ATG2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cholesterol homeostasis (GO:2000188)5.06379428
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.71793866
3negative regulation of cell killing (GO:0031342)4.71793866
4serine family amino acid catabolic process (GO:0009071)4.57103504
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.47771211
6negative regulation of erythrocyte differentiation (GO:0045647)4.47252103
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.43308277
8glycine metabolic process (GO:0006544)4.38870929
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.33298937
10L-phenylalanine metabolic process (GO:0006558)4.33298937
11positive regulation of gamma-delta T cell activation (GO:0046645)4.32980358
12urea cycle (GO:0000050)4.30220449
13urea metabolic process (GO:0019627)4.30220449
14cysteine metabolic process (GO:0006534)4.20579536
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.18875960
16positive regulation by organism of defense response of other organism involved in symbiotic interact4.18875960
17modulation by symbiont of host immune response (GO:0052553)4.18875960
18positive regulation by symbiont of host defense response (GO:0052509)4.18875960
19modulation by symbiont of host defense response (GO:0052031)4.18875960
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.18875960
21fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.16112522
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.14884677
23antigen processing and presentation of endogenous antigen (GO:0019883)4.13068038
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.11223115
25L-phenylalanine catabolic process (GO:0006559)4.10265398
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.10265398
27alpha-linolenic acid metabolic process (GO:0036109)4.07937853
28detection of other organism (GO:0098543)4.02319728
29kynurenine metabolic process (GO:0070189)3.99860855
30amino-acid betaine metabolic process (GO:0006577)3.94439787
31detection of bacterium (GO:0016045)3.93357995
32nitrogen cycle metabolic process (GO:0071941)3.88156441
33response to muramyl dipeptide (GO:0032495)3.82141442
34response to peptidoglycan (GO:0032494)3.81041285
35negative regulation of sterol transport (GO:0032372)3.77211441
36negative regulation of cholesterol transport (GO:0032375)3.77211441
37sulfur amino acid catabolic process (GO:0000098)3.75157880
38aromatic amino acid family catabolic process (GO:0009074)3.72941764
39regulation of protein activation cascade (GO:2000257)3.70671118
40negative regulation of fibrinolysis (GO:0051918)3.70084365
41leukocyte aggregation (GO:0070486)3.68096865
42lysine metabolic process (GO:0006553)3.67818120
43lysine catabolic process (GO:0006554)3.67818120
44complement activation, alternative pathway (GO:0006957)3.64995682
45tryptophan catabolic process (GO:0006569)3.60228636
46indole-containing compound catabolic process (GO:0042436)3.60228636
47indolalkylamine catabolic process (GO:0046218)3.60228636
48folic acid metabolic process (GO:0046655)3.57081106
49regulation of triglyceride catabolic process (GO:0010896)3.56954511
50serine family amino acid metabolic process (GO:0009069)3.56753255
51fructose metabolic process (GO:0006000)3.54727933
52negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.54686859
53regulation of complement activation (GO:0030449)3.51971610
54protein carboxylation (GO:0018214)3.50418214
55peptidyl-glutamic acid carboxylation (GO:0017187)3.50418214
56dicarboxylic acid biosynthetic process (GO:0043650)3.49831328
57homocysteine metabolic process (GO:0050667)3.49446596
58positive thymic T cell selection (GO:0045059)3.48188057
59mannose metabolic process (GO:0006013)3.47183662
60phospholipid homeostasis (GO:0055091)3.46484358
61macrophage activation involved in immune response (GO:0002281)3.46204056
62bile acid biosynthetic process (GO:0006699)3.44247540
63tolerance induction (GO:0002507)3.40431569
64valine metabolic process (GO:0006573)3.40245429
65positive regulation of triglyceride metabolic process (GO:0090208)3.40098175
662-oxoglutarate metabolic process (GO:0006103)3.39833060
67detection of external biotic stimulus (GO:0098581)3.39706248
68positive regulation of triglyceride biosynthetic process (GO:0010867)3.38038516
69glyoxylate metabolic process (GO:0046487)3.36618850
70regulation of cholesterol storage (GO:0010885)3.34563472
71cellular extravasation (GO:0045123)3.33149961
72thymic T cell selection (GO:0045061)3.33015062
73regulation of fatty acid beta-oxidation (GO:0031998)3.32840117
74tryptophan metabolic process (GO:0006568)3.30065432
75high-density lipoprotein particle remodeling (GO:0034375)3.29608032
76positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.29131097
77positive regulation of fatty acid beta-oxidation (GO:0032000)3.27052116
78germinal center formation (GO:0002467)3.26275135
79positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.24092346
80plasma lipoprotein particle assembly (GO:0034377)3.23789352
81neutrophil activation involved in immune response (GO:0002283)3.22019283
82phospholipid efflux (GO:0033700)3.18960838
83plasma lipoprotein particle clearance (GO:0034381)3.16598251
84low-density lipoprotein particle clearance (GO:0034383)3.16023379
85regulation of gamma-delta T cell differentiation (GO:0045586)3.15764643
86regulation of B cell receptor signaling pathway (GO:0050855)3.15587446
87positive regulation of triglyceride lipase activity (GO:0061365)3.13663515
88positive regulation of lipoprotein lipase activity (GO:0051006)3.13663515
89detection of molecule of bacterial origin (GO:0032490)3.13498193
90regulation of interferon-beta biosynthetic process (GO:0045357)3.13059294
91regulation of fibrinolysis (GO:0051917)3.10316157
92positive regulation of lipid catabolic process (GO:0050996)3.09963505
93response to laminar fluid shear stress (GO:0034616)3.09901652
94bile acid metabolic process (GO:0008206)3.07744679
95protein-lipid complex assembly (GO:0065005)3.07410750
96negative thymic T cell selection (GO:0045060)3.06252885
97fatty acid transmembrane transport (GO:1902001)3.05464988
98regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.03938380
99reverse cholesterol transport (GO:0043691)3.03892906
100alpha-amino acid catabolic process (GO:1901606)3.03400725
101T cell selection (GO:0045058)3.02809197
102serine family amino acid biosynthetic process (GO:0009070)3.02043163
103detection of biotic stimulus (GO:0009595)3.00610513
104negative regulation of fatty acid biosynthetic process (GO:0045717)2.99167895
105regulation of translational termination (GO:0006449)2.99026584
106carnitine shuttle (GO:0006853)2.98049903
107positive T cell selection (GO:0043368)2.98042861
108response to interleukin-15 (GO:0070672)2.96902131
109positive regulation of Cdc42 GTPase activity (GO:0043089)2.95906568
110neutrophil activation (GO:0042119)2.94541735
111negative T cell selection (GO:0043383)2.93373802
112triglyceride homeostasis (GO:0070328)2.92586986
113acylglycerol homeostasis (GO:0055090)2.92586986
114negative regulation of toll-like receptor signaling pathway (GO:0034122)2.92553031
115negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.92445043
116negative regulation of lymphocyte mediated immunity (GO:0002707)2.91801872
117aromatic amino acid family metabolic process (GO:0009072)2.91666216
118negative regulation of lipid transport (GO:0032369)2.91384214
119negative regulation of leukocyte mediated immunity (GO:0002704)2.88809259
120positive regulation of lipid storage (GO:0010884)2.88725091
121regulation of bile acid biosynthetic process (GO:0070857)2.88111773
122cholesterol homeostasis (GO:0042632)2.88100726
123carnitine metabolic process (GO:0009437)2.87366163
124regulation of triglyceride biosynthetic process (GO:0010866)2.86727001
125regulation of cholesterol esterification (GO:0010872)2.86486722
126NIK/NF-kappaB signaling (GO:0038061)2.85701418
127glutamate metabolic process (GO:0006536)2.85414645
128regulation of gamma-delta T cell activation (GO:0046643)2.84869976
129negative regulation of interleukin-12 production (GO:0032695)2.84761163
130regulation of leukocyte degranulation (GO:0043300)2.84473979
131sterol homeostasis (GO:0055092)2.82285488
132response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.82065839
133response to host (GO:0075136)2.82065839
134response to host defenses (GO:0052200)2.82065839
135granulocyte activation (GO:0036230)2.81803086
136antigen processing and presentation via MHC class Ib (GO:0002475)2.80180782
137histone H3-K36 demethylation (GO:0070544)2.79665375
138cellular amino acid catabolic process (GO:0009063)2.79190762
139fatty acid homeostasis (GO:0055089)2.77326379
140response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.77305991
141response to host immune response (GO:0052572)2.77305991
142regulation of myeloid leukocyte mediated immunity (GO:0002886)2.77014894
143macroautophagy (GO:0016236)2.76933908
144regulation of ARF protein signal transduction (GO:0032012)2.75663159
1453-UTR-mediated mRNA stabilization (GO:0070935)2.75289046
146regulation of triglyceride metabolic process (GO:0090207)2.75044869
147protein localization to endosome (GO:0036010)2.74180574
148positive regulation of fatty acid biosynthetic process (GO:0045723)2.74128693
149negative regulation of interleukin-6 production (GO:0032715)2.73997126
150intestinal cholesterol absorption (GO:0030299)2.73415784
151protein-lipid complex remodeling (GO:0034368)2.72893547
152macromolecular complex remodeling (GO:0034367)2.72893547
153plasma lipoprotein particle remodeling (GO:0034369)2.72893547
154interferon-gamma secretion (GO:0072643)2.72709535
155cholesterol efflux (GO:0033344)2.71901736
156acetyl-CoA metabolic process (GO:0006084)2.70766005
157positive regulation of histone deacetylation (GO:0031065)2.68684822
158lipopolysaccharide-mediated signaling pathway (GO:0031663)2.68360553
159regulation of mast cell degranulation (GO:0043304)2.68338193
160regulation of fatty acid biosynthetic process (GO:0042304)2.68258103
161very-low-density lipoprotein particle assembly (GO:0034379)2.67427807
162carnitine transmembrane transport (GO:1902603)2.67419310
163ethanol oxidation (GO:0006069)2.65637763
164apoptotic process involved in morphogenesis (GO:0060561)2.65260014
165cellular modified amino acid catabolic process (GO:0042219)2.65256293
166negative regulation of innate immune response (GO:0045824)2.62811741
167negative regulation of cAMP-mediated signaling (GO:0043951)2.61572222
168embryonic process involved in female pregnancy (GO:0060136)2.60547564
169regulation of ARF GTPase activity (GO:0032312)2.58440091
170B cell receptor signaling pathway (GO:0050853)2.57755752
171regulation of T-helper 2 cell differentiation (GO:0045628)2.55646387
172positive regulation of protein deacetylation (GO:0090312)2.54687383
173positive regulation of cellular amide metabolic process (GO:0034250)2.53728385
174positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.53299968
175signal complex assembly (GO:0007172)2.50502034
176respiratory burst (GO:0045730)2.49451168
177regulation of necroptotic process (GO:0060544)2.48976282
178negative regulation of glycoprotein biosynthetic process (GO:0010561)2.44671950
179response to type I interferon (GO:0034340)2.44269123
180positive regulation of Rap GTPase activity (GO:0032854)2.43537100
181macrophage activation (GO:0042116)2.43395421
182myeloid cell activation involved in immune response (GO:0002275)2.43131420
183leukocyte migration involved in inflammatory response (GO:0002523)2.42810938
184cellular response to type I interferon (GO:0071357)2.42237750
185type I interferon signaling pathway (GO:0060337)2.42237750
186regulation of regulated secretory pathway (GO:1903305)2.41745672
187JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.39454251
188production of molecular mediator involved in inflammatory response (GO:0002532)2.39182230
189modulation by virus of host process (GO:0019054)2.39058777
190negative regulation of interleukin-8 production (GO:0032717)2.38671928
191modulation by symbiont of host cellular process (GO:0044068)2.38500505
192negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.36034998
193regulation of mast cell activation involved in immune response (GO:0033006)2.34961754
194cellular response to interleukin-15 (GO:0071350)2.34530434
195negative regulation of T cell mediated immunity (GO:0002710)2.33713893
196regulation of type I interferon-mediated signaling pathway (GO:0060338)2.33265712

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.23440601
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.91019054
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.83042581
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.02288837
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.72816177
6MYC_22102868_ChIP-Seq_BL_Human2.55406189
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.54840585
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.48105889
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.27594731
10ZNF263_19887448_ChIP-Seq_K562_Human2.25459896
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.22664279
12VDR_24763502_ChIP-Seq_THP-1_Human2.15956693
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.15804076
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.11913920
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.02095902
16EGR1_19374776_ChIP-ChIP_THP-1_Human1.99794994
17BP1_19119308_ChIP-ChIP_Hs578T_Human1.99107743
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.95397881
19STAT3_1855785_ChIP-Seq_MESCs_Mouse1.94347533
20TCF7_22412390_ChIP-Seq_EML_Mouse1.88536134
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76215968
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.73096849
23KDM2B_26808549_Chip-Seq_DND41_Human1.70693916
24VDR_21846776_ChIP-Seq_THP-1_Human1.69523079
25* ELK3_25401928_ChIP-Seq_HUVEC_Human1.68765765
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.68447388
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68270560
28SPI1_23127762_ChIP-Seq_K562_Human1.64180021
29* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57381995
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55887706
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55874208
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54896010
33* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.53198879
34MAF_26560356_Chip-Seq_TH1_Human1.52132647
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51400630
36LXR_22292898_ChIP-Seq_THP-1_Human1.51053994
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50407451
38RUNX_20019798_ChIP-Seq_JUKART_Human1.48695938
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.48693066
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46758835
41* RACK7_27058665_Chip-Seq_MCF-7_Human1.45607778
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.42947509
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.42670424
44* SA1_27219007_Chip-Seq_ERYTHROID_Human1.41868598
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38614571
46IRF8_22096565_ChIP-ChIP_GC-B_Human1.38505504
47NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.35403829
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.34783328
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34156216
50CLOCK_20551151_ChIP-Seq_293T_Human1.33649410
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33441760
52EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33427927
53GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32897715
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.32774343
55UTX_26944678_Chip-Seq_JUKART_Human1.32658985
56* ATF3_27146783_Chip-Seq_COLON_Human1.32657837
57* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32535017
58P68_20966046_ChIP-Seq_HELA_Human1.30059994
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29824406
60NCOR1_26117541_ChIP-Seq_K562_Human1.29554646
61SPI1_23547873_ChIP-Seq_NB4_Human1.26877729
62MYB_26560356_Chip-Seq_TH2_Human1.24435738
63E2F7_22180533_ChIP-Seq_HELA_Human1.24031904
64* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23968225
65GATA1_19941826_ChIP-Seq_K562_Human1.23642075
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.23497857
67IRF8_21731497_ChIP-ChIP_J774_Mouse1.22983408
68STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22869970
69MAF_26560356_Chip-Seq_TH2_Human1.18377178
70* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18362380
71BCOR_27268052_Chip-Seq_Bcells_Human1.18133811
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.17534059
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16465309
74MYB_26560356_Chip-Seq_TH1_Human1.15776246
75* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14069573
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13890143
77STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12807826
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11888148
79ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11668467
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11654089
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10895844
82* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08723843
83GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08670114
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.07176181
85PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06513761
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06432022
87BCL6_27268052_Chip-Seq_Bcells_Human1.06038403
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05802733
89KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05521112
90CIITA_25753668_ChIP-Seq_RAJI_Human1.05298075
91SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04142531
92EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02187981
93MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02183724
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01463064
95RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01378189
96SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00822542
97CREB1_26743006_Chip-Seq_LNCaP_Human1.00269506
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99858471
99NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99629371
100P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99536574
101PHF8_20622854_ChIP-Seq_HELA_Human0.99415162
102IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98431272
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98268231
104* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97808386
105P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97367934
106* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.97239372
107GATA1_22025678_ChIP-Seq_K562_Human0.97078751
108PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96397232
109MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96259800
110GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95935055
111* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.94910146
112RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94860005
113TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94785216
114RUNX1_27514584_Chip-Seq_MCF-7_Human0.94619966
115SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94215784
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94142157
117SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94131374
118TP63_17297297_ChIP-ChIP_HaCaT_Human0.94107499
119* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93824895
120* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.93768066
121SCL_19346495_ChIP-Seq_HPC-7_Human0.93744505
122GATA6_25053715_ChIP-Seq_YYC3_Human0.93539933
123NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93262849
124SMC4_20622854_ChIP-Seq_HELA_Human0.93236711
125RUNX1_22412390_ChIP-Seq_EML_Mouse0.93062374
126* TET1_21451524_ChIP-Seq_MESCs_Mouse0.90923857
127KDM5A_27292631_Chip-Seq_BREAST_Human0.90851677
128* FOXA2_19822575_ChIP-Seq_HepG2_Human0.89925908
129KDM2B_26808549_Chip-Seq_K562_Human0.88829931
130KDM2B_26808549_Chip-Seq_JURKAT_Human0.88742881
131CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88348509
132* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.88311599
133ESR1_21235772_ChIP-Seq_MCF-7_Human0.87771921
134ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86964494
135NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.86683623
136SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85793956

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.41591735
2MP0005360_urolithiasis4.34686807
3MP0009840_abnormal_foam_cell4.26945159
4MP0005365_abnormal_bile_salt3.74063445
5MP0005085_abnormal_gallbladder_physiolo3.52827930
6MP0003705_abnormal_hypodermis_morpholog3.02442291
7MP0008260_abnormal_autophagy2.99795450
8MP0003724_increased_susceptibility_to2.82128350
9MP0003806_abnormal_nucleotide_metabolis2.79666441
10MP0010329_abnormal_lipoprotein_level2.70762622
11MP0003172_abnormal_lysosome_physiology2.46764272
12MP0005670_abnormal_white_adipose2.46233019
13MP0003252_abnormal_bile_duct2.44712900
14MP0003191_abnormal_cellular_cholesterol2.40759558
15MP0008875_abnormal_xenobiotic_pharmacok2.38132906
16MP0002419_abnormal_innate_immunity2.30145684
17MP0000609_abnormal_liver_physiology2.11566874
18MP0001835_abnormal_antigen_presentation2.06606111
19MP0004381_abnormal_hair_follicle2.06063802
20MP0009333_abnormal_splenocyte_physiolog2.03702706
21MP0005000_abnormal_immune_tolerance2.03268909
22MP0002420_abnormal_adaptive_immunity1.84905740
23MP0001533_abnormal_skeleton_physiology1.83815183
24MP0001819_abnormal_immune_cell1.83014522
25MP0010352_gastrointestinal_tract_polyps1.79975654
26MP0005332_abnormal_amino_acid1.79414019
27MP0009278_abnormal_bone_marrow1.77373849
28MP0005083_abnormal_biliary_tract1.76549576
29MP0002254_reproductive_system_inflammat1.69137934
30MP0001666_abnormal_nutrient_absorption1.67280234
31MP0003656_abnormal_erythrocyte_physiolo1.66116045
32MP0009785_altered_susceptibility_to1.60796787
33MP0002118_abnormal_lipid_homeostasis1.57828220
34MP0004019_abnormal_vitamin_homeostasis1.57506758
35MP0002138_abnormal_hepatobiliary_system1.57266511
36MP0005671_abnormal_response_to1.56550988
37MP0008961_abnormal_basal_metabolism1.54323609
38MP0002405_respiratory_system_inflammati1.52393223
39MP0005666_abnormal_adipose_tissue1.51544597
40MP0003828_pulmonary_edema1.51221351
41MP0005319_abnormal_enzyme/_coenzyme1.51070877
42MP0004858_abnormal_nervous_system1.51036128
43MP0003300_gastrointestinal_ulcer1.50608697
44MP0005076_abnormal_cell_differentiation1.46109923
45MP0000716_abnormal_immune_system1.44489134
46MP0004947_skin_inflammation1.43000336
47MP0003436_decreased_susceptibility_to1.42563063
48MP0002998_abnormal_bone_remodeling1.38905472
49MP0003111_abnormal_nucleus_morphology1.37098520
50MP0000858_altered_metastatic_potential1.35622867
51MP0001545_abnormal_hematopoietic_system1.32579170
52MP0005397_hematopoietic_system_phenotyp1.32579170
53MP0002148_abnormal_hypersensitivity_rea1.29384355
54MP0003693_abnormal_embryo_hatching1.29257607
55MP0003866_abnormal_defecation1.28359499
56MP0003045_fibrosis1.28109980
57MP0003566_abnormal_cell_adhesion1.26650425
58MP0002166_altered_tumor_susceptibility1.25598863
59MP0004130_abnormal_muscle_cell1.25134399
60MP0002132_abnormal_respiratory_system1.23522204
61MP0005310_abnormal_salivary_gland1.22874705
62MP0001851_eye_inflammation1.22358221
63MP0005451_abnormal_body_composition1.22289887
64MP0000598_abnormal_liver_morphology1.19915989
65MP0002429_abnormal_blood_cell1.18679058
66MP0005023_abnormal_wound_healing1.18334625
67MP0005409_darkened_coat_color1.17633787
68MP0004185_abnormal_adipocyte_glucose1.17234469
69MP0003303_peritoneal_inflammation1.16957411
70MP0000604_amyloidosis1.16105335
71MP0003091_abnormal_cell_migration1.14263526
72MP0006082_CNS_inflammation1.13906983
73MP0002933_joint_inflammation1.12399083
74MP0001853_heart_inflammation1.11773088
75MP0010307_abnormal_tumor_latency1.11287352
76MP0000678_abnormal_parathyroid_gland1.10455782
77MP0000685_abnormal_immune_system1.10107079
78MP0005464_abnormal_platelet_physiology1.09022867
79MP0009643_abnormal_urine_homeostasis1.08679739
80MP0004510_myositis1.07095216
81MP0002269_muscular_atrophy1.05249586
82MP0003075_altered_response_to1.04837086
83MP0004264_abnormal_extraembryonic_tissu1.02729889
84MP0005375_adipose_tissue_phenotype0.98771095
85MP0002009_preneoplasia0.97893623
86MP0001800_abnormal_humoral_immune0.96579050
87MP0003646_muscle_fatigue0.95211130
88MP0001764_abnormal_homeostasis0.95192638
89MP0003195_calcinosis0.93490617
90MP0001348_abnormal_lacrimal_gland0.92655751
91MP0000465_gastrointestinal_hemorrhage0.91895562
92MP0003453_abnormal_keratinocyte_physiol0.90660251
93MP0005058_abnormal_lysosome_morphology0.89376301
94MP0003329_amyloid_beta_deposits0.88155702
95MP0002877_abnormal_melanocyte_morpholog0.87189267
96MP0008469_abnormal_protein_level0.86811924
97MP0002796_impaired_skin_barrier0.86673755
98MP0010630_abnormal_cardiac_muscle0.85210163
99MP0005390_skeleton_phenotype0.84218615
100MP0001849_ear_inflammation0.83979511
101MP0003763_abnormal_thymus_physiology0.82896970
102MP0009931_abnormal_skin_appearance0.82407786
103MP0003183_abnormal_peptide_metabolism0.82086472
104MP0000689_abnormal_spleen_morphology0.81936063
105MP0001730_embryonic_growth_arrest0.81583922
106MP0002971_abnormal_brown_adipose0.81392804
107MP0009763_increased_sensitivity_to0.80222206
108MP0002136_abnormal_kidney_physiology0.79553190
109MP0002722_abnormal_immune_system0.79426474
110MP0005166_decreased_susceptibility_to0.78023632
111MP0005334_abnormal_fat_pad0.77973603
112MP0005501_abnormal_skin_physiology0.77819129
113MP0002088_abnormal_embryonic_growth/wei0.77716825
114MP0005584_abnormal_enzyme/coenzyme_acti0.77556853
115MP0003984_embryonic_growth_retardation0.76592340
116MP0009764_decreased_sensitivity_to0.76201594
117MP0004883_abnormal_blood_vessel0.75857907
118MP0009115_abnormal_fat_cell0.75675907
119MP0001790_abnormal_immune_system0.74713165
120MP0005387_immune_system_phenotype0.74713165
121MP0004808_abnormal_hematopoietic_stem0.74589744
122MP0002332_abnormal_exercise_endurance0.74283309
123MP0002086_abnormal_extraembryonic_tissu0.74180692
124MP0002970_abnormal_white_adipose0.73667524
125MP0002006_tumorigenesis0.73433495
126MP0005380_embryogenesis_phenotype0.72883589
127MP0001672_abnormal_embryogenesis/_devel0.72883589
128MP0009672_abnormal_birth_weight0.72287756
129MP0001756_abnormal_urination0.72225114
130MP0005164_abnormal_response_to0.72075289
131MP0002398_abnormal_bone_marrow0.71847543
132MP0008004_abnormal_stomach_pH0.71689105
133MP0000249_abnormal_blood_vessel0.70813496
134MP0001845_abnormal_inflammatory_respons0.69974084
135MP0002396_abnormal_hematopoietic_system0.69704980
136MP0003878_abnormal_ear_physiology0.69179186
137MP0005377_hearing/vestibular/ear_phenot0.69179186
138MP0001873_stomach_inflammation0.69167355
139MP0010155_abnormal_intestine_physiology0.67745107
140MP0002723_abnormal_immune_serum0.67500753
141MP0010234_abnormal_vibrissa_follicle0.66540959
142MP0000371_diluted_coat_color0.63756735
143MP0004084_abnormal_cardiac_muscle0.63465283
144MP0003077_abnormal_cell_cycle0.63244294
145MP0005025_abnormal_response_to0.63242656
146MP0000703_abnormal_thymus_morphology0.63037581
147MP0002452_abnormal_antigen_presenting0.62850918
148MP0002060_abnormal_skin_morphology0.62463794
149MP0004087_abnormal_muscle_fiber0.62207376
150MP0009642_abnormal_blood_homeostasis0.61549514

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.19708160
2Deep venous thrombosis (HP:0002625)4.65649577
3Xanthomatosis (HP:0000991)4.38341044
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.02577301
5Intrahepatic cholestasis (HP:0001406)3.99970353
6Hyperglycinuria (HP:0003108)3.88429292
7Abnormality of macrophages (HP:0004311)3.67069450
8Myositis (HP:0100614)3.64597334
9Abnormality of aromatic amino acid family metabolism (HP:0004338)3.63239545
10Myocardial infarction (HP:0001658)3.60561410
11Recurrent abscess formation (HP:0002722)3.52024035
12Complement deficiency (HP:0004431)3.50037287
13Hyperlipoproteinemia (HP:0010980)3.48111973
14Hyperglycinemia (HP:0002154)3.47197814
15Recurrent bacterial skin infections (HP:0005406)3.46686515
16Hypobetalipoproteinemia (HP:0003563)3.43784062
17Orchitis (HP:0100796)3.40805717
18Hypoalphalipoproteinemia (HP:0003233)3.37748633
19Obstructive sleep apnea (HP:0002870)3.36234743
20Abnormality of sulfur amino acid metabolism (HP:0004339)3.31878500
21Abnormality of glycine metabolism (HP:0010895)3.28165736
22Abnormality of serine family amino acid metabolism (HP:0010894)3.28165736
23Hypolipoproteinemia (HP:0010981)3.20060663
24Elevated erythrocyte sedimentation rate (HP:0003565)3.10911491
25Gastrointestinal infarctions (HP:0005244)3.07527407
26Polycythemia (HP:0001901)3.05831596
27Hyperammonemia (HP:0001987)3.05239854
28Retrobulbar optic neuritis (HP:0100654)2.96066545
29Optic neuritis (HP:0100653)2.96066545
30Hypercholesterolemia (HP:0003124)2.95910786
31Stomatitis (HP:0010280)2.81630999
32Epidermoid cyst (HP:0200040)2.81087199
33Abnormality of complement system (HP:0005339)2.79841376
34Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.78445017
35Prolonged partial thromboplastin time (HP:0003645)2.75612272
36Recurrent fungal infections (HP:0002841)2.73010780
37Gingivitis (HP:0000230)2.72839817
38Broad face (HP:0000283)2.70039824
39Pustule (HP:0200039)2.65848477
40Cellulitis (HP:0100658)2.63061410
41Obstructive lung disease (HP:0006536)2.61245168
42Chronic obstructive pulmonary disease (HP:0006510)2.61245168
43Abnormality of the common coagulation pathway (HP:0010990)2.58865035
44Ketosis (HP:0001946)2.55776262
45Joint hemorrhage (HP:0005261)2.54285006
46Esophageal varix (HP:0002040)2.53636197
47Mediastinal lymphadenopathy (HP:0100721)2.52450601
48Atrioventricular block (HP:0001678)2.52244372
49Abnormality of glutamine family amino acid metabolism (HP:0010902)2.51625025
50Global brain atrophy (HP:0002283)2.50596358
51Abnormal delayed hypersensitivity skin test (HP:0002963)2.49148045
52Abnormality of the lower motor neuron (HP:0002366)2.46289569
53Prolonged bleeding time (HP:0003010)2.46247560
54Abnormality of pyrimidine metabolism (HP:0004353)2.45191742
55Meningitis (HP:0001287)2.42863356
56Gastrointestinal inflammation (HP:0004386)2.42496283
57Reticulocytosis (HP:0001923)2.40693513
58Recurrent skin infections (HP:0001581)2.37868615
59Spontaneous hematomas (HP:0007420)2.35570934
60Segmental peripheral demyelination/remyelination (HP:0003481)2.35311422
61Gout (HP:0001997)2.34603238
62Poikilocytosis (HP:0004447)2.34209470
63Abnormality of methionine metabolism (HP:0010901)2.31941155
64Abnormality of fatty-acid metabolism (HP:0004359)2.30873990
65Hypochromic anemia (HP:0001931)2.28954223
66Alopecia of scalp (HP:0002293)2.28602182
67Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.28073946
68Bundle branch block (HP:0011710)2.26971153
69Slow saccadic eye movements (HP:0000514)2.26663013
70Difficulty climbing stairs (HP:0003551)2.23046236
71Inflammation of the large intestine (HP:0002037)2.22676738
72Autoimmune thrombocytopenia (HP:0001973)2.22005337
73Keratoconjunctivitis sicca (HP:0001097)2.20479183
74Chest pain (HP:0100749)2.18188275
75Skin nodule (HP:0200036)2.17821903
76Abnormality of aspartate family amino acid metabolism (HP:0010899)2.16261081
77Hypoglycemic coma (HP:0001325)2.16085109
78Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.15374284
79Vasculitis (HP:0002633)2.15283037
80Increased connective tissue (HP:0009025)2.15247498
81Cerebral aneurysm (HP:0004944)2.15164004
82Abnormality of nucleobase metabolism (HP:0010932)2.11378859
83Urticaria (HP:0001025)2.09147913
84Systemic lupus erythematosus (HP:0002725)2.07415433
85Epistaxis (HP:0000421)2.06903642
86Distal upper limb amyotrophy (HP:0007149)2.06837409
87Upper limb amyotrophy (HP:0009129)2.06837409
88Hyperglycemia (HP:0003074)2.06753691
89Dysmetric saccades (HP:0000641)2.06470065
90Distal lower limb amyotrophy (HP:0008944)2.06272880
91Gingival bleeding (HP:0000225)2.06015991
92Upper motor neuron abnormality (HP:0002127)2.05938460
93Dysostosis multiplex (HP:0000943)2.05904216
94Recurrent cutaneous fungal infections (HP:0011370)2.05341545
95Chronic mucocutaneous candidiasis (HP:0002728)2.05341545
96Nasal polyposis (HP:0100582)2.04868508
97Hemorrhage of the eye (HP:0011885)2.02434827
98Spastic diplegia (HP:0001264)2.01603785
99Recurrent gram-negative bacterial infections (HP:0005420)2.01249277
100Interstitial pulmonary disease (HP:0006530)2.00728283
101Abnormality of the Achilles tendon (HP:0005109)2.00223102
102Hand muscle atrophy (HP:0009130)1.99711905
103Increased cerebral lipofuscin (HP:0011813)1.99353557
104Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.98788774
105Acanthocytosis (HP:0001927)1.98326702
106Episodic fever (HP:0001954)1.97154056
107Abnormality of the fingertips (HP:0001211)1.96845174
108Abnormality of the nasal mucosa (HP:0000433)1.95883152
109Amyloidosis (HP:0011034)1.95755984
110Abnormality of purine metabolism (HP:0004352)1.94472417
111Easy fatigability (HP:0003388)1.94298898
112Keratoconjunctivitis (HP:0001096)1.93982523
113Recurrent viral infections (HP:0004429)1.93718760
114Hypochromic microcytic anemia (HP:0004840)1.92891988
115Thin bony cortex (HP:0002753)1.92854367
116Encephalitis (HP:0002383)1.92533029
117Onion bulb formation (HP:0003383)1.92293687
118Metaphyseal cupping (HP:0003021)1.91600190
119Abnormality of polysaccharide metabolism (HP:0011012)1.91567604
120Abnormality of glycosaminoglycan metabolism (HP:0004371)1.91567604
121Abnormality of mucopolysaccharide metabolism (HP:0011020)1.91567604
122Hypertriglyceridemia (HP:0002155)1.91036813
123Subacute progressive viral hepatitis (HP:0006572)1.90889856
124Abnormality of serum amino acid levels (HP:0003112)1.90528597
125Arterial thrombosis (HP:0004420)1.89156022
126Fat malabsorption (HP:0002630)1.88906549
127Heterotopia (HP:0002282)1.87831622
128Peritonitis (HP:0002586)1.85683375
129Disproportionate tall stature (HP:0001519)1.85551715
130Heart block (HP:0012722)1.84650860
131Stridor (HP:0010307)1.83053923
132Flat acetabular roof (HP:0003180)1.82588250
133Aneurysm (HP:0002617)1.82242113
134Increased variability in muscle fiber diameter (HP:0003557)1.81583050
135Right ventricular cardiomyopathy (HP:0011663)1.80751964
136Malnutrition (HP:0004395)1.80742661
137Hyperbilirubinemia (HP:0002904)1.80634646
138Mitral stenosis (HP:0001718)1.79301018
139Mucopolysacchariduria (HP:0008155)1.78057233
140Urinary glycosaminoglycan excretion (HP:0003541)1.78057233
141Impulsivity (HP:0100710)1.77771480
142Increased neuronal autofluorescent lipopigment (HP:0002074)1.77750742
143Polygenic inheritance (HP:0010982)1.77458979
144Dislocated radial head (HP:0003083)1.77424514
145Neonatal death (HP:0003811)1.77333152
146Abnormal atrioventricular conduction (HP:0005150)1.76989998
147Multiple enchondromatosis (HP:0005701)1.76910014
148Abnormality of the thoracic spine (HP:0100711)1.76760502
149Abnormality of iron homeostasis (HP:0011031)1.76480394
150Testicular atrophy (HP:0000029)1.76241032
151Cholelithiasis (HP:0001081)1.75899773
152Colitis (HP:0002583)1.75700549
153Pseudobulbar signs (HP:0002200)1.75483179
154Pulmonary infiltrates (HP:0002113)1.74861756
155Papilloma (HP:0012740)1.74422138
156Verrucae (HP:0200043)1.74422138
157Hemoptysis (HP:0002105)1.73977411
158Dicarboxylic aciduria (HP:0003215)1.73946140
159Abnormality of dicarboxylic acid metabolism (HP:0010995)1.73946140
160Abnormality of transition element cation homeostasis (HP:0011030)1.73449476
161Axonal loss (HP:0003447)1.73178339
162Vascular calcification (HP:0004934)1.73046723
163Long palpebral fissure (HP:0000637)1.72403304
164Sensorimotor neuropathy (HP:0007141)1.72269767
165Stroke (HP:0001297)1.71939940
166Difficulty running (HP:0009046)1.71831450
167Hepatocellular carcinoma (HP:0001402)1.71368259
168Acne (HP:0001061)1.70361220
169Centrally nucleated skeletal muscle fibers (HP:0003687)1.70330457
170Abnormality of the intrinsic pathway (HP:0010989)1.69836122
171Loss of speech (HP:0002371)1.69834336
172Spontaneous abortion (HP:0005268)1.68022979
173Increased serum ferritin (HP:0003281)1.67875658
174Osteomyelitis (HP:0002754)1.67267168
175Emphysema (HP:0002097)1.66913354
176Anorexia (HP:0002039)1.66809290
177Abnormal platelet volume (HP:0011876)1.65281284
178Tetraplegia (HP:0002445)1.64563883
179Abnormality of the distal phalanx of the thumb (HP:0009617)1.64349440
180Status epilepticus (HP:0002133)1.63351482
181Increased IgE level (HP:0003212)1.63197848
182J-shaped sella turcica (HP:0002680)1.62544026
183Abnormality of the radial head (HP:0003995)1.62525058

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.03746906
2PRPF4B3.52235505
3CDK123.32292709
4ERN13.17078667
5MAP4K12.87648510
6FGFR42.68571312
7IRAK32.68127244
8SMG12.63644269
9RIPK42.54364157
10PKN22.50874190
11MAP3K102.43787152
12EEF2K2.35169667
13BCKDK2.13644067
14EPHA22.10642538
15TNK21.96517732
16SIK11.96114414
17ICK1.82951512
18TTN1.79525850
19MARK21.70648568
20TAOK11.65687760
21RIPK11.60845191
22GRK61.60354068
23NEK21.53981449
24TYK21.53729428
25BLK1.50255524
26PTK61.48673117
27PRKD21.48284188
28MTOR1.44106422
29SIK31.36416050
30STK101.31520138
31EPHB11.30465233
32ZAP701.27105578
33TAOK21.25468177
34FES1.24340113
35CAMK1D1.22837206
36PDK41.22072117
37PDK31.22072117
38CDK41.20618087
39IRAK21.20390659
40MAP3K131.19897516
41ALK1.19038361
42MAP2K31.17364215
43JAK31.16281073
44KSR21.15143609
45MAP3K141.13649717
46BUB11.12994171
47JAK11.08173342
48TAOK31.07702463
49MAP3K111.04458027
50CDC42BPA1.04045426
51IRAK11.02008649
52MAP3K30.98817519
53HIPK20.98673738
54PIM10.97683755
55TBK10.96166426
56TTK0.94311342
57FGFR30.93770637
58STK380.93029156
59BMX0.89623940
60SGK30.88808938
61MAP3K70.87668525
62CAMK1G0.86129941
63LATS10.85737396
64MAPK110.84167028
65MAP3K60.82631200
66CHUK0.80968400
67JAK20.80219607
68PNCK0.79736566
69PTK20.79316931
70MAP3K80.79149151
71STK40.75632638
72TXK0.74789018
73LRRK20.74327275
74RPS6KA40.72728698
75RPS6KL10.72202600
76RPS6KC10.72202600
77RPS6KA20.72012467
78SIK20.70401014
79TYRO30.69697130
80TESK20.69438725
81PDK20.68658610
82PAK40.68566715
83IKBKB0.68322354
84CDK60.66697600
85HCK0.65664552
86CAMKK10.65102067
87NEK10.64617283
88MARK30.64359618
89MAP2K20.63312140
90SYK0.62632160
91BRD40.61921592
92RPS6KB20.61556960
93FGR0.61062112
94LCK0.60852523
95PRKAA10.60590345
96STK30.60518127
97MAP3K90.59111547
98RPS6KA60.57742133
99NLK0.56043990
100WEE10.54775305
101RET0.54677838
102PDGFRA0.53815326
103PDPK10.53457590
104PDK10.53344238
105IKBKE0.53082222
106ZAK0.52627939
107CSF1R0.52426164
108FLT30.50801288
109MAP3K20.49848709
110LYN0.48645340
111PLK40.47921828
112CSK0.47610597
113TGFBR20.47306947
114RPS6KA10.46497269
115ITK0.45553653
116PRKD30.45095003
117KDR0.44836005
118DYRK30.44440463
119MST1R0.44241312
120MAP3K10.43389703
121MELK0.43278713
122LATS20.42575981
123DYRK1B0.42125220
124MAP2K60.40846222
125MAPK70.40324250
126PRKAA20.40138878
127MAPK120.39268166
128CAMK40.38261465
129PRKG20.37399578
130BTK0.37125788
131MAPKAPK20.36214187
132CHEK10.35079629
133PRKCH0.33726569
134IRAK40.33521336
135PINK10.33494299
136STK110.33137065
137PDGFRB0.32651512

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.53453078
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.44239917
3Nitrogen metabolism_Homo sapiens_hsa009103.42979654
4Arginine biosynthesis_Homo sapiens_hsa002202.89360595
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.51211467
6Vitamin B6 metabolism_Homo sapiens_hsa007502.36442268
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.34339266
8Fatty acid degradation_Homo sapiens_hsa000712.25779181
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.21185657
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.13903716
11Complement and coagulation cascades_Homo sapiens_hsa046102.08893235
12Other glycan degradation_Homo sapiens_hsa005112.06993372
13Tryptophan metabolism_Homo sapiens_hsa003801.96922161
14PPAR signaling pathway_Homo sapiens_hsa033201.94201098
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.87339813
16Staphylococcus aureus infection_Homo sapiens_hsa051501.86701272
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.77525433
18Caffeine metabolism_Homo sapiens_hsa002321.73770890
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72392106
20VEGF signaling pathway_Homo sapiens_hsa043701.70400984
21Lysine degradation_Homo sapiens_hsa003101.70209120
22Selenocompound metabolism_Homo sapiens_hsa004501.63995373
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63917963
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.57705898
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.57624912
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52495497
27Fatty acid metabolism_Homo sapiens_hsa012121.52100722
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.51637932
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.45261569
30beta-Alanine metabolism_Homo sapiens_hsa004101.43265062
31Fat digestion and absorption_Homo sapiens_hsa049751.43264314
32Propanoate metabolism_Homo sapiens_hsa006401.40613666
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40321163
34TNF signaling pathway_Homo sapiens_hsa046681.39016123
35Folate biosynthesis_Homo sapiens_hsa007901.38894449
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.38431232
37Pancreatic cancer_Homo sapiens_hsa052121.38078526
38Biosynthesis of amino acids_Homo sapiens_hsa012301.37410726
39Tuberculosis_Homo sapiens_hsa051521.35648955
40Sulfur relay system_Homo sapiens_hsa041221.35251933
41Pentose phosphate pathway_Homo sapiens_hsa000301.35226340
42ABC transporters_Homo sapiens_hsa020101.34654781
43Bile secretion_Homo sapiens_hsa049761.31995996
44Renal cell carcinoma_Homo sapiens_hsa052111.31452411
45Endometrial cancer_Homo sapiens_hsa052131.30259622
46Carbon metabolism_Homo sapiens_hsa012001.30016539
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27979955
48Neurotrophin signaling pathway_Homo sapiens_hsa047221.26426826
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26262779
50Glycerolipid metabolism_Homo sapiens_hsa005611.25219256
51Hepatitis B_Homo sapiens_hsa051611.24254576
52Peroxisome_Homo sapiens_hsa041461.23801231
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23337563
54Hepatitis C_Homo sapiens_hsa051601.23211277
55Chemokine signaling pathway_Homo sapiens_hsa040621.21207922
56Glycosaminoglycan degradation_Homo sapiens_hsa005311.19054069
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18917184
58Butanoate metabolism_Homo sapiens_hsa006501.16247536
59Malaria_Homo sapiens_hsa051441.14586621
60Leukocyte transendothelial migration_Homo sapiens_hsa046701.12314991
61GnRH signaling pathway_Homo sapiens_hsa049121.10545694
62Choline metabolism in cancer_Homo sapiens_hsa052311.10273901
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10199154
64Starch and sucrose metabolism_Homo sapiens_hsa005001.10134097
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09682279
66Jak-STAT signaling pathway_Homo sapiens_hsa046301.08986366
67Prolactin signaling pathway_Homo sapiens_hsa049171.08457953
68Insulin resistance_Homo sapiens_hsa049311.07780723
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07773341
70Adipocytokine signaling pathway_Homo sapiens_hsa049201.07364124
71Phospholipase D signaling pathway_Homo sapiens_hsa040721.03678952
72Bladder cancer_Homo sapiens_hsa052191.01982034
73Fructose and mannose metabolism_Homo sapiens_hsa000511.01652376
74ErbB signaling pathway_Homo sapiens_hsa040121.01256351
75Chemical carcinogenesis_Homo sapiens_hsa052041.01021286
76One carbon pool by folate_Homo sapiens_hsa006700.99891088
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.99473101
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98706818
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98697940
80Herpes simplex infection_Homo sapiens_hsa051680.96166510
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.94699423
82Platelet activation_Homo sapiens_hsa046110.94619109
83Phenylalanine metabolism_Homo sapiens_hsa003600.93989777
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93703299
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93607997
86Histidine metabolism_Homo sapiens_hsa003400.92960835
87Retinol metabolism_Homo sapiens_hsa008300.91634878
88Endocytosis_Homo sapiens_hsa041440.90822416
89Vitamin digestion and absorption_Homo sapiens_hsa049770.88867008
90Fatty acid biosynthesis_Homo sapiens_hsa000610.83711757
91Colorectal cancer_Homo sapiens_hsa052100.82934719
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.82596698
93Glioma_Homo sapiens_hsa052140.82542483
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.81849819
95Prostate cancer_Homo sapiens_hsa052150.80468550
96Amoebiasis_Homo sapiens_hsa051460.80074660
97mTOR signaling pathway_Homo sapiens_hsa041500.79304133
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78919265
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78229195
100Acute myeloid leukemia_Homo sapiens_hsa052210.77322885
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77259768
102Graft-versus-host disease_Homo sapiens_hsa053320.75348181
103Legionellosis_Homo sapiens_hsa051340.74896004
104Pyruvate metabolism_Homo sapiens_hsa006200.74827067
105Viral carcinogenesis_Homo sapiens_hsa052030.74252744
106Hematopoietic cell lineage_Homo sapiens_hsa046400.73545437
107AMPK signaling pathway_Homo sapiens_hsa041520.73044774
108Thyroid cancer_Homo sapiens_hsa052160.72857371
109Estrogen signaling pathway_Homo sapiens_hsa049150.72589980
110Pertussis_Homo sapiens_hsa051330.72277595
111Allograft rejection_Homo sapiens_hsa053300.71557261
112Viral myocarditis_Homo sapiens_hsa054160.71449221
113Salmonella infection_Homo sapiens_hsa051320.71375960
114MAPK signaling pathway_Homo sapiens_hsa040100.70238144
115Lysosome_Homo sapiens_hsa041420.69990778
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69845721
117HIF-1 signaling pathway_Homo sapiens_hsa040660.69473196
118Shigellosis_Homo sapiens_hsa051310.67467545
119HTLV-I infection_Homo sapiens_hsa051660.67329149
120African trypanosomiasis_Homo sapiens_hsa051430.65548583
121Autoimmune thyroid disease_Homo sapiens_hsa053200.65055221
122Regulation of autophagy_Homo sapiens_hsa041400.64839824
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63761545
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63009519
125Galactose metabolism_Homo sapiens_hsa000520.60878280
126NF-kappa B signaling pathway_Homo sapiens_hsa040640.60603091
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60468278
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60256877
129Arginine and proline metabolism_Homo sapiens_hsa003300.60225048
130B cell receptor signaling pathway_Homo sapiens_hsa046620.59708729
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58153672
132Osteoclast differentiation_Homo sapiens_hsa043800.55173202
133Insulin signaling pathway_Homo sapiens_hsa049100.54525849
134Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53813332
135Proteoglycans in cancer_Homo sapiens_hsa052050.53040546
136Long-term potentiation_Homo sapiens_hsa047200.51140889
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50468177
138Rap1 signaling pathway_Homo sapiens_hsa040150.49817827
139Focal adhesion_Homo sapiens_hsa045100.49730525
140Dorso-ventral axis formation_Homo sapiens_hsa043200.44037948
141Glucagon signaling pathway_Homo sapiens_hsa049220.42540950
142Tyrosine metabolism_Homo sapiens_hsa003500.41018772
143Chronic myeloid leukemia_Homo sapiens_hsa052200.39506664
144Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39070006
145Apoptosis_Homo sapiens_hsa042100.38541816
146Primary immunodeficiency_Homo sapiens_hsa053400.38441067
147Glutathione metabolism_Homo sapiens_hsa004800.38423665
148Notch signaling pathway_Homo sapiens_hsa043300.37842834
149Central carbon metabolism in cancer_Homo sapiens_hsa052300.37830409
150Prion diseases_Homo sapiens_hsa050200.37361513
151FoxO signaling pathway_Homo sapiens_hsa040680.34682866
152Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34329335
153Type II diabetes mellitus_Homo sapiens_hsa049300.32191605
154Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28650128
155Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27986633
156Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27888158
157Toxoplasmosis_Homo sapiens_hsa051450.26794559
158Antigen processing and presentation_Homo sapiens_hsa046120.26733481
159T cell receptor signaling pathway_Homo sapiens_hsa046600.26144678
160Inositol phosphate metabolism_Homo sapiens_hsa005620.24744462
161Small cell lung cancer_Homo sapiens_hsa052220.24524136
162RNA transport_Homo sapiens_hsa030130.24241895
163Epstein-Barr virus infection_Homo sapiens_hsa051690.23851432
164Leishmaniasis_Homo sapiens_hsa051400.23607980
165Influenza A_Homo sapiens_hsa051640.23020945
166Non-small cell lung cancer_Homo sapiens_hsa052230.22548771
167Measles_Homo sapiens_hsa051620.21894141

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