:0004481)5.78536821
6Hepatic necrosis (HP:0002605)5.56548853
7Increased CSF lactate (HP:0002490)5.46375344
8Hepatocellular necrosis (HP:0001404)5.45758046
9Increased serum pyruvate (HP:0003542)5.22516526
10Abnormality of glycolysis (HP:0004366)5.22516526
11Cerebral edema (HP:0002181)4.76283378
12Lactic acidosis (HP:0003128)4.26534672
13Exercise intolerance (HP:0003546)4.15170216
14Exercise-induced muscle cramps (HP:0003710)4.04454628
15Sudden death (HP:0001699)4.01337824
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.00644877
17Decreased activity of mitochondrial respiratory chain (HP:0008972)4.00644877
18Respiratory failure (HP:0002878)3.97994386
19Lipid accumulation in hepatocytes (HP:0006561)3.95741005
20Increased hepatocellular lipid droplets (HP:0006565)3.85996836
21Increased intramyocellular lipid droplets (HP:0012240)3.84391484
22Myoglobinuria (HP:0002913)3.83730104
23Palpitations (HP:0001962)3.82163485
24Increased serum lactate (HP:0002151)3.81702786
25Increased muscle lipid content (HP:0009058)3.78951132
26Calf muscle hypertrophy (HP:0008981)3.64264508
27Rhabdomyolysis (HP:0003201)3.55379687
28Exercise-induced myalgia (HP:0003738)3.49351241
29Muscle hypertrophy of the lower extremities (HP:0008968)3.44547038
30Abnormality of alanine metabolism (HP:0010916)3.40172317
31Hyperalaninemia (HP:0003348)3.40172317
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.40172317
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.39537767
34Pheochromocytoma (HP:0002666)3.33870057
35Neuroendocrine neoplasm (HP:0100634)3.28703279
36Ragged-red muscle fibers (HP:0003200)3.27900058
37Ventricular tachycardia (HP:0004756)3.25904250
38Leukodystrophy (HP:0002415)3.20972768
39Conjunctival hamartoma (HP:0100780)3.19571513
40Dicarboxylic aciduria (HP:0003215)3.15760546
41Abnormality of dicarboxylic acid metabolism (HP:0010995)3.15760546
42Optic disc pallor (HP:0000543)3.12386022
43Type I transferrin isoform profile (HP:0003642)3.10072030
44Lethargy (HP:0001254)2.93542377
45Lipoatrophy (HP:0100578)2.89316574
46Generalized aminoaciduria (HP:0002909)2.87212378
47Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.84390397
48Abnormality of fatty-acid metabolism (HP:0004359)2.82928664
49Ketoacidosis (HP:0001993)2.82250135
50Renal Fanconi syndrome (HP:0001994)2.82063373
51Reduced antithrombin III activity (HP:0001976)2.80351248
52Atrial fibrillation (HP:0005110)2.80322792
53CNS demyelination (HP:0007305)2.79198092
54Hypoglycemic coma (HP:0001325)2.79048657
55Abnormal number of erythroid precursors (HP:0012131)2.76229697
56Abnormality of methionine metabolism (HP:0010901)2.68592741
57Glycosuria (HP:0003076)2.67086887
58Abnormality of urine glucose concentration (HP:0011016)2.67086887
59Neoplasm of the adrenal gland (HP:0100631)2.67043529
603-Methylglutaconic aciduria (HP:0003535)2.66457258
61Abnormality of the calf musculature (HP:0001430)2.66050903
62Abnormality of cells of the erythroid lineage (HP:0012130)2.64287561
63Supraventricular tachycardia (HP:0004755)2.62472252
64Primary atrial arrhythmia (HP:0001692)2.58812885
65Dilated cardiomyopathy (HP:0001644)2.53467137
66Supraventricular arrhythmia (HP:0005115)2.52881110
67Abnormal protein glycosylation (HP:0012346)2.52348269
68Abnormal glycosylation (HP:0012345)2.52348269
69Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.52348269
70Abnormal protein N-linked glycosylation (HP:0012347)2.52348269
71Respiratory difficulties (HP:0002880)2.52022735
72Abnormality of aspartate family amino acid metabolism (HP:0010899)2.51377059
73Methylmalonic aciduria (HP:0012120)2.50506369
74Macrocytic anemia (HP:0001972)2.49483325
75Degeneration of anterior horn cells (HP:0002398)2.46740590
76Abnormality of the anterior horn cell (HP:0006802)2.46740590
77Emotional lability (HP:0000712)2.41525478
78Hyperglycinemia (HP:0002154)2.39732618
79Proximal tubulopathy (HP:0000114)2.38634054
80Syncope (HP:0001279)2.37864167
81Muscle fiber splitting (HP:0003555)2.37455588
82Vomiting (HP:0002013)2.34283173
