ASH1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1RNA localization (GO:0006403)4.81429315
2positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)4.37287937
3interkinetic nuclear migration (GO:0022027)4.09471814
4signal complex assembly (GO:0007172)4.02386938
5phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.63210985
6cellular response to ethanol (GO:0071361)3.61406918
7locomotory exploration behavior (GO:0035641)3.57616883
8monoubiquitinated protein deubiquitination (GO:0035520)3.53198484
9histone H3-K4 trimethylation (GO:0080182)3.52368508
10positive regulation of signal transduction by p53 class mediator (GO:1901798)3.50185349
11regulation of short-term neuronal synaptic plasticity (GO:0048172)3.46168682
12protein K48-linked deubiquitination (GO:0071108)3.45237089
13protein K11-linked deubiquitination (GO:0035871)3.40054011
14megakaryocyte development (GO:0035855)3.36808081
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.30349244
16lipid translocation (GO:0034204)3.28710803
17phospholipid translocation (GO:0045332)3.28710803
18retrograde transport, vesicle recycling within Golgi (GO:0000301)3.25769089
19neuron remodeling (GO:0016322)3.20682106
20regulation of pigment cell differentiation (GO:0050932)3.19464503
21protein targeting to Golgi (GO:0000042)3.12955042
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.11633042
23cerebellar Purkinje cell differentiation (GO:0021702)3.09870668
24negative regulation of neurotransmitter secretion (GO:0046929)3.01929213
25establishment of protein localization to Golgi (GO:0072600)3.01246697
26regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.98454169
27regulation of skeletal muscle cell differentiation (GO:2001014)2.97939806
28ionotropic glutamate receptor signaling pathway (GO:0035235)2.97185300
29regulation of glutamate receptor signaling pathway (GO:1900449)2.92926939
30vocalization behavior (GO:0071625)2.90920576
31rRNA catabolic process (GO:0016075)2.87521227
32regulation of mitotic spindle organization (GO:0060236)2.87489554
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.83190653
34regulation of nucleobase-containing compound transport (GO:0032239)2.81372278
35synaptic vesicle maturation (GO:0016188)2.77838782
36genitalia morphogenesis (GO:0035112)2.77563924
37regulation of transforming growth factor beta2 production (GO:0032909)2.75252850
38positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.74864625
39* histone lysine methylation (GO:0034968)2.74560488
40cytoplasmic mRNA processing body assembly (GO:0033962)2.73539447
41secretory granule organization (GO:0033363)2.72796754
42positive regulation of developmental pigmentation (GO:0048087)2.71932501
43glutamate receptor signaling pathway (GO:0007215)2.69685459
44insulin-like growth factor receptor signaling pathway (GO:0048009)2.69008602
45peptidyl-lysine methylation (GO:0018022)2.65410852
46neuron maturation (GO:0042551)2.65273411
47establishment of nucleus localization (GO:0040023)2.65224153
48negative regulation of translation, ncRNA-mediated (GO:0040033)2.64088201
49regulation of translation, ncRNA-mediated (GO:0045974)2.64088201
50negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.64088201
51negative regulation of neurotransmitter transport (GO:0051589)2.63057567
52neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.62988358
53central nervous system projection neuron axonogenesis (GO:0021952)2.61359339
54positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.59710540
55regulation of excitatory postsynaptic membrane potential (GO:0060079)2.58068645
56Golgi to endosome transport (GO:0006895)2.57780926
57synaptic vesicle docking involved in exocytosis (GO:0016081)2.57594572
58regulation of hippo signaling (GO:0035330)2.56962213
59detection of calcium ion (GO:0005513)2.56764413
60protein K63-linked deubiquitination (GO:0070536)2.55009403
61regulation of long-term neuronal synaptic plasticity (GO:0048169)2.54848346
62histone H3-K9 methylation (GO:0051567)2.54229635
63central nervous system neuron axonogenesis (GO:0021955)2.53945421
64positive regulation of translational initiation (GO:0045948)2.53242508
65regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.52614671
66cyclic nucleotide catabolic process (GO:0009214)2.52063427
67cAMP catabolic process (GO:0006198)2.51322314
68glutamate secretion (GO:0014047)2.51000688
69regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.50029323
70regulation of synaptic vesicle exocytosis (GO:2000300)2.49395486
71embryonic retina morphogenesis in camera-type eye (GO:0060059)2.48005960
72regulation of postsynaptic membrane potential (GO:0060078)2.47620744
73regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.46336103
74protein localization to synapse (GO:0035418)2.46110079
75synaptic vesicle exocytosis (GO:0016079)2.46108275
76protein targeting to vacuole (GO:0006623)2.45920085
77protein targeting to lysosome (GO:0006622)2.45920085
78establishment of protein localization to vacuole (GO:0072666)2.45920085
79negative regulation of translational initiation (GO:0045947)2.45417883
80cilium or flagellum-dependent cell motility (GO:0001539)2.44429430
81relaxation of cardiac muscle (GO:0055119)2.44301235
