ATE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)5.72286421
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.40345259
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.95825901
4synaptic vesicle exocytosis (GO:0016079)4.90731012
5regulation of response to tumor cell (GO:0002834)4.62472010
6positive regulation of response to tumor cell (GO:0002836)4.62472010
7positive regulation of immune response to tumor cell (GO:0002839)4.62472010
8regulation of immune response to tumor cell (GO:0002837)4.62472010
9regulation of meiosis I (GO:0060631)4.51318283
10response to pheromone (GO:0019236)4.40556059
11synaptic vesicle maturation (GO:0016188)4.37090279
12cellular potassium ion homeostasis (GO:0030007)4.32789680
13neuron cell-cell adhesion (GO:0007158)4.30947046
14locomotory exploration behavior (GO:0035641)4.26479616
15regulation of synaptic vesicle exocytosis (GO:2000300)4.25941330
16glutamate secretion (GO:0014047)4.05632961
17protein localization to synapse (GO:0035418)3.95952202
18regulation of DNA endoreduplication (GO:0032875)3.94761794
19regulation of synaptic vesicle transport (GO:1902803)3.88733923
20vocalization behavior (GO:0071625)3.85810174
21resolution of meiotic recombination intermediates (GO:0000712)3.82988014
22neurotransmitter secretion (GO:0007269)3.81443243
23DNA double-strand break processing (GO:0000729)3.79860344
24gonadal mesoderm development (GO:0007506)3.78634257
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.76609836
26mating behavior (GO:0007617)3.73844687
27protein K11-linked deubiquitination (GO:0035871)3.69982839
28monoubiquitinated protein deubiquitination (GO:0035520)3.67178544
29neurotransmitter-gated ion channel clustering (GO:0072578)3.65416725
30positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.64237393
31detection of calcium ion (GO:0005513)3.58456259
32interkinetic nuclear migration (GO:0022027)3.57183703
33exploration behavior (GO:0035640)3.55257626
34synaptic vesicle endocytosis (GO:0048488)3.52431511
35layer formation in cerebral cortex (GO:0021819)3.46367812
36cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.42976593
37glutamate receptor signaling pathway (GO:0007215)3.42916839
38regulation of glutamate receptor signaling pathway (GO:1900449)3.42653703
39proline transport (GO:0015824)3.42053817
40regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.38971438
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.37975159
42cerebellar Purkinje cell differentiation (GO:0021702)3.37740235
43ionotropic glutamate receptor signaling pathway (GO:0035235)3.36690023
44positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.36564165
45synaptic vesicle docking involved in exocytosis (GO:0016081)3.35442036
46acrosome assembly (GO:0001675)3.33650766
47gamma-aminobutyric acid signaling pathway (GO:0007214)3.33207293
48neurotransmitter transport (GO:0006836)3.33122329
49cell communication by electrical coupling (GO:0010644)3.28901865
50G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.25732430
51regulation of Golgi to plasma membrane protein transport (GO:0042996)3.22477691
52neuron-neuron synaptic transmission (GO:0007270)3.21773519
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.21172218
54neuron recognition (GO:0008038)3.19346638
55regulation of vesicle fusion (GO:0031338)3.18570055
56sister chromatid cohesion (GO:0007062)3.16555920
57activation of protein kinase A activity (GO:0034199)3.15115957
58long-term synaptic potentiation (GO:0060291)3.13796847
59positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.13057668
60innervation (GO:0060384)3.11954846
61neural tube formation (GO:0001841)3.11912188
62nuclear pore organization (GO:0006999)3.11048837
63regulation of synapse structural plasticity (GO:0051823)3.09256583
64synaptic transmission, glutamatergic (GO:0035249)3.09203822
65sodium ion export (GO:0071436)3.08787898
66protein neddylation (GO:0045116)3.07897000
67phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.07663123
68striatum development (GO:0021756)3.06831138
69transmission of nerve impulse (GO:0019226)3.05410390
70gamma-aminobutyric acid transport (GO:0015812)3.05369061
71protein K63-linked deubiquitination (GO:0070536)3.03853941
72retinal rod cell development (GO:0046548)3.03853158
73regulation of synaptic transmission, glutamatergic (GO:0051966)3.03783462
74long-term memory (GO:0007616)3.01566687
75regulation of neuronal synaptic plasticity (GO:0048168)3.01217638
76axonal fasciculation (GO:0007413)3.00315801
77regulation of neurotransmitter levels (GO:0001505)2.97624817
78response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.97607133
79positive regulation of membrane potential (GO:0045838)2.95573360
80activated T cell proliferation (GO:0050798)2.94822645
81L-alpha-amino acid transmembrane transport (GO:1902475)2.94644709
82response to histamine (GO:0034776)2.94381061
83positive regulation of potassium ion transmembrane transport (GO:1901381)2.93934491
84dendrite morphogenesis (GO:0048813)2.93608116
85membrane depolarization during action potential (GO:0086010)2.93165208
86peroxisome fission (GO:0016559)2.92929246
87regulation of calcium ion-dependent exocytosis (GO:0017158)2.92473378
88neuronal action potential propagation (GO:0019227)2.92021910
89vesicle transport along microtubule (GO:0047496)2.91766197
90regulation of beta-amyloid formation (GO:1902003)2.91245877
91potassium ion homeostasis (GO:0055075)2.90821628
92piRNA metabolic process (GO:0034587)2.90249579
93positive regulation of synaptic transmission, GABAergic (GO:0032230)2.89018187
94positive regulation of synapse maturation (GO:0090129)2.88170511
95establishment of synaptic vesicle localization (GO:0097480)2.87880565
96synaptic vesicle transport (GO:0048489)2.87880565
97protein targeting to Golgi (GO:0000042)2.86645557
98negative regulation of synaptic transmission, GABAergic (GO:0032229)2.84296072
99regulation of sarcomere organization (GO:0060297)2.83817275
100regulation of acyl-CoA biosynthetic process (GO:0050812)2.81966441
101potassium ion import (GO:0010107)2.81446833
102regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.81300559
103positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.79894199
104double-strand break repair via nonhomologous end joining (GO:0006303)2.79588606
105non-recombinational repair (GO:0000726)2.79588606
106replication fork processing (GO:0031297)2.78680114
107positive regulation of potassium ion transport (GO:0043268)2.77767999
108synapse assembly (GO:0007416)2.77459878
109negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.76950443
110regulation of long-term neuronal synaptic plasticity (GO:0048169)2.76814816
111nucleus localization (GO:0051647)2.75825719
112negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.75681271
113regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.75002147
114regulation of neurotransmitter secretion (GO:0046928)2.74142645
115neuromuscular process controlling posture (GO:0050884)2.74094421
116regulation of postsynaptic membrane potential (GO:0060078)2.74035289
117suckling behavior (GO:0001967)2.71897537
118regulation of excitatory postsynaptic membrane potential (GO:0060079)2.71666612
119myelin assembly (GO:0032288)2.71187553
120regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.70939873
121positive regulation of mitochondrial fission (GO:0090141)2.69283127
122insulin secretion (GO:0030073)2.68051949
123synapse organization (GO:0050808)2.66345844
124microtubule anchoring (GO:0034453)2.66273851
125regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.65737926
126establishment of vesicle localization (GO:0051650)2.64366777
127negative regulation of cytosolic calcium ion concentration (GO:0051481)2.63875103
128response to auditory stimulus (GO:0010996)2.63492399
129synapsis (GO:0007129)2.62953167
130regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.62060191
131righting reflex (GO:0060013)2.62017325
132regulation of amyloid precursor protein catabolic process (GO:1902991)2.61704860
133synaptic transmission (GO:0007268)2.61659082
134cerebellar granule cell differentiation (GO:0021707)2.61035614
135prepulse inhibition (GO:0060134)2.60750909
136organelle transport along microtubule (GO:0072384)2.59360937
137negative regulation of fibroblast apoptotic process (GO:2000270)2.58579615
138regulation of neurotransmitter transport (GO:0051588)2.58171802
139regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.58016973
140fibroblast migration (GO:0010761)2.57910762
141regulation of synaptic plasticity (GO:0048167)2.57759825
142cell differentiation in hindbrain (GO:0021533)2.56692106
143membrane repolarization (GO:0086009)2.55228954
144establishment of protein localization to Golgi (GO:0072600)2.54601624
145regulation of coenzyme metabolic process (GO:0051196)2.54241834
146regulation of cofactor metabolic process (GO:0051193)2.54241834
147positive regulation of meiosis (GO:0045836)2.53891355
148negative regulation of DNA-dependent DNA replication (GO:2000104)2.51052942
149histone mRNA catabolic process (GO:0071044)2.50987588
150phospholipid homeostasis (GO:0055091)2.50778358
151microtubule polymerization or depolymerization (GO:0031109)2.49490865
152positive regulation of meiotic cell cycle (GO:0051446)2.48935561
153regulation of protein glycosylation (GO:0060049)2.47551972
154regulation of establishment of cell polarity (GO:2000114)2.46078150
155regulation of clathrin-mediated endocytosis (GO:2000369)2.44699567
156nuclear pore complex assembly (GO:0051292)2.44211026
157vascular smooth muscle contraction (GO:0014829)2.43933676
158single strand break repair (GO:0000012)2.41457675
159protein K48-linked deubiquitination (GO:0071108)2.38387452
160ether lipid metabolic process (GO:0046485)2.34988018
161microtubule depolymerization (GO:0007019)2.34293776
162positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.33907953
163somatic diversification of immune receptors via somatic mutation (GO:0002566)2.32286145
164somatic hypermutation of immunoglobulin genes (GO:0016446)2.32286145
165phospholipid translocation (GO:0045332)2.29977529
166lipid translocation (GO:0034204)2.29977529
167negative regulation of oligodendrocyte differentiation (GO:0048715)2.27457948
168negative regulation of calcium ion transport into cytosol (GO:0010523)2.24909848
169sarcomere organization (GO:0045214)2.24408635
170relaxation of cardiac muscle (GO:0055119)2.23215989
171sex differentiation (GO:0007548)2.23117875
172detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.22720822
173paraxial mesoderm development (GO:0048339)2.22493184
174carnitine shuttle (GO:0006853)2.21934805
175regulation of cell communication by electrical coupling (GO:0010649)2.20989310
176regulation of centriole replication (GO:0046599)2.20251643
177regulation of centrosome duplication (GO:0010824)2.20142379
178positive regulation of muscle hypertrophy (GO:0014742)2.19688818
179positive regulation of cardiac muscle hypertrophy (GO:0010613)2.19688818
180negative regulation of potassium ion transmembrane transport (GO:1901380)2.19635471
181genitalia morphogenesis (GO:0035112)2.18580804
182negative regulation of neurological system process (GO:0031645)2.18355457
183gastrulation with mouth forming second (GO:0001702)2.17287826
184meiotic chromosome segregation (GO:0045132)2.16985038
185peptidyl-lysine dimethylation (GO:0018027)2.16585701
186N-terminal protein amino acid acetylation (GO:0006474)2.15875217
187serotonin receptor signaling pathway (GO:0007210)2.15663862
188protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.15496961
189male meiosis (GO:0007140)2.15017134
190regulation of glucokinase activity (GO:0033131)2.14948310
191regulation of hexokinase activity (GO:1903299)2.14948310
192inner ear receptor stereocilium organization (GO:0060122)2.13846074
193regulation of pigment cell differentiation (GO:0050932)2.11796881
194positive regulation of T cell cytokine production (GO:0002726)2.11703873

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.38101212
2GBX2_23144817_ChIP-Seq_PC3_Human3.80811083
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.04172854
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.66052192
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.61603712
