ATAD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.61695256
2nuclear pore organization (GO:0006999)5.42475206
3protein localization to kinetochore (GO:0034501)5.40004233
4DNA unwinding involved in DNA replication (GO:0006268)5.28457976
5mitotic chromosome condensation (GO:0007076)5.21241251
6kinetochore organization (GO:0051383)5.13662217
7mitotic sister chromatid cohesion (GO:0007064)4.85640890
8protein localization to chromosome, centromeric region (GO:0071459)4.75049202
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.69006086
10DNA strand elongation involved in DNA replication (GO:0006271)4.68079917
11DNA replication initiation (GO:0006270)4.64054194
12sister chromatid segregation (GO:0000819)4.59754486
13mitotic sister chromatid segregation (GO:0000070)4.49473542
14telomere maintenance via semi-conservative replication (GO:0032201)4.48293524
15DNA strand elongation (GO:0022616)4.45780701
16mitotic recombination (GO:0006312)4.38147128
17pore complex assembly (GO:0046931)4.34268862
18DNA replication checkpoint (GO:0000076)4.32616024
19chromatin remodeling at centromere (GO:0031055)4.29202198
20telomere maintenance via recombination (GO:0000722)4.26299594
21attachment of spindle microtubules to kinetochore (GO:0008608)4.25757481
22mitotic metaphase plate congression (GO:0007080)4.25347769
23CENP-A containing nucleosome assembly (GO:0034080)4.23646006
24DNA replication-dependent nucleosome organization (GO:0034723)4.19733758
25DNA replication-dependent nucleosome assembly (GO:0006335)4.19733758
26mitotic nuclear envelope disassembly (GO:0007077)4.18455807
27kinetochore assembly (GO:0051382)4.17946079
28meiotic chromosome segregation (GO:0045132)4.15096215
29regulation of DNA endoreduplication (GO:0032875)4.10691291
30metaphase plate congression (GO:0051310)3.98646078
31DNA replication-independent nucleosome organization (GO:0034724)3.95650640
32DNA replication-independent nucleosome assembly (GO:0006336)3.95650640
33nuclear envelope disassembly (GO:0051081)3.89800359
34membrane disassembly (GO:0030397)3.89800359
35regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.85459885
36DNA geometric change (GO:0032392)3.81184218
37regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.80101852
38DNA duplex unwinding (GO:0032508)3.79751570
39regulation of spindle organization (GO:0090224)3.73872915
40regulation of sister chromatid cohesion (GO:0007063)3.73158084
41positive regulation of mitotic sister chromatid separation (GO:1901970)3.72012777
42positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.72012777
43positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.72012777
44regulation of histone H3-K9 methylation (GO:0051570)3.71696566
45telomere maintenance via telomere lengthening (GO:0010833)3.69334785
46double-strand break repair via nonhomologous end joining (GO:0006303)3.67975907
47non-recombinational repair (GO:0000726)3.67975907
48nucleotide-excision repair, DNA gap filling (GO:0006297)3.67250155
49translesion synthesis (GO:0019985)3.66526324
50establishment of chromosome localization (GO:0051303)3.65152729
51chromatin assembly or disassembly (GO:0006333)3.64815896
52histone exchange (GO:0043486)3.64698218
53positive regulation of chromosome segregation (GO:0051984)3.60374850
54establishment of integrated proviral latency (GO:0075713)3.56210215
55protein localization to chromosome (GO:0034502)3.54305193
56chromosome condensation (GO:0030261)3.52333801
57chromosome segregation (GO:0007059)3.51836263
58dosage compensation (GO:0007549)3.51660835
59DNA topological change (GO:0006265)3.49885215
60DNA ligation (GO:0006266)3.49702230
61regulation of translational fidelity (GO:0006450)3.49180849
62regulation of centriole replication (GO:0046599)3.47387292
63IMP biosynthetic process (GO:0006188)3.47334146
64protein K6-linked ubiquitination (GO:0085020)3.45104555
65regulation of chromosome segregation (GO:0051983)3.42875822
66DNA conformation change (GO:0071103)3.42513684
67regulation of centrosome cycle (GO:0046605)3.42347395
68spindle checkpoint (GO:0031577)3.39771380
69regulation of mitotic spindle organization (GO:0060236)3.38503916
70regulation of mitotic metaphase/anaphase transition (GO:0030071)3.37112557
71chromatin assembly (GO:0031497)3.35382469
72maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.35381619
73negative regulation of DNA-dependent DNA replication (GO:2000104)3.34893169
74microtubule depolymerization (GO:0007019)3.33571223
75postreplication repair (GO:0006301)3.31914163
76DNA packaging (GO:0006323)3.31257141
77regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.28749529
78DNA synthesis involved in DNA repair (GO:0000731)3.27343619
79heterochromatin organization (GO:0070828)3.26560083
80spindle assembly checkpoint (GO:0071173)3.23994995
81telomere maintenance (GO:0000723)3.22824219
82negative regulation of chromosome segregation (GO:0051985)3.19618557
83folic acid-containing compound biosynthetic process (GO:0009396)3.19579794
84telomere organization (GO:0032200)3.19469879
85formation of translation preinitiation complex (GO:0001731)3.19341823
86regulation of RNA export from nucleus (GO:0046831)3.18407130
87ATP-dependent chromatin remodeling (GO:0043044)3.18308332
88mitotic cell cycle (GO:0000278)3.17916218
89regulation of sister chromatid segregation (GO:0033045)3.17126810
90regulation of mitotic sister chromatid separation (GO:0010965)3.17126810
91regulation of mitotic sister chromatid segregation (GO:0033047)3.17126810
92negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.14681278
93negative regulation of sister chromatid segregation (GO:0033046)3.14681278
94negative regulation of mitotic sister chromatid separation (GO:2000816)3.14681278
95negative regulation of mitotic sister chromatid segregation (GO:0033048)3.14681278
96negative regulation of DNA repair (GO:0045738)3.13336867
97positive regulation of DNA-dependent DNA replication (GO:2000105)3.12317524
98deoxyribonucleotide biosynthetic process (GO:0009263)3.10993487
99regulation of nuclear cell cycle DNA replication (GO:0033262)3.08821092
100negative regulation of histone methylation (GO:0031061)3.08387929
101replication fork processing (GO:0031297)3.08355119
102mitotic spindle assembly checkpoint (GO:0007094)3.07880175
103positive regulation of cell cycle checkpoint (GO:1901978)3.07367639
104mitotic spindle checkpoint (GO:0071174)3.06655358
105IMP metabolic process (GO:0046040)3.05556012
106nucleobase biosynthetic process (GO:0046112)3.04968554
107negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.04518279
108sister chromatid cohesion (GO:0007062)3.03284244
109regulation of centrosome duplication (GO:0010824)3.02612318
110chromosome organization (GO:0051276)3.02013745
111nuclear envelope organization (GO:0006998)3.02010341
112mismatch repair (GO:0006298)3.01887179
113somatic hypermutation of immunoglobulin genes (GO:0016446)3.00870111
114spindle assembly involved in mitosis (GO:0090307)3.00799783
115ribosome assembly (GO:0042255)2.99824758
116DNA replication (GO:0006260)2.97695454
117V(D)J recombination (GO:0033151)2.97143018
118regulation of double-strand break repair (GO:2000779)2.96595427
119nucleobase-containing small molecule interconversion (GO:0015949)2.94084075
120DNA strand renaturation (GO:0000733)2.92233825
121microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.91612267
122spindle organization (GO:0007051)2.90374707
123spliceosomal tri-snRNP complex assembly (GO:0000244)2.89830257
124spindle assembly (GO:0051225)2.87761878
125regulation of double-strand break repair via homologous recombination (GO:0010569)2.87338079

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human6.19002182
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.98194597
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.89821257
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.38894579
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.14221037
6* E2F1_21310950_ChIP-Seq_MCF-7_Human2.71764357
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.61043712
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.60200879
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.59722032
10* AR_21909140_ChIP-Seq_LNCAP_Human2.55417702
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.38487647
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34556749
13* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18255821
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.11211836
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.09270508
16MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08034363
17* E2F7_22180533_ChIP-Seq_HELA_Human12.0377750
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.99496063
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.92523587
20EST1_17652178_ChIP-ChIP_JURKAT_Human1.91756214
21CREB1_15753290_ChIP-ChIP_HEK293T_Human1.80290989
22XRN2_22483619_ChIP-Seq_HELA_Human1.78706959
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.78249856
24MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77268643
25MYC_22102868_ChIP-Seq_BL_Human1.75532958
26VDR_23849224_ChIP-Seq_CD4+_Human1.73148316
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.73105924
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72889973
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71493092
30ELK1_19687146_ChIP-ChIP_HELA_Human1.69566820
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65929039
32* FOXP3_21729870_ChIP-Seq_TREG_Human1.57694191
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54853547
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.53788151
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53711677
36ZNF263_19887448_ChIP-Seq_K562_Human1.49790447
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47859198
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.47062143
39TTF2_22483619_ChIP-Seq_HELA_Human1.46437683
40* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45460711
41CIITA_25753668_ChIP-Seq_RAJI_Human1.44037574
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41875505
43DCP1A_22483619_ChIP-Seq_HELA_Human1.40461556
44* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40300155
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38405720
46* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35618047
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34556545
48KDM5A_27292631_Chip-Seq_BREAST_Human1.33859854
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32631957
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32055963
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30768735
52* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30151425
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29504988
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.27977824
55* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27969075
56GABP_19822575_ChIP-Seq_HepG2_Human1.24184021
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23438290
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.19992500
59E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18857461
60ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15959091
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14228331
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13411441
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12942467
64TFEB_21752829_ChIP-Seq_HELA_Human1.11306009
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09063984
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04763438
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02564358
68VDR_21846776_ChIP-Seq_THP-1_Human1.02529343
69* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02225003
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01520759
71SOX17_20123909_ChIP-Seq_XEN_Mouse1.00834551
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00645004
73* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00587995
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98981601
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98900618
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97328301
77PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96057682
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94856861
79SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93526386
80* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92365295
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92253284
82* SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91588570
83STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91204576
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90883537
85* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89075486
86MYC_18940864_ChIP-ChIP_HL60_Human0.88306536
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87139523
88SPI1_23547873_ChIP-Seq_NB4_Human0.86188672
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85318181
90NANOG_21062744_ChIP-ChIP_HESCs_Human0.82748883
91POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.82275264
92TP63_17297297_ChIP-ChIP_HaCaT_Human0.81979177
93* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80901187
94NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.80891314
95* MYB_26560356_Chip-Seq_TH1_Human0.78673026
96MYB_26560356_Chip-Seq_TH2_Human0.77699569
97ATF3_27146783_Chip-Seq_COLON_Human0.74672380
98SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.74340893
99EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.74209865
100* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.73756851
101MYB_21317192_ChIP-Seq_ERMYB_Mouse0.72945908
102CHD1_26751641_Chip-Seq_LNCaP_Human0.72743707
103PKCTHETA_26484144_Chip-Seq_BREAST_Human0.72711521
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.72597295
105FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.72502913
106TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72449380
107FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.72341142
108ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.72103164
109FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.72042045
110HIF1A_21447827_ChIP-Seq_MCF-7_Human0.70758222
111GATA6_25053715_ChIP-Seq_YYC3_Human0.70705755
112CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70256205
113UTX_26944678_Chip-Seq_JUKART_Human0.68645915
114BRD4_27068464_Chip-Seq_AML-cells_Mouse0.67479740
115NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.67265443
116TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.66293892
117* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.66171647
118* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.65680392
119* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.65643517

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.85090485
2MP0008057_abnormal_DNA_replication4.45045172
3MP0003693_abnormal_embryo_hatching4.19836211
4MP0003111_abnormal_nucleus_morphology4.10210089
5MP0003077_abnormal_cell_cycle3.74300725
6MP0004957_abnormal_blastocyst_morpholog3.53739239
7MP0008058_abnormal_DNA_repair2.96033379
8MP0008877_abnormal_DNA_methylation2.83273591
9MP0010307_abnormal_tumor_latency2.71586161
10MP0010352_gastrointestinal_tract_polyps2.62072075
11MP0008007_abnormal_cellular_replicative2.61617985
12MP0002396_abnormal_hematopoietic_system2.47905409
13MP0003123_paternal_imprinting2.32365239
14MP0008932_abnormal_embryonic_tissue2.27870857
15MP0000350_abnormal_cell_proliferation2.19253322
16MP0001730_embryonic_growth_arrest2.11576568
17MP0010234_abnormal_vibrissa_follicle2.10389454
18MP0003121_genomic_imprinting2.06632169
19MP0005076_abnormal_cell_differentiation1.98736113
20MP0004185_abnormal_adipocyte_glucose1.90116089
21MP0004808_abnormal_hematopoietic_stem1.88112171
22MP0005380_embryogenesis_phenotype1.73243887
23MP0001672_abnormal_embryogenesis/_devel1.73243887
24MP0004197_abnormal_fetal_growth/weight/1.67161184
25MP0001697_abnormal_embryo_size1.66089776
26MP0000490_abnormal_crypts_of1.64391317
27MP0003984_embryonic_growth_retardation1.56601917
28MP0003786_premature_aging1.55717398
29MP0002085_abnormal_embryonic_tissue1.54186054
30MP0002088_abnormal_embryonic_growth/wei1.53639690
31MP0002084_abnormal_developmental_patter1.51401513
32MP0002086_abnormal_extraembryonic_tissu1.49830870
33MP0003890_abnormal_embryonic-extraembry1.43725442
34MP0003567_abnormal_fetal_cardiomyocyte1.41975574
35MP0002080_prenatal_lethality1.41478567
36MP0003705_abnormal_hypodermis_morpholog1.39017508
37MP0004233_abnormal_muscle_weight1.38570665
38MP0003950_abnormal_plasma_membrane1.38012056
39MP0002019_abnormal_tumor_incidence1.33516691
40MP0000313_abnormal_cell_death1.32892714
41MP0005408_hypopigmentation1.32118511
42MP0000569_abnormal_digit_pigmentation1.29744698
43MP0010030_abnormal_orbit_morphology1.28943585
44MP0004264_abnormal_extraembryonic_tissu1.28848225
45MP0006054_spinal_hemorrhage1.26938078
46MP0001346_abnormal_lacrimal_gland1.24853134
47MP0000703_abnormal_thymus_morphology1.22200445
48MP0003787_abnormal_imprinting1.20468104
49MP0009278_abnormal_bone_marrow1.19817801
50MP0001545_abnormal_hematopoietic_system1.19627087
51MP0005397_hematopoietic_system_phenotyp1.19627087
52MP0001293_anophthalmia1.17741404
53MP0002210_abnormal_sex_determination1.13435748
54MP0005451_abnormal_body_composition1.12954250
55MP0003937_abnormal_limbs/digits/tail_de1.10909299
56MP0003763_abnormal_thymus_physiology1.06749655
57MP0001661_extended_life_span1.06477494
58MP0002398_abnormal_bone_marrow1.06087632
59MP0005501_abnormal_skin_physiology1.04715503
60MP0002877_abnormal_melanocyte_morpholog1.04179084
61MP0002009_preneoplasia1.01361154
62MP0009703_decreased_birth_body0.98790784
63MP0000627_abnormal_mammary_gland0.97517632
64MP0000537_abnormal_urethra_morphology0.97194695
65MP0003941_abnormal_skin_development0.96268618
66MP0003315_abnormal_perineum_morphology0.96071839
67MP0001145_abnormal_male_reproductive0.95915436
68MP0002006_tumorigenesis0.94987153
69MP0002166_altered_tumor_susceptibility0.94077815
70MP0009053_abnormal_anal_canal0.93754751
71MP0002722_abnormal_immune_system0.93272482
72MP0000358_abnormal_cell_content/0.93037668
73MP0003806_abnormal_nucleotide_metabolis0.92355859
74MP0010678_abnormal_skin_adnexa0.91818150
75MP0009672_abnormal_birth_weight0.91490855
76MP0009333_abnormal_splenocyte_physiolog0.90623463
77MP0000733_abnormal_muscle_development0.90536448
78MP0001915_intracranial_hemorrhage0.90317413
79MP0003566_abnormal_cell_adhesion0.90206676
80MP0000689_abnormal_spleen_morphology0.86136256
81MP0003221_abnormal_cardiomyocyte_apopto0.85667901
82MP0001929_abnormal_gametogenesis0.85380916
83MP0001348_abnormal_lacrimal_gland0.83074260
84MP0000653_abnormal_sex_gland0.81538256
85MP0005023_abnormal_wound_healing0.79406816
86MP0000432_abnormal_head_morphology0.79225679
87MP0001119_abnormal_female_reproductive0.79038141
88MP0002796_impaired_skin_barrier0.78888316
89MP0000428_abnormal_craniofacial_morphol0.78831912
90MP0002092_abnormal_eye_morphology0.77746465
91MP0003935_abnormal_craniofacial_develop0.77548732
92MP0002095_abnormal_skin_pigmentation0.77037369
93MP0002111_abnormal_tail_morphology0.76806721
94MP0002060_abnormal_skin_morphology0.76703718
95MP0001881_abnormal_mammary_gland0.76037143
96MP0002098_abnormal_vibrissa_morphology0.75719549
97MP0005621_abnormal_cell_physiology0.74725370
98MP0003699_abnormal_female_reproductive0.74130390
99MP0001216_abnormal_epidermal_layer0.73453028
100MP0002970_abnormal_white_adipose0.73324410
101MP0003656_abnormal_erythrocyte_physiolo0.72771265
102MP0005384_cellular_phenotype0.72578420
103MP0002429_abnormal_blood_cell0.72455229
104MP0002925_abnormal_cardiovascular_devel0.72205943
105MP0002075_abnormal_coat/hair_pigmentati0.70896227
106MP0002697_abnormal_eye_size0.70169940
107MP0003115_abnormal_respiratory_system0.69141743
108MP0005174_abnormal_tail_pigmentation0.68784673
109MP0000858_altered_metastatic_potential0.68668640
110MP0000377_abnormal_hair_follicle0.66376116
111MP0005623_abnormal_meninges_morphology0.66324698
112MP0003718_maternal_effect0.66296269
113MP0001286_abnormal_eye_development0.65833920
114MP0003448_altered_tumor_morphology0.64948766
115MP0000566_synostosis0.64668386
116MP0003755_abnormal_palate_morphology0.64613784
117MP0000716_abnormal_immune_system0.64070691
118MP0000427_abnormal_hair_cycle0.64061719
119MP0002938_white_spotting0.63271411
120MP0001873_stomach_inflammation0.63109115
121MP0006035_abnormal_mitochondrial_morpho0.62759706
122MP0000371_diluted_coat_color0.61005410
123MP0002269_muscular_atrophy0.60656500
124MP0002234_abnormal_pharynx_morphology0.60537259
125MP0005666_abnormal_adipose_tissue0.59800367
126MP0003119_abnormal_digestive_system0.59374414
127MP0001186_pigmentation_phenotype0.59359058
128MP0000477_abnormal_intestine_morphology0.59085270
129MP0000015_abnormal_ear_pigmentation0.58491023
130MP0005409_darkened_coat_color0.57744447
131MP0000383_abnormal_hair_follicle0.55792595
132MP0009697_abnormal_copulation0.55726309
133MP0003943_abnormal_hepatobiliary_system0.55580331
134MP0002160_abnormal_reproductive_system0.55070290

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.02980369
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.65559522
3Volvulus (HP:0002580)4.15254783
4Abnormality of chromosome stability (HP:0003220)3.92073331
5Birth length less than 3rd percentile (HP:0003561)3.71902242
6Ectopic kidney (HP:0000086)3.31010662
7Meckel diverticulum (HP:0002245)3.25152380
8Increased nuchal translucency (HP:0010880)3.12705136
9Abnormality of the ileum (HP:0001549)3.11941583
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.09845971
11Abnormality of the preputium (HP:0100587)3.07212131
12Medulloblastoma (HP:0002885)3.02541080
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.99036869
14Short 4th metacarpal (HP:0010044)2.99036869
15Impulsivity (HP:0100710)2.89090562
16Reticulocytopenia (HP:0001896)2.88093079
17Selective tooth agenesis (HP:0001592)2.79810822
18Overlapping toe (HP:0001845)2.78189948
19Colon cancer (HP:0003003)2.76861682
20Ependymoma (HP:0002888)2.76683421
21Duodenal stenosis (HP:0100867)2.76480711
22Small intestinal stenosis (HP:0012848)2.76480711
23Myelodysplasia (HP:0002863)2.76159168
24Deviation of the thumb (HP:0009603)2.73377285
25Proximal placement of thumb (HP:0009623)2.73006316
26Microglossia (HP:0000171)2.69853984
27Patellar aplasia (HP:0006443)2.66627324
28Agnosia (HP:0010524)2.58415587
29Rhabdomyosarcoma (HP:0002859)2.57108156
30Abnormality of the carotid arteries (HP:0005344)2.52279207
31Poikiloderma (HP:0001029)2.51386174
32Abnormality of the fingertips (HP:0001211)2.48489091
33Abnormality of the labia minora (HP:0012880)2.44407671
34Absent radius (HP:0003974)2.44396839
35Aplasia/Hypoplasia of the patella (HP:0006498)2.43892818
36Asymmetry of the thorax (HP:0001555)2.37593787
37Insidious onset (HP:0003587)2.36990889
38Termporal pattern (HP:0011008)2.36990889
39Breast hypoplasia (HP:0003187)2.34162537
40Facial hemangioma (HP:0000329)2.33095508
41Long eyelashes (HP:0000527)2.32829473
42Nephroblastoma (Wilms tumor) (HP:0002667)2.31080369
43Abnormality of the duodenum (HP:0002246)2.30473448
44Choanal atresia (HP:0000453)2.30373907
45Absent thumb (HP:0009777)2.28810706
46Sloping forehead (HP:0000340)2.28604540
47Cafe-au-lait spot (HP:0000957)2.28583414
48Ankyloglossia (HP:0010296)2.28095623
49Hyperacusis (HP:0010780)2.26171608
50Prominent nose (HP:0000448)2.26070506
51Aplasia involving forearm bones (HP:0009822)2.25726110
52Absent forearm bone (HP:0003953)2.25726110
53Atresia of the external auditory canal (HP:0000413)2.24172790
54High pitched voice (HP:0001620)2.22977633
55Abnormality of the astrocytes (HP:0100707)2.22754772
56Astrocytoma (HP:0009592)2.22754772
57Duplicated collecting system (HP:0000081)2.21656540
58Septate vagina (HP:0001153)2.18627166
59Heterotopia (HP:0002282)2.15711093
60Embryonal renal neoplasm (HP:0011794)2.14875400
61Glioma (HP:0009733)2.13836919
62Abnormal lung lobation (HP:0002101)2.13262871
63Embryonal neoplasm (HP:0002898)2.13047749
64Aplasia/Hypoplasia of the sacrum (HP:0008517)2.13010567
65Clubbing of toes (HP:0100760)2.12684351
66Basal cell carcinoma (HP:0002671)2.11028951
67Cortical dysplasia (HP:0002539)2.09347145
68Abnormal number of incisors (HP:0011064)2.09182205
69Short thumb (HP:0009778)2.08345408
70Deep philtrum (HP:0002002)2.07581282
71Microvesicular hepatic steatosis (HP:0001414)2.06945115
72Bone marrow hypocellularity (HP:0005528)2.06637428
73Abnormality of cochlea (HP:0000375)2.04886929
74Abnormality of the renal collecting system (HP:0004742)2.04376097
7511 pairs of ribs (HP:0000878)2.02632819
76Abnormal foot bone ossification (HP:0010675)1.99690744
77Tracheoesophageal fistula (HP:0002575)1.98154954
78Premature graying of hair (HP:0002216)1.97235805
79Acute myeloid leukemia (HP:0004808)1.96983978
80Duplication of thumb phalanx (HP:0009942)1.96618688
81Abnormality of the 4th metacarpal (HP:0010012)1.95466454
82Multiple enchondromatosis (HP:0005701)1.95152633
83Neoplasm of the pancreas (HP:0002894)1.94303852
84Squamous cell carcinoma (HP:0002860)1.93911369
85Hypoplasia of the capital femoral epiphysis (HP:0003090)1.92916763
86Truncal obesity (HP:0001956)1.92132165
87Insomnia (HP:0100785)1.92071497
88Malignant gastrointestinal tract tumors (HP:0006749)1.91562205
89Gastrointestinal carcinoma (HP:0002672)1.91562205
90Abnormality of DNA repair (HP:0003254)1.91077997
91Neoplasm of the oral cavity (HP:0100649)1.90693114
92Aplasia/Hypoplasia of the sternum (HP:0006714)1.89652460
93Abnormality of the anterior horn cell (HP:0006802)1.89590617
94Degeneration of anterior horn cells (HP:0002398)1.89590617
95Spinal cord lesions (HP:0100561)1.88580321
96Syringomyelia (HP:0003396)1.88580321
97Neoplasm of striated muscle (HP:0009728)1.88334875
98Biliary tract neoplasm (HP:0100574)1.86017729
99Cutaneous melanoma (HP:0012056)1.85650734
100Abnormality of oral frenula (HP:0000190)1.82490786
101Lymphoma (HP:0002665)1.82352968
102Arteriovenous malformation (HP:0100026)1.80165432
103Flat acetabular roof (HP:0003180)1.79316594
104Abnormality of the umbilical cord (HP:0010881)1.78565090
105Amaurosis fugax (HP:0100576)1.78464400
106Oral leukoplakia (HP:0002745)1.76618197
107Relative macrocephaly (HP:0004482)1.76525137
108Horseshoe kidney (HP:0000085)1.76092474
109Abnormality of reticulocytes (HP:0004312)1.75684795
110Triphalangeal thumb (HP:0001199)1.75085646
111Cutis marmorata (HP:0000965)1.74983992
112Acute lymphatic leukemia (HP:0006721)1.74103316
113Sandal gap (HP:0001852)1.73833267
114Obsessive-compulsive behavior (HP:0000722)1.73644100
115Abnormality of chromosome segregation (HP:0002916)1.72660850
116Abnormality of the fetal cardiovascular system (HP:0010948)1.71535036
117Abnormal umbilical cord blood vessels (HP:0011403)1.71535036
118Single umbilical artery (HP:0001195)1.71535036
119Uterine leiomyosarcoma (HP:0002891)1.71196063
120Leiomyosarcoma (HP:0100243)1.71196063
121Hypopigmentation of the fundus (HP:0007894)1.71190843
122Orthostatic hypotension (HP:0001278)1.70748207
123High anterior hairline (HP:0009890)1.70048227
124Progressive external ophthalmoplegia (HP:0000590)1.69991830
125Microtia (HP:0008551)1.69798523
126Blepharitis (HP:0000498)1.69370557
127IgM deficiency (HP:0002850)1.69305397
128Sparse lateral eyebrow (HP:0005338)1.68843369
129Progressive muscle weakness (HP:0003323)1.68820893
130Skull defect (HP:0001362)1.67959485
131Abnormality of the calcaneus (HP:0008364)1.67209978
132Aplasia/Hypoplasia of the earlobes (HP:0009906)1.67183356
133Small epiphyses (HP:0010585)1.66056058
134Increased density of long bones (HP:0006392)1.65332487
135Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.65043632
136Broad palm (HP:0001169)1.64250893
137Missing ribs (HP:0000921)1.64049679
138Aplastic anemia (HP:0001915)1.63854284
139Supernumerary spleens (HP:0009799)1.63727457
140Limited elbow extension (HP:0001377)1.63426901
141Absent epiphyses (HP:0010577)1.63356043
142Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.63356043
143Abnormality of pyrimidine metabolism (HP:0004353)1.63219702

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.88657355
2WEE13.56507682
3NEK23.36112238
4CDK123.29574524
5SRPK12.56966057
6PBK2.55828236
7MST1R2.52199799
8TTK2.39350194
9BUB12.37681417
10ACVR1B2.33307172
11BRSK22.26598057
12NEK12.13215600
13ATR2.06123861
14SMG12.00274140
15PLK11.99964341
16AURKB1.95304232
17PASK1.95147209
18MKNK11.92563176
19TLK11.83873055
20CHEK21.82388800
21PLK41.79276040
22TRIB31.75615331
23ZAK1.73994100
24STK41.70832917
25EIF2AK11.69954615
26CDK41.65738752
27CDK71.64304074
28PLK31.62864955
29ICK1.62779452
30RPS6KA41.57794469
31BRD41.55291446
32EEF2K1.54909379
33STK101.52306310
34CDK61.51236173
35CHEK11.49744561
36VRK11.38156943
37MAP3K81.35217425
38MAP3K101.34596874
39ATM1.34279635
40MKNK21.33804991
41TAF11.33634816
42SCYL21.33359884
43STK31.33030155
44TSSK61.32401148
45RPS6KB21.32150317
46MET1.29831384
47CCNB11.28211449
48BRSK11.27316626
49PKN21.19006475
50MELK1.13703139
51PNCK1.10493202
52DYRK31.09955669
53LATS11.09251672
54IRAK31.07885172
55PIM11.05899271
56CDK21.03431698
57SIK11.02350300
58VRK20.97344408
59TGFBR10.96187124
60LATS20.94452150
61EIF2AK30.90249242
62CDK10.85992772
63CLK10.85848179
64TTN0.85132471
65AURKA0.84332714
66MST40.84325830
67MAP4K10.80485424
68PAK40.80452830
69ERBB40.77688209
70FLT30.74515973
71TRPM70.71787701
72TESK20.69667694
73CDK90.69362381
74RPS6KA50.68154021
75CDK80.66508621
76ALK0.66378820
77MTOR0.65497364
78TRIM280.65433992
79JAK30.64935638
80MAPK110.63233904
81CAMK1D0.60704089
82EIF2AK20.58734554
83PRKDC0.54178599
84CSNK2A20.54035260
85FGFR40.53730288
86NEK60.53495621
87NME20.51973752
88YES10.51886996
89LRRK20.50575879
90CAMK1G0.49212623
91STK390.48264101
92CSNK2A10.48160965
93BRAF0.48041438
94STK38L0.47574046
95MAPK140.47559411
96NUAK10.46683900
97NEK90.46446749
98CSNK1D0.46184461
99ERBB30.46157001
100BCR0.39576825
101MARK30.39143659
102AKT10.38962583
103CSF1R0.38600264
104CDK180.37489133
105AKT20.37418938
106SIK30.37099444
107KSR10.35398815
108CDK150.35285784
109FGFR10.35106293
110MAP2K30.34526105
111PAK20.34409434
112CDK11A0.32883019
113BTK0.32341962
114RAF10.32057287
115KSR20.32036914
116TEC0.31747133
117EPHA20.30674327
118CSNK1E0.30278510
119CHUK0.29889706
120MAPK10.29307912
121PRPF4B0.28641645
122GSK3B0.27211634
123PAK10.25666934
124RPS6KB10.25512164
125PDGFRA0.25140360
126RPS6KL10.24777049
127RPS6KC10.24777049
128FGFR30.23362599
129RPS6KA60.20704605
130PTK60.19743784

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.08748334
2Mismatch repair_Homo sapiens_hsa034304.34296889
3Homologous recombination_Homo sapiens_hsa034403.31602106
4Cell cycle_Homo sapiens_hsa041103.30117647
5Base excision repair_Homo sapiens_hsa034103.01001888
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.98438740
7Spliceosome_Homo sapiens_hsa030402.92176324
8RNA transport_Homo sapiens_hsa030132.91332798
9Fanconi anemia pathway_Homo sapiens_hsa034602.89246127
10Nucleotide excision repair_Homo sapiens_hsa034202.71071840
11One carbon pool by folate_Homo sapiens_hsa006702.63670299
12Non-homologous end-joining_Homo sapiens_hsa034502.59888516
13Systemic lupus erythematosus_Homo sapiens_hsa053222.18413951
14mRNA surveillance pathway_Homo sapiens_hsa030152.05374041
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.92044772
16RNA degradation_Homo sapiens_hsa030181.90020561
17p53 signaling pathway_Homo sapiens_hsa041151.86379328
18RNA polymerase_Homo sapiens_hsa030201.80899558
19Pyrimidine metabolism_Homo sapiens_hsa002401.73167644
20Basal transcription factors_Homo sapiens_hsa030221.67590820
21Ribosome_Homo sapiens_hsa030101.59088834
22Viral carcinogenesis_Homo sapiens_hsa052031.50256960
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47230619
24MicroRNAs in cancer_Homo sapiens_hsa052061.28008014
25Herpes simplex infection_Homo sapiens_hsa051681.24984291
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15847247
27Epstein-Barr virus infection_Homo sapiens_hsa051691.13935898
28Proteasome_Homo sapiens_hsa030501.12892577
29Antigen processing and presentation_Homo sapiens_hsa046121.11804900
30HTLV-I infection_Homo sapiens_hsa051661.10817170
31Small cell lung cancer_Homo sapiens_hsa052221.10051808
32Oocyte meiosis_Homo sapiens_hsa041141.08487040
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07428661
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05108564
35Alcoholism_Homo sapiens_hsa050340.97552406
36Carbon metabolism_Homo sapiens_hsa012000.96079713
37Pyruvate metabolism_Homo sapiens_hsa006200.95074210
38Cysteine and methionine metabolism_Homo sapiens_hsa002700.94739860
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88461984
40Chronic myeloid leukemia_Homo sapiens_hsa052200.84164184
41Purine metabolism_Homo sapiens_hsa002300.84068512
42Thyroid cancer_Homo sapiens_hsa052160.80395565
43Hepatitis B_Homo sapiens_hsa051610.79942745
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79450469
45Colorectal cancer_Homo sapiens_hsa052100.78509572
46NF-kappa B signaling pathway_Homo sapiens_hsa040640.77275362
47Primary immunodeficiency_Homo sapiens_hsa053400.77117022
48Adherens junction_Homo sapiens_hsa045200.76983403
49Steroid biosynthesis_Homo sapiens_hsa001000.75672249
50TGF-beta signaling pathway_Homo sapiens_hsa043500.75525946
51Vitamin B6 metabolism_Homo sapiens_hsa007500.73928715
52Lysine degradation_Homo sapiens_hsa003100.73470769
53Measles_Homo sapiens_hsa051620.73171919
54Folate biosynthesis_Homo sapiens_hsa007900.71635663
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71296825
56Prostate cancer_Homo sapiens_hsa052150.69646555
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65871338
58Glioma_Homo sapiens_hsa052140.64004458
59Viral myocarditis_Homo sapiens_hsa054160.63711021
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63547526
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63512980
62Apoptosis_Homo sapiens_hsa042100.63364206
63Selenocompound metabolism_Homo sapiens_hsa004500.63012025
64Legionellosis_Homo sapiens_hsa051340.62445745
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62417519
66Pancreatic cancer_Homo sapiens_hsa052120.60987647
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59979742
68Fatty acid biosynthesis_Homo sapiens_hsa000610.59729001
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57233229
70Non-small cell lung cancer_Homo sapiens_hsa052230.57129354
71Hippo signaling pathway_Homo sapiens_hsa043900.55643439
72Basal cell carcinoma_Homo sapiens_hsa052170.54594358
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54552405
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54097499
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53401688
76Hematopoietic cell lineage_Homo sapiens_hsa046400.51796925
77Influenza A_Homo sapiens_hsa051640.51299411
78Renal cell carcinoma_Homo sapiens_hsa052110.51102489
79Pathways in cancer_Homo sapiens_hsa052000.50273551
80Notch signaling pathway_Homo sapiens_hsa043300.50150739
81Shigellosis_Homo sapiens_hsa051310.48211046
82Bladder cancer_Homo sapiens_hsa052190.47910918
83mTOR signaling pathway_Homo sapiens_hsa041500.46297829
84Proteoglycans in cancer_Homo sapiens_hsa052050.44387077
85Fructose and mannose metabolism_Homo sapiens_hsa000510.43465902
86Leishmaniasis_Homo sapiens_hsa051400.43327793
87FoxO signaling pathway_Homo sapiens_hsa040680.41528947
88B cell receptor signaling pathway_Homo sapiens_hsa046620.41388031
89ErbB signaling pathway_Homo sapiens_hsa040120.40330369
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.39818972
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39231624
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38748515
93Fatty acid metabolism_Homo sapiens_hsa012120.38701650
94Acute myeloid leukemia_Homo sapiens_hsa052210.38484813
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.38298720
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38094214
97Melanoma_Homo sapiens_hsa052180.37908133
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37571637
99Endometrial cancer_Homo sapiens_hsa052130.37460781
100HIF-1 signaling pathway_Homo sapiens_hsa040660.34878112
101T cell receptor signaling pathway_Homo sapiens_hsa046600.34258559
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33401601
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.32991256
104N-Glycan biosynthesis_Homo sapiens_hsa005100.32937496
105Glutathione metabolism_Homo sapiens_hsa004800.32524104
106Arginine biosynthesis_Homo sapiens_hsa002200.32410591
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32050231
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.31488527
109Wnt signaling pathway_Homo sapiens_hsa043100.30945802
110Protein export_Homo sapiens_hsa030600.30739906
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.30495118
112Fatty acid elongation_Homo sapiens_hsa000620.30189797
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30114193
114Toxoplasmosis_Homo sapiens_hsa051450.29879419
115AMPK signaling pathway_Homo sapiens_hsa041520.29221121
116Pentose phosphate pathway_Homo sapiens_hsa000300.28361875
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27470128
118Propanoate metabolism_Homo sapiens_hsa006400.27386232
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.27049570
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26942672
121Focal adhesion_Homo sapiens_hsa045100.26555019
122RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26137018
123Inositol phosphate metabolism_Homo sapiens_hsa005620.25570574
124Renin-angiotensin system_Homo sapiens_hsa046140.25504928
125TNF signaling pathway_Homo sapiens_hsa046680.23996200
126Platelet activation_Homo sapiens_hsa046110.23290009
127Biosynthesis of amino acids_Homo sapiens_hsa012300.23227064
128Insulin signaling pathway_Homo sapiens_hsa049100.23044232
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22205021
130Hedgehog signaling pathway_Homo sapiens_hsa043400.22147742
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20780812
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20567409

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