ATP2B3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)6.38502300
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.27394779
3synaptic vesicle maturation (GO:0016188)6.17210222
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.91656127
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.59924303
6vocalization behavior (GO:0071625)5.47776750
7ionotropic glutamate receptor signaling pathway (GO:0035235)5.37783969
8neuronal action potential propagation (GO:0019227)5.30803603
9synaptic vesicle exocytosis (GO:0016079)5.22202712
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.15568170
11glutamate secretion (GO:0014047)5.02878366
12cellular potassium ion homeostasis (GO:0030007)4.96273444
13sodium ion export (GO:0071436)4.89367774
14glutamate receptor signaling pathway (GO:0007215)4.83057667
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.80352848
16regulation of glutamate receptor signaling pathway (GO:1900449)4.79063751
17regulation of synaptic vesicle exocytosis (GO:2000300)4.78270548
18gamma-aminobutyric acid transport (GO:0015812)4.72859590
19synaptic transmission, glutamatergic (GO:0035249)4.72142232
20neurotransmitter secretion (GO:0007269)4.71274760
21exploration behavior (GO:0035640)4.66650727
22cerebellar Purkinje cell differentiation (GO:0021702)4.55910814
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.47981935
24long-term memory (GO:0007616)4.46286882
25regulation of neuronal synaptic plasticity (GO:0048168)4.44938538
26regulation of synaptic vesicle transport (GO:1902803)4.32477512
27cerebellar granule cell differentiation (GO:0021707)4.28805597
28protein localization to synapse (GO:0035418)4.26693212
29cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.26298945
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.26131905
31neuron-neuron synaptic transmission (GO:0007270)4.23988761
32amino acid import (GO:0043090)4.21717180
33neuromuscular process controlling posture (GO:0050884)4.17249105
34positive regulation of synapse maturation (GO:0090129)4.14682478
35G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.11189827
36regulation of voltage-gated calcium channel activity (GO:1901385)4.10757302
37regulation of synapse structural plasticity (GO:0051823)4.09384840
38neurotransmitter-gated ion channel clustering (GO:0072578)4.04232386
39postsynaptic membrane organization (GO:0001941)4.03009866
40layer formation in cerebral cortex (GO:0021819)4.02908312
41regulation of excitatory postsynaptic membrane potential (GO:0060079)3.99642340
42positive regulation of membrane potential (GO:0045838)3.94224828
43neuron cell-cell adhesion (GO:0007158)3.93596251
44cell communication by electrical coupling (GO:0010644)3.90734396
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.88458458
46neuromuscular process controlling balance (GO:0050885)3.83293646
47positive regulation of dendritic spine development (GO:0060999)3.82172652
48proline transport (GO:0015824)3.79982173
49regulation of postsynaptic membrane potential (GO:0060078)3.79863443
50neurotransmitter transport (GO:0006836)3.78452567
51positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.77422810
52negative regulation of dendrite morphogenesis (GO:0050774)3.73231056
53dendritic spine morphogenesis (GO:0060997)3.72871123
54positive regulation of dendritic spine morphogenesis (GO:0061003)3.70635077
55gamma-aminobutyric acid signaling pathway (GO:0007214)3.67354407
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.67005050
57central nervous system myelination (GO:0022010)3.63229004
58axon ensheathment in central nervous system (GO:0032291)3.63229004
59membrane depolarization during action potential (GO:0086010)3.62858047
60potassium ion import (GO:0010107)3.59489769
61cellular sodium ion homeostasis (GO:0006883)3.58576284
62activation of protein kinase A activity (GO:0034199)3.57523728
63glycine transport (GO:0015816)3.56702624
64transmission of nerve impulse (GO:0019226)3.56655571
65regulation of neurotransmitter levels (GO:0001505)3.56224426
66synaptic vesicle endocytosis (GO:0048488)3.55458977
67positive regulation of neurotransmitter transport (GO:0051590)3.55270333
68regulation of synaptic plasticity (GO:0048167)3.54777279
69positive regulation of neurotransmitter secretion (GO:0001956)3.53055004
