ATF5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.66080541
2L-phenylalanine catabolic process (GO:0006559)6.66080541
3L-phenylalanine metabolic process (GO:0006558)6.49412416
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.49412416
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.93513237
6aromatic amino acid family catabolic process (GO:0009074)5.74471105
7negative regulation of fibrinolysis (GO:0051918)5.66932143
8alpha-linolenic acid metabolic process (GO:0036109)5.32763450
9regulation of fibrinolysis (GO:0051917)5.23475717
10high-density lipoprotein particle remodeling (GO:0034375)5.16401057
11sulfur amino acid catabolic process (GO:0000098)5.13810447
12kynurenine metabolic process (GO:0070189)5.13002933
13glyoxylate metabolic process (GO:0046487)5.09273178
14protein carboxylation (GO:0018214)5.08803631
15peptidyl-glutamic acid carboxylation (GO:0017187)5.08803631
16cysteine metabolic process (GO:0006534)4.99451476
17bile acid biosynthetic process (GO:0006699)4.97230483
18indolalkylamine catabolic process (GO:0046218)4.96759016
19tryptophan catabolic process (GO:0006569)4.96759016
20indole-containing compound catabolic process (GO:0042436)4.96759016
21urea cycle (GO:0000050)4.82509926
22urea metabolic process (GO:0019627)4.82509926
23regulation of protein activation cascade (GO:2000257)4.67951886
24tryptophan metabolic process (GO:0006568)4.66972450
25complement activation, alternative pathway (GO:0006957)4.58885209
26regulation of triglyceride catabolic process (GO:0010896)4.58097224
27reverse cholesterol transport (GO:0043691)4.53549307
28serine family amino acid catabolic process (GO:0009071)4.42292281
29nitrogen cycle metabolic process (GO:0071941)4.41866543
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.37072676
31regulation of complement activation (GO:0030449)4.36794660
32regulation of cholesterol esterification (GO:0010872)4.36670364
33plasma lipoprotein particle clearance (GO:0034381)4.35454330
34triglyceride homeostasis (GO:0070328)4.34719730
35acylglycerol homeostasis (GO:0055090)4.34719730
36protein-lipid complex remodeling (GO:0034368)4.33123607
37macromolecular complex remodeling (GO:0034367)4.33123607
38plasma lipoprotein particle remodeling (GO:0034369)4.33123607
39lysine catabolic process (GO:0006554)4.31027712
40lysine metabolic process (GO:0006553)4.31027712
41positive regulation of fatty acid beta-oxidation (GO:0032000)4.29229260
42bile acid metabolic process (GO:0008206)4.26086083
43homocysteine metabolic process (GO:0050667)4.25220809
44negative regulation of cholesterol transport (GO:0032375)4.23536919
45negative regulation of sterol transport (GO:0032372)4.23536919
46phospholipid efflux (GO:0033700)4.23298970
47coenzyme catabolic process (GO:0009109)4.18091525
48NIK/NF-kappaB signaling (GO:0038061)4.16176011
49aromatic amino acid family metabolic process (GO:0009072)4.14624722
50amino-acid betaine metabolic process (GO:0006577)4.12153454
51tyrosine metabolic process (GO:0006570)4.11879301
52type I interferon signaling pathway (GO:0060337)4.04322355
53cellular response to type I interferon (GO:0071357)4.04322355
54CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.02994924
55response to type I interferon (GO:0034340)4.02849372
56alpha-amino acid catabolic process (GO:1901606)4.00247867
57regulation of cholesterol homeostasis (GO:2000188)3.96523907
58cellular modified amino acid catabolic process (GO:0042219)3.94902827
59positive regulation of lipid catabolic process (GO:0050996)3.89848867
60regulation of vitamin D biosynthetic process (GO:0060556)3.88154458
61cellular ketone body metabolic process (GO:0046950)3.84846653
62fibrinolysis (GO:0042730)3.84432274
63positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.83434697
64glycine metabolic process (GO:0006544)3.81201101
65cholesterol efflux (GO:0033344)3.80186188
66regulation of fatty acid beta-oxidation (GO:0031998)3.79536124
67glutamate metabolic process (GO:0006536)3.79451909
68myeloid dendritic cell differentiation (GO:0043011)3.76421537
69cellular amino acid catabolic process (GO:0009063)3.74049263
70ethanol oxidation (GO:0006069)3.73848791
71T-helper 1 type immune response (GO:0042088)3.73441630
72regulation of cytokine secretion involved in immune response (GO:0002739)3.72310493
73response to peptidoglycan (GO:0032494)3.71604937
74negative regulation of lipase activity (GO:0060192)3.67514664
75regulation of plasminogen activation (GO:0010755)3.66707609
76positive regulation of lipoprotein lipase activity (GO:0051006)3.65099965
77positive regulation of triglyceride lipase activity (GO:0061365)3.65099965
78serine family amino acid metabolic process (GO:0009069)3.64932240
79plasma lipoprotein particle assembly (GO:0034377)3.64558819
80bile acid and bile salt transport (GO:0015721)3.62675791
81negative regulation of fatty acid biosynthetic process (GO:0045717)3.62510887
82lipopolysaccharide-mediated signaling pathway (GO:0031663)3.61471129
83positive regulation of fatty acid oxidation (GO:0046321)3.60270206
84imidazole-containing compound metabolic process (GO:0052803)3.59962930
85cellular glucuronidation (GO:0052695)3.59933198
86regulation of T-helper 1 cell differentiation (GO:0045625)3.59651478
87regulation of interferon-alpha production (GO:0032647)3.56144738
88serine family amino acid biosynthetic process (GO:0009070)3.51720469
89positive regulation of triglyceride metabolic process (GO:0090208)3.49630044
90dicarboxylic acid biosynthetic process (GO:0043650)3.49467157
91cofactor catabolic process (GO:0051187)3.49406758
92negative regulation of myeloid cell apoptotic process (GO:0033033)3.48300495
93benzene-containing compound metabolic process (GO:0042537)3.45637890
94protein-lipid complex assembly (GO:0065005)3.44529226
95arginine metabolic process (GO:0006525)3.44067099
96epoxygenase P450 pathway (GO:0019373)3.42876499
97negative regulation of interleukin-12 production (GO:0032695)3.42334056
98indolalkylamine metabolic process (GO:0006586)3.42069257
99cholesterol homeostasis (GO:0042632)3.41195734
100acetyl-CoA metabolic process (GO:0006084)3.40614369
101fatty acid beta-oxidation (GO:0006635)3.39142210
102fatty acid oxidation (GO:0019395)3.39053059
103immunoglobulin mediated immune response (GO:0016064)3.38619504
104acute-phase response (GO:0006953)3.38510410
105sterol homeostasis (GO:0055092)3.37518842
106phospholipid homeostasis (GO:0055091)3.36947123
107macrophage activation involved in immune response (GO:0002281)3.36108134
108carboxylic acid catabolic process (GO:0046395)3.35477009
109organic acid catabolic process (GO:0016054)3.35477009
110lipoprotein metabolic process (GO:0042157)3.34355425
1112-oxoglutarate metabolic process (GO:0006103)3.33520922
112short-chain fatty acid metabolic process (GO:0046459)3.32933506
113intestinal cholesterol absorption (GO:0030299)3.32689027
114lipid oxidation (GO:0034440)3.31447186
115activation of MAPKKK activity (GO:0000185)3.31017915
116plasma lipoprotein particle organization (GO:0071827)3.30367688
117ketone body metabolic process (GO:1902224)3.30187260
118positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.29598215
119monocarboxylic acid catabolic process (GO:0072329)3.25770210
120positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.24469449
121complement activation, classical pathway (GO:0006958)3.23890950
122interferon-gamma-mediated signaling pathway (GO:0060333)3.23167318
123positive regulation of interferon-alpha production (GO:0032727)3.22744411
124germinal center formation (GO:0002467)3.22235383
125positive regulation by symbiont of host defense response (GO:0052509)3.21970727
126modulation by symbiont of host defense response (GO:0052031)3.21970727
127modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.21970727
128modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.21970727
129positive regulation by organism of defense response of other organism involved in symbiotic interact3.21970727
130modulation by symbiont of host immune response (GO:0052553)3.21970727
131myeloid dendritic cell activation (GO:0001773)3.21446822
132regulation of type I interferon-mediated signaling pathway (GO:0060338)3.17587191
133regulation of vitamin metabolic process (GO:0030656)3.15778551
134omega-hydroxylase P450 pathway (GO:0097267)3.14158867
135positive regulation of gamma-delta T cell activation (GO:0046645)3.11748149
136regulation of interferon-beta biosynthetic process (GO:0045357)3.09009222
137positive regulation of humoral immune response (GO:0002922)3.04803411
138positive regulation of chemokine biosynthetic process (GO:0045080)3.04644739
139regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.03299396
140regulation of interferon-gamma biosynthetic process (GO:0045072)3.03168732
141dendritic cell differentiation (GO:0097028)3.00621075
142T cell lineage commitment (GO:0002360)2.95712644
143negative regulation of cytokine production involved in immune response (GO:0002719)2.95545799
144response to muramyl dipeptide (GO:0032495)2.90477345
145regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.90126236
146regulation of mononuclear cell migration (GO:0071675)2.88538168
147regulation of dendritic cell antigen processing and presentation (GO:0002604)2.87174954
148regulation of chronic inflammatory response (GO:0002676)2.86685170
149negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.85715858
150glycosphingolipid catabolic process (GO:0046479)2.85667372
151response to protozoan (GO:0001562)2.84443097
152complement activation (GO:0006956)2.79943946
153modulation by symbiont of host cellular process (GO:0044068)2.78840224
154regulation of podosome assembly (GO:0071801)2.77327040
155detection of molecule of bacterial origin (GO:0032490)2.77067204
156positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.76627062
157defense response to protozoan (GO:0042832)2.75950311
158positive regulation of fatty acid biosynthetic process (GO:0045723)2.68770885
159positive regulation of type 2 immune response (GO:0002830)2.64424162
160cellular response to arsenic-containing substance (GO:0071243)2.63736193
161oligosaccharide catabolic process (GO:0009313)2.63729455
162regulation of macrophage chemotaxis (GO:0010758)2.61672434
163cellular response to interferon-gamma (GO:0071346)2.61262414
164regulation of chemokine biosynthetic process (GO:0045073)2.61244652
165negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.61080183
166adhesion of symbiont to host (GO:0044406)2.59600155
167positive regulation of immunoglobulin mediated immune response (GO:0002891)2.59198568
168positive regulation of B cell mediated immunity (GO:0002714)2.59198568
169N-acetylneuraminate metabolic process (GO:0006054)2.58571043
170response to thyroid hormone (GO:0097066)2.57294175
171protein activation cascade (GO:0072376)2.57189483
172detection of bacterium (GO:0016045)2.56241038
173regulation of heterotypic cell-cell adhesion (GO:0034114)2.55979263
174regulation of interleukin-12 production (GO:0032655)2.55605366
175regulation of immunoglobulin secretion (GO:0051023)2.55554579

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.21894950
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.31834214
3LXR_22158963_ChIP-Seq_LIVER_Mouse5.63738832
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.59551688
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.80218624
6IRF8_22096565_ChIP-ChIP_GC-B_Human4.56888562
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.43023864
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.03142935
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.61235092
10MYC_22102868_ChIP-Seq_BL_Human3.26962142
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.17530135
12IRF8_21731497_ChIP-ChIP_J774_Mouse3.14433856
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.89558688
14* VDR_21846776_ChIP-Seq_THP-1_Human2.88824743
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.78799661
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.65276448
17* IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.48370938
18CLOCK_20551151_ChIP-Seq_293T_Human2.47687948
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.30933326
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30651806
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25216607
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.20233805
23* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.07441795
24VDR_24763502_ChIP-Seq_THP-1_Human2.05122948
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.0620366
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.98928458
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.98729216
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.87796248
29MAF_26560356_Chip-Seq_TH1_Human1.86764323
30TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.80985018
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.78800412
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.78796383
33ZNF263_19887448_ChIP-Seq_K562_Human1.75595840
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.67710812
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66572910
36TCF7_22412390_ChIP-Seq_EML_Mouse1.65779050
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64179626
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63507898
39* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.60596876
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59409314
41FOXA2_19822575_ChIP-Seq_HepG2_Human1.56874800
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54805654
43LXR_22292898_ChIP-Seq_THP-1_Human1.47864485
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46221027
45MAF_26560356_Chip-Seq_TH2_Human1.44681227
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.43190731
47TP63_17297297_ChIP-ChIP_HaCaT_Human1.43050167
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42245751
49SPI1_23547873_ChIP-Seq_NB4_Human1.40607354
50ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39229933
51UTX_26944678_Chip-Seq_JUKART_Human1.36756921
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.34754920
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33769198
54* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32569404
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32281820
56SPI1_23127762_ChIP-Seq_K562_Human1.31170971
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.30940916
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27288663
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26515010
60PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26359101
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25177823
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25008947
63NCOR1_26117541_ChIP-Seq_K562_Human1.23878505
64STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23034458
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22314313
66SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22100572
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.21972154
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21567166
69* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19713408
70NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18111029
71HNF4A_19822575_ChIP-Seq_HepG2_Human1.18067097
72MYB_26560356_Chip-Seq_TH1_Human1.18006783
73TFEB_21752829_ChIP-Seq_HELA_Human1.17834566
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16507416
75STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.15582157
76RACK7_27058665_Chip-Seq_MCF-7_Human1.14388839
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13469624
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12857544
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12605081
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11462196
81ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10852357
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10744364
83TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10394255
84BCL6_27268052_Chip-Seq_Bcells_Human1.09007695
85RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08609908
86SCL_19346495_ChIP-Seq_HPC-7_Human1.07798756
87PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07716197
88ATF3_27146783_Chip-Seq_COLON_Human1.06819097
89CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06365568
90CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05148739
91MYB_26560356_Chip-Seq_TH2_Human1.03469255
92SA1_27219007_Chip-Seq_ERYTHROID_Human1.02843984
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01535736
94PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00284806
95ELK3_25401928_ChIP-Seq_HUVEC_Human0.99216223
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98323453
97RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98312326
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96684263
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96522676
100GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95987009
101GATA1_22025678_ChIP-Seq_K562_Human0.95347837
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94794301
103ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94729510
104P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94726739
105TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94065878
106P68_20966046_ChIP-Seq_HELA_Human0.93885964
107VDR_24787735_ChIP-Seq_THP-1_Human0.93540211
108SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92917993
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92336692
110SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89547520
111TBX20_22328084_ChIP-Seq_HEART_Mouse0.86971339
112TBX20_22080862_ChIP-Seq_HEART_Mouse0.86971339
113KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85379694
114NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.84443572
115PPAR_26484153_Chip-Seq_NCI-H1993_Human0.83587871
116RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.82991029
117CREB1_26743006_Chip-Seq_LNCaP_Human0.82961817
118TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82726992
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.82371702
120GATA4_25053715_ChIP-Seq_YYC3_Human0.81881371
121STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80139998
122ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78306108
123GATA1_19941826_ChIP-Seq_K562_Human0.77497801
124ESR1_21235772_ChIP-Seq_MCF-7_Human0.76522635
125NFIB_24661679_ChIP-Seq_LUNG_Mouse0.75742735
126CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.75665897
