ATL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.50799999
2neuron cell-cell adhesion (GO:0007158)5.40750464
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.30349918
4vocalization behavior (GO:0071625)5.28998645
5synaptic vesicle exocytosis (GO:0016079)5.21332581
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.15475406
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.91435414
8protein localization to synapse (GO:0035418)4.90730372
9glutamate secretion (GO:0014047)4.78066443
10regulation of synaptic vesicle exocytosis (GO:2000300)4.70110595
11neuronal action potential propagation (GO:0019227)4.66966214
12nucleobase catabolic process (GO:0046113)4.64987491
13regulation of glutamate receptor signaling pathway (GO:1900449)4.60048638
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.48634753
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.47980121
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.47810384
17presynaptic membrane assembly (GO:0097105)4.36662994
18locomotory exploration behavior (GO:0035641)4.33176744
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.28914812
20synaptic vesicle maturation (GO:0016188)4.27128026
21glutamate receptor signaling pathway (GO:0007215)4.24177660
22regulation of synaptic vesicle transport (GO:1902803)4.18761626
23presynaptic membrane organization (GO:0097090)4.14646432
24neuron-neuron synaptic transmission (GO:0007270)4.09069000
25neuron recognition (GO:0008038)4.06831085
26neurotransmitter secretion (GO:0007269)3.99740233
27synaptic transmission, glutamatergic (GO:0035249)3.98215353
28neurotransmitter-gated ion channel clustering (GO:0072578)3.97971640
29gamma-aminobutyric acid signaling pathway (GO:0007214)3.92532063
30postsynaptic membrane organization (GO:0001941)3.90363931
31exploration behavior (GO:0035640)3.88093400
32establishment of mitochondrion localization (GO:0051654)3.84621712
33negative regulation of synaptic transmission, GABAergic (GO:0032229)3.77877609
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.77864915
35regulation of neuronal synaptic plasticity (GO:0048168)3.75417991
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.75088747
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.63753159
38regulation of postsynaptic membrane potential (GO:0060078)3.61767276
39response to histamine (GO:0034776)3.59632444
40axonal fasciculation (GO:0007413)3.53869915
41proline transport (GO:0015824)3.51379471
42long-term synaptic potentiation (GO:0060291)3.51001335
43neurofilament cytoskeleton organization (GO:0060052)3.45990131
44regulation of synapse structural plasticity (GO:0051823)3.44819457
45behavioral response to nicotine (GO:0035095)3.44759538
46regulation of synaptic transmission, glutamatergic (GO:0051966)3.44183679
47negative regulation of dendrite morphogenesis (GO:0050774)3.43732532
48neuronal ion channel clustering (GO:0045161)3.42357780
49neurotransmitter transport (GO:0006836)3.40286461
50positive regulation of membrane potential (GO:0045838)3.38131874
51synaptic vesicle endocytosis (GO:0048488)3.37858292
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.34310242
53transmission of nerve impulse (GO:0019226)3.32815387
54regulation of glutamate secretion (GO:0014048)3.31324726
55regulation of synaptic plasticity (GO:0048167)3.30663597
56behavioral response to cocaine (GO:0048148)3.29320022
57positive regulation of synapse maturation (GO:0090129)3.29180152
58regulation of neurotransmitter secretion (GO:0046928)3.28819070
59positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.28342226
60behavioral fear response (GO:0001662)3.26414448
61behavioral defense response (GO:0002209)3.26414448
62G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.25948265
63layer formation in cerebral cortex (GO:0021819)3.25844418
64regulation of vesicle fusion (GO:0031338)3.25513950
65gamma-aminobutyric acid transport (GO:0015812)3.23423418
66negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.22822176
67glycosphingolipid biosynthetic process (GO:0006688)3.22010152
68positive regulation of synapse assembly (GO:0051965)3.20559073
69positive regulation of dendritic spine morphogenesis (GO:0061003)3.19809017
70positive regulation of neurotransmitter secretion (GO:0001956)3.19343781
71C4-dicarboxylate transport (GO:0015740)3.19199747
72fear response (GO:0042596)3.18636286
73long-term memory (GO:0007616)3.18533039
74positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.18167865
75positive regulation of neurotransmitter transport (GO:0051590)3.16256126
76membrane depolarization (GO:0051899)3.15994365
77regulation of dendritic spine morphogenesis (GO:0061001)3.15527286
78negative regulation of dendrite development (GO:2000171)3.14816368
79neuromuscular synaptic transmission (GO:0007274)3.13938408
80cerebellar Purkinje cell differentiation (GO:0021702)3.13559011
81regulation of neurotransmitter levels (GO:0001505)3.12388259
82dendritic spine morphogenesis (GO:0060997)3.11426123
83synapse assembly (GO:0007416)3.10222477
84positive regulation of synaptic transmission, GABAergic (GO:0032230)3.09610424
85regulation of neurotransmitter transport (GO:0051588)3.05783533
86central nervous system projection neuron axonogenesis (GO:0021952)3.04774335
87adult walking behavior (GO:0007628)3.04601171
88cellular potassium ion homeostasis (GO:0030007)3.02955921
89membrane depolarization during action potential (GO:0086010)3.02816792
90auditory behavior (GO:0031223)2.99861640
91acidic amino acid transport (GO:0015800)2.99781860
92cell migration in hindbrain (GO:0021535)2.99704874
93energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.98982481
94ATP hydrolysis coupled proton transport (GO:0015991)2.98982481
95startle response (GO:0001964)2.98924712
96response to auditory stimulus (GO:0010996)2.98803333
97learning (GO:0007612)2.98351915
98dendrite morphogenesis (GO:0048813)2.98189990
99cerebellar granule cell differentiation (GO:0021707)2.97758008
100regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.97588168
101G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.96965281
102synaptic transmission (GO:0007268)2.96188199
103innervation (GO:0060384)2.95821419
104mechanosensory behavior (GO:0007638)2.94383970
105membrane hyperpolarization (GO:0060081)2.93240464
106positive regulation of synaptic transmission (GO:0050806)2.92979600
107calcium ion-dependent exocytosis (GO:0017156)2.92871108
108positive regulation of dendritic spine development (GO:0060999)2.92690396
109activation of protein kinase A activity (GO:0034199)2.92018885
110regulation of dendritic spine development (GO:0060998)2.91533745
111regulation of synaptic transmission (GO:0050804)2.89798383
112regulation of synaptic transmission, GABAergic (GO:0032228)2.89458918
113regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.88020380
114short-term memory (GO:0007614)2.87031819
115social behavior (GO:0035176)2.85944890
116intraspecies interaction between organisms (GO:0051703)2.85944890
117regulation of voltage-gated calcium channel activity (GO:1901385)2.85178185
118establishment of synaptic vesicle localization (GO:0097480)2.85133487
119synaptic vesicle transport (GO:0048489)2.85133487
120synapse organization (GO:0050808)2.84876997
121detection of calcium ion (GO:0005513)2.84146303
122mitochondrion transport along microtubule (GO:0047497)2.83452024
123establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.83452024
124positive regulation of amino acid transport (GO:0051957)2.83448198
125serotonin metabolic process (GO:0042428)2.76927804

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.06179071
2GBX2_23144817_ChIP-Seq_PC3_Human4.16969492
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10375290
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99842096
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97061145
6TAF15_26573619_Chip-Seq_HEK293_Human2.69443560
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.60447166
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60357092
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54653231
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54653231
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.50614287
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.50602753
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46316550
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44622321
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33220577
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33171344
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.29321115
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.27437327
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.24937790
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.10555983
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.10555827
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07612113
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06297657
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05350329
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.04128336
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.03083440
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85097890
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.84223165
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83654073
30SMAD4_21799915_ChIP-Seq_A2780_Human1.83354065
31AR_21572438_ChIP-Seq_LNCaP_Human1.81250463
32P300_19829295_ChIP-Seq_ESCs_Human1.80915091
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.80387377
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79950804
35DROSHA_22980978_ChIP-Seq_HELA_Human1.78779575
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73354049
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68280522
38VDR_22108803_ChIP-Seq_LS180_Human1.63762362
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62325643
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61585754
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61249740
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.57335115
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55104867
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50990833
45ZNF274_21170338_ChIP-Seq_K562_Hela1.50013962
46FUS_26573619_Chip-Seq_HEK293_Human1.49670903
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.47646575
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44728036
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44307278
50IGF1R_20145208_ChIP-Seq_DFB_Human1.44158005
51RNF2_27304074_Chip-Seq_NSC_Mouse1.44124505
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42603018
53* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41430741
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40336007
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.40238371
56AR_25329375_ChIP-Seq_VCAP_Human1.38723228
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35390486
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33801222
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.31021079
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28447362
61STAT3_23295773_ChIP-Seq_U87_Human1.26410395
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.25560917
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.23742113
64EWS_26573619_Chip-Seq_HEK293_Human1.23283687
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21219974
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17838310
67PRDM14_20953172_ChIP-Seq_ESCs_Human1.15408034
68* TCF4_23295773_ChIP-Seq_U87_Human1.14076726
69ER_23166858_ChIP-Seq_MCF-7_Human1.13246253
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13161150
71CBP_20019798_ChIP-Seq_JUKART_Human1.13161150
72JUN_21703547_ChIP-Seq_K562_Human1.12259273
73RUNX2_22187159_ChIP-Seq_PCA_Human1.11997531
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.11652410
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.11512401
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10434424
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10064100
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.09506106
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09488725
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09302016
81RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07545983
82FLI1_27457419_Chip-Seq_LIVER_Mouse1.07397004
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07228795
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06861349
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05536910
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05067665
87* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04872999
88AR_19668381_ChIP-Seq_PC3_Human1.04706570
89* TAL1_26923725_Chip-Seq_HPCs_Mouse1.04197189
90AHR_22903824_ChIP-Seq_MCF-7_Human1.04031828
91EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03219628
92E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02759330
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01081335
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00701331
95KDM2B_26808549_Chip-Seq_REH_Human0.99141343
96BCAT_22108803_ChIP-Seq_LS180_Human0.98646534
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97251011
98YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96801107
99FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96158930
100P53_22387025_ChIP-Seq_ESCs_Mouse0.95548691
101* FLI1_21867929_ChIP-Seq_TH2_Mouse0.95379830
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95095623
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95095623
104ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94901198
105SOX9_26525672_Chip-Seq_HEART_Mouse0.94861558
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93699414
107TP53_18474530_ChIP-ChIP_U2OS_Human0.93049041
108SMAD3_21741376_ChIP-Seq_ESCs_Human0.92538337
109NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92457730
110E2F1_18555785_Chip-Seq_ESCs_Mouse0.92278365
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92041581
112BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91452692
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90925481
114* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89881759

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.54452437
2MP0004859_abnormal_synaptic_plasticity5.27272319
3MP0003635_abnormal_synaptic_transmissio3.85505832
4MP0004270_analgesia3.72035853
5MP0001968_abnormal_touch/_nociception3.55336728
6MP0009745_abnormal_behavioral_response3.38038444
7MP0002063_abnormal_learning/memory/cond3.18453792
8MP0002064_seizures3.06781117
9MP0002736_abnormal_nociception_after3.04234239
10MP0009046_muscle_twitch2.98665227
11MP0002735_abnormal_chemical_nociception2.88827141
12MP0002572_abnormal_emotion/affect_behav2.82806779
13MP0002734_abnormal_mechanical_nocicepti2.75727473
14MP0002272_abnormal_nervous_system2.64130617
15MP0006276_abnormal_autonomic_nervous2.63676517
16MP0002822_catalepsy2.45396561
17MP0001486_abnormal_startle_reflex2.39728806
18MP0001440_abnormal_grooming_behavior2.39687509
19MP0005423_abnormal_somatic_nervous2.32824656
20MP0001501_abnormal_sleep_pattern2.31806383
21MP0002733_abnormal_thermal_nociception2.28564689
22MP0001529_abnormal_vocalization2.18569953
23MP0001970_abnormal_pain_threshold2.16041143
24MP0002067_abnormal_sensory_capabilities2.13567641
25MP0002184_abnormal_innervation1.94225411
26MP0000778_abnormal_nervous_system1.92309713
27MP0004924_abnormal_behavior1.81763730
28MP0005386_behavior/neurological_phenoty1.81763730
29MP0003329_amyloid_beta_deposits1.76171559
30MP0001905_abnormal_dopamine_level1.71187855
31MP0002557_abnormal_social/conspecific_i1.69900172
32MP0001984_abnormal_olfaction1.69469987
33MP0009780_abnormal_chondrocyte_physiolo1.67669331
34MP0005646_abnormal_pituitary_gland1.65665539
35MP0003879_abnormal_hair_cell1.62078880
36MP0004858_abnormal_nervous_system1.58337281
37MP0003787_abnormal_imprinting1.58234967
38MP0004811_abnormal_neuron_physiology1.56324958
39MP0008569_lethality_at_weaning1.48406416
40MP0002837_dystrophic_cardiac_calcinosis1.47763404
41MP0003122_maternal_imprinting1.47578790
42MP0000955_abnormal_spinal_cord1.47112602
43MP0001188_hyperpigmentation1.46217591
44MP0000569_abnormal_digit_pigmentation1.40238842
45MP0004142_abnormal_muscle_tone1.39230831
46MP0002882_abnormal_neuron_morphology1.37687863
47MP0002066_abnormal_motor_capabilities/c1.37382490
48MP0005645_abnormal_hypothalamus_physiol1.32987188
49MP0002909_abnormal_adrenal_gland1.26237194
50MP0001502_abnormal_circadian_rhythm1.21701146
51MP0010386_abnormal_urinary_bladder1.17187428
52MP0003633_abnormal_nervous_system1.13574866
53MP0006072_abnormal_retinal_apoptosis1.09574232
54MP0004742_abnormal_vestibular_system1.07181320
55MP0000751_myopathy1.06792586
56MP0005253_abnormal_eye_physiology1.03193208
57MP0002152_abnormal_brain_morphology1.02624170
58MP0004145_abnormal_muscle_electrophysio1.02558237
59MP0002876_abnormal_thyroid_physiology1.01834923
60MP0004147_increased_porphyrin_level1.01583816
61MP0003631_nervous_system_phenotype1.00914265
62MP0008872_abnormal_physiological_respon0.99883514
63MP0002229_neurodegeneration0.97165430
64MP0001963_abnormal_hearing_physiology0.95986086
65MP0004885_abnormal_endolymph0.94817317
66MP0008789_abnormal_olfactory_epithelium0.91973509
67MP0002069_abnormal_eating/drinking_beha0.89534585
68MP0002234_abnormal_pharynx_morphology0.88845991
69MP0005551_abnormal_eye_electrophysiolog0.86560697
70MP0002752_abnormal_somatic_nervous0.85166381
71MP0005409_darkened_coat_color0.84346762
72MP0004085_abnormal_heartbeat0.83328172
73MP0000631_abnormal_neuroendocrine_gland0.82467294
74MP0008874_decreased_physiological_sensi0.82304443
75MP0004484_altered_response_of0.79773422
76MP0005535_abnormal_body_temperature0.79556744
77MP0005499_abnormal_olfactory_system0.77100471
78MP0005394_taste/olfaction_phenotype0.77100471
79MP0004133_heterotaxia0.77025141
80MP0000013_abnormal_adipose_tissue0.76319324
81MP0005187_abnormal_penis_morphology0.75911028
82MP0005171_absent_coat_pigmentation0.75791568
83MP0001986_abnormal_taste_sensitivity0.74457558
84MP0000604_amyloidosis0.73631543
85MP0001485_abnormal_pinna_reflex0.72403574
86MP0002638_abnormal_pupillary_reflex0.72296727
87MP0003634_abnormal_glial_cell0.72237517
88MP0001664_abnormal_digestion0.72107536
89MP0003011_delayed_dark_adaptation0.70376392
90MP0005410_abnormal_fertilization0.70020653
91MP0000566_synostosis0.69502537
92MP0004215_abnormal_myocardial_fiber0.68869791
93MP0005084_abnormal_gallbladder_morpholo0.68412353
94MP0003632_abnormal_nervous_system0.67577803
95MP0002751_abnormal_autonomic_nervous0.66060690
96MP0000026_abnormal_inner_ear0.66028459
97MP0003123_paternal_imprinting0.65948653
98MP0000920_abnormal_myelination0.63738512
99MP0005195_abnormal_posterior_eye0.62775139
100MP0003890_abnormal_embryonic-extraembry0.62099061
101MP0001299_abnormal_eye_distance/0.61664121
102MP0001943_abnormal_respiration0.60042891
103MP0006292_abnormal_olfactory_placode0.58659958
104MP0008877_abnormal_DNA_methylation0.57597061
105MP0004043_abnormal_pH_regulation0.57360696
106MP0002090_abnormal_vision0.57238082
107MP0003121_genomic_imprinting0.57133791
108MP0003690_abnormal_glial_cell0.56597779
109MP0001177_atelectasis0.56405521
110MP0003861_abnormal_nervous_system0.52582861
111MP0003137_abnormal_impulse_conducting0.51513123
112MP0003183_abnormal_peptide_metabolism0.50613831
113MP0002102_abnormal_ear_morphology0.49804374
114MP0003646_muscle_fatigue0.49622418
115MP0002653_abnormal_ependyma_morphology0.49061635
116MP0010770_preweaning_lethality0.47772631
117MP0002082_postnatal_lethality0.47772631
118MP0005623_abnormal_meninges_morphology0.47530132
119MP0010769_abnormal_survival0.46264854

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.03299043
2Myokymia (HP:0002411)6.13380318
3Focal seizures (HP:0007359)5.65681230
4Atonic seizures (HP:0010819)5.53036567
5Epileptic encephalopathy (HP:0200134)5.29039270
6Febrile seizures (HP:0002373)4.83697255
7Visual hallucinations (HP:0002367)4.68522401
8Absence seizures (HP:0002121)4.43251822
9Hyperventilation (HP:0002883)4.38279097
10Dialeptic seizures (HP:0011146)4.15789174
11Progressive cerebellar ataxia (HP:0002073)4.11353166
12Generalized tonic-clonic seizures (HP:0002069)3.83514689
13Broad-based gait (HP:0002136)3.63813366
14Amblyopia (HP:0000646)3.54720440
15Action tremor (HP:0002345)3.15720373
16Supranuclear gaze palsy (HP:0000605)3.14402769
17Gaze-evoked nystagmus (HP:0000640)3.09043463
18Truncal ataxia (HP:0002078)3.08275598
19Abnormal eating behavior (HP:0100738)3.04064172
20Poor eye contact (HP:0000817)2.98535730
21Drooling (HP:0002307)2.89512439
22Excessive salivation (HP:0003781)2.89512439
23Polyphagia (HP:0002591)2.86707029
24Ankle clonus (HP:0011448)2.81306950
25Anxiety (HP:0000739)2.79199517
26Dysmetria (HP:0001310)2.79125399
27Dysdiadochokinesis (HP:0002075)2.77901546
28Cerebral inclusion bodies (HP:0100314)2.77302959
29Pheochromocytoma (HP:0002666)2.75977703
30Limb dystonia (HP:0002451)2.72486429
31Progressive inability to walk (HP:0002505)2.70108085
32Epileptiform EEG discharges (HP:0011182)2.69525895
33Lissencephaly (HP:0001339)2.65558864
34Impaired social interactions (HP:0000735)2.65057729
35Abnormal social behavior (HP:0012433)2.65057729
36Depression (HP:0000716)2.63301095
37Intention tremor (HP:0002080)2.62667432
38Gait imbalance (HP:0002141)2.61274484
39Spastic tetraplegia (HP:0002510)2.60683048
40Neurofibrillary tangles (HP:0002185)2.59337856
41Inability to walk (HP:0002540)2.54051782
42Absent speech (HP:0001344)2.52981932
43Neuroendocrine neoplasm (HP:0100634)2.51394745
44Scanning speech (HP:0002168)2.50494551
45EEG with generalized epileptiform discharges (HP:0011198)2.47445079
46Abnormal hair whorl (HP:0010721)2.44419832
47Fetal akinesia sequence (HP:0001989)2.38310734
48Abnormality of the labia minora (HP:0012880)2.36585018
49Mutism (HP:0002300)2.34347691
50Hemiparesis (HP:0001269)2.34231887
51Delusions (HP:0000746)2.32745588
52Medial flaring of the eyebrow (HP:0010747)2.30818838
53Failure to thrive in infancy (HP:0001531)2.30461127
54Protruding tongue (HP:0010808)2.30161185
55Abnormality of binocular vision (HP:0011514)2.30100711
56Diplopia (HP:0000651)2.30100711
57Acute necrotizing encephalopathy (HP:0006965)2.28282374
58Hypsarrhythmia (HP:0002521)2.27719323
59Dynein arm defect of respiratory motile cilia (HP:0012255)2.26682060
60Absent/shortened dynein arms (HP:0200106)2.26682060
61Impaired smooth pursuit (HP:0007772)2.26066522
62Congenital primary aphakia (HP:0007707)2.24818517
63Pachygyria (HP:0001302)2.21948598
64* Urinary urgency (HP:0000012)2.21055717
65* Impaired vibration sensation in the lower limbs (HP:0002166)2.20226251
66Sleep apnea (HP:0010535)2.18772488
67Esotropia (HP:0000565)2.14896911
68Specific learning disability (HP:0001328)2.14888027
69Progressive macrocephaly (HP:0004481)2.13463042
70Hyperthyroidism (HP:0000836)2.13338199
71Bradykinesia (HP:0002067)2.12492917
72Abnormality of midbrain morphology (HP:0002418)2.12276624
73Molar tooth sign on MRI (HP:0002419)2.12276624
74Postural instability (HP:0002172)2.12256103
75Nephrogenic diabetes insipidus (HP:0009806)2.10671950
76Abnormal mitochondria in muscle tissue (HP:0008316)2.08205756
77Abnormality of the lower motor neuron (HP:0002366)2.08108186
78True hermaphroditism (HP:0010459)2.07580037
79Blue irides (HP:0000635)2.06888187
80Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.06833719
81Genetic anticipation (HP:0003743)2.04777679
82Stereotypic behavior (HP:0000733)2.03041949
83Poor suck (HP:0002033)2.02609049
84* Abnormality of the corticospinal tract (HP:0002492)2.01760752
85Generalized myoclonic seizures (HP:0002123)2.01233234
86* Spastic gait (HP:0002064)2.00976647
87Abnormality of salivation (HP:0100755)2.00220449
88Torticollis (HP:0000473)2.00159774
89* Lower limb muscle weakness (HP:0007340)1.98196218
90Pancreatic fibrosis (HP:0100732)1.97417616
91Psychosis (HP:0000709)1.97128871
92Genital tract atresia (HP:0001827)1.96805817
93Ulnar claw (HP:0001178)1.96441590
94Nephronophthisis (HP:0000090)1.95545775
95Retinal dysplasia (HP:0007973)1.94800198
96Focal dystonia (HP:0004373)1.94690613
97Type II lissencephaly (HP:0007260)1.94108216
98Status epilepticus (HP:0002133)1.94106665
99Hypoventilation (HP:0002791)1.93966139
100* Hypoplasia of the corpus callosum (HP:0002079)1.92372716
101* Urinary bladder sphincter dysfunction (HP:0002839)1.91917120
102Abnormality of ocular smooth pursuit (HP:0000617)1.91558842
103Abnormal ciliary motility (HP:0012262)1.90035540
104Optic nerve hypoplasia (HP:0000609)1.90017871
105Hypothermia (HP:0002045)1.89888789
106Gait ataxia (HP:0002066)1.89571676
107Amyotrophic lateral sclerosis (HP:0007354)1.88924417
108Vaginal atresia (HP:0000148)1.88908154
109Papilledema (HP:0001085)1.88889246
110Hypoplasia of the brainstem (HP:0002365)1.88539771
111Aplasia/Hypoplasia of the brainstem (HP:0007362)1.88539771
112Dysmetric saccades (HP:0000641)1.87836608
113Exotropia (HP:0000577)1.87364237
114Clonus (HP:0002169)1.83588501
115Atrophy/Degeneration involving motor neurons (HP:0007373)1.82952543
116Agitation (HP:0000713)1.82415371
117Muscular hypotonia of the trunk (HP:0008936)1.82303556
118Hemiplegia (HP:0002301)1.81915501
119* Morphological abnormality of the pyramidal tract (HP:0002062)1.79843143
120Akinesia (HP:0002304)1.79279959
121Abnormal respiratory motile cilium physiology (HP:0012261)1.77908551
122Cortical dysplasia (HP:0002539)1.77118122
123Thyroid-stimulating hormone excess (HP:0002925)1.76465259
124Split foot (HP:0001839)1.76390803
125Dyskinesia (HP:0100660)1.75980725
126Pancreatic cysts (HP:0001737)1.75898711
127CNS hypomyelination (HP:0003429)1.75688678
128Abnormality of pain sensation (HP:0010832)1.75237033
129Impaired pain sensation (HP:0007328)1.75237033
130Cerebral hypomyelination (HP:0006808)1.73637078

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.36075682
2NTRK34.03195168
3EPHA43.93922775
4MAP3K43.27629445
5MAP3K93.19860776
6MAP2K73.00776764
7MAP3K122.98557336
8MINK12.55702359
9MARK12.50711210
10RIPK42.25657074
11DAPK22.14753402
12MAP2K42.04619398
13MAP4K22.02919529
14PLK22.01882056
15PNCK1.85389562
16DYRK21.82518816
17CDK191.80558455
18GRK51.73983688
19TRIM281.73431442
20KSR21.70609180
21NTRK11.70093544
22PAK61.68890258
23NTRK21.66898602
24ARAF1.64043799
25CSNK1G31.59550761
26DAPK11.59313140
27MAPK131.55286315
28KSR11.51809624
29TNIK1.45251450
30CSNK1A1L1.43680533
31CDK51.35844684
32BMPR21.32370334
33CSNK1G11.26664444
34SIK21.26545185
35OXSR11.24707155
36CAMKK21.24666329
37PRPF4B1.24596556
38CAMK2A1.18855108
39PRKCG1.18839411
40SIK31.14638922
41ERBB31.12648556
42CCNB11.10980681
43PTK2B1.10476606
44FRK1.08849878
45CAMKK11.04785846
46NME11.03963139
47FES1.02599704
48UHMK10.99581794
49CAMK2B0.98852064
50AKT30.98060250
51MAP3K130.97373122
52SGK2230.96957137
53SGK4940.96957137
54PRKD30.89233956
55GRK70.89101205
56LATS20.84897022
57PKN10.84004461
58CDK180.83975295
59FGR0.82634385
60EPHA30.81995162
61CDK140.81120430
62MAP3K20.80748561
63BCR0.78578499
64CDK150.77236859
65SGK20.75891677
66PHKG10.75853289
67PHKG20.75853289
68RAF10.73687032
69BRAF0.71622584
70PRKCE0.70549596
71TYRO30.68151718
72DYRK1A0.65893881
73CDK11A0.65641797
74DYRK30.64779416
75CSNK1G20.64457713
76ADRBK10.62723700
77BMPR1B0.61071415
78RET0.59549930
79SGK10.59094748
80EPHB20.58911526
81PAK30.58150493
82CAMK2D0.58026619
83CAMK10.57152157
84STK380.56606096
85PDK30.56128646
86PDK40.56128646
87MAP3K60.55843208
88DYRK1B0.55529910
89FER0.54923691
90STK110.54505166
91INSRR0.53132085
92CAMK40.52971211
93MAP2K10.52375379
94ROCK20.52054566
95CAMK2G0.51761571
96STK390.51209965
97MAP3K110.49857839
98LMTK20.49345662
99PRKG10.48312077
100MUSK0.47301996
101ADRBK20.46921675
102LIMK10.46361248
103CSNK1A10.44987121
104TNK20.42908658
105MARK20.42794823
106WNK30.42568010
107TESK10.41978448
108CSNK1D0.41874197
109GRK10.41214165
110PRKCZ0.40526586
111MAP3K10.40302316
112PRKCH0.40117545
113CAMK1G0.38393889
114PINK10.38155361
115PRKCA0.38122354
116CSNK1E0.37759750
117PDPK10.37547437
118SGK30.37252573
119PRKACA0.36160092
120MAPKAPK50.35445632
121DAPK30.35344987
122PDK10.34144418
123RPS6KA30.33043327
124TSSK60.32982365
125MAP3K50.32576904
126PRKCB0.32209772
127WNK40.31469284
128PRKACG0.28418623
129ERBB20.26896468
130FYN0.26433993
131BCKDK0.24981536

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.14700571
2Synaptic vesicle cycle_Homo sapiens_hsa047213.56513245
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.83861537
4Long-term potentiation_Homo sapiens_hsa047202.66304132
5Olfactory transduction_Homo sapiens_hsa047402.58524674
6GABAergic synapse_Homo sapiens_hsa047272.53771491
7Circadian entrainment_Homo sapiens_hsa047132.53299408
8Collecting duct acid secretion_Homo sapiens_hsa049662.53114664
9Amphetamine addiction_Homo sapiens_hsa050312.53099291
10Glutamatergic synapse_Homo sapiens_hsa047242.48503350
11Morphine addiction_Homo sapiens_hsa050322.47214905
12Dopaminergic synapse_Homo sapiens_hsa047282.24759246
13Taste transduction_Homo sapiens_hsa047422.16280195
14Salivary secretion_Homo sapiens_hsa049702.10571609
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03328649
16Serotonergic synapse_Homo sapiens_hsa047261.93322944
17Insulin secretion_Homo sapiens_hsa049111.88262348
18Renin secretion_Homo sapiens_hsa049241.85687327
19Long-term depression_Homo sapiens_hsa047301.80445946
20Oxidative phosphorylation_Homo sapiens_hsa001901.77099662
21Cholinergic synapse_Homo sapiens_hsa047251.76295386
22Gastric acid secretion_Homo sapiens_hsa049711.72335141
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63049750
24Cocaine addiction_Homo sapiens_hsa050301.62257038
25Calcium signaling pathway_Homo sapiens_hsa040201.61048231
26Oxytocin signaling pathway_Homo sapiens_hsa049211.57025650
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55791995
28Vibrio cholerae infection_Homo sapiens_hsa051101.54906533
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48715542
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40050024
31Alzheimers disease_Homo sapiens_hsa050101.38401254
32Cardiac muscle contraction_Homo sapiens_hsa042601.36744653
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35510652
34GnRH signaling pathway_Homo sapiens_hsa049121.34311729
35Gap junction_Homo sapiens_hsa045401.31601073
36Parkinsons disease_Homo sapiens_hsa050121.29235013
37Axon guidance_Homo sapiens_hsa043601.20852261
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.16332007
39Butanoate metabolism_Homo sapiens_hsa006501.13258526
40cAMP signaling pathway_Homo sapiens_hsa040241.13179561
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12259972
42Phototransduction_Homo sapiens_hsa047441.09213849
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03917378
44Estrogen signaling pathway_Homo sapiens_hsa049151.01343433
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01137756
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95817192
47Melanogenesis_Homo sapiens_hsa049160.95589481
48Huntingtons disease_Homo sapiens_hsa050160.94098312
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93609003
50Nitrogen metabolism_Homo sapiens_hsa009100.91310839
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.90361419
52ErbB signaling pathway_Homo sapiens_hsa040120.88713768
53Oocyte meiosis_Homo sapiens_hsa041140.87908517
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86225403
55Glioma_Homo sapiens_hsa052140.84062823
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83510723
57Type II diabetes mellitus_Homo sapiens_hsa049300.79170762
58Protein export_Homo sapiens_hsa030600.77659962
59Pancreatic secretion_Homo sapiens_hsa049720.76460133
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75594142
61Ether lipid metabolism_Homo sapiens_hsa005650.74165546
62Steroid biosynthesis_Homo sapiens_hsa001000.72828220
63Dorso-ventral axis formation_Homo sapiens_hsa043200.69552721
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66249670
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65349856
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63340545
67MAPK signaling pathway_Homo sapiens_hsa040100.63079029
68Rheumatoid arthritis_Homo sapiens_hsa053230.62640958
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61587501
70Thyroid hormone synthesis_Homo sapiens_hsa049180.61339474
71Choline metabolism in cancer_Homo sapiens_hsa052310.59868410
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.58781334
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56887557
74Glucagon signaling pathway_Homo sapiens_hsa049220.55715213
75Dilated cardiomyopathy_Homo sapiens_hsa054140.54700570
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54157472
77Ras signaling pathway_Homo sapiens_hsa040140.53804164
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53592840
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51300244
80VEGF signaling pathway_Homo sapiens_hsa043700.48462495
81African trypanosomiasis_Homo sapiens_hsa051430.47693432
82Alcoholism_Homo sapiens_hsa050340.47164230
83Phagosome_Homo sapiens_hsa041450.45982302
84Fatty acid elongation_Homo sapiens_hsa000620.45396048
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44444452
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.43857437
87beta-Alanine metabolism_Homo sapiens_hsa004100.43535944
88Circadian rhythm_Homo sapiens_hsa047100.42737445
89Inositol phosphate metabolism_Homo sapiens_hsa005620.42385790
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40949944
91Rap1 signaling pathway_Homo sapiens_hsa040150.40418039
92Linoleic acid metabolism_Homo sapiens_hsa005910.39734466
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.39602876
94Type I diabetes mellitus_Homo sapiens_hsa049400.39285296
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38020471
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37250918
97Prion diseases_Homo sapiens_hsa050200.36805650
98Ovarian steroidogenesis_Homo sapiens_hsa049130.34916785
99Wnt signaling pathway_Homo sapiens_hsa043100.34682554
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32755305
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31138684
102Renal cell carcinoma_Homo sapiens_hsa052110.30869824
103Bile secretion_Homo sapiens_hsa049760.30135874
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30098229
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29958765
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29352121
107Fatty acid biosynthesis_Homo sapiens_hsa000610.28131586
108Peroxisome_Homo sapiens_hsa041460.27140134
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26420788
110Endocytosis_Homo sapiens_hsa041440.25783917
111Arginine and proline metabolism_Homo sapiens_hsa003300.25490757
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25048444
113Regulation of autophagy_Homo sapiens_hsa041400.24864254
114Maturity onset diabetes of the young_Homo sapiens_hsa049500.24858614
115Insulin signaling pathway_Homo sapiens_hsa049100.24784430
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24491426
117Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24343546
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.24165419
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23390323
120Vitamin B6 metabolism_Homo sapiens_hsa007500.23159598
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.23076942
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.21750946
123Hippo signaling pathway_Homo sapiens_hsa043900.21608491

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »