ATF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to lipoprotein particle (GO:0055094)8.84634305
2positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)7.62511873
3spindle assembly involved in mitosis (GO:0090307)7.07040829
4regulation of syncytium formation by plasma membrane fusion (GO:0060142)5.95720506
5prostate gland growth (GO:0060736)5.88049107
6negative regulation of acute inflammatory response (GO:0002674)5.72779109
7microtubule cytoskeleton organization involved in mitosis (GO:1902850)5.51657348
8positive regulation of inositol phosphate biosynthetic process (GO:0060732)5.45799025
9gland morphogenesis (GO:0022612)5.22048439
10anterior/posterior axis specification, embryo (GO:0008595)5.03143121
11regulation of tight junction assembly (GO:2000810)4.97781457
12centrosome duplication (GO:0051298)4.80166650
13COPI coating of Golgi vesicle (GO:0048205)4.66113522
14Golgi transport vesicle coating (GO:0048200)4.66113522
15cell differentiation involved in embryonic placenta development (GO:0060706)4.62292403
16negative regulation of Rho protein signal transduction (GO:0035024)4.57330092
17inner cell mass cell proliferation (GO:0001833)4.53538147
18regulation of sequestering of triglyceride (GO:0010889)4.51357294
19regulation of cell proliferation involved in kidney development (GO:1901722)4.49496888
20regulation of energy homeostasis (GO:2000505)4.44899578
21regulation of inositol phosphate biosynthetic process (GO:0010919)4.44016891
22negative regulation of lipid storage (GO:0010888)4.28834176
23white fat cell differentiation (GO:0050872)4.20448236
24cellular response to lithium ion (GO:0071285)4.16975907
25monocyte differentiation (GO:0030224)4.12728571
26mitochondrial fusion (GO:0008053)4.08217618
27lipoprotein transport (GO:0042953)4.00296190
28positive regulation of oligodendrocyte differentiation (GO:0048714)3.99935989
29positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.97495165
30negative regulation of telomerase activity (GO:0051974)3.97104152
31response to caffeine (GO:0031000)3.83235596
32negative regulation of TOR signaling (GO:0032007)3.76826683
33myelination in peripheral nervous system (GO:0022011)3.72679557
34peripheral nervous system axon ensheathment (GO:0032292)3.72679557
35negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.68815929
36regulation of receptor biosynthetic process (GO:0010869)3.65617974
37mitochondrion morphogenesis (GO:0070584)3.65369828
38* activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.63541115
39cell adhesion mediated by integrin (GO:0033627)3.42987629
40maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.42898897
41* positive regulation of nuclease activity (GO:0032075)3.41370021
42serine family amino acid catabolic process (GO:0009071)3.37061608
43protein carboxylation (GO:0018214)3.32790810
44peptidyl-glutamic acid carboxylation (GO:0017187)3.32790810
45peroxisome fission (GO:0016559)3.32373844
46lymphangiogenesis (GO:0001946)3.29304495
47COPII vesicle coating (GO:0048208)3.27850784
48response to methylmercury (GO:0051597)3.27665806
49* endoplasmic reticulum unfolded protein response (GO:0030968)3.21303150
50erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.20126251
51L-phenylalanine catabolic process (GO:0006559)3.20126251
523-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.15058732
53purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.15058732
54lysine metabolic process (GO:0006553)3.14501645
55lysine catabolic process (GO:0006554)3.14501645
56wound healing, spreading of epidermal cells (GO:0035313)3.12554169
57valine metabolic process (GO:0006573)3.11634536
58* ER-nucleus signaling pathway (GO:0006984)3.10586867
59* cellular response to unfolded protein (GO:0034620)3.10315269
60fatty acid transmembrane transport (GO:1902001)3.08831896
61macroautophagy (GO:0016236)3.08494516
62response to vitamin A (GO:0033189)3.08245690
63negative regulation of kidney development (GO:0090185)3.07884280
64phospholipid homeostasis (GO:0055091)3.06030278
65iron ion import (GO:0097286)3.05588150
66cellular response to arsenic-containing substance (GO:0071243)3.05480722
67* regulation of nuclease activity (GO:0032069)3.05112805
68complement activation, alternative pathway (GO:0006957)3.04973723
69dicarboxylic acid biosynthetic process (GO:0043650)3.04698586
702-oxoglutarate metabolic process (GO:0006103)3.04646017
71glycerol ether metabolic process (GO:0006662)3.02811431
72retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.01742144
73synapsis (GO:0007129)3.01461770
74carnitine shuttle (GO:0006853)3.00766299
75regulation of cholesterol homeostasis (GO:2000188)2.99997812
76positive regulation of fatty acid beta-oxidation (GO:0032000)2.99454256
77regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.97736213
78germinal center formation (GO:0002467)2.97219945
79alpha-linolenic acid metabolic process (GO:0036109)2.96040284
80TOR signaling (GO:0031929)2.95636755
81L-phenylalanine metabolic process (GO:0006558)2.93399380
82erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.93399380
83positive regulation of glomerulus development (GO:0090193)2.92691979
84T cell lineage commitment (GO:0002360)2.91401623
85positive regulation of alcohol biosynthetic process (GO:1902932)2.90939028
86cytoplasmic mRNA processing body assembly (GO:0033962)2.89118106
87mannose metabolic process (GO:0006013)2.88121594
884-hydroxyproline metabolic process (GO:0019471)2.85408919
89embryonic camera-type eye development (GO:0031076)2.85209054
90regulation of receptor binding (GO:1900120)2.83323582
91regulation of telomerase activity (GO:0051972)2.83002084
92* cellular response to topologically incorrect protein (GO:0035967)2.82943783
93positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.82810574
94lung-associated mesenchyme development (GO:0060484)2.80830530
95protein targeting to Golgi (GO:0000042)2.80069137
96sulfur amino acid catabolic process (GO:0000098)2.79482174
97artery development (GO:0060840)2.79436073
98negative regulation of DNA biosynthetic process (GO:2000279)2.78248460
99triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.78182026
100apoptotic cell clearance (GO:0043277)2.77902574
101protein retention in ER lumen (GO:0006621)2.77769997
102protein kinase C signaling (GO:0070528)2.77379441
103tyrosine metabolic process (GO:0006570)2.76728587
104regulation of fatty acid beta-oxidation (GO:0031998)2.76119501
105regulation of glial cell proliferation (GO:0060251)2.75487337
106ether metabolic process (GO:0018904)2.75299587
107calcium-mediated signaling using intracellular calcium source (GO:0035584)2.75018381
108regulation of alkaline phosphatase activity (GO:0010692)2.74495204
109fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.73831630
110regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.73515706
111mitochondrial respiratory chain complex I assembly (GO:0032981)2.70003271
112NADH dehydrogenase complex assembly (GO:0010257)2.70003271
113mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.70003271
114regulation of protein activation cascade (GO:2000257)2.69812407
115aromatic amino acid family catabolic process (GO:0009074)2.68930128
116estrogen metabolic process (GO:0008210)2.68628866
117retrograde transport, vesicle recycling within Golgi (GO:0000301)2.68512738
118positive regulation of macroautophagy (GO:0016239)2.67624704
119CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.67531261
120ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.67489377
121glycine metabolic process (GO:0006544)2.67273195
122kynurenine metabolic process (GO:0070189)2.65913109
123vesicle coating (GO:0006901)2.65397154
124interleukin-6-mediated signaling pathway (GO:0070102)2.65192090
125regulation of response to interferon-gamma (GO:0060330)2.64947861
126homocysteine metabolic process (GO:0050667)2.61836466
127negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.61421905
128definitive hemopoiesis (GO:0060216)2.60546590
129relaxation of cardiac muscle (GO:0055119)2.59958001
130mammary gland epithelial cell proliferation (GO:0033598)2.59407332
131positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.59254237
132high-density lipoprotein particle remodeling (GO:0034375)2.59194951
133regulation of complement activation (GO:0030449)2.58814572
134regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.58110959
135establishment of protein localization to Golgi (GO:0072600)2.58038937
136cysteine metabolic process (GO:0006534)2.57441034
137* response to endoplasmic reticulum stress (GO:0034976)2.57408940
138positive regulation of p38MAPK cascade (GO:1900745)2.57078755
139interkinetic nuclear migration (GO:0022027)2.56654468
140platelet-derived growth factor receptor signaling pathway (GO:0048008)2.56018905
141detection of molecule of bacterial origin (GO:0032490)2.55680279
142regulation of fatty acid oxidation (GO:0046320)2.55666946
143endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.55563601
144exocrine pancreas development (GO:0031017)2.54950906
145positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.54303506
146antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.53757256
147negative regulation of systemic arterial blood pressure (GO:0003085)2.53485442
148regulation of triglyceride catabolic process (GO:0010896)2.53421961
149positive regulation of mitochondrial fission (GO:0090141)2.53119912
150negative regulation of complement activation (GO:0045916)2.53086720
151positive regulation of histone deacetylation (GO:0031065)2.52696348
152positive regulation of fatty acid oxidation (GO:0046321)2.52379582
153reverse cholesterol transport (GO:0043691)2.52228561
154urea cycle (GO:0000050)2.52048112
155urea metabolic process (GO:0019627)2.52048112
156heme biosynthetic process (GO:0006783)2.51537834
157negative regulation of T-helper cell differentiation (GO:0045623)2.50695977
158negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.50695977
159ER overload response (GO:0006983)2.50528795
160cellular modified amino acid catabolic process (GO:0042219)2.49975594
161regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.49972106
162drug transmembrane transport (GO:0006855)2.49342657
163intestinal cholesterol absorption (GO:0030299)2.49152022
164negative regulation of fibrinolysis (GO:0051918)2.48879380
165negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.48772222
166blood vessel maturation (GO:0001955)2.47622725
167tryptophan metabolic process (GO:0006568)2.46894126
168positive regulation of glycolytic process (GO:0045821)2.46744962
169fatty acid beta-oxidation (GO:0006635)2.46283593
170tricarboxylic acid metabolic process (GO:0072350)2.45870971
171oxaloacetate metabolic process (GO:0006107)2.45780738
172plasma lipoprotein particle clearance (GO:0034381)2.45735499
173low-density lipoprotein particle clearance (GO:0034383)2.44399515
174carnitine transmembrane transport (GO:1902603)2.42406690
175hormone catabolic process (GO:0042447)2.42234489
176fatty acid oxidation (GO:0019395)2.40344641
177positive regulation of lipid catabolic process (GO:0050996)2.38423829
178bile acid biosynthetic process (GO:0006699)2.38146040
179regulation of ARF protein signal transduction (GO:0032012)2.38067911
180regulation of interferon-beta biosynthetic process (GO:0045357)2.37787488
181sequestering of metal ion (GO:0051238)2.37002662
182protein localization to endosome (GO:0036010)2.35886817
183lipid oxidation (GO:0034440)2.34711101
184intracellular lipid transport (GO:0032365)2.34339866
185regulation of membrane protein ectodomain proteolysis (GO:0051043)2.33928609
186L-alpha-amino acid transmembrane transport (GO:1902475)2.33138365
187regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.30665141
188regulation of cholesterol storage (GO:0010885)2.30438642
189* response to unfolded protein (GO:0006986)2.30011163
190short-chain fatty acid metabolic process (GO:0046459)2.29531013
191glutamate metabolic process (GO:0006536)2.28451511
192fatty acid homeostasis (GO:0055089)2.27971774
193triglyceride homeostasis (GO:0070328)2.27817114
194branching involved in labyrinthine layer morphogenesis (GO:0060670)11.9840923

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human5.52825100
2* ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.96215844
3SMAD_19615063_ChIP-ChIP_OVARY_Human4.62770738
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.84760279
5* LXR_22158963_ChIP-Seq_LIVER_Mouse3.48323561
6* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.40803732
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.23233610
8GATA1_22025678_ChIP-Seq_K562_Human3.15197096
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.79998934
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.76201104
11* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.69008158
12E2F7_22180533_ChIP-Seq_HELA_Human2.47362207
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.46136751
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.33972084
15CLOCK_20551151_ChIP-Seq_293T_Human2.32117570
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.28712227
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.24759478
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.20176084
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.07250360
20EGR1_23403033_ChIP-Seq_LIVER_Mouse2.02524635
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.97532314
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.95722260
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.87912512
24* FOXA2_19822575_ChIP-Seq_HepG2_Human1.86475531
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76846121
26CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.75076280
27SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.75029120
28SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.75029120
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74908192
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.70742345
31BRD4_25478319_ChIP-Seq_HGPS_Human1.69556238
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.69354763
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68374943
34ESR1_20079471_ChIP-ChIP_T-47D_Human1.67398332
35GBX2_23144817_ChIP-Seq_PC3_Human1.65478575
36PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64311433
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.63791369
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63262586
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.61352282
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.57782477
41* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57593970
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56175557
43FOXM1_26456572_ChIP-Seq_MCF-7_Human1.55806989
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.54853666
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51156287
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.48180499
47* TBX20_22328084_ChIP-Seq_HEART_Mouse1.46988182
48* TBX20_22080862_ChIP-Seq_HEART_Mouse1.46988182
49* GATA2_21666600_ChIP-Seq_HMVEC_Human1.44368696
50BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.42642660
51* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.41755882
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41466139
53* NANOG_18555785_Chip-Seq_ESCs_Mouse1.40027663
54* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.39118243
55* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38253517
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.35213780
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34894683
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34894683
59GATA1_19941826_ChIP-Seq_K562_Human1.34380960
60TP53_18474530_ChIP-ChIP_U2OS_Human1.33409195
61EP300_21415370_ChIP-Seq_HL-1_Mouse1.32626002
62TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.28137273
63* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26699380
64PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26413604
65* CMYC_18555785_Chip-Seq_ESCs_Mouse1.25868809
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25747841
67RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24976356
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.24796577
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23409777
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23342783
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23241163
72TFEB_21752829_ChIP-Seq_HELA_Human1.21697418
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20658385
74CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20580553
75* E2F1_18555785_Chip-Seq_ESCs_Mouse1.20068471
76* SMAD4_21799915_ChIP-Seq_A2780_Human1.19056764
77FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16190351
78* GATA2_19941826_ChIP-Seq_K562_Human1.15354930
79ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15012192
80ELK1_19687146_ChIP-ChIP_HELA_Human1.14371221
81SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13970494
82* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13920566
83* P300_18555785_Chip-Seq_ESCs_Mouse1.13608118
84RUNX_20019798_ChIP-Seq_JUKART_Human1.12831293
85TP53_16413492_ChIP-PET_HCT116_Human1.12815892
86ER_23166858_ChIP-Seq_MCF-7_Human1.12246600
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11767899
88* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11613321
89CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11176632
90* FUS_26573619_Chip-Seq_HEK293_Human1.10760213
91* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10414763
92SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10312269
93AHR_22903824_ChIP-Seq_MCF-7_Human1.10221474
94CDX2_22108803_ChIP-Seq_LS180_Human1.08601907
95* OCT4_18555785_Chip-Seq_ESCs_Mouse1.08276630
96* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08248137
97* P53_22387025_ChIP-Seq_ESCs_Mouse1.08014175
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07473673
99STAT3_23295773_ChIP-Seq_U87_Human1.06562893
100KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06540040
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06352619
102SPI1_23127762_ChIP-Seq_K562_Human1.05554710
103MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05538739
104* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04878168
105FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04099305
106* SOX2_18555785_Chip-Seq_ESCs_Mouse1.04061736
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03997431
108SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03760937
109VDR_24787735_ChIP-Seq_THP-1_Human1.02943627
110TCF7_22412390_ChIP-Seq_EML_Mouse1.02870896
111STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.02625760
112* NMYC_18555785_Chip-Seq_ESCs_Mouse1.02533086
113* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01379472
114FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.01075863
115NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99798733
116NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99776111
