ATM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.35313533
2negative regulation of cell killing (GO:0031342)6.35313533
3nuclear pore complex assembly (GO:0051292)6.34017434
4regulation of B cell receptor signaling pathway (GO:0050855)6.13163651
5nuclear pore organization (GO:0006999)5.94598725
6negative T cell selection (GO:0043383)5.88658471
7negative thymic T cell selection (GO:0045060)5.72470587
8regulation of gamma-delta T cell differentiation (GO:0045586)5.49874244
9positive T cell selection (GO:0043368)5.47730992
10mitotic sister chromatid cohesion (GO:0007064)5.29408412
11regulation of gamma-delta T cell activation (GO:0046643)5.26490680
12positive thymic T cell selection (GO:0045059)5.05206557
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.01396518
14pore complex assembly (GO:0046931)4.77802961
15activated T cell proliferation (GO:0050798)4.70167658
16B cell receptor signaling pathway (GO:0050853)4.70111233
17DNA unwinding involved in DNA replication (GO:0006268)4.62252473
18positive regulation of granulocyte differentiation (GO:0030854)4.58271195
19T cell selection (GO:0045058)4.47726349
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.47396023
21mitotic chromosome condensation (GO:0007076)4.38967108
22response to interleukin-15 (GO:0070672)4.32802516
23regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.30996178
24negative regulation of T cell mediated immunity (GO:0002710)4.29326230
25antigen processing and presentation of endogenous antigen (GO:0019883)4.23687522
26histone H3-K36 demethylation (GO:0070544)4.22082398
27thymic T cell selection (GO:0045061)4.14188620
28regulation of histone H3-K9 methylation (GO:0051570)4.10586869
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.09851937
30T cell migration (GO:0072678)4.09068699
31regulation of RNA export from nucleus (GO:0046831)4.08581647
32cellular response to ethanol (GO:0071361)4.08580901
33pre-miRNA processing (GO:0031054)4.06970073
34negative regulation of histone methylation (GO:0031061)4.03210246
35microglial cell activation (GO:0001774)4.02330501
36protein localization to kinetochore (GO:0034501)4.01659487
37DNA duplex unwinding (GO:0032508)4.00007744
38DNA geometric change (GO:0032392)3.99779956
39cellular extravasation (GO:0045123)3.96645915
40cellular response to interleukin-15 (GO:0071350)3.95514575
41mitotic nuclear envelope disassembly (GO:0007077)3.93900021
42hepatocyte apoptotic process (GO:0097284)3.90148729
43regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.88936938
44* phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.84156334
45regulation of B cell differentiation (GO:0045577)3.82986200
46negative regulation of lymphocyte mediated immunity (GO:0002707)3.82483513
47positive regulation by symbiont of host defense response (GO:0052509)3.80655799
48modulation by symbiont of host defense response (GO:0052031)3.80655799
49modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.80655799
50modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.80655799
51positive regulation by organism of defense response of other organism involved in symbiotic interact3.80655799
52modulation by symbiont of host immune response (GO:0052553)3.80655799
53interferon-gamma production (GO:0032609)3.80150471
54kinetochore organization (GO:0051383)3.72662293
55membrane disassembly (GO:0030397)3.70741499
56nuclear envelope disassembly (GO:0051081)3.70741499
57meiotic chromosome segregation (GO:0045132)3.67589815
58histone H3-K4 trimethylation (GO:0080182)3.66330550
59leukocyte aggregation (GO:0070486)3.64206609
60detection of molecule of bacterial origin (GO:0032490)3.62145326
61regulation of DNA endoreduplication (GO:0032875)3.60043155
62dosage compensation (GO:0007549)3.59936433
63macrophage activation involved in immune response (GO:0002281)3.56375835
64regulation of spindle organization (GO:0090224)3.52551770
65chromatin assembly (GO:0031497)3.51000770
66IMP biosynthetic process (GO:0006188)3.50082007
67regulation of alpha-beta T cell proliferation (GO:0046640)3.47621286
68positive regulation of B cell differentiation (GO:0045579)3.47584697
69sister chromatid segregation (GO:0000819)3.47398749
70regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.45919656
71DNA replication-dependent nucleosome organization (GO:0034723)3.45574936
72DNA replication-dependent nucleosome assembly (GO:0006335)3.45574936
73folic acid-containing compound biosynthetic process (GO:0009396)3.41316543
74protein localization to chromosome, centromeric region (GO:0071459)3.37881507
75negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.36093086
76regulation of mitotic spindle organization (GO:0060236)3.33861140
77DNA topological change (GO:0006265)3.31950364
78DNA replication initiation (GO:0006270)3.30468497
79regulation of nucleobase-containing compound transport (GO:0032239)3.29800718
80chromatin remodeling at centromere (GO:0031055)3.28412385
81translesion synthesis (GO:0019985)3.27585835
82negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.27135186
83positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.26631624
84DNA conformation change (GO:0071103)3.26130190
85chromatin assembly or disassembly (GO:0006333)3.24304384
86positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.24029251
87positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.24029251
88positive regulation of mitotic sister chromatid separation (GO:1901970)3.24029251
89regulation of sister chromatid cohesion (GO:0007063)3.23711917
90mitotic metaphase plate congression (GO:0007080)3.22815499
91metaphase plate congression (GO:0051310)3.21241018
92B cell proliferation (GO:0042100)3.20749108
93CENP-A containing nucleosome assembly (GO:0034080)3.20734087
94antigen receptor-mediated signaling pathway (GO:0050851)3.19378710
95mitotic recombination (GO:0006312)3.19197526
96positive regulation of alpha-beta T cell proliferation (GO:0046641)3.18972834
97detection of other organism (GO:0098543)3.16252619
98regulation of granulocyte differentiation (GO:0030852)3.16226135
99positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.15625056
100negative regulation of leukocyte mediated immunity (GO:0002704)3.15196858
101DNA replication-independent nucleosome organization (GO:0034724)3.14995930
102DNA replication-independent nucleosome assembly (GO:0006336)3.14995930
103sister chromatid cohesion (GO:0007062)3.14627896
104regulation of helicase activity (GO:0051095)3.13621379
105negative regulation of DNA-dependent DNA replication (GO:2000104)3.13366576
106monoubiquitinated protein deubiquitination (GO:0035520)3.11724636
107detection of external biotic stimulus (GO:0098581)3.10902556
108positive regulation of chromosome segregation (GO:0051984)3.10032346
109DNA strand elongation involved in DNA replication (GO:0006271)3.08366369
110positive regulation of gamma-delta T cell activation (GO:0046645)3.07848103
111antigen processing and presentation via MHC class Ib (GO:0002475)3.06789166
112antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.05320834
113somatic diversification of immune receptors via somatic mutation (GO:0002566)3.01380052
114somatic hypermutation of immunoglobulin genes (GO:0016446)3.01380052
115negative regulation of adaptive immune response (GO:0002820)3.00520398
116regulation of necroptotic process (GO:0060544)2.99955196
117regulation of centriole replication (GO:0046599)2.99392149
118macrophage activation (GO:0042116)2.99295605
119DNA strand elongation (GO:0022616)2.98951751
120IMP metabolic process (GO:0046040)2.97456773
121attachment of spindle microtubules to kinetochore (GO:0008608)2.96497992
122T cell proliferation (GO:0042098)2.96356850
123T cell receptor signaling pathway (GO:0050852)2.96351453
124mitotic sister chromatid segregation (GO:0000070)2.95638456
125telomere maintenance via semi-conservative replication (GO:0032201)2.95418759
126telomere maintenance via recombination (GO:0000722)2.94063634
127positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.93985674
128regulation of interferon-beta biosynthetic process (GO:0045357)2.93265121
129regulation of regulatory T cell differentiation (GO:0045589)2.92563382
130protein K6-linked ubiquitination (GO:0085020)2.92494219
131maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.92010862
132* histone mRNA catabolic process (GO:0071044)2.91976866
133DNA synthesis involved in DNA repair (GO:0000731)2.91803674
134peptidyl-lysine trimethylation (GO:0018023)2.91232270
135myeloid leukocyte mediated immunity (GO:0002444)2.90502406
136establishment of chromosome localization (GO:0051303)2.88461898
137establishment of protein localization to Golgi (GO:0072600)2.87816184
138replication fork processing (GO:0031297)2.86028482
139mismatch repair (GO:0006298)2.85901623
140regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.85467651
141* telomere maintenance (GO:0000723)2.84813637
142regulation of isotype switching to IgG isotypes (GO:0048302)2.83356737
143resolution of meiotic recombination intermediates (GO:0000712)2.83251704
144regulation of beta-amyloid formation (GO:1902003)2.83240521
145protein K48-linked deubiquitination (GO:0071108)2.82554609
146neutrophil mediated immunity (GO:0002446)2.82545883
147nuclear envelope organization (GO:0006998)2.82313272
148histone H2A monoubiquitination (GO:0035518)2.82241411
149negative regulation of DNA repair (GO:0045738)2.81892619
150* telomere organization (GO:0032200)2.81242898
151postreplication repair (GO:0006301)2.80837042
152histone exchange (GO:0043486)2.79723132
153detection of bacterium (GO:0016045)2.79647944
154protein localization to chromosome (GO:0034502)2.79557935
155myeloid cell activation involved in immune response (GO:0002275)2.79216751
156positive regulation of humoral immune response (GO:0002922)2.78586300
157negative regulation of interleukin-12 production (GO:0032695)2.78383652
158DNA replication checkpoint (GO:0000076)2.77833756
159kinetochore assembly (GO:0051382)2.77433288
160chromosome condensation (GO:0030261)2.77294008
161heterochromatin organization (GO:0070828)2.76843583
162regulation of MHC class I biosynthetic process (GO:0045343)2.76742245
163ATP-dependent chromatin remodeling (GO:0043044)2.76449004
164DNA packaging (GO:0006323)2.76241075
165alpha-beta T cell differentiation (GO:0046632)2.75406580
166B cell homeostasis (GO:0001782)2.75022720
167mRNA transport (GO:0051028)2.74370494
168mast cell activation (GO:0045576)2.74016285
169alpha-beta T cell activation (GO:0046631)2.73253480
170chromosome segregation (GO:0007059)2.72055310
171regulation of centrosome cycle (GO:0046605)2.71526055
172regulation of T cell tolerance induction (GO:0002664)2.71386647
173cytoplasmic mRNA processing body assembly (GO:0033962)2.71225296
174histone H3-K9 demethylation (GO:0033169)2.71070855
175regulation of histone methylation (GO:0031060)2.70572383
176positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.70451686
177detection of biotic stimulus (GO:0009595)2.70445570
178regulation of tolerance induction (GO:0002643)2.70443648
179response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.68982151
180response to host immune response (GO:0052572)2.68982151
181nucleobase biosynthetic process (GO:0046112)2.68647929
182negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.68303405
183negative regulation of T-helper cell differentiation (GO:0045623)2.68303405
184positive regulation of histone H3-K4 methylation (GO:0051571)2.68166084
185response to UV-C (GO:0010225)2.68103566
186protein targeting to Golgi (GO:0000042)2.66928672
187negative regulation of histone modification (GO:0031057)2.66786988
188alternative mRNA splicing, via spliceosome (GO:0000380)2.66354240
189RNA stabilization (GO:0043489)2.66304015
190mRNA stabilization (GO:0048255)2.66304015
191natural killer cell differentiation (GO:0001779)2.66149880
192nucleotide-excision repair, DNA gap filling (GO:0006297)2.65079249
193telomere maintenance via telomere lengthening (GO:0010833)2.65019390
194T cell homeostasis (GO:0043029)2.64883584
195interkinetic nuclear migration (GO:0022027)2.63755733
196tolerance induction (GO:0002507)2.63318293
197protein K11-linked deubiquitination (GO:0035871)2.61751195

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.02715830
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.57136002
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.26202261
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.63890038
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.22455047
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.96974233
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91128684
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.80952498
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.56609250
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.48526425
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.47926113
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.47648305
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.38605691
14MYC_22102868_ChIP-Seq_BL_Human2.25810053
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.25274111
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04063867
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.02747966
18E2F7_22180533_ChIP-Seq_HELA_Human11.5684124
19AR_21909140_ChIP-Seq_LNCAP_Human1.95395398
20GATA3_27048872_Chip-Seq_THYMUS_Human1.94583110
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.89233847
22ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.86472668
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.84890050
24* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83826269
25TP63_19390658_ChIP-ChIP_HaCaT_Human1.78773507
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.78755852
27CIITA_25753668_ChIP-Seq_RAJI_Human1.78482825
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.77861153
29* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77816090
30* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77062252
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.74570127
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.73406632
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69104258
34VDR_24787735_ChIP-Seq_THP-1_Human1.68037760
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67881947
36SPI1_23127762_ChIP-Seq_K562_Human1.64901116
37ELK1_19687146_ChIP-ChIP_HELA_Human1.62775879
38GATA3_26560356_Chip-Seq_TH2_Human1.56762505
39VDR_23849224_ChIP-Seq_CD4+_Human1.56471958
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.54334006
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51827694
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46551580
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46060800
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45619124
45FOXP3_21729870_ChIP-Seq_TREG_Human1.44648742
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44600096
47* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.42019613
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.38849123
49KDM5A_27292631_Chip-Seq_BREAST_Human1.38252528
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38046249
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38020621
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37071359
53* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36395415
54PU_27001747_Chip-Seq_BMDM_Mouse1.36216470
55PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35670709
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.33966693
57MYB_26560356_Chip-Seq_TH1_Human1.33347397
58FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33030725
59MYB_26560356_Chip-Seq_TH2_Human1.32638329
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31886683
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30216995
62* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29819936
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27089696
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26716590
65AR_21572438_ChIP-Seq_LNCaP_Human1.26484508
66EST1_17652178_ChIP-ChIP_JURKAT_Human1.26042823
67PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25207064
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25039032
69NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.24420540
70* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24410830
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20737340
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.20494926
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20092851
74* XRN2_22483619_ChIP-Seq_HELA_Human1.19100352
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18149846
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17534282
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16243894
78* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16029645
79* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15926165
80GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15261948
81IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14415168
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12421552
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10523879
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10351380
85VDR_24763502_ChIP-Seq_THP-1_Human1.10149191
86* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08969345
87* TFEB_21752829_ChIP-Seq_HELA_Human1.08229249
88GATA1_19941827_ChIP-Seq_MEL_Mouse1.06656817
89* TP53_16413492_ChIP-PET_HCT116_Human1.05914728
90EZH2_27294783_Chip-Seq_NPCs_Mouse1.05838586
91ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05836918
92SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.05258694
93NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03444244
94FOXO3_23340844_ChIP-Seq_DLD1_Human1.02955100
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02929851
96RUNX1_22412390_ChIP-Seq_EML_Mouse1.02102940
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.01554967
98MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01114688
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01081163
100SPI1_23547873_ChIP-Seq_NB4_Human1.01046101
101SMRT_27268052_Chip-Seq_Bcells_Human1.00991162
102VDR_21846776_ChIP-Seq_THP-1_Human1.00956645
103STAT3_23295773_ChIP-Seq_U87_Human1.00857041
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00165411
105UTX_26944678_Chip-Seq_JUKART_Human0.99303685
106HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99253050
107* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98401224
108OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97910640
109NFE2_27457419_Chip-Seq_LIVER_Mouse0.97299711
110TCF7_22412390_ChIP-Seq_EML_Mouse0.97065336
111* CREB1_15753290_ChIP-ChIP_HEK293T_Human0.96868041
112STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96760364
113MAF_26560356_Chip-Seq_TH1_Human0.96656083
114FLI1_21867929_ChIP-Seq_TH2_Mouse0.96210222
115* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95959996
116SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95377827
117* GATA2_19941826_ChIP-Seq_K562_Human0.94484555
118ER_23166858_ChIP-Seq_MCF-7_Human0.94298418
119TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94135968
120GATA1_19941826_ChIP-Seq_K562_Human0.94081784
121GABP_17652178_ChIP-ChIP_JURKAT_Human0.93385015
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93265403
123GATA2_21666600_ChIP-Seq_HMVEC_Human0.93072674
124KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.92683813
125TAF15_26573619_Chip-Seq_HEK293_Human0.91912301
126PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91643345
127GATA1_22025678_ChIP-Seq_K562_Human0.91291349
128KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90510783
129GABP_19822575_ChIP-Seq_HepG2_Human0.89491164
130MAF_26560356_Chip-Seq_TH2_Human0.89089365
131BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87150722
132TTF2_22483619_ChIP-Seq_HELA_Human0.86641542
133MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86440613
134OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86042341
135TCF4_23295773_ChIP-Seq_U87_Human0.85493604
136MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85309617
137ETS1_20019798_ChIP-Seq_JURKAT_Human0.84040467
138PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83779712
139CHD1_26751641_Chip-Seq_LNCaP_Human0.83499807
140TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83175630
141CRX_20693478_ChIP-Seq_RETINA_Mouse0.82803027
142SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.82550960
143NANOG_18555785_Chip-Seq_ESCs_Mouse0.81884034
144ARNT_22903824_ChIP-Seq_MCF-7_Human0.81747785
145GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81644662
146IRF8_21731497_ChIP-ChIP_J774_Mouse0.81511421
147E2F1_18555785_ChIP-Seq_MESCs_Mouse0.81463469
148ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81454881
149RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81186557
150BRD4_27068464_Chip-Seq_AML-cells_Mouse0.81089896
151CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80634154
152GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80165316
153NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.79974324
154TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79946215
155POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.79946215
156E2F1_18555785_Chip-Seq_ESCs_Mouse0.79917427
157GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79872393
158SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.79667000
159RUNX_20019798_ChIP-Seq_JUKART_Human0.79494246
160KLF4_18555785_ChIP-Seq_MESCs_Mouse0.79051727
161FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.78545062
162SCL_19346495_ChIP-Seq_HPC-7_Human0.77866702
163CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.77288993
164DCP1A_22483619_ChIP-Seq_HELA_Human0.76518350
165NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.76404120

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0010094_abnormal_chromosome_stability3.81928242
2MP0008057_abnormal_DNA_replication3.80802962
3MP0003693_abnormal_embryo_hatching3.59741559
4* MP0003111_abnormal_nucleus_morphology3.16383699
5MP0000569_abnormal_digit_pigmentation3.15971017
6MP0003724_increased_susceptibility_to3.07818342
7* MP0003077_abnormal_cell_cycle3.07715312
8MP0010352_gastrointestinal_tract_polyps2.99793739
9MP0002396_abnormal_hematopoietic_system2.83701371
10MP0004381_abnormal_hair_follicle2.78232427
11MP0010307_abnormal_tumor_latency2.75631178
12MP0008058_abnormal_DNA_repair2.68447585
13MP0004957_abnormal_blastocyst_morpholog2.62134311
14MP0008877_abnormal_DNA_methylation2.42420125
15MP0008260_abnormal_autophagy2.37300106
16MP0003436_decreased_susceptibility_to2.33922936
17MP0004808_abnormal_hematopoietic_stem2.25083094
18MP0008007_abnormal_cellular_replicative2.16018876
19MP0002166_altered_tumor_susceptibility2.14150392
20MP0005075_abnormal_melanosome_morpholog2.10073582
21MP0003303_peritoneal_inflammation2.09071130
22MP0005076_abnormal_cell_differentiation2.04218686
23* MP0002419_abnormal_innate_immunity1.98948128
24* MP0003763_abnormal_thymus_physiology1.98695048
25MP0005025_abnormal_response_to1.98581921
26MP0003123_paternal_imprinting1.91746188
27MP0003121_genomic_imprinting1.88784372
28MP0003172_abnormal_lysosome_physiology1.88004087
29MP0002877_abnormal_melanocyte_morpholog1.87013081
30MP0001730_embryonic_growth_arrest1.85381496
31* MP0000350_abnormal_cell_proliferation1.82780316
32MP0003890_abnormal_embryonic-extraembry1.82108654
33MP0005310_abnormal_salivary_gland1.78913231
34MP0002006_tumorigenesis1.77732634
35MP0002009_preneoplasia1.75058311
36MP0004883_abnormal_blood_vessel1.73246127
37MP0003787_abnormal_imprinting1.68853405
38MP0003300_gastrointestinal_ulcer1.63870091
39MP0005464_abnormal_platelet_physiology1.61745346
40MP0009785_altered_susceptibility_to1.57662010
41MP0003656_abnormal_erythrocyte_physiolo1.55660857
42MP0006082_CNS_inflammation1.54876595
43* MP0005380_embryogenesis_phenotype1.53709452
44* MP0001672_abnormal_embryogenesis/_devel1.53709452
45* MP0002398_abnormal_bone_marrow1.51611857
46* MP0000703_abnormal_thymus_morphology1.49579126
47MP0002086_abnormal_extraembryonic_tissu1.49227581
48MP0004197_abnormal_fetal_growth/weight/1.48897842
49MP0001835_abnormal_antigen_presentation1.48124717
50MP0000490_abnormal_crypts_of1.43308182
51MP0002084_abnormal_developmental_patter1.42631916
52MP0008932_abnormal_embryonic_tissue1.42569213
53* MP0003984_embryonic_growth_retardation1.39714483
54* MP0001800_abnormal_humoral_immune1.38334141
55* MP0002088_abnormal_embryonic_growth/wei1.38161979
56MP0003828_pulmonary_edema1.38030163
57MP0001697_abnormal_embryo_size1.36425883
58MP0001851_eye_inflammation1.35405448
59MP0000371_diluted_coat_color1.31684331
60MP0005671_abnormal_response_to1.31028687
61MP0003786_premature_aging1.29489023
62MP0004130_abnormal_muscle_cell1.28203921
63* MP0002019_abnormal_tumor_incidence1.24719367
64MP0001845_abnormal_inflammatory_respons1.24507155
65* MP0002080_prenatal_lethality1.23485796
66* MP0002085_abnormal_embryonic_tissue1.23072345
67MP0000689_abnormal_spleen_morphology1.21452701
68* MP0002722_abnormal_immune_system1.19910244
69MP0001293_anophthalmia1.19727408
70MP0009278_abnormal_bone_marrow1.19005393
71MP0005451_abnormal_body_composition1.14837645
72MP0005174_abnormal_tail_pigmentation1.14588787
73MP0010234_abnormal_vibrissa_follicle1.11923075
74* MP0000313_abnormal_cell_death1.11416626
75MP0003221_abnormal_cardiomyocyte_apopto1.10631505
76* MP0000716_abnormal_immune_system1.09014573
77* MP0002452_abnormal_antigen_presenting1.08253939
78MP0005397_hematopoietic_system_phenotyp1.08230781
79MP0001545_abnormal_hematopoietic_system1.08230781
80MP0009703_decreased_birth_body1.07416047
81MP0000685_abnormal_immune_system1.07273402
82* MP0002420_abnormal_adaptive_immunity1.06637185
83* MP0001819_abnormal_immune_cell1.03871717
84MP0003045_fibrosis1.02564185
85MP0002148_abnormal_hypersensitivity_rea1.02163295
86MP0003566_abnormal_cell_adhesion1.00539628
87* MP0002429_abnormal_blood_cell0.99554058
88MP0002998_abnormal_bone_remodeling0.99301945
89MP0005164_abnormal_response_to0.98959717
90MP0001533_abnormal_skeleton_physiology0.98768208
91MP0001790_abnormal_immune_system0.98701279
92MP0005387_immune_system_phenotype0.98701279
93MP0001873_stomach_inflammation0.97300026
94MP0000733_abnormal_muscle_development0.97146080
95* MP0002723_abnormal_immune_serum0.96862439
96MP0000858_altered_metastatic_potential0.96452957
97MP0003183_abnormal_peptide_metabolism0.95964811
98MP0005408_hypopigmentation0.95128920
99MP0002933_joint_inflammation0.94713578
100MP0003705_abnormal_hypodermis_morpholog0.93723616
101MP0004484_altered_response_of0.92112181
102MP0002095_abnormal_skin_pigmentation0.91325029
103MP0002075_abnormal_coat/hair_pigmentati0.89470763
104MP0003567_abnormal_fetal_cardiomyocyte0.89232965
105MP0010155_abnormal_intestine_physiology0.88756233
106MP0009672_abnormal_birth_weight0.87425148
107MP0006054_spinal_hemorrhage0.87076471
108MP0000428_abnormal_craniofacial_morphol0.86586002
109MP0009333_abnormal_splenocyte_physiolog0.85813430
110* MP0005621_abnormal_cell_physiology0.85497893
111MP0002332_abnormal_exercise_endurance0.83336601
112MP0002092_abnormal_eye_morphology0.83048717
113MP0002405_respiratory_system_inflammati0.82334148
114MP0001986_abnormal_taste_sensitivity0.82152329
115MP0003937_abnormal_limbs/digits/tail_de0.81533517
116MP0000427_abnormal_hair_cycle0.81088703
117MP0001915_intracranial_hemorrhage0.79551619
118MP0005000_abnormal_immune_tolerance0.77808874
119MP0003935_abnormal_craniofacial_develop0.77182244
120* MP0002210_abnormal_sex_determination0.77008837
121MP0001186_pigmentation_phenotype0.76889927
122* MP0005384_cellular_phenotype0.75213728
123MP0002928_abnormal_bile_duct0.74878584
124MP0008469_abnormal_protein_level0.74020759
125MP0002925_abnormal_cardiovascular_devel0.73860714
126MP0004947_skin_inflammation0.73480962
127MP0003866_abnormal_defecation0.73466241
128MP0003943_abnormal_hepatobiliary_system0.72310076
129MP0000015_abnormal_ear_pigmentation0.72274010
130MP0008961_abnormal_basal_metabolism0.72273685
131MP0000604_amyloidosis0.72224482
132MP0000465_gastrointestinal_hemorrhage0.71553230
133MP0001853_heart_inflammation0.70628147
134MP0004264_abnormal_extraembryonic_tissu0.69787262
135* MP0001145_abnormal_male_reproductive0.69384701
136MP0009115_abnormal_fat_cell0.69067707
137MP0000249_abnormal_blood_vessel0.68907179
138MP0000432_abnormal_head_morphology0.67645096
139MP0005023_abnormal_wound_healing0.67509249
140MP0003091_abnormal_cell_migration0.65442464
141MP0000372_irregular_coat_pigmentation0.64672042
142MP0001958_emphysema0.62767727
143MP0003632_abnormal_nervous_system0.62536487
144MP0002168_other_aberrant_phenotype0.60982486
145* MP0003690_abnormal_glial_cell0.57579578
146MP0003252_abnormal_bile_duct0.57284490
147MP0005376_homeostasis/metabolism_phenot0.56499036
148MP0009764_decreased_sensitivity_to0.54479875
149MP0005409_darkened_coat_color0.54461179
150MP0002133_abnormal_respiratory_system0.54306595

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)4.95017016
2Eczematoid dermatitis (HP:0000976)4.69527953
3Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.53663864
4Recurrent fungal infections (HP:0002841)4.30673008
5Recurrent abscess formation (HP:0002722)4.23410480
6Abnormality of the fingertips (HP:0001211)4.09922990
7Chromsome breakage (HP:0040012)4.07608535
8Volvulus (HP:0002580)4.04605730
9Recurrent cutaneous fungal infections (HP:0011370)3.89692778
10Chronic mucocutaneous candidiasis (HP:0002728)3.89692778
11Spontaneous hematomas (HP:0007420)3.72598876
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.61323063
13Panhypogammaglobulinemia (HP:0003139)3.58573575
14Colitis (HP:0002583)3.51057934
15Recurrent skin infections (HP:0001581)3.50614027
16Gastrointestinal infarctions (HP:0005244)3.47779446
17Optic neuritis (HP:0100653)3.39740021
18Retrobulbar optic neuritis (HP:0100654)3.39740021
19Myositis (HP:0100614)3.37446862
20Medulloblastoma (HP:0002885)3.26367964
21Stomatitis (HP:0010280)3.11646127
22Meningitis (HP:0001287)3.11048038
23Ependymoma (HP:0002888)3.09613114
24Mediastinal lymphadenopathy (HP:0100721)3.07800108
25Orchitis (HP:0100796)3.04803780
26Gingivitis (HP:0000230)3.04438840
27Inflammation of the large intestine (HP:0002037)3.04036571
28Pustule (HP:0200039)3.03089194
29* Abnormality of chromosome stability (HP:0003220)3.00981357
30Leukocytosis (HP:0001974)2.98661341
31Severe combined immunodeficiency (HP:0004430)2.97518824
32Elevated erythrocyte sedimentation rate (HP:0003565)2.96307263
33Colon cancer (HP:0003003)2.91662492
34Encephalitis (HP:0002383)2.88757906
35Vasculitis (HP:0002633)2.88430216
36Abnormality of eosinophils (HP:0001879)2.87341752
37Recurrent gram-negative bacterial infections (HP:0005420)2.83047723
38Gastrointestinal inflammation (HP:0004386)2.81929733
39Eosinophilia (HP:0001880)2.79882113
40Ectopic kidney (HP:0000086)2.79353943
41Short 4th metacarpal (HP:0010044)2.76235488
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.76235488
43Gingival bleeding (HP:0000225)2.75306388
44Prominent nose (HP:0000448)2.72742917
45Agammaglobulinemia (HP:0004432)2.66539067
46Slow saccadic eye movements (HP:0000514)2.65025922
47Long eyelashes (HP:0000527)2.64884256
48Abnormality of the astrocytes (HP:0100707)2.63644751
49Astrocytoma (HP:0009592)2.63644751
50Rhabdomyosarcoma (HP:0002859)2.63578194
51Autoimmune hemolytic anemia (HP:0001890)2.62951156
52Myelodysplasia (HP:0002863)2.58604186
53Granulocytopenia (HP:0001913)2.57195915
54Hematochezia (HP:0002573)2.54229145
55Chest pain (HP:0100749)2.53993975
56Papilloma (HP:0012740)2.50741312
57Verrucae (HP:0200043)2.50741312
58IgM deficiency (HP:0002850)2.50229481
59Keratoconjunctivitis sicca (HP:0001097)2.49145097
60Genetic anticipation (HP:0003743)2.46886573
61* T lymphocytopenia (HP:0005403)2.46834343
62Glioma (HP:0009733)2.43596684
63Papilledema (HP:0001085)2.39997983
64Recurrent viral infections (HP:0004429)2.39641524
65Hemoptysis (HP:0002105)2.39382347
66Neoplasm of the oral cavity (HP:0100649)2.39325684
67Deep philtrum (HP:0002002)2.39068692
68Acute myeloid leukemia (HP:0004808)2.38510241
69Arterial thrombosis (HP:0004420)2.38332085
70Biliary tract neoplasm (HP:0100574)2.37096978
71Basal cell carcinoma (HP:0002671)2.37065541
72Birth length less than 3rd percentile (HP:0003561)2.36855021
73Abnormality of T cell physiology (HP:0011840)2.34657004
74Aplasia/Hypoplasia of the uvula (HP:0010293)2.34289129
75Keratoconjunctivitis (HP:0001096)2.34136231
76Abnormality of macrophages (HP:0004311)2.33406070
77Deviation of the thumb (HP:0009603)2.33217615
78* Abnormality of T cell number (HP:0011839)2.31621486
79Macroorchidism (HP:0000053)2.30135566
80Epistaxis (HP:0000421)2.29864965
81Impulsivity (HP:0100710)2.29489041
82Increased nuchal translucency (HP:0010880)2.29106049
83Cellulitis (HP:0100658)2.29069224
84Amaurosis fugax (HP:0100576)2.28909625
85Abnormality of the preputium (HP:0100587)2.28225302
8611 pairs of ribs (HP:0000878)2.28042824
87Combined immunodeficiency (HP:0005387)2.27627888
88Heterotopia (HP:0002282)2.27256865
89Proximal placement of thumb (HP:0009623)2.27172796
90Prolonged bleeding time (HP:0003010)2.25825891
91Periodontitis (HP:0000704)2.25136928
92Truncal obesity (HP:0001956)2.25011177
93Pulmonary infiltrates (HP:0002113)2.24985758
94High pitched voice (HP:0001620)2.24692229
95Subacute progressive viral hepatitis (HP:0006572)2.24491985
96Meckel diverticulum (HP:0002245)2.23920839
97Stomach cancer (HP:0012126)2.23254719
98Absent frontal sinuses (HP:0002688)2.17065381
99Sandal gap (HP:0001852)2.15187564
100Urethral obstruction (HP:0000796)2.13536265
101Cutaneous melanoma (HP:0012056)2.13208381
102Dislocated radial head (HP:0003083)2.11502913
103Hemiplegia (HP:0002301)2.10259770
104Neoplasm of striated muscle (HP:0009728)2.10159970
105Abnormality of the ileum (HP:0001549)2.08474948
106Abnormality of the carotid arteries (HP:0005344)2.08178502
107Agnosia (HP:0010524)2.07369524
108Selective tooth agenesis (HP:0001592)2.06027766
109Pulmonary embolism (HP:0002204)2.05899613
110Abnormal delayed hypersensitivity skin test (HP:0002963)2.04712308
111Anal stenosis (HP:0002025)2.04409450
112* Cafe-au-lait spot (HP:0000957)2.04238681
113Neoplasm of the tracheobronchial system (HP:0100552)2.02445106
114Abnormality of the labia minora (HP:0012880)2.01248961
115Peritonitis (HP:0002586)2.00238036
116Osteomyelitis (HP:0002754)2.00190218
117* Lymphoma (HP:0002665)1.98381274
118Gastrointestinal carcinoma (HP:0002672)1.96799073
119Malignant gastrointestinal tract tumors (HP:0006749)1.96799073
120Narrow palate (HP:0000189)1.95768323
121Postural instability (HP:0002172)1.95548985
122Sloping forehead (HP:0000340)1.95548873
123* Lymphopenia (HP:0001888)1.95187418
124Neonatal hypoglycemia (HP:0001998)1.92632722
125Low anterior hairline (HP:0000294)1.92609057
126Abnormality of the radial head (HP:0003995)1.91523171
127Obstructive lung disease (HP:0006536)1.89514795
128Chronic obstructive pulmonary disease (HP:0006510)1.89514795
129* Abnormality of cells of the lymphoid lineage (HP:0012140)1.87367574
130Acute hepatic failure (HP:0006554)1.86044925
131* Recurrent bronchitis (HP:0002837)1.85828653
132Abnormality of the peritoneum (HP:0002585)1.85773837
133Duodenal stenosis (HP:0100867)1.85677682
134Small intestinal stenosis (HP:0012848)1.85677682
135Lip pit (HP:0100267)1.85376619
136Bone marrow hypocellularity (HP:0005528)1.85183419
137Thrombocytosis (HP:0001894)1.84794617
138* Abnormality of T cells (HP:0002843)1.83833258
139Abnormality of DNA repair (HP:0003254)1.83527725
140Papillary thyroid carcinoma (HP:0002895)1.82277267
141Facial hemangioma (HP:0000329)1.81879758
142Clubbing of toes (HP:0100760)1.81834158
143Thyroiditis (HP:0100646)1.79067427
144Fatigue (HP:0012378)1.78934544
145Trigonocephaly (HP:0000243)1.78569682
146Abnormality of B cell number (HP:0010975)1.75434437
147Leukopenia (HP:0001882)1.75115394
148Persistence of primary teeth (HP:0006335)1.73421102
149Cutis marmorata (HP:0000965)1.72715887
150Missing ribs (HP:0000921)1.72438893
151Abnormality of the 4th metacarpal (HP:0010012)1.71077579
152Reticulocytopenia (HP:0001896)1.70594622
153Abnormal biliary tract morphology (HP:0012440)1.70474093
154Aplastic anemia (HP:0001915)1.69623248
155Sepsis (HP:0100806)1.69599387
156Hepatitis (HP:0012115)1.69550600
157* IgG deficiency (HP:0004315)1.68868673
158Ocular albinism (HP:0001107)1.68228057
159Entropion (HP:0000621)1.66514358
160Obsessive-compulsive behavior (HP:0000722)1.66152760
161Widely spaced teeth (HP:0000687)1.65929647
162Urticaria (HP:0001025)1.65147631
163Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.65127664
164Abnormality of the pleura (HP:0002103)1.64623411
165Broad palm (HP:0001169)1.64557391
166Duplicated collecting system (HP:0000081)1.64464476
167Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.64256957
168Poikiloderma (HP:0001029)1.64121423
169Hypopigmentation of the fundus (HP:0007894)1.63105174
170Chronic diarrhea (HP:0002028)1.62794795
171Abnormality of the metopic suture (HP:0005556)1.62345481
172Neoplasm of the small intestine (HP:0100833)1.62188886
173Viral hepatitis (HP:0006562)1.62000770
174Abnormality of chromosome segregation (HP:0002916)1.61248831
175Freckling (HP:0001480)1.60933024
176Limited elbow extension (HP:0001377)1.60784274
177Prominent metopic ridge (HP:0005487)1.59830281
178Hypoplasia of the maxilla (HP:0000327)1.59777670
179Squamous cell carcinoma (HP:0002860)1.59015222
180Abnormal platelet volume (HP:0011876)1.57691554

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.29886302
2CDC74.23305801
3RIPK42.94270588
4BLK2.87645478
5EEF2K2.77988768
6NEK22.40194481
7PASK2.27771094
8BRD42.15498452
9WEE12.15249175
10MAP4K12.15022964
11ACVR1B2.04772715
12SRPK12.01020845
13GRK62.00211480
14IKBKE1.93072156
15FES1.92599981
16CAMKK21.89211912
17SYK1.84864735
18* ATR1.84631594
19FRK1.77430968
20SCYL21.72223514
21RPS6KB21.70074715
22TTK1.67259022
23BRSK21.64011683
24ZAK1.62581867
25FGFR31.62164067
26SGK21.59173071
27CAMK1D1.57409769
28JAK31.56553902
29ZAP701.55354023
30CDK41.55154009
31PIK3CG1.53572341
32STK101.52591022
33STK41.49639576
34PRPF4B1.48137945
35FGR1.47467918
36TSSK61.44087722
37TLK11.39809200
38CHEK11.38833982
39MAP3K101.38727949
40IRAK41.38019414
41* AURKB1.36053171
42MAP2K31.32619323
43WNK11.30779275
44* ATM1.28003136
45MELK1.27595771
46CDK61.26935587
47CHEK21.26847096
48PLK11.26509243
49TGFBR11.24028890
50BMPR21.23213689
51PKN21.22376315
52SGK31.21194026
53CDK71.20953528
54MAP3K21.20159293
55MARK21.18502872
56MAP3K141.15244867
57MKNK11.14401870
58NEK91.13818643
59LYN1.13587059
60CDK91.13392152
61NUAK11.11677719
62PLK31.11595554
63YES11.11265957
64STK31.09441521
65JAK21.08300551
66TXK1.08136486
67TYK21.07345498
68ITK1.06132700
69MKNK21.05511018
70PIM11.04623787
71EIF2AK31.01766366
72TGFBR21.01107552
73RPS6KA41.00643292
74CAMK1G0.99086610
75PTK2B0.99061422
76LATS10.99016214
77MAP3K70.96850837
78AKT30.96080687
79MTOR0.95826001
80FGFR40.95818758
81TTN0.95097652
82CDK20.95071774
83PLK40.94068129
84FLT30.92345866
85ALK0.91434803
86CHUK0.91426887
87CAMKK10.89571128
88SGK4940.88497669
89SGK2230.88497669
90JAK10.87912139
91CSF1R0.83850580
92TEC0.83621449
93MAP3K80.83592288
94PDK10.81242411
95TRPM70.78338713
96NEK60.77749854
97MARK30.77542902
98TNK20.77336673
99BTK0.75327844
100FGFR20.74999288
101EIF2AK10.74933926
102CDK10.74255289
103STK110.72643389
104VRK10.72615750
105IRAK10.71586396
106MAPK70.70724985
107NLK0.69291434
108RPS6KB10.68027275
109STK380.67055455
110RPS6KA50.66018152
111PRKCQ0.65285229
112RET0.65037474
113CAMK40.64559006
114CLK10.64434397
115CDC42BPA0.63842807
116EPHA30.63628153
117BUB10.63016691
118HIPK20.62322600
119FGFR10.61707607
120* PRKDC0.60798587
121MAPK110.60413590
122SGK10.60057392
123LCK0.59623449
124PTK60.59343459
125MAPK120.59325813
126PDGFRA0.58517278
127ERBB20.57332211
128MAP3K130.56088790
129MAP3K10.54589389
130MAPK140.54407283
131PDGFRB0.54032087
132KIT0.53657691
133DYRK1A0.53651097
134HCK0.53292397
135TYRO30.52689010
136GRK50.52277791
137TAOK30.52100897
138CSNK1D0.51308506
139KSR20.49564044
140LRRK20.46596328
141NEK10.46519099
142CSK0.45844098
143CSNK2A20.45740688
144RIPK10.45122368
145EPHB10.44901569
146EIF2AK20.44813048
147KSR10.43568700
148AKT10.43046632
149BRSK10.42790574
150FYN0.41956886
151PRKCH0.41152226
152RAF10.40317211
153IKBKB0.40029738
154CSNK1A1L0.39226116
155MAP3K60.37138464
156PAK30.36146380
157SIK20.35829382

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.47532695
2Mismatch repair_Homo sapiens_hsa034303.33840641
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.79984705
4Non-homologous end-joining_Homo sapiens_hsa034502.77599951
5One carbon pool by folate_Homo sapiens_hsa006702.77063165
6* Cell cycle_Homo sapiens_hsa041102.47129469
7RNA transport_Homo sapiens_hsa030132.45793394
8Fanconi anemia pathway_Homo sapiens_hsa034602.42683743
9Homologous recombination_Homo sapiens_hsa034402.29018840
10Spliceosome_Homo sapiens_hsa030402.26571266
11Base excision repair_Homo sapiens_hsa034102.21366048
12Systemic lupus erythematosus_Homo sapiens_hsa053222.18821519
13mRNA surveillance pathway_Homo sapiens_hsa030152.07744261
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.02423488
15Nucleotide excision repair_Homo sapiens_hsa034201.97376618
16Primary immunodeficiency_Homo sapiens_hsa053401.85070991
17Autoimmune thyroid disease_Homo sapiens_hsa053201.79280277
18RNA degradation_Homo sapiens_hsa030181.74001274
19Staphylococcus aureus infection_Homo sapiens_hsa051501.66293877
20Herpes simplex infection_Homo sapiens_hsa051681.61087740
21Antigen processing and presentation_Homo sapiens_hsa046121.59007327
22Viral carcinogenesis_Homo sapiens_hsa052031.55641742
23* NF-kappa B signaling pathway_Homo sapiens_hsa040641.42187220
24Tuberculosis_Homo sapiens_hsa051521.41142980
25Measles_Homo sapiens_hsa051621.37580874
26Lysine degradation_Homo sapiens_hsa003101.35178168
27Dorso-ventral axis formation_Homo sapiens_hsa043201.33323433
28* MicroRNAs in cancer_Homo sapiens_hsa052061.30398324
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29787188
30* p53 signaling pathway_Homo sapiens_hsa041151.28237124
31RNA polymerase_Homo sapiens_hsa030201.27278898
32* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.25637055
33Small cell lung cancer_Homo sapiens_hsa052221.20744932
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.15167073
35* HTLV-I infection_Homo sapiens_hsa051661.13958982
36Pyrimidine metabolism_Homo sapiens_hsa002401.13846375
37B cell receptor signaling pathway_Homo sapiens_hsa046621.12557802
38Renal cell carcinoma_Homo sapiens_hsa052111.11733082
39Basal transcription factors_Homo sapiens_hsa030221.11431948
40Epstein-Barr virus infection_Homo sapiens_hsa051691.11034724
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.11024957
42Chronic myeloid leukemia_Homo sapiens_hsa052201.08639781
43Hepatitis B_Homo sapiens_hsa051611.08157542
44T cell receptor signaling pathway_Homo sapiens_hsa046601.06821986
45Hematopoietic cell lineage_Homo sapiens_hsa046401.04094472
46mTOR signaling pathway_Homo sapiens_hsa041501.03731068
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01979249
48Influenza A_Homo sapiens_hsa051641.01924222
49VEGF signaling pathway_Homo sapiens_hsa043700.99300942
50Choline metabolism in cancer_Homo sapiens_hsa052310.97104508
51Malaria_Homo sapiens_hsa051440.96865744
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96013434
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92549538
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92388022
55Alcoholism_Homo sapiens_hsa050340.91709114
56Asthma_Homo sapiens_hsa053100.91699396
57Glioma_Homo sapiens_hsa052140.89411108
58Colorectal cancer_Homo sapiens_hsa052100.86790479
59Selenocompound metabolism_Homo sapiens_hsa004500.85559903
60Prostate cancer_Homo sapiens_hsa052150.85465417
61Pancreatic cancer_Homo sapiens_hsa052120.84986960
62Adherens junction_Homo sapiens_hsa045200.84167682
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.84019184
64ErbB signaling pathway_Homo sapiens_hsa040120.83515919
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82068162
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77566725
67Legionellosis_Homo sapiens_hsa051340.77291145
68Non-small cell lung cancer_Homo sapiens_hsa052230.76261067
69Viral myocarditis_Homo sapiens_hsa054160.76170654
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.76126765
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75082982
72Long-term potentiation_Homo sapiens_hsa047200.73896088
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72777979
74Graft-versus-host disease_Homo sapiens_hsa053320.71784824
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.71640238
76Thyroid cancer_Homo sapiens_hsa052160.70129307
77Toxoplasmosis_Homo sapiens_hsa051450.69657339
78Leishmaniasis_Homo sapiens_hsa051400.69137321
79GnRH signaling pathway_Homo sapiens_hsa049120.69099186
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69023065
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67694996
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67562027
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67040331
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66220300
85* FoxO signaling pathway_Homo sapiens_hsa040680.65808819
86Notch signaling pathway_Homo sapiens_hsa043300.65719565
87Acute myeloid leukemia_Homo sapiens_hsa052210.65277039
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64713789
89* Apoptosis_Homo sapiens_hsa042100.64102655
90Osteoclast differentiation_Homo sapiens_hsa043800.63795811
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62706226
92Prolactin signaling pathway_Homo sapiens_hsa049170.62625103
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62401522
94MAPK signaling pathway_Homo sapiens_hsa040100.60526888
95Pathways in cancer_Homo sapiens_hsa052000.58969295
96Cholinergic synapse_Homo sapiens_hsa047250.58958179
97Oocyte meiosis_Homo sapiens_hsa041140.58925782
98Ribosome_Homo sapiens_hsa030100.58871969
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58240315
100TNF signaling pathway_Homo sapiens_hsa046680.57393527
101Endometrial cancer_Homo sapiens_hsa052130.57014048
102TGF-beta signaling pathway_Homo sapiens_hsa043500.55197449
103ABC transporters_Homo sapiens_hsa020100.53938661
104Proteoglycans in cancer_Homo sapiens_hsa052050.53632110
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.52678809
106Estrogen signaling pathway_Homo sapiens_hsa049150.52505350
107Platelet activation_Homo sapiens_hsa046110.52496757
108Ras signaling pathway_Homo sapiens_hsa040140.51979086
109Inositol phosphate metabolism_Homo sapiens_hsa005620.51105756
110Purine metabolism_Homo sapiens_hsa002300.49530997
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48944742
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48452372
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47540265
114Basal cell carcinoma_Homo sapiens_hsa052170.47535570
115Type II diabetes mellitus_Homo sapiens_hsa049300.46415855
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46406687
117Type I diabetes mellitus_Homo sapiens_hsa049400.45573505
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.45523371
119African trypanosomiasis_Homo sapiens_hsa051430.45353833
120Hepatitis C_Homo sapiens_hsa051600.45174840
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45055826
122Insulin resistance_Homo sapiens_hsa049310.44037432
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43372429
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.42670270
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42321837
126Phagosome_Homo sapiens_hsa041450.42311410
127HIF-1 signaling pathway_Homo sapiens_hsa040660.41845021
128Chemokine signaling pathway_Homo sapiens_hsa040620.41610684
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.41592652
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.40672035
131Rap1 signaling pathway_Homo sapiens_hsa040150.40555297
132Allograft rejection_Homo sapiens_hsa053300.40409044
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39682622
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36849243
135N-Glycan biosynthesis_Homo sapiens_hsa005100.36776167

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