83Aplastic anemia (HP:0001915)2.29207896
84Esophageal neoplasm (HP:0100751)2.28125004
85Neoplasm of head and neck (HP:0012288)2.28125004
86Nausea (HP:0002018)2.27179125
87Metabolic acidosis (HP:0001942)2.25704885
88X-linked dominant inheritance (HP:0001423)2.24672613
89Exertional dyspnea (HP:0002875)2.23442208
90Ketosis (HP:0001946)2.22758799
91Hyperammonemia (HP:0001987)2.20119745
92Hyperglycinuria (HP:0003108)2.16866326
93Multiple enchondromatosis (HP:0005701)2.16129365
94Subaortic stenosis (HP:0001682)2.14131158
95Abnormality of the left ventricular outflow tract (HP:0011103)2.14131158
96Microvesicular hepatic steatosis (HP:0001414)2.13670369
97EMG: myopathic abnormalities (HP:0003458)2.13524671
98Gliosis (HP:0002171)2.12022629
99Abnormality of placental membranes (HP:0011409)2.09636466
100Amniotic constriction ring (HP:0009775)2.09636466
101Reticulocytopenia (HP:0001896)2.07677119
102Nemaline bodies (HP:0003798)2.05633857
103Prolonged QT interval (HP:0001657)2.04719113
104Congenital, generalized hypertrichosis (HP:0004540)2.03786884
105Muscle stiffness (HP:0003552)2.02178073
106Abnormality of vitamin B metabolism (HP:0004340)2.01072466
107Myotonia (HP:0002486)2.00094410
108Rimmed vacuoles (HP:0003805)1.99032876
109Abnormality of serine family amino acid metabolism (HP:0010894)1.98530690
110Abnormality of glycine metabolism (HP:0010895)1.98530690
111Left ventricular hypertrophy (HP:0001712)1.97436203
112Abnormality of the vitamin B12 metabolism (HP:0004341)1.95480144
113Abnormality of aromatic amino acid family metabolism (HP:0004338)1.95212209
114Megaloblastic anemia (HP:0001889)1.94741750
115Ventricular arrhythmia (HP:0004308)1.94529130
116Right ventricular cardiomyopathy (HP:0011663)1.93562278
117Muscle fiber inclusion bodies (HP:0100299)1.90709971
118Renal cortical cysts (HP:0000803)1.90099751
119Colon cancer (HP:0003003)1.89792885
120Abnormality of renal resorption (HP:0011038)1.88573121
121Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.88137650
122Methylmalonic acidemia (HP:0002912)1.87142792
123Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.85469796
124Hyperinsulinemic hypoglycemia (HP:0000825)1.84240897
125Hyperphosphaturia (HP:0003109)1.82584630
126Progressive external ophthalmoplegia (HP:0000590)1.82464829
127Pancytopenia (HP:0001876)1.80972044
128Neoplasm of the peripheral nervous system (HP:0100007)1.78218542
129Abnormality of serum amino acid levels (HP:0003112)1.75804315
130Tinnitus (HP:0000360)1.75083224
131Oral leukoplakia (HP:0002745)1.73616931
132Hypothermia (HP:0002045)1.70776243
133Abnormality of sulfur amino acid metabolism (HP:0004339)1.69818469
134Testicular atrophy (HP:0000029)1.67751995
135Gout (HP:0001997)1.60634895

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.27258982
2VRK24.11456084
3MYLK3.95822346
4PDK33.66192603
5PDK43.66192603
6BCKDK3.63588344
7NEK13.28383787
8NME13.08004690
9NME22.73492122
10EIF2AK12.63495538
11BUB12.37863587
12PDK22.16641152
13MAP3K122.12743460
14STK242.10944984
15TTN2.10087328
16LMTK21.99166322
17STK161.95541435
18NUAK11.95271815
19PHKG11.93977444
20PHKG21.93977444
21SCYL21.88592171
22WEE11.85636381
23MAP4K21.72213825
24WNK41.60211874
25GRK71.60106390
26WNK31.58262019
27EIF2AK31.58045609
28ILK1.52616524
29STK38L1.46084936
30MST41.44108020
31MUSK1.40994268
32LIMK11.38991928
33ARAF1.38124681
34ZAK1.37909883
35TRIM281.27521817
36TSSK61.24726210
37TLK11.23438223
38PIK3CA1.23053607
39VRK11.18810700
40PINK11.17132986
41PBK1.13808943
42BRSK21.13150507
43CCNB11.11223563
44CSNK1G31.04440630
45PLK21.00407004
46TAF10.99729573
47MKNK10.98545982
48FLT30.95424996
49CDK80.94724999
50EIF2AK20.94394727
51OXSR10.93532609
52MAP2K70.90869469
53PKN20.89459676
54CSNK1G10.88843841
55TESK20.86874721
56TIE10.85671164
57STK390.85281927
58CAMK2D0.85099282
59ACVR1B0.83332618
60MAP3K40.83032050
61SRPK10.80728995
62BCR0.80315895
63BRAF0.78219461
64CSNK1G20.77728868
65ERBB30.76372428
66PAK40.76339431
67TNIK0.75933019
68CSNK1A1L0.74934494
69INSRR0.73788370
70MKNK20.73743724
71TESK10.71455274
72GRK10.71445903
73MAP2K40.70166556
74CHEK20.69369484
75GRK50.69295145
76PASK0.68608905
77PLK30.68506347
78ATR0.67779367
79DAPK30.65237140
80MAP3K30.63640912
81KDR0.61006246
82RPS6KA50.58762296
83PAK30.57673949
84CAMK2A0.57616964
85CAMK2G0.57451703
86PIM20.57098856
87PIK3CG0.56202427
88CDC70.56156520
89DAPK10.53435289
90ABL20.52807958
91CDK190.49267243
92RPS6KB20.49047182
93AURKB0.48521322
94PRKACA0.48263903
95BRSK10.46435803
96AURKA0.46025348
97PLK10.45825968
98CSNK2A10.45401973
99MAPKAPK50.45256377
100MAP3K50.43986556
101ADRBK10.43487510
102MAPKAPK30.42522318
103MAPK120.42308355
104ADRBK20.42035175
105MAP3K110.41669207
106CASK0.41295173
107ATM0.40748381
108PLK40.39633031
109BMPR1B0.38993565
110CAMK2B0.38223530
111GRK60.38181658
112CSNK2A20.37357722
113MAP2K60.36755936
114NEK20.34971127
115DYRK20.34803347
116MAP2K30.34777759
117TGFBR10.34437987
118PRKACB0.33686790
119NEK90.33472244
120CSNK1E0.33465930
121STK40.32992035
122BMPR20.32896747
123TTK0.32718932
124PRKCE0.32552736
125PTK2B0.30941805
126CDK70.30004302
127PRKCG0.29679998
128ROCK20.28902764
129PRKCI0.28222302
130AKT20.28194159
131CHEK10.27562546
132FRK0.26790145
133TAOK20.25463988
134ROCK10.25340494

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.26231713
2* Oxidative phosphorylation_Homo sapiens_hsa001905.15477674
3Parkinsons disease_Homo sapiens_hsa050124.72233095
4Alzheimers disease_Homo sapiens_hsa050103.33479389
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.31893511
6Proteasome_Homo sapiens_hsa030503.22771435
7Huntingtons disease_Homo sapiens_hsa050163.22397532
8Cardiac muscle contraction_Homo sapiens_hsa042602.98623293
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.88752299
10Propanoate metabolism_Homo sapiens_hsa006402.81435625
11Carbon metabolism_Homo sapiens_hsa012002.39473026
12Pyruvate metabolism_Homo sapiens_hsa006202.36068704
13Ribosome_Homo sapiens_hsa030102.23249415
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.17555918
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.07783543
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.79062338
17Fatty acid degradation_Homo sapiens_hsa000711.77650320
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68164383
19Fatty acid elongation_Homo sapiens_hsa000621.65297376
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56624988
21RNA polymerase_Homo sapiens_hsa030201.52457290
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.50033592
23Protein export_Homo sapiens_hsa030601.47781982
24Biosynthesis of amino acids_Homo sapiens_hsa012301.44160270
25Butanoate metabolism_Homo sapiens_hsa006501.43475080
26Fatty acid metabolism_Homo sapiens_hsa012121.39836095
27Mismatch repair_Homo sapiens_hsa034301.12298224
28Sulfur metabolism_Homo sapiens_hsa009201.11168549
29Fanconi anemia pathway_Homo sapiens_hsa034601.11043807
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.10349427
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09352884
32DNA replication_Homo sapiens_hsa030301.08652526
33Collecting duct acid secretion_Homo sapiens_hsa049661.03230776
34Pyrimidine metabolism_Homo sapiens_hsa002401.01143673
35Peroxisome_Homo sapiens_hsa041461.00047028
36Caffeine metabolism_Homo sapiens_hsa002320.97811779
37Nitrogen metabolism_Homo sapiens_hsa009100.93752343
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93688689
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91663296
40* Metabolic pathways_Homo sapiens_hsa011000.88103098
41Fructose and mannose metabolism_Homo sapiens_hsa000510.87056533
42Dilated cardiomyopathy_Homo sapiens_hsa054140.85207124
43beta-Alanine metabolism_Homo sapiens_hsa004100.79694572
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79637169
45Phenylalanine metabolism_Homo sapiens_hsa003600.79620245
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78627318
47Glutathione metabolism_Homo sapiens_hsa004800.76109149
48Galactose metabolism_Homo sapiens_hsa000520.73119842
49Nucleotide excision repair_Homo sapiens_hsa034200.72430311
50Arginine and proline metabolism_Homo sapiens_hsa003300.71417465
51Tryptophan metabolism_Homo sapiens_hsa003800.69876349
52Purine metabolism_Homo sapiens_hsa002300.69199660
53Folate biosynthesis_Homo sapiens_hsa007900.68952938
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.67526186
55Vibrio cholerae infection_Homo sapiens_hsa051100.67257439
56Pentose phosphate pathway_Homo sapiens_hsa000300.65420836
57Tyrosine metabolism_Homo sapiens_hsa003500.65060695
58Steroid biosynthesis_Homo sapiens_hsa001000.62682541
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62156803
60Spliceosome_Homo sapiens_hsa030400.60334443
61RNA transport_Homo sapiens_hsa030130.59299606
62Vitamin digestion and absorption_Homo sapiens_hsa049770.59283810
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57449137
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.57024835
65Retinol metabolism_Homo sapiens_hsa008300.53629737
66Homologous recombination_Homo sapiens_hsa034400.53433954
67RNA degradation_Homo sapiens_hsa030180.53280456
68Starch and sucrose metabolism_Homo sapiens_hsa005000.52141660
69N-Glycan biosynthesis_Homo sapiens_hsa005100.50710830
70Base excision repair_Homo sapiens_hsa034100.47420019
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47400858
72PPAR signaling pathway_Homo sapiens_hsa033200.46534650
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43462725
74Linoleic acid metabolism_Homo sapiens_hsa005910.41767928
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.40595402
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40590414
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38564299
78Systemic lupus erythematosus_Homo sapiens_hsa053220.37032904
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35465863
80Glucagon signaling pathway_Homo sapiens_hsa049220.33745452
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.33287602
82Basal transcription factors_Homo sapiens_hsa030220.32938807
83Oocyte meiosis_Homo sapiens_hsa041140.32487888
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30373656
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29584723
86Mineral absorption_Homo sapiens_hsa049780.28878786
87Arginine biosynthesis_Homo sapiens_hsa002200.28753098
88Regulation of autophagy_Homo sapiens_hsa041400.28106960
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28060492
90One carbon pool by folate_Homo sapiens_hsa006700.26473423
91Non-homologous end-joining_Homo sapiens_hsa034500.25393767
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24825109
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24383083
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24160157
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22941120
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22736967
97Phototransduction_Homo sapiens_hsa047440.22545980
98Sulfur relay system_Homo sapiens_hsa041220.21888914
99Vitamin B6 metabolism_Homo sapiens_hsa007500.21710749
100Arachidonic acid metabolism_Homo sapiens_hsa005900.20668000
101Selenocompound metabolism_Homo sapiens_hsa004500.17143773
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.17120409
103Fat digestion and absorption_Homo sapiens_hsa049750.16318358
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.12992228
105Chemical carcinogenesis_Homo sapiens_hsa052040.12981367
106Histidine metabolism_Homo sapiens_hsa003400.12083046
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.11894974
108Calcium signaling pathway_Homo sapiens_hsa040200.11752793
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.07664746
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.05372665
111Cell cycle_Homo sapiens_hsa041100.03237656
112Viral myocarditis_Homo sapiens_hsa054160.02867092
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.02341438
114HIF-1 signaling pathway_Homo sapiens_hsa040660.01344860
115Glycerolipid metabolism_Homo sapiens_hsa005610.01218327
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.0176906
117Renin-angiotensin system_Homo sapiens_hsa04614-0.0159005

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