82long-term synaptic potentiation (GO:0060291)2.44076541
83negative regulation of cytosolic calcium ion concentration (GO:0051481)2.43363419
84dendrite morphogenesis (GO:0048813)2.43063946
85regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.42594257
86exploration behavior (GO:0035640)2.41963737
87regulation of establishment of cell polarity (GO:2000114)2.41106067
88synaptic transmission, glutamatergic (GO:0035249)2.40904201
89regulation of ARF protein signal transduction (GO:0032012)2.40766937
90cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.40353940
91growth hormone receptor signaling pathway (GO:0060396)2.40202218
92embryonic hemopoiesis (GO:0035162)2.39233242
93neural tube formation (GO:0001841)2.39077347
94histone H3-K4 methylation (GO:0051568)2.38842927
95presynaptic membrane assembly (GO:0097105)2.38163244
96nucleus localization (GO:0051647)2.37540328
97long-term memory (GO:0007616)2.36596325
98cellular potassium ion homeostasis (GO:0030007)2.35779239
99positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.35355483
100regulation of neuronal synaptic plasticity (GO:0048168)2.35298346
101regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.34448657
102synaptic vesicle endocytosis (GO:0048488)2.33729955
103striated muscle atrophy (GO:0014891)2.33641173
104negative regulation of synaptic transmission, GABAergic (GO:0032229)2.32264924
105neuron cell-cell adhesion (GO:0007158)2.31655076
106macroautophagy (GO:0016236)2.30967457
107axonal fasciculation (GO:0007413)2.30787300
108innervation (GO:0060384)2.30597134
109platelet formation (GO:0030220)2.30079829
110skeletal muscle adaptation (GO:0043501)2.29963341
111histone H3-K9 modification (GO:0061647)2.29509194
112protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.29209447
113dendritic spine morphogenesis (GO:0060997)2.28980150
114coronary vasculature morphogenesis (GO:0060977)2.28902943
115neuron-neuron synaptic transmission (GO:0007270)2.28262413
116positive regulation of cardiac muscle hypertrophy (GO:0010613)2.27161580
117positive regulation of muscle hypertrophy (GO:0014742)2.27161580
118inner ear receptor cell development (GO:0060119)2.25371438
119activation of protein kinase A activity (GO:0034199)2.23981316
120intestinal epithelial cell development (GO:0060576)2.23951626
121regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.21765786
122positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.21765786
123retina layer formation (GO:0010842)2.21535714
124regulation of energy homeostasis (GO:2000505)2.21517780
125protein localization to Golgi apparatus (GO:0034067)2.21136789
126cellular response to growth hormone stimulus (GO:0071378)2.21081398
127peptidyl-lysine trimethylation (GO:0018023)2.20865562
128nuclear pore complex assembly (GO:0051292)2.20586223
129snRNA transcription (GO:0009301)2.19783371
130regulation of synaptic vesicle transport (GO:1902803)2.19433244
131membrane depolarization during action potential (GO:0086010)2.19247744
132positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.19015094
133gamma-aminobutyric acid signaling pathway (GO:0007214)2.18295083
134chemosensory behavior (GO:0007635)2.17944487
135neuron recognition (GO:0008038)2.16995759
136regulation of dendritic spine morphogenesis (GO:0061001)2.16614398
137early endosome to late endosome transport (GO:0045022)2.16587681
138startle response (GO:0001964)2.16569269
139gamma-aminobutyric acid transport (GO:0015812)2.16238469
140auditory receptor cell differentiation (GO:0042491)2.16027051
141regulation of MHC class I biosynthetic process (GO:0045343)2.15373143
142potassium ion import (GO:0010107)2.15080330
143positive regulation of receptor activity (GO:2000273)2.14556284
144regulation of establishment or maintenance of cell polarity (GO:0032878)2.14166717
145negative regulation of complement activation (GO:0045916)2.13159571
146regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.12406489
147histone H3-K36 demethylation (GO:0070544)2.12329311
148layer formation in cerebral cortex (GO:0021819)2.12288343
149regulation of synaptic plasticity (GO:0048167)2.12216725
150definitive hemopoiesis (GO:0060216)2.11734915
151vesicle transport along microtubule (GO:0047496)2.11521954
152inositol metabolic process (GO:0006020)2.11360924
153G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.11173982
154cell communication by electrical coupling (GO:0010644)2.11142101
155membrane depolarization (GO:0051899)2.10915953
156positive regulation of cardiac muscle cell differentiation (GO:2000727)2.10706554
157microtubule anchoring (GO:0034453)2.10106839
158iron ion import (GO:0097286)2.09729440
159stress granule assembly (GO:0034063)2.09507014
160nerve growth factor signaling pathway (GO:0038180)2.09148025
161neurotransmitter secretion (GO:0007269)2.08536990
162regulation of synaptic transmission, glutamatergic (GO:0051966)2.08406911
163regulation of synapse structural plasticity (GO:0051823)2.07853270
164regulation of fatty acid beta-oxidation (GO:0031998)2.06798216
165response to histamine (GO:0034776)2.06796430
166regulation of vesicle fusion (GO:0031338)2.06552526
167long term synaptic depression (GO:0060292)2.06406954
168positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.06370229
169postsynaptic membrane organization (GO:0001941)2.05404611
170regulation of neurotransmitter secretion (GO:0046928)2.04999474
171neurotransmitter-gated ion channel clustering (GO:0072578)2.03457417
172regulation of cell communication by electrical coupling (GO:0010649)2.03331374
173presynaptic membrane organization (GO:0097090)2.02290226
174suckling behavior (GO:0001967)2.01039949
175cardiac conduction (GO:0061337)1.99249618
176visual learning (GO:0008542)1.98441472
177regulation of clathrin-mediated endocytosis (GO:2000369)1.97859048
178regulation of axon extension involved in axon guidance (GO:0048841)1.96995858
179positive regulation of membrane potential (GO:0045838)1.95586485

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.62914948
2GBX2_23144817_ChIP-Seq_PC3_Human3.37202376
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35479156
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.24645692
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.21040168
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.11580990
7DROSHA_22980978_ChIP-Seq_HELA_Human2.05242576
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.01438315
9SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.00810964
10JARID2_20064375_ChIP-Seq_MESCs_Mouse1.97684558
11ZNF217_24962896_ChIP-Seq_MCF-7_Human1.93567353
12AR_21572438_ChIP-Seq_LNCaP_Human1.83343467
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82975873
14FLI1_27457419_Chip-Seq_LIVER_Mouse1.80987953
15PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80869280
16* SMAD4_21799915_ChIP-Seq_A2780_Human1.78666962
17EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77687445
18RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77687445
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76928775
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73052000
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69878795
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.67203585
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66895190
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66145698
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64619520
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.64578644
27TP53_16413492_ChIP-PET_HCT116_Human1.63853702
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63431637
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.62693872
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61610493
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.58335718
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58196910
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.58159758
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.57707561
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.56140725
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.56064788
37ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.54975059
38P300_19829295_ChIP-Seq_ESCs_Human1.54628284
39ARNT_22903824_ChIP-Seq_MCF-7_Human1.53328716
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52798568
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52484788
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52424792
43AHR_22903824_ChIP-Seq_MCF-7_Human1.52331174
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.52045084
45STAT3_23295773_ChIP-Seq_U87_Human1.50627645
46STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.49614905
47TAF15_26573619_Chip-Seq_HEK293_Human1.41190077
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.37838694
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.37260624
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.36953214
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35091864
52TCF4_23295773_ChIP-Seq_U87_Human1.34132963
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34122906
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33680201
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33234352
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33204570
57RARB_27405468_Chip-Seq_BRAIN_Mouse1.32938893
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31493229
59AR_25329375_ChIP-Seq_VCAP_Human1.31357236
60ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30476226
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30377765
62CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29347663
63* SOX2_21211035_ChIP-Seq_LN229_Gbm1.28960175
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27265591
65EP300_21415370_ChIP-Seq_HL-1_Mouse1.26644494
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26050584
67CBP_20019798_ChIP-Seq_JUKART_Human1.26050584
68EZH2_27294783_Chip-Seq_ESCs_Mouse1.25464169
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24445531
70CTNNB1_20460455_ChIP-Seq_HCT116_Human1.23093886
71P53_22387025_ChIP-Seq_ESCs_Mouse1.22986504
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22685476
73AR_19668381_ChIP-Seq_PC3_Human1.22411328
74SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22091887
75REST_21632747_ChIP-Seq_MESCs_Mouse1.21742829
76FUS_26573619_Chip-Seq_HEK293_Human1.20654054
77CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.20456213
78BCAT_22108803_ChIP-Seq_LS180_Human1.20237398
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19999506
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19999506
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19819247
82TP53_18474530_ChIP-ChIP_U2OS_Human1.19262490
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18946216
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18936285
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18858183
86SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18113840
87GATA1_22025678_ChIP-Seq_K562_Human1.17867618
88* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17499903
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17168078
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.16035743
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15875619
92RXR_22108803_ChIP-Seq_LS180_Human1.15612792
93TCF4_18268006_ChIP-ChIP_LS174T_Human1.15205626
94FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14609276
95NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11292961
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.10881810
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10522059
98RUNX2_22187159_ChIP-Seq_PCA_Human1.10471377
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10453973
100FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.09659038
101P300_18555785_Chip-Seq_ESCs_Mouse1.08071257
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07197391
103ZNF274_21170338_ChIP-Seq_K562_Hela1.06610868
104IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05904653
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.05722650
106FOXA2_19822575_ChIP-Seq_HepG2_Human1.05389354
107LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04643711
108IGF1R_20145208_ChIP-Seq_DFB_Human1.03914009
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03799746
110KDM2B_26808549_Chip-Seq_REH_Human1.03746466
111* E2F1_18555785_Chip-Seq_ESCs_Mouse1.02941699
112OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02828529
113TCF4_22108803_ChIP-Seq_LS180_Human1.02221856
114EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01481246
115SOX2_18555785_Chip-Seq_ESCs_Mouse1.00736038
116SALL1_21062744_ChIP-ChIP_HESCs_Human1.00371669
117CJUN_26792858_Chip-Seq_BT549_Human1.00136823
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.99987664
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99822935
120PRDM14_20953172_ChIP-Seq_ESCs_Human0.99732784
121NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98538302
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98538302
123DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98142634
124FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97594573
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97270955
126EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96667309
127P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96313617
128WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96156242
129ER_23166858_ChIP-Seq_MCF-7_Human0.95938018
130ISL1_27105846_Chip-Seq_CPCs_Mouse0.95890449
131MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95872108
132ESR1_20079471_ChIP-ChIP_T-47D_Human0.95053054

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.39815953
2MP0004859_abnormal_synaptic_plasticity4.40362235
3MP0009780_abnormal_chondrocyte_physiolo3.36840164
4MP0003646_muscle_fatigue3.24369880
5MP0008057_abnormal_DNA_replication2.96179919
6MP0003787_abnormal_imprinting2.71044410
7MP0003635_abnormal_synaptic_transmissio2.69215342
8MP0003045_fibrosis2.48208380
9MP0003880_abnormal_central_pattern2.46043173
10MP0009745_abnormal_behavioral_response2.21137162
11MP0004147_increased_porphyrin_level2.12791097
12MP0002063_abnormal_learning/memory/cond2.08889064
13MP0004270_analgesia2.07745989
14MP0001486_abnormal_startle_reflex2.02051730
15MP0009046_muscle_twitch1.92752263
16MP0005646_abnormal_pituitary_gland1.90587630
17MP0002572_abnormal_emotion/affect_behav1.86005428
18MP0002064_seizures1.84170878
19MP0002160_abnormal_reproductive_system1.80026669
20MP0005409_darkened_coat_color1.74303900
21MP0002009_preneoplasia1.70123575
22MP0003183_abnormal_peptide_metabolism1.68300855
23MP0000427_abnormal_hair_cycle1.66331762
24MP0004036_abnormal_muscle_relaxation1.65769407
25MP0003122_maternal_imprinting1.65136291
26MP0001919_abnormal_reproductive_system1.63998315
27MP0001188_hyperpigmentation1.58207630
28MP0008961_abnormal_basal_metabolism1.58171833
29MP0008877_abnormal_DNA_methylation1.57773115
30MP0010352_gastrointestinal_tract_polyps1.57422050
31MP0002638_abnormal_pupillary_reflex1.57345319
32MP0001299_abnormal_eye_distance/1.55671911
33MP0008569_lethality_at_weaning1.52162595
34MP0005645_abnormal_hypothalamus_physiol1.50054942
35MP0001727_abnormal_embryo_implantation1.48789347
36MP0001501_abnormal_sleep_pattern1.48742951
37MP0002909_abnormal_adrenal_gland1.47241649
38MP0005551_abnormal_eye_electrophysiolog1.42173914
39MP0002272_abnormal_nervous_system1.42036509
40MP0004145_abnormal_muscle_electrophysio1.40272579
41MP0005503_abnormal_tendon_morphology1.39867136
42MP0004510_myositis1.37995753
43MP0001346_abnormal_lacrimal_gland1.36053012
44MP0003300_gastrointestinal_ulcer1.35427827
45MP0001177_atelectasis1.34089245
46MP0005423_abnormal_somatic_nervous1.34010843
47MP0001502_abnormal_circadian_rhythm1.34000763
48MP0001968_abnormal_touch/_nociception1.33553553
49MP0002734_abnormal_mechanical_nocicepti1.27300835
50MP0000778_abnormal_nervous_system1.27243189
51MP0002067_abnormal_sensory_capabilities1.25563469
52MP0001440_abnormal_grooming_behavior1.24959915
53MP0004084_abnormal_cardiac_muscle1.22474080
54MP0000751_myopathy1.22087171
55MP0004885_abnormal_endolymph1.18839369
56MP0004233_abnormal_muscle_weight1.18338936
57MP0002557_abnormal_social/conspecific_i1.16290418
58MP0002108_abnormal_muscle_morphology1.15991809
59MP0005171_absent_coat_pigmentation1.15706959
60MP0004381_abnormal_hair_follicle1.14580904
61MP0004043_abnormal_pH_regulation1.14060007
62MP0004808_abnormal_hematopoietic_stem1.13981542
63MP0001879_abnormal_lymphatic_vessel1.13549879
64MP0004215_abnormal_myocardial_fiber1.10777647
65MP0004484_altered_response_of1.10230578
66MP0002166_altered_tumor_susceptibility1.09759213
67MP0004924_abnormal_behavior1.09462410
68MP0005386_behavior/neurological_phenoty1.09462410
69MP0000013_abnormal_adipose_tissue1.08729540
70MP0002837_dystrophic_cardiac_calcinosis1.06250814
71MP0005076_abnormal_cell_differentiation1.06146228
72MP0005174_abnormal_tail_pigmentation1.05292926
73MP0002971_abnormal_brown_adipose1.04369187
74MP0004085_abnormal_heartbeat1.02629030
75MP0002184_abnormal_innervation1.02559963
76MP0000003_abnormal_adipose_tissue1.02423785
77MP0009115_abnormal_fat_cell1.01725880
78MP0003890_abnormal_embryonic-extraembry1.01425241
79MP0003633_abnormal_nervous_system1.00954589
80MP0001873_stomach_inflammation0.99924945
81MP0002928_abnormal_bile_duct0.98912775
82MP0005167_abnormal_blood-brain_barrier0.97564211
83MP0005389_reproductive_system_phenotype0.97133063
84MP0000015_abnormal_ear_pigmentation0.97118773
85MP0003763_abnormal_thymus_physiology0.95938113
86MP0003121_genomic_imprinting0.95550093
87MP0002168_other_aberrant_phenotype0.94439097
88MP0000470_abnormal_stomach_morphology0.91998144
89MP0004130_abnormal_muscle_cell0.91824077
90MP0004134_abnormal_chest_morphology0.90113888
91MP0004811_abnormal_neuron_physiology0.88017568
92MP0001270_distended_abdomen0.86723933
93MP0002822_catalepsy0.84366869
94MP0003632_abnormal_nervous_system0.83851634
95MP0002882_abnormal_neuron_morphology0.83692399
96MP0000627_abnormal_mammary_gland0.83206932
97MP0002896_abnormal_bone_mineralization0.83188356
98MP0002090_abnormal_vision0.82979365
99MP0010386_abnormal_urinary_bladder0.82685954
100MP0003195_calcinosis0.82462853
101MP0002735_abnormal_chemical_nociception0.79470230
102MP0001970_abnormal_pain_threshold0.79120982
103MP0003868_abnormal_feces_composition0.78709966
104MP0003091_abnormal_cell_migration0.78708898
105MP0002006_tumorigenesis0.78157847
106MP0002876_abnormal_thyroid_physiology0.78083447
107MP0005187_abnormal_penis_morphology0.77460260
108MP0003172_abnormal_lysosome_physiology0.76858908
109MP0001851_eye_inflammation0.76835200
110MP0010678_abnormal_skin_adnexa0.75860294
111MP0003936_abnormal_reproductive_system0.75357178
112MP0005248_abnormal_Harderian_gland0.74155088
113MP0000955_abnormal_spinal_cord0.73741355
114MP0005275_abnormal_skin_tensile0.73235044
115MP0006072_abnormal_retinal_apoptosis0.73022636
116MP0003935_abnormal_craniofacial_develop0.72896198
117MP0000462_abnormal_digestive_system0.72679186
118MP0010368_abnormal_lymphatic_system0.72677573
119MP0001324_abnormal_eye_pigmentation0.72346113
120MP0002733_abnormal_thermal_nociception0.72314805
121MP0001984_abnormal_olfaction0.72110268
122MP0003631_nervous_system_phenotype0.71315005
123MP0000428_abnormal_craniofacial_morphol0.70400743
124MP0003385_abnormal_body_wall0.70043086
125MP0003690_abnormal_glial_cell0.69222637
126MP0005253_abnormal_eye_physiology0.67415253
127MP0000383_abnormal_hair_follicle0.67353111
128MP0002229_neurodegeneration0.66329714
129MP0000631_abnormal_neuroendocrine_gland0.66062786
130MP0002066_abnormal_motor_capabilities/c0.65129623
131MP0000647_abnormal_sebaceous_gland0.63402334
132MP0002998_abnormal_bone_remodeling0.62799291
133MP0005257_abnormal_intraocular_pressure0.61854240
134MP0002736_abnormal_nociception_after0.61538317
135MP0002877_abnormal_melanocyte_morpholog0.61537428
136MP0009703_decreased_birth_body0.61197652
137MP0002152_abnormal_brain_morphology0.61056110

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)3.57853741
2Macroorchidism (HP:0000053)3.52202179
3Menstrual irregularities (HP:0000858)3.32525284
4Febrile seizures (HP:0002373)3.31483125
5Abnormality of the fingertips (HP:0001211)3.25150172
6Genetic anticipation (HP:0003743)3.16147332
7Absent frontal sinuses (HP:0002688)3.02825960
8Progressive cerebellar ataxia (HP:0002073)2.97561252
9Heterotopia (HP:0002282)2.90701481
10Focal seizures (HP:0007359)2.88475071
11Narrow palate (HP:0000189)2.85776041
12Epileptic encephalopathy (HP:0200134)2.83825254
13Acute myeloid leukemia (HP:0004808)2.75617513
14Broad-based gait (HP:0002136)2.68476248
15Abnormality of the nasal septum (HP:0000419)2.68070861
16Volvulus (HP:0002580)2.66699023
17Tubulointerstitial nephritis (HP:0001970)2.64660799
18Action tremor (HP:0002345)2.55356423
19Excessive salivation (HP:0003781)2.52313440
20Drooling (HP:0002307)2.52313440
21Gaze-evoked nystagmus (HP:0000640)2.49422922
22Midline defect of the nose (HP:0004122)2.45601890
23Protruding tongue (HP:0010808)2.42225917
24Abnormality of the renal cortex (HP:0011035)2.41277437
25Hypoplastic ischia (HP:0003175)2.40092192
26Hyperventilation (HP:0002883)2.34443244
27Atonic seizures (HP:0010819)2.33068206
28Obstructive sleep apnea (HP:0002870)2.31203819
29Abnormality of the ischium (HP:0003174)2.29793282
30Impaired vibratory sensation (HP:0002495)2.29449199
31Blue irides (HP:0000635)2.28627767
32Abnormality of the renal medulla (HP:0100957)2.27606882
33Partial agenesis of the corpus callosum (HP:0001338)2.26685924
34Widely spaced teeth (HP:0000687)2.23892739
35Urinary bladder sphincter dysfunction (HP:0002839)2.23320900
36Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.22156613
37Aqueductal stenosis (HP:0002410)2.20962899
38Truncal ataxia (HP:0002078)2.20660693
39Neoplasm of the tracheobronchial system (HP:0100552)2.20654505
40Sandal gap (HP:0001852)2.18059629
41Urethral obstruction (HP:0000796)2.15515265
42Dysmetric saccades (HP:0000641)2.15122416
43Tented upper lip vermilion (HP:0010804)2.14839013
44Scanning speech (HP:0002168)2.14797923
45Prolonged QT interval (HP:0001657)2.13999195
46Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.13982546
47Gonadotropin excess (HP:0000837)2.08465660
48Hyperinsulinemic hypoglycemia (HP:0000825)2.08084361
49Obsessive-compulsive behavior (HP:0000722)2.04587045
50Abnormality of incisor morphology (HP:0011063)2.04180864
51Impaired smooth pursuit (HP:0007772)2.02019165
52Exotropia (HP:0000577)1.99499231
53Absent speech (HP:0001344)1.98980961
54Long eyelashes (HP:0000527)1.98870582
55Abnormality of the frontal sinuses (HP:0002687)1.97254456
56Thickened helices (HP:0000391)1.95993873
57Nephronophthisis (HP:0000090)1.95514785
58Truncal obesity (HP:0001956)1.95093258
59Cystic hygroma (HP:0000476)1.95055914
60Open mouth (HP:0000194)1.93322039
61Absence seizures (HP:0002121)1.92141784
62Syringomyelia (HP:0003396)1.90826075
63Spinal cord lesions (HP:0100561)1.90826075
64Neonatal hypoglycemia (HP:0001998)1.90052232
65Thick eyebrow (HP:0000574)1.87862915
66Lower limb amyotrophy (HP:0007210)1.86871822
67Prominent nose (HP:0000448)1.86831471
68Dysdiadochokinesis (HP:0002075)1.86643929
69Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.85813715
70Aortic aneurysm (HP:0004942)1.85456108
71Postural instability (HP:0002172)1.85149839
72Alveolar cell carcinoma (HP:0006519)1.84071369
73Generalized hypopigmentation of hair (HP:0011358)1.83732215
74Cone-rod dystrophy (HP:0000548)1.83490382
75Fatigue (HP:0012378)1.82904536
76Hypoplastic iliac wings (HP:0002866)1.82800932
77Broad metatarsal (HP:0001783)1.82600565
78Abnormality of chromosome segregation (HP:0002916)1.81677623
79Cubitus valgus (HP:0002967)1.81598844
80Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.81097672
81Hypokalemic alkalosis (HP:0001949)1.79868058
82Deeply set eye (HP:0000490)1.79286615
83Inappropriate behavior (HP:0000719)1.78054605
84Abnormality of salivation (HP:0100755)1.77904365
85Short chin (HP:0000331)1.77107185
86Submucous cleft hard palate (HP:0000176)1.76906764
87Bulbous nose (HP:0000414)1.76507499
88Curly hair (HP:0002212)1.75470361
89Lip pit (HP:0100267)1.75149373
90Smooth philtrum (HP:0000319)1.73045493
91Abnormality of potassium homeostasis (HP:0011042)1.73009455
92Arterial tortuosity (HP:0005116)1.71506860
93Stereotypic behavior (HP:0000733)1.71491229
94Abnormality of ocular smooth pursuit (HP:0000617)1.71422578
95Abnormality of the right ventricle (HP:0001707)1.71039806
96Chronic hepatic failure (HP:0100626)1.70802511
97Subacute progressive viral hepatitis (HP:0006572)1.69650390
98Dialeptic seizures (HP:0011146)1.68944961
99Hypoplasia of the maxilla (HP:0000327)1.68856667
100Abnormality of the epiphyses of the hand (HP:0005924)1.68785065
101Resting tremor (HP:0002322)1.68230686
102Papilledema (HP:0001085)1.68215858
1032-3 toe syndactyly (HP:0004691)1.67049690
104Laryngomalacia (HP:0001601)1.66659165
105Tubular atrophy (HP:0000092)1.66061638
106Round face (HP:0000311)1.65947760
107Tapered finger (HP:0001182)1.65841473
108Syncope (HP:0001279)1.65520589
109Atrial fibrillation (HP:0005110)1.65066932
110Absent eyebrow (HP:0002223)1.65031118
111Deep philtrum (HP:0002002)1.64733033
112Impaired social interactions (HP:0000735)1.64301404
113Abnormal social behavior (HP:0012433)1.64301404
114Renal cortical cysts (HP:0000803)1.64086143
115Trigonocephaly (HP:0000243)1.64010036
116Vertebral arch anomaly (HP:0008438)1.63183385
117Thyroiditis (HP:0100646)1.62889355
118Poor eye contact (HP:0000817)1.62638683
119Abnormality of the axillary hair (HP:0100134)1.62498686
120Abnormality of secondary sexual hair (HP:0009888)1.62498686
121Short 4th metacarpal (HP:0010044)1.61948558
122Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.61948558
123Overgrowth (HP:0001548)1.60996390
124Spondylolisthesis (HP:0003302)1.59805269
125Vascular tortuosity (HP:0004948)1.59081695
126Generalized tonic-clonic seizures (HP:0002069)1.59041473
127Visual hallucinations (HP:0002367)1.58909924
128Congenital stationary night blindness (HP:0007642)1.58217703
129Abnormal hair whorl (HP:0010721)1.57770386
130Hyperkalemia (HP:0002153)1.57221591
131Cerebral aneurysm (HP:0004944)1.56122512
132Papillary thyroid carcinoma (HP:0002895)1.55481505
133Shawl scrotum (HP:0000049)1.55415094
134Cerebellar dysplasia (HP:0007033)1.55024880
135Clumsiness (HP:0002312)1.54252502
136Fair hair (HP:0002286)1.54182121
137Mitral valve prolapse (HP:0001634)1.54050468
138Limited elbow extension (HP:0001377)1.53572957
139Hemiplegia (HP:0002301)1.53248473
140Abnormality of the parietal bone (HP:0002696)1.51980593
141Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.51833403
142Distal lower limb amyotrophy (HP:0008944)1.51654464
143Limited hip movement (HP:0008800)1.51026464
144Abnormality of the pubic bones (HP:0003172)1.49814053
145Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.49781182

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.20971953
2NLK3.03398442
3CAMK1G2.78901933
4INSRR2.57140767
5EPHA42.48783592
6CAMK1D2.19044914
7SIK22.15563481
8TNIK2.02952534
9MAP3K41.99793154
10FRK1.91608358
11SGK21.88916038
12MAP2K71.73645401
13SGK31.67245662
14DMPK1.63179396
15BRD41.59405723
16LATS11.58297131
17RIPK41.57051894
18CDK121.53740232
19WNK11.49482378
20GRK11.48474427
21SIK11.47233643
22MAP3K131.46964952
23FGFR21.46938451
24STK38L1.44720149
25PRKD31.37746671
26NTRK21.29462056
27RIPK11.28884749
28SIK31.27546775
29MARK21.26693759
30NUAK11.26440992
31FGFR31.25312721
32AKT31.22336736
33SGK4941.19516163
34SGK2231.19516163
35CDC42BPA1.17962100
36OBSCN1.17164868
37MAP3K71.16021120
38PIK3CG1.14877392
39PIK3CA1.11115645
40PRKCH1.10559071
41PRKCI1.10300469
42EPHA31.10050037
43SGK11.06253910
44CAMK11.03500910
45JAK11.02298694
46STK381.01236400
47MELK0.99836727
48ZAK0.99591395
49TRPM70.99397032
50PLK20.97880075
51HIPK20.95745306
52MAP3K20.94229868
53MAP3K90.93972334
54CAMKK10.92453766
55DAPK20.92343179
56CASK0.91244012
57CAMKK20.91027326
58CAMK40.90758457
59MAP2K40.90062486
60CDK50.86848078
61PDGFRB0.86706050
62TAOK30.84982950
63MAPK130.84932047
64MARK10.84924329
65PNCK0.80934986
66NEK60.79638687
67CDK30.78432420
68STK390.78292013
69PRPF4B0.72879267
70EIF2AK30.71213158
71RET0.70457989
72PDGFRA0.70222437
73MAPK70.70184484
74TRIB30.69923264
75PRKAA20.69824859
76STK110.69732563
77PRKD20.69052821
78YES10.68546345
79ERBB30.67680583
80PRKCE0.66109975
81MINK10.66004411
82PRKCG0.65181498
83MET0.64909839
84TNK20.63995433
85FES0.63352573
86NTRK10.60502168
87PRKCZ0.59898895
88MAPK100.59510165
89FER0.58244895
90CHUK0.58185621
91PRKCQ0.57085599
92CAMK2A0.56457725
93BMPR20.56189622
94MAP4K20.55180722
95PTK2B0.55105074
96DYRK1A0.54216120
97PDK10.53256165
98KSR10.52690095
99ERBB20.52289152
100RPS6KA30.51943510
101LMTK20.51201225
102PAK60.51122860
103PAK30.49608135
104RPS6KB10.49081607
105STK30.48277407
106FYN0.47496502
107BLK0.46924423
108CDK90.46113045
109PRKG10.45980236
110MAPK120.45865028
111DDR20.45722596
112FGFR10.45144779
113ACVR1B0.44928973
114PRKD10.44873724
115TAOK10.44274417
116TEC0.44141243
117MAPK110.43878813
118PDPK10.42124543
119STK240.41579878
120MAPK10.41011089
121PRKAA10.40773943
122GSK3B0.39538128
123MAPK80.39367466
124MTOR0.38790794
125MST1R0.36003031
126BRSK20.33618806
127MAPK30.33483315
128IKBKE0.32133779
129BMPR1B0.29751983
130ATM0.28427246
131PINK10.28232896
132MAPK140.28096581
133WNK40.27161684
134ZAP700.26326477

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.25285050
2Circadian entrainment_Homo sapiens_hsa047132.02969341
3Long-term potentiation_Homo sapiens_hsa047201.96578256
4Glutamatergic synapse_Homo sapiens_hsa047241.80743097
5Morphine addiction_Homo sapiens_hsa050321.79475022
6Insulin secretion_Homo sapiens_hsa049111.78658678
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.78390666
8Amphetamine addiction_Homo sapiens_hsa050311.72364996
9Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67852853
10Olfactory transduction_Homo sapiens_hsa047401.67310927
11GABAergic synapse_Homo sapiens_hsa047271.65336232
12Salivary secretion_Homo sapiens_hsa049701.64166902
13Type II diabetes mellitus_Homo sapiens_hsa049301.61410212
14Renin secretion_Homo sapiens_hsa049241.56907054
15Acute myeloid leukemia_Homo sapiens_hsa052211.51910029
16Cholinergic synapse_Homo sapiens_hsa047251.50075764
17Gastric acid secretion_Homo sapiens_hsa049711.48361407
18Phototransduction_Homo sapiens_hsa047441.43044008
19Dopaminergic synapse_Homo sapiens_hsa047281.42709009
20Phosphatidylinositol signaling system_Homo sapiens_hsa040701.40292287
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36648316
22Oxytocin signaling pathway_Homo sapiens_hsa049211.36438953
23Calcium signaling pathway_Homo sapiens_hsa040201.35527432
24cAMP signaling pathway_Homo sapiens_hsa040241.33114347
25Long-term depression_Homo sapiens_hsa047301.28575429
26Cocaine addiction_Homo sapiens_hsa050301.28419094
27cGMP-PKG signaling pathway_Homo sapiens_hsa040221.27878123
28Dilated cardiomyopathy_Homo sapiens_hsa054141.27207431
29Taste transduction_Homo sapiens_hsa047421.25471005
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.25322697
31Glioma_Homo sapiens_hsa052141.17717050
32GnRH signaling pathway_Homo sapiens_hsa049121.17359064
33Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.17031981
34Synaptic vesicle cycle_Homo sapiens_hsa047211.16911602
35Serotonergic synapse_Homo sapiens_hsa047261.13184473
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09164925
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08497331
38Dorso-ventral axis formation_Homo sapiens_hsa043201.06496990
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05845738
40ABC transporters_Homo sapiens_hsa020101.04901041
41Estrogen signaling pathway_Homo sapiens_hsa049151.03109390
42ErbB signaling pathway_Homo sapiens_hsa040121.01731762
43TGF-beta signaling pathway_Homo sapiens_hsa043501.00257452
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99853057
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.99379640
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.99265574
47Circadian rhythm_Homo sapiens_hsa047100.97553221
48Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97305545
49Axon guidance_Homo sapiens_hsa043600.96977217
50Pancreatic secretion_Homo sapiens_hsa049720.96414641
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94162894
52AMPK signaling pathway_Homo sapiens_hsa041520.94046352
53Melanogenesis_Homo sapiens_hsa049160.93249772
54Adherens junction_Homo sapiens_hsa045200.88975282
55Gap junction_Homo sapiens_hsa045400.86796871
56MAPK signaling pathway_Homo sapiens_hsa040100.86378158
57Choline metabolism in cancer_Homo sapiens_hsa052310.85727928
58Thyroid hormone synthesis_Homo sapiens_hsa049180.85547581
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.82495859
60Inositol phosphate metabolism_Homo sapiens_hsa005620.81888387
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78956827
62Colorectal cancer_Homo sapiens_hsa052100.78652648
63Focal adhesion_Homo sapiens_hsa045100.78440740
64Rap1 signaling pathway_Homo sapiens_hsa040150.78290967
65Endometrial cancer_Homo sapiens_hsa052130.78016392
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.77873228
67B cell receptor signaling pathway_Homo sapiens_hsa046620.77687866
68mTOR signaling pathway_Homo sapiens_hsa041500.75792906
69* Lysine degradation_Homo sapiens_hsa003100.75382535
70Thyroid cancer_Homo sapiens_hsa052160.75299335
71ECM-receptor interaction_Homo sapiens_hsa045120.74695651
72Glucagon signaling pathway_Homo sapiens_hsa049220.74643766
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73647987
74Platelet activation_Homo sapiens_hsa046110.73398740
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72964552
76Wnt signaling pathway_Homo sapiens_hsa043100.72446937
77Osteoclast differentiation_Homo sapiens_hsa043800.71135766
78* Tight junction_Homo sapiens_hsa045300.70824294
79MicroRNAs in cancer_Homo sapiens_hsa052060.69664984
80Non-small cell lung cancer_Homo sapiens_hsa052230.69388364
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69043798
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68990295
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.68871884
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68442166
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.68290698
86Proteoglycans in cancer_Homo sapiens_hsa052050.67505793
87Fatty acid biosynthesis_Homo sapiens_hsa000610.66864492
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66359682
89Regulation of autophagy_Homo sapiens_hsa041400.65247525
90Chemokine signaling pathway_Homo sapiens_hsa040620.64959668
91Insulin resistance_Homo sapiens_hsa049310.64516115
92Ras signaling pathway_Homo sapiens_hsa040140.64455537
93Prostate cancer_Homo sapiens_hsa052150.64172722
94Nitrogen metabolism_Homo sapiens_hsa009100.63757934
95TNF signaling pathway_Homo sapiens_hsa046680.62768129
96Ovarian steroidogenesis_Homo sapiens_hsa049130.62462060
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62014562
98African trypanosomiasis_Homo sapiens_hsa051430.61759753
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61605040
100FoxO signaling pathway_Homo sapiens_hsa040680.61591238
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61550127
102Prolactin signaling pathway_Homo sapiens_hsa049170.61224216
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60570500
104T cell receptor signaling pathway_Homo sapiens_hsa046600.59826264
105Pancreatic cancer_Homo sapiens_hsa052120.57291032
106Bile secretion_Homo sapiens_hsa049760.57206531
107Chronic myeloid leukemia_Homo sapiens_hsa052200.56900821
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56865609
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56359252
110Histidine metabolism_Homo sapiens_hsa003400.56262803
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51745649
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51505539
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.51203487
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51159966
115VEGF signaling pathway_Homo sapiens_hsa043700.50982106
116Insulin signaling pathway_Homo sapiens_hsa049100.50371181
117Type I diabetes mellitus_Homo sapiens_hsa049400.49789469
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48965777
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48327187
120Renal cell carcinoma_Homo sapiens_hsa052110.48134625

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