ATHL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)6.19241224
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.19241224
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.91252756
4L-phenylalanine catabolic process (GO:0006559)5.91252756
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.86965499
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.75506279
7L-phenylalanine metabolic process (GO:0006558)5.75506279
8positive regulation of gamma-delta T cell activation (GO:0046645)5.58171745
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.57737594
10antigen processing and presentation of endogenous antigen (GO:0019883)5.48045291
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.43828413
12aromatic amino acid family catabolic process (GO:0009074)5.32471407
13alpha-linolenic acid metabolic process (GO:0036109)5.25311607
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.22389390
15negative thymic T cell selection (GO:0045060)5.20795437
16glyoxylate metabolic process (GO:0046487)5.06295053
17sulfur amino acid catabolic process (GO:0000098)5.04472847
18negative T cell selection (GO:0043383)5.02076332
19tolerance induction (GO:0002507)5.01923412
20positive thymic T cell selection (GO:0045059)4.90019830
21regulation of gamma-delta T cell differentiation (GO:0045586)4.89897924
22tryptophan catabolic process (GO:0006569)4.84734696
23indole-containing compound catabolic process (GO:0042436)4.84734696
24indolalkylamine catabolic process (GO:0046218)4.84734696
25thymic T cell selection (GO:0045061)4.78784681
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.76257857
27leukocyte aggregation (GO:0070486)4.76102137
28regulation of gamma-delta T cell activation (GO:0046643)4.74328533
29kynurenine metabolic process (GO:0070189)4.72222650
30bile acid biosynthetic process (GO:0006699)4.69902384
31tryptophan metabolic process (GO:0006568)4.59237111
32cysteine metabolic process (GO:0006534)4.59204009
33positive T cell selection (GO:0043368)4.52243400
34response to interleukin-15 (GO:0070672)4.50830834
35negative regulation of erythrocyte differentiation (GO:0045647)4.45479139
36peptidyl-glutamic acid carboxylation (GO:0017187)4.45453592
37protein carboxylation (GO:0018214)4.45453592
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.41447523
39T cell selection (GO:0045058)4.41401128
40negative regulation of fibrinolysis (GO:0051918)4.38235879
41response to muramyl dipeptide (GO:0032495)4.37156810
42complement activation, alternative pathway (GO:0006957)4.35997372
43lysine metabolic process (GO:0006553)4.33573155
44lysine catabolic process (GO:0006554)4.33573155
45urea cycle (GO:0000050)4.32068577
46urea metabolic process (GO:0019627)4.32068577
47regulation of protein activation cascade (GO:2000257)4.31735113
48high-density lipoprotein particle remodeling (GO:0034375)4.27210023
49homocysteine metabolic process (GO:0050667)4.22430934
50serine family amino acid catabolic process (GO:0009071)4.19839432
51negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.16972034
52positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.13454852
53regulation of fibrinolysis (GO:0051917)4.10392002
54regulation of cholesterol esterification (GO:0010872)4.10207387
55regulation of complement activation (GO:0030449)4.09544420
56regulation of B cell receptor signaling pathway (GO:0050855)4.09443802
57amino-acid betaine metabolic process (GO:0006577)4.06451288
58negative regulation of sterol transport (GO:0032372)4.06120169
59negative regulation of cholesterol transport (GO:0032375)4.06120169
60NIK/NF-kappaB signaling (GO:0038061)3.97519867
61regulation of triglyceride catabolic process (GO:0010896)3.97462793
62bile acid metabolic process (GO:0008206)3.93723822
63glycine metabolic process (GO:0006544)3.93628618
64positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.92930373
65nitrogen cycle metabolic process (GO:0071941)3.91864736
66detection of bacterium (GO:0016045)3.90798723
67reverse cholesterol transport (GO:0043691)3.87150000
68phospholipid efflux (GO:0033700)3.87119841
69plasma lipoprotein particle remodeling (GO:0034369)3.84810794
70protein-lipid complex remodeling (GO:0034368)3.84810794
71macromolecular complex remodeling (GO:0034367)3.84810794
72detection of other organism (GO:0098543)3.81749320
73valine metabolic process (GO:0006573)3.76846627
74aromatic amino acid family metabolic process (GO:0009072)3.76366268
75ethanol oxidation (GO:0006069)3.75534449
76cellular modified amino acid catabolic process (GO:0042219)3.74058534
77germinal center formation (GO:0002467)3.71446204
78cellular response to interleukin-15 (GO:0071350)3.68046982
79alpha-amino acid catabolic process (GO:1901606)3.66624392
80serine family amino acid biosynthetic process (GO:0009070)3.66012027
81negative regulation of lymphocyte mediated immunity (GO:0002707)3.65015434
82acylglycerol homeostasis (GO:0055090)3.64719901
83triglyceride homeostasis (GO:0070328)3.64719901
84serine family amino acid metabolic process (GO:0009069)3.63781372
85plasma lipoprotein particle clearance (GO:0034381)3.63364379
86negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.63016292
87tyrosine metabolic process (GO:0006570)3.62274953
88amine catabolic process (GO:0009310)3.60589244
89cellular biogenic amine catabolic process (GO:0042402)3.60589244
90regulation of cholesterol homeostasis (GO:2000188)3.60494600
91T cell migration (GO:0072678)3.59562167
92imidazole-containing compound metabolic process (GO:0052803)3.56618308
93modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.56604303
94positive regulation by organism of defense response of other organism involved in symbiotic interact3.56604303
95modulation by symbiont of host immune response (GO:0052553)3.56604303
96positive regulation by symbiont of host defense response (GO:0052509)3.56604303
97modulation by symbiont of host defense response (GO:0052031)3.56604303
98modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.56604303
99regulation of T cell tolerance induction (GO:0002664)3.55398500
100negative regulation of T-helper cell differentiation (GO:0045623)3.53653846
101negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.53653846
102low-density lipoprotein particle remodeling (GO:0034374)3.53516010
103plasma lipoprotein particle assembly (GO:0034377)3.52472587
104cellular amino acid catabolic process (GO:0009063)3.47093573
105cellular glucuronidation (GO:0052695)3.45172792
106regulation of alpha-beta T cell proliferation (GO:0046640)3.41325191
107positive regulation of fatty acid beta-oxidation (GO:0032000)3.40689479
108histone H3-K36 demethylation (GO:0070544)3.38912051
109activated T cell proliferation (GO:0050798)3.37308408
110mannose metabolic process (GO:0006013)3.37266541
111negative regulation of leukocyte mediated immunity (GO:0002704)3.36581725
112coenzyme catabolic process (GO:0009109)3.34213216
113fatty acid beta-oxidation (GO:0006635)3.30677324
114B cell receptor signaling pathway (GO:0050853)3.30414219
115macrophage activation involved in immune response (GO:0002281)3.28216552
116indolalkylamine metabolic process (GO:0006586)3.28089970
117positive regulation of granulocyte differentiation (GO:0030854)3.27609347
118benzene-containing compound metabolic process (GO:0042537)3.27276713
119positive regulation of lipid catabolic process (GO:0050996)3.25780220
120urate metabolic process (GO:0046415)3.25095237
121negative regulation of innate immune response (GO:0045824)3.25062299
122bile acid and bile salt transport (GO:0015721)3.21322480
123positive regulation of triglyceride metabolic process (GO:0090208)3.20837266
124regulation of plasminogen activation (GO:0010755)3.20772064
125cellular extravasation (GO:0045123)3.20519610
126fatty acid oxidation (GO:0019395)3.19200119
127response to type I interferon (GO:0034340)3.18805534
128cholesterol efflux (GO:0033344)3.18190320
129carnitine metabolic process (GO:0009437)3.17400058
130antigen processing and presentation via MHC class Ib (GO:0002475)3.17186490
131regulation of cholesterol metabolic process (GO:0090181)3.16934829
132cellular response to type I interferon (GO:0071357)3.16469365
133type I interferon signaling pathway (GO:0060337)3.16469365
1342-oxoglutarate metabolic process (GO:0006103)3.15996152
135lipid oxidation (GO:0034440)3.15421771
136protein-lipid complex assembly (GO:0065005)3.15395501
137carboxylic acid catabolic process (GO:0046395)3.15143130
138organic acid catabolic process (GO:0016054)3.15143130
139regulation of cholesterol biosynthetic process (GO:0045540)3.13006936
140negative regulation of glycoprotein biosynthetic process (GO:0010561)3.12817035
141plasma lipoprotein particle organization (GO:0071827)3.12799112
142fibrinolysis (GO:0042730)3.11310576
143regulation of B cell differentiation (GO:0045577)3.10119522
144regulation of tolerance induction (GO:0002643)3.10036389
145positive regulation of lipoprotein lipase activity (GO:0051006)3.10007549
146positive regulation of triglyceride lipase activity (GO:0061365)3.10007549
147glutamate metabolic process (GO:0006536)3.07936933
148epoxygenase P450 pathway (GO:0019373)3.07275080
149response to nitrosative stress (GO:0051409)3.06883574
150monocarboxylic acid catabolic process (GO:0072329)3.06479294
151negative regulation of T cell mediated immunity (GO:0002710)3.06361251
152short-chain fatty acid metabolic process (GO:0046459)3.06143978
153T cell homeostasis (GO:0043029)3.05763995
154fatty acid catabolic process (GO:0009062)3.03513489
155cholesterol homeostasis (GO:0042632)3.03226678
156lipoprotein metabolic process (GO:0042157)3.02891770
157B cell homeostasis (GO:0001782)3.02888681
158positive regulation of B cell differentiation (GO:0045579)3.02242201
159complement activation (GO:0006956)2.99799128
160negative regulation of interleukin-12 production (GO:0032695)2.99763571
161regulation of dendritic cell antigen processing and presentation (GO:0002604)2.99696406
162regulation of fatty acid beta-oxidation (GO:0031998)2.99493304
163detection of external biotic stimulus (GO:0098581)2.99437359
164uronic acid metabolic process (GO:0006063)2.98774428
165glucuronate metabolic process (GO:0019585)2.98774428
166regulation of natural killer cell mediated immunity (GO:0002715)2.98686062
167regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.98686062
168sterol homeostasis (GO:0055092)2.96810911
169regulation of interferon-beta biosynthetic process (GO:0045357)2.95099636
170lymphocyte homeostasis (GO:0002260)2.95024828
171defense response to protozoan (GO:0042832)2.93966587
172response to laminar fluid shear stress (GO:0034616)2.92508262
173negative regulation of alpha-beta T cell activation (GO:0046636)2.91564156
174regulation of interleukin-2 biosynthetic process (GO:0045076)2.91314873
175regulation of histone H3-K27 methylation (GO:0061085)2.90532564
176T cell receptor signaling pathway (GO:0050852)2.90081775
177neutrophil activation involved in immune response (GO:0002283)2.89641775
178antigen receptor-mediated signaling pathway (GO:0050851)2.89277668
179regulation of regulatory T cell differentiation (GO:0045589)2.88321846
180immunoglobulin mediated immune response (GO:0016064)2.85759040
181mucosal-associated lymphoid tissue development (GO:0048537)2.84847745
182Peyers patch development (GO:0048541)2.84847745
183regulation of type I interferon-mediated signaling pathway (GO:0060338)2.84508273
184natural killer cell differentiation (GO:0001779)2.84397536
185regulation of T cell mediated cytotoxicity (GO:0001914)2.83965832
186positive regulation of tolerance induction (GO:0002645)2.81440780
187positive regulation of Rap GTPase activity (GO:0032854)2.80517083
188regulation of granulocyte differentiation (GO:0030852)2.76603333
189positive regulation of T cell mediated cytotoxicity (GO:0001916)2.75279808
190JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.75098413
191myeloid dendritic cell differentiation (GO:0043011)2.73583828
192negative regulation of bone resorption (GO:0045779)2.69947578
193negative regulation of type 2 immune response (GO:0002829)2.69839768
194alpha-beta T cell differentiation (GO:0046632)2.69425157
195positive regulation of interleukin-2 production (GO:0032743)2.66912146
196phospholipid scrambling (GO:0017121)2.65808498
197positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.65806182
198interferon-gamma production (GO:0032609)2.65750734
199negative regulation of toll-like receptor signaling pathway (GO:0034122)2.64717781
200positive regulation of T cell differentiation in thymus (GO:0033089)2.64655489

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.59243462
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.10013882
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.44603378
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.61740624
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.58349029
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.57336326
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.70880983
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.68107431
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.52298870
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.99025632
11* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.72911534
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.69975839
13KDM2B_26808549_Chip-Seq_DND41_Human2.59896091
14RUNX_20019798_ChIP-Seq_JUKART_Human2.59380969
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.43330311
16* MAF_26560356_Chip-Seq_TH2_Human2.32485764
17CLOCK_20551151_ChIP-Seq_293T_Human2.27725839
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.26445624
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.22037407
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19293099
21TP63_17297297_ChIP-ChIP_HaCaT_Human2.11366165
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.09895388
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.06532668
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.02052164
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00979695
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.88534712
27* KDM2B_26808549_Chip-Seq_JURKAT_Human1.87855485
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86040066
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.84157560
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.81251551
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.71149593
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69541678
33SPI1_23127762_ChIP-Seq_K562_Human1.67947451
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67611429
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67538663
36SPI1_23547873_ChIP-Seq_NB4_Human1.67505366
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62920997
38GATA1_22025678_ChIP-Seq_K562_Human1.59844011
39TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.55351736
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.55052585
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.48956308
42E2F7_22180533_ChIP-Seq_HELA_Human1.47886850
43GATA3_27048872_Chip-Seq_THYMUS_Human1.45249988
44* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.42352879
45SCL_19346495_ChIP-Seq_HPC-7_Human1.40299138
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39626163
47SA1_27219007_Chip-Seq_ERYTHROID_Human1.38340818
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37795804
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37590526
50GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37429423
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35767195
52MYC_22102868_ChIP-Seq_BL_Human1.31855899
53VDR_21846776_ChIP-Seq_THP-1_Human1.31830602
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30103232
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29665523
56CIITA_25753668_ChIP-Seq_RAJI_Human1.29039278
57* P68_20966046_ChIP-Seq_HELA_Human1.29034640
58KDM2B_26808549_Chip-Seq_K562_Human1.27411594
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24808128
60PU.1_20513432_ChIP-Seq_Bcells_Mouse1.24600664
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24045528
62BCOR_27268052_Chip-Seq_Bcells_Human1.21068446
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19923188
64* LXR_22292898_ChIP-Seq_THP-1_Human1.19624479
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19357979
66* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18113118
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16944455
68MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15712271
69BCL6_27268052_Chip-Seq_Bcells_Human1.15504933
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.14113856
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.12514934
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11960082
73PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10587499
74GATA1_19941826_ChIP-Seq_K562_Human1.07823728
75* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06404498
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04819885
77CREB1_26743006_Chip-Seq_LNCaP_Human1.03358184
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02995056
79NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02729263
80RUNX1_27514584_Chip-Seq_MCF-7_Human1.02509666
81* MAF_26560356_Chip-Seq_TH1_Human1.02296319
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01991811
83RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01912929
84SMC4_20622854_ChIP-Seq_HELA_Human1.00959855
85ESR1_21235772_ChIP-Seq_MCF-7_Human0.99494531
86* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98783966
87CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98440362
88E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98403272
89* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97471124
90FOXA2_19822575_ChIP-Seq_HepG2_Human0.97227467
91CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96324573
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96146795
93SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95980801
94PU_27001747_Chip-Seq_BMDM_Mouse0.95371288
95NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94031739
96HNF4A_19822575_ChIP-Seq_HepG2_Human0.93775100
97TCF7_22412390_ChIP-Seq_EML_Mouse0.93494709
98CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92090018
99VDR_24787735_ChIP-Seq_THP-1_Human0.92070254
100GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91770051
101TET1_21451524_ChIP-Seq_MESCs_Mouse0.91443687
102RACK7_27058665_Chip-Seq_MCF-7_Human0.90757106
103RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89753076
104SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.89274097
105CTCF_26484167_Chip-Seq_Bcells_Mouse0.88973033
106GATA4_25053715_ChIP-Seq_YYC3_Human0.88391892
107ELF1_17652178_ChIP-ChIP_JURKAT_Human0.88286330
108PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87517697
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87153955
110* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86477933
111STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.85846585
112* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85096959
113ESR2_21235772_ChIP-Seq_MCF-7_Human0.84824896
114NOTCH1_21737748_ChIP-Seq_TLL_Human0.84708942
115HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84401716
116RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82848294
117TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.81848196
118TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80476240
119UTX_26944678_Chip-Seq_JUKART_Human0.79944326
120TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.79346509
121SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.79043318
122AR_21909140_ChIP-Seq_LNCAP_Human0.78708528
123SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.77539102
124RUNX1_22412390_ChIP-Seq_EML_Mouse0.77464188
125MYB_26560356_Chip-Seq_TH1_Human0.77145074
126VDR_24763502_ChIP-Seq_THP-1_Human0.76642730
127RARB_24833708_ChIP-Seq_LIVER_Mouse0.76437659
128FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.76132794
129ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.76020271
130KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.74274497
131* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.73666213
132GATA2_22383799_ChIP-Seq_G1ME_Mouse0.73648948
133GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.72997853
134NCOR1_26117541_ChIP-Seq_K562_Human0.72232196
135MYB_26560356_Chip-Seq_TH2_Human0.71556676
136CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71098290
137IRF8_21731497_ChIP-ChIP_J774_Mouse0.70488194
138CDX2_20551321_ChIP-Seq_CACO-2_Human0.70213353
139RARA_24833708_ChIP-Seq_LIVER_Mouse0.69873859
140ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.69423065
141TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.69396177
142TRIM28_21343339_ChIP-Seq_HEK293_Human0.69165009
143KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.68651086
144* GATA1_19941827_ChIP-Seq_MEL_Mouse0.68322546
145* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.68220189
146GATA6_25053715_ChIP-Seq_YYC3_Human0.67636565
147IRF8_27001747_Chip-Seq_BMDM_Mouse0.67407497
148ATF3_27146783_Chip-Seq_COLON_Human0.66794622

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.13075238
2MP0005360_urolithiasis5.64828633
3MP0005365_abnormal_bile_salt4.99694167
4MP0005085_abnormal_gallbladder_physiolo4.58815446
5MP0003763_abnormal_thymus_physiology4.05256738
6MP0008875_abnormal_xenobiotic_pharmacok3.55308252
7MP0003806_abnormal_nucleotide_metabolis3.37803895
8MP0003252_abnormal_bile_duct3.10892718
9MP0010329_abnormal_lipoprotein_level2.84973359
10MP0009840_abnormal_foam_cell2.81308400
11MP0005671_abnormal_response_to2.79428272
12MP0005000_abnormal_immune_tolerance2.68341934
13MP0003303_peritoneal_inflammation2.65760529
14MP0009333_abnormal_splenocyte_physiolog2.51065225
15MP0002723_abnormal_immune_serum2.46887629
16MP0002420_abnormal_adaptive_immunity2.43090174
17MP0001819_abnormal_immune_cell2.41501639
18MP0001873_stomach_inflammation2.37476053
19MP0005332_abnormal_amino_acid2.37341456
20MP0002452_abnormal_antigen_presenting2.32583456
21MP0005083_abnormal_biliary_tract2.23115196
22MP0008260_abnormal_autophagy2.22197211
23MP0001666_abnormal_nutrient_absorption2.19071553
24MP0002398_abnormal_bone_marrow2.15214133
25MP0000703_abnormal_thymus_morphology2.12983369
26MP0003191_abnormal_cellular_cholesterol2.09953880
27MP0002405_respiratory_system_inflammati2.07764486
28MP0003172_abnormal_lysosome_physiology2.05621278
29MP0003705_abnormal_hypodermis_morpholog2.05493532
30MP0000716_abnormal_immune_system1.99991060
31MP0004381_abnormal_hair_follicle1.98177444
32MP0000609_abnormal_liver_physiology1.95044175
33MP0003866_abnormal_defecation1.93277533
34MP0003195_calcinosis1.91650897
35MP0005670_abnormal_white_adipose1.88254497
36MP0002722_abnormal_immune_system1.76411663
37MP0002138_abnormal_hepatobiliary_system1.73728627
38MP0004510_myositis1.73561748
39MP0000689_abnormal_spleen_morphology1.73279444
40MP0005319_abnormal_enzyme/_coenzyme1.65283848
41MP0004019_abnormal_vitamin_homeostasis1.64198755
42MP0002118_abnormal_lipid_homeostasis1.61049303
43MP0002429_abnormal_blood_cell1.59859320
44MP0002148_abnormal_hypersensitivity_rea1.57412434
45MP0005310_abnormal_salivary_gland1.51956857
46MP0008438_abnormal_cutaneous_collagen1.50804108
47MP0003186_abnormal_redox_activity1.45218145
48MP0009643_abnormal_urine_homeostasis1.43203349
49MP0001851_eye_inflammation1.34534165
50MP0005584_abnormal_enzyme/coenzyme_acti1.32407179
51MP0003868_abnormal_feces_composition1.32087169
52MP0002998_abnormal_bone_remodeling1.31222324
53MP0003436_decreased_susceptibility_to1.30795297
54MP0000685_abnormal_immune_system1.29226450
55MP0010368_abnormal_lymphatic_system1.27870547
56MP0005076_abnormal_cell_differentiation1.26482901
57MP0002254_reproductive_system_inflammat1.26269615
58MP0000465_gastrointestinal_hemorrhage1.24778438
59MP0002009_preneoplasia1.23384371
60MP0000598_abnormal_liver_morphology1.22845519
61MP0000858_altered_metastatic_potential1.22199487
62MP0001764_abnormal_homeostasis1.19029403
63MP0009764_decreased_sensitivity_to1.18636422
64MP0003300_gastrointestinal_ulcer1.17993516
65MP0003828_pulmonary_edema1.17222582
66MP0001853_heart_inflammation1.12280156
67MP0003011_delayed_dark_adaptation1.12005431
68MP0008961_abnormal_basal_metabolism1.10931131
69MP0008469_abnormal_protein_level1.07819411
70MP0001348_abnormal_lacrimal_gland1.05425112
71MP0005220_abnormal_exocrine_pancreas1.04962945
72MP0001849_ear_inflammation1.04880832
73MP0005464_abnormal_platelet_physiology1.04414066
74MP0003724_increased_susceptibility_to1.03505149
75MP0009763_increased_sensitivity_to1.02932730
76MP0004808_abnormal_hematopoietic_stem1.01110259
77MP0005666_abnormal_adipose_tissue0.99921640
78MP0003656_abnormal_erythrocyte_physiolo0.99146753
79MP0003279_aneurysm0.95848076
80MP0004883_abnormal_blood_vessel0.95450626
81MP0005023_abnormal_wound_healing0.92189026
82MP0002132_abnormal_respiratory_system0.91899527
83MP0001663_abnormal_digestive_system0.90881990
84MP0000490_abnormal_crypts_of0.90790809
85MP0003091_abnormal_cell_migration0.90683639
86MP0009697_abnormal_copulation0.90134800
87MP0002060_abnormal_skin_morphology0.89191576
88MP0003183_abnormal_peptide_metabolism0.88883393
89MP0003075_altered_response_to0.88514760
90MP0006054_spinal_hemorrhage0.85427584
91MP0009384_cardiac_valve_regurgitation0.83306479
92MP0002277_abnormal_respiratory_mucosa0.83254841
93MP0002166_altered_tumor_susceptibility0.82946744
94MP0005390_skeleton_phenotype0.81722886
95MP0005075_abnormal_melanosome_morpholog0.80974372
96MP0001835_abnormal_antigen_presentation0.80645627
97MP0009642_abnormal_blood_homeostasis0.78611798
98MP0009053_abnormal_anal_canal0.77844481
99MP0010155_abnormal_intestine_physiology0.77185684
100MP0003448_altered_tumor_morphology0.76913298
101MP0009785_altered_susceptibility_to0.76643294
102MP0003566_abnormal_cell_adhesion0.75806211
103MP0005275_abnormal_skin_tensile0.74771077
104MP0005451_abnormal_body_composition0.74601086
105MP0005058_abnormal_lysosome_morphology0.74308277
106MP0004185_abnormal_adipocyte_glucose0.74228503
107MP0002136_abnormal_kidney_physiology0.73846904
108MP0005636_abnormal_mineral_homeostasis0.73721889
109MP0003795_abnormal_bone_structure0.73686737
110MP0003045_fibrosis0.73161463
111MP0004264_abnormal_extraembryonic_tissu0.72802048
112MP0008995_early_reproductive_senescence0.71208522
113MP0001845_abnormal_inflammatory_respons0.71060782
114MP0004130_abnormal_muscle_cell0.70889169
115MP0001545_abnormal_hematopoietic_system0.70712273
116MP0005397_hematopoietic_system_phenotyp0.70712273
117MP0002396_abnormal_hematopoietic_system0.70168034
118MP0002928_abnormal_bile_duct0.69946088
119MP0005166_decreased_susceptibility_to0.68002154
120MP0005647_abnormal_sex_gland0.67304462
121MP0009278_abnormal_bone_marrow0.66922408
122MP0002971_abnormal_brown_adipose0.66508588
123MP0002006_tumorigenesis0.66219110
124MP0005025_abnormal_response_to0.66104828
125MP0004947_skin_inflammation0.65851294
126MP0005334_abnormal_fat_pad0.65652749
127MP0002019_abnormal_tumor_incidence0.65325499
128MP0001533_abnormal_skeleton_physiology0.64702676
129MP0009765_abnormal_xenobiotic_induced0.64608781
130MP0002249_abnormal_larynx_morphology0.64168788
131MP0001756_abnormal_urination0.63614603
132MP0002419_abnormal_innate_immunity0.61900415
133MP0005376_homeostasis/metabolism_phenot0.60862363
134MP0009115_abnormal_fat_cell0.60327835
135MP0000604_amyloidosis0.59949259
136MP0002135_abnormal_kidney_morphology0.59710662
137MP0001879_abnormal_lymphatic_vessel0.59526104
138MP0000249_abnormal_blood_vessel0.58812227
139MP0001800_abnormal_humoral_immune0.58724731
140MP0003690_abnormal_glial_cell0.58533418
141MP0008004_abnormal_stomach_pH0.58368540
142MP0005164_abnormal_response_to0.57489284
143MP0006036_abnormal_mitochondrial_physio0.56986330
144MP0005535_abnormal_body_temperature0.56638270
145MP0002078_abnormal_glucose_homeostasis0.56411323
146MP0005381_digestive/alimentary_phenotyp0.56239641
147MP0010352_gastrointestinal_tract_polyps0.56131434
148MP0001243_abnormal_dermal_layer0.55111938
149MP0000371_diluted_coat_color0.54528608
150MP0001790_abnormal_immune_system0.54473297
151MP0005387_immune_system_phenotype0.54473297
152MP0002933_joint_inflammation0.54464988
153MP0002168_other_aberrant_phenotype0.53849102
154MP0003453_abnormal_keratinocyte_physiol0.53072307
155MP0000767_abnormal_smooth_muscle0.52706918
156MP0006082_CNS_inflammation0.52553271

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.57197699
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.00203780
3Intrahepatic cholestasis (HP:0001406)5.80930706
4Deep venous thrombosis (HP:0002625)5.75943942
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.43755136
6Xanthomatosis (HP:0000991)5.36759002
7Hypobetalipoproteinemia (HP:0003563)4.84720605
8Prolonged partial thromboplastin time (HP:0003645)4.74087812
9Pustule (HP:0200039)4.52673785
10Hyperlipoproteinemia (HP:0010980)4.43419944
11Panhypogammaglobulinemia (HP:0003139)4.38835099
12Myositis (HP:0100614)4.33772787
13Abnormal delayed hypersensitivity skin test (HP:0002963)4.24463929
14Complement deficiency (HP:0004431)4.19294198
15Elevated erythrocyte sedimentation rate (HP:0003565)4.00908253
16Increased IgE level (HP:0003212)4.00521860
17Abnormality of the common coagulation pathway (HP:0010990)3.96310001
18Obstructive sleep apnea (HP:0002870)3.95505138
19Hypoglycemic coma (HP:0001325)3.92153704
20Recurrent fungal infections (HP:0002841)3.91358607
21Ketosis (HP:0001946)3.88563429
22Hyperammonemia (HP:0001987)3.83837280
23Abnormality of glutamine family amino acid metabolism (HP:0010902)3.82438835
24Stomatitis (HP:0010280)3.75260027
25Orchitis (HP:0100796)3.71173142
26Hypolipoproteinemia (HP:0010981)3.70223157
27Abnormality of sulfur amino acid metabolism (HP:0004339)3.69307479
28Joint hemorrhage (HP:0005261)3.68138657
29Hyperglycinuria (HP:0003108)3.67613209
30Recurrent abscess formation (HP:0002722)3.65754730
31Recurrent bacterial skin infections (HP:0005406)3.59505742
32Abnormality of macrophages (HP:0004311)3.56994020
33Gastrointestinal infarctions (HP:0005244)3.49024691
34Retrobulbar optic neuritis (HP:0100654)3.47730949
35Optic neuritis (HP:0100653)3.47730949
36Meningitis (HP:0001287)3.45754243
37Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.44103923
38Hyperglycinemia (HP:0002154)3.43881304
39Abnormality of the intrinsic pathway (HP:0010989)3.42158211
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.41335702
41Abnormality of serine family amino acid metabolism (HP:0010894)3.39362561
42Abnormality of glycine metabolism (HP:0010895)3.39362561
43Abnormality of fatty-acid metabolism (HP:0004359)3.34794405
44T lymphocytopenia (HP:0005403)3.34696196
45Abnormality of pyrimidine metabolism (HP:0004353)3.31027015
46Hypoalphalipoproteinemia (HP:0003233)3.30591571
47Abnormality of aspartate family amino acid metabolism (HP:0010899)3.29537919
48Fat malabsorption (HP:0002630)3.23058834
49Abnormality of methionine metabolism (HP:0010901)3.21383983
50Epidermoid cyst (HP:0200040)3.20628528
51Abnormality of complement system (HP:0005339)3.19329993
52Mediastinal lymphadenopathy (HP:0100721)3.18059412
53Abnormality of the fingertips (HP:0001211)3.17553598
54Myocardial infarction (HP:0001658)3.17190447
55Vasculitis (HP:0002633)3.12383502
56Chronic obstructive pulmonary disease (HP:0006510)3.11082765
57Obstructive lung disease (HP:0006536)3.11082765
58Spontaneous hematomas (HP:0007420)3.10022286
59Prolonged bleeding time (HP:0003010)3.08551081
60Abnormality of T cell number (HP:0011839)3.06248302
61Ketoacidosis (HP:0001993)3.04297793
62Hypercholesterolemia (HP:0003124)3.02641556
63Recurrent viral infections (HP:0004429)3.02557797
64Encephalitis (HP:0002383)2.95467920
65Gastrointestinal inflammation (HP:0004386)2.95156032
66Cellulitis (HP:0100658)2.93603493
67Gingivitis (HP:0000230)2.92824762
68Verrucae (HP:0200043)2.91805614
69Papilloma (HP:0012740)2.91805614
70Granulocytopenia (HP:0001913)2.87063678
71Abnormality of T cells (HP:0002843)2.85608762
72Colitis (HP:0002583)2.84269109
73Abnormality of nucleobase metabolism (HP:0010932)2.84239131
74Papilledema (HP:0001085)2.83392300
75Recurrent cutaneous fungal infections (HP:0011370)2.83265709
76Chronic mucocutaneous candidiasis (HP:0002728)2.83265709
77Broad face (HP:0000283)2.83224411
78Inflammation of the large intestine (HP:0002037)2.82844037
79Lymphopenia (HP:0001888)2.82349166
80Spastic diplegia (HP:0001264)2.80173799
81Hyperbilirubinemia (HP:0002904)2.76417167
82Gastrointestinal stroma tumor (HP:0100723)2.73613349
83Seborrheic dermatitis (HP:0001051)2.68298134
84Chest pain (HP:0100749)2.63703858
85Abnormality of purine metabolism (HP:0004352)2.60845189
86Severe combined immunodeficiency (HP:0004430)2.59995155
87Recurrent skin infections (HP:0001581)2.59596198
88Abnormality of cells of the lymphoid lineage (HP:0012140)2.58955656
89Pulmonary infiltrates (HP:0002113)2.58469990
90Basal cell carcinoma (HP:0002671)2.57987036
91Keratoconjunctivitis sicca (HP:0001097)2.56527360
92Esophageal varix (HP:0002040)2.55075766
93Late onset (HP:0003584)2.54669426
94Hepatocellular carcinoma (HP:0001402)2.54228418
95Generalized aminoaciduria (HP:0002909)2.52989908
96Delayed CNS myelination (HP:0002188)2.49351539
97Hemoptysis (HP:0002105)2.49072011
98Systemic lupus erythematosus (HP:0002725)2.47777856
99Segmental peripheral demyelination/remyelination (HP:0003481)2.47496582
100Agammaglobulinemia (HP:0004432)2.45403400
101Steatorrhea (HP:0002570)2.44992355
102Conjugated hyperbilirubinemia (HP:0002908)2.44394529
103Thin bony cortex (HP:0002753)2.43096875
104Abnormality of T cell physiology (HP:0011840)2.42593925
105Alopecia of scalp (HP:0002293)2.41135576
106Leukocytosis (HP:0001974)2.38902542
107Gingival bleeding (HP:0000225)2.38811506
108Slow saccadic eye movements (HP:0000514)2.34777221
109Dicarboxylic aciduria (HP:0003215)2.34184557
110Abnormality of dicarboxylic acid metabolism (HP:0010995)2.34184557
111Hypoglycemic seizures (HP:0002173)2.34102557
112Abnormality of proline metabolism (HP:0010907)2.33831289
113Hydroxyprolinuria (HP:0003080)2.33831289
114Emphysema (HP:0002097)2.32915688
115Mitral stenosis (HP:0001718)2.32487576
116Increased IgM level (HP:0003496)2.31552226
117Hypochromic anemia (HP:0001931)2.31046911
118Keratoconjunctivitis (HP:0001096)2.30199706
119Spinal canal stenosis (HP:0003416)2.27191197
120Recurrent bronchitis (HP:0002837)2.25507232
121Gout (HP:0001997)2.25171152
122Premature loss of primary teeth (HP:0006323)2.22097874
123Amyloidosis (HP:0011034)2.21501373
124Osteomyelitis (HP:0002754)2.21421456
125Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.19740973
126Abnormality of serum amino acid levels (HP:0003112)2.19343018
127Skin nodule (HP:0200036)2.17362474
128Menorrhagia (HP:0000132)2.16701262
129Easy fatigability (HP:0003388)2.16408850
130Abnormal cartilage morphology (HP:0002763)2.15595077
131Eosinophilia (HP:0001880)2.15588264
132Glomerulonephritis (HP:0000099)2.15006323
133IgM deficiency (HP:0002850)2.14996834
134Thrombophlebitis (HP:0004418)2.14846728
135Metabolic acidosis (HP:0001942)2.10950397
136Protrusio acetabuli (HP:0003179)2.10037327
137Hypergammaglobulinemia (HP:0010702)2.09985731
138Restrictive lung disease (HP:0002091)2.09843966
139Pulmonary embolism (HP:0002204)2.09765952
140Recurrent gram-negative bacterial infections (HP:0005420)2.09715978
141Nausea (HP:0002018)2.08272608
142Viral hepatitis (HP:0006562)2.07186112
143Vascular calcification (HP:0004934)2.03101274
144Spontaneous abortion (HP:0005268)2.01253685
145Combined immunodeficiency (HP:0005387)2.00716437
146Hypertriglyceridemia (HP:0002155)1.98313345
147Polycythemia (HP:0001901)1.97815476
148Dislocated radial head (HP:0003083)1.96792827
149Abnormality of eosinophils (HP:0001879)1.96615309
150Cardiovascular calcification (HP:0011915)1.96408490
151Abnormality of iron homeostasis (HP:0011031)1.95934973
152Pancreatitis (HP:0001733)1.95433748
153Nephritis (HP:0000123)1.95061254
154Urticaria (HP:0001025)1.94793970
155Abnormality of transition element cation homeostasis (HP:0011030)1.94304860
156Hypochromic microcytic anemia (HP:0004840)1.93265209
157Subacute progressive viral hepatitis (HP:0006572)1.92981281
158Abnormal enzyme/coenzyme activity (HP:0012379)1.92559405
159Enlarged kidneys (HP:0000105)1.91875927
160Dysostosis multiplex (HP:0000943)1.90451991
161Ectopia lentis (HP:0001083)1.89234400
162Peritonitis (HP:0002586)1.88595422
163Metaphyseal cupping (HP:0003021)1.88565457
164Turricephaly (HP:0000262)1.88280042
165IgG deficiency (HP:0004315)1.87474309
166Neonatal onset (HP:0003623)1.87237658
167Abnormality of the pleura (HP:0002103)1.87195452
168J-shaped sella turcica (HP:0002680)1.85490087
169Irritability (HP:0000737)1.85311869
170Abnormality of the radial head (HP:0003995)1.85199199
171Epistaxis (HP:0000421)1.85116579
172Hemorrhage of the eye (HP:0011885)1.84718955
173Teleangiectasia of the skin (HP:0100585)1.84527891
174Opisthotonus (HP:0002179)1.83676219
175Stomach cancer (HP:0012126)1.83056602
176Hyperinsulinemic hypoglycemia (HP:0000825)1.82642653
177Sepsis (HP:0100806)1.82349067
178Biconcave vertebral bodies (HP:0004586)1.82302507
179Arterial thrombosis (HP:0004420)1.81871564
180Cervical subluxation (HP:0003308)1.81754068
181Recurrent sinusitis (HP:0011108)1.81713270
182Interstitial pulmonary disease (HP:0006530)1.80917402
183Lethargy (HP:0001254)1.80424182
184Increased mean platelet volume (HP:0011877)1.78816851
185Skin ulcer (HP:0200042)1.78523278
186Episodic fever (HP:0001954)1.78260763
187Autoimmune hemolytic anemia (HP:0001890)1.78194684
188Impaired platelet aggregation (HP:0003540)1.77630960
189Abnormal platelet function (HP:0011869)1.77630960
190Malnutrition (HP:0004395)1.77423469
191Increased serum ferritin (HP:0003281)1.77144011
192Mesangial abnormality (HP:0001966)1.73734909
193Stroke (HP:0001297)1.73645312
194Back pain (HP:0003418)1.72114904
195Abnormal platelet volume (HP:0011876)1.70135872
196Abnormality of alkaline phosphatase activity (HP:0004379)1.69502823
197Elevated hepatic transaminases (HP:0002910)1.69178248

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.96945541
2BCKDK4.38339040
3TRIB33.44571671
4SIK13.41927152
5PRPF4B3.28837014
6FGFR43.28322013
7FLT33.09009626
8SIK32.74783255
9RIPK42.65611586
10PKN22.61282749
11TNK22.25657212
12MAP3K102.11563566
13SIK22.06240026
14IRAK42.04479634
15TYK21.94294285
16MAP4K11.80792516
17SMG11.76531602
18EEF2K1.72184781
19PTK61.66256203
20MAPK111.64205611
21KIT1.59934657
22FES1.58314715
23TGFBR21.58232668
24JAK31.57414987
25BLK1.53662944
26TBK11.50143816
27MARK21.49287769
28TAOK31.46293363
29LRRK21.41031738
30HCK1.40688534
31PIK3CG1.38488756
32MAP2K31.36438479
33CAMKK11.30891452
34NME21.28662616
35ZAP701.22022883
36CAMK1D1.20133352
37MARK31.19909939
38PDGFRA1.16741075
39CDC42BPA1.16144414
40LCK1.15237904
41BTK1.14590108
42MAPK151.14460560
43STK101.13992061
44MAP3K71.13727003
45MAP3K31.13070124
46KDR1.13021224
47HIPK21.10389483
48GRK61.10010492
49CSF1R1.09768065
50RIPK11.08828972
51MAP3K11.08101582
52TGFBR11.07021799
53IRAK11.06915729
54EPHA31.06415188
55SYK1.03541225
56MAP3K141.03383099
57JAK11.02921949
58PRKD21.00945638
59RPS6KA40.99129495
60CDK60.98912746
61INSRR0.97186458
62TAOK10.96246519
63PIM20.95236898
64LATS10.93666594
65MAPK70.92380166
66BRD40.88785490
67PASK0.87622414
68NEK90.86525532
69DYRK1B0.86479054
70MAPK120.85564252
71TTN0.85336499
72MST1R0.85331628
73IKBKB0.85135480
74CDK40.84905430
75JAK20.84802798
76CDK120.84035293
77EPHB10.83227178
78FGFR30.82904839
79IKBKE0.81879908
80CHUK0.78790782
81TAOK20.77478319
82MAP3K60.77114288
83IRAK20.76916520
84TYRO30.72544669
85CSK0.72498187
86PIM10.72157668
87ICK0.70093411
88EPHB20.68479037
89PAK40.67944035
90CAMKK20.65688312
91BMX0.65528845
92LMTK20.64865554
93PDK10.64399162
94TEC0.64197069
95MTOR0.63348942
96MATK0.62946407
97MAP3K110.62771279
98PTK20.62139031
99KSR20.61549091
100NLK0.61279014
101PRKAA20.60715378
102RET0.57850797
103MAP2K20.57651087
104TIE10.56868938
105RPS6KC10.56715590
106RPS6KL10.56715590
107ITK0.56312763
108MAP2K60.56264921
109PAK20.56221481
110MAPK40.54556214
111FGR0.54073771
112IRAK30.53954522
113RPS6KB20.53593128
114PDGFRB0.52758231
115STK30.51027094
116FGFR20.50167116
117MAP3K80.48175715
118PDPK10.47264275
119MELK0.47001725
120SCYL20.46986397
121MAPKAPK30.46962036
122TXK0.46335607
123DDR20.46286200
124RPS6KA60.45668933
125ACVR1B0.45358878
126CDK70.44338531
127PRKG20.42958260
128CAMK40.42245113
129MET0.41851181
130GSK3A0.41349468
131FYN0.41186235
132YES10.41120427
133SGK30.40332975
134DYRK30.39607291
135CAMK1G0.39416742
136ERBB20.39087279
137ABL20.38929771
138PRKCQ0.38617417
139LYN0.37954057
140BRSK10.37875019
141STK380.37785394
142FGFR10.36608753
143IGF1R0.36036831
144MAP3K130.35517306
145ERBB40.35394580
146PRKCH0.32430315

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.93511252
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.32922848
3Nitrogen metabolism_Homo sapiens_hsa009103.22331459
4Primary immunodeficiency_Homo sapiens_hsa053402.85100696
5Fatty acid degradation_Homo sapiens_hsa000712.75405684
6Tryptophan metabolism_Homo sapiens_hsa003802.57252601
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.49122042
8Osteoclast differentiation_Homo sapiens_hsa043802.47990077
9Complement and coagulation cascades_Homo sapiens_hsa046102.46485257
10Arginine biosynthesis_Homo sapiens_hsa002202.42232287
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.41666061
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.41045794
13T cell receptor signaling pathway_Homo sapiens_hsa046602.40278055
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34536717
15B cell receptor signaling pathway_Homo sapiens_hsa046622.33199265
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.29776425
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.28928033
18Allograft rejection_Homo sapiens_hsa053302.10825048
19Graft-versus-host disease_Homo sapiens_hsa053322.07630026
20Peroxisome_Homo sapiens_hsa041462.03298849
21Autoimmune thyroid disease_Homo sapiens_hsa053202.03051504
22Caffeine metabolism_Homo sapiens_hsa002322.02916905
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.02834113
24PPAR signaling pathway_Homo sapiens_hsa033201.99397632
25Fatty acid metabolism_Homo sapiens_hsa012121.93396151
26Other glycan degradation_Homo sapiens_hsa005111.92592207
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.85868656
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.85738893
29Propanoate metabolism_Homo sapiens_hsa006401.84121683
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.82109456
31Selenocompound metabolism_Homo sapiens_hsa004501.77240224
32Staphylococcus aureus infection_Homo sapiens_hsa051501.75811609
33Chemical carcinogenesis_Homo sapiens_hsa052041.75424961
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.69305444
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.69029111
36Butanoate metabolism_Homo sapiens_hsa006501.68140944
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.65544679
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62918852
39Histidine metabolism_Homo sapiens_hsa003401.60384288
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.57896292
41Folate biosynthesis_Homo sapiens_hsa007901.56722524
42beta-Alanine metabolism_Homo sapiens_hsa004101.55233375
43Non-small cell lung cancer_Homo sapiens_hsa052231.53414548
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.51799914
45Retinol metabolism_Homo sapiens_hsa008301.49343829
46TNF signaling pathway_Homo sapiens_hsa046681.46660724
47Chronic myeloid leukemia_Homo sapiens_hsa052201.42286093
48Type I diabetes mellitus_Homo sapiens_hsa049401.42270849
49Hematopoietic cell lineage_Homo sapiens_hsa046401.40977910
50VEGF signaling pathway_Homo sapiens_hsa043701.40972855
51Jak-STAT signaling pathway_Homo sapiens_hsa046301.40443209
52Influenza A_Homo sapiens_hsa051641.40205421
53Toxoplasmosis_Homo sapiens_hsa051451.38453617
54Chemokine signaling pathway_Homo sapiens_hsa040621.37862721
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.37114749
56Bile secretion_Homo sapiens_hsa049761.35400389
57Intestinal immune network for IgA production_Homo sapiens_hsa046721.34862556
58Starch and sucrose metabolism_Homo sapiens_hsa005001.34615391
59Hepatitis B_Homo sapiens_hsa051611.33811807
60Tuberculosis_Homo sapiens_hsa051521.31098926
61One carbon pool by folate_Homo sapiens_hsa006701.30379402
62Maturity onset diabetes of the young_Homo sapiens_hsa049501.29996356
63Viral myocarditis_Homo sapiens_hsa054161.28792352
64Biosynthesis of amino acids_Homo sapiens_hsa012301.25757382
65Sulfur metabolism_Homo sapiens_hsa009201.25603332
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25090277
67Pyruvate metabolism_Homo sapiens_hsa006201.22154105
68Pancreatic cancer_Homo sapiens_hsa052121.22067873
69Sulfur relay system_Homo sapiens_hsa041221.21874664
70Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19369135
71Phenylalanine metabolism_Homo sapiens_hsa003601.19077174
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18236548
73Leukocyte transendothelial migration_Homo sapiens_hsa046701.16300367
74Carbon metabolism_Homo sapiens_hsa012001.15102568
75Lysine degradation_Homo sapiens_hsa003101.13363477
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13061262
77Choline metabolism in cancer_Homo sapiens_hsa052311.12904974
78Fat digestion and absorption_Homo sapiens_hsa049751.12614891
79Renal cell carcinoma_Homo sapiens_hsa052111.12539411
80Endometrial cancer_Homo sapiens_hsa052131.12243032
81Colorectal cancer_Homo sapiens_hsa052101.11616084
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11127424
83ABC transporters_Homo sapiens_hsa020101.10851813
84Prolactin signaling pathway_Homo sapiens_hsa049171.09081328
85Tyrosine metabolism_Homo sapiens_hsa003501.08020600
86Neurotrophin signaling pathway_Homo sapiens_hsa047221.05795650
87Cysteine and methionine metabolism_Homo sapiens_hsa002701.04944001
88mTOR signaling pathway_Homo sapiens_hsa041501.03673750
89Phospholipase D signaling pathway_Homo sapiens_hsa040721.01471945
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.99872571
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99635009
92Arginine and proline metabolism_Homo sapiens_hsa003300.99521930
93Platelet activation_Homo sapiens_hsa046110.99489344
94Inositol phosphate metabolism_Homo sapiens_hsa005620.98148979
95HTLV-I infection_Homo sapiens_hsa051660.97807642
96Epstein-Barr virus infection_Homo sapiens_hsa051690.96069221
97FoxO signaling pathway_Homo sapiens_hsa040680.95720554
98Apoptosis_Homo sapiens_hsa042100.92724941
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88662945
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88599155
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88587773
102Vitamin digestion and absorption_Homo sapiens_hsa049770.88358738
103Steroid biosynthesis_Homo sapiens_hsa001000.87557343
104Viral carcinogenesis_Homo sapiens_hsa052030.86563121
105Fatty acid biosynthesis_Homo sapiens_hsa000610.83940474
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83462245
107Asthma_Homo sapiens_hsa053100.80407608
108Prostate cancer_Homo sapiens_hsa052150.79610173
109Pentose phosphate pathway_Homo sapiens_hsa000300.79227087
110GnRH signaling pathway_Homo sapiens_hsa049120.78303499
111Fatty acid elongation_Homo sapiens_hsa000620.77645430
112ErbB signaling pathway_Homo sapiens_hsa040120.75704945
113Glutathione metabolism_Homo sapiens_hsa004800.74903663
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74501143
115MAPK signaling pathway_Homo sapiens_hsa040100.74253606
116Pertussis_Homo sapiens_hsa051330.73232738
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.73037338
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72923878
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66498248
120Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65581121
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65401715
122Endocytosis_Homo sapiens_hsa041440.65016573
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.62586344
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62392788
125Insulin signaling pathway_Homo sapiens_hsa049100.61899753
126Glycerolipid metabolism_Homo sapiens_hsa005610.61852800
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60760231
128Dorso-ventral axis formation_Homo sapiens_hsa043200.60238902
129Shigellosis_Homo sapiens_hsa051310.60139749
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58944077
131HIF-1 signaling pathway_Homo sapiens_hsa040660.58227834
132African trypanosomiasis_Homo sapiens_hsa051430.58072988
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56613545
134Galactose metabolism_Homo sapiens_hsa000520.55603658
135Glioma_Homo sapiens_hsa052140.54783570
136Type II diabetes mellitus_Homo sapiens_hsa049300.53626485
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.52497237
138Insulin resistance_Homo sapiens_hsa049310.52080619
139Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47574251
140Ras signaling pathway_Homo sapiens_hsa040140.46925793
141Regulation of autophagy_Homo sapiens_hsa041400.46259248
142Long-term potentiation_Homo sapiens_hsa047200.45571184
143Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43480398
144Estrogen signaling pathway_Homo sapiens_hsa049150.41381607
145Rap1 signaling pathway_Homo sapiens_hsa040150.41216367
146Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41213201
147Rheumatoid arthritis_Homo sapiens_hsa053230.41201001
148Amoebiasis_Homo sapiens_hsa051460.39823934
149Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37313323
150Fructose and mannose metabolism_Homo sapiens_hsa000510.32162863
151Metabolic pathways_Homo sapiens_hsa011000.31941481
152Legionellosis_Homo sapiens_hsa051340.31528318
153Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28547159
154Glycosaminoglycan degradation_Homo sapiens_hsa005310.27644554
155Prion diseases_Homo sapiens_hsa050200.24752727
156Notch signaling pathway_Homo sapiens_hsa043300.24320872
157Protein digestion and absorption_Homo sapiens_hsa049740.19525623
158Bladder cancer_Homo sapiens_hsa052190.18556009
159NF-kappa B signaling pathway_Homo sapiens_hsa040640.18493662
160Leishmaniasis_Homo sapiens_hsa051400.16362690
161Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15315194
162RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.15196707
163Malaria_Homo sapiens_hsa051440.14226245
164DNA replication_Homo sapiens_hsa030300.11903358
165Renin-angiotensin system_Homo sapiens_hsa046140.10878801
166AMPK signaling pathway_Homo sapiens_hsa041520.10311314
167Small cell lung cancer_Homo sapiens_hsa052220.10305162
168Thyroid cancer_Homo sapiens_hsa052160.09607924
169Base excision repair_Homo sapiens_hsa034100.09283664
170Herpes simplex infection_Homo sapiens_hsa051680.09144224
171Central carbon metabolism in cancer_Homo sapiens_hsa052300.08881943
172Acute myeloid leukemia_Homo sapiens_hsa052210.08711058
173Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.08491755
174Vitamin B6 metabolism_Homo sapiens_hsa007500.08072605
175alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.08015670
176Toll-like receptor signaling pathway_Homo sapiens_hsa046200.05986237
177Hepatitis C_Homo sapiens_hsa051600.05450080
178Measles_Homo sapiens_hsa051620.04374579
179Antigen processing and presentation_Homo sapiens_hsa046120.03638621
180ECM-receptor interaction_Homo sapiens_hsa045120.03163307

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