ATE1-AS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of synaptic transmission, dopaminergic (GO:0032226)9.60013963
2positive regulation of catecholamine secretion (GO:0033605)7.68832823
3potassium ion export (GO:0071435)6.35292062
4epithelial cilium movement (GO:0003351)5.60366447
5behavioral response to nicotine (GO:0035095)5.51841543
6axonemal dynein complex assembly (GO:0070286)5.25856459
7motile cilium assembly (GO:0044458)5.02481932
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.86288748
9membrane repolarization during action potential (GO:0086011)4.70630876
10regulation of dopamine secretion (GO:0014059)4.68722788
11sperm motility (GO:0030317)4.64957616
12cilium movement (GO:0003341)4.57184805
13cranial nerve morphogenesis (GO:0021602)4.46757612
14acrosome assembly (GO:0001675)4.41406806
15regulation of phosphoprotein phosphatase activity (GO:0043666)4.34919543
16relaxation of smooth muscle (GO:0044557)4.34138138
17regulation of autophagic vacuole assembly (GO:2000785)4.33296849
18activation of protein kinase B activity (GO:0032148)4.23588977
19membrane repolarization (GO:0086009)3.92762570
20cGMP-mediated signaling (GO:0019934)3.90589134
21spermatid development (GO:0007286)3.87472987
22acrosome reaction (GO:0007340)3.80477236
23DNA integration (GO:0015074)3.79611381
24cilium or flagellum-dependent cell motility (GO:0001539)3.79611035
25regulation of oxidative stress-induced neuron death (GO:1903203)3.78314972
26multicellular organism reproduction (GO:0032504)3.67992884
27regulation of synaptic transmission, dopaminergic (GO:0032225)3.66681915
28spermatid nucleus differentiation (GO:0007289)3.61785494
29regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.60795844
30regulation of vacuole organization (GO:0044088)3.60192489
31DNA double-strand break processing (GO:0000729)3.49183781
32postsynaptic membrane organization (GO:0001941)3.48135249
33chaperone-mediated protein complex assembly (GO:0051131)3.42897532
34type B pancreatic cell development (GO:0003323)3.39163274
35membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.38171465
36presynaptic membrane assembly (GO:0097105)3.37027599
37ventricular system development (GO:0021591)3.36417828
38coenzyme catabolic process (GO:0009109)3.34706873
39protein polyglutamylation (GO:0018095)3.34233795
40N-glycan processing (GO:0006491)3.33245623
41neurotransmitter-gated ion channel clustering (GO:0072578)3.28624580
42auditory behavior (GO:0031223)3.28352077
43male meiosis (GO:0007140)3.20621164
44positive regulation of amine transport (GO:0051954)3.19559974
45L-fucose catabolic process (GO:0042355)3.19305632
46fucose catabolic process (GO:0019317)3.19305632
47L-fucose metabolic process (GO:0042354)3.19305632
48Leydig cell differentiation (GO:0033327)3.17787799
49oligosaccharide biosynthetic process (GO:0009312)3.16139155
50neuron projection extension involved in neuron projection guidance (GO:1902284)3.14087894
51axon extension involved in axon guidance (GO:0048846)3.14087894
52heart valve formation (GO:0003188)3.12256596
53intraciliary transport (GO:0042073)3.09862067
54positive regulation of growth hormone secretion (GO:0060124)3.09686854
55positive regulation of steroid hormone secretion (GO:2000833)3.05397543
56dendritic spine morphogenesis (GO:0060997)3.05041735
57endocrine hormone secretion (GO:0060986)3.02465192
58cellular zinc ion homeostasis (GO:0006882)3.02197312
59positive regulation of mitochondrial fission (GO:0090141)3.01612596
60tongue development (GO:0043586)3.00658223
61regulation of oxidative phosphorylation (GO:0002082)2.99864804
62tryptophan catabolic process (GO:0006569)2.99272696
63indole-containing compound catabolic process (GO:0042436)2.99272696
64indolalkylamine catabolic process (GO:0046218)2.99272696
65cell proliferation in forebrain (GO:0021846)2.99176631
66regulation of synaptic vesicle transport (GO:1902803)2.97928199
67negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.90624629
68negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.81604567
69single fertilization (GO:0007338)2.79087505
70regulation of circadian sleep/wake cycle, sleep (GO:0045187)2.79080527
71regulation of circadian sleep/wake cycle (GO:0042749)2.79080527
72forebrain morphogenesis (GO:0048853)2.78559589
73dentate gyrus development (GO:0021542)2.78422254
74regulation of hydrogen peroxide-induced cell death (GO:1903205)2.77956216
75presynaptic membrane organization (GO:0097090)2.74554237
76TOR signaling (GO:0031929)2.74365851
77binding of sperm to zona pellucida (GO:0007339)2.72932328
78L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.66067771
79protein localization to synapse (GO:0035418)2.63924376
80organic cation transport (GO:0015695)2.63545273
81nucleosome disassembly (GO:0006337)2.62537698
82protein-DNA complex disassembly (GO:0032986)2.62537698
83regulation of action potential (GO:0098900)2.61744117
84neuromuscular synaptic transmission (GO:0007274)2.60462702
85positive regulation of glycolytic process (GO:0045821)2.59088988
86sperm-egg recognition (GO:0035036)2.58877644
87regulation of synapse structural plasticity (GO:0051823)2.58541342
88negative regulation of organelle assembly (GO:1902116)2.58312918
89regulation of catecholamine secretion (GO:0050433)2.57578877
90pyrimidine nucleobase catabolic process (GO:0006208)2.57392964
91androgen biosynthetic process (GO:0006702)2.53851429
92receptor recycling (GO:0001881)2.50795033
93neuron fate determination (GO:0048664)2.50702329
94negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.50339797
95negative regulation of response to reactive oxygen species (GO:1901032)2.49750362
96calcium ion-dependent exocytosis (GO:0017156)2.49539658
97negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.46859710
98growth hormone secretion (GO:0030252)2.46472380
99ganglion development (GO:0061548)2.45896969
100regulation of phospholipase A2 activity (GO:0032429)2.44200762

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.96515530
2IGF1R_20145208_ChIP-Seq_DFB_Human4.02730054
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.74789945
4EZH2_22144423_ChIP-Seq_EOC_Human3.56817297
5GBX2_23144817_ChIP-Seq_PC3_Human3.47858378
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.12761771
7VDR_22108803_ChIP-Seq_LS180_Human2.71978907
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.64508826
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37410696
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.36167637
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35576862
12FUS_26573619_Chip-Seq_HEK293_Human2.18433206
13ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.15619166
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10006749
15POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.04739192
16TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04739192
17ZNF274_21170338_ChIP-Seq_K562_Hela1.96648826
18AR_21572438_ChIP-Seq_LNCaP_Human1.87547990
19CBX2_27304074_Chip-Seq_ESCs_Mouse1.84688846
20HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.75009266
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72280161
22CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.70835509
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.70449906
24ER_23166858_ChIP-Seq_MCF-7_Human1.70180936
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.66704507
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.66648561
27P300_19829295_ChIP-Seq_ESCs_Human1.66185947
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.65091284
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57692037
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57664331
31ARNT_22903824_ChIP-Seq_MCF-7_Human1.53495229
32EWS_26573619_Chip-Seq_HEK293_Human1.53302940
33SMAD4_21799915_ChIP-Seq_A2780_Human1.53297363
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.51888554
35SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50313539
36VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.48799978
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48084925
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45430501
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.43651738
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41737948
41WDR5_24793694_ChIP-Seq_LNCAP_Human1.41084426
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40597877
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40597877
44IRF1_19129219_ChIP-ChIP_H3396_Human1.40497854
45AHR_22903824_ChIP-Seq_MCF-7_Human1.38542638
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.38367000
47KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36947041
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.33777788
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33409548
50P53_22127205_ChIP-Seq_FIBROBLAST_Human1.33051148
51RXR_22108803_ChIP-Seq_LS180_Human1.32121327
52BCAT_22108803_ChIP-Seq_LS180_Human1.31598482
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29759421
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29695168
55ERA_21632823_ChIP-Seq_H3396_Human1.29533731
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.29470488
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26561332
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24622745
59TBL1_22424771_ChIP-Seq_293T_Human1.24303345
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23194725
61CBP_20019798_ChIP-Seq_JUKART_Human1.23131463
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23131463
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22777994
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22347072
65MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21497919
66SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20864462
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18928776
68SMAD4_21741376_ChIP-Seq_EPCs_Human1.18479242
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17469259
70RUNX2_22187159_ChIP-Seq_PCA_Human1.17071816
71STAT3_23295773_ChIP-Seq_U87_Human1.14423793
72REST_18959480_ChIP-ChIP_MESCs_Mouse1.14294393
73MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.11362483
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11274154
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10979914
76ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10206708
77SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09008607
78MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08731622
79SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08646581
80OCT1_27270436_Chip-Seq_PROSTATE_Human1.06547756
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05408818
82REST_21632747_ChIP-Seq_MESCs_Mouse1.04239244
83AR_25329375_ChIP-Seq_VCAP_Human1.02188194
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02124613
85NANOG_20526341_ChIP-Seq_ESCs_Human1.02078983
86PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01925233
87TP53_20018659_ChIP-ChIP_R1E_Mouse1.00552168
88CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00367497
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99843728
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98912788
91CTCF_27219007_Chip-Seq_Bcells_Human0.98690839
92RNF2_27304074_Chip-Seq_ESCs_Mouse0.97782493
93NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95294420
94GATA1_26923725_Chip-Seq_HPCs_Mouse0.94513956
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93526660
96ERG_20517297_ChIP-Seq_VCAP_Human0.91082023
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89978563
98RAC3_21632823_ChIP-Seq_H3396_Human0.87961718
99TCF4_22108803_ChIP-Seq_LS180_Human0.87874637
100TCF4_23295773_ChIP-Seq_U87_Human0.87511111

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization3.51986760
2MP0010386_abnormal_urinary_bladder3.29329608
3MP0003878_abnormal_ear_physiology3.24922452
4MP0005377_hearing/vestibular/ear_phenot3.24922452
5MP0002160_abnormal_reproductive_system3.12548591
6MP0002822_catalepsy3.04394671
7MP0005499_abnormal_olfactory_system2.69585910
8MP0005394_taste/olfaction_phenotype2.69585910
9MP0003315_abnormal_perineum_morphology2.65582697
10MP0001529_abnormal_vocalization2.55589950
11MP0001485_abnormal_pinna_reflex2.42170517
12MP0010368_abnormal_lymphatic_system2.40602012
13MP0008004_abnormal_stomach_pH2.19873876
14MP0002653_abnormal_ependyma_morphology2.05915440
15MP0003136_yellow_coat_color2.05760167
16MP0003880_abnormal_central_pattern1.99264841
17MP0006276_abnormal_autonomic_nervous1.97972412
18MP0005646_abnormal_pituitary_gland1.92986283
19MP0001905_abnormal_dopamine_level1.90324380
20MP0001188_hyperpigmentation1.90192874
21MP0008789_abnormal_olfactory_epithelium1.86563927
22MP0002638_abnormal_pupillary_reflex1.80009104
23MP0004272_abnormal_basement_membrane1.76620966
24MP0000778_abnormal_nervous_system1.70846720
25MP0001664_abnormal_digestion1.68128878
26MP0000538_abnormal_urinary_bladder1.67109694
27MP0009250_abnormal_appendicular_skeleto1.63879281
28MP0000013_abnormal_adipose_tissue1.62408196
29MP0005389_reproductive_system_phenotype1.57207428
30MP0002735_abnormal_chemical_nociception1.57153287
31MP0006072_abnormal_retinal_apoptosis1.56722758
32MP0003806_abnormal_nucleotide_metabolis1.56560082
33MP0001984_abnormal_olfaction1.52813724
34MP0009697_abnormal_copulation1.50099706
35MP0001486_abnormal_startle_reflex1.45954686
36MP0003890_abnormal_embryonic-extraembry1.45546340
37MP0000631_abnormal_neuroendocrine_gland1.45504375
38MP0001968_abnormal_touch/_nociception1.45208772
39MP0001919_abnormal_reproductive_system1.44243767
40MP0003698_abnormal_male_reproductive1.43680185
41MP0000049_abnormal_middle_ear1.40793578
42MP0004215_abnormal_myocardial_fiber1.39946047
43MP0004084_abnormal_cardiac_muscle1.36432367
44MP0010030_abnormal_orbit_morphology1.36274424
45MP0002295_abnormal_pulmonary_circulatio1.33283820
46MP0003635_abnormal_synaptic_transmissio1.29052277
47MP0002272_abnormal_nervous_system1.24573804
48MP0002233_abnormal_nose_morphology1.23080654
49MP0002127_abnormal_cardiovascular_syste1.22077738
50MP0001929_abnormal_gametogenesis1.21909429
51MP0005058_abnormal_lysosome_morphology1.18969659
52MP0004859_abnormal_synaptic_plasticity1.18848034
53MP0005503_abnormal_tendon_morphology1.18719988
54MP0002572_abnormal_emotion/affect_behav1.18076564
55MP0005409_darkened_coat_color1.17034283
56MP0005248_abnormal_Harderian_gland1.12881750
57MP0002752_abnormal_somatic_nervous1.12482937
58MP0002184_abnormal_innervation1.07726722
59MP0004145_abnormal_muscle_electrophysio1.03623240
60MP0002132_abnormal_respiratory_system1.03250798
61MP0000955_abnormal_spinal_cord1.03076414
62MP0000026_abnormal_inner_ear1.02903787
63MP0002249_abnormal_larynx_morphology1.01380760
64MP0002837_dystrophic_cardiac_calcinosis0.99860604
65MP0002067_abnormal_sensory_capabilities0.98736539
66MP0003385_abnormal_body_wall0.98269476
67MP0000749_muscle_degeneration0.98049614
68MP0004924_abnormal_behavior0.93550933
69MP0005386_behavior/neurological_phenoty0.93550933
70MP0010234_abnormal_vibrissa_follicle0.93372255
71MP0002557_abnormal_social/conspecific_i0.91698671
72MP0002210_abnormal_sex_determination0.91277909
73MP0005551_abnormal_eye_electrophysiolog0.90174164
74MP0002102_abnormal_ear_morphology0.89827673
75MP0003936_abnormal_reproductive_system0.87983743
76MP0002882_abnormal_neuron_morphology0.87598013
77MP0001727_abnormal_embryo_implantation0.87110661
78MP0002115_abnormal_skeleton_extremities0.86939442
79MP0001963_abnormal_hearing_physiology0.86497275
80MP0003632_abnormal_nervous_system0.85767644
81MP0000470_abnormal_stomach_morphology0.83089465
82MP0005647_abnormal_sex_gland0.81762151
83MP0001501_abnormal_sleep_pattern0.81719002
84MP0005253_abnormal_eye_physiology0.81478574
85MP0008775_abnormal_heart_ventricle0.80868288
86MP0001293_anophthalmia0.80844069
87MP0000427_abnormal_hair_cycle0.80383297
88MP0009046_muscle_twitch0.80006367
89MP0003631_nervous_system_phenotype0.79557237
90MP0000230_abnormal_systemic_arterial0.79222305
91MP0006292_abnormal_olfactory_placode0.78665866
92MP0001145_abnormal_male_reproductive0.78604358
93MP0009745_abnormal_behavioral_response0.78168482
94MP0003633_abnormal_nervous_system0.77603216
95MP0009780_abnormal_chondrocyte_physiolo0.77420281
96MP0004036_abnormal_muscle_relaxation0.76985795
97MP0005391_vision/eye_phenotype0.76091731
98MP0003283_abnormal_digestive_organ0.75981524
99MP0002282_abnormal_trachea_morphology0.75928455
100MP0002063_abnormal_learning/memory/cond0.75865883

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)4.63554880
2Absent/shortened dynein arms (HP:0200106)4.63554880
3Abnormal ciliary motility (HP:0012262)4.60773960
4Abnormal respiratory motile cilium physiology (HP:0012261)4.13181252
5Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)4.12301287
6Ventricular fibrillation (HP:0001663)4.09904148
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.96780941
8Abnormal respiratory epithelium morphology (HP:0012253)3.91603572
9Abnormal respiratory motile cilium morphology (HP:0005938)3.91603572
10Protruding tongue (HP:0010808)3.78001565
11Urinary urgency (HP:0000012)3.71399164
12Abnormality of the frontal sinuses (HP:0002687)3.33642981
13Sex reversal (HP:0012245)3.23696835
14Abnormal sex determination (HP:0012244)3.23696835
15Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.17532242
16Retinal dysplasia (HP:0007973)3.17469097
17Bronchomalacia (HP:0002780)3.13454097
18Cerebellar dysplasia (HP:0007033)3.10192430
19Deep palmar crease (HP:0006191)3.03539384
20Abnormality of the columella (HP:0009929)2.97778975
21Spinal rigidity (HP:0003306)2.90695962
22Type II lissencephaly (HP:0007260)2.87429352
23Concave nail (HP:0001598)2.79949858
24Sensory axonal neuropathy (HP:0003390)2.77996550
25Absent rod-and cone-mediated responses on ERG (HP:0007688)2.77529767
26Male pseudohermaphroditism (HP:0000037)2.74221996
27Pancreatic fibrosis (HP:0100732)2.72294734
28Rib fusion (HP:0000902)2.65968961
29Syncope (HP:0001279)2.65833939
30Hypothermia (HP:0002045)2.62849488
31Genu recurvatum (HP:0002816)2.55997409
32Reduced antithrombin III activity (HP:0001976)2.52141924
33Thoracic kyphosis (HP:0002942)2.50948930
34Nephronophthisis (HP:0000090)2.49058611
35Abdominal situs inversus (HP:0003363)2.47733958
36Abnormality of abdominal situs (HP:0011620)2.47733958
37Prolonged QT interval (HP:0001657)2.47042017
38Median cleft lip (HP:0000161)2.45486992
39Rhinitis (HP:0012384)2.44975491
40Delayed gross motor development (HP:0002194)2.38477398
41High pitched voice (HP:0001620)2.37149095
42Infertility (HP:0000789)2.36487152
43Self-mutilation (HP:0000742)2.35874409
44Resting tremor (HP:0002322)2.32157558
45Molar tooth sign on MRI (HP:0002419)2.31799687
46Abnormality of midbrain morphology (HP:0002418)2.31799687
47Curly hair (HP:0002212)2.31534839
48Congenital hepatic fibrosis (HP:0002612)2.29734777
49True hermaphroditism (HP:0010459)2.29078073
50Inability to walk (HP:0002540)2.25724298
51Renal dysplasia (HP:0000110)2.25682217
52Megalencephaly (HP:0001355)2.23431621
53Abnormality of the incisor (HP:0000676)2.23202769
54Abolished electroretinogram (ERG) (HP:0000550)2.23072567
55Pancreatic cysts (HP:0001737)2.22119001
56Tracheomalacia (HP:0002779)2.19779206
57Hypophosphatemic rickets (HP:0004912)2.17569923
58Broad-based gait (HP:0002136)2.17364180
59Buphthalmos (HP:0000557)2.17213964
60Clumsiness (HP:0002312)2.16527440
61Hypoplasia of the uterus (HP:0000013)2.12802385
62Abnormality of macular pigmentation (HP:0008002)2.12488403
63Abnormality of dental color (HP:0011073)2.10724823
64Aortic aneurysm (HP:0004942)2.10705318
65Absent speech (HP:0001344)2.09461885
66Vitreoretinal degeneration (HP:0000655)2.08109657
67Narrow forehead (HP:0000341)2.06211587
68Morphological abnormality of the pyramidal tract (HP:0002062)2.05811403
69Irregular vertebral endplates (HP:0003301)2.03172383
70Facial hemangioma (HP:0000329)2.01684624
71Abnormality of the renal medulla (HP:0100957)1.99124695
72Unsteady gait (HP:0002317)1.98200567
73High anterior hairline (HP:0009890)1.89413826
74Achilles tendon contracture (HP:0001771)1.89245845
75Gonadal dysgenesis (HP:0000133)1.88409160
76Drooling (HP:0002307)1.87651663
77Intestinal atresia (HP:0011100)1.85996524
78Polyphagia (HP:0002591)1.85964772
79Polydipsia (HP:0001959)1.85411080
80Abnormal drinking behavior (HP:0030082)1.85411080
81Atonic seizures (HP:0010819)1.84440895
82Bulbous nose (HP:0000414)1.84349704
83Postural instability (HP:0002172)1.83474266
84Cerebral hypomyelination (HP:0006808)1.83008594
85Anterior segment dysgenesis (HP:0007700)1.80371404
86Abnormality of the shoulder girdle musculature (HP:0001435)1.80092940
87Aplasia/hypoplasia of the uterus (HP:0008684)1.79879201
88Impaired vibration sensation in the lower limbs (HP:0002166)1.79445082
89Postaxial foot polydactyly (HP:0001830)1.78855988
90Sclerocornea (HP:0000647)1.78337866
91Abnormality of lateral ventricle (HP:0030047)1.78300949
92Abnormal rod and cone electroretinograms (HP:0008323)1.78004012
93Sudden death (HP:0001699)1.77177284
94Chronic hepatic failure (HP:0100626)1.76620603
95Abnormality of the vertebral endplates (HP:0005106)1.76054703
96Postaxial hand polydactyly (HP:0001162)1.74001064
97Coxa valga (HP:0002673)1.73541346
98Gastrointestinal atresia (HP:0002589)1.71808023
99Cystic liver disease (HP:0006706)1.71142391
100Short palpebral fissure (HP:0012745)1.68814160

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK18.75492647
2MARK34.12668375
3STK38L3.97338969
4LATS13.13190064
5MAP2K73.10751166
6CASK2.92191828
7NEK22.58652341
8MYLK2.47509419
9FRK2.40034505
10MAPK151.97755603
11ZAK1.93967204
12TLK11.84103593
13STK381.83064912
14TNIK1.80781406
15CSNK1G31.77792522
16CSNK1G21.70352095
17ADRBK21.68190726
18CSNK1A1L1.61128436
19OBSCN1.54586296
20IRAK21.48842393
21TAF11.33506372
22CSNK1G11.32559956
23DYRK31.26771671
24SGK4941.23700290
25SGK2231.23700290
26CDK31.18228358
27FGFR21.18020691
28BMPR1B1.16899035
29TIE11.15658533
30GRK11.12682399
31TGFBR10.93479305
32MAP3K90.89779760
33CCNB10.87601650
34FLT30.87217899
35RPS6KA50.86965045
36PKN20.83416597
37LATS20.82598420
38CAMKK20.82132068
39MARK10.81675955
40PRKCQ0.77742460
41SGK20.77659728
42NUAK10.73525809
43EIF2AK30.73027078
44BRSK20.72747724
45PRKG20.72188754
46DAPK30.70746989
47NTRK20.70526095
48DYRK20.69403125
49BRD40.66141136
50PAK20.64855354
51VRK10.63087319
52MAP3K40.63018672
53PNCK0.62893751
54PRKG10.58045539
55WNK30.57332842
56CDK140.56878997
57PTK2B0.56701071
58WNK10.52787625
59RPS6KB10.51861342
60STK30.51509937
61CDK90.50115685
62MOS0.47098856
63MAP3K10.46581028
64KIT0.43695475
65CAMK10.43074713
66DAPK20.42760164
67AKT30.42614948
68WEE10.41776489
69PLK10.40349583
70CDK50.40053684
71RPS6KA40.39456320
72CAMK1G0.38761974
73AURKA0.38067989
74CSNK1D0.36002678
75WNK40.35479924
76PKN10.34847343
77MARK20.34504101
78CSNK1A10.33911135
79GRK50.33518055
80STK110.33167409
81BLK0.32626264
82CLK10.32578048
83PRKAA10.32025672
84MAPK130.30719623
85DYRK1B0.30394155
86STK390.30180516
87ROCK10.30069613
88ADRBK10.29501389
89CAMKK10.28700513
90MAP3K50.28435087
91RPS6KA60.28322204
92PHKG10.26272966
93PHKG20.26272966
94PRKD20.25373922
95RPS6KA20.25227719
96PRKCE0.25145830
97PIK3CA0.24569672
98AKT20.24511306
99SGK30.24134266
100ATM0.23361618

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.34812265
2Gap junction_Homo sapiens_hsa045403.27862257
3Olfactory transduction_Homo sapiens_hsa047402.75032293
4Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.74121044
5Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.64450742
6Hedgehog signaling pathway_Homo sapiens_hsa043402.59705063
7Butanoate metabolism_Homo sapiens_hsa006502.47805177
8Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.41881864
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.35327563
10Phototransduction_Homo sapiens_hsa047441.91438944
11Circadian entrainment_Homo sapiens_hsa047131.67933303
12Nitrogen metabolism_Homo sapiens_hsa009101.61801935
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.57344195
14Alcoholism_Homo sapiens_hsa050341.47819023
15Oxytocin signaling pathway_Homo sapiens_hsa049211.45676881
16Taste transduction_Homo sapiens_hsa047421.44068663
17Vascular smooth muscle contraction_Homo sapiens_hsa042701.43354197
18Nicotine addiction_Homo sapiens_hsa050331.40745124
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.38608620
20Renin secretion_Homo sapiens_hsa049241.34378850
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30800486
22cGMP-PKG signaling pathway_Homo sapiens_hsa040221.30770649
23Basal transcription factors_Homo sapiens_hsa030221.29515769
24Salivary secretion_Homo sapiens_hsa049701.27584603
25Propanoate metabolism_Homo sapiens_hsa006401.20674507
26Axon guidance_Homo sapiens_hsa043601.18837614
27Cholinergic synapse_Homo sapiens_hsa047251.18586159
28Cocaine addiction_Homo sapiens_hsa050301.14817269
29Endometrial cancer_Homo sapiens_hsa052131.11498431
30GABAergic synapse_Homo sapiens_hsa047271.11091029
31Basal cell carcinoma_Homo sapiens_hsa052171.08042976
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07980926
33Morphine addiction_Homo sapiens_hsa050321.06866332
34N-Glycan biosynthesis_Homo sapiens_hsa005101.06068131
35Dopaminergic synapse_Homo sapiens_hsa047281.05945342
36Insulin secretion_Homo sapiens_hsa049111.04804477
37Chemical carcinogenesis_Homo sapiens_hsa052041.04776740
38Dorso-ventral axis formation_Homo sapiens_hsa043201.04440075
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.03424023
40Circadian rhythm_Homo sapiens_hsa047101.01752301
41Melanogenesis_Homo sapiens_hsa049160.97597125
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96863789
43Melanoma_Homo sapiens_hsa052180.96538707
44Wnt signaling pathway_Homo sapiens_hsa043100.92677772
45Maturity onset diabetes of the young_Homo sapiens_hsa049500.92638891
46Tryptophan metabolism_Homo sapiens_hsa003800.92501106
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91576313
48Glutamatergic synapse_Homo sapiens_hsa047240.90178404
49Serotonergic synapse_Homo sapiens_hsa047260.89889905
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89819124
51Regulation of autophagy_Homo sapiens_hsa041400.84882909
52Phagosome_Homo sapiens_hsa041450.83516820
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81390290
54Fanconi anemia pathway_Homo sapiens_hsa034600.81159080
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81119329
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80895209
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80652487
58Dilated cardiomyopathy_Homo sapiens_hsa054140.80471895
59Gastric acid secretion_Homo sapiens_hsa049710.78951663
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75893270
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75166399
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74076093
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73227248
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73171326
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70377592
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69731600
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69532904
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66417949
69Hippo signaling pathway_Homo sapiens_hsa043900.66015423
70ECM-receptor interaction_Homo sapiens_hsa045120.65914735
71Vitamin B6 metabolism_Homo sapiens_hsa007500.65480410
72Apoptosis_Homo sapiens_hsa042100.64715532
73Peroxisome_Homo sapiens_hsa041460.64682151
74Calcium signaling pathway_Homo sapiens_hsa040200.64221707
75Estrogen signaling pathway_Homo sapiens_hsa049150.63370983
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.62719112
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60994643
78beta-Alanine metabolism_Homo sapiens_hsa004100.59301233
79Glucagon signaling pathway_Homo sapiens_hsa049220.58404519
80cAMP signaling pathway_Homo sapiens_hsa040240.58266027
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57417710
82MAPK signaling pathway_Homo sapiens_hsa040100.56945571
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56770234
84Amphetamine addiction_Homo sapiens_hsa050310.55876500
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55282332
86Systemic lupus erythematosus_Homo sapiens_hsa053220.54874281
87Pyruvate metabolism_Homo sapiens_hsa006200.53871265
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52440239
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51355001
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50654147
91Oocyte meiosis_Homo sapiens_hsa041140.49044798
92Focal adhesion_Homo sapiens_hsa045100.48401131
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.45659234
94PPAR signaling pathway_Homo sapiens_hsa033200.45428294
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44652617
96Arginine biosynthesis_Homo sapiens_hsa002200.42724951
97Prostate cancer_Homo sapiens_hsa052150.42647299
98Long-term depression_Homo sapiens_hsa047300.42399617
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42326742
100Purine metabolism_Homo sapiens_hsa002300.38131686

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