70cell differentiation in hindbrain (GO:0021533)3.49761175
71regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.46642390
72response to pheromone (GO:0019236)3.44092997
73regulation of synaptic transmission, glutamatergic (GO:0051966)3.41102119
74L-amino acid import (GO:0043092)3.40810676
75regulation of neurotransmitter secretion (GO:0046928)3.40089390
76membrane depolarization (GO:0051899)3.39847110
77neuromuscular synaptic transmission (GO:0007274)3.39748464
78acidic amino acid transport (GO:0015800)3.39455589
79regulation of ARF protein signal transduction (GO:0032012)3.38705646
80membrane hyperpolarization (GO:0060081)3.34081888
81dendrite morphogenesis (GO:0048813)3.33261228
82neurotransmitter uptake (GO:0001504)3.30550544
83regulation of dendritic spine development (GO:0060998)3.28838405
84regulation of dendritic spine morphogenesis (GO:0061001)3.27816781
85prepulse inhibition (GO:0060134)3.25405316
86long-term synaptic potentiation (GO:0060291)3.24004418
87innervation (GO:0060384)3.23129730
88potassium ion homeostasis (GO:0055075)3.22696747
89establishment of nucleus localization (GO:0040023)3.22395485
90chemosensory behavior (GO:0007635)3.21839962
91positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.21632527
92establishment of synaptic vesicle localization (GO:0097480)3.21536872
93synaptic vesicle transport (GO:0048489)3.21536872
94neuromuscular process (GO:0050905)3.19764170
95auditory behavior (GO:0031223)3.19008864
96negative regulation of synaptic transmission, GABAergic (GO:0032229)3.16475346
97adult walking behavior (GO:0007628)3.16249306
98regulation of clathrin-mediated endocytosis (GO:2000369)3.15797969
99negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.15256797
100regulation of synapse maturation (GO:0090128)3.15037984
101regulation of neurotransmitter transport (GO:0051588)3.14365161
102response to auditory stimulus (GO:0010996)3.13815451
103positive regulation of potassium ion transmembrane transport (GO:1901381)3.11262350
104G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.08701076
105regulation of vesicle fusion (GO:0031338)3.08331362
106behavioral defense response (GO:0002209)3.04899162
107behavioral fear response (GO:0001662)3.04899162
108vesicle docking involved in exocytosis (GO:0006904)3.04093109
109presynaptic membrane organization (GO:0097090)3.04022325
110regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.03752645
111neuron recognition (GO:0008038)3.03698243
112cell communication involved in cardiac conduction (GO:0086065)3.03211597
113learning (GO:0007612)3.02799260
114cytoskeletal anchoring at plasma membrane (GO:0007016)3.02441978
115serotonin metabolic process (GO:0042428)3.01896779
116long term synaptic depression (GO:0060292)3.01368340
117detection of calcium ion (GO:0005513)3.00175975
118regulation of synaptic transmission (GO:0050804)2.99823148
119neuronal ion channel clustering (GO:0045161)2.99349915
120synaptic transmission (GO:0007268)2.98467786
121positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.95917523
122negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.95370425
123axonal fasciculation (GO:0007413)2.94770998

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.99768103
2GBX2_23144817_ChIP-Seq_PC3_Human3.24516921
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10635703
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.06878673
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95706482
6DROSHA_22980978_ChIP-Seq_HELA_Human2.89627115
7REST_21632747_ChIP-Seq_MESCs_Mouse2.78584456
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75338288
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75338288
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60553925
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.58836135
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.55111969
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.51748071
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49903586
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48020879
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.44685418
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41276601
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.35520092
