ATG14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)6.09475862
2mitotic metaphase plate congression (GO:0007080)5.78142608
3nucleobase biosynthetic process (GO:0046112)5.55160415
4ribosome assembly (GO:0042255)5.29064946
5folic acid metabolic process (GO:0046655)4.83790692
6regulation of spindle organization (GO:0090224)4.72237511
7metaphase plate congression (GO:0051310)4.61310446
8negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.48033857
9DNA replication checkpoint (GO:0000076)4.46722784
10vitamin transmembrane transport (GO:0035461)4.43915352
11ribosome biogenesis (GO:0042254)4.30021460
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.29358975
13protein K11-linked deubiquitination (GO:0035871)4.25086044
14negative regulation of cAMP-mediated signaling (GO:0043951)4.23344481
15interkinetic nuclear migration (GO:0022027)4.19586932
16regulation of meiosis I (GO:0060631)4.19292358
17regulation of mitotic spindle organization (GO:0060236)4.11972139
18glycine metabolic process (GO:0006544)4.03913153
19protein localization to kinetochore (GO:0034501)4.03457027
20regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.03333594
21folic acid transport (GO:0015884)4.03230469
22regulation of retinoic acid receptor signaling pathway (GO:0048385)4.01645054
23positive regulation of chromosome segregation (GO:0051984)3.95503981
24formation of translation preinitiation complex (GO:0001731)3.89402030
25rRNA modification (GO:0000154)3.84706042
26pyrimidine dimer repair (GO:0006290)3.80959499
27male meiosis I (GO:0007141)3.77951017
28behavioral response to nicotine (GO:0035095)3.73744795
29serine family amino acid catabolic process (GO:0009071)3.73698082
30pantothenate metabolic process (GO:0015939)3.73295984
31protein K63-linked deubiquitination (GO:0070536)3.70901267
32establishment of protein localization to Golgi (GO:0072600)3.70276937
33attachment of spindle microtubules to kinetochore (GO:0008608)3.69016761
347-methylguanosine mRNA capping (GO:0006370)3.64572862
35mitotic nuclear envelope disassembly (GO:0007077)3.62360932
36DNA methylation involved in gamete generation (GO:0043046)3.62138165
37snRNA transcription (GO:0009301)3.61246016
38positive regulation of protein homooligomerization (GO:0032464)3.59664652
39transcription elongation from RNA polymerase III promoter (GO:0006385)3.57540662
40termination of RNA polymerase III transcription (GO:0006386)3.57540662
41regulation of translation in response to stress (GO:0043555)3.56055275
42transcription elongation from RNA polymerase I promoter (GO:0006362)3.55080938
43establishment of chromosome localization (GO:0051303)3.53643203
44RNA capping (GO:0036260)3.53612695
457-methylguanosine RNA capping (GO:0009452)3.53612695
46termination of RNA polymerase I transcription (GO:0006363)3.51592862
47intestinal epithelial cell development (GO:0060576)3.49724365
48protein localization to chromosome, centromeric region (GO:0071459)3.43619454
49transcription from RNA polymerase I promoter (GO:0006360)3.42224946
50spindle checkpoint (GO:0031577)3.41236492
51negative regulation of translation, ncRNA-mediated (GO:0040033)3.36040189
52regulation of translation, ncRNA-mediated (GO:0045974)3.36040189
53negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.36040189
54amino acid salvage (GO:0043102)3.36016471
55L-methionine salvage (GO:0071267)3.36016471
56L-methionine biosynthetic process (GO:0071265)3.36016471
57histone H3-K4 trimethylation (GO:0080182)3.35691274
58nuclear envelope disassembly (GO:0051081)3.35398992
59membrane disassembly (GO:0030397)3.35398992
60mitotic sister chromatid segregation (GO:0000070)3.34010269
61protein K6-linked ubiquitination (GO:0085020)3.31339413
62protein K48-linked deubiquitination (GO:0071108)3.30782388
63proteasome assembly (GO:0043248)3.29834691
64protein targeting to Golgi (GO:0000042)3.29190363
65mitotic spindle checkpoint (GO:0071174)3.28879329
66rRNA catabolic process (GO:0016075)3.28814962
67regulation of nuclear cell cycle DNA replication (GO:0033262)3.28012459
68blastocyst development (GO:0001824)3.27683885
69N-terminal protein amino acid acetylation (GO:0006474)3.27299900
70regulation of chromosome segregation (GO:0051983)3.26226208
71fucose catabolic process (GO:0019317)3.24850054
72L-fucose metabolic process (GO:0042354)3.24850054
73L-fucose catabolic process (GO:0042355)3.24850054
74anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.24706753
75negative regulation of chromosome segregation (GO:0051985)3.23244947
76histone H3-K36 demethylation (GO:0070544)3.22139081
77S-adenosylmethionine metabolic process (GO:0046500)3.21011087
78nuclear pore organization (GO:0006999)3.20416700
79GMP metabolic process (GO:0046037)3.19938146
80transcription initiation from RNA polymerase I promoter (GO:0006361)3.19870515
81negative regulation of DNA-dependent DNA replication (GO:2000104)3.19606373
82embryonic hemopoiesis (GO:0035162)3.19464850
83maturation of 5.8S rRNA (GO:0000460)3.16975540
84regulation of double-strand break repair via homologous recombination (GO:0010569)3.16335147
85kinetochore assembly (GO:0051382)3.15670697
86negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.14712006
87negative regulation of sister chromatid segregation (GO:0033046)3.14712006
88negative regulation of mitotic sister chromatid separation (GO:2000816)3.14712006
89negative regulation of mitotic sister chromatid segregation (GO:0033048)3.14712006
90mitotic spindle assembly checkpoint (GO:0007094)3.13732029
91regulation of mitotic metaphase/anaphase transition (GO:0030071)3.12824405
92retrograde transport, vesicle recycling within Golgi (GO:0000301)3.12446528
93oocyte maturation (GO:0001556)3.12160051
94DNA deamination (GO:0045006)3.11715071
95protoporphyrinogen IX metabolic process (GO:0046501)3.11628459
96rRNA methylation (GO:0031167)3.10438691
97detection of light stimulus involved in visual perception (GO:0050908)3.08892112
98detection of light stimulus involved in sensory perception (GO:0050962)3.08892112
99spindle assembly checkpoint (GO:0071173)3.08643250
100negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.08641996
101erythrocyte development (GO:0048821)3.08483793
102regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.08465737
103regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.08176844
104monoubiquitinated protein deubiquitination (GO:0035520)3.08140950
105methionine biosynthetic process (GO:0009086)3.06739645
106methionine metabolic process (GO:0006555)3.05723396
107meiosis I (GO:0007127)3.05340446
108multicellular organism reproduction (GO:0032504)3.05256164
109histone mRNA catabolic process (GO:0071044)3.04301847
110negative regulation of translational initiation (GO:0045947)3.03434129
111positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.02728530
112histone H2A monoubiquitination (GO:0035518)3.01603522
113retinal cone cell development (GO:0046549)3.00090115
114serine family amino acid metabolic process (GO:0009069)2.99601748
115sulfur amino acid biosynthetic process (GO:0000097)2.98742529
116modified amino acid transport (GO:0072337)2.98338762
117ribonucleoprotein complex biogenesis (GO:0022613)2.97993489
118transcription elongation from RNA polymerase II promoter (GO:0006368)2.97934356
119spliceosomal snRNP assembly (GO:0000387)2.97826945
120inner cell mass cell proliferation (GO:0001833)2.97734916
121DNA-templated transcription, elongation (GO:0006354)2.96295241
122maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.95939769
123positive regulation of viral transcription (GO:0050434)2.94696269
124detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.93104582
125hemoglobin metabolic process (GO:0020027)2.93077826
126RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.92714882
127DNA replication-dependent nucleosome assembly (GO:0006335)2.92577065
128DNA replication-dependent nucleosome organization (GO:0034723)2.92577065
129regulation of energy homeostasis (GO:2000505)2.92116382
130piRNA metabolic process (GO:0034587)2.91836723
131oxygen transport (GO:0015671)2.91729847
132microtubule depolymerization (GO:0007019)2.91322109
133rRNA processing (GO:0006364)2.91237698
134regulation of sister chromatid segregation (GO:0033045)2.91204167
135regulation of mitotic sister chromatid separation (GO:0010965)2.91204167
136regulation of mitotic sister chromatid segregation (GO:0033047)2.91204167
137replication fork processing (GO:0031297)2.91182959
138protein localization to chromosome (GO:0034502)2.91124349
139transcription from mitochondrial promoter (GO:0006390)2.90480429
140DNA replication initiation (GO:0006270)2.90335776
141phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.89826533
142regulation of G0 to G1 transition (GO:0070316)2.88679759
143prenylation (GO:0097354)2.88431723
144protein prenylation (GO:0018342)2.88431723
145positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.87791059
146regulation of DNA endoreduplication (GO:0032875)2.84157858
147centriole replication (GO:0007099)2.82173679
148regulation of acrosome reaction (GO:0060046)2.79840937
149erythrocyte maturation (GO:0043249)2.76153253
150gene silencing by RNA (GO:0031047)2.75907627
151magnesium ion transport (GO:0015693)2.75678904
152ncRNA catabolic process (GO:0034661)2.74310414
153glycine transport (GO:0015816)2.72113831
154protein localization to Golgi apparatus (GO:0034067)2.68562287
155preassembly of GPI anchor in ER membrane (GO:0016254)2.65954111
156positive regulation of meiosis (GO:0045836)2.65477286
157positive regulation of meiotic cell cycle (GO:0051446)2.65089814
158epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.65028847
159regulation of RNA export from nucleus (GO:0046831)2.63710070
160regulation of establishment of cell polarity (GO:2000114)2.62038457
161negative regulation of smooth muscle cell differentiation (GO:0051151)2.61228702
162porphyrin-containing compound biosynthetic process (GO:0006779)2.60538222
163negative regulation of Rho protein signal transduction (GO:0035024)2.60355775
164Golgi to endosome transport (GO:0006895)2.55536729
165regulation of female gonad development (GO:2000194)2.54595531
166regulation of fibroblast apoptotic process (GO:2000269)2.54348420
167cAMP catabolic process (GO:0006198)2.54208531
168peptidyl-threonine dephosphorylation (GO:0035970)2.53835574
169tetrapyrrole biosynthetic process (GO:0033014)2.53335497
170negative regulation of TOR signaling (GO:0032007)2.53260416
171positive regulation of granulocyte differentiation (GO:0030854)2.52585538
172photoreceptor cell maintenance (GO:0045494)2.51571014
173protoporphyrinogen IX biosynthetic process (GO:0006782)2.50979859
174regulation of hexokinase activity (GO:1903299)2.50684006
175regulation of glucokinase activity (GO:0033131)2.50684006
176recombinational repair (GO:0000725)2.49545641
177protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.48829122
178seminiferous tubule development (GO:0072520)2.48796629
179negative regulation of execution phase of apoptosis (GO:1900118)2.48190342
180phosphatidylethanolamine metabolic process (GO:0046337)2.47267951
181double-strand break repair via homologous recombination (GO:0000724)2.46594811
182histone H3-K9 modification (GO:0061647)2.45592503
183mitotic cell cycle arrest (GO:0071850)2.44996702
184histone demethylation (GO:0016577)2.44682738
185regulation of protein polyubiquitination (GO:1902914)2.43994930
186cytoplasmic mRNA processing body assembly (GO:0033962)2.43365123
187reciprocal DNA recombination (GO:0035825)2.42797255
188reciprocal meiotic recombination (GO:0007131)2.42797255
189phosphatidylethanolamine biosynthetic process (GO:0006646)2.42640659
190TOR signaling (GO:0031929)2.42144408
191regulation of action potential (GO:0098900)2.42018214
192peptidyl-lysine methylation (GO:0018022)2.41937185
193histone lysine demethylation (GO:0070076)2.41363683
194early endosome to late endosome transport (GO:0045022)2.40737709
195organelle membrane fusion (GO:0090174)2.40180996
196spinal cord motor neuron differentiation (GO:0021522)2.39954350
197meiotic cell cycle (GO:0051321)2.39720239

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.54602337
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.83980187
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.99294076
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.55335623
5ZNF274_21170338_ChIP-Seq_K562_Hela3.48410724
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.39255196
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.34125886
8IGF1R_20145208_ChIP-Seq_DFB_Human3.11498665
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.07605731
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.02908013
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.88849052
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.85568714
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.84257071
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.84233215
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.81446824
16VDR_22108803_ChIP-Seq_LS180_Human2.73708503
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.72083267
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65431860
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.62193096
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.60303282
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.55296699
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.51664993
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.49063230
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42744231
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.40509432
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.39702843
27NANOG_18555785_ChIP-Seq_MESCs_Mouse2.33653610
28FLI1_27457419_Chip-Seq_LIVER_Mouse2.31725257
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.28327217
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24021426
31AR_21909140_ChIP-Seq_LNCAP_Human2.22003278
32VDR_23849224_ChIP-Seq_CD4+_Human2.14984021
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12993593
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.12705842
35ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12664354
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.06701140
37GBX2_23144817_ChIP-Seq_PC3_Human2.04389500
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.04281488
39MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00588670
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95439513
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.93971960
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.93758170
43TAF15_26573619_Chip-Seq_HEK293_Human1.93426957
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.93299666
45GABP_19822575_ChIP-Seq_HepG2_Human1.92126958
46EWS_26573619_Chip-Seq_HEK293_Human1.91601274
47XRN2_22483619_ChIP-Seq_HELA_Human1.91120337
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89538610
49GATA1_22025678_ChIP-Seq_K562_Human1.87027935
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.86041388
51ER_23166858_ChIP-Seq_MCF-7_Human1.84297275
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81228004
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81191183
54P300_19829295_ChIP-Seq_ESCs_Human1.80724784
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80253187
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79902730
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79106841
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78682721
59STAT3_23295773_ChIP-Seq_U87_Human1.78357768
60NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.78243785
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77850637
62FUS_26573619_Chip-Seq_HEK293_Human1.77107433
63FOXP3_21729870_ChIP-Seq_TREG_Human1.75571140
64DCP1A_22483619_ChIP-Seq_HELA_Human1.74640653
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.69821462
66KDM5A_27292631_Chip-Seq_BREAST_Human1.67909087
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67720824
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.66080332
69TCF4_23295773_ChIP-Seq_U87_Human1.65821029
70SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.65587188
71HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.64431898
72EZH2_22144423_ChIP-Seq_EOC_Human1.62987950
73KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.56690128
74KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.56690128
75KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.56690128
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55672918
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.55090395
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.54713163
79SMAD4_21799915_ChIP-Seq_A2780_Human1.53834536
80SALL1_21062744_ChIP-ChIP_HESCs_Human1.53592558
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53272248
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.52736693
83* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51852821
84E2F1_21310950_ChIP-Seq_MCF-7_Human1.50894979
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49505767
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.48727655
87TTF2_22483619_ChIP-Seq_HELA_Human1.47411308
88NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.46770388
89STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.44894164
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.44288085
91SRF_21415370_ChIP-Seq_HL-1_Mouse1.43917190
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43913962
93CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41200902
94CBP_20019798_ChIP-Seq_JUKART_Human1.41192374
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41192374
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41042797
97RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39517738
98* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39224354
99KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39143403
100FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38127591
101TP53_16413492_ChIP-PET_HCT116_Human1.36564086
102POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36479607
103TP53_22573176_ChIP-Seq_HFKS_Human1.36013534
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35386804
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35386804
106NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.34824750
107TP63_19390658_ChIP-ChIP_HaCaT_Human1.34316402
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32815718
109AR_25329375_ChIP-Seq_VCAP_Human1.32623383
110MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31862498
111SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30965456
112NANOG_21062744_ChIP-ChIP_HESCs_Human1.30680142
113PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30382919
114KAP1_22055183_ChIP-Seq_ESCs_Mouse1.28416942
115OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27521546
116CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27353727
117BCAT_22108803_ChIP-Seq_LS180_Human1.27007008
118PRDM14_20953172_ChIP-Seq_ESCs_Human1.26802833
119ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25952872
120* CIITA_25753668_ChIP-Seq_RAJI_Human1.25518814
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.23821601
122TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22394481
123ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22387073
124NFE2_27457419_Chip-Seq_LIVER_Mouse1.21294869
125* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21174923
126KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20598000
127CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20491630
128KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.20171651
129TCF3_18692474_ChIP-Seq_MEFs_Mouse1.18973143
130CRX_20693478_ChIP-Seq_RETINA_Mouse1.18148454
131ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.17691997
132NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17584966
133NANOG_18555785_Chip-Seq_ESCs_Mouse1.16023235
134TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15358303
135EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14993633
136RUNX2_22187159_ChIP-Seq_PCA_Human1.14605430
137SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13471440
138PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12913565
139BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12911304
140SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12067253
141IRF8_22096565_ChIP-ChIP_GC-B_Human1.11714933
142ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11468812
143CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09804314
144CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.09645012
145MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09485134
146GATA3_26560356_Chip-Seq_TH2_Human1.09069227
147GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08894891
148SMAD3_21741376_ChIP-Seq_EPCs_Human1.08749072
149NANOG_19829295_ChIP-Seq_ESCs_Human1.08726523
150SOX2_19829295_ChIP-Seq_ESCs_Human1.08726523
151TCF4_22108803_ChIP-Seq_LS180_Human1.08629942
152SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08545397
153FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08061304
154ZNF263_19887448_ChIP-Seq_K562_Human1.07574666
155ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07231101
156CDX2_22108803_ChIP-Seq_LS180_Human1.06923835
157TCF3_18692474_ChIP-Seq_MESCs_Mouse1.05169432
158TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04891414
159DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04780061
160HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04647949
161SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04233370
162OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03694023
163TFEB_21752829_ChIP-Seq_HELA_Human1.03613291
164CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03501449
165FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03322777
166KAP1_27257070_Chip-Seq_ESCs_Mouse1.02916511
167NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02674806
168NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02674806
169EGR1_19374776_ChIP-ChIP_THP-1_Human1.02266452
170E2F1_18555785_Chip-Seq_ESCs_Mouse1.02184550
171SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02071889
172IRF1_19129219_ChIP-ChIP_H3396_Human1.01732661
173POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.01603685
174EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01357437
175RUNX_20019798_ChIP-Seq_JUKART_Human1.00992599
176FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.00115383
177HOXB7_26014856_ChIP-Seq_BT474_Human1.00069250
178P53_22387025_ChIP-Seq_ESCs_Mouse1.00009702
179SOX2_18692474_ChIP-Seq_MEFs_Mouse0.99698516
180SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99378231
181ELK1_19687146_ChIP-ChIP_HELA_Human0.98892103
182ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97531396
183SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97318284
184CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97271993
185E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95556609
186CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94300303
187OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93581512
188KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93533013
189SOX2_18692474_ChIP-Seq_MESCs_Mouse0.93071509
190SMAD4_21741376_ChIP-Seq_EPCs_Human0.92983933
191EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91879689
192PPARA_22158963_ChIP-Seq_LIVER_Mouse0.90606132
193ELK1_22589737_ChIP-Seq_MCF10A_Human0.89539039
194SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89484534
195NOTCH1_21737748_ChIP-Seq_TLL_Human0.88980929

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.25928069
2MP0004147_increased_porphyrin_level5.45049183
3MP0003111_abnormal_nucleus_morphology4.67430597
4MP0003718_maternal_effect4.29116795
5MP0004957_abnormal_blastocyst_morpholog4.01735090
6MP0010094_abnormal_chromosome_stability3.81070451
7MP0008260_abnormal_autophagy3.76401607
8MP0003077_abnormal_cell_cycle3.49752994
9MP0001986_abnormal_taste_sensitivity3.19914577
10MP0008058_abnormal_DNA_repair3.09326107
11MP0009840_abnormal_foam_cell2.91645729
12MP0008057_abnormal_DNA_replication2.84412892
13MP0005083_abnormal_biliary_tract2.83892613
14MP0003123_paternal_imprinting2.45907435
15MP0008877_abnormal_DNA_methylation2.44679782
16MP0003806_abnormal_nucleotide_metabolis2.41715518
17MP0003950_abnormal_plasma_membrane2.41704411
18MP0004145_abnormal_muscle_electrophysio2.39089093
19MP0000569_abnormal_digit_pigmentation2.37696142
20MP0002009_preneoplasia2.33386587
21MP0003786_premature_aging2.29667064
22MP0008007_abnormal_cellular_replicative2.20739754
23MP0001730_embryonic_growth_arrest2.15608734
24MP0005451_abnormal_body_composition2.15525682
25MP0004142_abnormal_muscle_tone2.10277917
26MP0004130_abnormal_muscle_cell2.08174879
27MP0002837_dystrophic_cardiac_calcinosis2.07934388
28MP0005365_abnormal_bile_salt2.06360117
29MP0008932_abnormal_embryonic_tissue2.03567106
30MP0002138_abnormal_hepatobiliary_system2.03036645
31MP0002653_abnormal_ependyma_morphology2.02366154
32MP0005174_abnormal_tail_pigmentation1.93978025
33MP0000350_abnormal_cell_proliferation1.92061382
34MP0005380_embryogenesis_phenotype1.90348352
35MP0001672_abnormal_embryogenesis/_devel1.90348352
36MP0002139_abnormal_hepatobiliary_system1.89255367
37MP0005551_abnormal_eye_electrophysiolog1.86046390
38MP0005085_abnormal_gallbladder_physiolo1.80996368
39MP0005075_abnormal_melanosome_morpholog1.79175436
40MP0003787_abnormal_imprinting1.75792963
41MP0010307_abnormal_tumor_latency1.70565415
42MP0005395_other_phenotype1.69627298
43MP0005360_urolithiasis1.68618150
44MP0008775_abnormal_heart_ventricle1.67079476
45MP0004084_abnormal_cardiac_muscle1.66177377
46MP0004215_abnormal_myocardial_fiber1.63385155
47MP0000427_abnormal_hair_cycle1.61680964
48MP0003984_embryonic_growth_retardation1.61639079
49MP0002088_abnormal_embryonic_growth/wei1.60260674
50MP0000749_muscle_degeneration1.60143980
51MP0002210_abnormal_sex_determination1.54384366
52MP0003878_abnormal_ear_physiology1.52564160
53MP0005377_hearing/vestibular/ear_phenot1.52564160
54MP0002638_abnormal_pupillary_reflex1.50064117
55MP0006292_abnormal_olfactory_placode1.46485899
56MP0001661_extended_life_span1.46357952
57MP0004885_abnormal_endolymph1.45678535
58MP0001697_abnormal_embryo_size1.43658631
59MP0001984_abnormal_olfaction1.42441626
60MP0001501_abnormal_sleep_pattern1.41819792
61MP0004036_abnormal_muscle_relaxation1.40734684
62MP0003656_abnormal_erythrocyte_physiolo1.40711836
63MP0002080_prenatal_lethality1.38175341
64MP0001929_abnormal_gametogenesis1.32486007
65MP0001145_abnormal_male_reproductive1.32042972
66MP0004043_abnormal_pH_regulation1.29104864
67MP0002095_abnormal_skin_pigmentation1.29013780
68MP0004019_abnormal_vitamin_homeostasis1.28410160
69MP0000653_abnormal_sex_gland1.26800916
70MP0002085_abnormal_embryonic_tissue1.25321479
71MP0000372_irregular_coat_pigmentation1.24983195
72MP0005332_abnormal_amino_acid1.22665018
73MP0000383_abnormal_hair_follicle1.22153405
74MP0002086_abnormal_extraembryonic_tissu1.21432508
75MP0001188_hyperpigmentation1.20906156
76MP0004484_altered_response_of1.20567827
77MP0001764_abnormal_homeostasis1.18163618
78MP0002106_abnormal_muscle_physiology1.17173201
79MP0002332_abnormal_exercise_endurance1.16443024
80MP0000013_abnormal_adipose_tissue1.15680290
81MP0003567_abnormal_fetal_cardiomyocyte1.14855228
82MP0004808_abnormal_hematopoietic_stem1.14586951
83MP0003221_abnormal_cardiomyocyte_apopto1.13825143
84MP0002132_abnormal_respiratory_system1.13783940
85MP0000015_abnormal_ear_pigmentation1.13297479
86MP0000313_abnormal_cell_death1.11958093
87MP0003045_fibrosis1.10957666
88MP0003699_abnormal_female_reproductive1.09914802
89MP0005253_abnormal_eye_physiology1.09436400
90MP0002084_abnormal_developmental_patter1.08373901
91MP0003646_muscle_fatigue1.07467123
92MP0001119_abnormal_female_reproductive1.07465708
93MP0009672_abnormal_birth_weight1.02174204
94MP0005369_muscle_phenotype1.00338835
95MP0001542_abnormal_bone_strength1.00287315
96MP0006035_abnormal_mitochondrial_morpho0.99411460
97MP0000609_abnormal_liver_physiology0.97179052
98MP0003136_yellow_coat_color0.96987952
99MP0005620_abnormal_muscle_contractility0.96866569
100MP0003315_abnormal_perineum_morphology0.95723680
101MP0008875_abnormal_xenobiotic_pharmacok0.95416859
102MP0002396_abnormal_hematopoietic_system0.92579052
103MP0003186_abnormal_redox_activity0.92056382
104MP0003828_pulmonary_edema0.92024426
105MP0001545_abnormal_hematopoietic_system0.91831164
106MP0005397_hematopoietic_system_phenotyp0.91831164
107MP0002019_abnormal_tumor_incidence0.90452830
108MP0009333_abnormal_splenocyte_physiolog0.88633438
109MP0003195_calcinosis0.87995788
110MP0000358_abnormal_cell_content/0.87344180
111MP0010329_abnormal_lipoprotein_level0.87045023
112MP0005646_abnormal_pituitary_gland0.86931351
113MP0005319_abnormal_enzyme/_coenzyme0.86920437
114MP0005621_abnormal_cell_physiology0.86845853
115MP0001502_abnormal_circadian_rhythm0.85071390
116MP0005384_cellular_phenotype0.83832842
117MP0000230_abnormal_systemic_arterial0.83575171
118MP0004197_abnormal_fetal_growth/weight/0.82016021
119MP0005167_abnormal_blood-brain_barrier0.81800594
120MP0002161_abnormal_fertility/fecundity0.80673757
121MP0005389_reproductive_system_phenotype0.79971465
122MP0004924_abnormal_behavior0.78781858
123MP0005386_behavior/neurological_phenoty0.78781858
124MP0003119_abnormal_digestive_system0.78004512
125MP0001544_abnormal_cardiovascular_syste0.77735510
126MP0005385_cardiovascular_system_phenoty0.77735510
127MP0003252_abnormal_bile_duct0.77614287
128MP0005266_abnormal_metabolism0.76954907
129MP0006276_abnormal_autonomic_nervous0.76499727
130MP0001486_abnormal_startle_reflex0.75914096
131MP0004264_abnormal_extraembryonic_tissu0.75908068
132MP0002163_abnormal_gland_morphology0.75823080
133MP0002102_abnormal_ear_morphology0.75541262
134MP0000631_abnormal_neuroendocrine_gland0.75026975
135MP0008872_abnormal_physiological_respon0.74879569
136MP0003941_abnormal_skin_development0.74185391
137MP0003011_delayed_dark_adaptation0.74182019
138MP0003890_abnormal_embryonic-extraembry0.73941551
139MP0009697_abnormal_copulation0.73861665
140MP0002972_abnormal_cardiac_muscle0.73187794
141MP0003938_abnormal_ear_development0.72781359
142MP0000490_abnormal_crypts_of0.72034196
143MP0008789_abnormal_olfactory_epithelium0.70176254
144MP0001756_abnormal_urination0.69281480
145MP0009703_decreased_birth_body0.69175899
146MP0002160_abnormal_reproductive_system0.68812298
147MP0000598_abnormal_liver_morphology0.68488525
148MP0009780_abnormal_chondrocyte_physiolo0.67650340
149MP0006036_abnormal_mitochondrial_physio0.67311152
150MP0008995_early_reproductive_senescence0.66657851
151MP0003698_abnormal_male_reproductive0.66053028
152MP0002269_muscular_atrophy0.64880745
153MP0003172_abnormal_lysosome_physiology0.64678228
154MP0005310_abnormal_salivary_gland0.64454068
155MP0002272_abnormal_nervous_system0.63695250
156MP0001529_abnormal_vocalization0.63599596
157MP0010678_abnormal_skin_adnexa0.62834793
158MP0009745_abnormal_behavioral_response0.62352555
159MP0000647_abnormal_sebaceous_gland0.61678298
160MP0002229_neurodegeneration0.61449815
161MP0002067_abnormal_sensory_capabilities0.60676415
162MP0000627_abnormal_mammary_gland0.59998081
163MP0002127_abnormal_cardiovascular_syste0.59966241
164MP0005410_abnormal_fertilization0.59701863
165MP0003763_abnormal_thymus_physiology0.58955058
166MP0002111_abnormal_tail_morphology0.58893346
167MP0002108_abnormal_muscle_morphology0.58748681
168MP0001919_abnormal_reproductive_system0.56831642
169MP0001293_anophthalmia0.53899048
170MP0001727_abnormal_embryo_implantation0.53889751
171MP0003121_genomic_imprinting0.51873405

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.42369761
2Hyperglycinemia (HP:0002154)5.41750662
3Breast hypoplasia (HP:0003187)5.34824042
4Impulsivity (HP:0100710)5.03561198
5Hyperglycinuria (HP:0003108)4.61439606
6Cerebral hypomyelination (HP:0006808)4.18067880
7Abnormality of the heme biosynthetic pathway (HP:0010472)3.95586811
8Carpal bone hypoplasia (HP:0001498)3.92712759
9Fair hair (HP:0002286)3.90734038
10Abnormality of glycine metabolism (HP:0010895)3.86096450
11Abnormality of serine family amino acid metabolism (HP:0010894)3.86096450
12Abnormality of the renal cortex (HP:0011035)3.82718122
13Patellar aplasia (HP:0006443)3.81380644
14Pancreatic cysts (HP:0001737)3.73079585
15Gout (HP:0001997)3.71270492
16Hyperventilation (HP:0002883)3.70397826
17Poikilocytosis (HP:0004447)3.67677000
18Aplasia/Hypoplasia of the patella (HP:0006498)3.66854829
19Molar tooth sign on MRI (HP:0002419)3.55413276
20Abnormality of midbrain morphology (HP:0002418)3.55413276
21Rough bone trabeculation (HP:0100670)3.54140422
22Abnormality of the labia minora (HP:0012880)3.52504906
23Abnormality of the renal medulla (HP:0100957)3.45635393
24Nephronophthisis (HP:0000090)3.44570974
25Tubular atrophy (HP:0000092)3.32700020
26Abnormality of serum amino acid levels (HP:0003112)3.31477231
27Ureteral duplication (HP:0000073)3.27018865
28Premature ovarian failure (HP:0008209)3.22446760
29Abnormality of the anterior horn cell (HP:0006802)3.11723244
30Degeneration of anterior horn cells (HP:0002398)3.11723244
31Abnormal drinking behavior (HP:0030082)3.10170274
32Polydipsia (HP:0001959)3.10170274
33Secondary amenorrhea (HP:0000869)3.06700762
34Generalized hypopigmentation of hair (HP:0011358)3.03719692
35Calf muscle hypertrophy (HP:0008981)3.00634159
36Muscle hypertrophy of the lower extremities (HP:0008968)2.89842559
37Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.89343887
38Type II lissencephaly (HP:0007260)2.89090866
39Medial flaring of the eyebrow (HP:0010747)2.88645104
40Tetraplegia (HP:0002445)2.87030763
41Entropion (HP:0000621)2.86180476
42Absent radius (HP:0003974)2.84777900
43Chronic hepatic failure (HP:0100626)2.84340548
44Megaloblastic anemia (HP:0001889)2.74979038
45Protruding tongue (HP:0010808)2.74933802
46Aplasia/Hypoplasia involving the musculature (HP:0001460)2.73065587
47Microcytic anemia (HP:0001935)2.70594999
48Renal cortical cysts (HP:0000803)2.70321854
49Clumsiness (HP:0002312)2.68948683
50Papillary thyroid carcinoma (HP:0002895)2.68815359
51Tubulointerstitial nephritis (HP:0001970)2.67092248
52CNS hypomyelination (HP:0003429)2.66276396
53Absent forearm bone (HP:0003953)2.65830048
54Aplasia involving forearm bones (HP:0009822)2.65830048
55Death in infancy (HP:0001522)2.57560137
56Large for gestational age (HP:0001520)2.56216850
57Abnormal trabecular bone morphology (HP:0100671)2.55534448
58Abnormality of the umbilical cord (HP:0010881)2.54972494
59Widely spaced teeth (HP:0000687)2.54710511
60Gaze-evoked nystagmus (HP:0000640)2.53469778
61Cerebellar dysplasia (HP:0007033)2.53408834
62Facial hemangioma (HP:0000329)2.53408117
63Abnormal spermatogenesis (HP:0008669)2.50409971
64Prolonged neonatal jaundice (HP:0006579)2.48585226
65Shawl scrotum (HP:0000049)2.48388618
66Hematochezia (HP:0002573)2.46728335
67Multiple enchondromatosis (HP:0005701)2.45601132
68Stomach cancer (HP:0012126)2.45186602
69Oral leukoplakia (HP:0002745)2.42422364
70Chromosomal breakage induced by crosslinking agents (HP:0003221)2.40166527
71Hyperkalemia (HP:0002153)2.39972540
72Tongue fasciculations (HP:0001308)2.37844454
73Ependymoma (HP:0002888)2.37415952
74Oligodactyly (hands) (HP:0001180)2.36425551
75Attenuation of retinal blood vessels (HP:0007843)2.34590734
76Progressive inability to walk (HP:0002505)2.33585628
77Progressive muscle weakness (HP:0003323)2.33002744
78Delusions (HP:0000746)2.32637421
79Tubulointerstitial abnormality (HP:0001969)2.31909436
80True hermaphroditism (HP:0010459)2.31476372
81Hyperglycemia (HP:0003074)2.31138040
82Muscle fiber inclusion bodies (HP:0100299)2.30434177
83Azoospermia (HP:0000027)2.29927484
84Breast aplasia (HP:0100783)2.29468746
85Congenital stationary night blindness (HP:0007642)2.29036065
86Dysautonomia (HP:0002459)2.28641750
87Nemaline bodies (HP:0003798)2.28199536
88Albinism (HP:0001022)2.28166217
89Chromsome breakage (HP:0040012)2.27996516
90Personality changes (HP:0000751)2.27094168
91Abnormality of the preputium (HP:0100587)2.25669099
92Aplasia/Hypoplasia of the tibia (HP:0005772)2.24478287
93Capillary hemangiomas (HP:0005306)2.21853509
94Hypoplastic iliac wings (HP:0002866)2.20391232
95Anhidrosis (HP:0000970)2.19938077
96Sparse eyelashes (HP:0000653)2.19520357
97Abnormality of lateral ventricle (HP:0030047)2.19413375
98Muscle fibrillation (HP:0010546)2.16585560
99Oligodactyly (HP:0012165)2.16451139
100Abolished electroretinogram (ERG) (HP:0000550)2.15983848
101Hypochromic anemia (HP:0001931)2.15884491
102Sparse lateral eyebrow (HP:0005338)2.15588140
103Spinal muscular atrophy (HP:0007269)2.15200647
104Meckel diverticulum (HP:0002245)2.15125358
105Abnormality of pyrimidine metabolism (HP:0004353)2.14469651
106Inability to walk (HP:0002540)2.14179569
107Congenital hepatic fibrosis (HP:0002612)2.13274007
108Aplasia/Hypoplasia of the breasts (HP:0010311)2.13058363
109Pustule (HP:0200039)2.12387343
110Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.11149677
111Global brain atrophy (HP:0002283)2.10997359
112Abnormal rod and cone electroretinograms (HP:0008323)2.08623517
113Areflexia of lower limbs (HP:0002522)2.08420868
114Bone marrow hypocellularity (HP:0005528)2.08023327
115Truncal obesity (HP:0001956)2.07808432
116Abnormality of chromosome stability (HP:0003220)2.06474717
117Spastic paraparesis (HP:0002313)2.05413178
118Atrophy/Degeneration involving motor neurons (HP:0007373)2.05016311
119Hypobetalipoproteinemia (HP:0003563)2.04660758
120Volvulus (HP:0002580)2.02537343
121Bile duct proliferation (HP:0001408)2.01746276
122Abnormal biliary tract physiology (HP:0012439)2.01746276
123Neoplasm of the tracheobronchial system (HP:0100552)2.00472327
124Abnormality of the ileum (HP:0001549)2.00260540
125Atrioventricular block (HP:0001678)1.98795961
126Polyuria (HP:0000103)1.98533085
127Microretrognathia (HP:0000308)1.98478072
128Rhabdomyosarcoma (HP:0002859)1.98357075
129Pancreatic fibrosis (HP:0100732)1.97784162
130Absent hand (HP:0004050)1.94827670
131Male infertility (HP:0003251)1.94474869
132Abnormal neuron morphology (HP:0012757)1.94321202
133Abnormality of the motor neurons (HP:0002450)1.94321202
134Abnormality of the pons (HP:0007361)1.93587932
135Acute myeloid leukemia (HP:0004808)1.92645434
136Congenital primary aphakia (HP:0007707)1.92635144
137Horseshoe kidney (HP:0000085)1.90397522
138Broad-based gait (HP:0002136)1.90060494
139Poor coordination (HP:0002370)1.89332764
140Abnormal biliary tract morphology (HP:0012440)1.89042044
141Abnormality of alanine metabolism (HP:0010916)1.86274777
142Hyperalaninemia (HP:0003348)1.86274777
143Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86274777
144Nephrogenic diabetes insipidus (HP:0009806)1.85374810
145Abnormalities of placenta or umbilical cord (HP:0001194)1.85353512
146Alveolar cell carcinoma (HP:0006519)1.84918983
147Febrile seizures (HP:0002373)1.83870698
148Hyperuricemia (HP:0002149)1.83740900
149Increased purine levels (HP:0004368)1.83740900
150Abnormality of sulfur amino acid metabolism (HP:0004339)1.83071304
151Gait imbalance (HP:0002141)1.81836564
152Hypochromic microcytic anemia (HP:0004840)1.80910420
153Abnormality of the distal phalanges of the toes (HP:0010182)1.80500218
154Subaortic stenosis (HP:0001682)1.79544687
155Abnormality of the left ventricular outflow tract (HP:0011103)1.79544687
156Abnormality of monocarboxylic acid metabolism (HP:0010996)1.79165440
157Rimmed vacuoles (HP:0003805)1.78282227
158Aplasia/Hypoplasia of the uvula (HP:0010293)1.77285278
159Abnormality of methionine metabolism (HP:0010901)1.76837776
160Glioma (HP:0009733)1.76060169
161Irritability (HP:0000737)1.75439105
162Lethargy (HP:0001254)1.75061973
163Stomatitis (HP:0010280)1.74926351
164Hypoplasia of the capital femoral epiphysis (HP:0003090)1.74722551
165Cystic liver disease (HP:0006706)1.74659741
166Aplasia/hypoplasia of the humerus (HP:0006507)1.74158227
167Abnormality of the renal collecting system (HP:0004742)1.73657812
168Aplasia/Hypoplasia of the earlobes (HP:0009906)1.73410220
169Squamous cell carcinoma (HP:0002860)1.72896118
170CNS demyelination (HP:0007305)1.72801798
171Tubulointerstitial fibrosis (HP:0005576)1.72617336
172Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72464498
173Ectopic kidney (HP:0000086)1.72211349
174Stillbirth (HP:0003826)1.71982367
175Thyroiditis (HP:0100646)1.71290819
176Short tibia (HP:0005736)1.70007768
177Hypoplasia of the fovea (HP:0007750)1.69826476
178Aplasia/Hypoplasia of the fovea (HP:0008060)1.69826476
179Abnormality of DNA repair (HP:0003254)1.69038031
180Duplicated collecting system (HP:0000081)1.68401355
181Genetic anticipation (HP:0003743)1.66970887
182Biliary tract neoplasm (HP:0100574)1.66836074
183Abnormality of the aortic arch (HP:0012303)1.66246629
184Aplasia/Hypoplasia of the tongue (HP:0010295)1.66183095
185Exercise-induced muscle cramps (HP:0003710)1.65551651
186Thyroid carcinoma (HP:0002890)1.65459061
187Abnormality of the nasal septum (HP:0000419)1.64356892
188Supernumerary spleens (HP:0009799)1.63049586
189Drooling (HP:0002307)1.62738380
190Abnormal urine output (HP:0012590)1.62656645
191Toxemia of pregnancy (HP:0100603)1.62616827
192Absent speech (HP:0001344)1.62173070
193Paralysis (HP:0003470)1.58562454

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.40804232
2FRK4.38839205
3WEE14.38663716
4AKT34.23311574
5TAOK33.79947191
6TSSK63.27723209
7NEK23.12742015
8EIF2AK13.10863287
9PLK43.04141503
10EPHA22.90956033
11TTK2.74644009
12OBSCN2.68483404
13BMPR1B2.44723179
14ACVR1B2.27042042
15PLK12.19732177
16PLK32.12918466
17NEK12.09809537
18BRSK22.08541628
19SRPK11.96190022
20MKNK21.85696901
21BRAF1.81420807
22STK38L1.80914350
23ARAF1.77333015
24MAP4K21.73309155
25ZAK1.73130489
26DYRK31.71358273
27STK161.71357579
28IRAK31.68733315
29NUAK11.68542503
30WNK11.68044059
31CDC71.65171104
32TXK1.64968726
33CHEK21.55321997
34BRSK11.52065162
35ADRBK21.44978183
36NLK1.44228545
37TRPM71.44182203
38STK391.43372105
39EIF2AK31.40006663
40LATS21.38829668
41PDK31.36690267
42PDK41.36690267
43WNK41.31013744
44CAMKK21.30707904
45CDK71.29789037
46PIK3CG1.29590659
47AURKB1.28557033
48CDK121.25225336
49MAP2K61.22952553
50ERBB31.21988614
51CAMK1D1.21772737
52STK31.20265891
53MKNK11.17810687
54AURKA1.16447876
55MAP3K41.16421583
56PHKG11.16231171
57PHKG21.16231171
58PTK2B1.16147562
59CAMK1G1.15957684
60PDK21.13900901
61KIT1.10750339
62GRK11.10522034
63NME21.10361567
64TEC1.09806364
65PINK11.09351323
66CDK41.04647987
67CHUK1.01524576
68CHEK11.01435410
69MAP3K71.00185808
70CDK80.97737292
71STK240.97557802
72PRKAA20.97499226
73TESK20.97271633
74OXSR10.96559875
75TLK10.96145996
76CCNB10.95960563
77FLT30.94386894
78PNCK0.94108480
79IRAK10.91332676
80PIM20.90865038
81PRKCI0.90421026
82ATR0.88908017
83PAK30.88504712
84RPS6KA40.86501942
85MAP3K80.85561039
86TNIK0.84683591
87ALK0.84378375
88CASK0.83463844
89PIM10.81516138
90CDK20.78276922
91MAP3K90.77221813
92MELK0.75258585
93STK110.74679132
94TGFBR10.74421665
95STK40.73324230
96TNK20.73231732
97MUSK0.72968587
98ITK0.72646897
99INSRR0.72564936
100BCKDK0.71196988
101PIK3CA0.68452562
102CAMK40.68163987
103VRK10.66899243
104IKBKE0.66100150
105DAPK20.65608367
106TAF10.65415171
107MAPK110.63535728
108ERBB40.62526373
109KSR10.62416983
110HIPK20.62065621
111EIF2AK20.60329589
112PRKCE0.60107203
113CAMK10.60089139
114DYRK1B0.59116177
115CDK10.58433564
116SGK2230.57079060
117SGK4940.57079060
118ATM0.56488679
119DYRK1A0.56480351
120SGK30.56268994
121MST40.56259602
122RAF10.54334928
123STK100.54330886
124RPS6KB20.53382506
125MAP2K30.53093991
126PRKAA10.51963628
127PAK10.51317303
128CDK30.51266685
129DYRK20.50951764
130CSNK1D0.50933679
131MAPK130.50638899
132CSNK2A10.50287053
133CSNK1E0.47896941
134CDK90.47591569
135TAOK20.46151594
136CSNK2A20.45903056
137SGK10.45098019
138SYK0.44271012
139MTOR0.43694721
140MAP2K10.41923214
141PLK20.41281471
142PRKCQ0.41210478
143MAPK120.38827645
144NEK60.38349192
145MAP3K30.37978644
146MET0.37610179
147CSNK1G10.37280922
148RPS6KA60.36309954
149MAP3K50.35848570
150YES10.35539862
151SGK20.35302509
152MAPK70.35241936
153ADRBK10.35219490
154TAOK10.33114220
155CDK60.31562334
156ABL20.31236382
157MAPKAPK30.30904489
158AKT20.29670040
159LATS10.27698237
160MAPK100.27082645
161CSNK1G30.27009016
162BRD40.26836903
163WNK30.23983548
164RPS6KA50.22446889
165FGFR40.20759311
166BMPR20.20634753
167MAP3K130.20418056
168IKBKB0.20206316
169CSNK1A10.19916388
170GSK3B0.19549417
171STK380.17935642
172MARK30.17906493
173MAPK140.15356830

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.10890279
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.96864631
3RNA polymerase_Homo sapiens_hsa030203.92402483
4RNA transport_Homo sapiens_hsa030133.08318865
5Dorso-ventral axis formation_Homo sapiens_hsa043203.03000259
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.83004541
7Proteasome_Homo sapiens_hsa030502.75751842
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.49824942
9Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.41063211
10Cell cycle_Homo sapiens_hsa041102.38073061
11Folate biosynthesis_Homo sapiens_hsa007902.32959040
12Spliceosome_Homo sapiens_hsa030402.25296160
13DNA replication_Homo sapiens_hsa030302.25092358
14Basal transcription factors_Homo sapiens_hsa030222.23248808
15Mismatch repair_Homo sapiens_hsa034302.21785313
16Pyrimidine metabolism_Homo sapiens_hsa002402.17591950
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.16771997
18Homologous recombination_Homo sapiens_hsa034402.13270360
19Ether lipid metabolism_Homo sapiens_hsa005651.98539335
20Phototransduction_Homo sapiens_hsa047441.94868687
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.94262183
22ABC transporters_Homo sapiens_hsa020101.88302362
23* Regulation of autophagy_Homo sapiens_hsa041401.87165122
24Nucleotide excision repair_Homo sapiens_hsa034201.87133925
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.83980911
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79787784
27Base excision repair_Homo sapiens_hsa034101.79538166
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.79017794
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.76322707
30Fanconi anemia pathway_Homo sapiens_hsa034601.71751311
31Pentose phosphate pathway_Homo sapiens_hsa000301.71339343
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.55502209
33p53 signaling pathway_Homo sapiens_hsa041151.52479362
34One carbon pool by folate_Homo sapiens_hsa006701.51199521
35Biosynthesis of amino acids_Homo sapiens_hsa012301.45649115
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42123024
37Selenocompound metabolism_Homo sapiens_hsa004501.40467092
38Purine metabolism_Homo sapiens_hsa002301.35328068
39Glycerophospholipid metabolism_Homo sapiens_hsa005641.34420295
40Vitamin digestion and absorption_Homo sapiens_hsa049771.30509334
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25903966
42RNA degradation_Homo sapiens_hsa030181.23003192
43mRNA surveillance pathway_Homo sapiens_hsa030151.22184449
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21570968
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.21028847
46Inositol phosphate metabolism_Homo sapiens_hsa005621.18156118
47Fructose and mannose metabolism_Homo sapiens_hsa000511.16304461
48Caffeine metabolism_Homo sapiens_hsa002321.13592306
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08614421
50Oocyte meiosis_Homo sapiens_hsa041141.04896001
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02303796
52Ovarian steroidogenesis_Homo sapiens_hsa049131.01341304
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99540272
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99426011
55Epstein-Barr virus infection_Homo sapiens_hsa051690.97838088
56Jak-STAT signaling pathway_Homo sapiens_hsa046300.95855588
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.95226535
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94366833
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93851007
60Nicotine addiction_Homo sapiens_hsa050330.93689234
61Non-homologous end-joining_Homo sapiens_hsa034500.92856580
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92134431
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91361130
64Circadian rhythm_Homo sapiens_hsa047100.89994814
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88023262
66Insulin resistance_Homo sapiens_hsa049310.85977374
67Carbon metabolism_Homo sapiens_hsa012000.85939778
68Calcium signaling pathway_Homo sapiens_hsa040200.85030573
69Long-term depression_Homo sapiens_hsa047300.83962656
70Sulfur relay system_Homo sapiens_hsa041220.82830063
71Oxytocin signaling pathway_Homo sapiens_hsa049210.82431695
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81979712
73Arginine biosynthesis_Homo sapiens_hsa002200.80119146
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.80106958
75T cell receptor signaling pathway_Homo sapiens_hsa046600.79433704
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79346104
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78704984
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77812483
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76229133
80Type II diabetes mellitus_Homo sapiens_hsa049300.75983652
81Histidine metabolism_Homo sapiens_hsa003400.75884701
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73395079
83Insulin secretion_Homo sapiens_hsa049110.72618159
84Ribosome_Homo sapiens_hsa030100.72324536
85Asthma_Homo sapiens_hsa053100.71370142
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.69309382
87MAPK signaling pathway_Homo sapiens_hsa040100.69209395
88beta-Alanine metabolism_Homo sapiens_hsa004100.67210723
89Olfactory transduction_Homo sapiens_hsa047400.66286793
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65949891
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64243517
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64001554
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63583120
94Butanoate metabolism_Homo sapiens_hsa006500.63476064
95Taste transduction_Homo sapiens_hsa047420.63447334
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60656259
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.60441876
98Retinol metabolism_Homo sapiens_hsa008300.59181712
99Glutathione metabolism_Homo sapiens_hsa004800.59093934
100Arginine and proline metabolism_Homo sapiens_hsa003300.54760214
101Primary immunodeficiency_Homo sapiens_hsa053400.54737360
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54349197
103TGF-beta signaling pathway_Homo sapiens_hsa043500.53809026
104Metabolic pathways_Homo sapiens_hsa011000.53350073
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53340465
106Morphine addiction_Homo sapiens_hsa050320.53209200
107Peroxisome_Homo sapiens_hsa041460.52378502
108Choline metabolism in cancer_Homo sapiens_hsa052310.51766484
109Tryptophan metabolism_Homo sapiens_hsa003800.51687908
110Complement and coagulation cascades_Homo sapiens_hsa046100.50581847
111Nitrogen metabolism_Homo sapiens_hsa009100.49048041
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48044624
113Hematopoietic cell lineage_Homo sapiens_hsa046400.46875535
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46844565
115Glutamatergic synapse_Homo sapiens_hsa047240.46575844
116Circadian entrainment_Homo sapiens_hsa047130.46400602
117Glucagon signaling pathway_Homo sapiens_hsa049220.46248315
118Fatty acid degradation_Homo sapiens_hsa000710.46040898
119mTOR signaling pathway_Homo sapiens_hsa041500.45770536
120Galactose metabolism_Homo sapiens_hsa000520.44128339
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.44110992
122Salivary secretion_Homo sapiens_hsa049700.43646559
123Collecting duct acid secretion_Homo sapiens_hsa049660.43069802
124Serotonergic synapse_Homo sapiens_hsa047260.42909214
125Ras signaling pathway_Homo sapiens_hsa040140.42662854
126Glycerolipid metabolism_Homo sapiens_hsa005610.42281495
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.42218382
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39839360
129Renal cell carcinoma_Homo sapiens_hsa052110.39189335
130Antigen processing and presentation_Homo sapiens_hsa046120.36188070
131cAMP signaling pathway_Homo sapiens_hsa040240.35896696
132Prolactin signaling pathway_Homo sapiens_hsa049170.35751872
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34781177
134Acute myeloid leukemia_Homo sapiens_hsa052210.34687053
135Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34447070
136Herpes simplex infection_Homo sapiens_hsa051680.33758026
137Fatty acid metabolism_Homo sapiens_hsa012120.32201764
138GnRH signaling pathway_Homo sapiens_hsa049120.32048092
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31948820
140FoxO signaling pathway_Homo sapiens_hsa040680.31045555
141Steroid hormone biosynthesis_Homo sapiens_hsa001400.30800664
142Linoleic acid metabolism_Homo sapiens_hsa005910.30790699
143Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30628000
144Platelet activation_Homo sapiens_hsa046110.29780972
145Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27184021
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26922710
147Lysosome_Homo sapiens_hsa041420.22658377
148Arachidonic acid metabolism_Homo sapiens_hsa005900.21994658
149Viral carcinogenesis_Homo sapiens_hsa052030.21334006
150alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20076002
151Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17788626
152Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.16864781
153Lysine degradation_Homo sapiens_hsa003100.16720972
154PPAR signaling pathway_Homo sapiens_hsa033200.15106684
155Steroid biosynthesis_Homo sapiens_hsa001000.14749266
156Staphylococcus aureus infection_Homo sapiens_hsa051500.11667026
157Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.11471793
158Chemical carcinogenesis_Homo sapiens_hsa052040.11449714
159Phenylalanine metabolism_Homo sapiens_hsa003600.10758940
160Prion diseases_Homo sapiens_hsa050200.10178735
161Fat digestion and absorption_Homo sapiens_hsa049750.09318201
162AMPK signaling pathway_Homo sapiens_hsa041520.07411946
163Propanoate metabolism_Homo sapiens_hsa006400.07041449
164Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.06726849

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