ATOH8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fibrinolysis (GO:0051918)5.45410002
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.39705762
3L-phenylalanine catabolic process (GO:0006559)5.39705762
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.28327987
5L-phenylalanine metabolic process (GO:0006558)5.28327987
6sperm motility (GO:0030317)4.94651226
7cell migration involved in heart development (GO:0060973)4.83922258
8regulation of fibrinolysis (GO:0051917)4.79593088
9aromatic amino acid family catabolic process (GO:0009074)4.68917682
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.61711686
11alpha-linolenic acid metabolic process (GO:0036109)4.57952734
12peptidyl-glutamic acid carboxylation (GO:0017187)4.50801424
13protein carboxylation (GO:0018214)4.50801424
14glyoxylate metabolic process (GO:0046487)4.49236483
15fusion of sperm to egg plasma membrane (GO:0007342)4.49111966
16fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.44421833
17urea cycle (GO:0000050)4.42671221
18urea metabolic process (GO:0019627)4.42671221
19epoxygenase P450 pathway (GO:0019373)4.38102966
20sulfur amino acid catabolic process (GO:0000098)4.37068923
21protein heterotrimerization (GO:0070208)4.32489790
22kynurenine metabolic process (GO:0070189)4.26009810
23regulation of protein activation cascade (GO:2000257)4.23776530
24bile acid biosynthetic process (GO:0006699)4.22665109
25indole-containing compound catabolic process (GO:0042436)4.07914962
26indolalkylamine catabolic process (GO:0046218)4.07914962
27tryptophan catabolic process (GO:0006569)4.07914962
28complement activation, alternative pathway (GO:0006957)4.06061634
29nitrogen cycle metabolic process (GO:0071941)4.04273321
30regulation of complement activation (GO:0030449)4.02164112
31sperm-egg recognition (GO:0035036)4.01011256
32high-density lipoprotein particle remodeling (GO:0034375)3.98255810
33cell wall macromolecule catabolic process (GO:0016998)3.96116142
34cell wall macromolecule metabolic process (GO:0044036)3.96116142
35cysteine metabolic process (GO:0006534)3.95774875
36regulation of triglyceride catabolic process (GO:0010896)3.89715936
37lysine catabolic process (GO:0006554)3.86801036
38lysine metabolic process (GO:0006553)3.86801036
39acrosome reaction (GO:0007340)3.83315043
40amino-acid betaine metabolic process (GO:0006577)3.82015885
41tryptophan metabolic process (GO:0006568)3.79962465
42binding of sperm to zona pellucida (GO:0007339)3.79692296
43regulation of plasminogen activation (GO:0010755)3.74395365
44positive regulation of fatty acid beta-oxidation (GO:0032000)3.68065384
45homocysteine metabolic process (GO:0050667)3.66776211
46acrosome assembly (GO:0001675)3.65671350
47extracellular matrix assembly (GO:0085029)3.63164043
48plasma lipoprotein particle clearance (GO:0034381)3.61709782
49fibrinolysis (GO:0042730)3.59713853
50serine family amino acid catabolic process (GO:0009071)3.57470676
51muscle cell fate commitment (GO:0042693)3.55667158
52cell-cell recognition (GO:0009988)3.55446687
53collagen fibril organization (GO:0030199)3.51582795
54regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.48651240
55bile acid metabolic process (GO:0008206)3.47159648
56negative regulation of cholesterol transport (GO:0032375)3.46433308
57negative regulation of sterol transport (GO:0032372)3.46433308
58positive regulation of osteoblast proliferation (GO:0033690)3.46211205
59reverse cholesterol transport (GO:0043691)3.44765675
60triglyceride homeostasis (GO:0070328)3.44683861
61acylglycerol homeostasis (GO:0055090)3.44683861
62dermatan sulfate biosynthetic process (GO:0030208)3.43743616
63regulation of fatty acid beta-oxidation (GO:0031998)3.43715279
64actin-myosin filament sliding (GO:0033275)3.42888571
65muscle filament sliding (GO:0030049)3.42888571
66peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.41570497
67coenzyme catabolic process (GO:0009109)3.39470808
68plasma membrane fusion (GO:0045026)3.37140186
69dermatan sulfate metabolic process (GO:0030205)3.31164806
70virion attachment to host cell (GO:0019062)3.30953796
71adhesion of symbiont to host cell (GO:0044650)3.30953796
72plasma lipoprotein particle remodeling (GO:0034369)3.29541423
73protein-lipid complex remodeling (GO:0034368)3.29541423
74macromolecular complex remodeling (GO:0034367)3.29541423
75venous blood vessel morphogenesis (GO:0048845)3.28111847
76cellular glucuronidation (GO:0052695)3.26912658
77cardiac myofibril assembly (GO:0055003)3.26468051
78alpha-amino acid catabolic process (GO:1901606)3.26420410
79positive regulation of lipid catabolic process (GO:0050996)3.26378479
80tyrosine metabolic process (GO:0006570)3.25943148
81barbed-end actin filament capping (GO:0051016)3.25782534
82aromatic amino acid family metabolic process (GO:0009072)3.24418902
83organic cation transport (GO:0015695)3.22604351
84regulation of cholesterol esterification (GO:0010872)3.22134230
854-hydroxyproline metabolic process (GO:0019471)3.21682884
86multicellular organism reproduction (GO:0032504)3.21571789
87aspartate family amino acid catabolic process (GO:0009068)3.19868020
88actin-mediated cell contraction (GO:0070252)3.17282652
89positive regulation of triglyceride lipase activity (GO:0061365)3.15814057
90positive regulation of lipoprotein lipase activity (GO:0051006)3.15814057
91positive regulation of fatty acid oxidation (GO:0046321)3.15240473
92extracellular fibril organization (GO:0043206)3.12008883
93cellular modified amino acid catabolic process (GO:0042219)3.11678948
94carnitine metabolic process (GO:0009437)3.08382282
95endodermal cell differentiation (GO:0035987)3.05809014
96cellular amino acid catabolic process (GO:0009063)3.04513091
97endothelial cell morphogenesis (GO:0001886)3.03621383
98response to mercury ion (GO:0046689)3.02082709
99atrioventricular valve morphogenesis (GO:0003181)2.99980301
100vascular endothelial growth factor signaling pathway (GO:0038084)2.99465533