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.28373574
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.26541480
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.24668541
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.23820608
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.22107407
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16978103
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.14888472
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09489359
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.93330476
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77066305
29AR_21572438_ChIP-Seq_LNCaP_Human1.76503053
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71791700
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67553238
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.66573165
33SMAD4_21799915_ChIP-Seq_A2780_Human1.61747505
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53562906
35ZNF274_21170338_ChIP-Seq_K562_Hela1.48228904
36RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36472478
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35075355
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32683231
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31776957
40* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31702054
41* AR_19668381_ChIP-Seq_PC3_Human1.30916987
42NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29848891
43SOX2_21211035_ChIP-Seq_LN229_Gbm1.28327121
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.27710338
45KDM2B_26808549_Chip-Seq_K562_Human1.27001737
46RNF2_27304074_Chip-Seq_NSC_Mouse1.25374110
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23142098
48STAT3_23295773_ChIP-Seq_U87_Human1.23115377
49WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22999602
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21709474
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.21283416
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19606702
53GATA1_26923725_Chip-Seq_HPCs_Mouse1.19601687
54AR_25329375_ChIP-Seq_VCAP_Human1.18470802
55EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17144477
56TP53_16413492_ChIP-PET_HCT116_Human1.14364298
57GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13418704
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13374845
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11422899
60CTCF_27219007_Chip-Seq_Bcells_Human1.10608886
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.09651104
62P300_19829295_ChIP-Seq_ESCs_Human1.09006166
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07980018
64OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07945846
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07567893
66TAF15_26573619_Chip-Seq_HEK293_Human1.07334061
67TCF4_23295773_ChIP-Seq_U87_Human1.06982574
68ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06840014
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.05681822
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.04762996
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04732202
72RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02848605
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02667429
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02451378
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02415285
76IGF1R_20145208_ChIP-Seq_DFB_Human1.02054624
77AHR_22903824_ChIP-Seq_MCF-7_Human1.01502516
78YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01447568
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00673476
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99818006
81PIAS1_25552417_ChIP-Seq_VCAP_Human0.99583478
82SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98568189
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98256814
84SMAD4_21741376_ChIP-Seq_HESCs_Human0.97514454
85SMAD3_21741376_ChIP-Seq_ESCs_Human0.97217000
86P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96395245
87TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96374245
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94863939
89RXR_22108803_ChIP-Seq_LS180_Human0.94599843
90SMAD3_21741376_ChIP-Seq_HESCs_Human0.94243372
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93914319
