ATL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.84331263
2nuclear pore organization (GO:0006999)6.27758769
3triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.20798358
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.08087633
5L-phenylalanine catabolic process (GO:0006559)6.08087633
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.84117256
7L-phenylalanine metabolic process (GO:0006558)5.84117256
8aromatic amino acid family catabolic process (GO:0009074)5.64277908
9urea metabolic process (GO:0019627)5.38033852
10urea cycle (GO:0000050)5.38033852
11alpha-linolenic acid metabolic process (GO:0036109)5.37943764
12indole-containing compound catabolic process (GO:0042436)5.26940258
13indolalkylamine catabolic process (GO:0046218)5.26940258
14tryptophan catabolic process (GO:0006569)5.26940258
15kynurenine metabolic process (GO:0070189)5.21293045
16high-density lipoprotein particle remodeling (GO:0034375)5.15438635
17cysteine metabolic process (GO:0006534)5.09175122
18lysine metabolic process (GO:0006553)5.06554952
19lysine catabolic process (GO:0006554)5.06554952
20tryptophan metabolic process (GO:0006568)5.02489658
21bile acid biosynthetic process (GO:0006699)4.95342455
22nitrogen cycle metabolic process (GO:0071941)4.89634269
23regulation of triglyceride catabolic process (GO:0010896)4.88927808
24mitotic chromosome condensation (GO:0007076)4.86952721
25pore complex assembly (GO:0046931)4.83976956
26serine family amino acid catabolic process (GO:0009071)4.81440189
27sulfur amino acid catabolic process (GO:0000098)4.79693102
28amino-acid betaine metabolic process (GO:0006577)4.71969979
29regulation of protein activation cascade (GO:2000257)4.69610304
30reverse cholesterol transport (GO:0043691)4.68571899
31glyoxylate metabolic process (GO:0046487)4.67928828
32homocysteine metabolic process (GO:0050667)4.66816791
33complement activation, alternative pathway (GO:0006957)4.65587411
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.64259104
35negative regulation of fibrinolysis (GO:0051918)4.58613891
36regulation of cholesterol esterification (GO:0010872)4.54473480
37mitotic sister chromatid cohesion (GO:0007064)4.53891567
38macromolecular complex remodeling (GO:0034367)4.53521419
39plasma lipoprotein particle remodeling (GO:0034369)4.53521419
40protein-lipid complex remodeling (GO:0034368)4.53521419
41protein carboxylation (GO:0018214)4.51522903
42peptidyl-glutamic acid carboxylation (GO:0017187)4.51522903
43phospholipid efflux (GO:0033700)4.48840566
44regulation of centriole replication (GO:0046599)4.48379254
45acylglycerol homeostasis (GO:0055090)4.45842068
46triglyceride homeostasis (GO:0070328)4.45842068
47regulation of complement activation (GO:0030449)4.39143830
48protein localization to kinetochore (GO:0034501)4.38021563
49regulation of fibrinolysis (GO:0051917)4.37144694
50dicarboxylic acid biosynthetic process (GO:0043650)4.36546127
51bile acid metabolic process (GO:0008206)4.33069629
52drug catabolic process (GO:0042737)4.26872324
53negative regulation of cholesterol transport (GO:0032375)4.25821877
54negative regulation of sterol transport (GO:0032372)4.25821877
55protein localization to chromosome, centromeric region (GO:0071459)4.23777218
56alpha-amino acid catabolic process (GO:1901606)4.20354172
57sister chromatid segregation (GO:0000819)4.15311838
58DNA unwinding involved in DNA replication (GO:0006268)4.14035691
59mitotic sister chromatid segregation (GO:0000070)4.13603168
60glutamate metabolic process (GO:0006536)4.12478454
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.11396202
62plasma lipoprotein particle assembly (GO:0034377)4.08998711
63regulation of cholesterol homeostasis (GO:2000188)4.07922813
64mitotic metaphase plate congression (GO:0007080)4.04303813
65aromatic amino acid family metabolic process (GO:0009072)4.03631444
66very-low-density lipoprotein particle assembly (GO:0034379)4.00472747
67cellular ketone body metabolic process (GO:0046950)3.98835080
68positive regulation of fatty acid beta-oxidation (GO:0032000)3.98621426
69tyrosine metabolic process (GO:0006570)3.91447596
70cholesterol efflux (GO:0033344)3.90123860
71cellular glucuronidation (GO:0052695)3.89375902
72positive regulation of lipid catabolic process (GO:0050996)3.89206060
73cellular amino acid catabolic process (GO:0009063)3.88657568
74bile acid and bile salt transport (GO:0015721)3.87111471
75glycine metabolic process (GO:0006544)3.83786344
76plasma lipoprotein particle clearance (GO:0034381)3.82590813
77regulation of bile acid biosynthetic process (GO:0070857)3.79108484
78carnitine metabolic process (GO:0009437)3.78441298
792-oxoglutarate metabolic process (GO:0006103)3.77654087
80cellular modified amino acid catabolic process (GO:0042219)3.76498472
81intestinal cholesterol absorption (GO:0030299)3.75984356
82ethanol oxidation (GO:0006069)3.74977682
83protein-lipid complex assembly (GO:0065005)3.74348710
84phospholipid homeostasis (GO:0055091)3.72570738
85regulation of centrosome cycle (GO:0046605)3.72472511
86regulation of sister chromatid cohesion (GO:0007063)3.71536066
87flavonoid metabolic process (GO:0009812)3.71213737
88serine family amino acid metabolic process (GO:0009069)3.68446757
89indolalkylamine metabolic process (GO:0006586)3.65539482
90aspartate family amino acid catabolic process (GO:0009068)3.62735735
91metaphase plate congression (GO:0051310)3.62207221
92short-chain fatty acid metabolic process (GO:0046459)3.61996432
93coenzyme catabolic process (GO:0009109)3.61615230
94negative regulation of lipase activity (GO:0060192)3.58731826
95low-density lipoprotein particle remodeling (GO:0034374)3.58179465
96plasma lipoprotein particle organization (GO:0071827)3.58153011
97benzene-containing compound metabolic process (GO:0042537)3.56630152
98imidazole-containing compound metabolic process (GO:0052803)3.55391516
99exogenous drug catabolic process (GO:0042738)3.54831630
100regulation of centrosome duplication (GO:0010824)3.53020677
101ribosome assembly (GO:0042255)3.51942043
102cellular biogenic amine catabolic process (GO:0042402)3.50682766
103amine catabolic process (GO:0009310)3.50682766
104fatty acid transmembrane transport (GO:1902001)3.48506375
105lipoprotein metabolic process (GO:0042157)3.47529716
106mitotic nuclear envelope disassembly (GO:0007077)3.47457482
107CENP-A containing nucleosome assembly (GO:0034080)3.46362202
108fatty acid oxidation (GO:0019395)3.44048708
109positive regulation of chromosome segregation (GO:0051984)3.44014243
110cholesterol homeostasis (GO:0042632)3.43650659
111epoxygenase P450 pathway (GO:0019373)3.42520805
112positive regulation of lipoprotein lipase activity (GO:0051006)3.41473840
113positive regulation of triglyceride lipase activity (GO:0061365)3.41473840
114protein-lipid complex subunit organization (GO:0071825)3.41314023
115bundle of His cell to Purkinje myocyte communication (GO:0086069)3.41312923
116carboxylic acid catabolic process (GO:0046395)3.41237963
117organic acid catabolic process (GO:0016054)3.41237963
118negative regulation of fatty acid biosynthetic process (GO:0045717)3.41112208
119sterol homeostasis (GO:0055092)3.41092259
120lipid oxidation (GO:0034440)3.40897800
121fatty acid beta-oxidation (GO:0006635)3.38688545
122chromatin remodeling at centromere (GO:0031055)3.38687353
123positive regulation of fatty acid oxidation (GO:0046321)3.38619128
124positive regulation of mitotic sister chromatid separation (GO:1901970)3.35942101
125positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.35942101
126positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.35942101
127nuclear envelope disassembly (GO:0051081)3.32330335
128membrane disassembly (GO:0030397)3.32330335
129regulation of chromosome segregation (GO:0051983)3.31061108
130kinetochore organization (GO:0051383)3.29336654
131spindle checkpoint (GO:0031577)3.21472094
132non-recombinational repair (GO:0000726)3.18579037
133double-strand break repair via nonhomologous end joining (GO:0006303)3.18579037
134establishment of integrated proviral latency (GO:0075713)3.17446652
135mitotic spindle checkpoint (GO:0071174)3.15326409
136regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.12739312
137regulation of mitotic metaphase/anaphase transition (GO:0030071)3.12739312
138negative regulation of chromosome segregation (GO:0051985)3.10483880
139DNA strand elongation involved in DNA replication (GO:0006271)3.08241457
140protein heterotetramerization (GO:0051290)3.07415630
141DNA duplex unwinding (GO:0032508)3.06867638
142regulation of RNA export from nucleus (GO:0046831)3.06518648
143regulation of sister chromatid segregation (GO:0033045)3.05843536
144regulation of mitotic sister chromatid separation (GO:0010965)3.05843536
145regulation of mitotic sister chromatid segregation (GO:0033047)3.05843536
146negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03002620
147negative regulation of mitotic sister chromatid separation (GO:2000816)3.03002620
148negative regulation of sister chromatid segregation (GO:0033046)3.03002620
149negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.03002620
150negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.03002620
151establishment of chromosome localization (GO:0051303)3.01828229
152DNA geometric change (GO:0032392)2.99439807
153chromosome condensation (GO:0030261)2.99263022
154cellular protein complex localization (GO:0034629)2.98898173
155histone exchange (GO:0043486)2.97236648
156protein complex localization (GO:0031503)2.96967428
157DNA strand elongation (GO:0022616)2.94671337
158DNA replication initiation (GO:0006270)2.92292994
159mitotic spindle assembly checkpoint (GO:0007094)2.90531737
160regulation of mitotic spindle organization (GO:0060236)2.89354405
161DNA ligation (GO:0006266)2.89261535
162regulation of spindle organization (GO:0090224)2.89162626
163DNA topological change (GO:0006265)2.87820607
164spindle assembly checkpoint (GO:0071173)2.85215947
165regulation of translational fidelity (GO:0006450)2.82148415
166meiotic chromosome segregation (GO:0045132)2.81915697
167protein localization to chromosome (GO:0034502)2.80844024
168nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.79935987
169regulation of helicase activity (GO:0051095)2.79088862
170pre-miRNA processing (GO:0031054)2.76717043
171DNA replication-independent nucleosome assembly (GO:0006336)2.75338228
172DNA replication-independent nucleosome organization (GO:0034724)2.75338228
173DNA conformation change (GO:0071103)2.73935476
174DNA replication checkpoint (GO:0000076)2.73557116
175attachment of spindle microtubules to kinetochore (GO:0008608)2.73385118
176chromosome segregation (GO:0007059)2.71733623
177paraxial mesoderm development (GO:0048339)2.69810203
178desmosome organization (GO:0002934)2.69336703
179regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.68693104
180regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.67109733
181nuclear envelope organization (GO:0006998)2.66863962
182negative regulation of DNA repair (GO:0045738)2.66462013
183DNA packaging (GO:0006323)2.66159966
184genitalia morphogenesis (GO:0035112)2.65948461
185telomere maintenance via semi-conservative replication (GO:0032201)2.63101133
186IMP metabolic process (GO:0046040)2.63032650
187regulation of DNA endoreduplication (GO:0032875)2.59512310
188DNA replication-dependent nucleosome organization (GO:0034723)2.58027033
189DNA replication-dependent nucleosome assembly (GO:0006335)2.58027033
190mitotic G2/M transition checkpoint (GO:0044818)2.57404239
191positive regulation of cell cycle checkpoint (GO:1901978)2.57189163
192IMP biosynthetic process (GO:0006188)2.56427160
193mitotic recombination (GO:0006312)2.55766993
194synapsis (GO:0007129)2.53169147
195notochord development (GO:0030903)2.52543594
196ATP-dependent chromatin remodeling (GO:0043044)2.51096498
197negative regulation of DNA recombination (GO:0045910)2.47241694
198keratinocyte proliferation (GO:0043616)2.46369700
199negative regulation of mitosis (GO:0045839)2.45443346
200regulation of histone H3-K9 methylation (GO:0051570)2.45176406

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.35566007
2RXR_22158963_ChIP-Seq_LIVER_Mouse7.28856765
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.28343244
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.89595236
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.68093006
6FOXM1_23109430_ChIP-Seq_U2OS_Human5.02067963
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.72585108
8* FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.31175317
9E2F4_17652178_ChIP-ChIP_JURKAT_Human4.22406959
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.14601092
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.69973813
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.31276348
13* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.19600146
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.89155522
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.65131850
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.48749749
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.46855360
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.28631662
19CLOCK_20551151_ChIP-Seq_293T_Human2.20816308
20PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.14029504
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13489144
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02446051
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.1633353
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.97795536
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.96570874
26PADI4_21655091_ChIP-ChIP_MCF-7_Human1.89346267
27* FOXA2_19822575_ChIP-Seq_HepG2_Human1.88592533
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85537445
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80882701
30HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.80661893
31ELK1_19687146_ChIP-ChIP_HELA_Human1.78747366
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77775951
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77742065
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69836012
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.68624276
36* FUS_26573619_Chip-Seq_HEK293_Human1.66284527
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.63690069
38ESR1_15608294_ChIP-ChIP_MCF-7_Human1.57449966
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55076276
40GATA1_22025678_ChIP-Seq_K562_Human1.53045969
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49948311
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48302292
43* HNF4A_19822575_ChIP-Seq_HepG2_Human1.47494114
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46754910
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42917497
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42381648
47TP63_17297297_ChIP-ChIP_HaCaT_Human1.40804844
48TAF15_26573619_Chip-Seq_HEK293_Human1.40509853
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39975190
50* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.36434022
51DCP1A_22483619_ChIP-Seq_HELA_Human1.34142340
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30915591
53EWS_26573619_Chip-Seq_HEK293_Human1.30161441
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.28816722
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.28256418
56HTT_18923047_ChIP-ChIP_STHdh_Human1.26450944
57AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.25209671
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22854830
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.22148041
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21614883
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.19475478
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.18424700
63CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16796153
64HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16411575
65SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15945840
66ZNF263_19887448_ChIP-Seq_K562_Human1.15704875
67BCAT_22108803_ChIP-Seq_LS180_Human1.15232778
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.14984818
69SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13363540
70GABP_17652178_ChIP-ChIP_JURKAT_Human1.13243573
71KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.12569569
72KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.12569569
73KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.12569569
74SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11774275
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10844967
76SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10371493
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10295580
78RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10011483
79* GATA4_25053715_ChIP-Seq_YYC3_Human1.09623284
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08938782
81NANOG_16153702_ChIP-ChIP_HESCs_Human1.08374141
82EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.06868031
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05377210
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03524699
85SOX17_20123909_ChIP-Seq_XEN_Mouse1.03172123
86TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02898393
87ESR1_20079471_ChIP-ChIP_T-47D_Human1.02412172
88ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01489737
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00766895
90ESR2_21235772_ChIP-Seq_MCF-7_Human0.99545881
91THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99367251
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99349898
93* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98992562
94CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98633973
95GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.97210468
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96715306
97NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96192439
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95380445
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95123283
100TTF2_22483619_ChIP-Seq_HELA_Human0.94490859
101FOXO3_23340844_ChIP-Seq_DLD1_Human0.94401170
102EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90745129
103RXR_22108803_ChIP-Seq_LS180_Human0.90034299
104FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89869917
105FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.89324715
106CHD1_26751641_Chip-Seq_LNCaP_Human0.89278846
107* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.89239652
108VDR_22108803_ChIP-Seq_LS180_Human0.89211871
109STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88423953
110STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87641798
111* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87530731
112PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86969568
113HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86441748
114AR_21909140_ChIP-Seq_LNCAP_Human0.86135334
115FLI1_27457419_Chip-Seq_LIVER_Mouse0.86097291
116TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.85326447
117MYC_18940864_ChIP-ChIP_HL60_Human0.85290629
118HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84788122
119* PIAS1_25552417_ChIP-Seq_VCAP_Human0.84633102
120CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84077405
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83989256
122FOXM1_26456572_ChIP-Seq_MCF-7_Human0.83359241
123KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83206002
124POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83064724
125* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82026840
126* FOXP3_21729870_ChIP-Seq_TREG_Human0.81599114
127* VDR_23849224_ChIP-Seq_CD4+_Human0.80558253
128WT1_19549856_ChIP-ChIP_CCG9911_Human0.80027492
129POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.79911307
130GATA6_25053715_ChIP-Seq_YYC3_Human0.79845135
131RXRA_24833708_ChIP-Seq_LIVER_Mouse0.79448192
132ETS1_20019798_ChIP-Seq_JURKAT_Human0.78566532
133RBPJ_22232070_ChIP-Seq_NCS_Mouse0.77288239
134CDX2_22108803_ChIP-Seq_LS180_Human0.76996744
135SOX2_16153702_ChIP-ChIP_HESCs_Human0.74902442
136POU5F1_16153702_ChIP-ChIP_HESCs_Human0.74387874
137NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.74179920
138ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73959321
139FOXA1_25552417_ChIP-Seq_VCAP_Human0.73646044
140SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.70553155
141* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.70000159
142* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70000159
143FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.68474326
144GATA1_19941826_ChIP-Seq_K562_Human0.67335891
145TCF4_18268006_ChIP-ChIP_LS174T_Human0.66235516
146NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.65919153
147TBX20_22328084_ChIP-Seq_HEART_Mouse0.65310929
148TBX20_22080862_ChIP-Seq_HEART_Mouse0.65310929
149CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.64676243
150ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.63916141
151CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.63796602
152NANOG_16518401_ChIP-PET_MESCs_Mouse0.62559517
153GATA2_19941826_ChIP-Seq_K562_Human0.62514384
154ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.62405176
155CBP_21632823_ChIP-Seq_H3396_Human0.62403556
156KAP1_22055183_ChIP-Seq_ESCs_Mouse0.60184670
157PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.58784187
158GATA3_24758297_ChIP-Seq_MCF-7_Human0.58722657
159RARA_24833708_ChIP-Seq_LIVER_Mouse0.57984777
160CEBPB_22108803_ChIP-Seq_LS180_Human0.57513466
161* TP63_23658742_ChIP-Seq_EP156T_Human0.57106605
162TP53_16413492_ChIP-PET_HCT116_Human0.56933700
163RARG_19884340_ChIP-ChIP_MEFs_Mouse0.56128825
164PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.53965488
165* SMAD4_21741376_ChIP-Seq_EPCs_Human0.53747259
166TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.53589096
167ISL1_27105846_Chip-Seq_CPCs_Mouse0.53435015
168* SMAD4_21741376_ChIP-Seq_HESCs_Human0.53092301
169TBX3_20139965_ChIP-Seq_ESCs_Mouse0.52819514
170* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.51454068
171TBX3_20139965_ChIP-Seq_MESCs_Mouse0.51131081
172* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.50827050
173CDX2_20551321_ChIP-Seq_CACO-2_Human0.49950175
174CTNNB1_20460455_ChIP-Seq_HCT116_Human0.49891955
175SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.49789045
176STAT3_1855785_ChIP-Seq_MESCs_Mouse0.49700493
177TCF4_22108803_ChIP-Seq_LS180_Human0.49582015
178Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.49215350
179CDX2_19796622_ChIP-Seq_MESCs_Mouse0.48681353
180* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.48614694
181SOX2_21211035_ChIP-Seq_LN229_Gbm0.48516102

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.87600727
2MP0005360_urolithiasis7.22186696
3MP0005085_abnormal_gallbladder_physiolo5.90414696
4MP0005365_abnormal_bile_salt5.82040227
5MP0008875_abnormal_xenobiotic_pharmacok4.59530539
6MP0008057_abnormal_DNA_replication4.49529621
7MP0003252_abnormal_bile_duct3.87464611
8MP0003806_abnormal_nucleotide_metabolis3.85162375
9MP0010329_abnormal_lipoprotein_level3.58546133
10MP0010094_abnormal_chromosome_stability3.41880105
11MP0003693_abnormal_embryo_hatching3.06495711
12MP0004957_abnormal_blastocyst_morpholog2.97431135
13MP0003941_abnormal_skin_development2.88057725
14MP0003111_abnormal_nucleus_morphology2.83288505
15MP0010352_gastrointestinal_tract_polyps2.79853907
16MP0001666_abnormal_nutrient_absorption2.77043382
17MP0003890_abnormal_embryonic-extraembry2.66508372
18MP0009840_abnormal_foam_cell2.63959033
19MP0003077_abnormal_cell_cycle2.51908342
20MP0005083_abnormal_biliary_tract2.51751061
21MP0005332_abnormal_amino_acid2.49797706
22MP0003195_calcinosis2.24769340
23MP0010678_abnormal_skin_adnexa2.19264194
24MP0002118_abnormal_lipid_homeostasis2.06451585
25MP0000609_abnormal_liver_physiology2.06209804
26MP0008932_abnormal_embryonic_tissue2.05310277
27MP0008058_abnormal_DNA_repair2.05282522
28MP0002138_abnormal_hepatobiliary_system2.02500353
29MP0003868_abnormal_feces_composition1.92893000
30MP0004130_abnormal_muscle_cell1.90425210
31MP0003705_abnormal_hypodermis_morpholog1.85879853
32MP0001730_embryonic_growth_arrest1.85002983
33MP0000566_synostosis1.83355766
34MP0004019_abnormal_vitamin_homeostasis1.79607295
35MP0000383_abnormal_hair_follicle1.75339547
36MP0002009_preneoplasia1.71635533
37MP0003191_abnormal_cellular_cholesterol1.66094991
38MP0001672_abnormal_embryogenesis/_devel1.63262532
39MP0005380_embryogenesis_phenotype1.63262532
40MP0009697_abnormal_copulation1.55827047
41MP0005319_abnormal_enzyme/_coenzyme1.54706763
42MP0003656_abnormal_erythrocyte_physiolo1.53023877
43MP0005670_abnormal_white_adipose1.52713040
44MP0001764_abnormal_homeostasis1.51704233
45MP0002084_abnormal_developmental_patter1.50737797
46MP0003937_abnormal_limbs/digits/tail_de1.49781970
47MP0003984_embryonic_growth_retardation1.47154956
48MP0010234_abnormal_vibrissa_follicle1.45308225
49MP0000350_abnormal_cell_proliferation1.45077921
50MP0002088_abnormal_embryonic_growth/wei1.43909017
51MP0008007_abnormal_cellular_replicative1.43431339
52MP0010307_abnormal_tumor_latency1.41627852
53MP0000537_abnormal_urethra_morphology1.41004786
54MP0001697_abnormal_embryo_size1.38790567
55MP0002971_abnormal_brown_adipose1.38509021
56MP0002254_reproductive_system_inflammat1.35764205
57MP0005409_darkened_coat_color1.34218158
58MP0008877_abnormal_DNA_methylation1.34174824
59MP0002697_abnormal_eye_size1.32093936
60MP0003567_abnormal_fetal_cardiomyocyte1.31786262
61MP0004197_abnormal_fetal_growth/weight/1.29350940
62MP0005584_abnormal_enzyme/coenzyme_acti1.29078070
63MP0002086_abnormal_extraembryonic_tissu1.24416010
64MP0005076_abnormal_cell_differentiation1.23685423
65MP0003646_muscle_fatigue1.21292797
66MP0002080_prenatal_lethality1.19336513
67MP0000647_abnormal_sebaceous_gland1.18517432
68MP0005501_abnormal_skin_physiology1.16974357
69MP0005666_abnormal_adipose_tissue1.16766164
70MP0002085_abnormal_embryonic_tissue1.16347729
71MP0009703_decreased_birth_body1.14206843
72MP0004145_abnormal_muscle_electrophysio1.13422839
73MP0000762_abnormal_tongue_morphology1.13160418
74MP0004147_increased_porphyrin_level1.10568572
75MP0002837_dystrophic_cardiac_calcinosis1.10168825
76MP0005647_abnormal_sex_gland1.10013167
77MP0002233_abnormal_nose_morphology1.08267201
78MP0001293_anophthalmia1.07305245
79MP0003123_paternal_imprinting1.06924208
80MP0000377_abnormal_hair_follicle1.05711498
81MP0002078_abnormal_glucose_homeostasis1.02344150
82MP0009643_abnormal_urine_homeostasis1.02166226
83MP0003786_premature_aging1.01821551
84MP0002269_muscular_atrophy0.99268986
85MP0006036_abnormal_mitochondrial_physio0.99098382
86MP0005334_abnormal_fat_pad0.98136198
87MP0000598_abnormal_liver_morphology0.97275116
88MP0003119_abnormal_digestive_system0.95749953
89MP0004264_abnormal_extraembryonic_tissu0.94115124
90MP0003950_abnormal_plasma_membrane0.93612379
91MP0005248_abnormal_Harderian_gland0.92609363
92MP0001216_abnormal_epidermal_layer0.91665091
93MP0001286_abnormal_eye_development0.91266405
94MP0003221_abnormal_cardiomyocyte_apopto0.91036822
95MP0000428_abnormal_craniofacial_morphol0.90457036
96MP0005266_abnormal_metabolism0.89121227
97MP0004215_abnormal_myocardial_fiber0.89058530
98MP0003566_abnormal_cell_adhesion0.88573530
99MP0001299_abnormal_eye_distance/0.88315347
100MP0010030_abnormal_orbit_morphology0.86011776
101MP0001984_abnormal_olfaction0.85251582
102MP0004782_abnormal_surfactant_physiolog0.84264062
103MP0001929_abnormal_gametogenesis0.84086386
104MP0002111_abnormal_tail_morphology0.82738535
105MP0003943_abnormal_hepatobiliary_system0.82703622
106MP0000358_abnormal_cell_content/0.82049560
107MP0004742_abnormal_vestibular_system0.81684258
108MP0003121_genomic_imprinting0.81671879
109MP0005187_abnormal_penis_morphology0.81658231
110MP0002796_impaired_skin_barrier0.80147373
111MP0000747_muscle_weakness0.79568212
112MP0004185_abnormal_adipocyte_glucose0.78943319
113MP0005535_abnormal_body_temperature0.78778142
114MP0004084_abnormal_cardiac_muscle0.78439466
115MP0000579_abnormal_nail_morphology0.77372029
116MP0004043_abnormal_pH_regulation0.77116104
117MP0004233_abnormal_muscle_weight0.76871909
118MP0003935_abnormal_craniofacial_develop0.76854457
119MP0005636_abnormal_mineral_homeostasis0.76077951
120MP0003453_abnormal_keratinocyte_physiol0.75994610
121MP0003755_abnormal_palate_morphology0.75303778
122MP0005451_abnormal_body_composition0.74881656
123MP0000604_amyloidosis0.73822476
124MP0000467_abnormal_esophagus_morphology0.73062645
125MP0002092_abnormal_eye_morphology0.71745753
126MP0003300_gastrointestinal_ulcer0.71678636
127MP0003122_maternal_imprinting0.71113178
128MP0002877_abnormal_melanocyte_morpholog0.71108288
129MP0010630_abnormal_cardiac_muscle0.70849343
130MP0005376_homeostasis/metabolism_phenot0.70650591
131MP0003385_abnormal_body_wall0.69344808
132MP0001188_hyperpigmentation0.69174041
133MP0006035_abnormal_mitochondrial_morpho0.67730197
134MP0009780_abnormal_chondrocyte_physiolo0.66726190
135MP0009642_abnormal_blood_homeostasis0.66634919
136MP0002210_abnormal_sex_determination0.66165744
137MP0005384_cellular_phenotype0.65093242
138MP0005220_abnormal_exocrine_pancreas0.65042204
139MP0001915_intracranial_hemorrhage0.64985393
140MP0009763_increased_sensitivity_to0.64672062
141MP0009115_abnormal_fat_cell0.63488046
142MP0005448_abnormal_energy_balance0.63019896
143MP0005408_hypopigmentation0.62741349
144MP0005375_adipose_tissue_phenotype0.62270856
145MP0009384_cardiac_valve_regurgitation0.61386789
146MP0009053_abnormal_anal_canal0.60885661
147MP0005620_abnormal_muscle_contractility0.60699197
148MP0003718_maternal_effect0.60095678
149MP0010368_abnormal_lymphatic_system0.59389462
150MP0003186_abnormal_redox_activity0.59288972
151MP0009672_abnormal_birth_weight0.57602225
152MP0009764_decreased_sensitivity_to0.57121530
153MP0000013_abnormal_adipose_tissue0.56838227
154MP0004087_abnormal_muscle_fiber0.56682329
155MP0000749_muscle_degeneration0.55873418
156MP0003329_amyloid_beta_deposits0.55064291
157MP0000427_abnormal_hair_cycle0.54142136
158MP0008961_abnormal_basal_metabolism0.53678458
159MP0003690_abnormal_glial_cell0.53675081
160MP0000639_abnormal_adrenal_gland0.52221131
161MP0001661_extended_life_span0.50759326
162MP0005395_other_phenotype0.49917417
163MP0003953_abnormal_hormone_level0.49873580
164MP0004036_abnormal_muscle_relaxation0.49216768
165MP0009765_abnormal_xenobiotic_induced0.47807703
166MP0002970_abnormal_white_adipose0.47138024
167MP0002876_abnormal_thyroid_physiology0.47115667
168MP0005084_abnormal_gallbladder_morpholo0.46883715
169MP0008872_abnormal_physiological_respon0.44831136
170MP0003699_abnormal_female_reproductive0.44822442
171MP0002822_catalepsy0.43776364
172MP0001756_abnormal_urination0.43495258
173MP0001881_abnormal_mammary_gland0.43186755
174MP0002928_abnormal_bile_duct0.42013273
175MP0003011_delayed_dark_adaptation0.41847943
176MP0002098_abnormal_vibrissa_morphology0.40310348
177MP0002060_abnormal_skin_morphology0.37844019
178MP0002332_abnormal_exercise_endurance0.37634914

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.29634873
2Deep venous thrombosis (HP:0002625)6.09961785
3Hypobetalipoproteinemia (HP:0003563)5.95985462
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.62118977
5Xanthomatosis (HP:0000991)5.42578541
6Abnormality of aromatic amino acid family metabolism (HP:0004338)5.41980292
7Hypolipoproteinemia (HP:0010981)4.99168862
8Prolonged partial thromboplastin time (HP:0003645)4.86490378
9Hyperlipoproteinemia (HP:0010980)4.73594502
10Hypoalphalipoproteinemia (HP:0003233)4.69490231
11Epidermoid cyst (HP:0200040)4.67287040
12Hyperglycinuria (HP:0003108)4.52238025
13Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.44796564
14Complement deficiency (HP:0004431)4.40845668
15Hyperglycinemia (HP:0002154)4.33601161
16Hyperammonemia (HP:0001987)4.29404825
17Ketosis (HP:0001946)4.27673259
18Hypoglycemic coma (HP:0001325)4.16531559
19Chromsome breakage (HP:0040012)4.16435496
20Abnormality of glycine metabolism (HP:0010895)4.16022621
21Abnormality of serine family amino acid metabolism (HP:0010894)4.16022621
22Chromosomal breakage induced by crosslinking agents (HP:0003221)3.98775042
23Abnormality of glutamine family amino acid metabolism (HP:0010902)3.90789264
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.86423632
25Ketoacidosis (HP:0001993)3.75558983
26Abnormality of the common coagulation pathway (HP:0010990)3.71657037
27Abnormality of aspartate family amino acid metabolism (HP:0010899)3.67494960
28Abnormality of methionine metabolism (HP:0010901)3.53695858
29Fat malabsorption (HP:0002630)3.48126719
30Joint hemorrhage (HP:0005261)3.38481137
31Hypercholesterolemia (HP:0003124)3.17173073
32Gout (HP:0001997)3.15378784
33Pancreatic islet-cell hyperplasia (HP:0004510)3.13738719
34Myoglobinuria (HP:0002913)3.07955228
35Exercise-induced myalgia (HP:0003738)3.06155476
36Nephroblastoma (Wilms tumor) (HP:0002667)3.05739579
37Abnormality of the intrinsic pathway (HP:0010989)3.05368023
38Hyperbilirubinemia (HP:0002904)3.04207746
39Abnormality of purine metabolism (HP:0004352)3.04190433
40Dysmetric saccades (HP:0000641)3.02908539
41Abnormality of complement system (HP:0005339)3.00317070
42Abnormality of nucleobase metabolism (HP:0010932)2.98944753
43Hyperglycemia (HP:0003074)2.96502238
44Conjugated hyperbilirubinemia (HP:0002908)2.92630236
45Embryonal renal neoplasm (HP:0011794)2.91835776
46Hypoglycemic seizures (HP:0002173)2.89882729
47Abnormality of chromosome stability (HP:0003220)2.89503085
48Abnormality of pyrimidine metabolism (HP:0004353)2.88453392
49Hepatocellular carcinoma (HP:0001402)2.84320595
50Papillary thyroid carcinoma (HP:0002895)2.82563746
51Hypochromic microcytic anemia (HP:0004840)2.82561286
52Abnormality of fatty-acid metabolism (HP:0004359)2.79381418
53Acanthocytosis (HP:0001927)2.78875207
54Abnormality of serum amino acid levels (HP:0003112)2.76961453
55Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.74257211
56Metabolic acidosis (HP:0001942)2.70721544
57Selective tooth agenesis (HP:0001592)2.68543154
58Exercise-induced muscle cramps (HP:0003710)2.67838877
59Hyperinsulinemic hypoglycemia (HP:0000825)2.63526589
60Hypoplastic labia majora (HP:0000059)2.62928544
61Cholelithiasis (HP:0001081)2.61361772
62Abnormality of the preputium (HP:0100587)2.60338108
63Abnormal gallbladder morphology (HP:0012437)2.55854192
64Delayed CNS myelination (HP:0002188)2.54377417
65Muscle fiber inclusion bodies (HP:0100299)2.53945731
66Scanning speech (HP:0002168)2.52057769
67Myocardial infarction (HP:0001658)2.51699300
68Volvulus (HP:0002580)2.51204132
69Poikilocytosis (HP:0004447)2.48925447
70Abnormality of the salivary glands (HP:0010286)2.48569419
71Skin nodule (HP:0200036)2.48016682
72Increased nuchal translucency (HP:0010880)2.47768534
73Meckel diverticulum (HP:0002245)2.46893264
74Malnutrition (HP:0004395)2.46686935
75Increased purine levels (HP:0004368)2.46529285
76Hyperuricemia (HP:0002149)2.46529285
77Horizontal nystagmus (HP:0000666)2.44716686
78Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.41980903
79Abnormality of the labia majora (HP:0012881)2.40942771
80Abnormality of the ileum (HP:0001549)2.39782087
81Spontaneous abortion (HP:0005268)2.39663365
82Abnormal lung lobation (HP:0002101)2.37980077
83Dicarboxylic aciduria (HP:0003215)2.35781046
84Abnormality of dicarboxylic acid metabolism (HP:0010995)2.35781046
85Rhabdomyolysis (HP:0003201)2.34368259
86Late onset (HP:0003584)2.32971734
87Cholecystitis (HP:0001082)2.30319557
88Abnormal gallbladder physiology (HP:0012438)2.30319557
89Steatorrhea (HP:0002570)2.28263532
90Ankyloglossia (HP:0010296)2.26806542
91Nemaline bodies (HP:0003798)2.24490647
92Absent radius (HP:0003974)2.23073249
93Rhabdomyosarcoma (HP:0002859)2.22926631
94Absent eyebrow (HP:0002223)2.20372282
95Aplasia/Hypoplasia of the uvula (HP:0010293)2.20175279
96Duodenal stenosis (HP:0100867)2.20030136
97Small intestinal stenosis (HP:0012848)2.20030136
98Abnormality of proline metabolism (HP:0010907)2.18237001
99Hydroxyprolinuria (HP:0003080)2.18237001
100Spastic diplegia (HP:0001264)2.17955933
101Increased serum pyruvate (HP:0003542)2.16803961
102Absent eyelashes (HP:0000561)2.14186899
103Lethargy (HP:0001254)2.13606716
104Pili torti (HP:0003777)2.12937992
105Confusion (HP:0001289)2.12833224
106Reticulocytosis (HP:0001923)2.12702869
107Overlapping toe (HP:0001845)2.12496636
108Neonatal onset (HP:0003623)2.12482426
109Abnormality of nail color (HP:0100643)2.12013822
110Status epilepticus (HP:0002133)2.11360014
111Abnormality of glycolysis (HP:0004366)2.10802416
112Back pain (HP:0003418)2.09789617
113Type 1 muscle fiber predominance (HP:0003803)2.08988032
114Sensorimotor neuropathy (HP:0007141)2.08685533
115Medulloblastoma (HP:0002885)2.07084786
116Vascular calcification (HP:0004934)2.06500637
117Malignant gastrointestinal tract tumors (HP:0006749)2.06268443
118Gastrointestinal carcinoma (HP:0002672)2.06268443
119Retinal atrophy (HP:0001105)2.06041805
120Biliary tract neoplasm (HP:0100574)2.05778560
121Symptomatic seizures (HP:0011145)2.04715836
122Onycholysis (HP:0001806)2.04003840
123Absent forearm bone (HP:0003953)2.03318566
124Aplasia involving forearm bones (HP:0009822)2.03318566
125Cortical dysplasia (HP:0002539)2.02237721
126Termporal pattern (HP:0011008)2.01188043
127Insidious onset (HP:0003587)2.01188043
128Duplicated collecting system (HP:0000081)2.00560134
129Renal cortical cysts (HP:0000803)1.98274237
130Hepatoblastoma (HP:0002884)1.98243822
131Thyroid carcinoma (HP:0002890)1.96505139
132Esophageal varix (HP:0002040)1.96194244
133Progressive external ophthalmoplegia (HP:0000590)1.95376873
134Tetraplegia (HP:0002445)1.93238421
135Abnormality of the duodenum (HP:0002246)1.92494078
136Labial hypoplasia (HP:0000066)1.92087020
137Clitoromegaly (HP:0000057)1.91877829
138Thick nail (HP:0001805)1.91285300
139Abnormality of the gallbladder (HP:0005264)1.90577816
140Irritability (HP:0000737)1.89738393
141Hypoplastic female external genitalia (HP:0012815)1.88446832
142Muscle stiffness (HP:0003552)1.85233451
143Uterine neoplasm (HP:0010784)1.84943930
144Ependymoma (HP:0002888)1.84780362
145Deviation of the thumb (HP:0009603)1.84198746
146Pancreatitis (HP:0001733)1.83252104
147Abnormality of vitamin metabolism (HP:0100508)1.83096337
148Uterine leiomyosarcoma (HP:0002891)1.83028483
149Leiomyosarcoma (HP:0100243)1.83028483
150Breast carcinoma (HP:0003002)1.82381275
151Embryonal neoplasm (HP:0002898)1.82233576
152Cardiovascular calcification (HP:0011915)1.81793082
153Ovarian neoplasm (HP:0100615)1.79716961
154Global brain atrophy (HP:0002283)1.79508007
155Birth length less than 3rd percentile (HP:0003561)1.78256652
156Short chin (HP:0000331)1.77302774
157Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.77268694
158Enlarged kidneys (HP:0000105)1.76794812
159Dysdiadochokinesis (HP:0002075)1.76624964
160Abnormality of the Achilles tendon (HP:0005109)1.76062085
161Neoplasm of the small intestine (HP:0100833)1.74250437
162Choanal atresia (HP:0000453)1.73388223
163Proximal placement of thumb (HP:0009623)1.72942557
164Right ventricular cardiomyopathy (HP:0011663)1.72749962
165Colon cancer (HP:0003003)1.72055172
166Hypertriglyceridemia (HP:0002155)1.71785411
167Acute hepatic failure (HP:0006554)1.71602334
168Cafe-au-lait spot (HP:0000957)1.71227215
169Sandal gap (HP:0001852)1.70777524
170Facial hemangioma (HP:0000329)1.70287687
171Curly hair (HP:0002212)1.70072956
172Sparse eyelashes (HP:0000653)1.69941594
173Transitional cell carcinoma of the bladder (HP:0006740)1.69393408
174Insulin-resistant diabetes mellitus (HP:0000831)1.69048204
175Plantar hyperkeratosis (HP:0007556)1.67882570
176Heterotopia (HP:0002282)1.66957591
177Abnormal biliary tract morphology (HP:0012440)1.65956986
178Abnormality of endocrine pancreas physiology (HP:0012093)1.65669288
179Abnormality of the pancreatic islet cells (HP:0006476)1.65669288
180Microglossia (HP:0000171)1.65631299
181Deep philtrum (HP:0002002)1.65486673
182Neoplasm of the colon (HP:0100273)1.64384792
183Glioma (HP:0009733)1.64383543
184Bifid tongue (HP:0010297)1.64077639
185Abnormality of oral frenula (HP:0000190)1.62457151
186Aplasia/Hypoplasia of the sternum (HP:0006714)1.62339235
187Impaired vibration sensation in the lower limbs (HP:0002166)1.61623571
188Abnormality of the renal collecting system (HP:0004742)1.61548370
189Abnormal hair laboratory examination (HP:0003328)1.61334827
190Palmar hyperkeratosis (HP:0010765)1.61014891
191Lip pit (HP:0100267)1.60439157
192Hyperalaninemia (HP:0003348)1.59827408

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.98256741
2SIK13.19302586
3LATS13.16262926
4BUB13.10836809
5FRK2.92498563
6TSSK62.90368268
7CDC72.66276349
8EIF2AK32.56981429
9MAP2K42.56501105
10SRPK12.55876993
11PBK2.49821518
12TRIB32.48042996
13RIPK12.24791806
14ERBB42.22109688
15TAOK32.19639517
16OBSCN2.18379599
17PDK42.08046986
18PDK32.08046986
19WEE12.07930539
20EIF2AK12.07484435
21BRSK22.06369421
22ERN12.05233331
23PKN22.02876388
24INSRR2.01789891
25BRD41.94383770
26PIK3CG1.91305003
27NEK11.90779549
28FGFR41.90195388
29SCYL21.87243085
30MAP2K31.73902931
31PINK11.72358686
32PTK61.68224720
33TRIM281.66314629
34MKNK21.64492343
35SGK31.63372231
36SGK21.60564756
37MST1R1.57545082
38PLK41.55454983
39EPHA21.54109517
40PDK21.53459476
41PLK31.52094936
42MAP3K71.52008402
43ERBB31.49416905
44MKNK11.48800079
45MST41.45850568
46PRKAA21.43294690
47MAP3K121.41952612
48PLK11.38577428
49MAPK111.36455362
50TTN1.32989886
51CAMK1G1.32384396
52BCR1.31008432
53PHKG11.29560145
54PHKG21.29560145
55NEK21.28330272
56BRAF1.26007430
57ZAK1.20719768
58MAPK121.20576191
59PRKAA11.18379989
60STK38L1.15987835
61STK241.15977951
62CAMK1D1.13589892
63TAF11.12632840
64CHEK21.11810544
65EIF2AK21.11606766
66BMPR1B1.10768056
67AKT31.09703841
68FLT31.06591196
69RPS6KB21.05727131
70MAP3K41.05440496
71ATR1.05339587
72MAP2K61.04457219
73NEK91.03965306
74MAP3K61.01152181
75AURKB0.99145621
76FGFR20.98813662
77MAP3K30.98343724
78CDK60.95486765
79CCNB10.93981187
80MAP3K20.93077155
81CHEK10.92772254
82FGFR30.90146125
83CAMKK20.88073245
84LATS20.87255301
85ATM0.84846602
86PIK3CA0.82893653
87BRSK10.81337134
88KSR20.81280383
89CDK70.80942927
90STK30.79189048
91NEK60.77234779
92FER0.77132874
93TTK0.75245133
94MAP2K10.74793817
95RET0.74436463
96CAMKK10.73687452
97JAK20.72367114
98STK390.70687160
99PAK40.69728685
100SGK4940.67883000
101SGK2230.67883000
102ACVR1B0.67871223
103CSNK1A1L0.67829730
104LMTK20.67429695
105EEF2K0.66906475
106DAPK20.66782061
107MAP3K100.66291978
108MAPK70.66155139
109CDK10.65055868
110MAP3K10.63933770
111FGFR10.63632357
112TGFBR10.62352745
113CSNK1E0.62288671
114TAOK20.62040869
115PTK20.61737793
116CDK30.61432095
117STK380.61284795
118NLK0.59967384
119RPS6KA40.58723322
120PDGFRA0.57730205
121RAF10.57170078
122MAP3K50.56042670
123CAMK2G0.55110882
124CDK120.54969310
125PRKACG0.54892957
126MTOR0.54632066
127CDK20.53114649
128MAPKAPK30.52819153
129CDK40.51847595
130CDK90.51647325
131ERBB20.51181013
132GRK60.50974590
133CLK10.48959073
134KSR10.48542252
135NUAK10.47275119
136ICK0.47138405
137MAP3K80.46794991
138MUSK0.44387654
139SGK10.43837757
140CDK80.43434606
141AURKA0.42976750
142RPS6KA30.42909458
143CSNK1G30.42054567
144CSNK1D0.41413753
145VRK10.41189419
146RPS6KB10.40751304
147TAOK10.40285550
148PNCK0.39718093
149ARAF0.39474080
150EPHA40.39346619
151MAP3K90.39172006
152TNIK0.39120419
153SIK30.38804719
154PRKDC0.38101290
155PDK10.37795739
156AKT20.37334494
157MELK0.37064843
158MET0.36726120
159PRKCG0.36085888
160CSNK1G10.36074134
161CAMK40.35941372
162MAPK40.35903637
163CSNK1G20.35748671

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.99503093
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.91610583
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.14510347
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.05804984
5Arginine biosynthesis_Homo sapiens_hsa002203.00728119
6Non-homologous end-joining_Homo sapiens_hsa034502.79349754
7Mismatch repair_Homo sapiens_hsa034302.77952462
8Fatty acid degradation_Homo sapiens_hsa000712.74061766
9DNA replication_Homo sapiens_hsa030302.69377181
10Cell cycle_Homo sapiens_hsa041102.62090747
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.59689539
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55627373
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.54907778
14Tryptophan metabolism_Homo sapiens_hsa003802.50674292
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40686877
16RNA transport_Homo sapiens_hsa030132.28947614
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.28240488
18Complement and coagulation cascades_Homo sapiens_hsa046102.24524912
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.18998387
20Propanoate metabolism_Homo sapiens_hsa006402.15524432
21PPAR signaling pathway_Homo sapiens_hsa033202.07541134
22Fatty acid metabolism_Homo sapiens_hsa012122.00750466
23Butanoate metabolism_Homo sapiens_hsa006501.99385386
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.93400770
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.89566241
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.88611418
27Caffeine metabolism_Homo sapiens_hsa002321.83676120
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.82042616
29Peroxisome_Homo sapiens_hsa041461.79306705
30Bile secretion_Homo sapiens_hsa049761.76839231
31mRNA surveillance pathway_Homo sapiens_hsa030151.70087832
32Selenocompound metabolism_Homo sapiens_hsa004501.69941358
33Chemical carcinogenesis_Homo sapiens_hsa052041.68717997
34beta-Alanine metabolism_Homo sapiens_hsa004101.68130193
35Nucleotide excision repair_Homo sapiens_hsa034201.67261901
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.64572165
37Fanconi anemia pathway_Homo sapiens_hsa034601.62970814
38Oocyte meiosis_Homo sapiens_hsa041141.62769423
39Sulfur metabolism_Homo sapiens_hsa009201.58191806
40Starch and sucrose metabolism_Homo sapiens_hsa005001.57980593
41Homologous recombination_Homo sapiens_hsa034401.57726368
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.57472953
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55750411
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53992250
45Pyruvate metabolism_Homo sapiens_hsa006201.51861480
46Fat digestion and absorption_Homo sapiens_hsa049751.51132247
47Spliceosome_Homo sapiens_hsa030401.51005346
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.48010907
49Basal transcription factors_Homo sapiens_hsa030221.47906802
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.46817009
51Histidine metabolism_Homo sapiens_hsa003401.41210729
52Retinol metabolism_Homo sapiens_hsa008301.40721768
53Thyroid cancer_Homo sapiens_hsa052161.39842766
54Phenylalanine metabolism_Homo sapiens_hsa003601.38428067
55Biosynthesis of amino acids_Homo sapiens_hsa012301.36982417
56Carbon metabolism_Homo sapiens_hsa012001.35541440
57RNA degradation_Homo sapiens_hsa030181.34354162
58Maturity onset diabetes of the young_Homo sapiens_hsa049501.27490789
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25398061
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.23186546
61Adherens junction_Homo sapiens_hsa045201.21626414
62Base excision repair_Homo sapiens_hsa034101.21130710
63ABC transporters_Homo sapiens_hsa020101.21121095
64Fatty acid biosynthesis_Homo sapiens_hsa000611.20601139
65Tyrosine metabolism_Homo sapiens_hsa003501.18064391
66Staphylococcus aureus infection_Homo sapiens_hsa051501.08796341
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06626401
68Long-term depression_Homo sapiens_hsa047301.05303765
69Lysine degradation_Homo sapiens_hsa003101.05079257
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04177551
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04037953
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01432343
73Vitamin digestion and absorption_Homo sapiens_hsa049771.01210444
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00928027
75Folate biosynthesis_Homo sapiens_hsa007900.99515116
76Glycerolipid metabolism_Homo sapiens_hsa005610.96264327
77p53 signaling pathway_Homo sapiens_hsa041150.93692669
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.92473634
79Vitamin B6 metabolism_Homo sapiens_hsa007500.92134497
80Arginine and proline metabolism_Homo sapiens_hsa003300.85990267
81TGF-beta signaling pathway_Homo sapiens_hsa043500.85430159
82Proteasome_Homo sapiens_hsa030500.84842686
83Hippo signaling pathway_Homo sapiens_hsa043900.81376507
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76672656
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75333782
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74442096
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73655800
88MicroRNAs in cancer_Homo sapiens_hsa052060.67214677
89N-Glycan biosynthesis_Homo sapiens_hsa005100.67057990
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65408955
91Pentose phosphate pathway_Homo sapiens_hsa000300.64931565
92Fatty acid elongation_Homo sapiens_hsa000620.64920712
93Tight junction_Homo sapiens_hsa045300.61861592
94Glucagon signaling pathway_Homo sapiens_hsa049220.61792473
95Insulin resistance_Homo sapiens_hsa049310.61084968
96Systemic lupus erythematosus_Homo sapiens_hsa053220.59704507
97Small cell lung cancer_Homo sapiens_hsa052220.58575027
98Galactose metabolism_Homo sapiens_hsa000520.57959503
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57700652
100Circadian rhythm_Homo sapiens_hsa047100.57077512
101One carbon pool by folate_Homo sapiens_hsa006700.55721253
102Long-term potentiation_Homo sapiens_hsa047200.55405975
103Wnt signaling pathway_Homo sapiens_hsa043100.55016963
104Alcoholism_Homo sapiens_hsa050340.52934916
105Fructose and mannose metabolism_Homo sapiens_hsa000510.50575187
106Glutathione metabolism_Homo sapiens_hsa004800.50257330
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48938174
108RNA polymerase_Homo sapiens_hsa030200.48045108
109Sulfur relay system_Homo sapiens_hsa041220.46693437
110Steroid biosynthesis_Homo sapiens_hsa001000.46392953
111Protein export_Homo sapiens_hsa030600.45944241
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.45138489
113Purine metabolism_Homo sapiens_hsa002300.44119976
114Pyrimidine metabolism_Homo sapiens_hsa002400.41858118
115Inositol phosphate metabolism_Homo sapiens_hsa005620.41531860
116Prostate cancer_Homo sapiens_hsa052150.40236848
117Colorectal cancer_Homo sapiens_hsa052100.37661540
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37325230
119Viral carcinogenesis_Homo sapiens_hsa052030.36755367
120AMPK signaling pathway_Homo sapiens_hsa041520.35902246
121Endometrial cancer_Homo sapiens_hsa052130.34356325
122Proteoglycans in cancer_Homo sapiens_hsa052050.34290253
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.33564308
124ErbB signaling pathway_Homo sapiens_hsa040120.31852356
125Insulin signaling pathway_Homo sapiens_hsa049100.31307726
126Metabolic pathways_Homo sapiens_hsa011000.30362931
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24081529
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20274869
129Type II diabetes mellitus_Homo sapiens_hsa049300.13000377
130Prion diseases_Homo sapiens_hsa050200.12481227
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.12400265
132Thyroid hormone synthesis_Homo sapiens_hsa049180.12250614
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12060148
134Linoleic acid metabolism_Homo sapiens_hsa005910.10241183
135Ovarian steroidogenesis_Homo sapiens_hsa049130.09106471
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.08105025
137FoxO signaling pathway_Homo sapiens_hsa040680.07836013
138Mineral absorption_Homo sapiens_hsa049780.07290767
139Dorso-ventral axis formation_Homo sapiens_hsa043200.05000214
140Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.03396432
141Insulin secretion_Homo sapiens_hsa049110.00052019
142Regulation of autophagy_Homo sapiens_hsa04140-0.1165510
143Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1037009
144Protein digestion and absorption_Homo sapiens_hsa04974-0.0927624
145Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0904633
146Renin-angiotensin system_Homo sapiens_hsa04614-0.0652323
147Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0406102
148Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.0330645
149mTOR signaling pathway_Homo sapiens_hsa04150-0.0294267

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