101arginine metabolic process (GO:0006525)2.99345567
102spermatid development (GO:0007286)2.98052703
103sarcomere organization (GO:0045214)2.97475345
104glycine metabolic process (GO:0006544)2.96535946
1052-oxoglutarate metabolic process (GO:0006103)2.95438419
106reproduction (GO:0000003)2.95239103
107ethanol oxidation (GO:0006069)2.95231114
108cofactor catabolic process (GO:0051187)2.94043862
109midgut development (GO:0007494)2.93643771
110regulation of cholesterol homeostasis (GO:2000188)2.93285299
111regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.93122589
112retina vasculature morphogenesis in camera-type eye (GO:0061299)2.92096436
113myofibril assembly (GO:0030239)2.91464103
114fatty acid beta-oxidation (GO:0006635)2.89643898
115basement membrane organization (GO:0071711)2.89629545
116benzene-containing compound metabolic process (GO:0042537)2.89321846
117phospholipid efflux (GO:0033700)2.87989380
118adhesion of symbiont to host (GO:0044406)2.87797589
119kidney mesenchyme development (GO:0072074)2.87736884
120negative regulation of protein activation cascade (GO:2000258)2.86974371
121bile acid and bile salt transport (GO:0015721)2.86956316
122serine family amino acid metabolic process (GO:0009069)2.86298388
123cholesterol homeostasis (GO:0042632)2.86108635
124negative regulation of myoblast differentiation (GO:0045662)2.85796054
125cilium or flagellum-dependent cell motility (GO:0001539)2.84095345
126negative regulation of smooth muscle cell migration (GO:0014912)2.84050803
127neuron projection extension involved in neuron projection guidance (GO:1902284)2.84026430
128axon extension involved in axon guidance (GO:0048846)2.84026430
129serine family amino acid biosynthetic process (GO:0009070)2.83256460
130lymphangiogenesis (GO:0001946)2.83031032
131glomerular basement membrane development (GO:0032836)2.83016079
132negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.82732421
133regulation of fatty acid oxidation (GO:0046320)2.82189871
134sterol homeostasis (GO:0055092)2.80971952
135uronic acid metabolic process (GO:0006063)2.80587024
136glucuronate metabolic process (GO:0019585)2.80587024
137negative regulation of catenin import into nucleus (GO:0035414)2.77914674
138paraxial mesoderm development (GO:0048339)2.77486478
139endocardial cushion morphogenesis (GO:0003203)2.75546283
140vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.73092037
141adherens junction assembly (GO:0034333)2.71721837
142fibril organization (GO:0097435)2.71516766
143regulation of integrin-mediated signaling pathway (GO:2001044)2.69496870
144blood vessel maturation (GO:0001955)2.67636560
145metanephric mesenchyme development (GO:0072075)2.66214778
146cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.63532241
147negative regulation of protein localization to cell surface (GO:2000009)2.63186768
148peripheral nervous system axon ensheathment (GO:0032292)2.61572087
149myelination in peripheral nervous system (GO:0022011)2.61572087
150positive regulation of blood vessel endothelial cell migration (GO:0043536)2.60649798
151chondrocyte proliferation (GO:0035988)2.59471014
152actin filament-based movement (GO:0030048)2.58615391
153chondroitin sulfate catabolic process (GO:0030207)2.58535055
154actomyosin structure organization (GO:0031032)2.58434962
155mesenchyme morphogenesis (GO:0072132)2.58330199
156cell-substrate junction assembly (GO:0007044)2.58175939
157response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.57538764
158cellular response to epinephrine stimulus (GO:0071872)2.56921535
159positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.56695808
160stress fiber assembly (GO:0043149)2.55612035
161bone trabecula formation (GO:0060346)2.55453920
162collagen metabolic process (GO:0032963)2.54378941
163planar cell polarity pathway involved in neural tube closure (GO:0090179)2.52657440
164negative regulation of BMP signaling pathway (GO:0030514)2.52042657
165sequestering of extracellular ligand from receptor (GO:0035581)2.50430235
166positive regulation of receptor recycling (GO:0001921)2.49943087
167negative regulation of chondrocyte differentiation (GO:0032331)2.48283518
168positive regulation of myotube differentiation (GO:0010831)2.48158232
169focal adhesion assembly (GO:0048041)2.46743215
170cell-substrate adherens junction assembly (GO:0007045)2.46743215
171endocardial cushion development (GO:0003197)2.46234549
172cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.45255681
173regulation of myoblast differentiation (GO:0045661)2.44672456
174enteric nervous system development (GO:0048484)2.44372639
175regulation of glucose import in response to insulin stimulus (GO:2001273)2.44370187
176regulation of p38MAPK cascade (GO:1900744)2.43729027
177fibroblast migration (GO:0010761)2.42948105
178skeletal muscle fiber development (GO:0048741)2.42946737
179regulation of osteoblast proliferation (GO:0033688)2.42581688
180heart trabecula formation (GO:0060347)2.42239352
181chondroitin sulfate biosynthetic process (GO:0030206)2.40853549
182skin morphogenesis (GO:0043589)2.40644458
183type B pancreatic cell proliferation (GO:0044342)2.39211144
184artery morphogenesis (GO:0048844)2.38401289
185negative regulation of fatty acid transport (GO:2000192)2.37740014
186multicellular organismal macromolecule metabolic process (GO:0044259)2.36880231
187neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.36634638
188metanephric nephron epithelium development (GO:0072243)2.35463670
189apoptotic cell clearance (GO:0043277)2.34547850
190pericardium development (GO:0060039)2.34363568
191trabecula formation (GO:0060343)2.33598635
192positive regulation of cartilage development (GO:0061036)2.30747387
193response to inactivity (GO:0014854)2.30517140
194regulation of the force of heart contraction (GO:0002026)2.29972421
195blood vessel morphogenesis (GO:0048514)2.29948822
196regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.29940331
197middle ear morphogenesis (GO:0042474)2.29732114
198response to epinephrine (GO:0071871)2.29252814

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.51829776
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.93495639
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.27579036
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.91730062
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.42547431
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.15343440
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.69110514
8RARG_19884340_ChIP-ChIP_MEFs_Mouse3.59062605
9* FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.51293087
10TRIM28_21343339_ChIP-Seq_HEK293_Human3.22796928
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.80047537
12* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.79756318
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.61470161
14CLOCK_20551151_ChIP-Seq_293T_Human2.53673481
15* EED_16625203_ChIP-ChIP_MESCs_Mouse2.29866876
16* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.27596669
17* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.27596669
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17587376
19* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15991703
20* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11059156
21ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.04273750
22EZH2_22144423_ChIP-Seq_EOC_Human2.00206647
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.97314849
24CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.97006246
25* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.96349625
26* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95348516
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.95018247
28* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.94005313
29* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.90743199
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.88040544
31* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.87764663
32* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.83045473
33RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.79211969
34* RNF2_27304074_Chip-Seq_ESCs_Mouse1.76121877
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.74589719
36* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73451208
37TP53_20018659_ChIP-ChIP_R1E_Mouse1.71596492
38* EZH2_27304074_Chip-Seq_ESCs_Mouse1.65037231
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.62458562
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.62221013
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.60302173
42EP300_21415370_ChIP-Seq_HL-1_Mouse1.58824916
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.53558084
44* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53073753
45* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.52849050
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.51502338
47TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.51206753
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50091542
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48274397
50* TBX20_22080862_ChIP-Seq_HEART_Mouse1.48109154
51* TBX20_22328084_ChIP-Seq_HEART_Mouse1.48109154
52* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47722785
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46408584
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.46139604
55TP63_17297297_ChIP-ChIP_HaCaT_Human1.45015694
56* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42252891
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.41417113
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39661256
59KDM2B_26808549_Chip-Seq_K562_Human1.38243401
60FOXA2_19822575_ChIP-Seq_HepG2_Human1.37408635
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34740253
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34203541
63* CJUN_26792858_Chip-Seq_BT549_Human1.32103714
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.31746890
65RXRA_24833708_ChIP-Seq_LIVER_Mouse1.30977517
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30803988
67ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27155819
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25029764
69* ISL1_27105846_Chip-Seq_CPCs_Mouse1.24576925
70P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23926898
71* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22607394
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20947489
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20802191
74* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.20744264
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20682627
76* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18019078
77* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17692087
78ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17448751
79RING1B_27294783_Chip-Seq_NPCs_Mouse1.17252708
80RAD21_21589869_ChIP-Seq_MESCs_Mouse1.16047200
81HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12914539
82* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12633828
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11095750
84* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09691483
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.08597395
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07825103
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05445261
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05329502
89TP53_18474530_ChIP-ChIP_U2OS_Human1.04402763
90EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04060258
91ESR2_21235772_ChIP-Seq_MCF-7_Human1.03847143
92TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02559579
93* HNF4A_19822575_ChIP-Seq_HepG2_Human1.01897465
94PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01519931
95LXR_22292898_ChIP-Seq_THP-1_Human1.00211711
96JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99699872
97RARA_24833708_ChIP-Seq_LIVER_Mouse0.98707510
98* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96963452
99ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96869461
100CSB_26484114_Chip-Seq_FIBROBLAST_Human0.95993196
101PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95716469
102UBF1/2_26484160_Chip-Seq_HMECs_Human0.94598358
103CBX2_27304074_Chip-Seq_ESCs_Mouse0.93855892
104* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93373917
105DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92823165
106DROSHA_22980978_ChIP-Seq_HELA_Human0.91581783
107* MYC_27129775_Chip-Seq_CORNEA_Mouse0.91151142
108TP53_22127205_ChIP-Seq_IMR90_Human0.90396853
109KDM2B_26808549_Chip-Seq_DND41_Human0.90085832
110* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88923695
111ELK3_25401928_ChIP-Seq_HUVEC_Human0.88560233
112SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87893566
113EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.86925603
114* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85733443
115NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85165129
116NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85165129
117HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85143054
118SA1_22415368_ChIP-Seq_MEFs_Mouse0.84359905
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83759231
120LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.83654906
121* P53_21459846_ChIP-Seq_SAOS-2_Human0.83360091
122EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.82128420
123TET1_21451524_ChIP-Seq_MESCs_Mouse0.82093560
124NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.81962076
125BRD4_25478319_ChIP-Seq_HGPS_Human0.81623143
126* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.81265598
127ESR1_21235772_ChIP-Seq_MCF-7_Human0.80546331
128STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80476098
129* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.80433021
130GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.77353052
131ZNF263_19887448_ChIP-Seq_K562_Human0.76695116
132* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75645161
133ATF3_27146783_Chip-Seq_COLON_Human0.75142323
134SOX9_24532713_ChIP-Seq_HFSC_Mouse0.75126310
135FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74741701
136RARB_24833708_ChIP-Seq_LIVER_Mouse0.73647258
137RACK7_27058665_Chip-Seq_MCF-7_Human0.73031106
138JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72608085
139ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72391744
140ELK4_26923725_Chip-Seq_MESODERM_Mouse0.72004247
141ZNF274_21170338_ChIP-Seq_K562_Hela0.70476589
142TP63_22573176_ChIP-Seq_HFKS_Human0.70149113
143* STAT1_17558387_ChIP-Seq_HELA_Human0.69772656
144GATA4_25053715_ChIP-Seq_YYC3_Human0.69258777
145MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.68332544
146CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68329470
147FOXO3_23340844_ChIP-Seq_DLD1_Human0.68162960
148NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.67368700
149EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.67367133
150FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.66823248
151AUTS2_25519132_ChIP-Seq_293T-REX_Human0.66405276
152ELF1_20517297_ChIP-Seq_JURKAT_Human0.65226475
153TP53_23651856_ChIP-Seq_MEFs_Mouse0.63776268
154SMC4_20622854_ChIP-Seq_HELA_Human0.63353383
155CTCF_27219007_Chip-Seq_Bcells_Human0.63282587
156BCAT_22108803_ChIP-Seq_LS180_Human0.63186849

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.33679367
2MP0005360_urolithiasis4.83734792
3MP0005410_abnormal_fertilization4.16684537
4MP0005365_abnormal_bile_salt3.96014879
5MP0005085_abnormal_gallbladder_physiolo3.95835201
6MP0008438_abnormal_cutaneous_collagen3.95684725
7MP0003705_abnormal_hypodermis_morpholog3.79678095
8MP0008875_abnormal_xenobiotic_pharmacok3.03615753
9MP0003252_abnormal_bile_duct3.01199587
10MP0005503_abnormal_tendon_morphology2.82353624
11MP0003806_abnormal_nucleotide_metabolis2.80144647
12MP0003279_aneurysm2.75600386
13MP0005275_abnormal_skin_tensile2.34205221
14MP0010368_abnormal_lymphatic_system2.25674821
15MP0010329_abnormal_lipoprotein_level2.18961284
16MP0005083_abnormal_biliary_tract2.05074777
17MP0009384_cardiac_valve_regurgitation2.02868257
18MP0005670_abnormal_white_adipose1.89276603
19MP0003950_abnormal_plasma_membrane1.89069494
20MP0009840_abnormal_foam_cell1.78316807
21MP0009053_abnormal_anal_canal1.72973172
22MP0005332_abnormal_amino_acid1.72518519
23MP0009780_abnormal_chondrocyte_physiolo1.71501886
24MP0005623_abnormal_meninges_morphology1.67224227
25MP0004272_abnormal_basement_membrane1.64251976
26MP0005171_absent_coat_pigmentation1.60730123
27MP0002837_dystrophic_cardiac_calcinosis1.58097365
28MP0001958_emphysema1.53050100
29MP0003195_calcinosis1.51781126
30MP0002282_abnormal_trachea_morphology1.48514646
31MP0001666_abnormal_nutrient_absorption1.40393750
32MP0001299_abnormal_eye_distance/1.37732346
33MP0000747_muscle_weakness1.37124108
34MP0003828_pulmonary_edema1.36781367
35MP0010030_abnormal_orbit_morphology1.36304014
36MP0002295_abnormal_pulmonary_circulatio1.35779158
37MP0000003_abnormal_adipose_tissue1.32918852
38MP0005620_abnormal_muscle_contractility1.32443514
39MP0005023_abnormal_wound_healing1.31895655
40MP0005369_muscle_phenotype1.29541500
41MP0000609_abnormal_liver_physiology1.28795575
42MP0005319_abnormal_enzyme/_coenzyme1.27242902
43MP0002118_abnormal_lipid_homeostasis1.25127626
44MP0002106_abnormal_muscle_physiology1.18891288
45MP0004858_abnormal_nervous_system1.18277272
46MP0002972_abnormal_cardiac_muscle1.17420097
47MP0005375_adipose_tissue_phenotype1.16262961
48MP0003115_abnormal_respiratory_system1.15322017
49MP0002108_abnormal_muscle_morphology1.15174021
50MP0006054_spinal_hemorrhage1.12151734
51MP0000767_abnormal_smooth_muscle1.10068009
52MP0003698_abnormal_male_reproductive1.08457545
53MP0001879_abnormal_lymphatic_vessel1.07100810
54MP0000681_abnormal_thyroid_gland1.06477360
55MP0003191_abnormal_cellular_cholesterol1.05825856
56MP0004145_abnormal_muscle_electrophysio1.03387506
57MP0003566_abnormal_cell_adhesion1.01857208
58MP0004019_abnormal_vitamin_homeostasis1.01392181
59MP0005508_abnormal_skeleton_morphology1.01116930
60MP0004084_abnormal_cardiac_muscle0.99040499
61MP0000049_abnormal_middle_ear0.98995433
62MP0004215_abnormal_myocardial_fiber0.98483905
63MP0002138_abnormal_hepatobiliary_system0.97257248
64MP0001929_abnormal_gametogenesis0.96372647
65MP0002060_abnormal_skin_morphology0.94905025
66MP0003011_delayed_dark_adaptation0.94379088
67MP0003385_abnormal_body_wall0.93336920
68MP0005388_respiratory_system_phenotype0.91953333
69MP0002133_abnormal_respiratory_system0.91953333
70MP0000343_altered_response_to0.90949094
71MP0009250_abnormal_appendicular_skeleto0.90741844
72MP0003868_abnormal_feces_composition0.90477859
73MP0001243_abnormal_dermal_layer0.90327409
74MP0001661_extended_life_span0.89604794
75MP0000733_abnormal_muscle_development0.89406324
76MP0002269_muscular_atrophy0.89127432
77MP0003942_abnormal_urinary_system0.88042929
78MP0000749_muscle_degeneration0.87613566
79MP0000598_abnormal_liver_morphology0.87495615
80MP0006138_congestive_heart_failure0.86481537
81MP0002127_abnormal_cardiovascular_syste0.86317381
82MP0005647_abnormal_sex_gland0.85726199
83MP0003091_abnormal_cell_migration0.85303808
84MP0009697_abnormal_copulation0.85264719
85MP0004087_abnormal_muscle_fiber0.84882005
86MP0002128_abnormal_blood_circulation0.82960249
87MP0005257_abnormal_intraocular_pressure0.82901026
88MP0000751_myopathy0.82645063
89MP0005330_cardiomyopathy0.82456340
90MP0005666_abnormal_adipose_tissue0.80861366
91MP0002168_other_aberrant_phenotype0.80727374
92MP0004233_abnormal_muscle_weight0.80505624
93MP0002877_abnormal_melanocyte_morpholog0.79839723
94MP0002249_abnormal_larynx_morphology0.79720708
95MP0000750_abnormal_muscle_regeneration0.79621969
96MP0000762_abnormal_tongue_morphology0.79428913
97MP0005197_abnormal_uvea_morphology0.79125420
98MP0002932_abnormal_joint_morphology0.78795168
99MP0000462_abnormal_digestive_system0.77634451
100MP0000534_abnormal_ureter_morphology0.76859808
101MP0005584_abnormal_enzyme/coenzyme_acti0.76753569
102MP0003137_abnormal_impulse_conducting0.76633385
103MP0001542_abnormal_bone_strength0.76111076
104MP0000013_abnormal_adipose_tissue0.75439149
105MP0004510_myositis0.74637894
106MP0002332_abnormal_exercise_endurance0.74453977
107MP0005084_abnormal_gallbladder_morpholo0.74001122
108MP0010630_abnormal_cardiac_muscle0.73608028
109MP0002933_joint_inflammation0.73065054
110MP0009643_abnormal_urine_homeostasis0.71642659
111MP0000428_abnormal_craniofacial_morphol0.71470022
112MP0004036_abnormal_muscle_relaxation0.71204584
113MP0005165_increased_susceptibility_to0.71182140
114MP0003959_abnormal_lean_body0.70531272
115MP0002115_abnormal_skeleton_extremities0.70395407
116MP0004130_abnormal_muscle_cell0.69968255
117MP0003634_abnormal_glial_cell0.69893574
118MP0005595_abnormal_vascular_smooth0.68724982
119MP0002971_abnormal_brown_adipose0.68490509
120MP0005409_darkened_coat_color0.68479677
121MP0010386_abnormal_urinary_bladder0.67940332
122MP0003646_muscle_fatigue0.66510876
123MP0002896_abnormal_bone_mineralization0.65697732
124MP0002161_abnormal_fertility/fecundity0.64941211
125MP0008775_abnormal_heart_ventricle0.64798328
126MP0005385_cardiovascular_system_phenoty0.64725258
127MP0001544_abnormal_cardiovascular_syste0.64725258
128MP0005220_abnormal_exocrine_pancreas0.64329096
129MP0003186_abnormal_redox_activity0.63812069
130MP0000163_abnormal_cartilage_morphology0.63706437
131MP0005167_abnormal_blood-brain_barrier0.63539327
132MP0000249_abnormal_blood_vessel0.63169755
133MP0002116_abnormal_craniofacial_bone0.62386935
134MP0003283_abnormal_digestive_organ0.62275688
135MP0000537_abnormal_urethra_morphology0.62137325
136MP0005451_abnormal_body_composition0.61741435
137MP0001915_intracranial_hemorrhage0.61670640
138MP0001764_abnormal_homeostasis0.61450607
139MP0000759_abnormal_skeletal_muscle0.60056213
140MP0005248_abnormal_Harderian_gland0.59422108
141MP0001614_abnormal_blood_vessel0.58900641

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.67250291
2Protrusio acetabuli (HP:0003179)5.59416953
3Premature rupture of membranes (HP:0001788)4.69439279
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.39291319
5Xanthomatosis (HP:0000991)4.36954202
6Intrahepatic cholestasis (HP:0001406)4.36420294
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.34231280
8Hypobetalipoproteinemia (HP:0003563)4.05506735
9Vascular tortuosity (HP:0004948)3.98998327
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.84267453
11Prolonged partial thromboplastin time (HP:0003645)3.83195571
12Hypoalphalipoproteinemia (HP:0003233)3.63561219
13Dynein arm defect of respiratory motile cilia (HP:0012255)3.62460474
14Absent/shortened dynein arms (HP:0200106)3.62460474
15Hyperlipoproteinemia (HP:0010980)3.58463345
16Complement deficiency (HP:0004431)3.57016098
17Hypolipoproteinemia (HP:0010981)3.56009891
18Arterial tortuosity (HP:0005116)3.50316785
19Peritonitis (HP:0002586)3.48518341
20Round ear (HP:0100830)3.26542500
21Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.25581536
22Abnormality of skeletal muscle fiber size (HP:0012084)3.21763137
23Muscle fiber inclusion bodies (HP:0100299)3.15444991
24Aortic aneurysm (HP:0004942)3.14014711
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.11193362
26Nemaline bodies (HP:0003798)3.05785480
27Abnormality of the intrinsic pathway (HP:0010989)3.00487816
28Abnormality of the common coagulation pathway (HP:0010990)2.93933846
29Ketosis (HP:0001946)2.90582315
30Abnormality of dentin (HP:0010299)2.89628342
31Mildly elevated creatine phosphokinase (HP:0008180)2.88449657
32Abnormality of complement system (HP:0005339)2.87792940
33Hyperammonemia (HP:0001987)2.87050474
34Epidermoid cyst (HP:0200040)2.77445453
35Aortic dissection (HP:0002647)2.76492376
36Increased connective tissue (HP:0009025)2.74757391
37Hypercholesterolemia (HP:0003124)2.74216481
38Abnormality of glutamine family amino acid metabolism (HP:0010902)2.73979419
39Wrist flexion contracture (HP:0001239)2.72863999
40Ulnar bowing (HP:0003031)2.70007808
41Biconcave vertebral bodies (HP:0004586)2.67972024
42Shallow orbits (HP:0000586)2.66981662
43Distal lower limb muscle weakness (HP:0009053)2.65582373
44Spinal rigidity (HP:0003306)2.64462891
45Neonatal short-limb short stature (HP:0008921)2.64424784
46Slender build (HP:0001533)2.63832431
47Mitral regurgitation (HP:0001653)2.63714432
48Cardiovascular calcification (HP:0011915)2.59916508
49Abnormality of sulfur amino acid metabolism (HP:0004339)2.59641510
50Broad metatarsal (HP:0001783)2.54874165
51Cervical subluxation (HP:0003308)2.52096852
52Myocardial infarction (HP:0001658)2.50747265
53Ankle contracture (HP:0006466)2.48283831
54Type 1 muscle fiber predominance (HP:0003803)2.47845041
55Nasal polyposis (HP:0100582)2.47843445
56Joint hemorrhage (HP:0005261)2.47757065
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.47169175
58Aortic regurgitation (HP:0001659)2.44601476
59Wide anterior fontanel (HP:0000260)2.44351333
60Abnormality of methionine metabolism (HP:0010901)2.43079656
61Abnormality of the nasal mucosa (HP:0000433)2.42695789
62Bladder diverticulum (HP:0000015)2.41448408
63Back pain (HP:0003418)2.37605651
64Right ventricular cardiomyopathy (HP:0011663)2.35920262
65Abnormality of the calf musculature (HP:0001430)2.35689796
66Abnormal respiratory motile cilium physiology (HP:0012261)2.33199488
67Fat malabsorption (HP:0002630)2.32098479
68Follicular hyperkeratosis (HP:0007502)2.31861941
69Hypoglycemic coma (HP:0001325)2.30984693
70Abnormal gallbladder physiology (HP:0012438)2.29205749
71Cholecystitis (HP:0001082)2.29205749
72Skin nodule (HP:0200036)2.29033679
73Cerebral aneurysm (HP:0004944)2.28658945
74Mitral stenosis (HP:0001718)2.27461459
75Vascular calcification (HP:0004934)2.27077696
76Abnormal delivery (HP:0001787)2.25873941
77Asymmetric septal hypertrophy (HP:0001670)2.25217455
78Bowel diverticulosis (HP:0005222)2.24827755
79Lipoatrophy (HP:0100578)2.24693888
80Chronic bronchitis (HP:0004469)2.24011805
81Hypoplasia of the iris (HP:0007676)2.23940634
82Blue sclerae (HP:0000592)2.22999994
83Hyporeflexia of lower limbs (HP:0002600)2.21744508
84Soft skin (HP:0000977)2.21673838
85Infertility (HP:0000789)2.21277354
86Hemorrhage of the eye (HP:0011885)2.19386849
87Ectopia lentis (HP:0001083)2.18936472
88Hyperextensible skin (HP:0000974)2.17579552
89Hepatocellular carcinoma (HP:0001402)2.17150878
90Exercise-induced myalgia (HP:0003738)2.14769321
91Spontaneous abortion (HP:0005268)2.14350398
92Dilatation of the ascending aorta (HP:0005111)2.14208064
93Genu recurvatum (HP:0002816)2.13885920
94Hyperglycinemia (HP:0002154)2.13864486
95Abnormality of fatty-acid metabolism (HP:0004359)2.13809644
96Myoglobinuria (HP:0002913)2.13499833
97Hypoventilation (HP:0002791)2.13338394
98Distal lower limb amyotrophy (HP:0008944)2.11928527
99Joint laxity (HP:0001388)2.10227903
100Mitral valve prolapse (HP:0001634)2.09596899
101Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.09561894
102Neck muscle weakness (HP:0000467)2.09178763
103Abnormal cartilage morphology (HP:0002763)2.08502044
104Vertebral compression fractures (HP:0002953)2.08383600
105Thin ribs (HP:0000883)2.07503516
106Camptodactyly of toe (HP:0001836)2.05835729
107Scapular winging (HP:0003691)2.05495517
108Venous abnormality (HP:0002624)2.05387072
109Elbow flexion contracture (HP:0002987)2.05145286
110Difficulty climbing stairs (HP:0003551)2.04891026
111Joint stiffness (HP:0001387)2.04109700
112Aneurysm (HP:0002617)2.03897405
113Aortic valve stenosis (HP:0001650)2.03833909
114Abnormality of serine family amino acid metabolism (HP:0010894)2.03449401
115Abnormality of glycine metabolism (HP:0010895)2.03449401
116Hyperglycinuria (HP:0003108)2.03009277
117Abnormality of the Achilles tendon (HP:0005109)2.02426037
118Abnormal respiratory motile cilium morphology (HP:0005938)2.01573359
119Abnormal respiratory epithelium morphology (HP:0012253)2.01573359
120Coronal craniosynostosis (HP:0004440)2.00766525
121Short nail (HP:0001799)2.00718016
122Generalized amyotrophy (HP:0003700)1.99470527
123Pulmonary artery stenosis (HP:0004415)1.98976031
124Nonimmune hydrops fetalis (HP:0001790)1.97739429
125Atrophic scars (HP:0001075)1.97070468
126EMG: myopathic abnormalities (HP:0003458)1.96029559
127Ulnar deviation of the wrist (HP:0003049)1.95776997
128Limited hip movement (HP:0008800)1.95618798
129Aplasia of the musculature (HP:0100854)1.94788723
130Sudden death (HP:0001699)1.94722278
131Myotonia (HP:0002486)1.92431312
132Spondylolisthesis (HP:0003302)1.92211976
133Bradycardia (HP:0001662)1.91612501
134Mild short stature (HP:0003502)1.90977540
135Bell-shaped thorax (HP:0001591)1.90905924
136Hip contracture (HP:0003273)1.90441018
137Increased variability in muscle fiber diameter (HP:0003557)1.89112993
138Cholelithiasis (HP:0001081)1.88418322
139Osteolytic defects of the hand bones (HP:0009699)1.88240197
140Osteolytic defects of the phalanges of the hand (HP:0009771)1.88240197
141Wormian bones (HP:0002645)1.88231891
142Rhinitis (HP:0012384)1.87612771
143Calcaneovalgus deformity (HP:0001848)1.87324820
144Lymphangioma (HP:0100764)1.86539663
145Infantile muscular hypotonia (HP:0008947)1.85904546
146Fragile skin (HP:0001030)1.83837860
147Turricephaly (HP:0000262)1.82155068
148Abnormality of pyrimidine metabolism (HP:0004353)1.82057750
149Rhabdomyolysis (HP:0003201)1.81090604
150Bundle branch block (HP:0011710)1.79468016
151Stroke (HP:0001297)1.79321415
152Ketoacidosis (HP:0001993)1.78975475
153Bulbar palsy (HP:0001283)1.78737956
154Abnormal gallbladder morphology (HP:0012437)1.78450022
155Hyperacusis (HP:0010780)1.78262958
156Centrally nucleated skeletal muscle fibers (HP:0003687)1.77242166
157Venous insufficiency (HP:0005293)1.76502243
158Long toe (HP:0010511)1.76152684
159Abnormality of the acetabulum (HP:0003170)1.75961855
160Limb-girdle muscle weakness (HP:0003325)1.75932965
161Difficulty running (HP:0009046)1.75555075
162Deformed tarsal bones (HP:0008119)1.75229637
163Muscle fiber splitting (HP:0003555)1.74331149
164Overgrowth (HP:0001548)1.74063444
165Atrial fibrillation (HP:0005110)1.73511961

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK34.41590591
2PDK44.41590591
3TESK14.22553650
4TRIB33.78173834
5ERN13.62074229
6PDK23.06096698
7BCKDK2.99135719
8LATS22.78112322
9TTN2.74772062
10PRKD32.59034148
11ICK2.58964270
12PKN22.36213121
13NTRK12.28275113
14PTK2B2.19811283
15SIK12.18928746
16MUSK2.15745670
17LATS11.98586065
18FGFR41.82082809
19PDGFRA1.77584428
20EPHB21.72701861
21AKT31.70137140
22DDR21.61344965
23DYRK1B1.55258250
24PTK61.50559483
25PAK21.47978105
26STK38L1.46535669
27MYLK1.41789364
28MAP3K101.38084097
29PIK3CG1.36679058
30CDC42BPA1.36299579
31KDR1.35070425
32MAP3K61.29903341
33MARK11.27408155
34PRKD21.20377728
35RIPK11.19613257
36NEK91.11928907
37PTK21.11321600
38ROCK21.04938512
39MAPK71.04624317
40STK31.02427294
41MTOR0.98402179
42MAP3K30.97551883
43PAK60.97388789
44PRPF4B0.96211198
45MARK20.95584036
46BMX0.94370675
47STK380.91621974
48PAK30.91392931
49FER0.89975398
50TIE10.89703359
51ERBB40.86861776
52WNK40.85807968
53FRK0.85798815
54CAMK2G0.85622662
55PAK40.84640411
56EEF2K0.84305649
57RPS6KA20.82597332
58TGFBR20.82041017
59MET0.79490328
60RPS6KA40.79373608
61LRRK20.79028794
62OBSCN0.78670922
63MELK0.77020562
64MAP2K30.74122302
65TGFBR10.72649020
66TESK20.72448016
67MOS0.68094328
68ROCK10.65807878
69EPHB10.65566688
70MAPK40.65505084
71EPHA30.65123686
72ABL20.63857339
73CAMK2D0.62063373
74MAP2K10.61167279
75LMTK20.60845203
76AKT20.60017278
77CDK60.59630237
78KSR20.59543676
79MAPK150.58419973
80LIMK10.58103212
81ADRBK10.55655678
82UHMK10.55325054
83ILK0.54770046
84RPS6KL10.54256085
85RPS6KC10.54256085
86PKN10.53385084
87NEK20.52289035
88FGFR10.51829177
89CAMK2B0.51733260
90MAPK110.51088982
91FGFR20.50104472
92ERBB20.50005147
93PIK3CA0.49716325
94FLT30.49548642
95DMPK0.49074202
96PDGFRB0.48685393
97PRKD10.47038639
98GRK50.44255081
99CAMK10.42832009
100SGK30.42366703
101PAK10.42314864
102PRKAA20.40538189
103MST1R0.40506118
104PDPK10.40322953
105CDK80.40312866
106ARAF0.39825405
107SMG10.38215992
108MAPKAPK30.37529961
109RPS6KA60.36317634
110CAMK1D0.35480255
111CAMK1G0.33878683
112DAPK30.33394772
113PRKG10.32958506
114SGK2230.32599090
115SGK4940.32599090
116TRPM70.32255977
117TBK10.32086145
118GSK3A0.31682045
119PRKCZ0.30537230
120PRKAA10.30352172
121PDK10.30327115
122MAPK120.30175925
123RET0.29523119
124MAP3K70.28635568
125PRKG20.27267141
126TYRO30.26664141
127STK100.26037089
128TAOK20.25188846
129PIM20.22782655
130STK390.22730532
131MAP3K80.22255496
132CAMKK10.21717504
133PHKG20.21686811
134PHKG10.21686811
135INSR0.20663699

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.96240194
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.41230066
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.95383264
4Nitrogen metabolism_Homo sapiens_hsa009102.89966594
5Fatty acid degradation_Homo sapiens_hsa000712.83954717
6Arginine biosynthesis_Homo sapiens_hsa002202.66817136
7Complement and coagulation cascades_Homo sapiens_hsa046102.61848077
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.51468475
9Tryptophan metabolism_Homo sapiens_hsa003802.46331223
10Propanoate metabolism_Homo sapiens_hsa006402.39264510
11PPAR signaling pathway_Homo sapiens_hsa033202.31010593
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.22471405
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.21615426
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.09865933
15Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.07552354
16Fatty acid metabolism_Homo sapiens_hsa012122.04953544
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.04591777
18Pyruvate metabolism_Homo sapiens_hsa006202.03372736
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.97026503
20Chemical carcinogenesis_Homo sapiens_hsa052041.96151853
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.94083581
22Selenocompound metabolism_Homo sapiens_hsa004501.90595659
23Peroxisome_Homo sapiens_hsa041461.75757788
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.73744884
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.62161069
26Butanoate metabolism_Homo sapiens_hsa006501.57056516
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.55696126
28Caffeine metabolism_Homo sapiens_hsa002321.55667646
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.55029151
30Carbon metabolism_Homo sapiens_hsa012001.54631468
31Biosynthesis of amino acids_Homo sapiens_hsa012301.47194184
32Bile secretion_Homo sapiens_hsa049761.44189566
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.43322936
34Retinol metabolism_Homo sapiens_hsa008301.41121339
35Phenylalanine metabolism_Homo sapiens_hsa003601.38907921
36Fat digestion and absorption_Homo sapiens_hsa049751.34656756
37Histidine metabolism_Homo sapiens_hsa003401.31188517
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29080591
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.27228886
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26840137
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26066374
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23526189
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23420907
44beta-Alanine metabolism_Homo sapiens_hsa004101.22292522
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.22118498
46Notch signaling pathway_Homo sapiens_hsa043301.21627974
47Sulfur metabolism_Homo sapiens_hsa009201.20393829
48Starch and sucrose metabolism_Homo sapiens_hsa005001.19728132
49Fatty acid biosynthesis_Homo sapiens_hsa000611.18418491
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18100743
51Staphylococcus aureus infection_Homo sapiens_hsa051501.15813201
52Tyrosine metabolism_Homo sapiens_hsa003501.13857969
53Thyroid hormone synthesis_Homo sapiens_hsa049181.13472923
54Vitamin B6 metabolism_Homo sapiens_hsa007501.12218399
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11962905
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08198179
57Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05893302
58Small cell lung cancer_Homo sapiens_hsa052221.04453251
59Melanogenesis_Homo sapiens_hsa049161.03378141
60PI3K-Akt signaling pathway_Homo sapiens_hsa041511.00673185
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96999467
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96521397
63Arginine and proline metabolism_Homo sapiens_hsa003300.95609566
64Gap junction_Homo sapiens_hsa045400.95226197
65Melanoma_Homo sapiens_hsa052180.92734292
66Chronic myeloid leukemia_Homo sapiens_hsa052200.91478925
67Tight junction_Homo sapiens_hsa045300.90267869
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.89463428
69Glutathione metabolism_Homo sapiens_hsa004800.88210674
70Renin secretion_Homo sapiens_hsa049240.85030474
71Cardiac muscle contraction_Homo sapiens_hsa042600.84569864
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84097938
73Lysine degradation_Homo sapiens_hsa003100.83903209
74Sulfur relay system_Homo sapiens_hsa041220.83554906
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83479107
76Glioma_Homo sapiens_hsa052140.82783129
77Axon guidance_Homo sapiens_hsa043600.82688015
78Fatty acid elongation_Homo sapiens_hsa000620.80911814
79ABC transporters_Homo sapiens_hsa020100.80467756
80MicroRNAs in cancer_Homo sapiens_hsa052060.80281511
81Pathways in cancer_Homo sapiens_hsa052000.80058362
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79175842
83cAMP signaling pathway_Homo sapiens_hsa040240.78198622
84ECM-receptor interaction_Homo sapiens_hsa045120.77288863
85Glycerolipid metabolism_Homo sapiens_hsa005610.77043665
86Glucagon signaling pathway_Homo sapiens_hsa049220.76654614
87Insulin signaling pathway_Homo sapiens_hsa049100.75540402
88Gastric acid secretion_Homo sapiens_hsa049710.74189217
89Rap1 signaling pathway_Homo sapiens_hsa040150.73064846
90Circadian rhythm_Homo sapiens_hsa047100.72832243
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71402410
92Other glycan degradation_Homo sapiens_hsa005110.70931093
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.70489715
94Pentose phosphate pathway_Homo sapiens_hsa000300.69197779
95Oxytocin signaling pathway_Homo sapiens_hsa049210.68795930
96Renal cell carcinoma_Homo sapiens_hsa052110.64239934
97Folate biosynthesis_Homo sapiens_hsa007900.64006492
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62507189
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61780101
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.61581344
101Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60594361
102Vitamin digestion and absorption_Homo sapiens_hsa049770.58980634
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.58372417
104Estrogen signaling pathway_Homo sapiens_hsa049150.58335201
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.57285523
106GnRH signaling pathway_Homo sapiens_hsa049120.54354570
107Wnt signaling pathway_Homo sapiens_hsa043100.53146504
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52787791
109Cholinergic synapse_Homo sapiens_hsa047250.52645207
110Endometrial cancer_Homo sapiens_hsa052130.52432456
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52130710
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51904822
113Pertussis_Homo sapiens_hsa051330.51785375
114Focal adhesion_Homo sapiens_hsa045100.51600648
115Pancreatic cancer_Homo sapiens_hsa052120.48579993
116Steroid biosynthesis_Homo sapiens_hsa001000.48442834
117Prostate cancer_Homo sapiens_hsa052150.47557484
118Linoleic acid metabolism_Homo sapiens_hsa005910.46907116
119Insulin resistance_Homo sapiens_hsa049310.46703870
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45635585
121FoxO signaling pathway_Homo sapiens_hsa040680.45605935
122Protein digestion and absorption_Homo sapiens_hsa049740.45296402
123Calcium signaling pathway_Homo sapiens_hsa040200.45196017
124Bladder cancer_Homo sapiens_hsa052190.44782962
125Cocaine addiction_Homo sapiens_hsa050300.43793755
126Fructose and mannose metabolism_Homo sapiens_hsa000510.43729369
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37763878
128One carbon pool by folate_Homo sapiens_hsa006700.36047700
129Dilated cardiomyopathy_Homo sapiens_hsa054140.34870122
130Metabolic pathways_Homo sapiens_hsa011000.34253761
131Prion diseases_Homo sapiens_hsa050200.33706669
132AMPK signaling pathway_Homo sapiens_hsa041520.32367598
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.31222543
134Adherens junction_Homo sapiens_hsa045200.30861898
135Basal cell carcinoma_Homo sapiens_hsa052170.30102979
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.30095825
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29986430
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29940044
139Galactose metabolism_Homo sapiens_hsa000520.29078096
140Amoebiasis_Homo sapiens_hsa051460.29068347
141Proteoglycans in cancer_Homo sapiens_hsa052050.27597869
142TGF-beta signaling pathway_Homo sapiens_hsa043500.22079749
143Hedgehog signaling pathway_Homo sapiens_hsa043400.18579178
144Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.17603218
145Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17196657
146Glycosaminoglycan degradation_Homo sapiens_hsa005310.16432241
147Malaria_Homo sapiens_hsa051440.15361768
148Hippo signaling pathway_Homo sapiens_hsa043900.12069168
149Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.11161408
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.09500935

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