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93518157
93* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93515099
94CBX2_27304074_Chip-Seq_ESCs_Mouse0.92760036
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92465911
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91894982
97TET1_21490601_ChIP-Seq_MESCs_Mouse0.91374978
98CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89958332
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89707130
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89350549
101ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89205929
102RUNX2_22187159_ChIP-Seq_PCA_Human0.88679370
103GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87830131
104NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87629378
105SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86810686
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86575152
107SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86476937
108SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86405672
109DPY_21335234_ChIP-Seq_ESCs_Mouse0.84065253
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83594686
111TP53_20018659_ChIP-ChIP_R1E_Mouse0.83066406
112DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81604168
113LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80707088
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80641424
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.80641424
116* OCT4_19829295_ChIP-Seq_ESCs_Human0.79937545
117FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.75151630
118EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.74884253
119ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.73613360
120SOX9_26525672_Chip-Seq_HEART_Mouse0.73505443
121LXR_22292898_ChIP-Seq_THP-1_Human0.73213564

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.06056559
2MP0003635_abnormal_synaptic_transmissio4.36450265
3MP0003880_abnormal_central_pattern4.19524320
4MP0009046_muscle_twitch3.96422031
5MP0004270_analgesia3.65516068
6MP0009745_abnormal_behavioral_response3.51498937
7MP0002064_seizures3.33794479
8MP0002063_abnormal_learning/memory/cond3.30814270
9MP0005423_abnormal_somatic_nervous2.96066939
10MP0001968_abnormal_touch/_nociception2.93362491
11MP0002272_abnormal_nervous_system2.87344785
12MP0002572_abnormal_emotion/affect_behav2.84606190
13MP0002734_abnormal_mechanical_nocicepti2.68097738
14MP0008569_lethality_at_weaning2.58295902
15MP0001486_abnormal_startle_reflex2.56176927
16MP0001501_abnormal_sleep_pattern2.43002609
17MP0002735_abnormal_chemical_nociception2.29558260
18MP0002822_catalepsy2.26467686
19MP0002736_abnormal_nociception_after2.25124933
20MP0001440_abnormal_grooming_behavior2.19527131
21MP0002067_abnormal_sensory_capabilities2.17065975
22MP0002733_abnormal_thermal_nociception1.96485950
23MP0002184_abnormal_innervation1.94784033
24MP0004858_abnormal_nervous_system1.91954164
25MP0001970_abnormal_pain_threshold1.91927842
26MP0003329_amyloid_beta_deposits1.86666123
27MP0004811_abnormal_neuron_physiology1.75277853
28MP0002557_abnormal_social/conspecific_i1.73908580
29MP0002909_abnormal_adrenal_gland1.73894036
30MP0009780_abnormal_chondrocyte_physiolo1.72335519
31MP0004924_abnormal_behavior1.69725691
32MP0005386_behavior/neurological_phenoty1.69725691
33MP0004145_abnormal_muscle_electrophysio1.69418088
34MP0003879_abnormal_hair_cell1.63635320
35MP0004885_abnormal_endolymph1.61753110
36MP0003633_abnormal_nervous_system1.56945129
37MP0000955_abnormal_spinal_cord1.56402370
38MP0000778_abnormal_nervous_system1.54571774
39MP0002066_abnormal_motor_capabilities/c1.50075369
40MP0005646_abnormal_pituitary_gland1.46240174
41MP0003787_abnormal_imprinting1.45464529
42MP0004142_abnormal_muscle_tone1.45044985
43MP0002882_abnormal_neuron_morphology1.39342684
44MP0003631_nervous_system_phenotype1.36071374
45MP0005645_abnormal_hypothalamus_physiol1.29301588
46MP0000569_abnormal_digit_pigmentation1.28249691
47MP0003123_paternal_imprinting1.26021538
48MP0001502_abnormal_circadian_rhythm1.24490343
49MP0001984_abnormal_olfaction1.22711830
50MP0008872_abnormal_physiological_respon1.16159458
51MP0003690_abnormal_glial_cell1.15350464
52MP0003632_abnormal_nervous_system1.15224489
53MP0006276_abnormal_autonomic_nervous1.14267713