117* HNF4A_19822575_ChIP-Seq_HepG2_Human0.99655308
118LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99168667
119PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99043531
120* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98750694
121* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98559297
122TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98422367
123ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98368586
124CJUN_26792858_Chip-Seq_BT549_Human0.97890193
125* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97689407
126ARNT_22903824_ChIP-Seq_MCF-7_Human0.97331655
127DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97121514
128* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.97000888
129* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96663324
130* PU1_27457419_Chip-Seq_LIVER_Mouse0.96544016
131PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96512824
132RXR_22108803_ChIP-Seq_LS180_Human0.96230847
133RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95773083
134SOX2_20726797_ChIP-Seq_SW620_Human0.95214454
135* GATA6_25053715_ChIP-Seq_YYC3_Human0.93938646
136* STAT3_18555785_Chip-Seq_ESCs_Mouse0.93595531
137KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93499914
138FOXA1_25552417_ChIP-Seq_VCAP_Human0.93146171
139* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92990456
140GATA1_19941827_ChIP-Seq_MEL_Mouse0.92560641
141GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91835291
142PRDM14_20953172_ChIP-Seq_ESCs_Human0.91772178
143ZNF263_19887448_ChIP-Seq_K562_Human0.91749436
144GATA4_25053715_ChIP-Seq_YYC3_Human0.91607819
145HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91272375
146SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90872581
147NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90296715
148BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90105551
149E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89280946
150* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88933870
151PIAS1_25552417_ChIP-Seq_VCAP_Human0.88840171
152BCAT_22108803_ChIP-Seq_LS180_Human0.87623421
153TP63_23658742_ChIP-Seq_EP156T_Human0.87234014
154KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87176921

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.05845700
2MP0002139_abnormal_hepatobiliary_system4.70737903
3MP0000516_abnormal_urinary_system3.96782340
4MP0005367_renal/urinary_system_phenotyp3.96782340
5MP0005365_abnormal_bile_salt3.49611123
6MP0005085_abnormal_gallbladder_physiolo3.38568598
7MP0001661_extended_life_span3.18327471
8MP0003300_gastrointestinal_ulcer3.16018992
9MP0003252_abnormal_bile_duct3.10173349
10MP0005360_urolithiasis2.97405407
11MP0002877_abnormal_melanocyte_morpholog2.85601921
12MP0001849_ear_inflammation2.67209704
13MP0003195_calcinosis2.52960157
14MP0003315_abnormal_perineum_morphology2.42722235
15MP0002837_dystrophic_cardiac_calcinosis2.40850394
16MP0009780_abnormal_chondrocyte_physiolo2.29432907
17MP0008875_abnormal_xenobiotic_pharmacok2.25306730
18MP0009840_abnormal_foam_cell2.20286716
19MP0005058_abnormal_lysosome_morphology2.15617000
20MP0001666_abnormal_nutrient_absorption2.15035607
21MP0002138_abnormal_hepatobiliary_system2.14656973
22MP0009053_abnormal_anal_canal2.13004170
23MP0010329_abnormal_lipoprotein_level2.11679266
24MP0003705_abnormal_hypodermis_morpholog2.08313753
25MP0003868_abnormal_feces_composition2.01388019
26MP0003191_abnormal_cellular_cholesterol1.96138465
27MP0005083_abnormal_biliary_tract1.90261726
28MP0010678_abnormal_skin_adnexa1.89977014
29MP0001485_abnormal_pinna_reflex1.85149605
30MP0003693_abnormal_embryo_hatching1.84097293
31MP0002909_abnormal_adrenal_gland1.81250458
32MP0000015_abnormal_ear_pigmentation1.80598780
33MP0004130_abnormal_muscle_cell1.79801913
34MP0010234_abnormal_vibrissa_follicle1.72181127
35MP0000383_abnormal_hair_follicle1.63495816
36MP0003045_fibrosis1.62165093
37MP0008438_abnormal_cutaneous_collagen1.60174569
38MP0004510_myositis1.56995790
39MP0003183_abnormal_peptide_metabolism1.55816848
40* MP0000609_abnormal_liver_physiology1.53804951
41MP0004043_abnormal_pH_regulation1.51051902
42MP0002118_abnormal_lipid_homeostasis1.50615271
43MP0004264_abnormal_extraembryonic_tissu1.49190414
44MP0003172_abnormal_lysosome_physiology1.48751212
45MP0002693_abnormal_pancreas_physiology1.46475966
46MP0003566_abnormal_cell_adhesion1.43619447
47MP0004084_abnormal_cardiac_muscle1.43113739
48MP0005164_abnormal_response_to1.42163396
49MP0003303_peritoneal_inflammation1.40050862
50MP0002876_abnormal_thyroid_physiology1.38837956
51MP0005220_abnormal_exocrine_pancreas1.38293902
52MP0005646_abnormal_pituitary_gland1.37145083
53MP0005332_abnormal_amino_acid1.37132143
54MP0002078_abnormal_glucose_homeostasis1.36294867
55MP0001944_abnormal_pancreas_morphology1.33887034
56MP0008057_abnormal_DNA_replication1.33037420
57MP0000569_abnormal_digit_pigmentation1.31645004
58MP0004036_abnormal_muscle_relaxation1.31270730
59MP0002282_abnormal_trachea_morphology1.29765606
60MP0005319_abnormal_enzyme/_coenzyme1.28074526
61MP0000003_abnormal_adipose_tissue1.27891101
62MP0009643_abnormal_urine_homeostasis1.27447365
63MP0008961_abnormal_basal_metabolism1.26099091
64MP0002928_abnormal_bile_duct1.21316159
65MP0003656_abnormal_erythrocyte_physiolo1.20923019
66MP0000013_abnormal_adipose_tissue1.20789516
67MP0001835_abnormal_antigen_presentation1.20064861
68MP0002166_altered_tumor_susceptibility1.17103840
69MP0001915_intracranial_hemorrhage1.16984347
70MP0005330_cardiomyopathy1.15572968
71MP0002653_abnormal_ependyma_morphology1.15351274
72MP0004087_abnormal_muscle_fiber1.15133636
73MP0004185_abnormal_adipocyte_glucose1.12663353
74MP0002132_abnormal_respiratory_system1.09719458
75MP0002060_abnormal_skin_morphology1.08779798
76MP0005310_abnormal_salivary_gland1.08210255
77MP0005375_adipose_tissue_phenotype1.08151389
78MP0000604_amyloidosis1.06466639
79MP0003950_abnormal_plasma_membrane1.05327683
80MP0005174_abnormal_tail_pigmentation1.04640562
81MP0000749_muscle_degeneration1.04425988
82MP0002269_muscular_atrophy1.04321691
83MP0005666_abnormal_adipose_tissue1.03223470
84MP0005076_abnormal_cell_differentiation1.02824363
85MP0005409_darkened_coat_color1.01011462
86MP0000747_muscle_weakness1.00775261
87MP0001697_abnormal_embryo_size1.00536915
88MP0005670_abnormal_white_adipose0.99602084
89MP0010630_abnormal_cardiac_muscle0.98395200
90MP0002896_abnormal_bone_mineralization0.95897378
91MP0003075_altered_response_to0.95281240
92MP0001756_abnormal_urination0.95166483
93* MP0009765_abnormal_xenobiotic_induced0.94958955
94MP0001765_abnormal_ion_homeostasis0.93950356
95MP0009115_abnormal_fat_cell0.93431862
96MP0010368_abnormal_lymphatic_system0.93175990
97MP0002972_abnormal_cardiac_muscle0.92987167
98MP0000537_abnormal_urethra_morphology0.92365670
99MP0003690_abnormal_glial_cell0.91807727
100MP0000751_myopathy0.91797003
101MP0003436_decreased_susceptibility_to0.90997350
102MP0002168_other_aberrant_phenotype0.90447799
103MP0000613_abnormal_salivary_gland0.89192279
104MP0003936_abnormal_reproductive_system0.89060955
105MP0004215_abnormal_myocardial_fiber0.88133904
106MP0005584_abnormal_enzyme/coenzyme_acti0.87276384
107MP0002086_abnormal_extraembryonic_tissu0.86542611
108MP0005334_abnormal_fat_pad0.86143976
109MP0010352_gastrointestinal_tract_polyps0.85753873
110MP0000627_abnormal_mammary_gland0.85328659
111MP0002160_abnormal_reproductive_system0.83396695
112MP0002090_abnormal_vision0.83160463
113MP0000598_abnormal_liver_morphology0.82565876
114MP0006054_spinal_hemorrhage0.81777979
115MP0002419_abnormal_innate_immunity0.79136153
116MP0005275_abnormal_skin_tensile0.79115707
117MP0003937_abnormal_limbs/digits/tail_de0.78495148
118MP0003091_abnormal_cell_migration0.76493292
119MP0004808_abnormal_hematopoietic_stem0.76432303
120MP0002234_abnormal_pharynx_morphology0.74068518
121MP0004381_abnormal_hair_follicle0.73977080
122MP0001533_abnormal_skeleton_physiology0.73385151
123MP0004947_skin_inflammation0.73315085
124MP0003119_abnormal_digestive_system0.73164887
125MP0002295_abnormal_pulmonary_circulatio0.72937124
126MP0008469_abnormal_protein_level0.71739665
127MP0002971_abnormal_brown_adipose0.71315808
128MP0005620_abnormal_muscle_contractility0.70802472
129MP0002006_tumorigenesis0.70746445
130MP0003806_abnormal_nucleotide_metabolis0.69895163
131MP0005023_abnormal_wound_healing0.69865772
132MP0010386_abnormal_urinary_bladder0.69618020
133MP0000371_diluted_coat_color0.69165046
134MP0008775_abnormal_heart_ventricle0.69001361
135MP0003279_aneurysm0.67681296
136MP0002135_abnormal_kidney_morphology0.67396538
137MP0000767_abnormal_smooth_muscle0.67288495
138MP0000230_abnormal_systemic_arterial0.67045240
139MP0005535_abnormal_body_temperature0.66910020
140MP0005397_hematopoietic_system_phenotyp0.66773503
141MP0001545_abnormal_hematopoietic_system0.66773503
142MP0005464_abnormal_platelet_physiology0.66644316
143MP0009642_abnormal_blood_homeostasis0.65306941
144MP0002396_abnormal_hematopoietic_system0.65093012
145MP0000049_abnormal_middle_ear0.64206143
146MP0001216_abnormal_epidermal_layer0.63070767
147MP0005408_hypopigmentation0.62258147
148MP0004782_abnormal_surfactant_physiolog0.60875963
149MP0001879_abnormal_lymphatic_vessel0.59371687
150MP0000377_abnormal_hair_follicle0.59099245
151MP0002998_abnormal_bone_remodeling0.57466171
152MP0004272_abnormal_basement_membrane0.56014668
153MP0000685_abnormal_immune_system0.53577489
154MP0002148_abnormal_hypersensitivity_rea0.52952957
155MP0003890_abnormal_embryonic-extraembry0.52554178
156MP0005000_abnormal_immune_tolerance0.52304231
157MP0000467_abnormal_esophagus_morphology0.50385874
158MP0005451_abnormal_body_composition0.47446868
159MP0002177_abnormal_outer_ear0.47370652
160MP0003283_abnormal_digestive_organ0.47186927
161MP0005389_reproductive_system_phenotype0.47077878
162MP0004134_abnormal_chest_morphology0.45968619

Predicted human phenotypes

RankGene SetZ-score
1Short 1st metacarpal (HP:0010034)7.96787226
2Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)7.96787226
3Abnormality of the 1st metacarpal (HP:0010009)6.92308609
4Stenosis of the external auditory canal (HP:0000402)6.66532478
5Carpal bone hypoplasia (HP:0001498)5.53489569
6Ectopic kidney (HP:0000086)5.38581084
7Fused cervical vertebrae (HP:0002949)4.94949968
8Short phalanx of the thumb (HP:0009660)4.89702139
9Rectovaginal fistula (HP:0000143)4.59151141
10Rectal fistula (HP:0100590)4.59151141
11Hypoglycemic coma (HP:0001325)4.15965531
12Intestinal fistula (HP:0100819)4.08723579
13Vaginal fistula (HP:0004320)4.02809873
14Reduced subcutaneous adipose tissue (HP:0003758)3.98264532
15Intrahepatic cholestasis (HP:0001406)3.89646890
16Chromosomal breakage induced by crosslinking agents (HP:0003221)3.77420661
17Toxemia of pregnancy (HP:0100603)3.73577750
18Short hallux (HP:0010109)3.71388686
19Ketoacidosis (HP:0001993)3.71061288
20Hyperinsulinemic hypoglycemia (HP:0000825)3.55184499
21Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.53471079
22Deep venous thrombosis (HP:0002625)3.52071015
23Duplicated collecting system (HP:0000081)3.46827558
24Abnormality of the renal collecting system (HP:0004742)3.43470062
25Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.40866535
26Osteomalacia (HP:0002749)3.40553278
27Chromsome breakage (HP:0040012)3.40212928
28Aplasia/Hypoplasia of the hallux (HP:0008362)3.38179102
29Absent thumb (HP:0009777)3.37799909
30Short humerus (HP:0005792)3.35591238
31Complement deficiency (HP:0004431)3.34288688
32Hypoglycemic seizures (HP:0002173)3.33304118
33Hyperglycemia (HP:0003074)3.28723218
34Xanthomatosis (HP:0000991)3.27300647
35Abnormality of the common coagulation pathway (HP:0010990)3.25984591
36Abnormality of monocarboxylic acid metabolism (HP:0010996)3.25469542
37Abnormality of the intrinsic pathway (HP:0010989)3.23961205
38Oligomenorrhea (HP:0000876)3.22584018
39Abnormality of DNA repair (HP:0003254)3.21195356
40Decreased subcutaneous fat (HP:0001002)3.20554656
41Ketosis (HP:0001946)3.18943887
42Asymmetric septal hypertrophy (HP:0001670)3.18710344
43Aplasia/Hypoplasia involving the musculature (HP:0001460)3.15398287
44Myocardial infarction (HP:0001658)3.13339481
45Abnormality of the nasal septum (HP:0000419)3.11511069
46Anal stenosis (HP:0002025)3.06142055
47Mucopolysacchariduria (HP:0008155)2.99385460
48Urinary glycosaminoglycan excretion (HP:0003541)2.99385460
49Aplasia/hypoplasia of the humerus (HP:0006507)2.96256945
50Abnormality of the parathyroid morphology (HP:0011766)2.92708435
51Abnormality of pyrimidine metabolism (HP:0004353)2.86638171
52Abnormality of the proximal phalanges of the hand (HP:0009834)2.82178558
53Abnormality of glycosaminoglycan metabolism (HP:0004371)2.81820828
54Abnormality of mucopolysaccharide metabolism (HP:0011020)2.81820828
55Abnormality of polysaccharide metabolism (HP:0011012)2.81820828
56Acanthocytosis (HP:0001927)2.80541163
57Dysostosis multiplex (HP:0000943)2.76119938
58Hypoalphalipoproteinemia (HP:0003233)2.74189895
59Right ventricular cardiomyopathy (HP:0011663)2.73456328
60Abnormality of aromatic amino acid family metabolism (HP:0004338)2.72437496
61Skin nodule (HP:0200036)2.69400478
62Abnormality of complement system (HP:0005339)2.64293446
63Synostosis of carpal bones (HP:0005048)2.63378503
64Bundle branch block (HP:0011710)2.62564127
65Horseshoe kidney (HP:0000085)2.61285255
66Abnormality of subcutaneous fat tissue (HP:0001001)2.55524724
67Absent radius (HP:0003974)2.55128447
68Hyporeflexia of lower limbs (HP:0002600)2.54010958
69Insulin-resistant diabetes mellitus (HP:0000831)2.50199093
70Symptomatic seizures (HP:0011145)2.46591354
71Mitral stenosis (HP:0001718)2.46010313
72Disproportionate short-trunk short stature (HP:0003521)2.43935907
73Systemic lupus erythematosus (HP:0002725)2.43291516
74Abnormality of the distal phalanges of the toes (HP:0010182)2.42862013
75Abnormality of endocrine pancreas physiology (HP:0012093)2.41311436
76Abnormality of the pancreatic islet cells (HP:0006476)2.41311436
77Congenital sensorineural hearing impairment (HP:0008527)2.40151933
78Epidermoid cyst (HP:0200040)2.38919054
79Pancreatic islet-cell hyperplasia (HP:0004510)2.38558918
80Hyperlipoproteinemia (HP:0010980)2.36183675
81Increased purine levels (HP:0004368)2.34296717
82Hyperuricemia (HP:0002149)2.34296717
83Aplasia involving forearm bones (HP:0009822)2.31435772
84Absent forearm bone (HP:0003953)2.31435772
85Prolonged partial thromboplastin time (HP:0003645)2.29905437
86Aneurysm (HP:0002617)2.27904176
87Joint hemorrhage (HP:0005261)2.23325357
88Abnormality of the carotid arteries (HP:0005344)2.22610420
89Atrioventricular block (HP:0001678)2.21767039
90Increased cerebral lipofuscin (HP:0011813)2.21632792
91Hyperammonemia (HP:0001987)2.19962506
92Polygenic inheritance (HP:0010982)2.18912658
93Albinism (HP:0001022)2.18704991
94Sudden death (HP:0001699)2.18208730
95Late onset (HP:0003584)2.18081718
96Abnormality of sulfur amino acid metabolism (HP:0004339)2.16449332
97Hypolipoproteinemia (HP:0010981)2.15098109
98Cerebral aneurysm (HP:0004944)2.14016475
99Neoplasm of the oral cavity (HP:0100649)2.13767869
100Wide intermamillary distance (HP:0006610)2.13641265
101Hypoplasia of the odontoid process (HP:0003311)2.13494388
102Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.13450958
103Conjugated hyperbilirubinemia (HP:0002908)2.13139803
104Abnormality of the odontoid process (HP:0003310)2.08055501
105Glomerulonephritis (HP:0000099)2.07392340
106Retinal atrophy (HP:0001105)2.07066414
107Protuberant abdomen (HP:0001538)2.05794997
108Myoglobinuria (HP:0002913)2.05283453
109Abnormality of glycolipid metabolism (HP:0010969)2.02958501
110Abnormality of liposaccharide metabolism (HP:0010968)2.02958501
111Abnormality of glycosphingolipid metabolism (HP:0004343)2.02958501
112Fat malabsorption (HP:0002630)2.01696988
113Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.99685102
114Abnormality of glutamine family amino acid metabolism (HP:0010902)1.99298658
115Short thumb (HP:0009778)1.99296778
116Macroorchidism (HP:0000053)1.96265462
117Global brain atrophy (HP:0002283)1.96117802
118Exercise-induced myalgia (HP:0003738)1.96082706
119Abnormal gallbladder morphology (HP:0012437)1.93764426
120Abnormality of fatty-acid metabolism (HP:0004359)1.93759959
121Hematochezia (HP:0002573)1.93412606
122Hepatocellular carcinoma (HP:0001402)1.93280279
123Chorioretinal atrophy (HP:0000533)1.91984466
124Pathologic fracture (HP:0002756)1.91236589
125Abnormality of chromosome stability (HP:0003220)1.91185019
126Abnormal atrioventricular conduction (HP:0005150)1.91063444
127Curly hair (HP:0002212)1.90727673
128Abnormality of nucleobase metabolism (HP:0010932)1.90078129
129Leukocytosis (HP:0001974)1.89070925
130Menstrual irregularities (HP:0000858)1.89070544
131Heart block (HP:0012722)1.87468595
132Recurrent gram-negative bacterial infections (HP:0005420)1.86490588
133Increased CSF protein (HP:0002922)1.85497550
134Abnormality of purine metabolism (HP:0004352)1.85170740
135Papilledema (HP:0001085)1.84690260
136Generalized aminoaciduria (HP:0002909)1.84294533
137Aortic aneurysm (HP:0004942)1.82779646
138Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.82109668
139Exercise-induced muscle cramps (HP:0003710)1.81661533
140Abnormality of the middle phalanges of the toes (HP:0010183)1.80368980
141Flared iliac wings (HP:0002869)1.80314852
142Sensorimotor neuropathy (HP:0007141)1.80287601
143Increased neuronal autofluorescent lipopigment (HP:0002074)1.80006405
144Cholelithiasis (HP:0001081)1.79582135
145Transitional cell carcinoma of the bladder (HP:0006740)1.77795694
146Esophageal varix (HP:0002040)1.76321495
147Subacute progressive viral hepatitis (HP:0006572)1.75655871
148Long toe (HP:0010511)1.75459638
149Syncope (HP:0001279)1.74539844
150Insulin resistance (HP:0000855)1.74353282
151Hamartoma of the eye (HP:0010568)1.74126694
152Abnormality of proline metabolism (HP:0010907)1.73712964
153Hydroxyprolinuria (HP:0003080)1.73712964
154Tented upper lip vermilion (HP:0010804)1.73590220
155Nephritis (HP:0000123)1.72858983
156Increased connective tissue (HP:0009025)1.72374280
157Vitreoretinal degeneration (HP:0000655)1.72253819
158Axonal loss (HP:0003447)1.72070565
159Vertebral fusion (HP:0002948)1.71743456
160Abnormality of the musculature of the hand (HP:0001421)1.71639812
161Abnormality of the Achilles tendon (HP:0005109)1.70811599
162Onion bulb formation (HP:0003383)1.70198764
163Large for gestational age (HP:0001520)1.70149549
164Ureteral duplication (HP:0000073)1.69783223
165Vascular calcification (HP:0004934)1.69372949
166Neoplasm of the thyroid gland (HP:0100031)1.69257115
167Cardiovascular calcification (HP:0011915)1.68584829
168Hypobetalipoproteinemia (HP:0003563)1.68351260
169Dysmetric saccades (HP:0000641)1.67691410
170Bladder carcinoma (HP:0002862)1.67611285
171Bladder neoplasm (HP:0009725)1.67611285
172Hyperglycinuria (HP:0003108)1.66799580
173Difficulty climbing stairs (HP:0003551)1.66277375
174Abnormality of the preputium (HP:0100587)1.65061711
175Osteolytic defects of the phalanges of the hand (HP:0009771)1.63970420
176Osteolytic defects of the hand bones (HP:0009699)1.63970420
177Upper limb amyotrophy (HP:0009129)1.63590762
178Distal upper limb amyotrophy (HP:0007149)1.63590762
179Stroke (HP:0001297)1.63006155
180Carpal synostosis (HP:0009702)1.62783108
181Hypoplastic ischia (HP:0003175)1.62193467
182Atrial fibrillation (HP:0005110)1.61823226
183Papillary thyroid carcinoma (HP:0002895)1.61406394
184Optic nerve coloboma (HP:0000588)1.59447588
185Submucous cleft hard palate (HP:0000176)1.59001898
186Renal agenesis (HP:0000104)1.57602751
187Paralysis (HP:0003470)1.56635521

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.14514590
2CDK94.02864160
3ERN13.79830479
4INSRR3.41102178
5TRIB33.39940458
6PKN22.93951878
7EIF2AK32.92372657
8GRK12.66611087
9FRK2.65873696
10TRIM282.59278063
11TTN2.24939573
12SIK32.22268409
13SIK12.14333722
14RIPK12.10308044
15LATS12.05803041
16CLK12.05175193
17PLK21.84077892
18PTK61.82750307
19JAK11.82148740
20BCKDK1.80122558
21MAP3K21.74183819
22TAF11.71801122
23BLK1.70375361
24CAMK1D1.65813322
25EIF2AK11.60867368
26SCYL21.57971876
27FLT31.56334186
28ACVR1B1.53977773
29NLK1.47277354
30FGFR41.47209347
31DMPK1.46610532
32CAMK1G1.46544588
33EPHB11.40953586
34PDGFRA1.36995601
35STK31.36192740
36IRAK11.29471489
37TYK21.26433314
38STK391.23458029
39NEK91.22144180
40CDC71.17706412
41AKT31.17265776
42JAK21.16633394
43BMPR21.15486036
44SGK31.14279027
45BRSK21.09156680
46IRAK31.07900027
47RET1.07039897
48HIPK21.05360150
49FGFR31.01947537
50YES11.01854726
51PRKCH1.01748475
52MELK1.01292717
53TBK11.01048869
54EPHA31.00584331
55PBK0.99246527
56TGFBR20.96671789
57CAMKK10.96643093
58MST1R0.95195671
59BRD40.94681201
60MAP3K10.94186586
61LMTK20.92663039
62FER0.92005543
63PIK3CG0.91314207
64PRKD30.90203059
65MAP3K70.90029988
66MAP2K30.87588522
67MAP3K120.87454817
68STK100.86792684
69CSNK1A1L0.85817963
70KSR10.85662744
71MAP3K30.83322874
72BCR0.80800219
73CDK60.79579991
74PIK3CA0.77797023
75ERBB30.77190552
76KSR20.76724399
77MAP3K140.75333477
78PDK10.75112933
79PDPK10.74812677
80PDGFRB0.73427516
81TIE10.73254718
82MTOR0.71846645
83PDK20.71799429
84EEF2K0.71618601
85MAPK150.71524229
86SGK20.70540713
87RIPK40.70425156
88MAP3K100.70155453
89PTK20.69129291
90CDC42BPA0.68725636
91PRKAA10.67441230
92MAP3K50.67052138
93ADRBK20.66875174
94BMX0.66706106
95PRKD10.66531535
96LRRK20.66386082
97MET0.65931809
98CAMKK20.65592976
99TEC0.64851720
100PRKAA20.64756555
101DYRK30.64285397
102PRKD20.63922775
103CSNK1G10.63451360
104TAOK10.61971395
105CSF1R0.58458877
106WNK10.58310446
107MAPKAPK20.57398311
108PAK30.57009601
109GRK70.56971162
110SGK4940.56965855
111SGK2230.56965855
112JAK30.56747786
113LYN0.56366320
114SYK0.56076043
115RPS6KB10.54943617
116MAP2K40.54830816
117STK240.54680759
118BMPR1B0.54482935
119DAPK20.53523814
120ITK0.52801317
121ATR0.52015085
122CHUK0.50283694
123CSNK1G30.49882414
124OBSCN0.49341991
125MAP2K10.49147898
126HCK0.48653540
127PRKCE0.48349572
128CDK120.47078117
129MST40.46780690
130FES0.45974768
131TRPM70.45371569
132CSNK1G20.45305438
133CSK0.44901806
134ALK0.44672759
135SGK10.44568400
136STK380.44036029
137GSK3A0.43659985
138PTK2B0.43221319
139EGFR0.42998667
140ABL10.42574011
141NTRK10.42275746
142ATM0.42018970
143FGFR20.41260466
144NUAK10.41149195
145STK40.40446655
146MAP4K10.40119683
147DYRK1B0.39818345
148MAPK110.39256593
149KIT0.38465832
150MAP3K130.37684305
151ZAP700.35872725
152PRKACG0.34695521

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.24027045
2Thyroid cancer_Homo sapiens_hsa052162.86384624
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.78123787
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.68926961
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.27588587
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20213431
7Fatty acid degradation_Homo sapiens_hsa000712.08787571
8Arginine biosynthesis_Homo sapiens_hsa002202.04573473
9Complement and coagulation cascades_Homo sapiens_hsa046101.80657005
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.79378042
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.76356801
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75660232
13Protein export_Homo sapiens_hsa030601.74506150
14Tryptophan metabolism_Homo sapiens_hsa003801.66161139
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.63947594
16Collecting duct acid secretion_Homo sapiens_hsa049661.58443670
17* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.53817166
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.52736954
19Staphylococcus aureus infection_Homo sapiens_hsa051501.48715797
20Galactose metabolism_Homo sapiens_hsa000521.47613817
21Sulfur metabolism_Homo sapiens_hsa009201.42516254
22Starch and sucrose metabolism_Homo sapiens_hsa005001.40473246
23Insulin resistance_Homo sapiens_hsa049311.40151658
24Type II diabetes mellitus_Homo sapiens_hsa049301.39167053
25Propanoate metabolism_Homo sapiens_hsa006401.38324059
26PPAR signaling pathway_Homo sapiens_hsa033201.36222191
27Sphingolipid metabolism_Homo sapiens_hsa006001.35054107
28Renal cell carcinoma_Homo sapiens_hsa052111.33497639
29Fatty acid metabolism_Homo sapiens_hsa012121.32894123
30ABC transporters_Homo sapiens_hsa020101.32003888
31Selenocompound metabolism_Homo sapiens_hsa004501.31819765
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.28041290
33Bile secretion_Homo sapiens_hsa049761.28017662
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26221703
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.22928199
36Caffeine metabolism_Homo sapiens_hsa002321.16810698
37Lysine degradation_Homo sapiens_hsa003101.16765760
38Lysosome_Homo sapiens_hsa041421.16327169
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15470258
40Hematopoietic cell lineage_Homo sapiens_hsa046401.13528518
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13073556
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12128616
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03103956
44Insulin secretion_Homo sapiens_hsa049111.02844293
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02731674
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98007440
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97874551
48Adipocytokine signaling pathway_Homo sapiens_hsa049200.97728676
49Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96971500
50Fanconi anemia pathway_Homo sapiens_hsa034600.95827047
51Hepatitis B_Homo sapiens_hsa051610.95498679
52Fat digestion and absorption_Homo sapiens_hsa049750.94723677
53Butanoate metabolism_Homo sapiens_hsa006500.93101368
54Melanoma_Homo sapiens_hsa052180.92646806
55TGF-beta signaling pathway_Homo sapiens_hsa043500.91972544
56Dilated cardiomyopathy_Homo sapiens_hsa054140.88513655
57Measles_Homo sapiens_hsa051620.85612754
58Pancreatic cancer_Homo sapiens_hsa052120.85050863
59Systemic lupus erythematosus_Homo sapiens_hsa053220.84879823
60Glucagon signaling pathway_Homo sapiens_hsa049220.83896970
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.83856293
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83590959
63beta-Alanine metabolism_Homo sapiens_hsa004100.83164905
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82915642
65TNF signaling pathway_Homo sapiens_hsa046680.82066567
66p53 signaling pathway_Homo sapiens_hsa041150.81897980
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.81051548
68Peroxisome_Homo sapiens_hsa041460.80356391
69Malaria_Homo sapiens_hsa051440.79899763
70Pancreatic secretion_Homo sapiens_hsa049720.77801764
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76612348
72Phenylalanine metabolism_Homo sapiens_hsa003600.76310849
73Legionellosis_Homo sapiens_hsa051340.76238118
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74740539
75Small cell lung cancer_Homo sapiens_hsa052220.72989058
76Type I diabetes mellitus_Homo sapiens_hsa049400.71109241
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70822091
78Osteoclast differentiation_Homo sapiens_hsa043800.70702161
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69486482
80B cell receptor signaling pathway_Homo sapiens_hsa046620.69145145
81Glycerolipid metabolism_Homo sapiens_hsa005610.68650274
82Prion diseases_Homo sapiens_hsa050200.67923081
83mTOR signaling pathway_Homo sapiens_hsa041500.67239072
84Pathways in cancer_Homo sapiens_hsa052000.66975359
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66254115
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65546008
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65164142
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64183425
89Insulin signaling pathway_Homo sapiens_hsa049100.63088228
90Influenza A_Homo sapiens_hsa051640.62620039
91Viral carcinogenesis_Homo sapiens_hsa052030.62435524
92Amoebiasis_Homo sapiens_hsa051460.62426741
93Histidine metabolism_Homo sapiens_hsa003400.62371282
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60882176
95Carbon metabolism_Homo sapiens_hsa012000.60862371
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.60782858
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60030471
98RNA degradation_Homo sapiens_hsa030180.60006847
99Tyrosine metabolism_Homo sapiens_hsa003500.59711189
100Thyroid hormone synthesis_Homo sapiens_hsa049180.59657036
101Focal adhesion_Homo sapiens_hsa045100.59152264
102African trypanosomiasis_Homo sapiens_hsa051430.59055070
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58874114
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57864432
105Dorso-ventral axis formation_Homo sapiens_hsa043200.55732286
106Hepatitis C_Homo sapiens_hsa051600.55276414
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53651949
108AMPK signaling pathway_Homo sapiens_hsa041520.53518346
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52672047
110MicroRNAs in cancer_Homo sapiens_hsa052060.52589736
111Other glycan degradation_Homo sapiens_hsa005110.51831177
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51756773
113Pyruvate metabolism_Homo sapiens_hsa006200.51397185
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51319275
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50926544
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50762550
117Pertussis_Homo sapiens_hsa051330.50084424
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49671831
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48700872
120Phagosome_Homo sapiens_hsa041450.44550031
121Chemical carcinogenesis_Homo sapiens_hsa052040.44039722
122Toxoplasmosis_Homo sapiens_hsa051450.43920646
123Adherens junction_Homo sapiens_hsa045200.43803735
124Circadian rhythm_Homo sapiens_hsa047100.43110234
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42913281
126Glioma_Homo sapiens_hsa052140.42750858
127Inositol phosphate metabolism_Homo sapiens_hsa005620.42588482
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42206054
129Ether lipid metabolism_Homo sapiens_hsa005650.41592870
130Protein digestion and absorption_Homo sapiens_hsa049740.40898257
131Proteoglycans in cancer_Homo sapiens_hsa052050.40280350
132Prolactin signaling pathway_Homo sapiens_hsa049170.40095196
133Prostate cancer_Homo sapiens_hsa052150.39577801
134Chronic myeloid leukemia_Homo sapiens_hsa052200.39536902
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39298529
136Estrogen signaling pathway_Homo sapiens_hsa049150.38999985
137Renin secretion_Homo sapiens_hsa049240.38655846
138Bladder cancer_Homo sapiens_hsa052190.38188142
139FoxO signaling pathway_Homo sapiens_hsa040680.37821092
140Leishmaniasis_Homo sapiens_hsa051400.37496977
141Renin-angiotensin system_Homo sapiens_hsa046140.37156033
142Tuberculosis_Homo sapiens_hsa051520.37078571
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36853578
144Herpes simplex infection_Homo sapiens_hsa051680.36814887
145Mineral absorption_Homo sapiens_hsa049780.36478468
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.36302820
147Non-small cell lung cancer_Homo sapiens_hsa052230.35994337
148Platelet activation_Homo sapiens_hsa046110.35503568
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34705766
150Central carbon metabolism in cancer_Homo sapiens_hsa052300.34605958
151Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34309924
152N-Glycan biosynthesis_Homo sapiens_hsa005100.34180916
153Drug metabolism - other enzymes_Homo sapiens_hsa009830.34082199
154HIF-1 signaling pathway_Homo sapiens_hsa040660.33447760
155Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33304259

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