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.56440712
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.49451873
8REST_21632747_ChIP-Seq_MESCs_Mouse2.42783902
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.36877020
10TAF15_26573619_Chip-Seq_HEK293_Human2.24085002
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20321486
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.15572036
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10656973
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.10250521
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07624395
16DROSHA_22980978_ChIP-Seq_HELA_Human2.07386609
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07148853
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.06483353
19AR_21572438_ChIP-Seq_LNCaP_Human2.01487149
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00333337
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99987146
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99322449
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99122119
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99122119
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98672962
26* SMAD4_21799915_ChIP-Seq_A2780_Human1.95213694
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94278249
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.93340163
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.92645145
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92497004
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90978696
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.90736896
33EWS_26573619_Chip-Seq_HEK293_Human1.87384754
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.86952985
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85763667
36P300_19829295_ChIP-Seq_ESCs_Human1.84946905
37ZNF274_21170338_ChIP-Seq_K562_Hela1.84260143
38* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84200084
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.78450631
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78216705
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.76444895
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.76243891
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70670123
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69758420
45IGF1R_20145208_ChIP-Seq_DFB_Human1.69722729
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.66735760
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.66164399
48* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64409361
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62941403
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61914392
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.61740977
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60634800
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58672070
54AR_25329375_ChIP-Seq_VCAP_Human1.58149310
55* STAT3_23295773_ChIP-Seq_U87_Human1.57845775
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56448985
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.56140902
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.54663633
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.53393769
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52893927
61* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51204987
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.49249879
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49003944
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48440844
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.44991438
66E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44480389
67CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.43400566
68FUS_26573619_Chip-Seq_HEK293_Human1.42538744
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42036238
70RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.37182634
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35790078
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.35120453
73FOXM1_26456572_ChIP-Seq_MCF-7_Human1.33474711
74BCAT_22108803_ChIP-Seq_LS180_Human1.32609774
75VDR_22108803_ChIP-Seq_LS180_Human1.32232729
76TCF4_23295773_ChIP-Seq_U87_Human1.30789343
77HTT_18923047_ChIP-ChIP_STHdh_Human1.30586268
78TCF4_22108803_ChIP-Seq_LS180_Human1.30405890
79* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30362418
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.30292364
81ER_23166858_ChIP-Seq_MCF-7_Human1.28315477
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28235530
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27959207
84SMAD_19615063_ChIP-ChIP_OVARY_Human1.27501772
85* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27176429
86PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25828897
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.25776008
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25250273
89P53_22387025_ChIP-Seq_ESCs_Mouse1.24524420
90AR_19668381_ChIP-Seq_PC3_Human1.23361623
91OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22742574
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20191436
93RUNX2_22187159_ChIP-Seq_PCA_Human1.19586858
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19283387
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17802639
96CBX2_27304074_Chip-Seq_ESCs_Mouse1.17221321
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15825670
98SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15544834
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.15087657
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14952098
101CMYC_18555785_Chip-Seq_ESCs_Mouse1.14268261
102TAL1_26923725_Chip-Seq_HPCs_Mouse1.13906123
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13900245
104* CDX2_22108803_ChIP-Seq_LS180_Human1.13685612
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13230889
106YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12967162
107TCF4_18268006_ChIP-ChIP_LS174T_Human1.12606946
108* ELK1_19687146_ChIP-ChIP_HELA_Human1.12076443
109IRF1_19129219_ChIP-ChIP_H3396_Human1.11797378
110TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11628429
111RNF2_27304074_Chip-Seq_NSC_Mouse1.11025735
112NANOG_18555785_Chip-Seq_ESCs_Mouse1.10760986
113P300_18555785_Chip-Seq_ESCs_Mouse1.10637779
114CBP_20019798_ChIP-Seq_JUKART_Human1.10048198
115IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10048198
116CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10022598
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09042506
118FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.08466611
119P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07487066
120EP300_21415370_ChIP-Seq_HL-1_Mouse1.05935181
121OCT4_18555785_Chip-Seq_ESCs_Mouse1.05340186
122STAT3_18555785_Chip-Seq_ESCs_Mouse1.05291170
123IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05223452
124SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04942200
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04642967
126SOX2_18555785_Chip-Seq_ESCs_Mouse1.04538411
127PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04194093
128FLI1_21867929_ChIP-Seq_TH2_Mouse1.04043278
129SMAD3_21741376_ChIP-Seq_ESCs_Human1.03698380
130NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03242221
131NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03242221
132EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02740065
133TP53_16413492_ChIP-PET_HCT116_Human1.01638318
134NMYC_18555785_Chip-Seq_ESCs_Mouse1.01347903
135JUN_21703547_ChIP-Seq_K562_Human1.00917811
136MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99532922
137BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98992229
138ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97660903
139PRDM14_20953172_ChIP-Seq_ESCs_Human0.97410031
140WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97167006
141LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97088502
142SMAD4_21741376_ChIP-Seq_HESCs_Human0.96962491
143AHR_22903824_ChIP-Seq_MCF-7_Human0.96862096
144CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96461475
145TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95931857

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.61979893
2MP0004859_abnormal_synaptic_plasticity4.31556874
3MP0003880_abnormal_central_pattern3.88039095
4MP0003635_abnormal_synaptic_transmissio3.33802288
5MP0000013_abnormal_adipose_tissue2.82677960
6MP0004270_analgesia2.63524922
7MP0009745_abnormal_behavioral_response2.61423315
8MP0009046_muscle_twitch2.58294850
9MP0002063_abnormal_learning/memory/cond2.57926557
10MP0003890_abnormal_embryonic-extraembry2.56479582
11* MP0002064_seizures2.52643164
12MP0009780_abnormal_chondrocyte_physiolo2.41593807
13MP0002572_abnormal_emotion/affect_behav2.39633875
14MP0002837_dystrophic_cardiac_calcinosis2.30584619
15MP0005423_abnormal_somatic_nervous2.28747131
16MP0006276_abnormal_autonomic_nervous2.27880583
17MP0005645_abnormal_hypothalamus_physiol2.26822773
18MP0002909_abnormal_adrenal_gland2.26249913
19MP0002272_abnormal_nervous_system2.25571293
20MP0010386_abnormal_urinary_bladder2.24813746
21MP0002734_abnormal_mechanical_nocicepti2.24330974
22MP0006072_abnormal_retinal_apoptosis2.20024818
23MP0005551_abnormal_eye_electrophysiolog2.19587169
24MP0001501_abnormal_sleep_pattern2.17135114
25MP0003646_muscle_fatigue2.14085594
26MP0001968_abnormal_touch/_nociception2.07747136
27MP0000383_abnormal_hair_follicle2.03636745
28MP0003122_maternal_imprinting2.03407375
29* MP0001486_abnormal_startle_reflex2.00752472
30MP0002163_abnormal_gland_morphology1.93949520
31MP0005646_abnormal_pituitary_gland1.90227646
32MP0002067_abnormal_sensory_capabilities1.90139494
33MP0002102_abnormal_ear_morphology1.87945121
34MP0010094_abnormal_chromosome_stability1.86979632
35* MP0001440_abnormal_grooming_behavior1.85612088
36MP0001529_abnormal_vocalization1.85609898
37MP0008058_abnormal_DNA_repair1.82687943
38MP0002733_abnormal_thermal_nociception1.82253600
39MP0001502_abnormal_circadian_rhythm1.82179470
40MP0005386_behavior/neurological_phenoty1.80553486
41MP0004924_abnormal_behavior1.80553486
42MP0004145_abnormal_muscle_electrophysio1.74855182
43MP0001984_abnormal_olfaction1.73717957
44MP0002735_abnormal_chemical_nociception1.73162470
45MP0010678_abnormal_skin_adnexa1.71082815
46MP0003221_abnormal_cardiomyocyte_apopto1.69159437
47MP0002557_abnormal_social/conspecific_i1.65570069
48MP0003567_abnormal_fetal_cardiomyocyte1.64059904
49MP0001970_abnormal_pain_threshold1.62021193
50MP0002184_abnormal_innervation1.57282211
51MP0008569_lethality_at_weaning1.56353682
52MP0003172_abnormal_lysosome_physiology1.56231001
53MP0002822_catalepsy1.55438585
54MP0000569_abnormal_digit_pigmentation1.55089453
55MP0008877_abnormal_DNA_methylation1.51648613
56MP0002736_abnormal_nociception_after1.50085166
57MP0005253_abnormal_eye_physiology1.46837047
58MP0000778_abnormal_nervous_system1.45804441
59MP0002638_abnormal_pupillary_reflex1.41888286
60MP0000427_abnormal_hair_cycle1.40155519
61MP0001299_abnormal_eye_distance/1.34186351
62MP0005464_abnormal_platelet_physiology1.32801176
63MP0004142_abnormal_muscle_tone1.32341389
64MP0003868_abnormal_feces_composition1.32307016
65MP0004233_abnormal_muscle_weight1.29809458
66MP0004811_abnormal_neuron_physiology1.29743606
67MP0004036_abnormal_muscle_relaxation1.29236210
68MP0002882_abnormal_neuron_morphology1.29092825
69MP0004484_altered_response_of1.27228053
70MP0002229_neurodegeneration1.26736601
71MP0003329_amyloid_beta_deposits1.25204884
72MP0000955_abnormal_spinal_cord1.24925008
73MP0001905_abnormal_dopamine_level1.24635011
74* MP0004215_abnormal_myocardial_fiber1.22959060
75MP0003633_abnormal_nervous_system1.22601531
76MP0003879_abnormal_hair_cell1.22165959
77* MP0002066_abnormal_motor_capabilities/c1.22060371
78MP0004043_abnormal_pH_regulation1.21336713
79MP0004147_increased_porphyrin_level1.20685433
80MP0004085_abnormal_heartbeat1.18546690
81MP0000751_myopathy1.17476704
82MP0002090_abnormal_vision1.17385923
83MP0002160_abnormal_reproductive_system1.16282015
84MP0004084_abnormal_cardiac_muscle1.15043949
85* MP0002972_abnormal_cardiac_muscle1.12921159
86MP0004957_abnormal_blastocyst_morpholog1.11465576
87MP0001188_hyperpigmentation1.10404318
88MP0010352_gastrointestinal_tract_polyps1.09089217
89* MP0005535_abnormal_body_temperature1.08974361
90MP0009697_abnormal_copulation1.06971310
91MP0002876_abnormal_thyroid_physiology1.04425922
92MP0003077_abnormal_cell_cycle1.03926093
93MP0004858_abnormal_nervous_system1.02099199
94MP0002269_muscular_atrophy1.00980803
95MP0002106_abnormal_muscle_physiology1.00514132
96MP0002233_abnormal_nose_morphology0.99923378
97MP0003787_abnormal_imprinting0.99361072
98MP0003137_abnormal_impulse_conducting0.98824751
99MP0003941_abnormal_skin_development0.98179484
100MP0004742_abnormal_vestibular_system0.98168798
101MP0000003_abnormal_adipose_tissue0.98020050
102MP0006035_abnormal_mitochondrial_morpho0.97529767
103MP0001544_abnormal_cardiovascular_syste0.97133351
104MP0005385_cardiovascular_system_phenoty0.97133351
105MP0000631_abnormal_neuroendocrine_gland0.97082360
106MP0008872_abnormal_physiological_respon0.96718935
107MP0005379_endocrine/exocrine_gland_phen0.95806404
108MP0003631_nervous_system_phenotype0.94953423
109MP0005248_abnormal_Harderian_gland0.94511573
110MP0003634_abnormal_glial_cell0.94363613
111MP0005085_abnormal_gallbladder_physiolo0.93259996
112MP0003950_abnormal_plasma_membrane0.90543733
113MP0003252_abnormal_bile_duct0.90346591
114MP0003690_abnormal_glial_cell0.89844571
115MP0004885_abnormal_endolymph0.89674918
116MP0002210_abnormal_sex_determination0.88193809
117MP0003937_abnormal_limbs/digits/tail_de0.88184910
118* MP0003183_abnormal_peptide_metabolism0.87971170
119MP0000647_abnormal_sebaceous_gland0.87446098
120* MP0002152_abnormal_brain_morphology0.87007614
121MP0006138_congestive_heart_failure0.85630617
122* MP0002069_abnormal_eating/drinking_beha0.85355255
123MP0003718_maternal_effect0.84763710
124MP0005167_abnormal_blood-brain_barrier0.83125023
125MP0000747_muscle_weakness0.82526579
126* MP0003698_abnormal_male_reproductive0.82333988
127MP0005187_abnormal_penis_morphology0.81765040
128* MP0001929_abnormal_gametogenesis0.81764403
129MP0004197_abnormal_fetal_growth/weight/0.80930351
130MP0002752_abnormal_somatic_nervous0.79923686
131MP0002234_abnormal_pharynx_morphology0.79710498
132MP0003693_abnormal_embryo_hatching0.79587677
133MP0003283_abnormal_digestive_organ0.79252689
134MP0004134_abnormal_chest_morphology0.78748361
135MP0004130_abnormal_muscle_cell0.78726486
136MP0009703_decreased_birth_body0.78175512
137* MP0000653_abnormal_sex_gland0.78154394
138* MP0001145_abnormal_male_reproductive0.77123876
139* MP0005620_abnormal_muscle_contractility0.74594452
140MP0002009_preneoplasia0.74073610
141* MP0001730_embryonic_growth_arrest0.74035109
142MP0005195_abnormal_posterior_eye0.73061503
143MP0005174_abnormal_tail_pigmentation0.72636067
144MP0000639_abnormal_adrenal_gland0.72020938
145MP0001963_abnormal_hearing_physiology0.71318582
146MP0003045_fibrosis0.71030150
147* MP0002078_abnormal_glucose_homeostasis0.70787678
148MP0002127_abnormal_cardiovascular_syste0.69895962
149MP0000465_gastrointestinal_hemorrhage0.69825782
150* MP0004087_abnormal_muscle_fiber0.69454629
151MP0000015_abnormal_ear_pigmentation0.69141935
152MP0010329_abnormal_lipoprotein_level0.69036981
153MP0001944_abnormal_pancreas_morphology0.67988095
154MP0003632_abnormal_nervous_system0.66784396
155MP0003121_genomic_imprinting0.65072185
156MP0000230_abnormal_systemic_arterial0.65038415
157MP0002693_abnormal_pancreas_physiology0.65036524
158MP0008775_abnormal_heart_ventricle0.64999896

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)5.76830440
2Focal motor seizures (HP:0011153)5.08604557
3Papillary thyroid carcinoma (HP:0002895)4.54903351
4Visual hallucinations (HP:0002367)4.39671458
5Oligodactyly (hands) (HP:0001180)4.22724577
6Atonic seizures (HP:0010819)4.21500795
7Epileptic encephalopathy (HP:0200134)4.05117288
8Progressive cerebellar ataxia (HP:0002073)4.03422141
9Focal seizures (HP:0007359)3.93214440
10Absence seizures (HP:0002121)3.77381642
11Febrile seizures (HP:0002373)3.67400505
12Central scotoma (HP:0000603)3.53018103
13Dialeptic seizures (HP:0011146)3.26933320
14Myokymia (HP:0002411)3.18071743
15Pheochromocytoma (HP:0002666)3.16513929
16Action tremor (HP:0002345)3.13756284
17Thyroid carcinoma (HP:0002890)3.12531782
18Generalized tonic-clonic seizures (HP:0002069)3.01500794
19Diastasis recti (HP:0001540)3.00740980
20Truncal ataxia (HP:0002078)2.93611422
21Depression (HP:0000716)2.92327153
22Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.90896943
23Ankle clonus (HP:0011448)2.90006974
24Stenosis of the external auditory canal (HP:0000402)2.87671803
25Supranuclear gaze palsy (HP:0000605)2.83585087
26Labial hypoplasia (HP:0000066)2.83495405
27Oligodactyly (HP:0012165)2.82804204
28Biliary tract neoplasm (HP:0100574)2.82767021
29Congenital stationary night blindness (HP:0007642)2.81923136
30Abnormality of the renal cortex (HP:0011035)2.80647556
31Hypoplastic labia majora (HP:0000059)2.80557830
32Gait imbalance (HP:0002141)2.79679354
33Menstrual irregularities (HP:0000858)2.79553585
34Papilledema (HP:0001085)2.76253917
35EEG with generalized epileptiform discharges (HP:0011198)2.73706398
36Epileptiform EEG discharges (HP:0011182)2.72808709
37Hepatoblastoma (HP:0002884)2.70955373
38Postural instability (HP:0002172)2.69597304
39Neuroendocrine neoplasm (HP:0100634)2.68049928
40Dysdiadochokinesis (HP:0002075)2.67734050
41Limb dystonia (HP:0002451)2.67020939
42Acanthocytosis (HP:0001927)2.65643345
43Hypoplastic female external genitalia (HP:0012815)2.62406342
44Anxiety (HP:0000739)2.58802905
45Agitation (HP:0000713)2.52372782
46Abnormality of the labia majora (HP:0012881)2.51267154
47Hypothermia (HP:0002045)2.47956157
48Congenital primary aphakia (HP:0007707)2.47899248
49Medial flaring of the eyebrow (HP:0010747)2.46880002
50Hemiparesis (HP:0001269)2.44897536
51Bundle branch block (HP:0011710)2.43933531
52Hypsarrhythmia (HP:0002521)2.43901108
53Excessive salivation (HP:0003781)2.42799038
54Drooling (HP:0002307)2.42799038
55Increased mean platelet volume (HP:0011877)2.42368291
56Abnormality of the left ventricular outflow tract (HP:0011103)2.42186366
57Subaortic stenosis (HP:0001682)2.42186366
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.39544574
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.39544574
60Retinal atrophy (HP:0001105)2.39389296
61Supernumerary spleens (HP:0009799)2.38205374
62Urinary bladder sphincter dysfunction (HP:0002839)2.38133443
63Renal cortical cysts (HP:0000803)2.36924377
64Dyschromatopsia (HP:0007641)2.36418474
65Neurofibrillary tangles (HP:0002185)2.32770724
66Hyperventilation (HP:0002883)2.31611921
67Gaze-evoked nystagmus (HP:0000640)2.29492802
68Bradykinesia (HP:0002067)2.29355238
69Hyperinsulinemic hypoglycemia (HP:0000825)2.29022882
70Rimmed vacuoles (HP:0003805)2.28055426
71Ectopic kidney (HP:0000086)2.27595273
72Scotoma (HP:0000575)2.27561497
73Diplopia (HP:0000651)2.26605168
74Abnormality of binocular vision (HP:0011514)2.26605168
75Abnormality of macular pigmentation (HP:0008002)2.26507555
76Dysmetria (HP:0001310)2.26469703
77Abnormal hair whorl (HP:0010721)2.25415242
78Genetic anticipation (HP:0003743)2.23649999
79Cerebral inclusion bodies (HP:0100314)2.23623896
80Overlapping toe (HP:0001845)2.23530969
81Broad-based gait (HP:0002136)2.22181182
82Rhabdomyosarcoma (HP:0002859)2.20914235
83Blue irides (HP:0000635)2.19440797
84Scanning speech (HP:0002168)2.18740047
85Abnormality of calcium-phosphate metabolism (HP:0100530)2.18071704
86Nephrogenic diabetes insipidus (HP:0009806)2.17889830
87Exercise-induced myalgia (HP:0003738)2.16334456
88Macroorchidism (HP:0000053)2.15423708
89Failure to thrive in infancy (HP:0001531)2.14635327
90Abnormal eating behavior (HP:0100738)2.14372218
91Colon cancer (HP:0003003)2.14167330
92Bilateral sensorineural hearing impairment (HP:0008619)2.13870694
93Abnormal pancreas size (HP:0012094)2.13223703
94Menorrhagia (HP:0000132)2.12576237
95Mutism (HP:0002300)2.09322218
96Abnormality of ocular smooth pursuit (HP:0000617)2.09321287
97Abnormality of the corticospinal tract (HP:0002492)2.08588657
98Vaginal atresia (HP:0000148)2.05720755
99Fair hair (HP:0002286)2.05653486
100Proximal tubulopathy (HP:0000114)2.04313954
101Genital tract atresia (HP:0001827)2.03724636
102Truncal obesity (HP:0001956)2.02979000
103Spastic gait (HP:0002064)2.02332136
104Impaired vibration sensation in the lower limbs (HP:0002166)2.02229564
105Nephroblastoma (Wilms tumor) (HP:0002667)2.01351997
106Abnormality of the lower motor neuron (HP:0002366)2.00938057
107Lower limb muscle weakness (HP:0007340)2.00914807
108Clonus (HP:0002169)2.00760018
109Upper limb muscle weakness (HP:0003484)1.99731609
110Impaired smooth pursuit (HP:0007772)1.99102443
111Poor eye contact (HP:0000817)1.98945036
112Neoplasm of the small intestine (HP:0100833)1.97519961
113Type II lissencephaly (HP:0007260)1.97439543
114Molar tooth sign on MRI (HP:0002419)1.97439294
115Abnormality of midbrain morphology (HP:0002418)1.97439294
116Ketoacidosis (HP:0001993)1.97189516
117Aplasia/Hypoplasia of the tibia (HP:0005772)1.95508054
118Embryonal renal neoplasm (HP:0011794)1.94361559
119Oligomenorrhea (HP:0000876)1.94009070
120Left ventricular hypertrophy (HP:0001712)1.93816035
121Increased nuchal translucency (HP:0010880)1.93431744
122Urinary urgency (HP:0000012)1.93222460
123Specific learning disability (HP:0001328)1.92958153
124Impaired social interactions (HP:0000735)1.91849600
125Abnormal social behavior (HP:0012433)1.91849600
126Hypoglycemic seizures (HP:0002173)1.90999749
127Pancreatic islet-cell hyperplasia (HP:0004510)1.90756808
128Hyperglycinemia (HP:0002154)1.90330849
129Prolonged QT interval (HP:0001657)1.90092981
130Hyperglycinuria (HP:0003108)1.89066902
131Amblyopia (HP:0000646)1.88459502
132Intention tremor (HP:0002080)1.87735368
133Abnormal biliary tract morphology (HP:0012440)1.87674250
134Abnormal auditory evoked potentials (HP:0006958)1.87603749
135Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.87481359
136Hemiplegia (HP:0002301)1.87390396
137Polyphagia (HP:0002591)1.86378162
138Abnormality of the renal medulla (HP:0100957)1.85920867
139Abnormal platelet volume (HP:0011876)1.85417965
140Hypobetalipoproteinemia (HP:0003563)1.84768415
141Aplasia/Hypoplasia of the sternum (HP:0006714)1.84588476
142Hypoventilation (HP:0002791)1.83411677
143Calf muscle hypertrophy (HP:0008981)1.83102964
144Abnormality of the common coagulation pathway (HP:0010990)1.83001374
145Abnormality of the calf musculature (HP:0001430)1.82656950
146Congenital sensorineural hearing impairment (HP:0008527)1.81913217
147Abnormality of the labia (HP:0000058)1.81831188
148Tubulointerstitial nephritis (HP:0001970)1.81331645
149Postural tremor (HP:0002174)1.79520873
150Rigidity (HP:0002063)1.79334388
151Lissencephaly (HP:0001339)1.78403554
152Widely spaced teeth (HP:0000687)1.78069743
153Muscle hypertrophy of the lower extremities (HP:0008968)1.77731079
154Abnormality of serine family amino acid metabolism (HP:0010894)1.76809652
155Abnormality of glycine metabolism (HP:0010895)1.76809652
156Abnormal EKG (HP:0003115)1.76643531
157Resting tremor (HP:0002322)1.76629327
158Poor coordination (HP:0002370)1.76365536
159Gait ataxia (HP:0002066)1.75703183
160Transitional cell carcinoma of the bladder (HP:0006740)1.74347725
161Microglossia (HP:0000171)1.72783665
162Nemaline bodies (HP:0003798)1.72415602
163Hip dysplasia (HP:0001385)1.71973622
164Anteriorly placed anus (HP:0001545)1.70611767
165Muscle fiber inclusion bodies (HP:0100299)1.70342866
166Curly hair (HP:0002212)1.69723039
167Abnormality of chromosome stability (HP:0003220)1.69368693
168Abnormal lung lobation (HP:0002101)1.67599288
169Hypoglycemic coma (HP:0001325)1.67470908
170Conjugated hyperbilirubinemia (HP:0002908)1.64658990
171Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.63353246
172Poikilocytosis (HP:0004447)1.63111782
173Exercise-induced muscle cramps (HP:0003710)1.62736880
174Amyotrophic lateral sclerosis (HP:0007354)1.61897753
175Gonadotropin excess (HP:0000837)1.61843954
176Choroideremia (HP:0001139)1.60976245
177Tubular atrophy (HP:0000092)1.60931380
178Aplasia/Hypoplasia of the spleen (HP:0010451)1.56772307
179Bladder carcinoma (HP:0002862)1.56370363
180Bladder neoplasm (HP:0009725)1.56370363
181Frequent falls (HP:0002359)1.56284546

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.99118195
2MAP3K93.64145515
3STK393.05729759
4MAP3K42.91637345
5MARK12.86920187
6PIK3CG2.64460215
7OBSCN2.63854739
8MINK12.53996554
9STK38L2.50236103
10MAP2K72.42116974
11PNCK2.34036982
12ACVR1B2.17035225
13NTRK22.15331579
14TRIM282.04653638
15MST41.99816634
16CASK1.96645704
17EPHA41.95151997
18PRKD31.89914659
19STK31.84629098
20MAP3K21.84033445
21SRPK11.82268730
22BRSK21.78897035
23MAP2K41.65659044
24MAP2K61.64093243
25BRD41.61941400
26KSR21.61908749
27WNK31.61589916
28LATS11.59603810
29PIK3CA1.58766403
30PHKG21.57209788
31PHKG11.57209788
32PLK21.55341614
33KSR11.52717624
34NTRK11.51491184
35TEC1.50073880
36CAMK1G1.49583168
37MAP3K51.48792341
38EIF2AK31.46929431
39CAMKK21.45431072
40PAK31.45075380
41PAK61.44640644
42MAP3K121.38889610
43GRK51.36647293
44INSRR1.34059343
45MAP3K131.32448550
46FER1.30140852
47SGK4941.22692206
48SGK2231.22692206
49CDK51.22415947
50TNIK1.14649263
51RET1.14454234
52FRK1.12681508
53CAMK2A1.08262819
54MAPK131.06823322
55PINK11.05779897
56CAMKK11.03680745
57ARAF1.01521960
58ZAK1.01344577
59PDK41.00286098
60PDK31.00286098
61FGFR20.97250135
62SGK20.97109016
63PRKCG0.96643257
64NUAK10.96441046
65STK380.95516532
66NLK0.94952732
67PTK2B0.93562101
68PRKCE0.92722097
69CSNK1A1L0.92543922
70RIPK40.90891083
71CAMK2D0.90759957
72AKT30.90668234
73BCR0.90595389
74SIK20.89842330
75DAPK20.89379899
76RIPK10.88760460
77NEK60.83533203
78UHMK10.83360299
79DMPK0.83206696
80SCYL20.81698449
81PRPF4B0.81186390
82CAMK1D0.80890125
83SIK30.79684468
84PBK0.78622961
85ERBB30.77538499
86MAPK150.77464824
87PLK30.76049622
88EIF2AK10.74971335
89CAMK2B0.74882966
90TTK0.74621755
91CSNK1G20.74560160
92STK240.74115034
93CAMK10.73812265
94CCNB10.73361080
95MKNK20.72287454
96PRKCH0.71930451
97PLK40.71880110
98ATM0.71767197
99NEK90.71516934
100FES0.70063870
101FGFR30.69436338
102FGFR10.68216123
103YES10.67664655
104CSNK1G10.66547327
105CDC42BPA0.66405971
106DYRK1A0.65346615
107NEK10.62907552
108MET0.62629802
109TYRO30.61735577
110SGK30.61659204
111MAP3K60.61452506
112TXK0.61339801
113MUSK0.61265527
114SGK10.60705399
115MAP3K10.59751408
116WNK40.59469209
117CDK30.58452780
118PDGFRA0.58333280
119BMPR1B0.56611399
120PDK10.55224855
121CDK180.54874520
122TAOK30.54797079
123CDK140.54296200
124RPS6KA30.54223835
125OXSR10.53744033
126TSSK60.52076014
127PKN10.51943370
128LMTK20.51492182
129PTK20.51408343
130BMPR20.50700363
131MST1R0.49852156
132DYRK1B0.49571013
133MAP3K70.49464888
134CAMK2G0.49419443
135EPHA30.49342281
136MAP2K10.49253525
137PLK10.49103954
138CDK150.49077279
139CAMK40.48652920
140PDPK10.48238306
141MKNK10.47603711
142CSNK1E0.47092018
143IRAK10.46955920
144MAPK100.46930633
145RAF10.45751744
146MYLK0.45375663
147IRAK20.45265002
148TAF10.45247322
149HIPK20.44911090
150DAPK10.44892868
151PRKAA10.43530443
152PRKG10.41938868
153PRKAA20.39296336
154WEE10.39209558
155RPS6KB10.38006083

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.42101985
2Propanoate metabolism_Homo sapiens_hsa006403.32434889
3Synaptic vesicle cycle_Homo sapiens_hsa047213.25273037
4Non-homologous end-joining_Homo sapiens_hsa034503.05966371
5GABAergic synapse_Homo sapiens_hsa047272.88708459
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.55780943
7Circadian entrainment_Homo sapiens_hsa047132.50628918
8Insulin secretion_Homo sapiens_hsa049112.49133192
9Morphine addiction_Homo sapiens_hsa050322.36895048
10Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.26337609
11Amphetamine addiction_Homo sapiens_hsa050312.22883934
12Glutamatergic synapse_Homo sapiens_hsa047242.16793137
13Long-term potentiation_Homo sapiens_hsa047202.10665425
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03744602
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02055117
16Dopaminergic synapse_Homo sapiens_hsa047282.01933481
17Collecting duct acid secretion_Homo sapiens_hsa049661.92391886
18Cholinergic synapse_Homo sapiens_hsa047251.89823287
19Serotonergic synapse_Homo sapiens_hsa047261.89039221
20Olfactory transduction_Homo sapiens_hsa047401.84390939
21Cocaine addiction_Homo sapiens_hsa050301.80753442
22Salivary secretion_Homo sapiens_hsa049701.78786353
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.76169048
24Renin secretion_Homo sapiens_hsa049241.75853919
25Fanconi anemia pathway_Homo sapiens_hsa034601.72523149
26Taste transduction_Homo sapiens_hsa047421.66315908
27Long-term depression_Homo sapiens_hsa047301.64005458
28Fatty acid degradation_Homo sapiens_hsa000711.59190041
29Steroid biosynthesis_Homo sapiens_hsa001001.56629631
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55419388
31Vibrio cholerae infection_Homo sapiens_hsa051101.54528665
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.53429438
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52133462
34Gastric acid secretion_Homo sapiens_hsa049711.51349614
35Oxytocin signaling pathway_Homo sapiens_hsa049211.50484101
36Platelet activation_Homo sapiens_hsa046111.47486919
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46718113
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.40894889
39Phototransduction_Homo sapiens_hsa047441.40843871
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40292351
41Basal transcription factors_Homo sapiens_hsa030221.40249942
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.37107515
43Pyruvate metabolism_Homo sapiens_hsa006201.36627014
44Type II diabetes mellitus_Homo sapiens_hsa049301.35998606
45Fatty acid metabolism_Homo sapiens_hsa012121.34930733
46Calcium signaling pathway_Homo sapiens_hsa040201.34601812
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.32426255
48Mismatch repair_Homo sapiens_hsa034301.30477539
49Cardiac muscle contraction_Homo sapiens_hsa042601.29800831
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.29270021
51Arginine and proline metabolism_Homo sapiens_hsa003301.26263184
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26139009
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.24997264
54Pentose and glucuronate interconversions_Homo sapiens_hsa000401.24682489
55Gap junction_Homo sapiens_hsa045401.23062913
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17176515
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14923855
58Circadian rhythm_Homo sapiens_hsa047101.14134920
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13515571
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12224451
61Fatty acid biosynthesis_Homo sapiens_hsa000611.11776525
62Dilated cardiomyopathy_Homo sapiens_hsa054141.08647859
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07897247
64Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07128279
65Vascular smooth muscle contraction_Homo sapiens_hsa042701.06710691
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06579821
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06146467
68GnRH signaling pathway_Homo sapiens_hsa049121.05524356
69cAMP signaling pathway_Homo sapiens_hsa040241.05488735
70TGF-beta signaling pathway_Homo sapiens_hsa043501.03861245
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02939674
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00559661
73Estrogen signaling pathway_Homo sapiens_hsa049150.98018300
74Thyroid hormone synthesis_Homo sapiens_hsa049180.96426728
75beta-Alanine metabolism_Homo sapiens_hsa004100.95522987
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94660287
77Glucagon signaling pathway_Homo sapiens_hsa049220.94617719
78Pancreatic secretion_Homo sapiens_hsa049720.87132696
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87000187
80Linoleic acid metabolism_Homo sapiens_hsa005910.86965363
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85948124
82Adherens junction_Homo sapiens_hsa045200.84707118
83Starch and sucrose metabolism_Homo sapiens_hsa005000.84290531
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83227918
85Cell cycle_Homo sapiens_hsa041100.82941686
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80715915
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79902172
88Fatty acid elongation_Homo sapiens_hsa000620.78885921
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78583347
90Melanogenesis_Homo sapiens_hsa049160.78539936
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77847420
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77845133
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77243785
94Dorso-ventral axis formation_Homo sapiens_hsa043200.74684003
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73847787
96Axon guidance_Homo sapiens_hsa043600.73366017
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.72628241
98Nucleotide excision repair_Homo sapiens_hsa034200.71983524
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70965376
100Histidine metabolism_Homo sapiens_hsa003400.70927444
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69740835
102Retinol metabolism_Homo sapiens_hsa008300.69319471
103Type I diabetes mellitus_Homo sapiens_hsa049400.69315983
104Tryptophan metabolism_Homo sapiens_hsa003800.68611068
105ABC transporters_Homo sapiens_hsa020100.67964717
106RNA transport_Homo sapiens_hsa030130.67638610
107Regulation of autophagy_Homo sapiens_hsa041400.66728104
108Peroxisome_Homo sapiens_hsa041460.66721302
109Hippo signaling pathway_Homo sapiens_hsa043900.62976187
110Oxidative phosphorylation_Homo sapiens_hsa001900.62845499
111Inositol phosphate metabolism_Homo sapiens_hsa005620.62607752
112Fat digestion and absorption_Homo sapiens_hsa049750.61437620
113Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61324345
114Tight junction_Homo sapiens_hsa045300.61262462
115Alzheimers disease_Homo sapiens_hsa050100.60582443
116Oocyte meiosis_Homo sapiens_hsa041140.59788858
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.59437858
118RNA degradation_Homo sapiens_hsa030180.59249681
119Base excision repair_Homo sapiens_hsa034100.59187890
120ErbB signaling pathway_Homo sapiens_hsa040120.56548782
121Nitrogen metabolism_Homo sapiens_hsa009100.55894034
122Alcoholism_Homo sapiens_hsa050340.55513801
123Chemical carcinogenesis_Homo sapiens_hsa052040.55268974
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54331577
125Prion diseases_Homo sapiens_hsa050200.52825977
126Protein export_Homo sapiens_hsa030600.52165080
127Choline metabolism in cancer_Homo sapiens_hsa052310.51991221
128Butanoate metabolism_Homo sapiens_hsa006500.51909474
129Glioma_Homo sapiens_hsa052140.51689469
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51546965
131Insulin signaling pathway_Homo sapiens_hsa049100.50620217
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50587655
133MAPK signaling pathway_Homo sapiens_hsa040100.50001931
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48228041
135Lysine degradation_Homo sapiens_hsa003100.46367320
136PPAR signaling pathway_Homo sapiens_hsa033200.46195264
137Colorectal cancer_Homo sapiens_hsa052100.45752949
138Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45466444
139Ovarian steroidogenesis_Homo sapiens_hsa049130.44893526
140Purine metabolism_Homo sapiens_hsa002300.44808070
141Ether lipid metabolism_Homo sapiens_hsa005650.44547503
142Selenocompound metabolism_Homo sapiens_hsa004500.43410743
143mRNA surveillance pathway_Homo sapiens_hsa030150.41691152
144Lysosome_Homo sapiens_hsa041420.41676426
145Ras signaling pathway_Homo sapiens_hsa040140.40436183
146Parkinsons disease_Homo sapiens_hsa050120.39841460
147Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39234590
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38165657
149Rheumatoid arthritis_Homo sapiens_hsa053230.37633860
150Phagosome_Homo sapiens_hsa041450.37471763
151Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36494769
152Bile secretion_Homo sapiens_hsa049760.34479774
153Sulfur metabolism_Homo sapiens_hsa009200.34172708
154Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33717044
155Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33653481
156Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33388149
157Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32475030
158Rap1 signaling pathway_Homo sapiens_hsa040150.31846573
159Endocytosis_Homo sapiens_hsa041440.31473514
160N-Glycan biosynthesis_Homo sapiens_hsa005100.30257451
161Renal cell carcinoma_Homo sapiens_hsa052110.30169225

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