54MP0002152_abnormal_brain_morphology1.10179216
55MP0002229_neurodegeneration1.06351136
56MP0001348_abnormal_lacrimal_gland1.04416926
57MP0003122_maternal_imprinting1.03147037
58MP0000920_abnormal_myelination0.98723413
59MP0003075_altered_response_to0.98610294
60MP0004742_abnormal_vestibular_system0.98143917
61MP0000751_myopathy0.97823369
62MP0001177_atelectasis0.96941100
63MP0008874_decreased_physiological_sensi0.96065633
64MP0003283_abnormal_digestive_organ0.92679434
65MP0002069_abnormal_eating/drinking_beha0.91146365
66MP0001986_abnormal_taste_sensitivity0.89628698
67MP0008961_abnormal_basal_metabolism0.87274318
68MP0001905_abnormal_dopamine_level0.86179844
69MP0000604_amyloidosis0.84745903
70MP0008877_abnormal_DNA_methylation0.84381557
71MP0003634_abnormal_glial_cell0.83316358
72MP0004510_myositis0.82014808
73MP0005551_abnormal_eye_electrophysiolog0.81945869
74MP0004215_abnormal_myocardial_fiber0.81832797
75MP0004085_abnormal_heartbeat0.81822556
76MP0001346_abnormal_lacrimal_gland0.81003408
77MP0005535_abnormal_body_temperature0.79720625
78MP0004233_abnormal_muscle_weight0.78956633
79MP0005167_abnormal_blood-brain_barrier0.78370232
80MP0004043_abnormal_pH_regulation0.78305763
81MP0003045_fibrosis0.77231657
82MP0003172_abnormal_lysosome_physiology0.76665879
83MP0001188_hyperpigmentation0.75296679
84MP0001963_abnormal_hearing_physiology0.74560957
85MP0003137_abnormal_impulse_conducting0.73641127
86MP0000013_abnormal_adipose_tissue0.72817815
87MP0004484_altered_response_of0.71943748
88MP0001299_abnormal_eye_distance/0.70592884
89MP0005623_abnormal_meninges_morphology0.68181128
90MP0003646_muscle_fatigue0.67490965
91MP0001485_abnormal_pinna_reflex0.67286595
92MP0003121_genomic_imprinting0.66503861
93MP0010386_abnormal_urinary_bladder0.66321124
94MP0001529_abnormal_vocalization0.65890622
95MP0002752_abnormal_somatic_nervous0.65277803
96MP0004147_increased_porphyrin_level0.63841713
97MP0002090_abnormal_vision0.61892294
98MP0010769_abnormal_survival0.59636184
99MP0002089_abnormal_postnatal_growth/wei0.59086481
100MP0000747_muscle_weakness0.57947637
101MP0002638_abnormal_pupillary_reflex0.57128148
102MP0001943_abnormal_respiration0.56686680
103MP0005409_darkened_coat_color0.56301864
104MP0010768_mortality/aging0.56050833
105MP0004130_abnormal_muscle_cell0.55893663
106MP0003861_abnormal_nervous_system0.55756561
107MP0005499_abnormal_olfactory_system0.55009342
108MP0005394_taste/olfaction_phenotype0.55009342
109MP0010770_preweaning_lethality0.54955674
110MP0002082_postnatal_lethality0.54955674
111MP0000639_abnormal_adrenal_gland0.54054475
112MP0003956_abnormal_body_size0.51727041
113MP0000631_abnormal_neuroendocrine_gland0.49228810
114MP0000026_abnormal_inner_ear0.46551127
115MP0000579_abnormal_nail_morphology0.44496560

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.64178694
2Myokymia (HP:0002411)7.04763915
3Focal seizures (HP:0007359)5.96928205
4Progressive cerebellar ataxia (HP:0002073)5.66086789
5Visual hallucinations (HP:0002367)5.64132821
6Atonic seizures (HP:0010819)4.55217788
7Febrile seizures (HP:0002373)4.53804887
8Gaze-evoked nystagmus (HP:0000640)4.48644637
9Epileptic encephalopathy (HP:0200134)4.46385727
10* Action tremor (HP:0002345)4.18459366
11Absence seizures (HP:0002121)4.15340771
12Dysdiadochokinesis (HP:0002075)3.94227910
13Generalized tonic-clonic seizures (HP:0002069)3.88116590
14Dialeptic seizures (HP:0011146)3.76638045
15Broad-based gait (HP:0002136)3.76609816
16Hemiplegia (HP:0002301)3.70152837
17Dysmetria (HP:0001310)3.66871411
18Impaired smooth pursuit (HP:0007772)3.66857864
19Scanning speech (HP:0002168)3.62010887
20Poor eye contact (HP:0000817)3.59485693
21Limb dystonia (HP:0002451)3.59258751
22Supranuclear gaze palsy (HP:0000605)3.55024233
23Genetic anticipation (HP:0003743)3.54954846
24Dysmetric saccades (HP:0000641)3.52301835
25Truncal ataxia (HP:0002078)3.51482277
26Depression (HP:0000716)3.42758306
27Abnormality of ocular smooth pursuit (HP:0000617)3.36436838
28Postural instability (HP:0002172)3.32902546
29Mutism (HP:0002300)3.32506547
30Abnormality of the lower motor neuron (HP:0002366)3.32102210
31Abnormal social behavior (HP:0012433)3.31352649
32Impaired social interactions (HP:0000735)3.31352649
33Impaired vibration sensation in the lower limbs (HP:0002166)3.29190490
34Ankle clonus (HP:0011448)3.24915091
35Cerebral hypomyelination (HP:0006808)3.21781173
36Hemiparesis (HP:0001269)3.20370092
37Ventricular fibrillation (HP:0001663)3.11306627
38Abnormality of binocular vision (HP:0011514)3.06423326
39Diplopia (HP:0000651)3.06423326
40Anxiety (HP:0000739)3.01367112
41Urinary bladder sphincter dysfunction (HP:0002839)2.98508957
42Abnormal eating behavior (HP:0100738)2.96178808
43Akinesia (HP:0002304)2.87901562
44Annular pancreas (HP:0001734)2.82810849
45* Intention tremor (HP:0002080)2.78528032
46Status epilepticus (HP:0002133)2.76084978
47Delusions (HP:0000746)2.67133360
48Tetraplegia (HP:0002445)2.64223576
49Papilledema (HP:0001085)2.60403782
50Spastic gait (HP:0002064)2.57665185
51Sleep apnea (HP:0010535)2.53770157
52Urinary urgency (HP:0000012)2.51524488
53Stereotypic behavior (HP:0000733)2.51174606
54Excessive salivation (HP:0003781)2.49010746
55Drooling (HP:0002307)2.49010746
56Hyperventilation (HP:0002883)2.47215920
57Bradykinesia (HP:0002067)2.47022953
58Torticollis (HP:0000473)2.44892552
59Abnormality of saccadic eye movements (HP:0000570)2.42577248
60Amblyopia (HP:0000646)2.41950687
61Peripheral hypomyelination (HP:0007182)2.37279163
62Agitation (HP:0000713)2.37125820
63Polyphagia (HP:0002591)2.35961440
64Focal dystonia (HP:0004373)2.35898679
65Bundle branch block (HP:0011710)2.35085214
66Abnormality of the corticospinal tract (HP:0002492)2.34309361
67Impaired vibratory sensation (HP:0002495)2.31949100
68Apathy (HP:0000741)2.31432010
69Postural tremor (HP:0002174)2.28470101
70Progressive inability to walk (HP:0002505)2.28177919
71Pointed chin (HP:0000307)2.27986331
72Fetal akinesia sequence (HP:0001989)2.25732383
73Gait ataxia (HP:0002066)2.23965835
74Epileptiform EEG discharges (HP:0011182)2.22559685
75Neuronal loss in central nervous system (HP:0002529)2.19193649
76Choreoathetosis (HP:0001266)2.16183280
77Rapidly progressive (HP:0003678)2.16090136
78Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.14602340
79Degeneration of the lateral corticospinal tracts (HP:0002314)2.14602340
80CNS hypomyelination (HP:0003429)2.14088871
81Neurofibrillary tangles (HP:0002185)2.13710790
82EEG with generalized epileptiform discharges (HP:0011198)2.12375889
83Lower limb asymmetry (HP:0100559)2.11151104
84Limb ataxia (HP:0002070)2.10080455
85Incomplete penetrance (HP:0003829)2.07698532
86Megalencephaly (HP:0001355)2.07531423
87Clonus (HP:0002169)2.04831315
88Horizontal nystagmus (HP:0000666)2.04458526
89Diminished motivation (HP:0000745)2.03799984
90Hypsarrhythmia (HP:0002521)2.02550438
91Cerebral inclusion bodies (HP:0100314)2.01339287
92Pheochromocytoma (HP:0002666)1.99766365
93Psychosis (HP:0000709)1.97700800
94Absent speech (HP:0001344)1.96969966
95Craniofacial dystonia (HP:0012179)1.96614757
96Lower limb muscle weakness (HP:0007340)1.94737332
97Abnormal EKG (HP:0003115)1.94577987
98Insomnia (HP:0100785)1.94563937
99Amyotrophic lateral sclerosis (HP:0007354)1.94520260
100Generalized myoclonic seizures (HP:0002123)1.90254558
101Aqueductal stenosis (HP:0002410)1.88726093
102Spinal canal stenosis (HP:0003416)1.86253415
103Obstructive sleep apnea (HP:0002870)1.85461664
104Rigidity (HP:0002063)1.85443128
105Termporal pattern (HP:0011008)1.83467596
106Insidious onset (HP:0003587)1.83467596
107Prolonged QT interval (HP:0001657)1.76697106
108Memory impairment (HP:0002354)1.74528814
109Lower limb amyotrophy (HP:0007210)1.74227732
110Slow progression (HP:0003677)1.71698911
111Split foot (HP:0001839)1.71506710
112Spastic tetraparesis (HP:0001285)1.71257097
113Spastic tetraplegia (HP:0002510)1.70469486
114Abnormality of the periventricular white matter (HP:0002518)1.67682464
115Aplasia of the phalanges of the hand (HP:0009802)1.66635635
116Aplasia involving bones of the extremities (HP:0009825)1.66635635
117Aplasia involving bones of the upper limbs (HP:0009823)1.66635635
118Morphological abnormality of the pyramidal tract (HP:0002062)1.66322400

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.05221198
2MAP3K93.93580297
3EPHA43.41613770
4MAP3K42.89519038
5MINK12.71053420
6MARK12.46346415
7PAK62.39966028
8NTRK22.32594451
9CAMKK12.31818961
10DAPK22.28044127
11MAP2K72.17780832
12PRKD32.05013461
13STK382.02503161
14KSR22.01952152
15CAMKK22.00886755
16MAP2K41.93789365
17RIPK41.81044008
18PRPF4B1.76932915
19NTRK11.76278701
20TNIK1.71787688
21CDK51.51521425
22RIPK11.51337482
23CDK191.49651641
24MAP3K121.48837121
25KSR11.40598092
26DAPK11.36281500
27PRKCG1.34544615
28WNK11.27082947
29MAP3K131.23310473
30MAPK131.23198539
31CAMK11.22249522
32GRK51.20855276
33TYRO31.17539835
34PRKCH1.12164051
35PNCK1.11319096
36FES1.10877999
37SGK4941.10530500
38SGK2231.10530500
39SIK21.09837856
40SGK21.08291031
41ALK1.02705061
42MAP3K21.02673947
43ARAF1.02547213
44SGK31.02289115
45PHKG11.01040817
46PHKG21.01040817
47TAOK10.99034226
48STK110.98920865
49PINK10.98082499
50PLK20.97023531
51LMTK20.96117917
52CAMK2A0.95151273
53UHMK10.93577041
54CDK150.90914557
55RET0.90520142
56CDK180.90327170
57CASK0.89392569
58CAMK2B0.86058956
59PDK10.85384709
60CDK140.79540731
61CDK11A0.78500991
62CAMK1G0.78247707
63SGK10.77559397
64MAPK120.76118121
65LATS20.76010687
66CCNB10.75997482
67CAMK40.75156802
68OXSR10.73602555
69PDPK10.73097473
70CDC42BPA0.72933370
71NEK60.72200485
72PTK2B0.69702831
73PKN10.68529858
74RAF10.67448254
75MARK20.66358877
76DYRK1A0.64532910
77TNK20.64190615
78PAK30.62103267
79MAP3K70.61030446
80RPS6KA30.60013985
81CAMK2G0.59589200
82DAPK30.56214821
83FGFR20.52948426
84CAMK2D0.52882628
85MAP3K10.51697488
86LIMK10.51169902
87FYN0.50511710
88MAPK100.47304210
89BMPR20.46398886
90MAP3K110.46012017
91MAPKAPK50.43803846
92PRKCZ0.42874714
93SCYL20.42723042
94BRAF0.42501491
95DMPK0.41776904
96NEK10.40585131
97CSNK1G20.39594960
98ROCK20.38123890
99FER0.36322826
100PRKG10.35777512
101PRKCB0.34973869
102PRKCA0.33138359
103TAOK20.30810240
104PRKCE0.30467645
105BRSK10.30224260
106MAPK80.29195688
107PRKACB0.29128385
108PRKACA0.28626237
109ERBB20.28394889
110CSNK1D0.27616424
111SRC0.27557296
112CAMK1D0.25688598
113GSK3B0.24582896
114CSNK1E0.24352379

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.99057498
2Synaptic vesicle cycle_Homo sapiens_hsa047213.04764672
3Long-term potentiation_Homo sapiens_hsa047202.83811112
4Circadian entrainment_Homo sapiens_hsa047132.80712497
5Glutamatergic synapse_Homo sapiens_hsa047242.77670199
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.70828702
7GABAergic synapse_Homo sapiens_hsa047272.69325972
8Olfactory transduction_Homo sapiens_hsa047402.46642217
9Morphine addiction_Homo sapiens_hsa050322.42681999
10Amphetamine addiction_Homo sapiens_hsa050312.38554759
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.33852691
12* Salivary secretion_Homo sapiens_hsa049702.24223569
13Insulin secretion_Homo sapiens_hsa049112.04940971
14Gastric acid secretion_Homo sapiens_hsa049712.04142032
15Aldosterone synthesis and secretion_Homo sapiens_hsa049252.03028918
16Dopaminergic synapse_Homo sapiens_hsa047281.99752448
17Long-term depression_Homo sapiens_hsa047301.91949868
18Taste transduction_Homo sapiens_hsa047421.85546108
19Cholinergic synapse_Homo sapiens_hsa047251.85258696
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.71780108
21Oxytocin signaling pathway_Homo sapiens_hsa049211.63676493
22* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63523263
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.62001251
24* Calcium signaling pathway_Homo sapiens_hsa040201.60186129
25Renin secretion_Homo sapiens_hsa049241.53950715
26GnRH signaling pathway_Homo sapiens_hsa049121.46265490
27Serotonergic synapse_Homo sapiens_hsa047261.45530098
28Cocaine addiction_Homo sapiens_hsa050301.45156219
29Nitrogen metabolism_Homo sapiens_hsa009101.44401747
30Type II diabetes mellitus_Homo sapiens_hsa049301.43874709
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.36993944
32* cAMP signaling pathway_Homo sapiens_hsa040241.31062670
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29303083
34Gap junction_Homo sapiens_hsa045401.27080464
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26716399
36Vitamin B6 metabolism_Homo sapiens_hsa007501.21944040
37Estrogen signaling pathway_Homo sapiens_hsa049151.21470673
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20190581
39Glioma_Homo sapiens_hsa052141.04451574
40* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01715403
41Thyroid hormone synthesis_Homo sapiens_hsa049181.00277166
42* Pancreatic secretion_Homo sapiens_hsa049720.97743100
43Phospholipase D signaling pathway_Homo sapiens_hsa040720.96531499
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95138160
45Melanogenesis_Homo sapiens_hsa049160.93662835
46ErbB signaling pathway_Homo sapiens_hsa040120.93121583
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.91813632
48Cardiac muscle contraction_Homo sapiens_hsa042600.90768752
49Collecting duct acid secretion_Homo sapiens_hsa049660.89539520
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87357782
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86164400
52Axon guidance_Homo sapiens_hsa043600.85898112
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84877849
54Oocyte meiosis_Homo sapiens_hsa041140.83861847
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82452404
56Dorso-ventral axis formation_Homo sapiens_hsa043200.82065679
57Bile secretion_Homo sapiens_hsa049760.79582358
58Dilated cardiomyopathy_Homo sapiens_hsa054140.79450134
59Choline metabolism in cancer_Homo sapiens_hsa052310.76730775
60MAPK signaling pathway_Homo sapiens_hsa040100.68634323
61Inositol phosphate metabolism_Homo sapiens_hsa005620.66106823
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.64984221
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60640415
64mTOR signaling pathway_Homo sapiens_hsa041500.59582879
65Glucagon signaling pathway_Homo sapiens_hsa049220.55882836
66VEGF signaling pathway_Homo sapiens_hsa043700.55509077
67Rap1 signaling pathway_Homo sapiens_hsa040150.52665773
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51964588
69Circadian rhythm_Homo sapiens_hsa047100.51955126
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51893217
71Vibrio cholerae infection_Homo sapiens_hsa051100.51424018
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48733074
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48140918
74Endocytosis_Homo sapiens_hsa041440.48077058
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.47962143
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46984029
77Ras signaling pathway_Homo sapiens_hsa040140.45879436
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44437453
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43014861
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42551851
81Ovarian steroidogenesis_Homo sapiens_hsa049130.42423456
82Non-small cell lung cancer_Homo sapiens_hsa052230.40163456
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38758925
84Phototransduction_Homo sapiens_hsa047440.37889430
85Alzheimers disease_Homo sapiens_hsa050100.37725842
86Mineral absorption_Homo sapiens_hsa049780.37474788
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37321412
88Endometrial cancer_Homo sapiens_hsa052130.36687970
89Prion diseases_Homo sapiens_hsa050200.36467797
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35553415
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34865532
92Fatty acid biosynthesis_Homo sapiens_hsa000610.34085643
93Insulin signaling pathway_Homo sapiens_hsa049100.33886753
94Alcoholism_Homo sapiens_hsa050340.33779625
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33644383
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.32916882
97Arginine and proline metabolism_Homo sapiens_hsa003300.32461149
98Type I diabetes mellitus_Homo sapiens_hsa049400.32334836
99Chemokine signaling pathway_Homo sapiens_hsa040620.32241750
100Wnt signaling pathway_Homo sapiens_hsa043100.30596697
101African trypanosomiasis_Homo sapiens_hsa051430.30306214
102Arginine biosynthesis_Homo sapiens_hsa002200.30272507
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30192916
104Renal cell carcinoma_Homo sapiens_hsa052110.27819592
105Platelet activation_Homo sapiens_hsa046110.27132160
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22285716
107Tight junction_Homo sapiens_hsa045300.21232565
108Histidine metabolism_Homo sapiens_hsa003400.20960827
109AMPK signaling pathway_Homo sapiens_hsa041520.20451267
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18483884
111beta-Alanine metabolism_Homo sapiens_hsa004100.15651186
112Hippo signaling pathway_Homo sapiens_hsa043900.15558776
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.14185247

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »