ASXL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.38045049
2nuclear pore organization (GO:0006999)5.07850249
3pre-miRNA processing (GO:0031054)4.94387040
4regulation of histone H3-K27 methylation (GO:0061085)4.63728255
5protein localization to kinetochore (GO:0034501)4.43588236
6mitotic sister chromatid cohesion (GO:0007064)4.39940138
7DNA unwinding involved in DNA replication (GO:0006268)4.37421398
8negative regulation of histone methylation (GO:0031061)4.27765668
9mitotic chromosome condensation (GO:0007076)4.08552181
10regulation of RNA export from nucleus (GO:0046831)4.01337456
11pore complex assembly (GO:0046931)4.00907420
12sister chromatid segregation (GO:0000819)4.00788979
13mitotic nuclear envelope disassembly (GO:0007077)4.00515191
14heterochromatin organization (GO:0070828)3.99722710
15regulation of histone H3-K9 methylation (GO:0051570)3.98614202
16protein localization to chromosome, centromeric region (GO:0071459)3.90679772
17nuclear envelope disassembly (GO:0051081)3.82041502
18membrane disassembly (GO:0030397)3.82041502
19mitotic sister chromatid segregation (GO:0000070)3.80959111
20DNA duplex unwinding (GO:0032508)3.55939086
21DNA geometric change (GO:0032392)3.55620408
22negative regulation of erythrocyte differentiation (GO:0045647)3.51475787
23negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.49644870
24regulation of NFAT protein import into nucleus (GO:0051532)3.48239925
25embryonic process involved in female pregnancy (GO:0060136)3.47560809
26regulation of translational fidelity (GO:0006450)3.44517758
27dosage compensation (GO:0007549)3.44306563
28histone H3-K36 demethylation (GO:0070544)3.42742486
29cell-substrate adherens junction assembly (GO:0007045)3.42263109
30focal adhesion assembly (GO:0048041)3.42263109
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.39758631
32RNA stabilization (GO:0043489)3.36750745
33mRNA stabilization (GO:0048255)3.36750745
34regulation of sister chromatid cohesion (GO:0007063)3.36571155
35chromatin assembly (GO:0031497)3.34923139
36negative regulation of fatty acid transport (GO:2000192)3.32820243
37regulation of posttranscriptional gene silencing (GO:0060147)3.32283875
38regulation of gene silencing by miRNA (GO:0060964)3.32283875
39regulation of gene silencing by RNA (GO:0060966)3.32283875
40adherens junction assembly (GO:0034333)3.29725970
41DNA replication-dependent nucleosome organization (GO:0034723)3.28735116
42DNA replication-dependent nucleosome assembly (GO:0006335)3.28735116
43positive regulation of chromosome segregation (GO:0051984)3.27637854
44regulation of nucleobase-containing compound transport (GO:0032239)3.24442127
45gene silencing by RNA (GO:0031047)3.24007756
46regulation of spindle organization (GO:0090224)3.23546755
47positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.20517664
48chromosome condensation (GO:0030261)3.18709077
49positive regulation of mitotic sister chromatid separation (GO:1901970)3.18386165
50positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.18386165
51positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.18386165
52negative regulation of RNA splicing (GO:0033119)3.17814555
53regulation of mitotic spindle organization (GO:0060236)3.17573114
54spliceosomal tri-snRNP complex assembly (GO:0000244)3.17335648
55peptidyl-lysine dimethylation (GO:0018027)3.17159260
56positive regulation of extracellular matrix organization (GO:1903055)3.15461641
57histone H4-K12 acetylation (GO:0043983)3.15369784
58regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.14775593
59nuclear envelope organization (GO:0006998)3.08398790
60DNA conformation change (GO:0071103)3.08241534
61COPI coating of Golgi vesicle (GO:0048205)3.08213279
62Golgi transport vesicle coating (GO:0048200)3.08213279
63negative regulation of mRNA processing (GO:0050686)3.08048294
64gene silencing (GO:0016458)3.05669303
65protein localization to chromosome (GO:0034502)3.02819690
66cellular response to epidermal growth factor stimulus (GO:0071364)3.02655657
67negative regulation of histone modification (GO:0031057)3.02068214
68histone H2A monoubiquitination (GO:0035518)3.00595863
69negative regulation of mRNA metabolic process (GO:1903312)2.99770484
70NLS-bearing protein import into nucleus (GO:0006607)2.97996665
71response to laminar fluid shear stress (GO:0034616)2.97939195
72cytoplasmic mRNA processing body assembly (GO:0033962)2.95739223
73cell-substrate junction assembly (GO:0007044)2.95600566
74apoptotic process involved in morphogenesis (GO:0060561)2.92216463
75mitotic metaphase plate congression (GO:0007080)2.91491853
76histone H3-K9 demethylation (GO:0033169)2.91339947
77chromatin assembly or disassembly (GO:0006333)2.90839158
78basement membrane organization (GO:0071711)2.90544151
79folic acid-containing compound biosynthetic process (GO:0009396)2.89659607
80DNA packaging (GO:0006323)2.88649502
81meiotic chromosome segregation (GO:0045132)2.88641629
82activation of Rac GTPase activity (GO:0032863)2.87296137
83regulation of chromosome segregation (GO:0051983)2.85821413
84negative regulation of DNA repair (GO:0045738)2.85334129
85mannose metabolic process (GO:0006013)2.84571504
86negative regulation of chromatin modification (GO:1903309)2.83599832
87response to epidermal growth factor (GO:0070849)2.83542538
88chromatin silencing (GO:0006342)2.82808073
89glucocorticoid receptor signaling pathway (GO:0042921)2.82088269
90DNA replication initiation (GO:0006270)2.79958972
91translesion synthesis (GO:0019985)2.79295777
92regulation of mammary gland epithelial cell proliferation (GO:0033599)2.78502296
93regulation of mRNA stability (GO:0043488)2.76831826
94regulation of translational termination (GO:0006449)2.76199808
95histone lysine demethylation (GO:0070076)2.75684583
96DNA topological change (GO:0006265)2.74392883
97alternative mRNA splicing, via spliceosome (GO:0000380)2.73886157
98regulation of telomere maintenance via telomerase (GO:0032210)2.73334832
99histone H3-K9 methylation (GO:0051567)2.72104646
100DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.71752583
101kinetochore organization (GO:0051383)2.71675371
102attachment of spindle microtubules to kinetochore (GO:0008608)2.70949874
103stress granule assembly (GO:0034063)2.70868031
104metaphase plate congression (GO:0051310)2.70759381
105positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.70468891
106regulation of cholesterol homeostasis (GO:2000188)2.69685174
107histone H4-K5 acetylation (GO:0043981)2.69364218
108histone H4-K8 acetylation (GO:0043982)2.69364218
1093-UTR-mediated mRNA stabilization (GO:0070935)2.69197390
110negative regulation of gene expression, epigenetic (GO:0045814)2.68575858
111nucleosome disassembly (GO:0006337)2.68042093
112protein-DNA complex disassembly (GO:0032986)2.68042093
113mRNA transport (GO:0051028)2.67866667
114IMP biosynthetic process (GO:0006188)2.67859070
115regulation of glucose import in response to insulin stimulus (GO:2001273)2.66237895
116regulation of DNA damage checkpoint (GO:2000001)2.65444489
117histone demethylation (GO:0016577)2.64956073
118positive regulation of gene expression, epigenetic (GO:0045815)2.64788043
119nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.64529653
120positive regulation of blood vessel endothelial cell migration (GO:0043536)2.64414368
121histone H4-K16 acetylation (GO:0043984)2.63805509
122positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.62852129
123negative regulation of fibrinolysis (GO:0051918)2.61989842
124negative regulation of chromosome segregation (GO:0051985)2.61583928
125regulation of RNA stability (GO:0043487)2.60716336
126histone H3-K4 trimethylation (GO:0080182)2.60669460
127positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.60666603
128regulation of extracellular matrix organization (GO:1903053)2.60593849
129corticosteroid receptor signaling pathway (GO:0031958)2.59735274
130histone mRNA catabolic process (GO:0071044)2.59353696
131chromosome segregation (GO:0007059)2.58395445
132planar cell polarity pathway involved in neural tube closure (GO:0090179)2.57732948
133intracellular estrogen receptor signaling pathway (GO:0030520)2.57449037
134thymic T cell selection (GO:0045061)2.57154779
135regulation of early endosome to late endosome transport (GO:2000641)2.56803251
136mitotic G1 DNA damage checkpoint (GO:0031571)2.56662427
137regulation of gene silencing (GO:0060968)2.55931898
138regulation of histone H3-K4 methylation (GO:0051569)2.55490586
139activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.55467652
140skin morphogenesis (GO:0043589)2.53909590
141positive regulation of nuclease activity (GO:0032075)2.51999575
142histone H3-K4 methylation (GO:0051568)2.50990263
143maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.49821961
144protein export from nucleus (GO:0006611)2.47622281
145insulin-like growth factor receptor signaling pathway (GO:0048009)2.46942788
146regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.46229391
147protein-lipid complex assembly (GO:0065005)2.46028542
148cytoskeletal anchoring at plasma membrane (GO:0007016)2.43986775
149protein localization to endosome (GO:0036010)2.42670969
150pinocytosis (GO:0006907)2.42243386
151plasma lipoprotein particle assembly (GO:0034377)2.40411995
152regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.40171205
153regulation of extracellular matrix disassembly (GO:0010715)2.40012928
154modulation by symbiont of host cellular process (GO:0044068)2.39849634
155negative regulation of anoikis (GO:2000811)2.34899553
156regulation of ARF GTPase activity (GO:0032312)2.34377638
157protein dealkylation (GO:0008214)2.32698830
158protein demethylation (GO:0006482)2.32698830
159hypotonic response (GO:0006971)2.31235546
160negative regulation of myotube differentiation (GO:0010832)2.31069033
161retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.29340250
162atrioventricular valve morphogenesis (GO:0003181)2.28952649
163peptidyl-threonine phosphorylation (GO:0018107)2.28369815
164embryonic camera-type eye morphogenesis (GO:0048596)2.28321174
165establishment of spindle orientation (GO:0051294)2.28221441
166regulation of nuclease activity (GO:0032069)2.27821251
167embryonic eye morphogenesis (GO:0048048)2.27734685
168establishment of spindle localization (GO:0051293)2.27315614
169protein retention in ER lumen (GO:0006621)2.25317733
170regulation of anoikis (GO:2000209)2.25129273
171regulation of chromatin binding (GO:0035561)2.23172847
172low-density lipoprotein particle clearance (GO:0034383)2.22999609
173histone H3-K9 modification (GO:0061647)2.21039797
174peptidyl-threonine modification (GO:0018210)2.20801307
175positive regulation of histone deacetylation (GO:0031065)2.20395874
176modulation by virus of host process (GO:0019054)2.20327268

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.22426358
2* FOXM1_23109430_ChIP-Seq_U2OS_Human5.93176840
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.04453487
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.48436684
5MYC_22102868_ChIP-Seq_BL_Human3.44890290
6* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.06268298
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.96762901
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.89315540
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.55641340
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.33884340
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.32326503
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.26581447
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.23603415
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.21783575
15VDR_21846776_ChIP-Seq_THP-1_Human2.09610434
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.08029430
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.07815749
18TCF7_22412390_ChIP-Seq_EML_Mouse2.07456775
19LXR_22292898_ChIP-Seq_THP-1_Human2.00723968
20* E2F1_21310950_ChIP-Seq_MCF-7_Human1.98768262
21ZNF263_19887448_ChIP-Seq_K562_Human1.89763658
22CLOCK_20551151_ChIP-Seq_293T_Human1.87180948
23SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.84917042
24RACK7_27058665_Chip-Seq_MCF-7_Human1.84606852
25AR_21909140_ChIP-Seq_LNCAP_Human1.83987980
26* CIITA_25753668_ChIP-Seq_RAJI_Human1.83161033
27KDM2B_26808549_Chip-Seq_K562_Human1.77277968
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.76533435
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.75981533
30KDM2B_26808549_Chip-Seq_DND41_Human1.72742943
31* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.67847794
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66720363
33* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63652385
34* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.62889458
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62103247
36* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.59705606
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.57610793
38KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.54763611
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53885913
40UTX_26944678_Chip-Seq_JUKART_Human1.53856418
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51925040
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49243614
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.49047652
44* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48654579
45XRN2_22483619_ChIP-Seq_HELA_Human1.46725220
46* MAF_26560356_Chip-Seq_TH1_Human1.46143873
47* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44188901
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42247394
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39961954
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39508274
51* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39492342
52KDM5A_27292631_Chip-Seq_BREAST_Human1.38280081
53* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.34632902
54STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.33310922
55* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.32996767
56UBF1/2_26484160_Chip-Seq_HMECs_Human1.32014985
57KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.31284057
58KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.31284057
59KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.31284057
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29915348
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29193474
62* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.29103355
63SCL_19346495_ChIP-Seq_HPC-7_Human1.28285786
64* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27669229
65* ELK3_25401928_ChIP-Seq_HUVEC_Human1.26834579
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26728170
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26042333
68* MYB_26560356_Chip-Seq_TH1_Human1.25398713
69* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25179240
70MYB_26560356_Chip-Seq_TH2_Human1.24887960
71NANOG_21062744_ChIP-ChIP_HESCs_Human1.24306642
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24094670
73TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23354536
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23075057
75ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22375791
76TP53_22127205_ChIP-Seq_IMR90_Human1.21345082
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21219674
78NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20569026
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18021778
80ESR2_21235772_ChIP-Seq_MCF-7_Human1.16385343
81PKCTHETA_26484144_Chip-Seq_BREAST_Human1.15591013
82NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15533168
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15431833
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15147499
85MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14952061
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14649273
87NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14214841
88RUNX1_27514584_Chip-Seq_MCF-7_Human1.13896207
89* CREB1_26743006_Chip-Seq_LNCaP_Human1.13649738
90FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13121663
91* NCOR1_26117541_ChIP-Seq_K562_Human1.12862432
92ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12475049
93ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.10303831
94SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10248979
95BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10167857
96* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10029908
97CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10023770
98EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09690790
99* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.09433892
100KDM2B_26808549_Chip-Seq_JURKAT_Human1.08406495
101* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07538005
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06875257
103* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06537930
104* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06321121
105* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05886597
106ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05556258
107* SMC4_20622854_ChIP-Seq_HELA_Human1.05474298
108HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05394876
109DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05081362
110SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04827189
111TFEB_21752829_ChIP-Seq_HELA_Human1.04539916
112* FOXA2_19822575_ChIP-Seq_HepG2_Human1.04109356
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03985559
114* FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03972261
115VDR_24763502_ChIP-Seq_THP-1_Human1.03895510
116CHD1_26751641_Chip-Seq_LNCaP_Human1.03707408
117CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03482043
118* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02305064
119TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02293062
120* RUNX1_22412390_ChIP-Seq_EML_Mouse1.02261921
121NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01945013
122HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00652970
123SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99817380
124* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99755066
125MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99220326
126NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98310138
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97550341
128TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97500829
129HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97413615
130MAF_26560356_Chip-Seq_TH2_Human0.96420046
131P68_20966046_ChIP-Seq_HELA_Human0.96403155
132* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95491134
133ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95397228
134ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95368217
135GATA1_19941826_ChIP-Seq_K562_Human0.93763687
136RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93722624
137P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93465146
138* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93261652
139E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92903548
140FOXP3_21729870_ChIP-Seq_TREG_Human0.92239517
141TTF2_22483619_ChIP-Seq_HELA_Human0.92205773
142* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.91328684
143ATF3_27146783_Chip-Seq_COLON_Human0.91134531
144RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90225296
145* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.89180510
146SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88936535
147PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88555407
148E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88299872

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.28160714
2MP0010094_abnormal_chromosome_stability3.18002649
3MP0008057_abnormal_DNA_replication3.15589712
4MP0003077_abnormal_cell_cycle2.98253463
5MP0010352_gastrointestinal_tract_polyps2.95126331
6MP0004957_abnormal_blastocyst_morpholog2.76315035
7MP0003693_abnormal_embryo_hatching2.70324771
8MP0005076_abnormal_cell_differentiation2.63629028
9MP0008438_abnormal_cutaneous_collagen2.59752256
10MP0005409_darkened_coat_color2.52511596
11MP0005451_abnormal_body_composition2.44950876
12MP0009278_abnormal_bone_marrow2.44268788
13MP0008877_abnormal_DNA_methylation2.38473266
14MP0010307_abnormal_tumor_latency2.37956950
15MP0003705_abnormal_hypodermis_morpholog2.30193597
16MP0002396_abnormal_hematopoietic_system2.28878008
17MP0001730_embryonic_growth_arrest2.27668675
18MP0002877_abnormal_melanocyte_morpholog2.26881657
19MP0000350_abnormal_cell_proliferation2.17141958
20MP0004808_abnormal_hematopoietic_stem2.15938354
21MP0001348_abnormal_lacrimal_gland2.10298555
22MP0003123_paternal_imprinting2.08786274
23MP0002009_preneoplasia2.05356549
24MP0008007_abnormal_cellular_replicative2.04409038
25MP0000569_abnormal_digit_pigmentation1.97053799
26MP0005380_embryogenesis_phenotype1.93752847
27MP0001672_abnormal_embryogenesis/_devel1.93752847
28MP0002084_abnormal_developmental_patter1.88318346
29MP0004197_abnormal_fetal_growth/weight/1.85492943
30MP0003984_embryonic_growth_retardation1.81530250
31MP0002088_abnormal_embryonic_growth/wei1.80954570
32MP0008058_abnormal_DNA_repair1.76913407
33MP0002085_abnormal_embryonic_tissue1.76727596
34MP0002086_abnormal_extraembryonic_tissu1.76326719
35MP0001697_abnormal_embryo_size1.75583481
36MP0001545_abnormal_hematopoietic_system1.70710044
37MP0005397_hematopoietic_system_phenotyp1.70710044
38MP0003121_genomic_imprinting1.65770855
39MP0001849_ear_inflammation1.59946696
40MP0000003_abnormal_adipose_tissue1.55837524
41MP0003567_abnormal_fetal_cardiomyocyte1.54679608
42MP0003453_abnormal_keratinocyte_physiol1.54497509
43MP0002080_prenatal_lethality1.52600491
44MP0005257_abnormal_intraocular_pressure1.52138745
45MP0002089_abnormal_postnatal_growth/wei1.51513522
46MP0003763_abnormal_thymus_physiology1.51008644
47MP0004272_abnormal_basement_membrane1.46874961
48MP0000733_abnormal_muscle_development1.46173938
49* MP0000703_abnormal_thymus_morphology1.44653299
50MP0005058_abnormal_lysosome_morphology1.42290008
51MP0003890_abnormal_embryonic-extraembry1.41996368
52MP0000490_abnormal_crypts_of1.38502704
53MP0005666_abnormal_adipose_tissue1.37748967
54MP0003300_gastrointestinal_ulcer1.37327875
55MP0003566_abnormal_cell_adhesion1.31531406
56MP0003303_peritoneal_inflammation1.29892907
57MP0010368_abnormal_lymphatic_system1.29381627
58MP0008932_abnormal_embryonic_tissue1.28673578
59MP0001915_intracranial_hemorrhage1.28659293
60* MP0002398_abnormal_bone_marrow1.28632162
61MP0005375_adipose_tissue_phenotype1.27919307
62MP0003172_abnormal_lysosome_physiology1.27489450
63MP0000537_abnormal_urethra_morphology1.27040082
64MP0002249_abnormal_larynx_morphology1.25690112
65MP0000767_abnormal_smooth_muscle1.25600110
66MP0005023_abnormal_wound_healing1.21788324
67MP0002019_abnormal_tumor_incidence1.21672099
68MP0000313_abnormal_cell_death1.20031108
69MP0001661_extended_life_span1.17907882
70MP0002210_abnormal_sex_determination1.17729916
71MP0002925_abnormal_cardiovascular_devel1.16287327
72MP0003787_abnormal_imprinting1.15960517
73MP0003436_decreased_susceptibility_to1.15447079
74MP0001293_anophthalmia1.14054903
75MP0001929_abnormal_gametogenesis1.12669927
76MP0009053_abnormal_anal_canal1.12078512
77MP0003950_abnormal_plasma_membrane1.11037867
78MP0009703_decreased_birth_body1.10785637
79MP0004947_skin_inflammation1.09545852
80MP0001145_abnormal_male_reproductive1.09415207
81MP0004858_abnormal_nervous_system1.08930463
82MP0000566_synostosis1.08507859
83MP0002653_abnormal_ependyma_morphology1.07765429
84MP0002166_altered_tumor_susceptibility1.06711356
85* MP0002722_abnormal_immune_system1.06693245
86MP0003786_premature_aging1.05203666
87MP0009672_abnormal_birth_weight1.05192539
88MP0008961_abnormal_basal_metabolism1.03635968
89MP0010234_abnormal_vibrissa_follicle1.03048744
90MP0003119_abnormal_digestive_system1.02673780
91MP0003115_abnormal_respiratory_system1.02650218
92MP0002060_abnormal_skin_morphology1.02555615
93MP0003385_abnormal_body_wall1.02200481
94* MP0000689_abnormal_spleen_morphology1.01101832
95MP0003279_aneurysm1.00797584
96MP0000428_abnormal_craniofacial_morphol0.99075795
97MP0003942_abnormal_urinary_system0.98936636
98MP0005360_urolithiasis0.98666917
99MP0002933_joint_inflammation0.98311119
100MP0008260_abnormal_autophagy0.98217599
101MP0004185_abnormal_adipocyte_glucose0.97376538
102MP0003935_abnormal_craniofacial_develop0.96797021
103MP0005623_abnormal_meninges_morphology0.96646958
104MP0009840_abnormal_foam_cell0.94275062
105MP0010030_abnormal_orbit_morphology0.93802315
106MP0002092_abnormal_eye_morphology0.93703949
107MP0009333_abnormal_splenocyte_physiolog0.93561859
108MP0000534_abnormal_ureter_morphology0.92638108
109MP0008995_early_reproductive_senescence0.92222493
110MP0001958_emphysema0.90662908
111MP0006138_congestive_heart_failure0.90140078
112MP0010630_abnormal_cardiac_muscle0.90137925
113MP0002697_abnormal_eye_size0.88114319
114MP0000653_abnormal_sex_gland0.86794817
115MP0001270_distended_abdomen0.85381505
116MP0000678_abnormal_parathyroid_gland0.84554830
117* MP0002429_abnormal_blood_cell0.84202717
118MP0000266_abnormal_heart_morphology0.84165547
119MP0001800_abnormal_humoral_immune0.84082887
120MP0008770_decreased_survivor_rate0.83895212
121MP0004264_abnormal_extraembryonic_tissu0.82888771
122MP0006054_spinal_hemorrhage0.82875627
123MP0005621_abnormal_cell_physiology0.81932588
124MP0000432_abnormal_head_morphology0.81629962
125MP0003091_abnormal_cell_migration0.80314746
126MP0000759_abnormal_skeletal_muscle0.80086617
127MP0001346_abnormal_lacrimal_gland0.79487506
128* MP0000716_abnormal_immune_system0.79436523
129MP0004381_abnormal_hair_follicle0.79307252
130MP0000685_abnormal_immune_system0.78766778
131MP0004087_abnormal_muscle_fiber0.78511086
132MP0003943_abnormal_hepatobiliary_system0.78048026
133MP0001614_abnormal_blood_vessel0.77872203
134MP0003861_abnormal_nervous_system0.77357015
135MP0003315_abnormal_perineum_morphology0.76752314
136MP0002006_tumorigenesis0.75684080
137MP0002405_respiratory_system_inflammati0.74606504
138MP0003191_abnormal_cellular_cholesterol0.74049302
139MP0001873_stomach_inflammation0.73757894
140MP0004233_abnormal_muscle_weight0.73237735
141MP0001216_abnormal_epidermal_layer0.72333540
142MP0001879_abnormal_lymphatic_vessel0.72294077
143MP0002932_abnormal_joint_morphology0.72084395
144MP0005384_cellular_phenotype0.70615684
145MP0003698_abnormal_male_reproductive0.70465553
146MP0000477_abnormal_intestine_morphology0.69864280
147MP0000858_altered_metastatic_potential0.69711036

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.54147007
2Short 4th metacarpal (HP:0010044)3.49345741
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.49345741
4Ependymoma (HP:0002888)3.43255095
5Broad face (HP:0000283)3.29175541
6Deep venous thrombosis (HP:0002625)3.21543540
7Abnormality of the fingertips (HP:0001211)3.19349659
8Flat acetabular roof (HP:0003180)3.11677687
9Volvulus (HP:0002580)2.98623777
10Premature rupture of membranes (HP:0001788)2.94471919
11Hyperacusis (HP:0010780)2.89862769
12Astrocytoma (HP:0009592)2.86350282
13Abnormality of the astrocytes (HP:0100707)2.86350282
14Increased nuchal translucency (HP:0010880)2.75937143
15Abnormality of the 4th metacarpal (HP:0010012)2.71145265
16Medulloblastoma (HP:0002885)2.66242642
17Disproportionate tall stature (HP:0001519)2.58334585
18Long eyelashes (HP:0000527)2.56988715
19Neoplasm of the oral cavity (HP:0100649)2.53446086
20Basal cell carcinoma (HP:0002671)2.50929530
21Selective tooth agenesis (HP:0001592)2.49408260
22Arterial tortuosity (HP:0005116)2.47020970
23Proximal placement of thumb (HP:0009623)2.47004565
24Asymmetry of the thorax (HP:0001555)2.45729609
25Deviation of the thumb (HP:0009603)2.45211030
26Obstructive sleep apnea (HP:0002870)2.44702912
27Macroorchidism (HP:0000053)2.44181698
28Prominent nose (HP:0000448)2.43020440
29Neoplasm of striated muscle (HP:0009728)2.34242160
30Renal duplication (HP:0000075)2.31947247
31Cerebral aneurysm (HP:0004944)2.28660221
32Spinal cord lesions (HP:0100561)2.27326888
33Syringomyelia (HP:0003396)2.27326888
34Supernumerary ribs (HP:0005815)2.27157077
35Vascular tortuosity (HP:0004948)2.26727940
36* Heterotopia (HP:0002282)2.26465886
37Abnormality of the lower motor neuron (HP:0002366)2.26413033
38Abnormal ossification of hand bones (HP:0005921)2.24891433
39Pseudobulbar signs (HP:0002200)2.23867079
40Ankyloglossia (HP:0010296)2.23348562
41High pitched voice (HP:0001620)2.22836735
42Rhabdomyosarcoma (HP:0002859)2.22172125
43Colon cancer (HP:0003003)2.21231856
44Cervical subluxation (HP:0003308)2.20680926
45Abnormality of carpal bone ossification (HP:0006257)2.18625117
46Skull defect (HP:0001362)2.16878850
47* Dislocated radial head (HP:0003083)2.15442768
48Shallow orbits (HP:0000586)2.13902388
49Glioma (HP:0009733)2.11670848
50Mitral regurgitation (HP:0001653)2.10438389
5111 pairs of ribs (HP:0000878)2.09351813
52Aneurysm (HP:0002617)2.09236627
53Ectopic kidney (HP:0000086)2.08844307
54Urethral obstruction (HP:0000796)2.07212253
55Skin tags (HP:0010609)2.07024588
56Gastrointestinal carcinoma (HP:0002672)2.05734979
57Malignant gastrointestinal tract tumors (HP:0006749)2.05734979
58Vertebral compression fractures (HP:0002953)2.05459716
59Renovascular hypertension (HP:0100817)2.04494356
60Supernumerary bones of the axial skeleton (HP:0009144)2.03816325
61Abnormal foot bone ossification (HP:0010675)2.03795949
62Abnormality of oral frenula (HP:0000190)2.02406711
63Thin bony cortex (HP:0002753)2.01236216
64Short nail (HP:0001799)2.00304441
65Aortic dissection (HP:0002647)2.00135873
66Biconcave vertebral bodies (HP:0004586)1.99839200
67Increased density of long bones (HP:0006392)1.99769434
68Hemorrhage of the eye (HP:0011885)1.99708388
69Small epiphyses (HP:0010585)1.99203590
70Rib fusion (HP:0000902)1.98879033
71Cupped ribs (HP:0000887)1.98663165
72Sandal gap (HP:0001852)1.98618339
73Broad thumb (HP:0011304)1.96984432
74Impulsivity (HP:0100710)1.95075485
75Limited elbow extension (HP:0001377)1.93757157
76* Abnormality of the radial head (HP:0003995)1.93092154
77Chromsome breakage (HP:0040012)1.92505991
78Dilatation of the ascending aorta (HP:0005111)1.92485408
79Vertebral arch anomaly (HP:0008438)1.92010727
80Long palpebral fissure (HP:0000637)1.91937136
81Abnormality of the acetabulum (HP:0003170)1.90650257
82* Broad palm (HP:0001169)1.90490939
83Cafe-au-lait spot (HP:0000957)1.90280423
84Ulnar bowing (HP:0003031)1.89898878
85Abnormality of the phalanges of the hallux (HP:0010057)1.88735697
86Abnormality of the calcaneus (HP:0008364)1.88431304
87Cutis marmorata (HP:0000965)1.88169446
88Abnormality of the labia minora (HP:0012880)1.87412668
89Distal lower limb amyotrophy (HP:0008944)1.87210591
90Thin ribs (HP:0000883)1.87183209
91Missing ribs (HP:0000921)1.86635216
92Elfin facies (HP:0004428)1.85297311
93Wormian bones (HP:0002645)1.84089341
94Dysmetric saccades (HP:0000641)1.83381013
95Bicuspid aortic valve (HP:0001647)1.83247349
96Joint laxity (HP:0001388)1.82669408
97Abnormal tarsal ossification (HP:0008369)1.82315035
98Patellar aplasia (HP:0006443)1.82056144
99Truncal obesity (HP:0001956)1.80826769
100Bowel diverticulosis (HP:0005222)1.80104511
101Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.80061842
102Nasal polyposis (HP:0100582)1.79912835
103Ankle contracture (HP:0006466)1.79027283
104Obsessive-compulsive behavior (HP:0000722)1.78670766
105Short phalanx of the thumb (HP:0009660)1.78580406
106Genu recurvatum (HP:0002816)1.78367304
107Broad phalanges of the hand (HP:0009768)1.78024943
108Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.78004033
109Absent frontal sinuses (HP:0002688)1.77805036
110Persistence of primary teeth (HP:0006335)1.77396069
111Enlarged penis (HP:0000040)1.77372573
112Insomnia (HP:0100785)1.76771188
113Fragile skin (HP:0001030)1.76762532
114Birth length less than 3rd percentile (HP:0003561)1.76706824
115Abnormality of the thoracic spine (HP:0100711)1.76435695
116Increased connective tissue (HP:0009025)1.75316286
117Bladder diverticulum (HP:0000015)1.75252749
118Neonatal short-limb short stature (HP:0008921)1.74948084
119Anal stenosis (HP:0002025)1.74259338
120Colitis (HP:0002583)1.73409188
121Advanced eruption of teeth (HP:0006288)1.72810623
122Chromosomal breakage induced by crosslinking agents (HP:0003221)1.72451794
123Amaurosis fugax (HP:0100576)1.71540097
124Short humerus (HP:0005792)1.71367558
125Abnormal hand bone ossification (HP:0010660)1.70388300
126Preauricular skin tag (HP:0000384)1.70382178
127Shawl scrotum (HP:0000049)1.69961833
128Overriding aorta (HP:0002623)1.69944692
129Relative macrocephaly (HP:0004482)1.69788145
130Osteolytic defects of the hand bones (HP:0009699)1.69301263
131Osteolytic defects of the phalanges of the hand (HP:0009771)1.69301263
132Sparse lateral eyebrow (HP:0005338)1.69268536
133Abnormality of the peritoneum (HP:0002585)1.69256926
134Metaphyseal cupping (HP:0003021)1.69118315
135Acute myeloid leukemia (HP:0004808)1.69066588
136* Myelodysplasia (HP:0002863)1.68967311
137Pointed chin (HP:0000307)1.68866193
138Achilles tendon contracture (HP:0001771)1.68578925
139Abnormal number of incisors (HP:0011064)1.68455927
140Subacute progressive viral hepatitis (HP:0006572)1.68249617
141Blue sclerae (HP:0000592)1.67675320
142Patellar dislocation (HP:0002999)1.67072633
143Premature skin wrinkling (HP:0100678)1.66598398
144Abnormality of the distal phalanges of the toes (HP:0010182)1.66168670
145Abnormality of the Achilles tendon (HP:0005109)1.65830714
146Biliary tract neoplasm (HP:0100574)1.65810668
147Fatigue (HP:0012378)1.65789244
148Intestinal fistula (HP:0100819)1.65143004
149Fibrous tissue neoplasm (HP:0012316)1.64798321
150Aplasia/Hypoplasia of the patella (HP:0006498)1.64244997
151Aortic aneurysm (HP:0004942)1.63627539
152Mitral valve prolapse (HP:0001634)1.62733462
153Short 1st metacarpal (HP:0010034)1.61177623
154Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.61177623
155Fibroma (HP:0010614)1.60698850
156Coxa vara (HP:0002812)1.60529089
157Aplasia/Hypoplasia of the sternum (HP:0006714)1.60412859
158Natal tooth (HP:0000695)1.59544048
159T lymphocytopenia (HP:0005403)1.59486284
160Atresia of the external auditory canal (HP:0000413)1.58192272
161Aplasia/hypoplasia of the humerus (HP:0006507)1.57669140
162Megalocornea (HP:0000485)1.57241304
163* Low anterior hairline (HP:0000294)1.57066873
164Esophageal atresia (HP:0002032)1.56172329
165Broad finger (HP:0001500)1.55852782
166Abnormality of chromosome segregation (HP:0002916)1.55547058
167Cutaneous melanoma (HP:0012056)1.55108865
168Abnormality of chromosome stability (HP:0003220)1.54023128
169Deep philtrum (HP:0002002)1.53649323
170Abnormality of the nasal septum (HP:0000419)1.53380808
171Segmental peripheral demyelination/remyelination (HP:0003481)1.53375699
172Abnormality of the distal phalanx of the thumb (HP:0009617)1.53076002
173Self-mutilation (HP:0000742)1.52866133
174Arnold-Chiari malformation (HP:0002308)1.52858016
175Abnormality of the common coagulation pathway (HP:0010990)1.52465007
176Atrophic scars (HP:0001075)1.51509776
177Flattened epiphyses (HP:0003071)1.51464133
178Distal upper limb amyotrophy (HP:0007149)1.51156542
179Upper limb amyotrophy (HP:0009129)1.51156542
180Flared metaphyses (HP:0003015)1.51025285

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.15224736
2EEF2K4.06358555
3CDC73.62636279
4MAP3K103.17011104
5PRPF4B2.90079666
6SMG12.77469013
7NEK22.75994866
8PKN22.71742149
9STK102.53277930
10TRIB32.35951913
11ERN12.26205878
12LATS12.06451865
13MAP4K12.01072172
14BRD41.86821376
15IRAK31.70828526
16ICK1.64473542
17CDK41.58029824
18MAP3K131.57943708
19TTK1.55914512
20RPS6KB21.54877367
21WEE11.54140362
22MTOR1.43315671
23CDK71.41365578
24CDK61.36966662
25TYRO31.36764567
26ALK1.36375346
27STK31.35947981
28TTN1.31876662
29MAP3K81.31773339
30ATR1.31732238
31PTK61.31015450
32CDC42BPA1.22805192
33MST1R1.21784641
34CHEK11.21483565
35PAK41.17674833
36MAPK111.15362946
37MARK21.14414692
38KSR21.14166604
39RIPK11.12383919
40MELK1.11197840
41TGFBR11.10931086
42PLK11.10045190
43PASK1.09438118
44NEK11.08751488
45LRRK21.08549945
46PDGFRA1.05515261
47MAP3K141.05068589
48STK41.03390051
49CAMK1D1.01595928
50DDR21.00906900
51MAP2K30.99324223
52CHEK20.99116637
53CDK90.98696638
54PIM10.97520078
55GRK60.95794584
56TSSK60.95633754
57SCYL20.95368119
58ATM0.94508090
59AURKB0.92876980
60JAK30.90940794
61WNK10.89233943
62SIK20.88868222
63CDK20.88390482
64TAOK10.87794687
65TGFBR20.87717572
66FGFR30.84609104
67CAMK1G0.84584977
68MET0.84206502
69LATS20.84070471
70PTK20.83528982
71CDK80.82374268
72RPS6KA40.79959079
73FLT30.79920952
74PAK20.79212483
75EPHB10.77253090
76AKT30.76977354
77PDGFRB0.75331339
78ZAP700.74806689
79SIK30.74011702
80DYRK30.72664565
81NEK90.71985662
82HIPK20.69506666
83SGK30.69230361
84PRKD20.68929224
85MKNK10.68491705
86FGFR40.67007206
87CSF1R0.65289289
88PDPK10.62981037
89CLK10.62508196
90DMPK0.62502813
91FGFR10.62070386
92CDK10.61969035
93MAP3K10.61417573
94PLK30.59525385
95SRPK10.58691042
96MKNK20.55801433
97BMX0.54645816
98MAP3K20.53771116
99MAP3K30.53242511
100ITK0.53143848
101PNCK0.52589208
102CSNK1D0.51641523
103SIK10.51606659
104TAOK20.51357843
105CSK0.50973385
106CHUK0.50719375
107PRKD30.50328473
108TRPM70.48987073
109MAP3K70.48515232
110EPHA20.47392965
111MARK30.46560705
112CAMKK10.46063357
113HCK0.45952274
114MAPK140.45847758
115MAPK100.45742148
116IRAK20.45678966
117BUB10.44988873
118BTK0.44260781
119JAK10.44199603
120NTRK10.44119858
121MAP3K90.43976660
122STK380.43857647
123PRKDC0.43812259
124PDK10.43128886
125DYRK1B0.42673294
126MAP3K60.42358134
127RPS6KA10.41932412
128MAPK10.41928372
129RAF10.40566280
130TYK20.40344114
131RPS6KC10.39999177
132RPS6KL10.39999177
133MOS0.39103752
134RPS6KA20.39071268
135FGFR20.38474540
136AKT10.38426445
137NME20.37846992
138MAPK70.37421496
139CSNK1E0.37063792
140JAK20.36855276
141BRSK10.36790281
142AKT20.36558720
143RET0.35855484
144GSK3B0.35743441
145MAPK120.34664814
146BRAF0.34309885

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.69993438
2RNA transport_Homo sapiens_hsa030132.55656549
3Cell cycle_Homo sapiens_hsa041102.51114767
4Mismatch repair_Homo sapiens_hsa034302.32948050
5Spliceosome_Homo sapiens_hsa030402.30955424
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.23130446
7mRNA surveillance pathway_Homo sapiens_hsa030152.20737956
8One carbon pool by folate_Homo sapiens_hsa006701.79161399
9Base excision repair_Homo sapiens_hsa034101.75631798
10Chronic myeloid leukemia_Homo sapiens_hsa052201.72153756
11Other glycan degradation_Homo sapiens_hsa005111.70810447
12MicroRNAs in cancer_Homo sapiens_hsa052061.64619096
13Notch signaling pathway_Homo sapiens_hsa043301.61258011
14Lysine degradation_Homo sapiens_hsa003101.59554632
15Non-homologous end-joining_Homo sapiens_hsa034501.54597820
16RNA degradation_Homo sapiens_hsa030181.43782184
17Viral carcinogenesis_Homo sapiens_hsa052031.41401805
18Small cell lung cancer_Homo sapiens_hsa052221.40263688
19Fanconi anemia pathway_Homo sapiens_hsa034601.39479523
20Homologous recombination_Homo sapiens_hsa034401.38968494
21mTOR signaling pathway_Homo sapiens_hsa041501.38454653
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.37588573
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36638016
24HTLV-I infection_Homo sapiens_hsa051661.35370071
25Colorectal cancer_Homo sapiens_hsa052101.35204415
26p53 signaling pathway_Homo sapiens_hsa041151.34646676
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34190407
28Nucleotide excision repair_Homo sapiens_hsa034201.30356309
29Prion diseases_Homo sapiens_hsa050201.27438657
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.27010251
31Herpes simplex infection_Homo sapiens_hsa051681.26487131
32Adherens junction_Homo sapiens_hsa045201.26123737
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.24955157
34Antigen processing and presentation_Homo sapiens_hsa046121.22553531
35B cell receptor signaling pathway_Homo sapiens_hsa046621.21191712
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20920106
37Choline metabolism in cancer_Homo sapiens_hsa052311.20601759
38T cell receptor signaling pathway_Homo sapiens_hsa046601.20098614
39Primary immunodeficiency_Homo sapiens_hsa053401.19112308
40Acute myeloid leukemia_Homo sapiens_hsa052211.16671876
41Non-small cell lung cancer_Homo sapiens_hsa052231.15535327
42Oocyte meiosis_Homo sapiens_hsa041141.15276152
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.14362808
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.14341671
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12800733
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.12736106
47ECM-receptor interaction_Homo sapiens_hsa045121.11381150
48Viral myocarditis_Homo sapiens_hsa054161.11072135
49Dorso-ventral axis formation_Homo sapiens_hsa043201.08606412
50Basal cell carcinoma_Homo sapiens_hsa052171.08096594
51Epstein-Barr virus infection_Homo sapiens_hsa051691.08077613
52Pancreatic cancer_Homo sapiens_hsa052121.07929689
53Endometrial cancer_Homo sapiens_hsa052131.05873508
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04633031
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04456639
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04231410
57Hippo signaling pathway_Homo sapiens_hsa043901.04136728
58Thyroid cancer_Homo sapiens_hsa052161.02441344
59Inositol phosphate metabolism_Homo sapiens_hsa005621.00859012
60Phospholipase D signaling pathway_Homo sapiens_hsa040721.00718673
61Proteoglycans in cancer_Homo sapiens_hsa052051.00362090
62Basal transcription factors_Homo sapiens_hsa030221.00022815
63Hepatitis B_Homo sapiens_hsa051610.98615368
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98150942
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.97803541
66TGF-beta signaling pathway_Homo sapiens_hsa043500.94385638
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.94108206
68GnRH signaling pathway_Homo sapiens_hsa049120.93333413
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90499833
70Toxoplasmosis_Homo sapiens_hsa051450.89979372
71VEGF signaling pathway_Homo sapiens_hsa043700.89515133
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.86602923
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.86130149
74Hepatitis C_Homo sapiens_hsa051600.85250591
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.84991831
76Prostate cancer_Homo sapiens_hsa052150.83870221
77Measles_Homo sapiens_hsa051620.82740242
78Complement and coagulation cascades_Homo sapiens_hsa046100.80517734
79Apoptosis_Homo sapiens_hsa042100.80462451
80Pathways in cancer_Homo sapiens_hsa052000.80234464
81Leishmaniasis_Homo sapiens_hsa051400.78722480
82Focal adhesion_Homo sapiens_hsa045100.77647123
83Osteoclast differentiation_Homo sapiens_hsa043800.77271270
84Renal cell carcinoma_Homo sapiens_hsa052110.76407311
85Amoebiasis_Homo sapiens_hsa051460.75942056
86Bladder cancer_Homo sapiens_hsa052190.75788833
87Prolactin signaling pathway_Homo sapiens_hsa049170.74884189
88Systemic lupus erythematosus_Homo sapiens_hsa053220.74518388
89Platelet activation_Homo sapiens_hsa046110.73226415
90FoxO signaling pathway_Homo sapiens_hsa040680.72807326
91Glioma_Homo sapiens_hsa052140.71114904
92Shigellosis_Homo sapiens_hsa051310.70895361
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69339167
94Wnt signaling pathway_Homo sapiens_hsa043100.69217103
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68428385
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68131235
97Influenza A_Homo sapiens_hsa051640.66500352
98HIF-1 signaling pathway_Homo sapiens_hsa040660.66485059
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65495416
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64550585
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.64539479
102Hedgehog signaling pathway_Homo sapiens_hsa043400.63651571
103Estrogen signaling pathway_Homo sapiens_hsa049150.63341796
104Long-term potentiation_Homo sapiens_hsa047200.62125696
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.61489182
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61169857
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60046829
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.59735673
109Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59606075
110N-Glycan biosynthesis_Homo sapiens_hsa005100.57798628
111Insulin resistance_Homo sapiens_hsa049310.56252224
112AMPK signaling pathway_Homo sapiens_hsa041520.54753931
113TNF signaling pathway_Homo sapiens_hsa046680.54676729
114Endocytosis_Homo sapiens_hsa041440.53581959
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.53176178
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52946579
117Melanoma_Homo sapiens_hsa052180.52883872
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52527028
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52009862
120MAPK signaling pathway_Homo sapiens_hsa040100.51855587
121Fatty acid biosynthesis_Homo sapiens_hsa000610.51320252
122Rap1 signaling pathway_Homo sapiens_hsa040150.50283938
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50213790
124Selenocompound metabolism_Homo sapiens_hsa004500.49558407
125Hematopoietic cell lineage_Homo sapiens_hsa046400.48601185
126Ribosome_Homo sapiens_hsa030100.46527225
127Insulin signaling pathway_Homo sapiens_hsa049100.45288763
128Glucagon signaling pathway_Homo sapiens_hsa049220.44614458
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44303628
130ErbB signaling pathway_Homo sapiens_hsa040120.43430452

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »