ATG9B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene functions in the regulation of autophagy, a lysosomal degradation pathway. This gene also functions as an antisense transcript in the posttranscriptional regulation of the endothelial nitric oxide synthase 3 gene, which has 3' overlap with this gene on the opposite strand. Mutations in this gene and disruption of the autophagy process have been associated with multiple cancers. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)9.68345224
2cilium movement (GO:0003341)9.11781936
3motile cilium assembly (GO:0044458)8.79181886
4desmosome organization (GO:0002934)8.78706304
5establishment of skin barrier (GO:0061436)8.72360856
6regulation of water loss via skin (GO:0033561)8.48419342
7epithelial cilium movement (GO:0003351)8.31714018
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.58047392
9axoneme assembly (GO:0035082)6.41872757
10intermediate filament organization (GO:0045109)6.12006991
11peptide cross-linking (GO:0018149)6.10514620
12skin morphogenesis (GO:0043589)6.04123864
13keratinocyte differentiation (GO:0030216)5.92602911
14piRNA metabolic process (GO:0034587)5.56620511
15negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.55672490
16multicellular organismal water homeostasis (GO:0050891)5.27523441
17bundle of His cell to Purkinje myocyte communication (GO:0086069)5.15009751
18interferon-gamma secretion (GO:0072643)4.97096594
19virion attachment to host cell (GO:0019062)4.92274210
20adhesion of symbiont to host cell (GO:0044650)4.92274210
21keratinocyte proliferation (GO:0043616)4.74673517
22regulation of cilium movement (GO:0003352)4.74049562
23ventricular system development (GO:0021591)4.69151212
24epidermal cell differentiation (GO:0009913)4.54117817
25spermatid development (GO:0007286)4.52107122
26seminiferous tubule development (GO:0072520)4.51688728
27epidermis development (GO:0008544)4.45456468
28cell-substrate junction assembly (GO:0007044)4.40452311
29exocrine pancreas development (GO:0031017)4.28544806
30viral transcription (GO:0019083)4.19657820
31water homeostasis (GO:0030104)4.09286688
32tolerance induction (GO:0002507)4.07877904
33left/right pattern formation (GO:0060972)4.05329554
34sperm motility (GO:0030317)4.02861182
35translational termination (GO:0006415)4.02441454
36male meiosis I (GO:0007141)3.98975054
37adhesion of symbiont to host (GO:0044406)3.93833208
38apoptotic process involved in morphogenesis (GO:0060561)3.88444073
39phosphatidylinositol acyl-chain remodeling (GO:0036149)3.88070367
40protein polyglutamylation (GO:0018095)3.72982531
41left/right axis specification (GO:0070986)3.69362525
42mitochondrion degradation (GO:0000422)3.69009381
43microtubule bundle formation (GO:0001578)3.60911171
44regulation of cardioblast differentiation (GO:0051890)3.58306624
45one-carbon compound transport (GO:0019755)3.57255705
46negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.55167670
47intermediate filament cytoskeleton organization (GO:0045104)3.54829332
48regulation of interleukin-5 production (GO:0032674)3.53904767
49IMP biosynthetic process (GO:0006188)3.53878069
50formation of translation preinitiation complex (GO:0001731)3.53713599
51translational elongation (GO:0006414)3.53553073
52citrulline biosynthetic process (GO:0019240)3.53515820
53phosphatidylserine acyl-chain remodeling (GO:0036150)3.51893770
54glial cell proliferation (GO:0014009)3.47080627
55phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.44936267
56hepatocyte apoptotic process (GO:0097284)3.44225777
57IMP metabolic process (GO:0046040)3.42146868
58intermediate filament-based process (GO:0045103)3.42118258
59ribosomal small subunit biogenesis (GO:0042274)3.41756306
60positive regulation of odontogenesis (GO:0042482)3.40196871
61excretion (GO:0007588)3.39463633
62cytoskeletal anchoring at plasma membrane (GO:0007016)3.38950717
63nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.36378431
64translational initiation (GO:0006413)3.35474431
65GDP-mannose metabolic process (GO:0019673)3.33409250
66mesodermal cell differentiation (GO:0048333)3.31047255
67hair follicle morphogenesis (GO:0031069)3.30893396
68vitamin transmembrane transport (GO:0035461)3.30871071
69epithelial cell-cell adhesion (GO:0090136)3.28364727
70regulation of transforming growth factor beta2 production (GO:0032909)3.26481963
71regulation of microtubule-based movement (GO:0060632)3.22833896
72atrioventricular valve morphogenesis (GO:0003181)3.22292140
73phosphatidylethanolamine biosynthetic process (GO:0006646)3.21902107
74SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.21244087
75negative regulation of cell fate specification (GO:0009996)3.20125966
76viral life cycle (GO:0019058)3.20113672
77cellular protein complex disassembly (GO:0043624)3.19965482
78ectoderm development (GO:0007398)3.18497626
79protein targeting to ER (GO:0045047)3.18431284
80meiosis I (GO:0007127)3.18165849
81positive regulation of protein kinase C signaling (GO:0090037)3.17754945
82cilium organization (GO:0044782)3.14938762
83negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.14869229
84cotranslational protein targeting to membrane (GO:0006613)3.14512364
85ribosomal large subunit biogenesis (GO:0042273)3.13593360
86intraciliary transport (GO:0042073)3.13148808
87embryonic camera-type eye development (GO:0031076)3.11519899
88ribosomal small subunit assembly (GO:0000028)3.07891341
89multicellular organism reproduction (GO:0032504)3.07737444
90establishment of protein localization to endoplasmic reticulum (GO:0072599)3.06116885
91protein localization to cilium (GO:0061512)3.04692654
92cilium assembly (GO:0042384)3.01526018
93positive regulation of hair follicle development (GO:0051798)3.00359615
94positive regulation of hair cycle (GO:0042635)3.00359615
95regulation of protein heterodimerization activity (GO:0043497)2.99412692
96peptidyl-arginine modification (GO:0018195)2.99317741
97centriole assembly (GO:0098534)2.99048362
98base-excision repair, AP site formation (GO:0006285)2.98990803
99fusion of sperm to egg plasma membrane (GO:0007342)2.98200293
100histone H3-K9 demethylation (GO:0033169)2.97928431
101response to xenobiotic stimulus (GO:0009410)2.97861174
102positive regulation of guanylate cyclase activity (GO:0031284)2.96906301
103apoptotic process involved in development (GO:1902742)2.96522280
104acrosome reaction (GO:0007340)2.95433482
105establishment of apical/basal cell polarity (GO:0035089)2.95219370
106hypotonic response (GO:0006971)2.92227408
107skin development (GO:0043588)2.91099404
108maternal placenta development (GO:0001893)2.90270518
109diterpenoid biosynthetic process (GO:0016102)2.85640104
110protein localization to endoplasmic reticulum (GO:0070972)2.85587934
111regulation of hair follicle development (GO:0051797)2.85461645
112pyrimidine-containing compound transmembrane transport (GO:0072531)2.84724730
113pentose-phosphate shunt (GO:0006098)2.83699603
114protein complex disassembly (GO:0043241)2.82912951
115phosphatidylethanolamine metabolic process (GO:0046337)2.81541244
116* autophagic vacuole assembly (GO:0000045)2.81467769
117rRNA catabolic process (GO:0016075)2.79221725
118L-fucose catabolic process (GO:0042355)2.79193001
119fucose catabolic process (GO:0019317)2.79193001
120L-fucose metabolic process (GO:0042354)2.79193001
121regulation of interleukin-13 production (GO:0032656)2.78314700
122lung epithelium development (GO:0060428)2.78272398
123regulation of glycogen (starch) synthase activity (GO:2000465)2.78207105
124transferrin transport (GO:0033572)2.78023657
125reproduction (GO:0000003)2.76858549
126decidualization (GO:0046697)2.75507473
127cornea development in camera-type eye (GO:0061303)2.74411208
128regulation of retinoic acid receptor signaling pathway (GO:0048385)2.73572884
129maturation of SSU-rRNA (GO:0030490)2.71733976
130nucleoside diphosphate phosphorylation (GO:0006165)2.71108485
131ethanol metabolic process (GO:0006067)2.70993405
132folic acid-containing compound biosynthetic process (GO:0009396)2.70386066
133renal filtration (GO:0097205)2.69833723
134apical protein localization (GO:0045176)2.68847927
135primary alcohol catabolic process (GO:0034310)2.68708356
136sperm capacitation (GO:0048240)2.68306228
137phosphatidylcholine acyl-chain remodeling (GO:0036151)2.67100944
138branching involved in mammary gland duct morphogenesis (GO:0060444)2.65494596
139regulation of vacuole organization (GO:0044088)2.65326902
140trivalent inorganic cation transport (GO:0072512)2.64287062
141ferric iron transport (GO:0015682)2.64287062
142male meiosis (GO:0007140)2.64158844
143DNA unwinding involved in DNA replication (GO:0006268)2.61742614
144positive regulation of epidermis development (GO:0045684)2.61581522
145negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.61058309
146establishment of monopolar cell polarity (GO:0061162)2.60470834
147establishment or maintenance of monopolar cell polarity (GO:0061339)2.60470834
148macromolecular complex disassembly (GO:0032984)2.59689320
149amyloid precursor protein catabolic process (GO:0042987)2.59314644
150positive regulation of tolerance induction (GO:0002645)2.59077045
151regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.57995140
152nuclear pore complex assembly (GO:0051292)2.54766782
153cell adhesion mediated by integrin (GO:0033627)2.53885210
154positive regulation of osteoblast proliferation (GO:0033690)2.50656476
155nodal signaling pathway (GO:0038092)2.48542738
156heterochromatin organization (GO:0070828)2.47130042
157cell wall macromolecule metabolic process (GO:0044036)2.45581806
158cell wall macromolecule catabolic process (GO:0016998)2.45581806
159regulation of transforming growth factor beta1 production (GO:0032908)2.44800247
160nucleobase biosynthetic process (GO:0046112)2.42973870
161regulation of secondary heart field cardioblast proliferation (GO:0003266)2.42372611
162regulation of cardioblast proliferation (GO:0003264)2.42372611
163regulation of hippo signaling (GO:0035330)2.41048929
164L-serine transport (GO:0015825)2.40938875
165adherens junction organization (GO:0034332)2.40918985
166receptor catabolic process (GO:0032801)2.40350914
167establishment of tissue polarity (GO:0007164)2.38347803
168establishment of planar polarity (GO:0001736)2.38347803
169keratinocyte development (GO:0003334)2.37732495
170phosphatidylserine metabolic process (GO:0006658)2.36483252
171morphogenesis of embryonic epithelium (GO:0016331)2.34635016
172molting cycle (GO:0042303)12.9040259
173hair cycle (GO:0042633)12.9040259
174axonemal dynein complex assembly (GO:0070286)11.3014217
175keratinization (GO:0031424)11.2258652
176cilium or flagellum-dependent cell motility (GO:0001539)10.3960483

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.85845110
2E2F7_22180533_ChIP-Seq_HELA_Human3.81767209
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.16598128
4VDR_22108803_ChIP-Seq_LS180_Human3.01145019
5ELF1_17652178_ChIP-ChIP_JURKAT_Human2.95866485
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.82656921
7ZNF263_19887448_ChIP-Seq_K562_Human2.79741756
8CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.59248149
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.56128681
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.47628082
11SMAD2/3_21741376_ChIP-Seq_ESCs_Human2.44331099
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.43301611
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.40523295
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.39246449
15P63_26484246_Chip-Seq_KERATINOCYTES_Human2.38825696
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.34934300
17SMC4_20622854_ChIP-Seq_HELA_Human2.30569726
18AR_21572438_ChIP-Seq_LNCaP_Human2.19502481
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.16599988
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02604181
21CTCF_27219007_Chip-Seq_Bcells_Human2.00579589
22TP63_17297297_ChIP-ChIP_HaCaT_Human12.6606399
23ATF3_27146783_Chip-Seq_COLON_Human1.99972223
24VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.98693349
25HIF1A_21447827_ChIP-Seq_MCF-7_Human1.97871667
26ESR1_15608294_ChIP-ChIP_MCF-7_Human1.93862765
27* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.91016528
28* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.91016528
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.87581148
30RACK7_27058665_Chip-Seq_MCF-7_Human1.85028438
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.77436347
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.77130024
33SCL_19346495_ChIP-Seq_HPC-7_Human1.72164684
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.69526305
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67195025
36OCT4_20526341_ChIP-Seq_ESCs_Human1.66093096
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.63365296
38DROSHA_22980978_ChIP-Seq_HELA_Human1.62405881
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.61748191
40ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.60342306
41RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.59679452
42LXR_22292898_ChIP-Seq_THP-1_Human1.54756453
43* RAC3_21632823_ChIP-Seq_H3396_Human1.54268783
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.53920029
45ERA_21632823_ChIP-Seq_H3396_Human1.53646231
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.51615454
47SA1_27219007_Chip-Seq_Bcells_Human1.47029447
48EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.47027398
49P300_27268052_Chip-Seq_Bcells_Human1.45577986
50NANOG_20526341_ChIP-Seq_ESCs_Human1.45305185
51HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.44428480
52FOXO3_23340844_ChIP-Seq_DLD1_Human1.44245243
53ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42908900
54MYC_22102868_ChIP-Seq_BL_Human1.42102414
55VDR_21846776_ChIP-Seq_THP-1_Human1.40869535
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.40832806
57ERG_20517297_ChIP-Seq_VCAP_Human1.40725621
58MYC_19829295_ChIP-Seq_ESCs_Human1.38067849
59* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37213210
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36922074
61P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.36210302
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35637286
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34706713
64UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34598857
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34560779
66EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.34492005
67AHR_22903824_ChIP-Seq_MCF-7_Human1.33001214
68FOXH1_21741376_ChIP-Seq_ESCs_Human1.32028847
69BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.31919068
70SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30347631
71ZNF274_21170338_ChIP-Seq_K562_Hela1.30254499
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29006440
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.27126923
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25453885
75RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.22588080
76FOXM1_23109430_ChIP-Seq_U2OS_Human1.22452460
77RUNX1_27514584_Chip-Seq_MCF-7_Human1.21953363
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21731400
79RAD21_21589869_ChIP-Seq_MESCs_Mouse1.20466909
80UBF1/2_26484160_Chip-Seq_HMECs_Human1.20214438
81TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.18959039
82XRN2_22483619_ChIP-Seq_HELA_Human1.17537066
83GATA6_25053715_ChIP-Seq_YYC3_Human1.17213276
84GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.17049850
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15042984
86TCF7_22412390_ChIP-Seq_EML_Mouse1.14569727
87HOXB7_26014856_ChIP-Seq_BT474_Human1.13442629
88CLOCK_20551151_ChIP-Seq_293T_Human1.12647567
89MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11605219
90GATA1_22025678_ChIP-Seq_K562_Human1.11463393
91GATA1_19941826_ChIP-Seq_K562_Human1.10110572
92CREB1_26743006_Chip-Seq_LNCaP_Human1.10008810
93CEBPB_22108803_ChIP-Seq_LS180_Human1.09913099
94GATA1_26923725_Chip-Seq_HPCs_Mouse1.09647835
95KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09346635
96PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09217774
97MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08724164
98CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08440608
99CTCF_21964334_Chip-Seq_Bcells_Human1.08399840
100* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07476296
101ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.06861787
102E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06766768
103KLF5_25053715_ChIP-Seq_YYC3_Human1.06030828
104P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05919494
105OCT4_19829295_ChIP-Seq_ESCs_Human1.05280940
106MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05007996
107RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04832894
108FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04656027
109FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04098269
110FOXA1_25329375_ChIP-Seq_VCAP_Human1.04098269
111AR_21909140_ChIP-Seq_LNCAP_Human1.04002380
112RUNX_20019798_ChIP-Seq_JUKART_Human1.03945725
113ELK1_22589737_ChIP-Seq_MCF10A_Human1.03945105
114SOX2_21211035_ChIP-Seq_LN229_Human1.03480388
115* TP53_20018659_ChIP-ChIP_R1E_Mouse1.03272772
116TP63_22573176_ChIP-Seq_HFKS_Human1.02996911
117BCOR_27268052_Chip-Seq_Bcells_Human1.02810085
118TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02753015
119GATA3_21878914_ChIP-Seq_MCF-7_Human1.02493064
120ELF1_20517297_ChIP-Seq_JURKAT_Human1.02216492
121E2F1_20622854_ChIP-Seq_HELA_Human1.01711128
122P53_21459846_ChIP-Seq_SAOS-2_Human1.01066157
123* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00931465
124ETV1_20927104_ChIP-Seq_GIST48_Human1.00768272
125TAF2_19829295_ChIP-Seq_ESCs_Human1.00675779
126* BCL6_27268052_Chip-Seq_Bcells_Human1.00098068
127SA1_27219007_Chip-Seq_ERYTHROID_Human0.98532666
128P68_20966046_ChIP-Seq_HELA_Human0.98394825
129NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98280891
130TP53_22127205_ChIP-Seq_IMR90_Human0.97523464
131OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97422364
132GATA4_25053715_ChIP-Seq_YYC3_Human0.96894829
133GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96829617
134NCOR_22424771_ChIP-Seq_293T_Human0.96622009
135WDR5_24793694_ChIP-Seq_LNCAP_Human0.96552537
136ELF5_23300383_ChIP-Seq_T47D_Human0.95905435
137ARNT_22903824_ChIP-Seq_MCF-7_Human0.95708130
138BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.95284583
139FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.94447018
140KLF4_19829295_ChIP-Seq_ESCs_Human0.94166199
141KDM2B_26808549_Chip-Seq_DND41_Human0.93921629
142YY1_22570637_ChIP-Seq_MALME-3M_Human0.93524382
143GATA6_21074721_ChIP-Seq_CACO-2_Human0.93006487
144RBPJ_21746931_ChIP-Seq_IB4_Human0.92858676
145MAF_26560356_Chip-Seq_TH2_Human0.92696501
146STAT1_20625510_ChIP-Seq_HELA_Human0.92005148
147SOX2_20726797_ChIP-Seq_SW620_Human0.91686740
148CTCF_21964334_ChIP-Seq_BJAB-B_Human0.91237344
149JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90732702
150CTCF_20526341_ChIP-Seq_ESCs_Human0.90435979
151FLI1_21867929_ChIP-Seq_CD8_Mouse0.90069561
152CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.89915359
153SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89263318
154CBP_20019798_ChIP-Seq_JUKART_Human0.89038792
155IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89038792
156* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.88474947
157NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87886034
158RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87488387
159EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.86459274
160CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86174225
161RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.85689641
162TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84786892
163CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83914268
164PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.83202768
165ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82614236
166SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82435052
167NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.81656875
168TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81433586
169TTF2_22483619_ChIP-Seq_HELA_Human0.81019325
170CHD1_26751641_Chip-Seq_LNCaP_Human0.80617200
171NANOG_18692474_ChIP-Seq_MEFs_Mouse0.80577844
172PHF8_20622854_ChIP-Seq_HELA_Human0.79700991
173FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.78802744
174KLF4_18555785_ChIP-Seq_MESCs_Mouse0.78465036
175* GATA3_24758297_ChIP-Seq_MCF-7_Human0.78440300
176DNAJC2_21179169_ChIP-ChIP_NT2_Human0.78415436

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology6.64539565
2MP0005377_hearing/vestibular/ear_phenot6.64539565
3MP0010234_abnormal_vibrissa_follicle6.43956681
4MP0002796_impaired_skin_barrier6.38705138
5MP0005275_abnormal_skin_tensile5.44637410
6MP0005501_abnormal_skin_physiology4.44028535
7MP0000579_abnormal_nail_morphology3.91381544
8MP0002254_reproductive_system_inflammat3.20734274
9MP0003705_abnormal_hypodermis_morpholog3.05470505
10MP0001216_abnormal_epidermal_layer3.00938416
11MP0010678_abnormal_skin_adnexa2.98272031
12MP0002098_abnormal_vibrissa_morphology2.96768362
13MP0002060_abnormal_skin_morphology2.84392357
14MP0010771_integument_phenotype2.72204832
15MP0003453_abnormal_keratinocyte_physiol2.70491525
16MP0000647_abnormal_sebaceous_gland2.55441788
17MP0000383_abnormal_hair_follicle2.54975925
18MP0004782_abnormal_surfactant_physiolog2.53048976
19MP0000537_abnormal_urethra_morphology2.42924862
20MP0003941_abnormal_skin_development2.34277997
21MP0004947_skin_inflammation2.32185051
22MP0000377_abnormal_hair_follicle2.31864120
23MP0002653_abnormal_ependyma_morphology2.28438207
24MP0005410_abnormal_fertilization2.24113418
25MP0003566_abnormal_cell_adhesion2.17808985
26MP0000467_abnormal_esophagus_morphology2.14592330
27MP0006054_spinal_hemorrhage2.08980545
28MP0001986_abnormal_taste_sensitivity1.99883635
29MP0001849_ear_inflammation1.99250318
30MP0008872_abnormal_physiological_respon1.98745682
31MP0010352_gastrointestinal_tract_polyps1.96987365
32MP0004043_abnormal_pH_regulation1.96577369
33MP0002132_abnormal_respiratory_system1.96433714
34MP0008995_early_reproductive_senescence1.94705455
35MP0000566_synostosis1.90614298
36MP0000678_abnormal_parathyroid_gland1.76284956
37MP0009697_abnormal_copulation1.73099353
38MP0004019_abnormal_vitamin_homeostasis1.73006544
39MP0001346_abnormal_lacrimal_gland1.72200556
40MP0002876_abnormal_thyroid_physiology1.70424157
41MP0000762_abnormal_tongue_morphology1.65768819
42MP0009931_abnormal_skin_appearance1.64197412
43MP0003698_abnormal_male_reproductive1.58526690
44MP0001765_abnormal_ion_homeostasis1.58386367
45MP0003329_amyloid_beta_deposits1.54819275
46MP0001905_abnormal_dopamine_level1.48896427
47MP0004264_abnormal_extraembryonic_tissu1.48303275
48MP0002234_abnormal_pharynx_morphology1.48088869
49MP0001929_abnormal_gametogenesis1.43849776
50MP0005023_abnormal_wound_healing1.43732096
51MP0000427_abnormal_hair_cycle1.41823225
52MP0004133_heterotaxia1.40277505
53MP0001984_abnormal_olfaction1.37680877
54MP0001191_abnormal_skin_condition1.32919800
55MP0005647_abnormal_sex_gland1.31321025
56MP0001348_abnormal_lacrimal_gland1.30764301
57MP0004272_abnormal_basement_membrane1.27293255
58MP0000627_abnormal_mammary_gland1.26505229
59MP0002210_abnormal_sex_determination1.26465102
60MP0001243_abnormal_dermal_layer1.26311941
61MP0003300_gastrointestinal_ulcer1.25489919
62MP0005076_abnormal_cell_differentiation1.23685979
63MP0000465_gastrointestinal_hemorrhage1.22622984
64MP0000858_altered_metastatic_potential1.22032426
65MP0004957_abnormal_blastocyst_morpholog1.21591332
66MP0008789_abnormal_olfactory_epithelium1.21377549
67MP0002160_abnormal_reproductive_system1.20404251
68MP0004885_abnormal_endolymph1.16803163
69MP0000367_abnormal_coat/_hair1.14935158
70MP0003718_maternal_effect1.13403176
71MP0009333_abnormal_splenocyte_physiolog1.07994332
72MP0005167_abnormal_blood-brain_barrier1.06837051
73MP0001873_stomach_inflammation1.06827589
74MP0008260_abnormal_autophagy1.06375082
75MP0000490_abnormal_crypts_of1.04805720
76MP0009379_abnormal_foot_pigmentation1.04026935
77MP0008875_abnormal_xenobiotic_pharmacok0.98936414
78MP0001145_abnormal_male_reproductive0.98680134
79MP0001485_abnormal_pinna_reflex0.98291794
80MP0005636_abnormal_mineral_homeostasis0.94954034
81MP0005394_taste/olfaction_phenotype0.92846452
82MP0005499_abnormal_olfactory_system0.92846452
83MP0005670_abnormal_white_adipose0.90660009
84MP0005310_abnormal_salivary_gland0.89499744
85MP0010307_abnormal_tumor_latency0.88724275
86MP0000653_abnormal_sex_gland0.87359338
87MP0000604_amyloidosis0.87289968
88MP0005646_abnormal_pituitary_gland0.87089121
89MP0005645_abnormal_hypothalamus_physiol0.84802456
90MP0004808_abnormal_hematopoietic_stem0.83639678
91MP0003567_abnormal_fetal_cardiomyocyte0.81650688
92MP0004185_abnormal_adipocyte_glucose0.81245789
93MP0002277_abnormal_respiratory_mucosa0.81076295
94MP0002089_abnormal_postnatal_growth/wei0.80434475
95MP0000477_abnormal_intestine_morphology0.80150168
96MP0003191_abnormal_cellular_cholesterol0.80094569
97MP0005253_abnormal_eye_physiology0.79944552
98MP0003638_abnormal_response/metabolism_0.79460487
99MP0005423_abnormal_somatic_nervous0.78975308
100MP0004381_abnormal_hair_follicle0.78172019
101MP0001881_abnormal_mammary_gland0.78151682
102MP0003436_decreased_susceptibility_to0.77843039
103MP0003115_abnormal_respiratory_system0.77520620
104MP0002877_abnormal_melanocyte_morpholog0.76686237
105MP0006035_abnormal_mitochondrial_morpho0.75998768
106MP0002161_abnormal_fertility/fecundity0.75889293
107MP0002638_abnormal_pupillary_reflex0.75462943
108MP0006072_abnormal_retinal_apoptosis0.75265218
109MP0003866_abnormal_defecation0.75198050
110MP0001784_abnormal_fluid_regulation0.74708788
111MP0003448_altered_tumor_morphology0.73641013
112MP0001545_abnormal_hematopoietic_system0.73085682
113MP0005397_hematopoietic_system_phenotyp0.73085682
114MP0006036_abnormal_mitochondrial_physio0.73052155
115MP0010155_abnormal_intestine_physiology0.72960808
116MP0005671_abnormal_response_to0.72555736
117MP0003879_abnormal_hair_cell0.72519657
118MP0004197_abnormal_fetal_growth/weight/0.71361308
119MP0000681_abnormal_thyroid_gland0.70231240
120MP0006292_abnormal_olfactory_placode0.69863797
121MP0001293_anophthalmia0.68174255
122MP0003763_abnormal_thymus_physiology0.67578870
123MP0001730_embryonic_growth_arrest0.67201225
124MP0001664_abnormal_digestion0.66493769
125MP0005389_reproductive_system_phenotype0.66298954
126MP0003111_abnormal_nucleus_morphology0.66135764
127MP0002127_abnormal_cardiovascular_syste0.65403868
128MP0000350_abnormal_cell_proliferation0.65127248
129MP0009053_abnormal_anal_canal0.64025111
130MP0002396_abnormal_hematopoietic_system0.59489941
131MP0000733_abnormal_muscle_development0.56737700
132MP0002282_abnormal_trachea_morphology0.55936057
133MP0000750_abnormal_muscle_regeneration0.55229440
134MP0002148_abnormal_hypersensitivity_rea0.55213071
135MP0002111_abnormal_tail_morphology0.55188834
136MP0001502_abnormal_circadian_rhythm0.55083719
137MP0000026_abnormal_inner_ear0.54583121
138MP0003123_paternal_imprinting0.53253261
139MP0002019_abnormal_tumor_incidence0.53078537
140MP0001188_hyperpigmentation0.52579045
141MP0004742_abnormal_vestibular_system0.52306054
142MP0008932_abnormal_embryonic_tissue0.51843517
143MP0008770_decreased_survivor_rate0.50900908
144MP0001968_abnormal_touch/_nociception0.50300620
145MP0000470_abnormal_stomach_morphology0.49778594
146MP0002084_abnormal_developmental_patter0.49485220
147MP0008438_abnormal_cutaneous_collagen0.47970064
148MP0001879_abnormal_lymphatic_vessel0.47484996
149MP0000538_abnormal_urinary_bladder0.46906619
150MP0001286_abnormal_eye_development0.46777070
151MP0005174_abnormal_tail_pigmentation0.46736999
152MP0002006_tumorigenesis0.46277980
153MP0000751_myopathy0.45949516
154MP0009643_abnormal_urine_homeostasis0.45680212
155MP0002086_abnormal_extraembryonic_tissu0.45004044
156MP0001851_eye_inflammation0.44873840
157MP0005391_vision/eye_phenotype0.44567541
158MP0005551_abnormal_eye_electrophysiolog0.44337617
159MP0003693_abnormal_embryo_hatching0.44098749
160MP0002136_abnormal_kidney_physiology0.43210265
161MP0005193_abnormal_anterior_eye0.43064620
162MP0002080_prenatal_lethality0.42876356
163MP0008007_abnormal_cellular_replicative0.42130270
164MP0002166_altered_tumor_susceptibility0.41789058
165MP0003303_peritoneal_inflammation0.41531447
166MP0005165_increased_susceptibility_to0.41266645
167MP0008004_abnormal_stomach_pH0.41181131
168MP0003755_abnormal_palate_morphology0.40657430
169MP0002177_abnormal_outer_ear0.40639691
170MP0003119_abnormal_digestive_system0.39758126

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.85826973
2Onycholysis (HP:0001806)7.69216893
3Abnormal respiratory motile cilium physiology (HP:0012261)7.09751294
4Abnormal ciliary motility (HP:0012262)7.01502027
5Dynein arm defect of respiratory motile cilia (HP:0012255)7.01234517
6Absent/shortened dynein arms (HP:0200106)7.01234517
7Abnormal respiratory epithelium morphology (HP:0012253)6.99256692
8Abnormal respiratory motile cilium morphology (HP:0005938)6.99256692
9Hypotrichosis (HP:0001006)6.55043473
10Fragile nails (HP:0001808)6.32779207
11Plantar hyperkeratosis (HP:0007556)6.29395149
12Rhinitis (HP:0012384)6.20938508
13Woolly hair (HP:0002224)6.16589481
14Milia (HP:0001056)6.07317725
15Increased IgE level (HP:0003212)5.66390451
16Abnormality of nail color (HP:0100643)5.62464270
17Pili torti (HP:0003777)5.59766718
18Nail dystrophy (HP:0008404)5.45368375
19Palmoplantar hyperkeratosis (HP:0000972)5.23312097
20Right ventricular cardiomyopathy (HP:0011663)5.09351614
21Chronic bronchitis (HP:0004469)5.07898069
22Palmar hyperkeratosis (HP:0010765)4.89511407
23Increased circulating renin level (HP:0000848)4.82728151
24Atrophic scars (HP:0001075)4.61191377
25Bronchiectasis (HP:0002110)4.58742184
26Nasal polyposis (HP:0100582)4.20253583
27Abnormal blistering of the skin (HP:0008066)4.00250435
28Congenital ichthyosiform erythroderma (HP:0007431)3.79895057
29Tetany (HP:0001281)3.71373723
30Thick nail (HP:0001805)3.70252947
31Hypokalemic alkalosis (HP:0001949)3.67725280
32Erythema (HP:0010783)3.67261695
33Alopecia of scalp (HP:0002293)3.61571352
34Conjunctival hamartoma (HP:0100780)3.60276563
35Oral leukoplakia (HP:0002745)3.56545146
36Infertility (HP:0000789)3.49101926
37Abnormality of dental color (HP:0011073)3.44438039
38Ridged nail (HP:0001807)3.39530060
39Abnormal hair laboratory examination (HP:0003328)3.35187862
40Abnormal drinking behavior (HP:0030082)3.34479208
41Polydipsia (HP:0001959)3.34479208
42Bilateral sensorineural hearing impairment (HP:0008619)3.31680668
43Abnormality of the nasal mucosa (HP:0000433)3.28276147
44Fragile skin (HP:0001030)3.21810265
45Abnormality of renin-angiotensin system (HP:0000847)3.15887776
46Curly hair (HP:0002212)3.14114041
47Hypomagnesemia (HP:0002917)3.11884762
48Tubulointerstitial nephritis (HP:0001970)3.10211685
49Male infertility (HP:0003251)3.10034279
50Chronic hepatic failure (HP:0100626)3.09973287
51Molar tooth sign on MRI (HP:0002419)3.02786755
52Abnormality of midbrain morphology (HP:0002418)3.02786755
53Trismus (HP:0000211)2.92164124
54Asplenia (HP:0001746)2.89871011
55Erythroderma (HP:0001019)2.85108295
56Aplasia/Hypoplasia of the spleen (HP:0010451)2.81375305
57Follicular hyperkeratosis (HP:0007502)2.78197885
58Distal arthrogryposis (HP:0005684)2.70511813
59Abnormality of hair growth rate (HP:0011363)2.68449435
60Slow-growing hair (HP:0002217)2.68449435
61Abnormality of magnesium homeostasis (HP:0004921)2.61264276
62Abnormality of the gastric mucosa (HP:0004295)2.60954741
63Arterial tortuosity (HP:0005116)2.60794967
64Occipital encephalocele (HP:0002085)2.58573126
65Recurrent sinusitis (HP:0011108)2.57894851
66Paralysis (HP:0003470)2.56818147
67Recurrent otitis media (HP:0000403)2.56178620
68Bronchitis (HP:0012387)2.53997988
69Ventricular tachycardia (HP:0004756)2.51990919
70Ankyloglossia (HP:0010296)2.48864719
71Brittle hair (HP:0002299)2.45001474
72Abnormality of the neuromuscular junction (HP:0003398)2.41266901
73Fatigable weakness (HP:0003473)2.41266901
74Abnormality of oral frenula (HP:0000190)2.40936533
75Anonychia (HP:0001798)2.40597249
76Chronic sinusitis (HP:0011109)2.39029933
77Abnormality of permanent molar morphology (HP:0011071)2.38935776
78Abnormality of the dental root (HP:0006486)2.38935776
79Taurodontia (HP:0000679)2.38935776
80Corneal erosion (HP:0200020)2.37857960
81Abnormality of the dental pulp (HP:0006479)2.35482113
82Distal lower limb muscle weakness (HP:0009053)2.33494059
83Pancreatic fibrosis (HP:0100732)2.33021171
84Polyuria (HP:0000103)2.31123190
85Spondylolisthesis (HP:0003302)2.31018145
86Vascular tortuosity (HP:0004948)2.29509735
87True hermaphroditism (HP:0010459)2.28214264
88Palmoplantar keratoderma (HP:0000982)2.27753987
89Sparse eyelashes (HP:0000653)2.23649134
90Pustule (HP:0200039)2.23538887
91Abnormality of cells of the erythroid lineage (HP:0012130)2.21828126
92Cerebral aneurysm (HP:0004944)2.21670349
93Ectropion (HP:0000656)2.19859100
94Pancreatic cysts (HP:0001737)2.19535937
95Hamartoma of the eye (HP:0010568)2.18783791
96Abnormality of molar morphology (HP:0011070)2.17876826
97Abnormality of molar (HP:0011077)2.17876826
98Cone-rod dystrophy (HP:0000548)2.16342981
99Abnormality of the calcaneus (HP:0008364)2.14211670
100Nephronophthisis (HP:0000090)2.13119862
101Abnormality of the frontal sinuses (HP:0002687)2.12232702
102Interstitial pulmonary disease (HP:0006530)2.10074020
103Chronic otitis media (HP:0000389)2.08874168
104Renal tubular acidosis (HP:0001947)2.08619529
105Hyperactive renin-angiotensin system (HP:0000841)2.07330441
106Hypoplasia of dental enamel (HP:0006297)2.05443076
107Calcaneovalgus deformity (HP:0001848)2.05169979
108Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.02515362
109Clumsiness (HP:0002312)2.01873405
110Ulnar deviation of the wrist (HP:0003049)2.01261280
111Abnormal number of erythroid precursors (HP:0012131)1.97400512
112Absent rod-and cone-mediated responses on ERG (HP:0007688)1.97252425
113Hypohidrosis (HP:0000966)1.97036853
114Cystic liver disease (HP:0006706)1.93620883
115Lack of skin elasticity (HP:0100679)1.93274678
116Spastic diplegia (HP:0001264)1.93224499
117Lip pit (HP:0100267)1.92761667
118Hyporeflexia of lower limbs (HP:0002600)1.92743805
119Increased connective tissue (HP:0009025)1.91521551
120Gangrene (HP:0100758)1.91063459
121Amelogenesis imperfecta (HP:0000705)1.90811248
122Blepharitis (HP:0000498)1.90183682
123Biliary tract neoplasm (HP:0100574)1.86023418
124Hyperhidrosis (HP:0000975)1.85918777
125Sparse scalp hair (HP:0002209)1.85784798
126Neurodegeneration (HP:0002180)1.85398869
127Pterygium (HP:0001059)1.84771291
128Parakeratosis (HP:0001036)1.84482732
129Distal lower limb amyotrophy (HP:0008944)1.83707108
130Abnormality of placental membranes (HP:0011409)1.80466727
131Amniotic constriction ring (HP:0009775)1.80466727
132Abnormal urine output (HP:0012590)1.79822013
133Skin ulcer (HP:0200042)1.78439177
134Reticulocytopenia (HP:0001896)1.78186494
135Hypergammaglobulinemia (HP:0010702)1.78030681
136Abnormality of the renal medulla (HP:0100957)1.77928255
137Aplasia cutis congenita (HP:0001057)1.75571805
138Increased density of long bones (HP:0006392)1.75336011
139Furrowed tongue (HP:0000221)1.75164193
140Selective tooth agenesis (HP:0001592)1.75072981
141Alkalosis (HP:0001948)1.74814550
142Abnormality of renal excretion (HP:0011036)1.73428941
143Radial bowing (HP:0002986)1.72189655
144Hypokalemia (HP:0002900)1.71223838
145Ureteral stenosis (HP:0000071)1.70735237
146Deformed tarsal bones (HP:0008119)1.70124922
147Esophageal atresia (HP:0002032)1.69981468
148Achilles tendon contracture (HP:0001771)1.69328721
149High anterior hairline (HP:0009890)1.69303004
150Ankle contracture (HP:0006466)1.68310452
151Type 1 muscle fiber predominance (HP:0003803)1.67786817
152Hypoplasia of the uterus (HP:0000013)1.67467351
153Neck muscle weakness (HP:0000467)1.65692430
154Frequent falls (HP:0002359)1.64494123
155Carious teeth (HP:0000670)1.64412553
156Rectal prolapse (HP:0002035)1.63417571
157Advanced eruption of teeth (HP:0006288)1.62206288
158Spinal cord compression (HP:0002176)1.61785467
159Aortic dissection (HP:0002647)1.61403505
160Hyperkalemia (HP:0002153)1.61036028
161Micronodular cirrhosis (HP:0001413)1.59453119
162Hypercortisolism (HP:0001578)1.57649008
163Hyperparathyroidism (HP:0000843)1.56971426
164Round ear (HP:0100830)1.56285669
165Abnormality of potassium homeostasis (HP:0011042)1.55901705
166Anterior segment dysgenesis (HP:0007700)1.55536235
167Abnormality of the fingernails (HP:0001231)1.55324014
168Myopathic facies (HP:0002058)1.54242533
169Keratoconjunctivitis (HP:0001096)1.53607026
170Abnormal rod and cone electroretinograms (HP:0008323)1.53276936
171Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.52790597
172Male pseudohermaphroditism (HP:0000037)1.52761286
173Abnormality of secondary sexual hair (HP:0009888)1.52535627
174Abnormality of the axillary hair (HP:0100134)1.52535627
175Attenuation of retinal blood vessels (HP:0007843)1.51710407
176Elevated erythrocyte sedimentation rate (HP:0003565)1.49745301

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA28.18772096
2WNK47.55851319
3STK397.36519695
4OXSR15.44048608
5PINK14.33402601
6SCYL23.72412670
7MAP3K123.34150320
8RPS6KB22.95395782
9MAPK152.94620992
10FER2.90032902
11MST42.75958536
12PIM22.66298123
13EEF2K2.50140958
14MAPKAPK32.49617241
15TTN2.38505561
16PAK42.31598130
17LRRK22.05279861
18DAPK21.96711323
19MST1R1.77460405
20PKN21.77401877
21TAOK31.70628235
22NME11.70227470
23PLK41.58754375
24TRIB31.58340285
25PIK3CG1.58036138
26STK381.57378111
27TAOK11.53708120
28CDK121.51901841
29PTK2B1.51205349
30PTK61.47249979
31PTK21.45552221
32MAP3K111.44100438
33MAP3K91.38124315
34MAP3K31.33975376
35TRIM281.31761587
36EPHB21.28154357
37TXK1.25670037
38STK101.25028348
39ERN11.24944255
40MARK31.23809909
41STK38L1.21891174
42MAP2K71.19707268
43PBK1.19218291
44TESK21.12830338
45TNIK1.09448951
46ALK1.08690855
47MAP4K11.07169489
48TSSK61.07082086
49MAP3K61.06770568
50PAK21.03772469
51TNK21.03602211
52MAP2K31.02997761
53MAP2K21.01235299
54CDK60.95766820
55MAP2K60.93381481
56MAP3K80.90345685
57RPS6KC10.90058352
58RPS6KL10.90058352
59RPS6KA60.87521535
60LATS20.85085942
61TESK10.80488958
62MYLK0.80357583
63MUSK0.80325528
64MAP3K10.73757900
65EPHB10.71735622
66RPS6KA20.71608316
67MAP3K20.71267825
68DYRK1B0.69615167
69NEK20.69496114
70MAP2K10.68992904
71FGFR10.68076668
72NEK10.67746064
73MATK0.67440779
74BRD40.67349235
75DDR20.66825163
76BLK0.66277385
77BMX0.64127359
78SIK20.63294942
79MET0.63014643
80ILK0.61574945
81MAP3K70.60471934
82ROCK20.60115735
83NLK0.60101871
84SGK2230.59922140
85SGK4940.59922140
86DAPK30.57820179
87PRKCI0.57023420
88RIPK10.56457382
89FLT30.55843870
90LMTK20.54771194
91BCR0.54680493
92LIMK10.54060817
93TGFBR20.52018864
94AKT20.51902732
95KDR0.50866491
96MAP3K100.50654556
97PRKAA20.50050286
98MAPKAPK20.50008736
99FES0.49135247
100GRK60.48403711
101MAP3K40.47842729
102ITK0.47336596
103MAPK130.47129810
104IKBKB0.46912485
105TAOK20.46814502
106TBK10.46199626
107ZAP700.45678555
108PRKCQ0.45555646
109CDK190.44691568
110NEK60.44358564
111CSK0.44160278
112INSRR0.43865532
113MAP3K50.43615666
114CDK70.43141215
115PASK0.41708749
116JAK30.41341742
117WEE10.41217090
118DAPK10.40400909
119MARK20.39787115
120GRK10.39518947
121PHKG20.38457721
122PHKG10.38457721
123AURKA0.38065810
124MAPKAPK50.38037814
125LCK0.37812889
126AURKB0.37511116
127CSNK1G30.36962577
128PRKG20.36643934
129NME20.36345644
130CSNK1A1L0.35918667
131IKBKE0.34742309
132RPS6KB10.34265544
133PIM10.34102366
134PKN10.34067062
135BTK0.34015330
136EIF2AK30.33973564
137PAK10.33805405
138STK240.33784806
139PRKD20.32589355
140SRC0.32349357
141PDGFRA0.31307937
142MTOR0.30815269
143CSNK1E0.30436982
144TTK0.30179819
145CDK80.30121361
146PDK10.28900025
147PAK30.28758215
148SGK20.28118550
149ERBB30.27973813
150TGFBR10.27859092
151ADRBK10.27324620
152RPS6KA10.26590557
153TLK10.26573742
154TYRO30.26513064
155RPS6KA40.24738004
156KSR20.24701381
157MAP2K40.23670874
158LATS10.23099433
159SRPK10.22735807
160NTRK10.22470408
161FGFR20.20126452
162SGK10.19503665
163PLK20.18858944
164TIE10.17861401
165PDPK10.16720340

Predicted pathways (KEGG)

RankGene SetZ-score
1Collecting duct acid secretion_Homo sapiens_hsa049664.20098875
2Regulation of autophagy_Homo sapiens_hsa041403.41472165
3Ribosome_Homo sapiens_hsa030102.92927497
4Olfactory transduction_Homo sapiens_hsa047402.68404792
5Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.45490557
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.39416551
7p53 signaling pathway_Homo sapiens_hsa041152.38942735
8Bladder cancer_Homo sapiens_hsa052192.15727029
9Folate biosynthesis_Homo sapiens_hsa007902.14123597
10Small cell lung cancer_Homo sapiens_hsa052222.12597751
11Phenylalanine metabolism_Homo sapiens_hsa003602.07762046
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.03534464
13Thyroid cancer_Homo sapiens_hsa052162.02707370
14ECM-receptor interaction_Homo sapiens_hsa045122.00923765
15Ether lipid metabolism_Homo sapiens_hsa005651.97008812
16Phototransduction_Homo sapiens_hsa047441.95781098
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.90962778
18Hedgehog signaling pathway_Homo sapiens_hsa043401.89879485
19Synaptic vesicle cycle_Homo sapiens_hsa047211.89281554
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83989871
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.79253082
22Proteoglycans in cancer_Homo sapiens_hsa052051.71668733
23DNA replication_Homo sapiens_hsa030301.70333084
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.67000239
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.64334486
26Chronic myeloid leukemia_Homo sapiens_hsa052201.61497160
27Chemical carcinogenesis_Homo sapiens_hsa052041.58597968
28Primary immunodeficiency_Homo sapiens_hsa053401.55559810
29beta-Alanine metabolism_Homo sapiens_hsa004101.53642281
30Tight junction_Homo sapiens_hsa045301.53352048
31Histidine metabolism_Homo sapiens_hsa003401.50010595
32Adherens junction_Homo sapiens_hsa045201.49355034
33ABC transporters_Homo sapiens_hsa020101.47642589
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.46403171
35VEGF signaling pathway_Homo sapiens_hsa043701.43348708
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.42654899
37Colorectal cancer_Homo sapiens_hsa052101.40519966
38Amoebiasis_Homo sapiens_hsa051461.39686892
39Ovarian steroidogenesis_Homo sapiens_hsa049131.37150805
40Toxoplasmosis_Homo sapiens_hsa051451.33608423
41Hippo signaling pathway_Homo sapiens_hsa043901.32856478
42Focal adhesion_Homo sapiens_hsa045101.32694465
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.32469146
44Shigellosis_Homo sapiens_hsa051311.30994364
45Basal transcription factors_Homo sapiens_hsa030221.27684558
46Taste transduction_Homo sapiens_hsa047421.23934201
47Proteasome_Homo sapiens_hsa030501.22101803
48Huntingtons disease_Homo sapiens_hsa050161.20561002
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20496809
50MicroRNAs in cancer_Homo sapiens_hsa052061.16341233
51Peroxisome_Homo sapiens_hsa041461.16275715
52Sphingolipid metabolism_Homo sapiens_hsa006001.13158020
53Pancreatic cancer_Homo sapiens_hsa052121.11287457
54Notch signaling pathway_Homo sapiens_hsa043301.10607872
55Glioma_Homo sapiens_hsa052141.09454263
56RNA transport_Homo sapiens_hsa030131.06803478
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02943472
58Apoptosis_Homo sapiens_hsa042101.02583884
59Hematopoietic cell lineage_Homo sapiens_hsa046401.02187982
60GnRH signaling pathway_Homo sapiens_hsa049121.00781356
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.98907639
62Tyrosine metabolism_Homo sapiens_hsa003500.98872371
63Acute myeloid leukemia_Homo sapiens_hsa052210.98796603
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98169206
65HIF-1 signaling pathway_Homo sapiens_hsa040660.96845152
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96833371
67Salmonella infection_Homo sapiens_hsa051320.96729501
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.95959856
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.95259104
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95218624
71Cell cycle_Homo sapiens_hsa041100.94553839
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93080990
73RNA degradation_Homo sapiens_hsa030180.92777901
74HTLV-I infection_Homo sapiens_hsa051660.92685556
75Fructose and mannose metabolism_Homo sapiens_hsa000510.92211342
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.91944012
77Estrogen signaling pathway_Homo sapiens_hsa049150.89803624
78Spliceosome_Homo sapiens_hsa030400.89311709
79TGF-beta signaling pathway_Homo sapiens_hsa043500.88631060
80Glutathione metabolism_Homo sapiens_hsa004800.88567851
81Renal cell carcinoma_Homo sapiens_hsa052110.87795552
82Endometrial cancer_Homo sapiens_hsa052130.86255483
83Dilated cardiomyopathy_Homo sapiens_hsa054140.85970835
84Pathways in cancer_Homo sapiens_hsa052000.85253660
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83547927
86mRNA surveillance pathway_Homo sapiens_hsa030150.82857447
87Mismatch repair_Homo sapiens_hsa034300.82732389
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82702081
89Viral carcinogenesis_Homo sapiens_hsa052030.81285963
90Inositol phosphate metabolism_Homo sapiens_hsa005620.80643592
91Nicotine addiction_Homo sapiens_hsa050330.79851764
92Basal cell carcinoma_Homo sapiens_hsa052170.79689689
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78004154
94Osteoclast differentiation_Homo sapiens_hsa043800.76300483
95Leishmaniasis_Homo sapiens_hsa051400.76262568
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75670396
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74866350
98Retinol metabolism_Homo sapiens_hsa008300.74842405
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74841969
100Pertussis_Homo sapiens_hsa051330.74640099
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73688151
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72949481
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72255277
104Linoleic acid metabolism_Homo sapiens_hsa005910.72183585
105Rap1 signaling pathway_Homo sapiens_hsa040150.71797680
106Hepatitis B_Homo sapiens_hsa051610.71725165
107Viral myocarditis_Homo sapiens_hsa054160.71353096
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70588139
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68995231
110TNF signaling pathway_Homo sapiens_hsa046680.68809861
111Choline metabolism in cancer_Homo sapiens_hsa052310.68451309
112Salivary secretion_Homo sapiens_hsa049700.68378407
113Wnt signaling pathway_Homo sapiens_hsa043100.67415509
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67215107
115Non-small cell lung cancer_Homo sapiens_hsa052230.65858566
116Platelet activation_Homo sapiens_hsa046110.65551877
117Melanoma_Homo sapiens_hsa052180.65411779
118Other glycan degradation_Homo sapiens_hsa005110.65105950
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64856077
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64516848
121Melanogenesis_Homo sapiens_hsa049160.63936665
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63866479
123Antigen processing and presentation_Homo sapiens_hsa046120.63271646
124Epstein-Barr virus infection_Homo sapiens_hsa051690.62461398
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61993475
126Axon guidance_Homo sapiens_hsa043600.60738105
127Arginine biosynthesis_Homo sapiens_hsa002200.58636121
128Biosynthesis of amino acids_Homo sapiens_hsa012300.57020936
129Calcium signaling pathway_Homo sapiens_hsa040200.56986493
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56904086
131Endocytosis_Homo sapiens_hsa041440.56649645
132Mineral absorption_Homo sapiens_hsa049780.56476548
133Rheumatoid arthritis_Homo sapiens_hsa053230.56413810
134Pentose phosphate pathway_Homo sapiens_hsa000300.56309260
135Vibrio cholerae infection_Homo sapiens_hsa051100.55948581
136Caffeine metabolism_Homo sapiens_hsa002320.55195495
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55015380
138Dorso-ventral axis formation_Homo sapiens_hsa043200.54844152
139Long-term depression_Homo sapiens_hsa047300.54818187
140Legionellosis_Homo sapiens_hsa051340.54365836
141Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53525305
142Gap junction_Homo sapiens_hsa045400.53438787
143Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53316939
144Maturity onset diabetes of the young_Homo sapiens_hsa049500.52984477
145Fatty acid biosynthesis_Homo sapiens_hsa000610.52729548
146Arachidonic acid metabolism_Homo sapiens_hsa005900.52552749
147ErbB signaling pathway_Homo sapiens_hsa040120.49996334
148Phagosome_Homo sapiens_hsa041450.49525707
149Hepatitis C_Homo sapiens_hsa051600.49155919
150Tuberculosis_Homo sapiens_hsa051520.48820365
151Oxidative phosphorylation_Homo sapiens_hsa001900.47930337
152T cell receptor signaling pathway_Homo sapiens_hsa046600.47915354
153Ras signaling pathway_Homo sapiens_hsa040140.47195442
154Vascular smooth muscle contraction_Homo sapiens_hsa042700.46118117
155MAPK signaling pathway_Homo sapiens_hsa040100.45277152
156Metabolic pathways_Homo sapiens_hsa011000.44932340
157Malaria_Homo sapiens_hsa051440.43537989
158Arginine and proline metabolism_Homo sapiens_hsa003300.42064271
159Circadian rhythm_Homo sapiens_hsa047100.40545961
160Vitamin digestion and absorption_Homo sapiens_hsa049770.39852712
161Lysosome_Homo sapiens_hsa041420.39834726
162Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39455354
163Serotonergic synapse_Homo sapiens_hsa047260.38416996
164Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38396909
165Base excision repair_Homo sapiens_hsa034100.36393699
166SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29224294
167Circadian entrainment_Homo sapiens_hsa047130.24937815
168Amphetamine addiction_Homo sapiens_hsa050310.24144250
169Nucleotide excision repair_Homo sapiens_hsa034200.23931849
170Oxytocin signaling pathway_Homo sapiens_hsa049210.18270742
171Gastric acid secretion_Homo sapiens_hsa049710.17614683

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