ATMIN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.43476582
2synaptic vesicle maturation (GO:0016188)4.41640738
3pre-miRNA processing (GO:0031054)4.40159265
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.32980811
5regulation of translational termination (GO:0006449)4.25653457
6paraxial mesoderm development (GO:0048339)4.10347541
7locomotory exploration behavior (GO:0035641)3.99744431
8regulation of clathrin-mediated endocytosis (GO:2000369)3.78497841
9synaptic vesicle docking involved in exocytosis (GO:0016081)3.58484471
10layer formation in cerebral cortex (GO:0021819)3.58150062
11cellular protein complex localization (GO:0034629)3.57202885
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.57085890
13regulation of synaptic vesicle exocytosis (GO:2000300)3.52680196
14protein complex localization (GO:0031503)3.50227637
15glutamate secretion (GO:0014047)3.50044002
16negative regulation of histone methylation (GO:0031061)3.44429019
17synaptic vesicle exocytosis (GO:0016079)3.41715267
18sodium ion export (GO:0071436)3.39390954
19histone H2A monoubiquitination (GO:0035518)3.34891769
20desmosome organization (GO:0002934)3.31275541
21histone H4-K12 acetylation (GO:0043983)3.27742631
22neuromuscular process controlling posture (GO:0050884)3.23950601
23hippo signaling (GO:0035329)3.23386610
24regulation of synaptic vesicle transport (GO:1902803)3.19904354
25regulation of Rac protein signal transduction (GO:0035020)3.15404824
26positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.07636306
27regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.06432034
28receptor recycling (GO:0001881)3.06082482
29peptidyl-arginine methylation (GO:0018216)3.02922019
30peptidyl-arginine N-methylation (GO:0035246)3.02922019
31nuclear pore complex assembly (GO:0051292)2.99548355
32neurotransmitter secretion (GO:0007269)2.97327904
33embryonic camera-type eye morphogenesis (GO:0048596)2.94047930
34monoubiquitinated protein deubiquitination (GO:0035520)2.93210298
35embryonic eye morphogenesis (GO:0048048)2.91427990
36regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.89800659
37regulation of centriole replication (GO:0046599)2.89124632
38NLS-bearing protein import into nucleus (GO:0006607)2.88259239
39pore complex assembly (GO:0046931)2.87458392
40nuclear pore organization (GO:0006999)2.86580061
41positive regulation of chromosome segregation (GO:0051984)2.86406160
42regulation of meiosis I (GO:0060631)2.86258891
43cerebellar Purkinje cell differentiation (GO:0021702)2.85204568
44regulation of ARF protein signal transduction (GO:0032012)2.84989560
45peptidyl-arginine omega-N-methylation (GO:0035247)2.84873005
46peptidyl-lysine dimethylation (GO:0018027)2.83678738
47activation of protein kinase A activity (GO:0034199)2.83365942
48proline transport (GO:0015824)2.82532454
49positive regulation of mitotic sister chromatid separation (GO:1901970)2.82241286
50positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.82241286
51positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.82241286
52vocalization behavior (GO:0071625)2.81508327
53regulation of glutamate receptor signaling pathway (GO:1900449)2.78248974
54neuromuscular process controlling balance (GO:0050885)2.78135712
55vesicle transport along microtubule (GO:0047496)2.77649864
56cytoplasmic mRNA processing body assembly (GO:0033962)2.77559891
57piRNA metabolic process (GO:0034587)2.77229099
58cellular potassium ion homeostasis (GO:0030007)2.75811896
59regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.75075110
60neuronal action potential propagation (GO:0019227)2.75006566
61histone H4-K8 acetylation (GO:0043982)2.73362772
62histone H4-K5 acetylation (GO:0043981)2.73362772
63exploration behavior (GO:0035640)2.72790338
64positive regulation of catenin import into nucleus (GO:0035413)2.71790291
65prepulse inhibition (GO:0060134)2.70122202
66synaptonemal complex assembly (GO:0007130)2.69535594
67histone arginine methylation (GO:0034969)2.69224607
68notochord development (GO:0030903)2.69011566
69apical protein localization (GO:0045176)2.68959349
70G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.68050873
71negative regulation of organelle assembly (GO:1902116)2.67498283
72regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.67289403
73dendritic spine morphogenesis (GO:0060997)2.66696158
74embryonic retina morphogenesis in camera-type eye (GO:0060059)2.66077593
75regulation of sister chromatid cohesion (GO:0007063)2.65389290
76peptidyl-threonine phosphorylation (GO:0018107)2.64480537
77planar cell polarity pathway involved in neural tube closure (GO:0090179)2.64478110
78regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.62106502
79synaptic vesicle endocytosis (GO:0048488)2.60368598
80regulation of posttranscriptional gene silencing (GO:0060147)2.60260206
81regulation of gene silencing by miRNA (GO:0060964)2.60260206
82regulation of gene silencing by RNA (GO:0060966)2.60260206
83bundle of His cell to Purkinje myocyte communication (GO:0086069)2.58854045
84regulation of neuronal synaptic plasticity (GO:0048168)2.56989059
85mitotic sister chromatid segregation (GO:0000070)2.56950679
86insulin-like growth factor receptor signaling pathway (GO:0048009)2.55620139
87regulation of long-term neuronal synaptic plasticity (GO:0048169)2.55025549
88histone H4-K16 acetylation (GO:0043984)2.54507479
89histone H2A ubiquitination (GO:0033522)2.53805664
90cell migration in hindbrain (GO:0021535)2.53754859
91regulation of transforming growth factor beta2 production (GO:0032909)2.53702173
92heterochromatin organization (GO:0070828)2.52821365
93gene silencing by RNA (GO:0031047)2.52084119
94regulation of RNA export from nucleus (GO:0046831)2.50780889
95asymmetric protein localization (GO:0008105)2.48643532
96synaptonemal complex organization (GO:0070193)2.47497077
97mitotic G1 DNA damage checkpoint (GO:0031571)2.47016584
98cytoskeletal anchoring at plasma membrane (GO:0007016)2.46888231
99regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.46520269
100protein localization to microtubule (GO:0035372)2.46381245
101peptidyl-threonine modification (GO:0018210)2.44933771
102membrane disassembly (GO:0030397)2.43999473
103nuclear envelope disassembly (GO:0051081)2.43999473
104regulation of early endosome to late endosome transport (GO:2000641)2.43850125
105negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.43184254
106negative regulation of histone modification (GO:0031057)2.42688871
107intracellular estrogen receptor signaling pathway (GO:0030520)2.42512880
108genitalia morphogenesis (GO:0035112)2.41757005
109mitotic sister chromatid cohesion (GO:0007064)2.40878455
110ionotropic glutamate receptor signaling pathway (GO:0035235)2.40741619
111branching involved in salivary gland morphogenesis (GO:0060445)2.40419469
112mitotic cytokinesis (GO:0000281)2.39970861
113regulation of nucleobase-containing compound transport (GO:0032239)2.38525965
114positive regulation of SMAD protein import into nucleus (GO:0060391)2.38359239
115mitotic chromosome condensation (GO:0007076)2.37993400
116protein localization to kinetochore (GO:0034501)2.37554381
117negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.37421994
118negative regulation of cell killing (GO:0031342)2.37421994
119long-term memory (GO:0007616)2.36937070
120RNA stabilization (GO:0043489)2.36785201
121mRNA stabilization (GO:0048255)2.36785201
122DNA unwinding involved in DNA replication (GO:0006268)2.36354620
123peripheral nervous system axon ensheathment (GO:0032292)2.35523639
124myelination in peripheral nervous system (GO:0022011)2.35523639
125mitotic nuclear envelope disassembly (GO:0007077)2.35101012
126organelle transport along microtubule (GO:0072384)2.35036059
127mitotic metaphase plate congression (GO:0007080)2.34940957
128intestinal epithelial cell development (GO:0060576)2.34489661
129protein localization to chromosome, centromeric region (GO:0071459)2.33669338
130regulation of synapse structural plasticity (GO:0051823)2.33478851
131RNA localization (GO:0006403)2.33294358
132negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.33190271
133negative regulation of keratinocyte proliferation (GO:0010839)2.32717371
134N-terminal protein amino acid acetylation (GO:0006474)2.32229700
135corticosteroid receptor signaling pathway (GO:0031958)2.31371101
136positive regulation of dendritic spine morphogenesis (GO:0061003)2.31011900
137sister chromatid segregation (GO:0000819)2.29766635
138negative regulation of chromatin modification (GO:1903309)2.29757879
139regulation of catenin import into nucleus (GO:0035412)2.29664430
140regulation of NFAT protein import into nucleus (GO:0051532)2.29565959
141body morphogenesis (GO:0010171)2.28974493
142eye morphogenesis (GO:0048592)2.27976950
143chondrocyte development (GO:0002063)2.25825344
144positive regulation of insulin receptor signaling pathway (GO:0046628)2.24949223
145convergent extension (GO:0060026)2.23433223
146ectoderm development (GO:0007398)2.23148713
147SMAD protein complex assembly (GO:0007183)2.22985129
148positive regulation of cytokinesis (GO:0032467)2.21353949
149embryonic foregut morphogenesis (GO:0048617)2.20085101
150adherens junction assembly (GO:0034333)2.19218388
151cytoskeleton-dependent cytokinesis (GO:0061640)2.16877138
152gastrulation with mouth forming second (GO:0001702)2.15582370
153keratinocyte proliferation (GO:0043616)2.15023135
154positive regulation of macroautophagy (GO:0016239)2.14174859
155negative regulation of dendrite morphogenesis (GO:0050774)2.13750173
156dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.13375120
157nodal signaling pathway (GO:0038092)2.12590632
158innervation (GO:0060384)2.12552239
159regulation of establishment of planar polarity (GO:0090175)2.12500107
160positive regulation of glucose transport (GO:0010828)2.11929104
161Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.11646675
162negative regulation of DNA repair (GO:0045738)2.11496752
163establishment of nucleus localization (GO:0040023)2.11464188
164embryonic process involved in female pregnancy (GO:0060136)2.11053410
165positive regulation of glucose import (GO:0046326)2.10463054
166branching involved in mammary gland duct morphogenesis (GO:0060444)2.10072240
167hemidesmosome assembly (GO:0031581)2.08146954
168negative regulation of embryonic development (GO:0045992)2.07451727
169protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.04570610
170cell-substrate adherens junction assembly (GO:0007045)2.04445314
171focal adhesion assembly (GO:0048041)2.04445314
172dorsal/ventral axis specification (GO:0009950)2.03564503
173positive regulation of cellular response to insulin stimulus (GO:1900078)2.02616585
174regulation of centrosome duplication (GO:0010824)2.02452423
175establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.02273049
176regulation of keratinocyte proliferation (GO:0010837)2.02262959
177camera-type eye morphogenesis (GO:0048593)2.02076690
178myoblast fusion (GO:0007520)2.00650065
179protein export from nucleus (GO:0006611)1.99775616
180cell migration involved in gastrulation (GO:0042074)1.99497787

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.06945494
2E2F7_22180533_ChIP-Seq_HELA_Human3.58275918
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.37283957
4EZH2_22144423_ChIP-Seq_EOC_Human3.02307721
5AR_21909140_ChIP-Seq_LNCAP_Human2.86020134
6SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.81424366
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.74801370
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.72632030
9SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.64499012
10ZNF263_19887448_ChIP-Seq_K562_Human2.63337963
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.61933609
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.56655009
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.34539436
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.33384013
15TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.30108680
16ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.29376749
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.25714125
18ESR1_20079471_ChIP-ChIP_T-47D_Human2.24290750
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23954579
20MYC_22102868_ChIP-Seq_BL_Human2.22778727
21ZFP281_18757296_ChIP-ChIP_E14_Mouse2.19931476
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.19620403
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.16389061
24NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.16310395
25STAT6_21828071_ChIP-Seq_BEAS2B_Human2.06002401
26ESR2_21235772_ChIP-Seq_MCF-7_Human2.05278672
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03599998
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.02425170
29ZFP281_27345836_Chip-Seq_ESCs_Mouse2.00121675
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.98607508
31KDM2B_26808549_Chip-Seq_DND41_Human1.96099053
32CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.89822424
33REST_21632747_ChIP-Seq_MESCs_Mouse1.89215985
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.88442361
35NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.87798029
36* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.85980237
37RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.82519012
38RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.80328576
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.79585957
40KDM2B_26808549_Chip-Seq_K562_Human1.79302636
41AHR_22903824_ChIP-Seq_MCF-7_Human1.75619587
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.75284173
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.75284173
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.75284173
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.71883172
46CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.70483364
47CTNNB1_20460455_ChIP-Seq_HCT116_Human1.70244267
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.69204904
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67089137
50TCF7_22412390_ChIP-Seq_EML_Mouse1.65786110
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.65339948
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.60144681
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56788269
54PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.54360921
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51071993
56PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.51034535
57SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.50891818
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49230632
59* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48562637
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47487682
61EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.46568883
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.45606598
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.45604959
64FOXM1_26456572_ChIP-Seq_MCF-7_Human1.44227452
65DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.43508523
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.43342991
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39704944
68TCF3_18692474_ChIP-Seq_MESCs_Mouse1.38871659
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38820467
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.38808514
71YAP1_20516196_ChIP-Seq_MESCs_Mouse1.38709927
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37399636
73ISL1_27105846_Chip-Seq_CPCs_Mouse1.35406275
74EP300_21415370_ChIP-Seq_HL-1_Mouse1.34397139
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33615656
76SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.33538612
77POU5F1_16518401_ChIP-PET_MESCs_Mouse1.33404882
78NANOG_21062744_ChIP-ChIP_HESCs_Human1.33232913
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32553421
80TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30546578
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30001346
82SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.29970716
83CHD1_26751641_Chip-Seq_LNCaP_Human1.28533684
84CLOCK_20551151_ChIP-Seq_293T_Human1.28522373
85MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24357018
86FOXO3_23340844_ChIP-Seq_DLD1_Human1.23546429
87HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23372441
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22773611
89STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22729859
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.21704171
91TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.20659410
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20377509
93E2F4_17652178_ChIP-ChIP_JURKAT_Human1.19851636
94PKCTHETA_26484144_Chip-Seq_BREAST_Human1.19676135
95RING1B_27294783_Chip-Seq_NPCs_Mouse1.19573441
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19463872
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19355703
98TCF3_18692474_ChIP-Seq_MEFs_Mouse1.18310384
99SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18058157
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18002833
101TRIM28_21343339_ChIP-Seq_HEK293_Human1.15678950
102IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15523378
103NANOG_18692474_ChIP-Seq_MESCs_Mouse1.15320638
104RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11993137
105NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11639782
106CREB1_26743006_Chip-Seq_LNCaP_Human1.11366331
107EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.10753452
108POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.10286461
109TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09453771
110MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08592907
111DROSHA_22980978_ChIP-Seq_HELA_Human1.08225559
112WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07523705
113SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07021091
114KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06592268
115NANOG_16518401_ChIP-PET_MESCs_Mouse1.06587808
116PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06559433
117TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.06221241
118TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.06177058
119EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05603203
120KAP1_27257070_Chip-Seq_ESCs_Mouse1.04374621
121TCF4_18268006_ChIP-ChIP_LS174T_Human1.03977961
122SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02947077
123SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02947077
124E2F1_21310950_ChIP-Seq_MCF-7_Human1.02400252
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01500278
126HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01121922
127STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01032596
128TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00235725
129DPY_21335234_ChIP-Seq_ESCs_Mouse0.98532343
130SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98152321
131P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97028826
132KDM5A_27292631_Chip-Seq_BREAST_Human0.96767653
133ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96016615
134PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93857536
135SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93778880
136PIAS1_25552417_ChIP-Seq_VCAP_Human0.93624314
137GATA3_24758297_ChIP-Seq_MCF-7_Human0.93193205
138SMC4_20622854_ChIP-Seq_HELA_Human0.92975764
139POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.92759585
140RUNX1_27514584_Chip-Seq_MCF-7_Human0.92708905
141FOXA2_19822575_ChIP-Seq_HepG2_Human0.92488232
142KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92456082
143OCT4_19829295_ChIP-Seq_ESCs_Human0.92396246
144SOX2_18692474_ChIP-Seq_MESCs_Mouse0.91817684
145FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91680499
146ATF3_27146783_Chip-Seq_COLON_Human0.90652213
147TET1_21490601_ChIP-Seq_MESCs_Mouse0.89035990
148ERG_21242973_ChIP-ChIP_JURKAT_Human0.88174924
149TBX3_20139965_ChIP-Seq_ESCs_Mouse0.86820000
150ELK4_26923725_Chip-Seq_MESODERM_Mouse0.86164604
151MYC_18555785_ChIP-Seq_MESCs_Mouse0.85660777
152FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.85561086
153TBX3_20139965_ChIP-Seq_MESCs_Mouse0.85420760
154GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.85179088
155P68_20966046_ChIP-Seq_HELA_Human0.84321718

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.09598223
2MP0003941_abnormal_skin_development2.92654156
3MP0003635_abnormal_synaptic_transmissio2.92148137
4MP0004270_analgesia2.91872451
5MP0002653_abnormal_ependyma_morphology2.68135084
6MP0010234_abnormal_vibrissa_follicle2.65931784
7MP0008877_abnormal_DNA_methylation2.53052220
8MP0003880_abnormal_central_pattern2.52803428
9MP0003787_abnormal_imprinting2.52693961
10MP0002796_impaired_skin_barrier2.36989798
11MP0003123_paternal_imprinting2.34709580
12MP0000579_abnormal_nail_morphology2.23247488
13MP0009046_muscle_twitch2.23087164
14MP0002063_abnormal_learning/memory/cond2.21743831
15MP0005409_darkened_coat_color2.16233199
16MP0009780_abnormal_chondrocyte_physiolo2.08727432
17MP0002064_seizures2.03885334
18MP0003646_muscle_fatigue2.03765009
19MP0009745_abnormal_behavioral_response1.97294233
20MP0005257_abnormal_intraocular_pressure1.96793282
21MP0004957_abnormal_blastocyst_morpholog1.88295141
22MP0008057_abnormal_DNA_replication1.88030220
23MP0010352_gastrointestinal_tract_polyps1.85193112
24MP0003111_abnormal_nucleus_morphology1.81750096
25MP0000537_abnormal_urethra_morphology1.77535785
26MP0004858_abnormal_nervous_system1.76716883
27MP0002009_preneoplasia1.75716988
28MP0005076_abnormal_cell_differentiation1.71562202
29MP0002734_abnormal_mechanical_nocicepti1.70554517
30MP0010678_abnormal_skin_adnexa1.70378469
31MP0002572_abnormal_emotion/affect_behav1.70105780
32MP0005248_abnormal_Harderian_gland1.69859693
33MP0001730_embryonic_growth_arrest1.68513613
34MP0003693_abnormal_embryo_hatching1.68271037
35MP0001968_abnormal_touch/_nociception1.66927853
36MP0000566_synostosis1.64726063
37MP0005423_abnormal_somatic_nervous1.60154194
38MP0003077_abnormal_cell_cycle1.59648530
39MP0010307_abnormal_tumor_latency1.56613391
40MP0000762_abnormal_tongue_morphology1.55303314
41MP0002822_catalepsy1.52305855
42MP0010094_abnormal_chromosome_stability1.52211233
43MP0001299_abnormal_eye_distance/1.51051023
44MP0002272_abnormal_nervous_system1.50784946
45MP0010030_abnormal_orbit_morphology1.49864986
46MP0004811_abnormal_neuron_physiology1.47777825
47MP0008961_abnormal_basal_metabolism1.45845393
48MP0003121_genomic_imprinting1.45762115
49MP0005501_abnormal_skin_physiology1.45128422
50MP0000462_abnormal_digestive_system1.44070623
51MP0000428_abnormal_craniofacial_morphol1.43145982
52MP0003942_abnormal_urinary_system1.42581453
53MP0003937_abnormal_limbs/digits/tail_de1.42043312
54MP0002697_abnormal_eye_size1.40965723
55MP0002733_abnormal_thermal_nociception1.40922255
56MP0000350_abnormal_cell_proliferation1.40433777
57MP0002084_abnormal_developmental_patter1.40170864
58MP0004185_abnormal_adipocyte_glucose1.39473303
59MP0004264_abnormal_extraembryonic_tissu1.38988389
60MP0004885_abnormal_endolymph1.37057019
61MP0009672_abnormal_birth_weight1.36745691
62MP0003935_abnormal_craniofacial_develop1.36375851
63MP0009053_abnormal_anal_canal1.33389532
64MP0000534_abnormal_ureter_morphology1.33125429
65MP0001486_abnormal_startle_reflex1.31025135
66MP0001970_abnormal_pain_threshold1.30177716
67MP0001501_abnormal_sleep_pattern1.28949386
68MP0004510_myositis1.28156875
69MP0003303_peritoneal_inflammation1.22812232
70MP0005310_abnormal_salivary_gland1.22331603
71MP0000733_abnormal_muscle_development1.21799608
72MP0003755_abnormal_palate_morphology1.21776330
73MP0002233_abnormal_nose_morphology1.20769651
74MP0000955_abnormal_spinal_cord1.20722862
75MP0003115_abnormal_respiratory_system1.20714529
76MP0001697_abnormal_embryo_size1.19567700
77MP0004233_abnormal_muscle_weight1.19044693
78MP0005380_embryogenesis_phenotype1.18871520
79MP0001672_abnormal_embryogenesis/_devel1.18871520
80MP0002909_abnormal_adrenal_gland1.18543052
81MP0008569_lethality_at_weaning1.18252080
82MP0004924_abnormal_behavior1.17904021
83MP0005386_behavior/neurological_phenoty1.17904021
84MP0009379_abnormal_foot_pigmentation1.16587311
85MP0003385_abnormal_body_wall1.16347388
86MP0000383_abnormal_hair_follicle1.16324315
87MP0001849_ear_inflammation1.15984546
88MP0002877_abnormal_melanocyte_morpholog1.14253808
89MP0005275_abnormal_skin_tensile1.13895056
90MP0002184_abnormal_innervation1.12829165
91MP0001188_hyperpigmentation1.12042775
92MP0002152_abnormal_brain_morphology1.11744636
93MP0002085_abnormal_embryonic_tissue1.11578090
94MP0003329_amyloid_beta_deposits1.11335344
95MP0005623_abnormal_meninges_morphology1.10494371
96MP0005410_abnormal_fertilization1.10236586
97MP0000432_abnormal_head_morphology1.09716987
98MP0002092_abnormal_eye_morphology1.09578013
99MP0001929_abnormal_gametogenesis1.08958230
100MP0001440_abnormal_grooming_behavior1.08358349
101MP0004197_abnormal_fetal_growth/weight/1.07501640
102MP0002086_abnormal_extraembryonic_tissu1.06509395
103MP0003861_abnormal_nervous_system1.05458338
104MP0001348_abnormal_lacrimal_gland1.05384498
105MP0003984_embryonic_growth_retardation1.05304739
106MP0003122_maternal_imprinting1.04302264
107MP0009703_decreased_birth_body1.03446657
108MP0003453_abnormal_keratinocyte_physiol1.02774430
109MP0003698_abnormal_male_reproductive1.02397751
110MP0002088_abnormal_embryonic_growth/wei1.02390219
111MP0000377_abnormal_hair_follicle1.02307174
112MP0002098_abnormal_vibrissa_morphology1.01083128
113MP0000778_abnormal_nervous_system1.01064050
114MP0005666_abnormal_adipose_tissue1.00973538
115MP0002066_abnormal_motor_capabilities/c1.00252738
116MP0001177_atelectasis0.99944474
117MP0002067_abnormal_sensory_capabilities0.99664790
118MP0001286_abnormal_eye_development0.96151882
119MP0003566_abnormal_cell_adhesion0.96029946
120MP0002080_prenatal_lethality0.95929361
121MP0002060_abnormal_skin_morphology0.95561455
122MP0002882_abnormal_neuron_morphology0.95376658
123MP0000627_abnormal_mammary_gland0.94714551
124MP0009384_cardiac_valve_regurgitation0.94555874
125MP0000569_abnormal_digit_pigmentation0.94229861
126MP0001340_abnormal_eyelid_morphology0.93582190
127MP0005377_hearing/vestibular/ear_phenot0.93028928
128MP0003878_abnormal_ear_physiology0.93028928
129MP0002896_abnormal_bone_mineralization0.92525242
130MP0002163_abnormal_gland_morphology0.91938709
131MP0002089_abnormal_postnatal_growth/wei0.89842209
132MP0003890_abnormal_embryonic-extraembry0.89818066
133MP0001293_anophthalmia0.88916196
134MP0003705_abnormal_hypodermis_morpholog0.88485168
135MP0002736_abnormal_nociception_after0.88163145
136MP0002116_abnormal_craniofacial_bone0.88104736
137MP0000467_abnormal_esophagus_morphology0.87376613
138MP0001145_abnormal_male_reproductive0.85226462
139MP0002735_abnormal_chemical_nociception0.85144601
140MP0002081_perinatal_lethality0.85064795
141MP0002210_abnormal_sex_determination0.84967073
142MP0008770_decreased_survivor_rate0.84858608
143MP0003632_abnormal_nervous_system0.84692124
144MP0008872_abnormal_physiological_respon0.84033182
145MP0003879_abnormal_hair_cell0.80900814
146MP0004145_abnormal_muscle_electrophysio0.80622556
147MP0003119_abnormal_digestive_system0.79959558
148MP0002161_abnormal_fertility/fecundity0.79914968
149MP0002111_abnormal_tail_morphology0.79815123
150MP0004272_abnormal_basement_membrane0.77292940
151MP0003631_nervous_system_phenotype0.77199518
152MP0002269_muscular_atrophy0.76364948
153MP0003091_abnormal_cell_migration0.76133218
154MP0000653_abnormal_sex_gland0.76057931
155MP0009250_abnormal_appendicular_skeleto0.75538242
156MP0002557_abnormal_social/conspecific_i0.75416782
157MP0005621_abnormal_cell_physiology0.73052655
158MP0000747_muscle_weakness0.72484616
159MP0003633_abnormal_nervous_system0.72215314
160MP0003283_abnormal_digestive_organ0.69132054
161MP0005499_abnormal_olfactory_system0.66776554
162MP0005394_taste/olfaction_phenotype0.66776554

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.28608594
2Visual hallucinations (HP:0002367)3.89136918
3Abnormality of the lower motor neuron (HP:0002366)3.76602289
4Focal motor seizures (HP:0011153)3.71385783
5Ependymoma (HP:0002888)3.48314598
6Asymmetry of the thorax (HP:0001555)3.41432260
7Focal seizures (HP:0007359)3.34802550
8Abnormality of the labia minora (HP:0012880)3.17622953
9Dysmetric saccades (HP:0000641)3.04332580
10Astrocytoma (HP:0009592)3.01611351
11Abnormality of the astrocytes (HP:0100707)3.01611351
12Right ventricular cardiomyopathy (HP:0011663)3.01342248
13Atonic seizures (HP:0010819)2.97857042
14Urinary bladder sphincter dysfunction (HP:0002839)2.94466812
15Impaired smooth pursuit (HP:0007772)2.84546869
16Urinary urgency (HP:0000012)2.72807185
17Supranuclear gaze palsy (HP:0000605)2.70280164
18Genetic anticipation (HP:0003743)2.66252200
19Impaired vibration sensation in the lower limbs (HP:0002166)2.61714786
20Microglossia (HP:0000171)2.61494888
21Neoplasm of the oral cavity (HP:0100649)2.59898600
22Progressive cerebellar ataxia (HP:0002073)2.55101413
23Postural instability (HP:0002172)2.53800645
24Abnormality of ocular smooth pursuit (HP:0000617)2.52154821
25Absence seizures (HP:0002121)2.51158419
26Aplasia involving bones of the upper limbs (HP:0009823)2.47409856
27Aplasia of the phalanges of the hand (HP:0009802)2.47409856
28Aplasia involving bones of the extremities (HP:0009825)2.47409856
29Amyotrophic lateral sclerosis (HP:0007354)2.44369873
30Action tremor (HP:0002345)2.44242212
31Annular pancreas (HP:0001734)2.35756235
32Ventricular fibrillation (HP:0001663)2.34947029
33Papillary thyroid carcinoma (HP:0002895)2.34114396
34Lip pit (HP:0100267)2.32582485
35Pointed chin (HP:0000307)2.32454033
36Termporal pattern (HP:0011008)2.29714107
37Insidious onset (HP:0003587)2.29714107
38Apathy (HP:0000741)2.29597417
39Dialeptic seizures (HP:0011146)2.28491854
40Ankle clonus (HP:0011448)2.25879113
41Resting tremor (HP:0002322)2.24089619
42Male infertility (HP:0003251)2.23976106
43Dysdiadochokinesis (HP:0002075)2.20615971
44Sparse lateral eyebrow (HP:0005338)2.19558202
45Mutism (HP:0002300)2.18915426
46Curly hair (HP:0002212)2.14827936
47Heterotopia (HP:0002282)2.14269042
48Truncal ataxia (HP:0002078)2.13593360
49Febrile seizures (HP:0002373)2.11891594
50Generalized tonic-clonic seizures (HP:0002069)2.11508217
51Papilledema (HP:0001085)2.08232940
52Deep palmar crease (HP:0006191)2.07152105
53Anal stenosis (HP:0002025)2.06917668
54Bundle branch block (HP:0011710)2.06552011
55Shawl scrotum (HP:0000049)2.05699915
56Angiofibromas (HP:0010615)2.05142568
57Adenoma sebaceum (HP:0009720)2.05142568
58Arterial tortuosity (HP:0005116)2.04379439
59Hemiplegia (HP:0002301)2.01786127
60Diminished motivation (HP:0000745)2.01016276
61Neoplasm of striated muscle (HP:0009728)2.00500472
62Overriding aorta (HP:0002623)2.00468942
63Facial cleft (HP:0002006)2.00397209
64Gaze-evoked nystagmus (HP:0000640)2.00370866
65Glioma (HP:0009733)2.00149611
66Renovascular hypertension (HP:0100817)1.99679239
67Basal cell carcinoma (HP:0002671)1.99404253
68Abnormality of the lacrimal duct (HP:0011481)1.98796968
69Amblyopia (HP:0000646)1.98380862
70Deep philtrum (HP:0002002)1.97341549
71Depression (HP:0000716)1.97183156
72Absent eyelashes (HP:0000561)1.97132509
73Abnormal social behavior (HP:0012433)1.97020985
74Impaired social interactions (HP:0000735)1.97020985
75Uterine leiomyosarcoma (HP:0002891)1.96918530
76Leiomyosarcoma (HP:0100243)1.96918530
77Hyperacusis (HP:0010780)1.95378420
78Increased nuchal translucency (HP:0010880)1.95165075
79Medulloblastoma (HP:0002885)1.93953161
80Hand muscle atrophy (HP:0009130)1.93216500
81Macroorchidism (HP:0000053)1.93012400
82Dysmetria (HP:0001310)1.92788155
83Vertebral arch anomaly (HP:0008438)1.92708127
84Abnormality of permanent molar morphology (HP:0011071)1.92172716
85Abnormality of the dental root (HP:0006486)1.92172716
86Taurodontia (HP:0000679)1.92172716
87Insomnia (HP:0100785)1.91989981
88Choanal stenosis (HP:0000452)1.91391755
89Overgrowth (HP:0001548)1.90988746
90Abnormality of the nasolacrimal system (HP:0000614)1.90599133
91Poor eye contact (HP:0000817)1.90226731
92Prominent nose (HP:0000448)1.89233096
93Inappropriate behavior (HP:0000719)1.88931862
94Enlarged penis (HP:0000040)1.88824351
95Pterygium (HP:0001059)1.88573376
96Abnormality of binocular vision (HP:0011514)1.87901694
97Diplopia (HP:0000651)1.87901694
98Sandal gap (HP:0001852)1.87695834
99Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.87305579
100Cubitus valgus (HP:0002967)1.86998281
101Abnormality of the distal phalanx of the thumb (HP:0009617)1.86645167
102Rhabdomyosarcoma (HP:0002859)1.86451863
103Transitional cell carcinoma of the bladder (HP:0006740)1.86120568
104Germ cell neoplasia (HP:0100728)1.85006599
105Rapidly progressive (HP:0003678)1.84947582
106EMG: neuropathic changes (HP:0003445)1.84893761
107Biliary tract neoplasm (HP:0100574)1.84601082
108Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.84473213
109Achilles tendon contracture (HP:0001771)1.83017153
110Epileptic encephalopathy (HP:0200134)1.82464509
111Abnormality of molar (HP:0011077)1.81715216
112Abnormality of molar morphology (HP:0011070)1.81715216
113Spastic gait (HP:0002064)1.81659843
114Hepatoblastoma (HP:0002884)1.80966572
115Upper limb amyotrophy (HP:0009129)1.80930286
116Distal upper limb amyotrophy (HP:0007149)1.80930286
117Menstrual irregularities (HP:0000858)1.79388756
118Facial hemangioma (HP:0000329)1.79250252
119Gastrointestinal carcinoma (HP:0002672)1.78986879
120Malignant gastrointestinal tract tumors (HP:0006749)1.78986879
121Fibroma (HP:0010614)1.78928298
122Midline defect of the nose (HP:0004122)1.78171876
123Popliteal pterygium (HP:0009756)1.77834246
124Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.77274989
125Ankyloglossia (HP:0010296)1.77252464
126Difficulty running (HP:0009046)1.76431846
127Syringomyelia (HP:0003396)1.76130281
128Spinal cord lesions (HP:0100561)1.76130281
129Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.75466623
130Neoplasm of the heart (HP:0100544)1.75014607
131Septate vagina (HP:0001153)1.74957853
132Vascular tortuosity (HP:0004948)1.74932873
133Absent eyebrow (HP:0002223)1.74815196
134Arnold-Chiari malformation (HP:0002308)1.73537905
135Thyroid carcinoma (HP:0002890)1.72671265
136Lower limb asymmetry (HP:0100559)1.72665883
137Spinal muscular atrophy (HP:0007269)1.72510566
138Intention tremor (HP:0002080)1.72022204
139Bladder carcinoma (HP:0002862)1.71672236
140Bladder neoplasm (HP:0009725)1.71672236
141Progressive external ophthalmoplegia (HP:0000590)1.71550339
142Impaired vibratory sensation (HP:0002495)1.70940816
143Intellectual disability, profound (HP:0002187)1.70850155
144Horizontal nystagmus (HP:0000666)1.70831476
145Abnormality of the corticospinal tract (HP:0002492)1.70599784
146Long palpebral fissure (HP:0000637)1.70403720
147Carpal bone hypoplasia (HP:0001498)1.69550222
148Cerebral hypomyelination (HP:0006808)1.69450232
149Fibrous tissue neoplasm (HP:0012316)1.69434658
150Bradykinesia (HP:0002067)1.69351057
151Agnosia (HP:0010524)1.69045054
152Hemiparesis (HP:0001269)1.68727681
153Cerebral inclusion bodies (HP:0100314)1.68295884
154Renal cell carcinoma (HP:0005584)1.67046377
155Sensory axonal neuropathy (HP:0003390)1.64918223
156Partial duplication of thumb phalanx (HP:0009944)1.64718932
157Elfin facies (HP:0004428)1.64574950
158Renal duplication (HP:0000075)1.62750744
159Abnormality of the dental pulp (HP:0006479)1.62219920
160Coronal craniosynostosis (HP:0004440)1.59754507
161Dental malocclusion (HP:0000689)1.58815365
162Shallow orbits (HP:0000586)1.57823268
163Duplication of thumb phalanx (HP:0009942)1.57645882
164Abnormality of the phalanges of the hallux (HP:0010057)1.56924160
165Cystic hygroma (HP:0000476)1.56599612
166Abnormality of incisor morphology (HP:0011063)1.54235749
167Abnormality of the salivary glands (HP:0010286)1.53551004
168Absent frontal sinuses (HP:0002688)1.51168185
169Nephroblastoma (Wilms tumor) (HP:0002667)1.50521555
170Capillary hemangiomas (HP:0005306)1.49767337
171Advanced eruption of teeth (HP:0006288)1.48081807
172Nasolacrimal duct obstruction (HP:0000579)1.47933464
173Abnormality of nail color (HP:0100643)1.46287880
174Hyperparathyroidism (HP:0000843)1.45823573
175Embryonal renal neoplasm (HP:0011794)1.43943716
176Omphalocele (HP:0001539)1.43733485
177Flat acetabular roof (HP:0003180)1.43518675
178Hypoplasia of dental enamel (HP:0006297)1.43436196
179Missing ribs (HP:0000921)1.43318714
180Partial duplication of the phalanx of hand (HP:0009999)1.43105960
181Myelomeningocele (HP:0002475)1.43068602
182Obstructive sleep apnea (HP:0002870)1.43064674
183Buphthalmos (HP:0000557)1.42824811
184Protrusio acetabuli (HP:0003179)1.41734849
185Obsessive-compulsive behavior (HP:0000722)1.41606499
186Abnormality of the gastric mucosa (HP:0004295)1.41063899
187Precocious puberty (HP:0000826)1.40578411

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.76900988
2KSR23.25190872
3PRKD33.12307057
4LATS22.87609895
5NTRK32.65227745
6MAP3K42.51918136
7PNCK2.51719182
8CDK122.51557583
9STK392.49334408
10TYRO32.40918612
11MAP3K102.40692909
12PAK62.38957139
13TAOK12.26503967
14EEF2K2.18072077
15NEK12.02659718
16STK381.98113202
17CDC71.95955631
18PDGFRA1.95791073
19ALK1.88565287
20BRD41.85530656
21EPHA41.79863806
22CAMK1D1.75357272
23STK241.75253139
24CASK1.65562515
25SCYL21.61889534
26MINK11.56716771
27NTRK11.56511674
28MAP3K131.56091730
29NTRK21.48778086
30NEK61.47559534
31MAP2K41.45817052
32ICK1.44248837
33NEK21.43181737
34KSR11.39545058
35PKN21.34467567
36RAF11.32618896
37ARAF1.28315593
38FGFR11.27272756
39TRIB31.27230007
40EIF2AK31.26026960
41AKT31.25638281
42LATS11.23603231
43MST1R1.23081103
44RET1.22563759
45STK111.21310339
46MET1.19690667
47CAMKK11.19061523
48SIK11.16339992
49PTK21.12555042
50WNK41.10838757
51PBK1.09715145
52PIK3CA1.08351705
53STK31.08160786
54MAP3K61.07799247
55EPHA21.06665239
56PDK31.05247870
57PDK41.05247870
58MAP3K21.04109512
59DYRK31.02576063
60RIPK11.02422145
61STK38L0.99836371
62DAPK20.99236865
63DAPK10.98426959
64RPS6KB10.96804650
65SGK20.94572193
66TTK0.90387306
67MARK10.89482890
68RIPK40.87012368
69FGFR20.87002731
70PDGFRB0.86985181
71SIK20.86745352
72PLK40.85111386
73TNIK0.82451466
74TTN0.82056445
75GRK50.81710378
76CDK50.80117760
77PRPF4B0.77551196
78DMPK0.77174511
79MAPK100.73440986
80CHEK20.73186991
81MAP2K70.72503943
82SGK4940.71839248
83SGK2230.71839248
84PDK10.70012779
85CHEK10.68622956
86YES10.68228229
87MAPKAPK30.66992971
88BMX0.65925372
89CAMK1G0.65374144
90MELK0.64140488
91AKT20.63660376
92PAK20.63553172
93CDK60.62960012
94CDK70.62391507
95MTOR0.60447407
96FES0.60396397
97CSNK1E0.60325867
98TSSK60.58124513
99CDK20.57818289
100PLK10.56358084
101WEE10.56272311
102BRSK20.56000926
103CDK150.55221258
104MAP3K10.54758167
105CDK80.54731461
106WNK10.53790102
107CDK140.53567834
108BRSK10.53072511
109ERBB40.53020758
110PLK30.52578628
111CSNK1D0.52448512
112CDK190.51147411
113MAP3K80.50845386
114SMG10.50328148
115EIF2AK10.50145311
116MAP3K120.49799137
117CAMK2B0.49091448
118CDK180.48967863
119PDK20.48472777
120CDK11A0.48315222
121CSNK1G20.47707615
122RPS6KB20.47561673
123MARK20.47506422
124FGFR30.47290377
125ROCK20.46556491
126PDPK10.46350864
127MAP3K50.45601591
128RPS6KA20.44876812
129PAK40.43995278
130ERBB30.43856083
131PHKG20.43161254
132PHKG10.43161254
133RPS6KA30.43158716
134EIF2AK20.43072487
135MUSK0.42443684
136MAPK130.41926481
137ILK0.41889347
138GSK3B0.38572480
139CDK40.38409565
140BRAF0.38017288
141LIMK10.37900811
142TESK10.37885620
143MAP3K110.37856724
144MKNK20.37679822
145ATM0.37609904
146UHMK10.37471764
147FGFR40.36111181
148NEK90.35627595
149SGK30.33758605
150PRKAA10.33021626
151RPS6KA10.32963219
152PRKCH0.32199913
153PAK30.31420732
154CDK10.31104377
155LMTK20.30350644
156MAPK140.29776917

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.29927933
2Long-term potentiation_Homo sapiens_hsa047202.18460181
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.95859696
4Olfactory transduction_Homo sapiens_hsa047401.94393637
5Nicotine addiction_Homo sapiens_hsa050331.83355558
6mTOR signaling pathway_Homo sapiens_hsa041501.78395486
7Oocyte meiosis_Homo sapiens_hsa041141.77565040
8Dorso-ventral axis formation_Homo sapiens_hsa043201.63904278
9Amphetamine addiction_Homo sapiens_hsa050311.63045352
10Wnt signaling pathway_Homo sapiens_hsa043101.50303730
11Glutamatergic synapse_Homo sapiens_hsa047241.49566341
12GABAergic synapse_Homo sapiens_hsa047271.49361278
13Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.49341930
14Dopaminergic synapse_Homo sapiens_hsa047281.49108632
15TGF-beta signaling pathway_Homo sapiens_hsa043501.48942856
16Glioma_Homo sapiens_hsa052141.45085592
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40441083
18GnRH signaling pathway_Homo sapiens_hsa049121.39930310
19Circadian entrainment_Homo sapiens_hsa047131.38908522
20Estrogen signaling pathway_Homo sapiens_hsa049151.37879211
21Gastric acid secretion_Homo sapiens_hsa049711.37035846
22Prostate cancer_Homo sapiens_hsa052151.36152023
23Proteoglycans in cancer_Homo sapiens_hsa052051.29448538
24Oxytocin signaling pathway_Homo sapiens_hsa049211.29394348
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.29276486
26Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27123397
27Salivary secretion_Homo sapiens_hsa049701.25787337
28Cholinergic synapse_Homo sapiens_hsa047251.25719098
29Morphine addiction_Homo sapiens_hsa050321.25482523
30RNA transport_Homo sapiens_hsa030131.20691725
31Long-term depression_Homo sapiens_hsa047301.19568945
32VEGF signaling pathway_Homo sapiens_hsa043701.19048265
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18629396
34ErbB signaling pathway_Homo sapiens_hsa040121.17927180
35Insulin secretion_Homo sapiens_hsa049111.17182332
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17122098
37Neurotrophin signaling pathway_Homo sapiens_hsa047221.17080202
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.16222972
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.15615530
40Gap junction_Homo sapiens_hsa045401.15200382
41Type II diabetes mellitus_Homo sapiens_hsa049301.13249119
42mRNA surveillance pathway_Homo sapiens_hsa030151.12267154
43Renal cell carcinoma_Homo sapiens_hsa052111.11957668
44Lysine degradation_Homo sapiens_hsa003101.11811912
45Non-small cell lung cancer_Homo sapiens_hsa052231.10461558
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.10198726
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08798747
48Basal cell carcinoma_Homo sapiens_hsa052171.08717427
49Endometrial cancer_Homo sapiens_hsa052131.08566177
50Axon guidance_Homo sapiens_hsa043601.07803734
51Melanoma_Homo sapiens_hsa052181.07768476
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07619509
53Renin secretion_Homo sapiens_hsa049241.04172614
54Colorectal cancer_Homo sapiens_hsa052101.03160717
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02960573
56Hedgehog signaling pathway_Homo sapiens_hsa043401.02953058
57Cocaine addiction_Homo sapiens_hsa050301.02686285
58Nitrogen metabolism_Homo sapiens_hsa009101.00340384
59Prolactin signaling pathway_Homo sapiens_hsa049171.00105576
60Focal adhesion_Homo sapiens_hsa045100.99948640
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98566095
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97956864
63Choline metabolism in cancer_Homo sapiens_hsa052310.97370657
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.97045587
65MAPK signaling pathway_Homo sapiens_hsa040100.96919578
66cAMP signaling pathway_Homo sapiens_hsa040240.93229139
67Chronic myeloid leukemia_Homo sapiens_hsa052200.92955567
68Circadian rhythm_Homo sapiens_hsa047100.92711859
69Fatty acid biosynthesis_Homo sapiens_hsa000610.92142100
70Cell cycle_Homo sapiens_hsa041100.91180105
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90218054
72Dilated cardiomyopathy_Homo sapiens_hsa054140.87272264
73Small cell lung cancer_Homo sapiens_hsa052220.86830679
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86257827
75Bladder cancer_Homo sapiens_hsa052190.86014362
76Type I diabetes mellitus_Homo sapiens_hsa049400.85115026
77Inositol phosphate metabolism_Homo sapiens_hsa005620.84362959
78Thyroid cancer_Homo sapiens_hsa052160.82623348
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.80614742
80Endocytosis_Homo sapiens_hsa041440.79805518
81Pancreatic cancer_Homo sapiens_hsa052120.79086229
82Pathways in cancer_Homo sapiens_hsa052000.78814203
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78777454
84Calcium signaling pathway_Homo sapiens_hsa040200.78458014
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78238743
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77867672
87ECM-receptor interaction_Homo sapiens_hsa045120.77565601
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77070973
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76773296
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75475446
91Insulin signaling pathway_Homo sapiens_hsa049100.75434551
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75132532
93Melanogenesis_Homo sapiens_hsa049160.74954133
94Serotonergic synapse_Homo sapiens_hsa047260.74334105
95Taste transduction_Homo sapiens_hsa047420.73432666
96Tight junction_Homo sapiens_hsa045300.68466555
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67640029
98Glucagon signaling pathway_Homo sapiens_hsa049220.66776252
99Hippo signaling pathway_Homo sapiens_hsa043900.66761805
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64519742
101Non-homologous end-joining_Homo sapiens_hsa034500.63630749
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62980529
103Acute myeloid leukemia_Homo sapiens_hsa052210.61536440
104MicroRNAs in cancer_Homo sapiens_hsa052060.61337232
105Vibrio cholerae infection_Homo sapiens_hsa051100.61322489
106Vitamin B6 metabolism_Homo sapiens_hsa007500.61016975
107Notch signaling pathway_Homo sapiens_hsa043300.59871742
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59859646
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.59408315
110Rap1 signaling pathway_Homo sapiens_hsa040150.58902045
111Chemokine signaling pathway_Homo sapiens_hsa040620.58450107
112HIF-1 signaling pathway_Homo sapiens_hsa040660.58441088
113p53 signaling pathway_Homo sapiens_hsa041150.58232758
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57649003
115Ras signaling pathway_Homo sapiens_hsa040140.57417059
116Amoebiasis_Homo sapiens_hsa051460.57209538
117Basal transcription factors_Homo sapiens_hsa030220.57203575
118Prion diseases_Homo sapiens_hsa050200.57175063
119FoxO signaling pathway_Homo sapiens_hsa040680.56103912
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55566314
121Arginine biosynthesis_Homo sapiens_hsa002200.55343806
122T cell receptor signaling pathway_Homo sapiens_hsa046600.54787030
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54441988
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53480750
125B cell receptor signaling pathway_Homo sapiens_hsa046620.53291860
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53105037
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.52445949
128RNA degradation_Homo sapiens_hsa030180.52253174
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51164726
130AMPK signaling pathway_Homo sapiens_hsa041520.50544706
131Adherens junction_Homo sapiens_hsa045200.48822821
132Thyroid hormone synthesis_Homo sapiens_hsa049180.48207483
133Alcoholism_Homo sapiens_hsa050340.47175196

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