ASIC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the amiloride-sensitive Na+ channel and degenerin (NaC/DEG) family, members of which have been identified in many animal species ranging from the nematode to human. The amiloride-sensitive Na(+) channel encoded by this gene is primarily expressed in the small intestine, however, its exact function is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.63305468
2L-phenylalanine catabolic process (GO:0006559)7.63305468
3L-phenylalanine metabolic process (GO:0006558)7.28849725
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.28849725
5aromatic amino acid family catabolic process (GO:0009074)6.97852707
6indole-containing compound catabolic process (GO:0042436)6.37747421
7indolalkylamine catabolic process (GO:0046218)6.37747421
8tryptophan catabolic process (GO:0006569)6.37747421
9kynurenine metabolic process (GO:0070189)6.26515465
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.20672452
11bile acid biosynthetic process (GO:0006699)6.14730941
12tryptophan metabolic process (GO:0006568)5.98882984
13glyoxylate metabolic process (GO:0046487)5.87693195
14alpha-linolenic acid metabolic process (GO:0036109)5.82164242
15urea metabolic process (GO:0019627)5.81115808
16urea cycle (GO:0000050)5.81115808
17negative regulation of fibrinolysis (GO:0051918)5.49674436
18regulation of protein activation cascade (GO:2000257)5.47122425
19complement activation, alternative pathway (GO:0006957)5.45614439
20high-density lipoprotein particle remodeling (GO:0034375)5.36205595
21protein carboxylation (GO:0018214)5.36119368
22peptidyl-glutamic acid carboxylation (GO:0017187)5.36119368
23nitrogen cycle metabolic process (GO:0071941)5.35354683
24regulation of fibrinolysis (GO:0051917)5.31875169
25cysteine metabolic process (GO:0006534)5.27409383
26bile acid metabolic process (GO:0008206)5.18897038
27sulfur amino acid catabolic process (GO:0000098)5.17439387
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.14505371
29regulation of complement activation (GO:0030449)5.09984390
30serine family amino acid catabolic process (GO:0009071)5.08760614
31aromatic amino acid family metabolic process (GO:0009072)5.06745385
32regulation of triglyceride catabolic process (GO:0010896)4.89378274
33tyrosine metabolic process (GO:0006570)4.79331221
34triglyceride homeostasis (GO:0070328)4.73042563
35acylglycerol homeostasis (GO:0055090)4.73042563
36reverse cholesterol transport (GO:0043691)4.69611943
37lysine catabolic process (GO:0006554)4.68766021
38lysine metabolic process (GO:0006553)4.68766021
39alpha-amino acid catabolic process (GO:1901606)4.65192652
40amino-acid betaine metabolic process (GO:0006577)4.65182089
41homocysteine metabolic process (GO:0050667)4.64409272
42protein-lipid complex remodeling (GO:0034368)4.61464123
43macromolecular complex remodeling (GO:0034367)4.61464123
44plasma lipoprotein particle remodeling (GO:0034369)4.61464123
45cellular ketone body metabolic process (GO:0046950)4.59464984
46regulation of cholesterol esterification (GO:0010872)4.59191187
47coenzyme catabolic process (GO:0009109)4.58316332
48indolalkylamine metabolic process (GO:0006586)4.51477270
49negative regulation of sterol transport (GO:0032372)4.50246030
50negative regulation of cholesterol transport (GO:0032375)4.50246030
51phospholipid efflux (GO:0033700)4.45186036
52glycine metabolic process (GO:0006544)4.44321341
53bile acid and bile salt transport (GO:0015721)4.42695522
54cellular biogenic amine catabolic process (GO:0042402)4.40260809
55amine catabolic process (GO:0009310)4.40260809
56cellular glucuronidation (GO:0052695)4.32449579
57cellular amino acid catabolic process (GO:0009063)4.27050991
58plasma lipoprotein particle clearance (GO:0034381)4.21723180
59imidazole-containing compound metabolic process (GO:0052803)4.20220299
60serine family amino acid metabolic process (GO:0009069)4.19250935
61glutamate metabolic process (GO:0006536)4.19136221
62cholesterol efflux (GO:0033344)4.15192858
63ethanol oxidation (GO:0006069)4.14882594
64benzene-containing compound metabolic process (GO:0042537)4.11614459
65arginine metabolic process (GO:0006525)4.07699396
66cytolysis (GO:0019835)4.05660482
67aldehyde catabolic process (GO:0046185)4.04816510
68dicarboxylic acid biosynthetic process (GO:0043650)4.04103059
69serine family amino acid biosynthetic process (GO:0009070)4.02196187
70ketone body metabolic process (GO:1902224)3.97508144
71cellular modified amino acid catabolic process (GO:0042219)3.94688535
72fibrinolysis (GO:0042730)3.91271316
73complement activation, classical pathway (GO:0006958)3.87131918
74plasma lipoprotein particle assembly (GO:0034377)3.86203841
75positive regulation of triglyceride lipase activity (GO:0061365)3.86129113
76positive regulation of lipoprotein lipase activity (GO:0051006)3.86129113
77uronic acid metabolic process (GO:0006063)3.85147561
78glucuronate metabolic process (GO:0019585)3.85147561
79low-density lipoprotein particle remodeling (GO:0034374)3.81076582
80cofactor catabolic process (GO:0051187)3.79552074
81blood coagulation, intrinsic pathway (GO:0007597)3.78174330
82very-low-density lipoprotein particle assembly (GO:0034379)3.76946991
83organic acid catabolic process (GO:0016054)3.76804621
84carboxylic acid catabolic process (GO:0046395)3.76804621
85acetyl-CoA metabolic process (GO:0006084)3.75818545
86complement activation (GO:0006956)3.75112880
87positive regulation of lipid catabolic process (GO:0050996)3.74599760
88regulation of cholesterol homeostasis (GO:2000188)3.71883713
89protein activation cascade (GO:0072376)3.71789701
90regulation of bile acid biosynthetic process (GO:0070857)3.70849788
91cholesterol homeostasis (GO:0042632)3.70558396
92phospholipid homeostasis (GO:0055091)3.67990070
93negative regulation of lipase activity (GO:0060192)3.67502178
94sterol homeostasis (GO:0055092)3.64419807
95drug catabolic process (GO:0042737)3.63956855
96short-chain fatty acid metabolic process (GO:0046459)3.61956913
97monocarboxylic acid catabolic process (GO:0072329)3.52210387
98plasma lipoprotein particle organization (GO:0071827)3.50804319
99positive regulation of fatty acid beta-oxidation (GO:0032000)3.50461116
100NAD biosynthetic process (GO:0009435)3.49314347

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.37311855
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.21883186
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.07879125
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.47821351
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.28140603
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.01334143
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.80910263
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.09451629
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.92170951
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.04496762
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.02825629
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0412754
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94915946
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.59906160
15HTT_18923047_ChIP-ChIP_STHdh_Human1.59482366
16CLOCK_20551151_ChIP-Seq_293T_Human1.48771660
17HNF4A_19822575_ChIP-Seq_HepG2_Human1.40789179
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37678462
19GATA1_22025678_ChIP-Seq_K562_Human1.34455969
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22626509
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20624686
22RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17459461
23ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11022892
24SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99365455
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98407648
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98316063
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.88060034
28ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85391631
29GATA4_25053715_ChIP-Seq_YYC3_Human0.85139630
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82139181
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82046326
32ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81580444
33BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79682642
34AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77967483
35IRF8_22096565_ChIP-ChIP_GC-B_Human0.77871948
36SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75826984
37SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75490173
38RARG_19884340_ChIP-ChIP_MEFs_Mouse0.74541004
39KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74233359
40RARA_24833708_ChIP-Seq_LIVER_Mouse0.71673374
41AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.70601873
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.68912980
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68265881
44ESR2_21235772_ChIP-Seq_MCF-7_Human0.66614162
45NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.66229927
46NRF2_20460467_ChIP-Seq_MEFs_Mouse0.66229927
47RAD21_21589869_ChIP-Seq_MESCs_Mouse0.65934211
48SALL4_18804426_ChIP-ChIP_XEN_Mouse0.64660199
49RARB_24833708_ChIP-Seq_LIVER_Mouse0.64079392
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63786738
51BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60473037
52CDX2_20551321_ChIP-Seq_CACO-2_Human0.59606119
53NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57998682
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.57951685
55CEBPB_22108803_ChIP-Seq_LS180_Human0.57089791
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.55293130
57PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.54188686
58FOXA1_25552417_ChIP-Seq_VCAP_Human0.54138997
59AR_20517297_ChIP-Seq_VCAP_Human0.53389809
60EGR1_19032775_ChIP-ChIP_M12_Human0.52314298
61STAT3_1855785_ChIP-Seq_MESCs_Mouse0.52234547
62TAF15_26573619_Chip-Seq_HEK293_Human0.51468786
63LXR_22292898_ChIP-Seq_THP-1_Human0.51235887
64FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50979483
65MYC_19915707_ChIP-ChIP_AK7_Human0.50909197
66FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50183856
67PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.49514509
68CBP_21632823_ChIP-Seq_H3396_Human0.49389704
69ESET_19884257_ChIP-Seq_ESCs_Mouse0.48886168
70STAT1_17558387_ChIP-Seq_HELA_Human0.47845215
71ZNF263_19887448_ChIP-Seq_K562_Human0.45965592
72PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45724727
73P53_21459846_ChIP-Seq_SAOS-2_Human0.45268422
74PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44891359
75ESR1_21235772_ChIP-Seq_MCF-7_Human0.44795374
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.44276588
77FOXO3_23340844_ChIP-Seq_DLD1_Human0.43816041
78ESR1_20079471_ChIP-ChIP_T-47D_Human0.43008043
79SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42755384
80TAF2_19829295_ChIP-Seq_ESCs_Human0.41816653
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.41807450
82BCAT_22108803_ChIP-Seq_LS180_Human0.41528780
83GATA6_25053715_ChIP-Seq_YYC3_Human0.41414613
84ERG_21242973_ChIP-ChIP_JURKAT_Human0.40793401
85STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.40084387
86PPAR_26484153_Chip-Seq_NCI-H1993_Human0.39890591
87GATA2_19941826_ChIP-Seq_K562_Human0.38983368
88GATA1_19941826_ChIP-Seq_K562_Human0.38556467
89SOX2_20726797_ChIP-Seq_SW620_Human0.37323467
90FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.37256673
91MYC_27129775_Chip-Seq_CORNEA_Mouse0.36982519
92GATA1_19941827_ChIP-Seq_MEL_Mouse0.36956713
93SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.36741184
94ERG_20517297_ChIP-Seq_VCAP_Human0.35973885
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.35759566
96NCOR_22424771_ChIP-Seq_293T_Human0.34867006
97FOXH1_21741376_ChIP-Seq_EPCs_Human0.34035055
98LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.33731108
99GATA3_24758297_ChIP-Seq_MCF-7_Human0.33699576
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.32412485

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.48109005
2MP0005360_urolithiasis7.64684912
3MP0005085_abnormal_gallbladder_physiolo6.49050122
4MP0005365_abnormal_bile_salt6.19699074
5MP0008875_abnormal_xenobiotic_pharmacok4.93302961
6MP0003806_abnormal_nucleotide_metabolis4.50010696
7MP0003252_abnormal_bile_duct3.96424887
8MP0010329_abnormal_lipoprotein_level3.57373840
9MP0009840_abnormal_foam_cell3.11919084
10MP0005083_abnormal_biliary_tract2.99841120
11MP0005332_abnormal_amino_acid2.73952933
12MP0003195_calcinosis2.72245231
13MP0001666_abnormal_nutrient_absorption2.70876335
14MP0003191_abnormal_cellular_cholesterol2.29311683
15MP0000609_abnormal_liver_physiology2.15463071
16MP0002118_abnormal_lipid_homeostasis2.09704342
17MP0004019_abnormal_vitamin_homeostasis2.04881568
18MP0002138_abnormal_hepatobiliary_system1.99412315
19MP0003868_abnormal_feces_composition1.91271146
20MP0005319_abnormal_enzyme/_coenzyme1.80843223
21MP0009697_abnormal_copulation1.70707004
22MP0001764_abnormal_homeostasis1.66749159
23MP0005584_abnormal_enzyme/coenzyme_acti1.55569717
24MP0005451_abnormal_body_composition1.53178597
25MP0003011_delayed_dark_adaptation1.33311786
26MP0003186_abnormal_redox_activity1.21454033
27MP0003656_abnormal_erythrocyte_physiolo1.20470052
28MP0009643_abnormal_urine_homeostasis1.20176168
29MP0005647_abnormal_sex_gland1.19450094
30MP0003705_abnormal_hypodermis_morpholog1.16205380
31MP0000598_abnormal_liver_morphology1.15360971
32MP0002254_reproductive_system_inflammat1.05559934
33MP0000604_amyloidosis1.03381953
34MP0009764_decreased_sensitivity_to1.01217202
35MP0009763_increased_sensitivity_to0.99721486
36MP0010368_abnormal_lymphatic_system0.91125239
37MP0005636_abnormal_mineral_homeostasis0.89224439
38MP0008469_abnormal_protein_level0.87485954
39MP0009642_abnormal_blood_homeostasis0.85823452
40MP0006036_abnormal_mitochondrial_physio0.82886451
41MP0005408_hypopigmentation0.82759893
42MP0005376_homeostasis/metabolism_phenot0.80595719
43MP0005670_abnormal_white_adipose0.79707399
44MP0002876_abnormal_thyroid_physiology0.79337225
45MP0002078_abnormal_glucose_homeostasis0.77922693
46MP0009765_abnormal_xenobiotic_induced0.76469245
47MP0005084_abnormal_gallbladder_morpholo0.74386342
48MP0005220_abnormal_exocrine_pancreas0.72514954
49MP0004130_abnormal_muscle_cell0.69571503
50MP0005266_abnormal_metabolism0.68517090
51MP0005535_abnormal_body_temperature0.67581016
52MP0005334_abnormal_fat_pad0.67311617
53MP0002971_abnormal_brown_adipose0.67127680
54MP0003690_abnormal_glial_cell0.64387813
55MP0001661_extended_life_span0.62846742
56MP0006035_abnormal_mitochondrial_morpho0.62776115
57MP0009053_abnormal_anal_canal0.59454581
58MP0000639_abnormal_adrenal_gland0.57449061
59MP0003329_amyloid_beta_deposits0.57017580
60MP0005448_abnormal_energy_balance0.54384207
61MP0001756_abnormal_urination0.53834779
62MP0004381_abnormal_hair_follicle0.50928541
63MP0005464_abnormal_platelet_physiology0.48464968
64MP0004782_abnormal_surfactant_physiolog0.47364586
65MP0005395_other_phenotype0.46416907
66MP0002928_abnormal_bile_duct0.45962000
67MP0002837_dystrophic_cardiac_calcinosis0.44979263
68MP0002822_catalepsy0.44655270
69MP0003724_increased_susceptibility_to0.43877926
70MP0003638_abnormal_response/metabolism_0.43452132
71MP0008873_increased_physiological_sensi0.42559228
72MP0003718_maternal_effect0.42011784
73MP0002136_abnormal_kidney_physiology0.41871606
74MP0005166_decreased_susceptibility_to0.41645760
75MP0008874_decreased_physiological_sensi0.41610028
76MP0003953_abnormal_hormone_level0.40710298
77MP0005248_abnormal_Harderian_gland0.40033405
78MP0005666_abnormal_adipose_tissue0.39040056
79MP0003075_altered_response_to0.37069705
80MP0009384_cardiac_valve_regurgitation0.36702782
81MP0000579_abnormal_nail_morphology0.36701470
82MP0003436_decreased_susceptibility_to0.35155926
83MP0008872_abnormal_physiological_respon0.34656710
84MP0004264_abnormal_extraembryonic_tissu0.34580483
85MP0002796_impaired_skin_barrier0.34175324
86MP0000230_abnormal_systemic_arterial0.32631730
87MP0006082_CNS_inflammation0.32237262
88MP0009672_abnormal_birth_weight0.31855604
89MP0009115_abnormal_fat_cell0.30214373
90MP0004883_abnormal_blood_vessel0.29433364
91MP0000249_abnormal_blood_vessel0.29010906
92MP0002168_other_aberrant_phenotype0.28914476
93MP0001853_heart_inflammation0.28710980
94MP0001845_abnormal_inflammatory_respons0.28359540
95MP0000427_abnormal_hair_cycle0.27647093
96MP0001243_abnormal_dermal_layer0.27519870
97MP0002970_abnormal_white_adipose0.27473336
98MP0002060_abnormal_skin_morphology0.24995521
99MP0010234_abnormal_vibrissa_follicle0.24331058
100MP0001881_abnormal_mammary_gland0.23969058

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.38775496
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.36094709
3Deep venous thrombosis (HP:0002625)7.34880810
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.66885064
5Prolonged partial thromboplastin time (HP:0003645)6.53132144
6Hypobetalipoproteinemia (HP:0003563)6.50879372
7Xanthomatosis (HP:0000991)6.27645876
8Complement deficiency (HP:0004431)5.68491887
9Hyperlipoproteinemia (HP:0010980)5.48011046
10Hypolipoproteinemia (HP:0010981)4.75131516
11Joint hemorrhage (HP:0005261)4.69767421
12Hyperammonemia (HP:0001987)4.68137682
13Epidermoid cyst (HP:0200040)4.53965372
14Abnormality of the common coagulation pathway (HP:0010990)4.50725734
15Hyperglycinemia (HP:0002154)4.37649503
16Ketosis (HP:0001946)4.36781907
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.33283095
18Fat malabsorption (HP:0002630)4.25470730
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.22423532
20Abnormality of methionine metabolism (HP:0010901)4.22310225
21Abnormality of complement system (HP:0005339)4.15295743
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.13906427
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.06253524
24Hypoalphalipoproteinemia (HP:0003233)4.05118168
25Hypoglycemic coma (HP:0001325)3.89262686
26Abnormality of serine family amino acid metabolism (HP:0010894)3.83468219
27Abnormality of glycine metabolism (HP:0010895)3.83468219
28Abnormality of pyrimidine metabolism (HP:0004353)3.82212399
29Hyperglycinuria (HP:0003108)3.81426680
30Abnormality of the intrinsic pathway (HP:0010989)3.78863538
31Conjugated hyperbilirubinemia (HP:0002908)3.74047217
32Hypercholesterolemia (HP:0003124)3.51259767
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.41682141
34Abnormality of fatty-acid metabolism (HP:0004359)3.41481983
35Hyperbilirubinemia (HP:0002904)3.23673933
36Steatorrhea (HP:0002570)3.22680212
37Hypochromic microcytic anemia (HP:0004840)3.20254075
38Delayed CNS myelination (HP:0002188)3.19425141
39Ketoacidosis (HP:0001993)3.19089831
40Spontaneous abortion (HP:0005268)3.12306176
41Abnormality of serum amino acid levels (HP:0003112)3.07455835
42Abnormality of nucleobase metabolism (HP:0010932)3.04778277
43Hepatocellular carcinoma (HP:0001402)3.00461548
44Myocardial infarction (HP:0001658)2.87330390
45Skin nodule (HP:0200036)2.80258874
46Systemic lupus erythematosus (HP:0002725)2.79859693
47Metabolic acidosis (HP:0001942)2.79719510
48Abnormality of purine metabolism (HP:0004352)2.66061216
49Lethargy (HP:0001254)2.63499874
50Dicarboxylic aciduria (HP:0003215)2.60738712
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.60738712
52Recurrent gram-negative bacterial infections (HP:0005420)2.58562234
53Spastic diplegia (HP:0001264)2.57973307
54Gout (HP:0001997)2.48471327
55Vascular calcification (HP:0004934)2.47717665
56Hypoglycemic seizures (HP:0002173)2.47411602
57Acanthocytosis (HP:0001927)2.45477682
58Cerebral edema (HP:0002181)2.43970167
59Abnormal gallbladder morphology (HP:0012437)2.42377727
60Cholelithiasis (HP:0001081)2.40035748
61Neonatal onset (HP:0003623)2.37340163
62Irritability (HP:0000737)2.35185156
63Malnutrition (HP:0004395)2.34231498
64Cholecystitis (HP:0001082)2.33417307
65Abnormal gallbladder physiology (HP:0012438)2.33417307
66Mitral stenosis (HP:0001718)2.30379533
67Late onset (HP:0003584)2.28021068
68Glomerulonephritis (HP:0000099)2.24789965
69Sensorimotor neuropathy (HP:0007141)2.24510111
70Gingival bleeding (HP:0000225)2.23320595
71Cardiovascular calcification (HP:0011915)2.21042036
72Amyloidosis (HP:0011034)2.20609774
73Pancreatitis (HP:0001733)2.16576561
74Esophageal varix (HP:0002040)2.13621731
75Opisthotonus (HP:0002179)2.12841160
76Brushfield spots (HP:0001088)2.10290565
77Enlarged kidneys (HP:0000105)2.10191742
78Vomiting (HP:0002013)2.08755183
79Generalized aminoaciduria (HP:0002909)2.07493708
80Menorrhagia (HP:0000132)2.06527173
81Hyperinsulinemic hypoglycemia (HP:0000825)2.06136349
82Thrombophlebitis (HP:0004418)2.03233707
83Rickets (HP:0002748)2.01103436
84Abnormality of the gallbladder (HP:0005264)1.98668178
85Poikilocytosis (HP:0004447)1.94162305
86Hemorrhage of the eye (HP:0011885)1.91501301
87Renal cortical cysts (HP:0000803)1.88154998
88Elevated hepatic transaminases (HP:0002910)1.84566612
89Abnormality of vitamin metabolism (HP:0100508)1.84219299
90Abnormality of iron homeostasis (HP:0011031)1.83034629
91Abnormal cartilage morphology (HP:0002763)1.82771998
92Status epilepticus (HP:0002133)1.82657209
93Abnormality of transition element cation homeostasis (HP:0011030)1.81233870
94Hypophosphatemic rickets (HP:0004912)1.80431180
95Abnormal enzyme/coenzyme activity (HP:0012379)1.79987549
96Hyperglycemia (HP:0003074)1.76815404
97Glycosuria (HP:0003076)1.75835593
98Abnormality of urine glucose concentration (HP:0011016)1.75835593
99Abnormality of proline metabolism (HP:0010907)1.75283066
100Hydroxyprolinuria (HP:0003080)1.75283066

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.28361726
2ERN14.79832564
3FGFR44.42548596
4SIK14.13916660
5ERBB43.15822886
6TAOK33.15501174
7INSRR2.84851429
8MAP2K42.42147069
9PIK3CG2.33018813
10MST1R2.26714859
11PKN22.21904422
12MAPK111.97717014
13FLT31.88228679
14TRIB31.74002264
15LATS11.63262343
16ABL21.59869399
17TYK21.54426317
18NEK91.52268249
19PTK61.49632048
20FRK1.42304555
21DAPK21.39327646
22FGFR21.24466951
23JAK21.21856678
24KDR1.20660130
25MAP3K71.19237887
26ERBB21.17427357
27PINK11.16455913
28PRKAA21.07923850
29GRK61.06442321
30MAP3K101.06415038
31MAPK41.04293380
32TBK11.04286579
33MAP3K141.03193964
34PRKCZ0.98989344
35MAP2K30.98187523
36MAP2K60.97580926
37JAK10.97068771
38EPHB10.87812240
39CDK60.85698879
40MAP3K30.85666961
41MET0.84440086
42CAMK2G0.82945488
43STK38L0.80734487
44MAPK120.78252561
45TIE10.76170532
46PRKACG0.74615451
47MAP3K110.74134133
48MAPK150.70088079
49GSK3A0.69246332
50MAPK70.67836367
51EPHA30.65226157
52DYRK1B0.65154612
53IRAK30.63865691
54PRKAA10.63283520
55CAMK1D0.62007368
56CSK0.61566460
57PRKCQ0.59624787
58SGK30.58231410
59PKN10.58147140
60RIPK10.57049648
61CSF1R0.56469867
62MAP2K20.56214575
63TAOK20.55417864
64PDPK10.52548544
65PTK20.51673180
66MAP3K50.49087785
67IKBKE0.48829566
68MAP2K10.48509682
69TGFBR20.47941579
70GRK10.47710924
71EPHA40.47420836
72CSNK1G10.43351570
73IGF1R0.43090480
74SGK20.41814007
75RET0.40075076
76FGFR30.39917951
77CDK40.38125856
78PRKCG0.37690851
79PBK0.36019692
80MAP3K60.35396985
81EGFR0.34538785
82SGK2230.33940941
83SGK4940.33940941
84CAMK40.33502114
85PDK10.32744968
86PAK30.32581131
87MAP3K20.31958477
88MAP3K130.31890913
89LATS20.29092630
90ICK0.28956144
91MAP3K10.28495143
92MTOR0.28169189
93PRKCA0.27240658
94PIK3CA0.24531959
95ABL10.22881346
96AKT30.22149545
97IRAK20.21773506
98CAMK1G0.19897945
99PRKACB0.19677109
100MAPK30.19513836

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.65196228
2Nitrogen metabolism_Homo sapiens_hsa009103.45216123
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.37126972
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.33611970
5Arginine biosynthesis_Homo sapiens_hsa002203.04234063
6Tryptophan metabolism_Homo sapiens_hsa003802.78533470
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.73336472
8Complement and coagulation cascades_Homo sapiens_hsa046102.72989472
9Fatty acid degradation_Homo sapiens_hsa000712.64636491
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62645806
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.51387232
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.47998719
13Butanoate metabolism_Homo sapiens_hsa006502.24097147
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24071167
15Peroxisome_Homo sapiens_hsa041462.13717555
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.06608169
17Propanoate metabolism_Homo sapiens_hsa006401.96732940
18Histidine metabolism_Homo sapiens_hsa003401.91321114
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.90750501
20PPAR signaling pathway_Homo sapiens_hsa033201.90317765
21Fatty acid metabolism_Homo sapiens_hsa012121.86527786
22Chemical carcinogenesis_Homo sapiens_hsa052041.85762977
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.84101450
24beta-Alanine metabolism_Homo sapiens_hsa004101.81204332
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.76195958
26Retinol metabolism_Homo sapiens_hsa008301.71499158
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70021807
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66758259
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66216834
30Staphylococcus aureus infection_Homo sapiens_hsa051501.64430894
31Caffeine metabolism_Homo sapiens_hsa002321.61279449
32Phenylalanine metabolism_Homo sapiens_hsa003601.53096081
33Selenocompound metabolism_Homo sapiens_hsa004501.50485722
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49208346
35Bile secretion_Homo sapiens_hsa049761.48512876
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48193782
37Tyrosine metabolism_Homo sapiens_hsa003501.44819320
38Fatty acid elongation_Homo sapiens_hsa000621.41680365
39Pyruvate metabolism_Homo sapiens_hsa006201.38693814
40Sulfur metabolism_Homo sapiens_hsa009201.33368779
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.28388731
42Starch and sucrose metabolism_Homo sapiens_hsa005001.24302005
43Fat digestion and absorption_Homo sapiens_hsa049751.22328635
44Folate biosynthesis_Homo sapiens_hsa007901.20105382
45ABC transporters_Homo sapiens_hsa020101.19423947
46Biosynthesis of amino acids_Homo sapiens_hsa012301.17553672
47Carbon metabolism_Homo sapiens_hsa012001.11683341
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.11662158
49Steroid biosynthesis_Homo sapiens_hsa001001.06036203
50Vitamin B6 metabolism_Homo sapiens_hsa007501.04998377
51Arginine and proline metabolism_Homo sapiens_hsa003300.99621246
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95060763
53Sulfur relay system_Homo sapiens_hsa041220.93152565
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92543589
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.90042430
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88596556
57Lysine degradation_Homo sapiens_hsa003100.85996120
58Vitamin digestion and absorption_Homo sapiens_hsa049770.82926254
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78821792
60One carbon pool by folate_Homo sapiens_hsa006700.69256202
61Glycerolipid metabolism_Homo sapiens_hsa005610.69086044
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68755649
63Glutathione metabolism_Homo sapiens_hsa004800.61641405
64Pentose phosphate pathway_Homo sapiens_hsa000300.55497376
65Fatty acid biosynthesis_Homo sapiens_hsa000610.51889625
66Prion diseases_Homo sapiens_hsa050200.48327150
67Metabolic pathways_Homo sapiens_hsa011000.46464541
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45304482
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43568653
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30340188
71Linoleic acid metabolism_Homo sapiens_hsa005910.24161387
72Fructose and mannose metabolism_Homo sapiens_hsa000510.23635881
73Galactose metabolism_Homo sapiens_hsa000520.23160890
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.22890415
75Insulin resistance_Homo sapiens_hsa049310.21908392
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18928902
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.15065213
78Glucagon signaling pathway_Homo sapiens_hsa049220.09846527
79AMPK signaling pathway_Homo sapiens_hsa041520.01155694
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.2480440
81Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2412146
82Ether lipid metabolism_Homo sapiens_hsa00565-0.2162923
83Renin-angiotensin system_Homo sapiens_hsa04614-0.2127318
84Amoebiasis_Homo sapiens_hsa05146-0.2121035
85Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2079903
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2012259
87Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1897778
88Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1677537
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1665982
90Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1601926
91Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1468141
92Hepatitis C_Homo sapiens_hsa05160-0.1458985
93African trypanosomiasis_Homo sapiens_hsa05143-0.1420413
94Regulation of autophagy_Homo sapiens_hsa04140-0.1336783
95Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1193774
96Insulin signaling pathway_Homo sapiens_hsa04910-0.1181927
97Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0748896
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0728194
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0668604
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0141439

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