127FOXO3_23340844_ChIP-Seq_DLD1_Human0.75600555
128RARB_24833708_ChIP-Seq_LIVER_Mouse0.75034840
129RARA_24833708_ChIP-Seq_LIVER_Mouse0.74191813
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.74134692
131NRF2_20460467_ChIP-Seq_MEFs_Mouse0.73542491
132NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.73542491
133FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.71930843
134SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.70598836
135KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.69972423
136FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.69965071
137KDM2B_26808549_Chip-Seq_SUP-B15_Human0.69696187
138GATA6_25053715_ChIP-Seq_YYC3_Human0.68600082
139KDM2B_26808549_Chip-Seq_K562_Human0.68405735
140ERG_21242973_ChIP-ChIP_JURKAT_Human0.67360710
141HIF1A_21447827_ChIP-Seq_MCF-7_Human0.67042198
142UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.66237843
143ESR1_20079471_ChIP-ChIP_T-47D_Human0.66050579
144AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.64847400
145BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.64609948
146BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64196552
147SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.64114464
148RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63497681
149SALL4_18804426_ChIP-ChIP_XEN_Mouse0.62562096
150KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.62181907
151GATA2_19941826_ChIP-Seq_K562_Human0.61155015
152P63_26484246_Chip-Seq_KERATINOCYTES_Human0.60931190
153GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.60040730
154PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.59617965
155GATA3_24758297_ChIP-Seq_MCF-7_Human0.59511453
156PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.59259290
157HTT_18923047_ChIP-ChIP_STHdh_Human0.58542247
158TET1_21451524_ChIP-Seq_MESCs_Mouse0.58422983
159KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.58109754
160EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.57501777
161SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.56333102
162SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.56246678
163KDM2B_26808549_Chip-Seq_DND41_Human0.55681791
164BCOR_27268052_Chip-Seq_Bcells_Human0.55249788
165GATA1_19941827_ChIP-Seq_MEL_Mouse0.55240647

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.21650728
2MP0005360_urolithiasis6.20531321
3MP0005365_abnormal_bile_salt5.50308901
4MP0005085_abnormal_gallbladder_physiolo5.37350382
5MP0003303_peritoneal_inflammation4.42331982
6MP0008875_abnormal_xenobiotic_pharmacok4.16799147
7MP0003252_abnormal_bile_duct3.80068135
8MP0003806_abnormal_nucleotide_metabolis3.70016264
9MP0009840_abnormal_foam_cell3.36611233
10MP0010329_abnormal_lipoprotein_level3.24931527
11MP0003705_abnormal_hypodermis_morpholog3.09686046
12MP0005083_abnormal_biliary_tract3.02938487
13MP0003436_decreased_susceptibility_to2.92684838
14MP0009785_altered_susceptibility_to2.90202722
15MP0000685_abnormal_immune_system2.77413128
16MP0001835_abnormal_antigen_presentation2.75891493
17MP0003195_calcinosis2.74293122
18MP0001790_abnormal_immune_system2.71034308
19MP0005387_immune_system_phenotype2.71034308
20MP0002148_abnormal_hypersensitivity_rea2.64296711
21MP0008438_abnormal_cutaneous_collagen2.55957137
22MP0005000_abnormal_immune_tolerance2.53137226
23MP0004510_myositis2.46084851
24MP0005671_abnormal_response_to2.35118522
25MP0001666_abnormal_nutrient_absorption2.31491251
26MP0005332_abnormal_amino_acid2.28413807
27MP0006082_CNS_inflammation2.28315353
28MP0003191_abnormal_cellular_cholesterol2.25856964
29MP0005025_abnormal_response_to2.21445445
30MP0001800_abnormal_humoral_immune2.20078477
31MP0000609_abnormal_liver_physiology2.05422173
32MP0002419_abnormal_innate_immunity2.04328487
33MP0002118_abnormal_lipid_homeostasis1.98680769
34MP0002452_abnormal_antigen_presenting1.97794191
35MP0002723_abnormal_immune_serum1.94635908
36MP0003172_abnormal_lysosome_physiology1.74587916
37MP0004947_skin_inflammation1.71899227
38MP0005319_abnormal_enzyme/_coenzyme1.67346948
39MP0009278_abnormal_bone_marrow1.63144777
40MP0002138_abnormal_hepatobiliary_system1.63112996
41MP0003868_abnormal_feces_composition1.62861929
42MP0001845_abnormal_inflammatory_respons1.60951247
43MP0001853_heart_inflammation1.60521573
44MP0005397_hematopoietic_system_phenotyp1.59476793
45MP0001545_abnormal_hematopoietic_system1.59476793
46MP0009333_abnormal_splenocyte_physiolog1.58845992
47MP0002420_abnormal_adaptive_immunity1.56136004
48MP0001819_abnormal_immune_cell1.56038676
49MP0003075_altered_response_to1.53981395
50MP0005310_abnormal_salivary_gland1.53662685
51MP0010155_abnormal_intestine_physiology1.53180510
52MP0005275_abnormal_skin_tensile1.51773878
53MP0004019_abnormal_vitamin_homeostasis1.50893401
54MP0000343_altered_response_to1.45033235
55MP0001533_abnormal_skeleton_physiology1.43183144
56MP0003724_increased_susceptibility_to1.36656206
57MP0002405_respiratory_system_inflammati1.33947774
58MP0000716_abnormal_immune_system1.27911569
59MP0005584_abnormal_enzyme/coenzyme_acti1.27376808
60MP0000858_altered_metastatic_potential1.27145429
61MP0002398_abnormal_bone_marrow1.24345240
62MP0005464_abnormal_platelet_physiology1.23626871
63MP0005670_abnormal_white_adipose1.23096260
64MP0002998_abnormal_bone_remodeling1.19563405
65MP0002837_dystrophic_cardiac_calcinosis1.17709077
66MP0003763_abnormal_thymus_physiology1.17178680
67MP0000598_abnormal_liver_morphology1.17082824
68MP0009643_abnormal_urine_homeostasis1.15614244
69MP0003656_abnormal_erythrocyte_physiolo1.15318911
70MP0005076_abnormal_cell_differentiation1.14712724
71MP0010368_abnormal_lymphatic_system1.13112057
72MP0000689_abnormal_spleen_morphology1.08884793
73MP0002429_abnormal_blood_cell1.07248519
74MP0004130_abnormal_muscle_cell1.06321466
75MP0005220_abnormal_exocrine_pancreas1.05855852
76MP0005451_abnormal_body_composition1.05042061
77MP0002971_abnormal_brown_adipose1.04653642
78MP0003279_aneurysm1.04651414
79MP0005503_abnormal_tendon_morphology0.99461362
80MP0002722_abnormal_immune_system0.99103588
81MP0003186_abnormal_redox_activity0.98086726
82MP0002877_abnormal_melanocyte_morpholog0.96604406
83MP0003448_altered_tumor_morphology0.96512913
84MP0009053_abnormal_anal_canal0.94300997
85MP0003091_abnormal_cell_migration0.94065732
86MP0001873_stomach_inflammation0.93516274
87MP0009384_cardiac_valve_regurgitation0.93396487
88MP0005167_abnormal_blood-brain_barrier0.93162283
89MP0002078_abnormal_glucose_homeostasis0.93089439
90MP0003011_delayed_dark_adaptation0.92871807
91MP0001764_abnormal_homeostasis0.92575222
92MP0002060_abnormal_skin_morphology0.91664849
93MP0005166_decreased_susceptibility_to0.91491132
94MP0000604_amyloidosis0.86968493
95MP0005666_abnormal_adipose_tissue0.86906318
96MP0008874_decreased_physiological_sensi0.85802244
97MP0002254_reproductive_system_inflammat0.85552311
98MP0008004_abnormal_stomach_pH0.83983996
99MP0005334_abnormal_fat_pad0.83962337
100MP0003690_abnormal_glial_cell0.82333876
101MP0001348_abnormal_lacrimal_gland0.79774071
102MP0009763_increased_sensitivity_to0.79602396
103MP0005023_abnormal_wound_healing0.79493026
104MP0004808_abnormal_hematopoietic_stem0.79198730
105MP0004185_abnormal_adipocyte_glucose0.78020018
106MP0003566_abnormal_cell_adhesion0.77930054
107MP0002332_abnormal_exercise_endurance0.76584257
108MP0009642_abnormal_blood_homeostasis0.76134453
109MP0002295_abnormal_pulmonary_circulatio0.75860186
110MP0005084_abnormal_gallbladder_morpholo0.75681767
111MP0001542_abnormal_bone_strength0.74580252
112MP0001243_abnormal_dermal_layer0.74098126
113MP0009697_abnormal_copulation0.73184867
114MP0005375_adipose_tissue_phenotype0.73125285
115MP0005257_abnormal_intraocular_pressure0.72994241
116MP0002168_other_aberrant_phenotype0.72402175
117MP0009764_decreased_sensitivity_to0.72310657
118MP0003300_gastrointestinal_ulcer0.71239012
119MP0002896_abnormal_bone_mineralization0.71213318
120MP0005647_abnormal_sex_gland0.68304191
121MP0009115_abnormal_fat_cell0.66337848
122MP0000003_abnormal_adipose_tissue0.66256079
123MP0001663_abnormal_digestive_system0.65917520
124MP0010307_abnormal_tumor_latency0.65897817
125MP0001984_abnormal_olfaction0.63601387
126MP0008260_abnormal_autophagy0.63453856
127MP0002928_abnormal_bile_duct0.63020049
128MP0005164_abnormal_response_to0.62615268
129MP0000371_diluted_coat_color0.62582699
130MP0005636_abnormal_mineral_homeostasis0.62536697
131MP0005448_abnormal_energy_balance0.62426113
132MP0004272_abnormal_basement_membrane0.62356142
133MP0006036_abnormal_mitochondrial_physio0.62018023
134MP0003183_abnormal_peptide_metabolism0.61749455
135MP0008469_abnormal_protein_level0.60049461
136MP0005376_homeostasis/metabolism_phenot0.60002741
137MP0000249_abnormal_blood_vessel0.59598161
138MP0002970_abnormal_white_adipose0.59593095
139MP0001944_abnormal_pancreas_morphology0.57180853
140MP0001756_abnormal_urination0.56657763
141MP0005058_abnormal_lysosome_morphology0.55784227
142MP0002269_muscular_atrophy0.54713102
143MP0003329_amyloid_beta_deposits0.53572335
144MP0000013_abnormal_adipose_tissue0.53520910
145MP0000639_abnormal_adrenal_gland0.52752417
146MP0001661_extended_life_span0.52504645
147MP0005535_abnormal_body_temperature0.51965220
148MP0005248_abnormal_Harderian_gland0.51891102
149MP0005395_other_phenotype0.49708224
150MP0002796_impaired_skin_barrier0.48649757
151MP0005330_cardiomyopathy0.47997345
152MP0003453_abnormal_keratinocyte_physiol0.45453036
153MP0005266_abnormal_metabolism0.45354584
154MP0003283_abnormal_digestive_organ0.45342409
155MP0009765_abnormal_xenobiotic_induced0.44605096
156MP0005408_hypopigmentation0.44319605
157MP0001958_emphysema0.43694988
158MP0005623_abnormal_meninges_morphology0.42952983
159MP0006054_spinal_hemorrhage0.42730938
160MP0005508_abnormal_skeleton_morphology0.42705100
161MP0002108_abnormal_muscle_morphology0.42568889
162MP0000767_abnormal_smooth_muscle0.42095059

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.88791492
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.37208358
3Intrahepatic cholestasis (HP:0001406)5.90130242
4Xanthomatosis (HP:0000991)5.86278693
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.65422128
6Hypobetalipoproteinemia (HP:0003563)5.18532810
7Prolonged partial thromboplastin time (HP:0003645)5.11294547
8Hyperlipoproteinemia (HP:0010980)4.96129242
9Abnormality of glycolipid metabolism (HP:0010969)4.60252476
10Abnormality of liposaccharide metabolism (HP:0010968)4.60252476
11Abnormality of glycosphingolipid metabolism (HP:0004343)4.60252476
12Complement deficiency (HP:0004431)4.40825755
13Glomerulonephritis (HP:0000099)4.33381038
14Hypolipoproteinemia (HP:0010981)4.28931933
15Hypoalphalipoproteinemia (HP:0003233)4.17594859
16Abnormality of the common coagulation pathway (HP:0010990)4.01120577
17Ketosis (HP:0001946)4.00727899
18Hypoglycemic coma (HP:0001325)3.98110677
19Hyperammonemia (HP:0001987)3.95256471
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.88757572
21Epidermoid cyst (HP:0200040)3.85661663
22Gastrointestinal stroma tumor (HP:0100723)3.83794105
23Recurrent gram-negative bacterial infections (HP:0005420)3.81901326
24Hyperglycinemia (HP:0002154)3.77634772
25Joint hemorrhage (HP:0005261)3.72534927
26Protrusio acetabuli (HP:0003179)3.63124726
27Abnormality of the intrinsic pathway (HP:0010989)3.54458078
28Abnormality of glutamine family amino acid metabolism (HP:0010902)3.50216371
29Abnormality of sulfur amino acid metabolism (HP:0004339)3.48997795
30Abnormality of complement system (HP:0005339)3.36607849
31Abnormality of glycine metabolism (HP:0010895)3.33821443
32Abnormality of serine family amino acid metabolism (HP:0010894)3.33821443
33Abnormality of macrophages (HP:0004311)3.31287875
34Hyperglycinuria (HP:0003108)3.30816432
35Premature rupture of membranes (HP:0001788)3.28000740
36Dysostosis multiplex (HP:0000943)3.27736970
37Vacuolated lymphocytes (HP:0001922)3.26858455
38Fat malabsorption (HP:0002630)3.23935861
39Increased cerebral lipofuscin (HP:0011813)3.20094768
40Ketoacidosis (HP:0001993)3.16291407
41Mediastinal lymphadenopathy (HP:0100721)3.15348731
42Myocardial infarction (HP:0001658)3.12016267
43Increased serum ferritin (HP:0003281)3.11056320
44Abnormality of methionine metabolism (HP:0010901)3.10205278
45Hypercholesterolemia (HP:0003124)3.09353652
46Abnormality of aspartate family amino acid metabolism (HP:0010899)3.09272472
47Peritonitis (HP:0002586)3.02596669
48Recurrent abscess formation (HP:0002722)3.01996925
49Skin nodule (HP:0200036)3.00235296
50Recurrent bacterial skin infections (HP:0005406)2.99345724
51Abnormality of fatty-acid metabolism (HP:0004359)2.96496826
52Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.94819701
53Loss of speech (HP:0002371)2.87073950
54Eczematoid dermatitis (HP:0000976)2.86820031
55Emphysema (HP:0002097)2.86818950
56Optic neuritis (HP:0100653)2.85344472
57Retrobulbar optic neuritis (HP:0100654)2.85344472
58Meningitis (HP:0001287)2.84859475
59Orchitis (HP:0100796)2.81869854
60Purpura (HP:0000979)2.81048941
61Hyperbilirubinemia (HP:0002904)2.78423341
62Vasculitis (HP:0002633)2.74148142
63Hepatocellular carcinoma (HP:0001402)2.74100773
64Recurrent viral infections (HP:0004429)2.72947093
65Nephritis (HP:0000123)2.68941742
66Increased neuronal autofluorescent lipopigment (HP:0002074)2.67883934
67Autoimmune thrombocytopenia (HP:0001973)2.67167625
68Conjugated hyperbilirubinemia (HP:0002908)2.65644930
69Abnormality of mucopolysaccharide metabolism (HP:0011020)2.56857037
70Abnormality of polysaccharide metabolism (HP:0011012)2.56857037
71Abnormality of glycosaminoglycan metabolism (HP:0004371)2.56857037
72Cholelithiasis (HP:0001081)2.55833218
73Disinhibition (HP:0000734)2.54824030
74Abnormality of pyrimidine metabolism (HP:0004353)2.54311449
75Abnormal gallbladder morphology (HP:0012437)2.53840175
76Hypochromic microcytic anemia (HP:0004840)2.53275071
77Mitral stenosis (HP:0001718)2.48204983
78Colitis (HP:0002583)2.47320439
79Urinary glycosaminoglycan excretion (HP:0003541)2.46357636
80Mucopolysacchariduria (HP:0008155)2.46357636
81IgA deficiency (HP:0002720)2.44773150
82Cholecystitis (HP:0001082)2.42907555
83Abnormal gallbladder physiology (HP:0012438)2.42907555
84Abnormality of nucleobase metabolism (HP:0010932)2.42756050
85Hypoglycemic seizures (HP:0002173)2.42438301
86Late onset (HP:0003584)2.39655335
87Abnormality of serum amino acid levels (HP:0003112)2.37471365
88Spontaneous abortion (HP:0005268)2.37338935
89Abnormality of purine metabolism (HP:0004352)2.36978351
90Delayed CNS myelination (HP:0002188)2.34575547
91Amyloidosis (HP:0011034)2.32198863
92Abnormality of the Achilles tendon (HP:0005109)2.31883765
93Metabolic acidosis (HP:0001942)2.31368796
94Steatorrhea (HP:0002570)2.31177734
95Hypertensive crisis (HP:0100735)2.29997529
96Myositis (HP:0100614)2.29530809
97Abnormal cartilage morphology (HP:0002763)2.28746411
98Obstructive lung disease (HP:0006536)2.28389901
99Chronic obstructive pulmonary disease (HP:0006510)2.28389901
100Pulmonary infiltrates (HP:0002113)2.28338816
101Cardiovascular calcification (HP:0011915)2.28303911
102Hyperinsulinemic hypoglycemia (HP:0000825)2.25655365
103Neonatal onset (HP:0003623)2.25509260
104Cellulitis (HP:0100658)2.24463757
105Vascular calcification (HP:0004934)2.22096381
106Turricephaly (HP:0000262)2.22091550
107Gangrene (HP:0100758)2.21721291
108Hemorrhage of the eye (HP:0011885)2.20363849
109Abnormality of dicarboxylic acid metabolism (HP:0010995)2.20025163
110Dicarboxylic aciduria (HP:0003215)2.20025163
111Back pain (HP:0003418)2.16984567
112Nuclear cataract (HP:0100018)2.16953918
113Spastic diplegia (HP:0001264)2.15054225
114Increased IgM level (HP:0003496)2.15044355
115Gout (HP:0001997)2.11346867
116Agammaglobulinemia (HP:0004432)2.08465221
117Thoracic kyphosis (HP:0002942)2.07040606
118Thrombophlebitis (HP:0004418)2.06903264
119Esophageal varix (HP:0002040)2.06707945
120Increased IgE level (HP:0003212)2.06534564
121Restrictive lung disease (HP:0002091)2.05536852
122Joint swelling (HP:0001386)2.05293729
123Hyperglycemia (HP:0003074)2.04719231
124Lymphopenia (HP:0001888)2.04204064
125Recurrent sinusitis (HP:0011108)2.03623528
126Ectopia lentis (HP:0001083)2.03178692
127Malnutrition (HP:0004395)2.02649353
128Axonal loss (HP:0003447)2.02288160
129Abnormality of the gallbladder (HP:0005264)2.01890039
130Elevated alkaline phosphatase (HP:0003155)2.01211956
131Recurrent skin infections (HP:0001581)2.01090324
132Systemic lupus erythematosus (HP:0002725)2.00782905
133Hydroxyprolinuria (HP:0003080)1.99824088
134Abnormality of proline metabolism (HP:0010907)1.99824088
135Recurrent fungal infections (HP:0002841)1.99377163
136Bone pain (HP:0002653)1.96964755
137Lethargy (HP:0001254)1.96335772
138Menorrhagia (HP:0000132)1.95492636
139Abnormal delivery (HP:0001787)1.95332757
140Thin bony cortex (HP:0002753)1.95120001
141Reticulocytosis (HP:0001923)1.94196049
142Abnormality of cells of the lymphoid lineage (HP:0012140)1.93961512
143Pulmonary embolism (HP:0002204)1.93463120
144Poikilocytosis (HP:0004447)1.92162377
145Keratoconjunctivitis sicca (HP:0001097)1.90986590
146Prolonged neonatal jaundice (HP:0006579)1.90784212
147Acanthocytosis (HP:0001927)1.90537016
148Arterial thrombosis (HP:0004420)1.90471220
149Recurrent lower respiratory tract infections (HP:0002783)1.88768200
150Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.88515260
151Neurofibrillary tangles (HP:0002185)1.88487628
152Irritability (HP:0000737)1.87293978
153Pancreatitis (HP:0001733)1.86992531
154Acrocyanosis (HP:0001063)1.86628462
155Biconcave vertebral bodies (HP:0004586)1.85986064
156Abnormality of iron homeostasis (HP:0011031)1.85391921
157Mitral valve prolapse (HP:0001634)1.84898145
158Recurrent bronchitis (HP:0002837)1.84546014
159Nonimmune hydrops fetalis (HP:0001790)1.83411799
160Arthralgia (HP:0002829)1.82889122
161Mutism (HP:0002300)1.82846623
162Polycythemia (HP:0001901)1.82641009
163Progressive neurologic deterioration (HP:0002344)1.81720282
164Recurrent pneumonia (HP:0006532)1.80828360
165Abnormality of alkaline phosphatase activity (HP:0004379)1.80648781
166Hemoptysis (HP:0002105)1.79533628
167Abnormality of transition element cation homeostasis (HP:0011030)1.78830424
168Sensorimotor neuropathy (HP:0007141)1.78041978
169Opisthotonus (HP:0002179)1.75781097
170Broad metatarsal (HP:0001783)1.75204570
171Myoglobinuria (HP:0002913)1.72814566
172Gingival bleeding (HP:0000225)1.72206614
173Achilles tendon contracture (HP:0001771)1.70284126
174Vomiting (HP:0002013)1.70226103

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.40818973
2TRIB35.21594008
3IRAK34.46439826
4BCKDK4.42255073
5PRPF4B3.84739364
6SIK13.80742329
7PKN23.75252494
8NME23.74885563
9MAP3K143.11948152
10FGFR42.87216962
11MAP4K12.72822913
12RIPK42.70707630
13TAOK22.45544092
14SMG12.22264298
15LATS12.19110726
16TAOK32.18132703
17BLK2.07074471
18IRAK42.06191912
19PDGFRA1.97671451
20PTK61.95114537
21IKBKE1.84452899
22IKBKB1.77402393
23MAP3K101.77315399
24RIPK11.77286277
25MATK1.75821105
26INSRR1.72072703
27DDR21.68792932
28LATS21.66358233
29EEF2K1.64999016
30TTN1.62228909
31FLT31.61769169
32GRK71.50299475
33MAP3K131.49740063
34CDK121.46404179
35CHUK1.45532646
36CDC42BPA1.41356458
37JAK31.40415846
38ICK1.38789092
39BMX1.32312291
40SIK21.31987838
41PTK21.25956522
42ERBB41.25188904
43CSF1R1.24499965
44PIK3CG1.16752707
45DYRK1B1.16529972
46MAPK111.15687046
47SIK31.07973474
48MAPK151.07643810
49EPHB11.05432681
50ABL21.04403284
51FGR1.03638289
52MST1R1.00183697
53CAMK1D0.98944766
54MTOR0.98701846
55EPHA30.97042043
56TGFBR20.96384720
57CDK60.96310576
58NEK90.95877162
59EPHB20.95339139
60SYK0.94065586
61MAP2K40.93746878
62PAK30.91939135
63MAP3K70.91916120
64KIT0.91881393
65TBK10.90320893
66MET0.88439098
67FRK0.87724176
68MAP3K30.85619736
69BMPR20.84615003
70MAP2K30.84553792
71STK38L0.83846705
72IRAK20.82005444
73DAPK20.81958015
74PAK20.80764966
75ARAF0.80560867
76LYN0.79313162
77RET0.77527352
78MAP2K10.73970270
79PRKAA20.72850917
80LRRK20.72796454
81MAP3K80.68895087
82JAK10.67159104
83IRAK10.67011930
84FER0.66895114
85JAK20.65056175
86FGFR20.62813142
87ERBB20.62046739
88CAMK1G0.61972324
89PHKG10.61847968
90PHKG20.61847968
91BRAF0.58368140
92KDR0.58329939
93GSK3A0.56834082
94TYK20.56275941
95MAP2K20.55418226
96RPS6KL10.55161798
97RPS6KC10.55161798
98CLK10.54237982
99PRKAA10.54182351
100MARK30.54178087
101MAPKAPK30.53728798
102PRKD10.53593607
103BTK0.53194048
104PIM10.52796960
105DAPK30.52488329
106ILK0.51958662
107EPHA20.51856399
108STK100.51569914
109NTRK10.51095595
110STK30.49059986
111FGFR30.48946793
112PRKCH0.48851003
113ZAP700.47631505
114MAP3K10.46233091
115PRKCZ0.45830185
116MAP3K110.45409662
117CAMKK10.44683052
118TESK20.44493888
119PAK40.43458637
120MAPK120.43422978
121CAMK2G0.42835572
122PIM20.42762608
123MAPK70.41878953
124PRKACG0.41515197
125TYRO30.41300452
126RPS6KA20.40532376
127PDPK10.40103688
128CDK90.38706216
129PDK10.38455611
130HIPK20.38051662
131RPS6KB20.37844319
132CSK0.37821461
133PDGFRB0.37737328
134RPS6KA60.37631171
135MAP3K20.37088674
136FGFR10.36993067
137PRKD20.36133750
138RPS6KA40.36037419
139PTK2B0.35961918
140TAOK10.35777211
141MOS0.35578969
142MAPKAPK20.33939313
143LCK0.33775683
144TESK10.32964733
145AKT20.32659355
146MAPK40.32500291
147KSR20.32368873
148PRKD30.30128379
149CDK40.29820993
150MAP3K50.29672694
151PDK30.29374256
152PDK40.29374256
153MARK20.27602849
154GRK60.27381595
155HCK0.25420306
156MELK0.25059691
157ALK0.24801206

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.17555383
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.40964724
3Nitrogen metabolism_Homo sapiens_hsa009103.34927679
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.16070172
5Arginine biosynthesis_Homo sapiens_hsa002202.93030624
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68916772
7Fatty acid degradation_Homo sapiens_hsa000712.62760609
8Complement and coagulation cascades_Homo sapiens_hsa046102.61503023
9Tryptophan metabolism_Homo sapiens_hsa003802.60687607
10Other glycan degradation_Homo sapiens_hsa005112.60591615
11Allograft rejection_Homo sapiens_hsa053302.54542758
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.52856872
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.52766913
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.44749555
15Intestinal immune network for IgA production_Homo sapiens_hsa046722.42879508
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.42443929
17NF-kappa B signaling pathway_Homo sapiens_hsa040642.30191234
18Asthma_Homo sapiens_hsa053102.26661805
19PPAR signaling pathway_Homo sapiens_hsa033202.10922853
20Autoimmune thyroid disease_Homo sapiens_hsa053202.07052623
21Pentose and glucuronate interconversions_Homo sapiens_hsa000402.03482439
22Butanoate metabolism_Homo sapiens_hsa006502.02725081
23Leishmaniasis_Homo sapiens_hsa051402.01013284
24Propanoate metabolism_Homo sapiens_hsa006402.00323093
25Graft-versus-host disease_Homo sapiens_hsa053321.99266888
26Fatty acid metabolism_Homo sapiens_hsa012121.93234149
27Osteoclast differentiation_Homo sapiens_hsa043801.88856847
28Peroxisome_Homo sapiens_hsa041461.88441726
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.84917596
30B cell receptor signaling pathway_Homo sapiens_hsa046621.77216844
31Chemical carcinogenesis_Homo sapiens_hsa052041.75318929
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.74868344
33Histidine metabolism_Homo sapiens_hsa003401.74863427
34Influenza A_Homo sapiens_hsa051641.74771476
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.71968340
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.69424712
37Rheumatoid arthritis_Homo sapiens_hsa053231.64825607
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.64434883
39beta-Alanine metabolism_Homo sapiens_hsa004101.64324002
40Selenocompound metabolism_Homo sapiens_hsa004501.63360668
41Pertussis_Homo sapiens_hsa051331.62840556
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.61465704
43TNF signaling pathway_Homo sapiens_hsa046681.58038461
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.56572491
45Bile secretion_Homo sapiens_hsa049761.55697632
46Caffeine metabolism_Homo sapiens_hsa002321.55412763
47Drug metabolism - other enzymes_Homo sapiens_hsa009831.53468553
48Tuberculosis_Homo sapiens_hsa051521.52967857
49Type I diabetes mellitus_Homo sapiens_hsa049401.52719158
50Sulfur metabolism_Homo sapiens_hsa009201.48864199
51Herpes simplex infection_Homo sapiens_hsa051681.48609708
52Phenylalanine metabolism_Homo sapiens_hsa003601.48377148
53Staphylococcus aureus infection_Homo sapiens_hsa051501.47764591
54Pyruvate metabolism_Homo sapiens_hsa006201.45788023
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44023230
56Primary immunodeficiency_Homo sapiens_hsa053401.41624033
57Retinol metabolism_Homo sapiens_hsa008301.39825851
58Maturity onset diabetes of the young_Homo sapiens_hsa049501.36596625
59Fat digestion and absorption_Homo sapiens_hsa049751.34294807
60Starch and sucrose metabolism_Homo sapiens_hsa005001.32738387
61Tyrosine metabolism_Homo sapiens_hsa003501.31915784
62Measles_Homo sapiens_hsa051621.31409959
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28386267
64Toxoplasmosis_Homo sapiens_hsa051451.27888213
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26656074
66Malaria_Homo sapiens_hsa051441.25617934
67Hepatitis C_Homo sapiens_hsa051601.25385706
68Carbon metabolism_Homo sapiens_hsa012001.24326361
69Biosynthesis of amino acids_Homo sapiens_hsa012301.22568958
70Antigen processing and presentation_Homo sapiens_hsa046121.20604337
71Cysteine and methionine metabolism_Homo sapiens_hsa002701.19978537
72African trypanosomiasis_Homo sapiens_hsa051431.17938513
73Viral myocarditis_Homo sapiens_hsa054161.17477184
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14963968
75Sulfur relay system_Homo sapiens_hsa041221.13937248
76Folate biosynthesis_Homo sapiens_hsa007901.13245369
77ABC transporters_Homo sapiens_hsa020101.12802285
78Fatty acid elongation_Homo sapiens_hsa000621.12623245
79Hepatitis B_Homo sapiens_hsa051611.07309076
80Acute myeloid leukemia_Homo sapiens_hsa052211.07294383
81Cyanoamino acid metabolism_Homo sapiens_hsa004601.01613305
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98797269
83Arginine and proline metabolism_Homo sapiens_hsa003300.98620986
84Legionellosis_Homo sapiens_hsa051340.98228527
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96971832
86Steroid biosynthesis_Homo sapiens_hsa001000.96162347
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92090728
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91683476
89Lysine degradation_Homo sapiens_hsa003100.90389073
90Apoptosis_Homo sapiens_hsa042100.89973623
91Epstein-Barr virus infection_Homo sapiens_hsa051690.88161324
92Systemic lupus erythematosus_Homo sapiens_hsa053220.83868973
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83605869
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.81756137
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79659448
96One carbon pool by folate_Homo sapiens_hsa006700.77284046
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76141850
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75654391
99Salmonella infection_Homo sapiens_hsa051320.74719731
100Vitamin B6 metabolism_Homo sapiens_hsa007500.70035083
101Hematopoietic cell lineage_Homo sapiens_hsa046400.69195693
102Phagosome_Homo sapiens_hsa041450.66618847
103Glycerolipid metabolism_Homo sapiens_hsa005610.65910510
104Fatty acid biosynthesis_Homo sapiens_hsa000610.64290093
105Vitamin digestion and absorption_Homo sapiens_hsa049770.63657933
106Prolactin signaling pathway_Homo sapiens_hsa049170.63014812
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62872198
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60047060
109Chronic myeloid leukemia_Homo sapiens_hsa052200.59266455
110Insulin resistance_Homo sapiens_hsa049310.59245306
111Glutathione metabolism_Homo sapiens_hsa004800.54222929
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53767541
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.53765125
114Chemokine signaling pathway_Homo sapiens_hsa040620.53277602
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53234526
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51536844
117Shigellosis_Homo sapiens_hsa051310.50380674
118Prion diseases_Homo sapiens_hsa050200.48802978
119Pentose phosphate pathway_Homo sapiens_hsa000300.47384493
120HTLV-I infection_Homo sapiens_hsa051660.44103477
121Sphingolipid metabolism_Homo sapiens_hsa006000.43982173
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43343056
123Pancreatic cancer_Homo sapiens_hsa052120.42442535
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42358327
125Viral carcinogenesis_Homo sapiens_hsa052030.41568467
126T cell receptor signaling pathway_Homo sapiens_hsa046600.40836000
127VEGF signaling pathway_Homo sapiens_hsa043700.35896509
128Glucagon signaling pathway_Homo sapiens_hsa049220.35391326
129Galactose metabolism_Homo sapiens_hsa000520.34703544
130Bladder cancer_Homo sapiens_hsa052190.33640452
131Metabolic pathways_Homo sapiens_hsa011000.33073990
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32819052
133AMPK signaling pathway_Homo sapiens_hsa041520.32390424
134Insulin signaling pathway_Homo sapiens_hsa049100.21740073
135Fructose and mannose metabolism_Homo sapiens_hsa000510.20518809
136Amoebiasis_Homo sapiens_hsa051460.19336423
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.17708640
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16953511
139alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16949254
140ECM-receptor interaction_Homo sapiens_hsa045120.16703126
141Protein digestion and absorption_Homo sapiens_hsa049740.15521945
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.13364921
143Linoleic acid metabolism_Homo sapiens_hsa005910.07577849
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.07394272
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.07159925
146Glycosaminoglycan degradation_Homo sapiens_hsa005310.06369580
147Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.03965582
148Ovarian steroidogenesis_Homo sapiens_hsa049130.03709984
149Thyroid hormone synthesis_Homo sapiens_hsa049180.02015658
150Type II diabetes mellitus_Homo sapiens_hsa04930-0.0876997
151mTOR signaling pathway_Homo sapiens_hsa04150-0.0798517
152Lysosome_Homo sapiens_hsa04142-0.0726673
153Proteoglycans in cancer_Homo sapiens_hsa05205-0.0614224
154Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0446277
155Focal adhesion_Homo sapiens_hsa04510-0.0108642
156Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0046501
157Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0034428

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