ASNS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-serine metabolic process (GO:0006563)6.73887015
2folic acid-containing compound biosynthetic process (GO:0009396)4.93646350
3regulation of translational fidelity (GO:0006450)4.71044806
4formation of translation preinitiation complex (GO:0001731)4.63557172
5tRNA aminoacylation for protein translation (GO:0006418)4.61017591
6tRNA aminoacylation (GO:0043039)4.46969076
7amino acid activation (GO:0043038)4.46969076
8serine family amino acid biosynthetic process (GO:0009070)4.46649474
9IMP biosynthetic process (GO:0006188)4.29873179
10cullin deneddylation (GO:0010388)4.29580413
11nucleobase biosynthetic process (GO:0046112)4.21331727
12histone arginine methylation (GO:0034969)4.17946504
13peptidyl-arginine omega-N-methylation (GO:0035247)4.05067424
14DNA replication-dependent nucleosome assembly (GO:0006335)4.00050693
15DNA replication-dependent nucleosome organization (GO:0034723)4.00050693
16DNA replication initiation (GO:0006270)3.87185412
17protein deneddylation (GO:0000338)3.83559908
18nuclear pore organization (GO:0006999)3.82031849
19mitotic sister chromatid segregation (GO:0000070)3.79841612
20purine nucleobase biosynthetic process (GO:0009113)3.78922664
21regulation of translational termination (GO:0006449)3.74158707
22regulation of gene silencing by RNA (GO:0060966)3.72004482
23regulation of posttranscriptional gene silencing (GO:0060147)3.72004482
24regulation of gene silencing by miRNA (GO:0060964)3.72004482
25peptidyl-arginine methylation (GO:0018216)3.58464143
26peptidyl-arginine N-methylation (GO:0035246)3.58464143
27ribosome biogenesis (GO:0042254)3.57237144
28DNA unwinding involved in DNA replication (GO:0006268)3.55313752
29IMP metabolic process (GO:0046040)3.50108833
30protein localization to kinetochore (GO:0034501)3.48604749
31mitotic nuclear envelope disassembly (GO:0007077)3.48335617
32nuclear pore complex assembly (GO:0051292)3.44948609
33somatic hypermutation of immunoglobulin genes (GO:0016446)3.43489714
34somatic diversification of immune receptors via somatic mutation (GO:0002566)3.43489714
35establishment of protein localization to mitochondrial membrane (GO:0090151)3.40554204
36DNA strand elongation involved in DNA replication (GO:0006271)3.35007065
37proline biosynthetic process (GO:0006561)3.34614881
38nuclear envelope disassembly (GO:0051081)3.33957032
39membrane disassembly (GO:0030397)3.33957032
40sister chromatid segregation (GO:0000819)3.29829526
41regulation of translational elongation (GO:0006448)3.29324972
42mitotic sister chromatid cohesion (GO:0007064)3.26035831
43ribosomal large subunit biogenesis (GO:0042273)3.24345998
44regulation of centriole replication (GO:0046599)3.23349769
45DNA replication checkpoint (GO:0000076)3.22094879
46ribosome assembly (GO:0042255)3.21893878
47mitotic metaphase plate congression (GO:0007080)3.21149415
48regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.18298156
49DNA strand elongation (GO:0022616)3.17014700
50chaperone-mediated protein complex assembly (GO:0051131)3.13683581
51CENP-A containing nucleosome assembly (GO:0034080)3.11636643
52Golgi transport vesicle coating (GO:0048200)3.10837350
53COPI coating of Golgi vesicle (GO:0048205)3.10837350
54L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.10681138
55oxaloacetate metabolic process (GO:0006107)3.08024486
56mitotic chromosome condensation (GO:0007076)3.05870335
57regulation of translation in response to stress (GO:0043555)3.05441301
58DNA double-strand break processing (GO:0000729)3.01230545
59maturation of SSU-rRNA (GO:0030490)2.99372059
60DNA topological change (GO:0006265)2.98379086
61pteridine-containing compound biosynthetic process (GO:0042559)2.97768941
62establishment of integrated proviral latency (GO:0075713)2.97761261
63tetrahydrofolate metabolic process (GO:0046653)2.96419234
64establishment of viral latency (GO:0019043)2.95647762
65pre-miRNA processing (GO:0031054)2.93502347
66de novo protein folding (GO:0006458)2.88568761
67postreplication repair (GO:0006301)2.87712683
68ribonucleoprotein complex biogenesis (GO:0022613)2.86279054
69telomere maintenance via semi-conservative replication (GO:0032201)2.86153042
70determination of adult lifespan (GO:0008340)2.81754035
71non-recombinational repair (GO:0000726)2.81169671
72double-strand break repair via nonhomologous end joining (GO:0006303)2.81169671
73NADH metabolic process (GO:0006734)2.78427698
74regulation of helicase activity (GO:0051095)2.78077782
75anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.77988545
76DNA geometric change (GO:0032392)2.77484078
77DNA duplex unwinding (GO:0032508)2.77198924
78telomere maintenance via recombination (GO:0000722)2.76942247
79de novo posttranslational protein folding (GO:0051084)2.75962239
80folic acid-containing compound metabolic process (GO:0006760)2.75676667
81DNA replication-independent nucleosome assembly (GO:0006336)2.75390401
82DNA replication-independent nucleosome organization (GO:0034724)2.75390401
83mitochondrial DNA metabolic process (GO:0032042)2.75316325
84homocysteine metabolic process (GO:0050667)2.74817214
85G1/S transition of mitotic cell cycle (GO:0000082)2.74796587
86cell cycle G1/S phase transition (GO:0044843)2.74796587
87mitotic recombination (GO:0006312)2.74788167
88negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.74282403
89protein complex localization (GO:0031503)2.73470605
90heterochromatin organization (GO:0070828)2.70482411
91histone exchange (GO:0043486)2.70125007
92protein K6-linked ubiquitination (GO:0085020)2.69752286
93positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.69608326
94regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.67909228
95regulation of centrosome cycle (GO:0046605)2.67090054
96regulation of translational initiation (GO:0006446)2.64711076
97translational initiation (GO:0006413)2.63911055
98spindle checkpoint (GO:0031577)2.63138321
99negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.62698390
100negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.62698390
101negative regulation of mitotic sister chromatid segregation (GO:0033048)2.62698390
102negative regulation of mitotic sister chromatid separation (GO:2000816)2.62698390
103negative regulation of sister chromatid segregation (GO:0033046)2.62698390
104pteridine-containing compound metabolic process (GO:0042558)2.62608845
105protein localization to chromosome, centromeric region (GO:0071459)2.62506618
106spliceosomal snRNP assembly (GO:0000387)2.61854460
107maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.61784447
108ribosomal small subunit biogenesis (GO:0042274)2.61557477
109metaphase plate congression (GO:0051310)2.60764068
110regulation of chromosome segregation (GO:0051983)2.60424907
111mitotic spindle checkpoint (GO:0071174)2.60387881
112negative regulation of translational initiation (GO:0045947)2.59229564
113telomere maintenance via telomere lengthening (GO:0010833)2.59120007
114anterior/posterior axis specification, embryo (GO:0008595)2.58477465
115negative regulation of DNA recombination (GO:0045910)2.58287232
116nucleotide-excision repair, DNA gap filling (GO:0006297)2.58053616
117protein retention in ER lumen (GO:0006621)2.57417155
118ribosomal small subunit assembly (GO:0000028)2.56390172
119telomere maintenance via telomerase (GO:0007004)2.55687088
120DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.55620053
121pore complex assembly (GO:0046931)2.54431784
122signal transduction involved in DNA damage checkpoint (GO:0072422)2.54333164
123signal transduction involved in DNA integrity checkpoint (GO:0072401)2.54333164
124kinetochore organization (GO:0051383)2.53937267
125cellular protein complex localization (GO:0034629)2.53923875
126DNA strand renaturation (GO:0000733)2.53905131
127positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.53197854
128intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.53129633
129signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.53129633
130negative regulation of ligase activity (GO:0051352)2.52834831
131negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.52834831
132chromatin remodeling at centromere (GO:0031055)2.52582836
133negative regulation of chromosome segregation (GO:0051985)2.52086894
134maturation of 5.8S rRNA (GO:0000460)2.52041660
135chromosome segregation (GO:0007059)2.51780469
136tRNA metabolic process (GO:0006399)2.50955093
137pseudouridine synthesis (GO:0001522)2.50443767
138protein maturation by protein folding (GO:0022417)2.50138286
139regulation of DNA endoreduplication (GO:0032875)2.50085131
140signal transduction involved in cell cycle checkpoint (GO:0072395)2.49949888
141spliceosomal tri-snRNP complex assembly (GO:0000244)2.49526733
142signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.49024557
143signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.49024557
144mitotic spindle assembly checkpoint (GO:0007094)2.47852839
145regulation of mitotic spindle organization (GO:0060236)2.47248747
146spindle assembly checkpoint (GO:0071173)2.46251285
147rRNA processing (GO:0006364)2.46103082
148protein localization to chromosome (GO:0034502)2.44897823
149meiotic chromosome segregation (GO:0045132)2.44018369
150RNA-dependent DNA replication (GO:0006278)2.43809293
151ribonucleoprotein complex disassembly (GO:0032988)2.43440258
152regulation of mitotic metaphase/anaphase transition (GO:0030071)2.43393005
153regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.43393005
154regulation of mitotic sister chromatid segregation (GO:0033047)2.43113608

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.36053738
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.43769924
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.55364543
4MYC_19079543_ChIP-ChIP_MESCs_Mouse3.42449089
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11041962
6* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.94791249
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.90655501
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.82073650
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.78872890
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.75492220
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.68850069
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.66670871
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.63158301
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.62530661
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.57886070
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.52727387
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.51110923
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.45582550
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42612702
20POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.38885569
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.37030303
22* NANOG_18555785_ChIP-Seq_MESCs_Mouse2.32474262
23SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.31528915
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.21363490
25* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.21277804
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.17371862
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.15778033
28NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.15399771
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.15077609
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.15077609
31KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.15077609
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14682604
33MYCN_18555785_ChIP-Seq_MESCs_Mouse2.08571095
34XRN2_22483619_ChIP-Seq_HELA_Human2.05309538
35POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.04595057
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95023693
37DCP1A_22483619_ChIP-Seq_HELA_Human1.89970374
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.88785582
39ESR1_15608294_ChIP-ChIP_MCF-7_Human1.83893538
40VDR_23849224_ChIP-Seq_CD4+_Human1.83553205
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.83065290
42SOX2_18555785_ChIP-Seq_MESCs_Mouse1.79406575
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79132022
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78682235
45PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.78063508
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76892305
47* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.76199037
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74915627
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73653414
50GABP_19822575_ChIP-Seq_HepG2_Human1.73004627
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.72033232
52TTF2_22483619_ChIP-Seq_HELA_Human1.70885742
53SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.70284016
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.62874739
55* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.62500932
56ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.60345478
57FOXP3_21729870_ChIP-Seq_TREG_Human1.57509807
58AR_21909140_ChIP-Seq_LNCAP_Human1.57439720
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55603197
60* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55404070
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.52865789
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52820566
63ELK1_19687146_ChIP-ChIP_HELA_Human1.50361823
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.49283787
65* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.46674512
66* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.45132552
67* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.40719515
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39733346
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36150548
70* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.34520604
71TFEB_21752829_ChIP-Seq_HELA_Human1.34205704
72MYC_18940864_ChIP-ChIP_HL60_Human1.33547529
73NANOG_21062744_ChIP-ChIP_HESCs_Human1.33413754
74* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32404578
75KDM5A_27292631_Chip-Seq_BREAST_Human1.31436490
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30059703
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.28883635
78E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26864962
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25591136
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25507127
81SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24539870
82* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21523227
83EGR1_19374776_ChIP-ChIP_THP-1_Human1.20862263
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19912934
85* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.18098995
86OCT4_18692474_ChIP-Seq_MEFs_Mouse1.17013155
87* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.14653221
88SOX2_16153702_ChIP-ChIP_HESCs_Human1.11258565
89SRF_21415370_ChIP-Seq_HL-1_Mouse1.11214989
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09035509
91* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08342021
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08073964
93* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07520544
94CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06635557
95* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.04887604
96* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.04264974
97CHD1_26751641_Chip-Seq_LNCaP_Human1.00751365
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00678240
99* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98560642
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95408639
101POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.95151762
102NANOG_16153702_ChIP-ChIP_HESCs_Human0.95140655
103POU5F1_16518401_ChIP-PET_MESCs_Mouse0.94798303
104SOX17_20123909_ChIP-Seq_XEN_Mouse0.93422953
105FUS_26573619_Chip-Seq_HEK293_Human0.93265419
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92277014
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92219785
108ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92129950
109TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.91866171
110WT1_19549856_ChIP-ChIP_CCG9911_Human0.91816691
111EWS_26573619_Chip-Seq_HEK293_Human0.91291954
112HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91206887
113KAP1_27257070_Chip-Seq_ESCs_Mouse0.89923439
114CIITA_25753668_ChIP-Seq_RAJI_Human0.89389749
115GATA1_26923725_Chip-Seq_HPCs_Mouse0.86823052
116TP63_19390658_ChIP-ChIP_HaCaT_Human0.84603545
117ELF1_17652178_ChIP-ChIP_JURKAT_Human0.83742574
118ZNF263_19887448_ChIP-Seq_K562_Human0.80348432
119CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.76255897
120TBX5_21415370_ChIP-Seq_HL-1_Mouse0.73775078
121* REST_19997604_ChIP-ChIP_NEURONS_Mouse0.73315894
122HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.72966385
123TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.71468762
124POU5F1_16153702_ChIP-ChIP_HESCs_Human0.71432746
125CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70693096

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004957_abnormal_blastocyst_morpholog3.92917009
2MP0003693_abnormal_embryo_hatching3.63108040
3MP0003123_paternal_imprinting3.36985351
4MP0010094_abnormal_chromosome_stability3.31900156
5MP0003111_abnormal_nucleus_morphology3.13584794
6MP0003077_abnormal_cell_cycle2.80189255
7MP0003283_abnormal_digestive_organ2.77701061
8MP0003806_abnormal_nucleotide_metabolis2.63032078
9MP0002653_abnormal_ependyma_morphology2.48594046
10MP0008057_abnormal_DNA_replication2.41940741
11MP0010352_gastrointestinal_tract_polyps2.40615670
12MP0008058_abnormal_DNA_repair2.38783571
13MP0004133_heterotaxia2.25868492
14MP0008932_abnormal_embryonic_tissue2.21360743
15MP0004233_abnormal_muscle_weight2.17569761
16MP0008877_abnormal_DNA_methylation2.11467255
17MP0003787_abnormal_imprinting2.01328093
18MP0001730_embryonic_growth_arrest1.94686834
19MP0000350_abnormal_cell_proliferation1.93329955
20MP0003121_genomic_imprinting1.91005784
21MP0003890_abnormal_embryonic-extraembry1.72800078
22MP0003941_abnormal_skin_development1.71674144
23MP0010307_abnormal_tumor_latency1.71172897
24MP0003937_abnormal_limbs/digits/tail_de1.68955542
25MP0003119_abnormal_digestive_system1.65918132
26MP0009672_abnormal_birth_weight1.54924148
27MP0001697_abnormal_embryo_size1.54344466
28MP0002084_abnormal_developmental_patter1.53913149
29MP0003122_maternal_imprinting1.52862055
30MP0001188_hyperpigmentation1.50041408
31MP0009697_abnormal_copulation1.49975479
32MP0004197_abnormal_fetal_growth/weight/1.49569613
33MP0008007_abnormal_cellular_replicative1.47523759
34MP0001672_abnormal_embryogenesis/_devel1.46352420
35MP0005380_embryogenesis_phenotype1.46352420
36MP0006292_abnormal_olfactory_placode1.43730870
37MP0002080_prenatal_lethality1.43070267
38MP0002085_abnormal_embryonic_tissue1.40419591
39MP0003718_maternal_effect1.36862456
40MP0009046_muscle_twitch1.34639981
41MP0008995_early_reproductive_senescence1.33717126
42MP0003786_premature_aging1.32981542
43MP0001293_anophthalmia1.32204808
44MP0000358_abnormal_cell_content/1.31800030
45MP0002877_abnormal_melanocyte_morpholog1.30787796
46MP0003984_embryonic_growth_retardation1.25894880
47MP0004264_abnormal_extraembryonic_tissu1.22407471
48MP0002088_abnormal_embryonic_growth/wei1.21667104
49MP0003880_abnormal_central_pattern1.20149639
50MP0002697_abnormal_eye_size1.18697254
51MP0001299_abnormal_eye_distance/1.18528189
52MP0003705_abnormal_hypodermis_morpholog1.16940464
53MP0002086_abnormal_extraembryonic_tissu1.16837522
54MP0006035_abnormal_mitochondrial_morpho1.15024718
55MP0002938_white_spotting1.13506540
56MP0002735_abnormal_chemical_nociception1.13490789
57MP0005266_abnormal_metabolism1.11507116
58MP0002160_abnormal_reproductive_system1.10807301
59MP0001286_abnormal_eye_development1.10615131
60MP0002736_abnormal_nociception_after1.09436836
61MP0005076_abnormal_cell_differentiation1.08932415
62MP0003567_abnormal_fetal_cardiomyocyte1.07384557
63MP0003385_abnormal_body_wall1.07333808
64MP0004859_abnormal_synaptic_plasticity1.06157698
65MP0010234_abnormal_vibrissa_follicle1.02287528
66MP0001968_abnormal_touch/_nociception1.00074123
67MP0003942_abnormal_urinary_system0.98567473
68MP0005384_cellular_phenotype0.97659291
69MP0006276_abnormal_autonomic_nervous0.95419338
70MP0005499_abnormal_olfactory_system0.95407051
71MP0005394_taste/olfaction_phenotype0.95407051
72MP0010030_abnormal_orbit_morphology0.94958639
73MP0009780_abnormal_chondrocyte_physiolo0.93745155
74MP0002184_abnormal_innervation0.93629308
75MP0001145_abnormal_male_reproductive0.93224235
76MP0002734_abnormal_mechanical_nocicepti0.92165712
77MP0002111_abnormal_tail_morphology0.91095673
78MP0002233_abnormal_nose_morphology0.89499485
79MP0002210_abnormal_sex_determination0.89483301
80MP0005623_abnormal_meninges_morphology0.89101849
81MP0008004_abnormal_stomach_pH0.87550903
82MP0000955_abnormal_spinal_cord0.87493075
83MP0003566_abnormal_cell_adhesion0.87435692
84MP0000313_abnormal_cell_death0.87093319
85MP0000678_abnormal_parathyroid_gland0.86833140
86MP0002234_abnormal_pharynx_morphology0.85990206
87MP0006036_abnormal_mitochondrial_physio0.84997052
88MP0004270_analgesia0.84691784
89MP0003221_abnormal_cardiomyocyte_apopto0.84307284
90MP0000516_abnormal_urinary_system0.84081800
91MP0005367_renal/urinary_system_phenotyp0.84081800
92MP0000778_abnormal_nervous_system0.83896698
93MP0005621_abnormal_cell_physiology0.83769417
94MP0000490_abnormal_crypts_of0.82882289
95MP0002081_perinatal_lethality0.82453785
96MP0000566_synostosis0.82352531
97MP0005220_abnormal_exocrine_pancreas0.81597854
98MP0000537_abnormal_urethra_morphology0.80688212
99MP0002269_muscular_atrophy0.79918220
100MP0003635_abnormal_synaptic_transmissio0.78934558
101MP0001986_abnormal_taste_sensitivity0.77466620
102MP0008789_abnormal_olfactory_epithelium0.77284219
103MP0002751_abnormal_autonomic_nervous0.77034299
104MP0000647_abnormal_sebaceous_gland0.76096925
105MP0003935_abnormal_craniofacial_develop0.76037223
106MP0004147_increased_porphyrin_level0.74847847
107MP0000631_abnormal_neuroendocrine_gland0.74789594
108MP0003315_abnormal_perineum_morphology0.74095418
109MP0005389_reproductive_system_phenotype0.73901627
110MP0002332_abnormal_exercise_endurance0.73900064
111MP0004811_abnormal_neuron_physiology0.73765859
112MP0002064_seizures0.73658239
113MP0005645_abnormal_hypothalamus_physiol0.73004281
114MP0001542_abnormal_bone_strength0.72653892
115MP0003861_abnormal_nervous_system0.72269818
116MP0002102_abnormal_ear_morphology0.71856419
117MP0001929_abnormal_gametogenesis0.71373921
118MP0003646_muscle_fatigue0.71341081
119MP0001661_extended_life_span0.71174290
120MP0002152_abnormal_brain_morphology0.70974504
121MP0005083_abnormal_biliary_tract0.70850369
122MP0002063_abnormal_learning/memory/cond0.70727023
123MP0009745_abnormal_behavioral_response0.70551010
124MP0000049_abnormal_middle_ear0.70202994
125MP0009703_decreased_birth_body0.69739976
126MP0005423_abnormal_somatic_nervous0.68973585
127MP0000653_abnormal_sex_gland0.68722789
128MP0002161_abnormal_fertility/fecundity0.68443231
129MP0006072_abnormal_retinal_apoptosis0.68106043
130MP0008770_decreased_survivor_rate0.67721416
131MP0001529_abnormal_vocalization0.67711004
132MP0002733_abnormal_thermal_nociception0.67701747
133MP0004142_abnormal_muscle_tone0.65722074
134MP0004858_abnormal_nervous_system0.64333449
135MP0003186_abnormal_redox_activity0.63559345
136MP0003755_abnormal_palate_morphology0.62029571
137MP0002822_catalepsy0.61998593
138MP0003698_abnormal_male_reproductive0.61944784
139MP0008872_abnormal_physiological_respon0.61319727

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.90319323
2Birth length less than 3rd percentile (HP:0003561)4.03402040
3Irregular epiphyses (HP:0010582)4.01502945
4Ependymoma (HP:0002888)3.94671172
5Carpal bone hypoplasia (HP:0001498)3.56476941
6Reticulocytopenia (HP:0001896)3.39701441
7Abnormality of the astrocytes (HP:0100707)3.19681076
8Astrocytoma (HP:0009592)3.19681076
9Breast hypoplasia (HP:0003187)3.11046242
10Cerebral hypomyelination (HP:0006808)3.01945998
11Agnosia (HP:0010524)2.98659352
12Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.87102483
13Increased nuchal translucency (HP:0010880)2.79724249
14Abnormality of the anterior horn cell (HP:0006802)2.71729692
15Degeneration of anterior horn cells (HP:0002398)2.71729692
16Metaphyseal cupping (HP:0003021)2.58372222
17Medulloblastoma (HP:0002885)2.58039208
18Multiple enchondromatosis (HP:0005701)2.53334822
19Glioma (HP:0009733)2.51839719
20Increased serum pyruvate (HP:0003542)2.49095898
21Abnormality of glycolysis (HP:0004366)2.49095898
22Tongue fasciculations (HP:0001308)2.48235126
23Resting tremor (HP:0002322)2.47889153
24Upper limb muscle weakness (HP:0003484)2.46672718
25Abnormality of chromosome stability (HP:0003220)2.44652669
26Hand muscle atrophy (HP:0009130)2.42794173
27Abnormality of the preputium (HP:0100587)2.36874735
28Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.36496435
29Absent epiphyses (HP:0010577)2.36496435
30Angiofibromas (HP:0010615)2.33997260
31Adenoma sebaceum (HP:0009720)2.33997260
32Aplasia/hypoplasia of the humerus (HP:0006507)2.33824750
33Postnatal microcephaly (HP:0005484)2.32674698
34Abnormal gallbladder physiology (HP:0012438)2.31980769
35Cholecystitis (HP:0001082)2.31980769
36Selective tooth agenesis (HP:0001592)2.31084536
37Abnormal lung lobation (HP:0002101)2.30626518
38Macrocytic anemia (HP:0001972)2.29656018
39Absent radius (HP:0003974)2.26567763
40Rhabdomyosarcoma (HP:0002859)2.26545324
41Abnormality of the ileum (HP:0001549)2.25307600
42Colon cancer (HP:0003003)2.24323510
43Muscle fibrillation (HP:0010546)2.23922080
44Microvesicular hepatic steatosis (HP:0001414)2.23487434
45Horseshoe kidney (HP:0000085)2.22188994
46Atonic seizures (HP:0010819)2.22179042
47Small epiphyses (HP:0010585)2.22136314
48Missing ribs (HP:0000921)2.21179784
49Short humerus (HP:0005792)2.20098879
50Homocystinuria (HP:0002156)2.18378199
51Abnormality of homocysteine metabolism (HP:0010919)2.18378199
52Abnormal mitochondria in muscle tissue (HP:0008316)2.18169549
53Hypoplasia of the capital femoral epiphysis (HP:0003090)2.17747660
54Abnormality of the lower motor neuron (HP:0002366)2.14607718
55Trismus (HP:0000211)2.14229995
56Acute necrotizing encephalopathy (HP:0006965)2.11965396
57Spinal muscular atrophy (HP:0007269)2.11649100
58Aplasia involving forearm bones (HP:0009822)2.09922620
59Absent forearm bone (HP:0003953)2.09922620
60Insomnia (HP:0100785)2.08340326
61Volvulus (HP:0002580)2.07333422
62Calcaneovalgus deformity (HP:0001848)2.05667136
63Vertebral clefting (HP:0008428)2.04744522
64Pterygium (HP:0001059)2.02920675
65Abnormality of cells of the erythroid lineage (HP:0012130)2.01753909
66Glossoptosis (HP:0000162)2.01692558
67Duodenal stenosis (HP:0100867)2.00867119
68Small intestinal stenosis (HP:0012848)2.00867119
69Patellar aplasia (HP:0006443)2.00714624
70Rough bone trabeculation (HP:0100670)2.00484310
71Absent thumb (HP:0009777)1.98308897
72Nephroblastoma (Wilms tumor) (HP:0002667)1.98157324
73Epiphyseal dysplasia (HP:0002656)1.97851661
74Atrophy/Degeneration involving motor neurons (HP:0007373)1.96882664
75Neoplasm of the oral cavity (HP:0100649)1.96614340
76Overlapping toe (HP:0001845)1.96574206
77Vertebral hypoplasia (HP:0008417)1.92824016
78Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.92824016
79Abnormality of the carotid arteries (HP:0005344)1.90254475
80Abnormality of reticulocytes (HP:0004312)1.90141025
81Delayed puberty (HP:0000823)1.89245670
82Abnormality of cochlea (HP:0000375)1.89071581
83Mild short stature (HP:0003502)1.88856460
84Abdominal situs inversus (HP:0003363)1.88856039
85Abnormality of abdominal situs (HP:0011620)1.88856039
86Deformed tarsal bones (HP:0008119)1.88694288
87Acute encephalopathy (HP:0006846)1.88484261
88Abnormality of the labia (HP:0000058)1.87607809
89CNS hypomyelination (HP:0003429)1.87400949
90Abnormal hair whorl (HP:0010721)1.87192398
91Epileptic encephalopathy (HP:0200134)1.86859031
92Embryonal renal neoplasm (HP:0011794)1.86016750
93Increased hepatocellular lipid droplets (HP:0006565)1.85775413
94Ectopic kidney (HP:0000086)1.85647123
95Rib fusion (HP:0000902)1.83385288
96Aplasia/Hypoplasia of the patella (HP:0006498)1.82786731
97Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.82729973
98Neuroblastoma (HP:0003006)1.82729973
99Primitive neuroectodermal tumor (HP:0030065)1.82729973
100Neuroblastic tumors (HP:0004376)1.82729973
101Myelodysplasia (HP:0002863)1.82589995
102Duplicated collecting system (HP:0000081)1.81816997
103Supernumerary spleens (HP:0009799)1.81664995
104Hypoplastic ischia (HP:0003175)1.81196057
105Shawl scrotum (HP:0000049)1.81189215
106Emotional lability (HP:0000712)1.80633032
107Premature ovarian failure (HP:0008209)1.80313531
108Oral leukoplakia (HP:0002745)1.80272097
109Freckling (HP:0001480)1.79887297
110Abnormality of DNA repair (HP:0003254)1.78265637
111Flat capital femoral epiphysis (HP:0003370)1.77355420
112Upper limb amyotrophy (HP:0009129)1.75705388
113Distal upper limb amyotrophy (HP:0007149)1.75705388
114Abnormality of the duodenum (HP:0002246)1.75533088
115Biliary tract neoplasm (HP:0100574)1.74228676
116Thin ribs (HP:0000883)1.73926870
117Breast aplasia (HP:0100783)1.73556040
118Orthostatic hypotension (HP:0001278)1.72687940
119Genu varum (HP:0002970)1.72147619
120Prominent metopic ridge (HP:0005487)1.71733548
121Triphalangeal thumb (HP:0001199)1.71723750
122Megaloblastic anemia (HP:0001889)1.70206219
123Delusions (HP:0000746)1.69376345
124Abnormal number of incisors (HP:0011064)1.69237169
125Focal motor seizures (HP:0011153)1.68771331
126Abnormality of the ischium (HP:0003174)1.68628195
127Unsteady gait (HP:0002317)1.67180311
128* Sloping forehead (HP:0000340)1.67021732
129Abnormality of femoral epiphyses (HP:0006499)1.66640793
130Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.66640793
131Duplication of thumb phalanx (HP:0009942)1.66193836
132Aplasia/Hypoplasia of the uvula (HP:0010293)1.66096864
133Truncus arteriosus (HP:0001660)1.65527380
134* Cortical dysplasia (HP:0002539)1.65312977
135Impaired pain sensation (HP:0007328)1.65253292
136Abnormality of pain sensation (HP:0010832)1.65253292
137Spinal cord compression (HP:0002176)1.64862473
138Poor suck (HP:0002033)1.64540938
139Aplasia/Hypoplasia of the sternum (HP:0006714)1.64411808
140Chromosomal breakage induced by crosslinking agents (HP:0003221)1.64042459
141Meckel diverticulum (HP:0002245)1.64003477
142Neoplasm of the rectum (HP:0100743)1.63698697
143Chromsome breakage (HP:0040012)1.63579921
144Pallor (HP:0000980)1.63502372
145Cafe-au-lait spot (HP:0000957)1.63095666
146Neoplasm of striated muscle (HP:0009728)1.62732656
147Lipid accumulation in hepatocytes (HP:0006561)1.61399230
148Hammertoe (HP:0001765)1.60518557
149Hepatoblastoma (HP:0002884)1.59141965
150Renal agenesis (HP:0000104)1.57425859
151Abnormal number of erythroid precursors (HP:0012131)1.57033307
152Hyperthyroidism (HP:0000836)1.56156669
153Hyperinsulinemic hypoglycemia (HP:0000825)1.55187900
154Abnormality of the calcaneus (HP:0008364)1.53817502
155Neoplasm of the adrenal cortex (HP:0100641)1.53158153
156Facial cleft (HP:0002006)1.52572197
157Choanal atresia (HP:0000453)1.52485408
158Progressive macrocephaly (HP:0004481)1.51541197
159Absent eyelashes (HP:0000561)1.51462738
160Septate vagina (HP:0001153)1.50077381
161Abnormality of serum amino acid levels (HP:0003112)1.49964031
162Abnormality of the metopic suture (HP:0005556)1.49114499
163Abnormal ventriculo-arterial connection (HP:0011563)1.48282127
164Transposition of the great arteries (HP:0001669)1.48282127
165Abnormal connection of the cardiac segments (HP:0011545)1.48282127
166Abnormality of the renal collecting system (HP:0004742)1.47950872
167Overriding aorta (HP:0002623)1.47871968
168Deep palmar crease (HP:0006191)1.47715528
169Abnormality of the pancreatic islet cells (HP:0006476)1.46415544
170Abnormality of endocrine pancreas physiology (HP:0012093)1.46415544

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK63.82415202
2NEK13.74977772
3AKT33.33053762
4WEE13.13144510
5BUB13.05140801
6EIF2AK12.94369390
7CDC72.94320005
8PDK32.54105304
9PDK42.54105304
10EIF2AK32.33590729
11EPHA22.19420933
12SCYL22.07388291
13PDK22.02360805
14PBK1.96657645
15TRIM281.95926956
16TTK1.93664735
17PASK1.86692660
18PLK31.74769347
19CASK1.72759512
20BRSK21.70453790
21TNIK1.69120442
22RPS6KB21.66028473
23WNK41.63992860
24PLK11.61444812
25TAF11.54567780
26LATS21.48981213
27DAPK11.47892909
28PLK21.44062019
29CDK121.42173232
30CCNB11.40715393
31STK391.39288479
32VRK21.38606731
33BCR1.38304722
34MAP3K41.36384077
35PNCK1.35301681
36NME11.35194368
37MAPKAPK31.33746690
38BRSK11.29668423
39AURKA1.29647490
40NEK21.24393552
41MAP3K91.21815761
42NTRK31.17137834
43TLK11.13816585
44BRAF1.13402468
45CHEK21.04300367
46MARK11.04103605
47DDR21.03143879
48VRK11.02902008
49SRPK11.02435571
50ATR1.01766980
51CDK71.00448830
52PRKCI0.99143877
53STK30.98651093
54TESK10.97448281
55CHEK10.95264823
56PAK40.95038156
57EEF2K0.94035207
58MAP3K120.93995572
59BCKDK0.92524198
60ALK0.92356345
61CLK10.90277185
62AURKB0.89349715
63MST40.88430814
64CAMK1G0.87376295
65RPS6KA40.87284863
66CDK190.82322198
67MAP3K80.81656237
68MET0.79059925
69TESK20.78871838
70CAMK1D0.78579569
71KSR20.78542136
72MAP4K20.78360538
73LATS10.78006372
74STK38L0.75979344
75ACVR1B0.71043787
76MINK10.70503074
77CDK140.69525400
78CDK20.68147467
79CDK180.66997315
80EIF2AK20.66221419
81STK160.64880768
82CSNK2A20.64246941
83CDK150.64195225
84SMG10.62964559
85RAF10.62851280
86ERBB40.61383016
87ATM0.60616028
88RPS6KB10.60409949
89CSNK1G10.58242881
90CDK80.57587416
91CDK11A0.57238733
92PAK10.55528500
93CSNK1E0.54683117
94CSNK1A1L0.53726575
95MAP3K110.53106035
96DYRK20.52961556
97FER0.52752559
98FGFR10.51868837
99CDK10.51537427
100STK40.51103318
101MAP3K100.51094524
102LIMK10.50754450
103PLK40.50499247
104GRK50.50386215
105FLT30.48560282
106MST1R0.48253108
107KSR10.47929010
108MAP2K10.47893328
109NUAK10.47609910
110MAP2K70.47480271
111MKNK10.46404683
112CSNK2A10.46105106
113DYRK30.45272453
114CSNK1G30.45157061
115CSNK1G20.44784735
116ZAK0.44388885
117CDK40.44030544
118NME20.43785456
119ERBB30.43661336
120BRD40.41849719
121PRKCG0.40899074
122MKNK20.39980700
123YES10.39066167
124MTOR0.38773587
125ICK0.38725535
126NTRK10.37496338
127ARAF0.37478741
128PKN20.34098225
129PRKDC0.33437944
130AKT20.32516402
131MAP2K40.31956618
132PRKD30.31648740

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009704.44453482
2Mismatch repair_Homo sapiens_hsa034303.26602392
3DNA replication_Homo sapiens_hsa030303.26079418
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.25447926
5Proteasome_Homo sapiens_hsa030503.15162199
6One carbon pool by folate_Homo sapiens_hsa006703.09450038
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.90128430
8RNA transport_Homo sapiens_hsa030132.89628874
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.33182493
10Nucleotide excision repair_Homo sapiens_hsa034202.17411380
11Spliceosome_Homo sapiens_hsa030402.13341791
12RNA polymerase_Homo sapiens_hsa030202.09874817
13Collecting duct acid secretion_Homo sapiens_hsa049662.02031942
14Synaptic vesicle cycle_Homo sapiens_hsa047211.96058720
15Cell cycle_Homo sapiens_hsa041101.93043684
16Ribosome_Homo sapiens_hsa030101.83758881
17Biosynthesis of amino acids_Homo sapiens_hsa012301.75514693
18Vibrio cholerae infection_Homo sapiens_hsa051101.73723756
19Base excision repair_Homo sapiens_hsa034101.67831250
20Homologous recombination_Homo sapiens_hsa034401.60114865
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.58796250
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58519779
23Oxidative phosphorylation_Homo sapiens_hsa001901.55888973
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.52293261
25Steroid biosynthesis_Homo sapiens_hsa001001.48803489
26mRNA surveillance pathway_Homo sapiens_hsa030151.40397065
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.40040966
28Pyrimidine metabolism_Homo sapiens_hsa002401.38425281
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.37905178
30Fanconi anemia pathway_Homo sapiens_hsa034601.34229091
31Oocyte meiosis_Homo sapiens_hsa041141.31894301
32Non-homologous end-joining_Homo sapiens_hsa034501.27835042
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.25002784
34Parkinsons disease_Homo sapiens_hsa050121.24119929
35Basal transcription factors_Homo sapiens_hsa030221.22928209
36Pyruvate metabolism_Homo sapiens_hsa006201.21276184
37Huntingtons disease_Homo sapiens_hsa050161.19840631
38Protein export_Homo sapiens_hsa030601.19545409
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.16690988
40Carbon metabolism_Homo sapiens_hsa012001.15784210
41RNA degradation_Homo sapiens_hsa030181.15691389
42Propanoate metabolism_Homo sapiens_hsa006401.04148834
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03595273
44Fructose and mannose metabolism_Homo sapiens_hsa000511.03108874
45p53 signaling pathway_Homo sapiens_hsa041150.99526350
46Pancreatic secretion_Homo sapiens_hsa049720.94072899
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93483197
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91701755
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89516976
50Purine metabolism_Homo sapiens_hsa002300.85070442
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84109360
52Epstein-Barr virus infection_Homo sapiens_hsa051690.82059947
53Protein digestion and absorption_Homo sapiens_hsa049740.81689407
54Nicotine addiction_Homo sapiens_hsa050330.81550377
55Alcoholism_Homo sapiens_hsa050340.80358190
56Selenocompound metabolism_Homo sapiens_hsa004500.72957663
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71379898
58Vitamin B6 metabolism_Homo sapiens_hsa007500.70040277
59Viral carcinogenesis_Homo sapiens_hsa052030.69900083
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69582994
61Folate biosynthesis_Homo sapiens_hsa007900.68734313
62Fatty acid elongation_Homo sapiens_hsa000620.68599378
63mTOR signaling pathway_Homo sapiens_hsa041500.65670781
64Alzheimers disease_Homo sapiens_hsa050100.65415224
65Long-term potentiation_Homo sapiens_hsa047200.63464825
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59452175
67Systemic lupus erythematosus_Homo sapiens_hsa053220.57443695
68Amphetamine addiction_Homo sapiens_hsa050310.57411501
69* Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57020866
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56992697
71Lysine degradation_Homo sapiens_hsa003100.55740319
72Bladder cancer_Homo sapiens_hsa052190.55551886
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55082697
74Renin-angiotensin system_Homo sapiens_hsa046140.53231648
75Arginine biosynthesis_Homo sapiens_hsa002200.52250842
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.51247889
77Galactose metabolism_Homo sapiens_hsa000520.51167180
78Dopaminergic synapse_Homo sapiens_hsa047280.49213062
79Hippo signaling pathway_Homo sapiens_hsa043900.48575508
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48465932
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48158468
82Wnt signaling pathway_Homo sapiens_hsa043100.46773084
83Melanoma_Homo sapiens_hsa052180.46660578
84HIF-1 signaling pathway_Homo sapiens_hsa040660.43751233
85Type I diabetes mellitus_Homo sapiens_hsa049400.42926815
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42921454
87Butanoate metabolism_Homo sapiens_hsa006500.41199778
88N-Glycan biosynthesis_Homo sapiens_hsa005100.41102159
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40969778
90Insulin secretion_Homo sapiens_hsa049110.40427275
91Cardiac muscle contraction_Homo sapiens_hsa042600.39497129
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38882742
93Gap junction_Homo sapiens_hsa045400.38581835
94Thyroid cancer_Homo sapiens_hsa052160.38339718
95MicroRNAs in cancer_Homo sapiens_hsa052060.37870749
96Hedgehog signaling pathway_Homo sapiens_hsa043400.35821792
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35792644
98Fatty acid metabolism_Homo sapiens_hsa012120.35346434
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.33078558
100Basal cell carcinoma_Homo sapiens_hsa052170.33073785
101Fat digestion and absorption_Homo sapiens_hsa049750.32575173
102Phagosome_Homo sapiens_hsa041450.32568254
103Adherens junction_Homo sapiens_hsa045200.32124882
104Pentose phosphate pathway_Homo sapiens_hsa000300.31927737
105Glucagon signaling pathway_Homo sapiens_hsa049220.29935417
106Legionellosis_Homo sapiens_hsa051340.29754522
107Colorectal cancer_Homo sapiens_hsa052100.29479348
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29231749
109Taste transduction_Homo sapiens_hsa047420.28784370
110GABAergic synapse_Homo sapiens_hsa047270.27782023
111TGF-beta signaling pathway_Homo sapiens_hsa043500.27488292
112Tight junction_Homo sapiens_hsa045300.26877341
113AMPK signaling pathway_Homo sapiens_hsa041520.26709016
114Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.25561878
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25086531
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24704101
117Arginine and proline metabolism_Homo sapiens_hsa003300.23856977
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23807119
119Prostate cancer_Homo sapiens_hsa052150.23787061
120Sulfur relay system_Homo sapiens_hsa041220.23732404
121Estrogen signaling pathway_Homo sapiens_hsa049150.22906860
122* Metabolic pathways_Homo sapiens_hsa011000.22416291
123Phototransduction_Homo sapiens_hsa047440.21600994
124Insulin signaling pathway_Homo sapiens_hsa049100.21113565
125Olfactory transduction_Homo sapiens_hsa047400.20919161
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19334691
127ErbB signaling pathway_Homo sapiens_hsa040120.18929107
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.18542799
129Long-term depression_Homo sapiens_hsa047300.18364702
130Glutathione metabolism_Homo sapiens_hsa004800.15604459

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