ASGR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.57091777
2L-phenylalanine catabolic process (GO:0006559)7.57091777
3L-phenylalanine metabolic process (GO:0006558)7.25214069
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.25214069
5aromatic amino acid family catabolic process (GO:0009074)6.84535926
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.45758126
7tryptophan catabolic process (GO:0006569)6.21135513
8indole-containing compound catabolic process (GO:0042436)6.21135513
9indolalkylamine catabolic process (GO:0046218)6.21135513
10kynurenine metabolic process (GO:0070189)6.07430989
11regulation of plasminogen activation (GO:0010755)5.98414296
12bile acid biosynthetic process (GO:0006699)5.96799728
13tryptophan metabolic process (GO:0006568)5.84341034
14glyoxylate metabolic process (GO:0046487)5.74988851
15high-density lipoprotein particle remodeling (GO:0034375)5.72154964
16negative regulation of fibrinolysis (GO:0051918)5.71135214
17urea cycle (GO:0000050)5.70306723
18urea metabolic process (GO:0019627)5.70306723
19alpha-linolenic acid metabolic process (GO:0036109)5.54303330
20regulation of fibrinolysis (GO:0051917)5.49436241
21peptidyl-glutamic acid carboxylation (GO:0017187)5.46373309
22protein carboxylation (GO:0018214)5.46373309
23complement activation, alternative pathway (GO:0006957)5.36774213
24regulation of protein activation cascade (GO:2000257)5.35464886
25epoxygenase P450 pathway (GO:0019373)5.35218738
26sulfur amino acid catabolic process (GO:0000098)5.33015079
27cysteine metabolic process (GO:0006534)5.31681066
28intestinal cholesterol absorption (GO:0030299)5.30825345
29nitrogen cycle metabolic process (GO:0071941)5.24218989
30serine family amino acid catabolic process (GO:0009071)5.14093508
31bile acid metabolic process (GO:0008206)5.10333148
32regulation of cholesterol esterification (GO:0010872)5.07545451
33acute-phase response (GO:0006953)5.05535437
34exogenous drug catabolic process (GO:0042738)5.02462257
35regulation of complement activation (GO:0030449)4.99178485
36aromatic amino acid family metabolic process (GO:0009072)4.98083536
37negative regulation of protein activation cascade (GO:2000258)4.95995452
38regulation of apoptotic cell clearance (GO:2000425)4.95858140
39reverse cholesterol transport (GO:0043691)4.94502980
40macromolecular complex remodeling (GO:0034367)4.88232539
41plasma lipoprotein particle remodeling (GO:0034369)4.88232539
42protein-lipid complex remodeling (GO:0034368)4.88232539
43regulation of triglyceride catabolic process (GO:0010896)4.86978740
44fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.85949211
45protein-lipid complex subunit organization (GO:0071825)4.83936455
46tyrosine metabolic process (GO:0006570)4.81369097
47regulation of humoral immune response (GO:0002920)4.81289435
48negative regulation of blood coagulation (GO:0030195)4.78292335
49negative regulation of hemostasis (GO:1900047)4.78292335
50phospholipid efflux (GO:0033700)4.72078758
51omega-hydroxylase P450 pathway (GO:0097267)4.72012229
52homocysteine metabolic process (GO:0050667)4.70921134
53negative regulation of sterol transport (GO:0032372)4.69441955
54negative regulation of cholesterol transport (GO:0032375)4.69441955
55positive regulation of hemostasis (GO:1900048)4.67639815
56positive regulation of blood coagulation (GO:0030194)4.67639815
57alpha-amino acid catabolic process (GO:1901606)4.63847427
58triglyceride homeostasis (GO:0070328)4.63689137
59acylglycerol homeostasis (GO:0055090)4.63689137
60amino-acid betaine metabolic process (GO:0006577)4.57198411
61lysine catabolic process (GO:0006554)4.54405846
62lysine metabolic process (GO:0006553)4.54405846
63plasma lipoprotein particle clearance (GO:0034381)4.49599494
64cellular ketone body metabolic process (GO:0046950)4.43262340
65glycine metabolic process (GO:0006544)4.42375684
66indolalkylamine metabolic process (GO:0006586)4.39912207
67bile acid and bile salt transport (GO:0015721)4.39695612
68coenzyme catabolic process (GO:0009109)4.37976034
69negative regulation of coagulation (GO:0050819)4.36994119
70imidazole-containing compound metabolic process (GO:0052803)4.35378582
71cholesterol efflux (GO:0033344)4.31782139
72amine catabolic process (GO:0009310)4.31399713
73cellular biogenic amine catabolic process (GO:0042402)4.31399713
74positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.30475822
75positive regulation of coagulation (GO:0050820)4.28361479
76cellular amino acid catabolic process (GO:0009063)4.25851870
77positive regulation of fatty acid biosynthetic process (GO:0045723)4.25823694
78cellular glucuronidation (GO:0052695)4.24292339
79negative regulation of wound healing (GO:0061045)4.22773115
80glutamate metabolic process (GO:0006536)4.21354586
81serine family amino acid metabolic process (GO:0009069)4.16490012
82benzene-containing compound metabolic process (GO:0042537)4.15958102
83plasma lipoprotein particle assembly (GO:0034377)4.09947700
84low-density lipoprotein particle remodeling (GO:0034374)4.09514724
85negative regulation of complement activation (GO:0045916)4.06865328
86fibrinolysis (GO:0042730)4.06817524
87ethanol oxidation (GO:0006069)4.06502186
88arginine metabolic process (GO:0006525)4.05030298
89dicarboxylic acid biosynthetic process (GO:0043650)4.02782435
90cellular modified amino acid catabolic process (GO:0042219)4.02775116
91aldehyde catabolic process (GO:0046185)4.00947223
92serine family amino acid biosynthetic process (GO:0009070)4.00126504
93ethanol metabolic process (GO:0006067)3.99618248
94drug catabolic process (GO:0042737)3.95288692
95blood coagulation, intrinsic pathway (GO:0007597)3.89633222
96very-low-density lipoprotein particle assembly (GO:0034379)3.85363668
97ketone body metabolic process (GO:1902224)3.83507831
98cofactor catabolic process (GO:0051187)3.82439635
99positive regulation of lipoprotein lipase activity (GO:0051006)3.82435330
100positive regulation of triglyceride lipase activity (GO:0061365)3.82435330
101lipoprotein metabolic process (GO:0042157)3.82310576
102negative regulation of lipase activity (GO:0060192)3.81950465
103acute inflammatory response (GO:0002526)3.81880770
104complement activation, classical pathway (GO:0006958)3.80046751
105positive regulation of lipid catabolic process (GO:0050996)3.78697863
106glucuronate metabolic process (GO:0019585)3.76350521
107uronic acid metabolic process (GO:0006063)3.76350521
108proline metabolic process (GO:0006560)3.76274380
109cholesterol homeostasis (GO:0042632)3.75547647
110complement activation (GO:0006956)3.75477283
111protein activation cascade (GO:0072376)3.75048327
112regulation of bile acid biosynthetic process (GO:0070857)3.71704841
113organic acid catabolic process (GO:0016054)3.71634265
114carboxylic acid catabolic process (GO:0046395)3.71634265
115phospholipid homeostasis (GO:0055091)3.71251654
116plasma lipoprotein particle organization (GO:0071827)3.70440978
117sterol homeostasis (GO:0055092)3.69318585
118drug metabolic process (GO:0017144)3.68748382
119protein-lipid complex assembly (GO:0065005)3.68226433
120cytolysis (GO:0019835)3.66069658
121sterol transport (GO:0015918)3.64839875
122cholesterol transport (GO:0030301)3.64839875
123short-chain fatty acid metabolic process (GO:0046459)3.64540519
124acetyl-CoA metabolic process (GO:0006084)3.63241259
125regulation of cholesterol homeostasis (GO:2000188)3.61210873
126heme transport (GO:0015886)3.61012922
127NAD biosynthetic process (GO:0009435)3.60741785
128positive regulation of extracellular matrix organization (GO:1903055)3.58572705
129disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.53244777
130killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.53244777
131regulation of lipoprotein particle clearance (GO:0010984)3.48167939
132phenylpropanoid metabolic process (GO:0009698)3.47084510
133opsonization (GO:0008228)3.44938466
134regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.41550082
135oxidative demethylation (GO:0070989)3.36898143
136positive regulation of steroid metabolic process (GO:0045940)3.36714828
137regulation of acute inflammatory response (GO:0002673)3.33455423
138intestinal absorption (GO:0050892)3.32726371

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.40817470
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.21245664
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.11001443
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.51959100
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.32208616
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.17963136
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.88475223
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.06226420
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.04092637
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.06514670
11* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9416723
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98744952
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97460482
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.91345171
15FOXA2_19822575_ChIP-Seq_HepG2_Human1.60241201
16CLOCK_20551151_ChIP-Seq_293T_Human1.51534622
17* HTT_18923047_ChIP-ChIP_STHdh_Human1.45929126
18* HNF4A_19822575_ChIP-Seq_HepG2_Human1.39987625
19GATA1_22025678_ChIP-Seq_K562_Human1.37786686
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22051704
21RXRA_24833708_ChIP-Seq_LIVER_Mouse1.21767421
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21426656
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08699536
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07954189
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06281810
26ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01966138
27* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01787274
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01412931
29TCF4_18268006_ChIP-ChIP_LS174T_Human0.99000316
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97332198
31IRF8_22096565_ChIP-ChIP_GC-B_Human0.95307467
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94636178
33TRIM28_21343339_ChIP-Seq_HEK293_Human0.94103351
34TP63_17297297_ChIP-ChIP_HaCaT_Human0.91652659
35* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90682216
36SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90482363
37* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89982888
38* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88226567
39PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85185899
40AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84316042
41DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83937892
42KAP1_22055183_ChIP-Seq_ESCs_Mouse0.83854650
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.82943869
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82795037
45RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82493750
46GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.80344684
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80036806
48GATA4_25053715_ChIP-Seq_YYC3_Human0.79549059
49POU5F1_16518401_ChIP-PET_MESCs_Mouse0.78090571
50SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77984211
51ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77329080
52SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77224940
53SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75324129
54RARA_24833708_ChIP-Seq_LIVER_Mouse0.75131612
55* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.73878997
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73368882
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72639849
58SMC4_20622854_ChIP-Seq_HELA_Human0.72011249
59ZNF263_19887448_ChIP-Seq_K562_Human0.71798147
60* RAC3_21632823_ChIP-Seq_H3396_Human0.71476503
61BRD4_27068464_Chip-Seq_AML-cells_Mouse0.70243382
62FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.68309924
63NFIB_24661679_ChIP-Seq_LUNG_Mouse0.68165528
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.68016216
65SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67810160
66ELF1_20517297_ChIP-Seq_JURKAT_Human0.67029665
67GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.66773982
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.66723608
69SOX2_20726797_ChIP-Seq_SW620_Human0.66334312
70AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65473373
71SPI1_20517297_ChIP-Seq_HL60_Human0.65128114
72ESR2_21235772_ChIP-Seq_MCF-7_Human0.64523527
73SOX2_21211035_ChIP-Seq_LN229_Human0.64233048
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.64172720
75NRF2_20460467_ChIP-Seq_MEFs_Mouse0.63666994
76NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.63666994
77TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.62490383
78* RARB_24833708_ChIP-Seq_LIVER_Mouse0.62107724
79E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.62103785
80GATA1_22383799_ChIP-Seq_G1ME_Mouse0.61960440
81BCOR_27268052_Chip-Seq_Bcells_Human0.61809498
82BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61548475
83RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61538574
84CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.61262877
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60695669
86PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.60626811
87HIF1A_21447827_ChIP-Seq_MCF-7_Human0.60443948
88JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.58935949
89CEBPB_22108803_ChIP-Seq_LS180_Human0.58095890
90E2F1_20622854_ChIP-Seq_HELA_Human0.57241443
91CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.57105571
92P68_20966046_ChIP-Seq_HELA_Human0.57064520
93CSB_26484114_Chip-Seq_FIBROBLAST_Human0.56841215
94RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.54934014
95* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.54870880
96EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.54160279
97NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.54027833
98STAT3_1855785_ChIP-Seq_MESCs_Mouse0.53607791
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52971169
100EGR1_19032775_ChIP-ChIP_M12_Human0.52610036
101LXR_22292898_ChIP-Seq_THP-1_Human0.51987759
102FOXA1_25552417_ChIP-Seq_VCAP_Human0.51930705
103AR_20517297_ChIP-Seq_VCAP_Human0.51547077
104FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50271219
105FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50122229
106ESET_19884257_ChIP-Seq_ESCs_Mouse0.49666538
107STAT1_17558387_ChIP-Seq_HELA_Human0.49088832
108* MYC_19915707_ChIP-ChIP_AK7_Human0.48331682
109CBP_21632823_ChIP-Seq_H3396_Human0.47103212
110PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46579272
111P53_21459846_ChIP-Seq_SAOS-2_Human0.46511182
112PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43590998
113GATA1_19941827_ChIP-Seq_MEL_Mouse0.43259363
114PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42862946
115ESR1_21235772_ChIP-Seq_MCF-7_Human0.42519727
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.41560243
117CDX2_20551321_ChIP-Seq_CACO-2_Human0.41031943
118FOXO3_23340844_ChIP-Seq_DLD1_Human0.40898751
119TAF15_26573619_Chip-Seq_HEK293_Human0.40738722
120GATA1_19941826_ChIP-Seq_K562_Human0.40669747
121SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40474523
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39285758
123GATA2_19941826_ChIP-Seq_K562_Human0.39022715
124* TAF2_19829295_ChIP-Seq_ESCs_Human0.38974390
125STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38866727
126GATA6_25053715_ChIP-Seq_YYC3_Human0.38844941
127PPAR_26484153_Chip-Seq_NCI-H1993_Human0.38202549
128BCAT_22108803_ChIP-Seq_LS180_Human0.37841667
129MYC_27129775_Chip-Seq_CORNEA_Mouse0.37533405
130CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.36445057
131ERG_21242973_ChIP-ChIP_JURKAT_Human0.36039328
132ESR1_20079471_ChIP-ChIP_T-47D_Human0.35944535
133SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.35296579
134FOXH1_21741376_ChIP-Seq_EPCs_Human0.35020094
135* SPI1_26923725_Chip-Seq_HPCs_Mouse0.34825369
136* LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.33938243
137OCT4_20526341_ChIP-Seq_ESCs_Human0.33176522
138CDX2_22108803_ChIP-Seq_LS180_Human0.32851398
139SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.32544343
140ERG_20517297_ChIP-Seq_VCAP_Human0.32468378

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.38498222
2MP0005360_urolithiasis7.55076150
3MP0005085_abnormal_gallbladder_physiolo6.44137447
4MP0005365_abnormal_bile_salt6.20815986
5MP0008875_abnormal_xenobiotic_pharmacok5.12415866
6MP0003806_abnormal_nucleotide_metabolis4.26193617
7MP0003252_abnormal_bile_duct3.87999480
8MP0010329_abnormal_lipoprotein_level3.60574694
9MP0009840_abnormal_foam_cell3.39414575
10MP0005083_abnormal_biliary_tract3.03235664
11MP0003195_calcinosis2.85661791
12MP0005332_abnormal_amino_acid2.75443441
13MP0001666_abnormal_nutrient_absorption2.58314693
14MP0003122_maternal_imprinting2.46130953
15MP0003191_abnormal_cellular_cholesterol2.34581828
16MP0000609_abnormal_liver_physiology2.17016415
17MP0004019_abnormal_vitamin_homeostasis2.10764206
18* MP0002118_abnormal_lipid_homeostasis2.07011964
19MP0002138_abnormal_hepatobiliary_system1.98187841
20MP0003868_abnormal_feces_composition1.89085292
21MP0005319_abnormal_enzyme/_coenzyme1.82938050
22MP0003172_abnormal_lysosome_physiology1.64636243
23MP0009697_abnormal_copulation1.64135458
24MP0005584_abnormal_enzyme/coenzyme_acti1.55892864
25MP0001915_intracranial_hemorrhage1.55537883
26MP0005451_abnormal_body_composition1.47993658
27* MP0001764_abnormal_homeostasis1.42963886
28MP0000566_synostosis1.42421744
29MP0003011_delayed_dark_adaptation1.37880894
30MP0002089_abnormal_postnatal_growth/wei1.34096374
31MP0003656_abnormal_erythrocyte_physiolo1.28241611
32MP0003186_abnormal_redox_activity1.27908205
33MP0009643_abnormal_urine_homeostasis1.22532078
34MP0000598_abnormal_liver_morphology1.17769747
35MP0005647_abnormal_sex_gland1.15547606
36MP0003705_abnormal_hypodermis_morpholog1.15272946
37MP0000604_amyloidosis1.12139116
38MP0009764_decreased_sensitivity_to1.09019481
39MP0003123_paternal_imprinting1.05823629
40MP0002254_reproductive_system_inflammat1.01608176
41* MP0009763_increased_sensitivity_to0.98980072
42MP0010368_abnormal_lymphatic_system0.95646338
43MP0005636_abnormal_mineral_homeostasis0.93222470
44MP0008469_abnormal_protein_level0.91849736
45* MP0009642_abnormal_blood_homeostasis0.86658808
46MP0005408_hypopigmentation0.86255544
47MP0005167_abnormal_blood-brain_barrier0.84069381
48MP0006036_abnormal_mitochondrial_physio0.81444915
49MP0009765_abnormal_xenobiotic_induced0.78423409
50MP0003879_abnormal_hair_cell0.77473331
51MP0002078_abnormal_glucose_homeostasis0.76651747
52MP0005670_abnormal_white_adipose0.76617513
53MP0005084_abnormal_gallbladder_morpholo0.75911512
54MP0002876_abnormal_thyroid_physiology0.75696481
55* MP0005376_homeostasis/metabolism_phenot0.73523698
56MP0002971_abnormal_brown_adipose0.72056090
57MP0003690_abnormal_glial_cell0.70873864
58MP0005220_abnormal_exocrine_pancreas0.69753161
59MP0009785_altered_susceptibility_to0.68873295
60MP0005334_abnormal_fat_pad0.68629253
61MP0004130_abnormal_muscle_cell0.67363462
62MP0009053_abnormal_anal_canal0.67140084
63MP0001661_extended_life_span0.66054289
64MP0003329_amyloid_beta_deposits0.65881779
65MP0005535_abnormal_body_temperature0.65743415
66MP0005409_darkened_coat_color0.64911522
67MP0005266_abnormal_metabolism0.64330604
68MP0000639_abnormal_adrenal_gland0.61913346
69MP0003183_abnormal_peptide_metabolism0.61320944
70MP0000858_altered_metastatic_potential0.60205888
71MP0001756_abnormal_urination0.58008446
72MP0005464_abnormal_platelet_physiology0.57079215
73MP0006054_spinal_hemorrhage0.56114164
74MP0005377_hearing/vestibular/ear_phenot0.54679327
75MP0003878_abnormal_ear_physiology0.54679327
76MP0006035_abnormal_mitochondrial_morpho0.54417369
77MP0005448_abnormal_energy_balance0.54106770
78MP0003718_maternal_effect0.52776087
79MP0005395_other_phenotype0.51522869
80MP0002282_abnormal_trachea_morphology0.51439252
81MP0008260_abnormal_autophagy0.49843195
82MP0002933_joint_inflammation0.49397136
83MP0002419_abnormal_innate_immunity0.49027427
84MP0000920_abnormal_myelination0.48595303
85MP0000685_abnormal_immune_system0.47745721
86MP0002822_catalepsy0.47450239
87MP0003436_decreased_susceptibility_to0.47355125
88MP0008874_decreased_physiological_sensi0.46536309
89MP0003638_abnormal_response/metabolism_0.45806917
90MP0008873_increased_physiological_sensi0.45438457
91MP0002136_abnormal_kidney_physiology0.45184419
92MP0004782_abnormal_surfactant_physiolog0.44698038
93MP0005023_abnormal_wound_healing0.44441038
94MP0003724_increased_susceptibility_to0.43688028
95MP0002928_abnormal_bile_duct0.43082622
96MP0003075_altered_response_to0.42801208
97MP0004272_abnormal_basement_membrane0.41132833
98MP0005248_abnormal_Harderian_gland0.40726290
99MP0005166_decreased_susceptibility_to0.40444651
100MP0003567_abnormal_fetal_cardiomyocyte0.40088089
101MP0003953_abnormal_hormone_level0.39760284
102MP0009333_abnormal_splenocyte_physiolog0.38955973
103MP0003632_abnormal_nervous_system0.38699955
104* MP0005025_abnormal_response_to0.38390610
105MP0003303_peritoneal_inflammation0.38294691
106MP0002837_dystrophic_cardiac_calcinosis0.38228768
107MP0006082_CNS_inflammation0.37655639
108MP0004381_abnormal_hair_follicle0.37566315
109MP0008872_abnormal_physiological_respon0.36984563
110MP0003121_genomic_imprinting0.36927663
111MP0003566_abnormal_cell_adhesion0.36074952
112MP0000579_abnormal_nail_morphology0.35569094
113MP0005257_abnormal_intraocular_pressure0.35426478
114MP0009672_abnormal_birth_weight0.35421103
115MP0001533_abnormal_skeleton_physiology0.35127655
116MP0003943_abnormal_hepatobiliary_system0.35003160
117MP0005666_abnormal_adipose_tissue0.34676783
118MP0005076_abnormal_cell_differentiation0.34516711
119MP0004264_abnormal_extraembryonic_tissu0.34330396
120MP0000249_abnormal_blood_vessel0.33626547
121MP0009115_abnormal_fat_cell0.33585616
122MP0004883_abnormal_blood_vessel0.32995910
123MP0001324_abnormal_eye_pigmentation0.32632884
124MP0001853_heart_inflammation0.31966518
125MP0001243_abnormal_dermal_layer0.31488234
126MP0002168_other_aberrant_phenotype0.31245247
127MP0002796_impaired_skin_barrier0.30702781
128MP0001845_abnormal_inflammatory_respons0.30312248
129MP0002970_abnormal_white_adipose0.29976080
130MP0001881_abnormal_mammary_gland0.29361201
131MP0000230_abnormal_systemic_arterial0.29140412
132MP0009384_cardiac_valve_regurgitation0.27079755
133MP0002132_abnormal_respiratory_system0.26385227
134MP0005164_abnormal_response_to0.26107290
135MP0005058_abnormal_lysosome_morphology0.26096890
136MP0002090_abnormal_vision0.22637745

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.49396359
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.42457294
3Intrahepatic cholestasis (HP:0001406)7.31157435
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.70842479
5Prolonged partial thromboplastin time (HP:0003645)6.66313284
6Hypobetalipoproteinemia (HP:0003563)6.46950819
7Xanthomatosis (HP:0000991)6.29183211
8Hyperlipoproteinemia (HP:0010980)5.62916282
9Complement deficiency (HP:0004431)5.41939278
10Joint hemorrhage (HP:0005261)4.90722117
11Hypolipoproteinemia (HP:0010981)4.84214838
12Hyperammonemia (HP:0001987)4.59372267
13Abnormality of the common coagulation pathway (HP:0010990)4.49793622
14Epidermoid cyst (HP:0200040)4.47127599
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.42350758
16Hyperglycinemia (HP:0002154)4.41910566
17Abnormality of methionine metabolism (HP:0010901)4.28519644
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.24468220
19Hypoalphalipoproteinemia (HP:0003233)4.23352955
20Ketosis (HP:0001946)4.22260312
21Fat malabsorption (HP:0002630)4.13953492
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.09167348
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.08692667
24Abnormality of complement system (HP:0005339)3.96687364
25Hyperglycinuria (HP:0003108)3.89816981
26Abnormality of pyrimidine metabolism (HP:0004353)3.88542695
27Abnormality of glycine metabolism (HP:0010895)3.88216545
28Abnormality of serine family amino acid metabolism (HP:0010894)3.88216545
29Hypoglycemic coma (HP:0001325)3.85950092
30Abnormality of the intrinsic pathway (HP:0010989)3.79826324
31Conjugated hyperbilirubinemia (HP:0002908)3.69081447
32Hypercholesterolemia (HP:0003124)3.65496390
33Purpura (HP:0000979)3.51481147
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.34882891
35Hyperbilirubinemia (HP:0002904)3.32820921
36Abnormality of fatty-acid metabolism (HP:0004359)3.31610779
37Steatorrhea (HP:0002570)3.14882328
38Spontaneous abortion (HP:0005268)3.10160995
39Delayed CNS myelination (HP:0002188)3.07731176
40Abnormality of nucleobase metabolism (HP:0010932)3.06703848
41Abnormality of serum amino acid levels (HP:0003112)3.06021116
42Myocardial infarction (HP:0001658)3.01723995
43Hypochromic microcytic anemia (HP:0004840)3.01590146
44Ketoacidosis (HP:0001993)2.97609180
45Hepatocellular carcinoma (HP:0001402)2.96191862
46Systemic lupus erythematosus (HP:0002725)2.81329968
47Skin nodule (HP:0200036)2.75953543
48Metabolic acidosis (HP:0001942)2.73519347
49Abnormality of purine metabolism (HP:0004352)2.65784425
50Vascular calcification (HP:0004934)2.60712653
51Lethargy (HP:0001254)2.59863579
52Pulmonary embolism (HP:0002204)2.55369292
53Dicarboxylic aciduria (HP:0003215)2.54483279
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.54483279
55Glomerulonephritis (HP:0000099)2.52814038
56Acanthocytosis (HP:0001927)2.52479436
57Recurrent gram-negative bacterial infections (HP:0005420)2.47902072
58Hypoglycemic seizures (HP:0002173)2.47844152
59Osteomalacia (HP:0002749)2.46921288
60Abnormal gallbladder morphology (HP:0012437)2.46381992
61Mitral stenosis (HP:0001718)2.44988475
62Spastic diplegia (HP:0001264)2.44079675
63Abnormality of carpal bone ossification (HP:0006257)2.41112130
64Cerebral edema (HP:0002181)2.40747153
65Cholelithiasis (HP:0001081)2.40732335
66Gout (HP:0001997)2.38205636
67Amyloidosis (HP:0011034)2.36083727
68Irritability (HP:0000737)2.35266725
69Neonatal onset (HP:0003623)2.34187954
70Abnormal gallbladder physiology (HP:0012438)2.33334297
71Cholecystitis (HP:0001082)2.33334297
72Abnormal tarsal ossification (HP:0008369)2.31985613
73Cardiovascular calcification (HP:0011915)2.30801380
74Gingival bleeding (HP:0000225)2.28977426
75Arthropathy (HP:0003040)2.26905695
76Malnutrition (HP:0004395)2.25218438
77Esophageal varix (HP:0002040)2.22289211
78Menorrhagia (HP:0000132)2.19291305
79Epistaxis (HP:0000421)2.17470187
80Late onset (HP:0003584)2.15432154
81Pancreatitis (HP:0001733)2.13620754
82Brushfield spots (HP:0001088)2.13060656
83Thrombophlebitis (HP:0004418)2.12566920
84Sensorimotor neuropathy (HP:0007141)2.12292593
85Enlarged kidneys (HP:0000105)2.05902376
86Vomiting (HP:0002013)2.04865503
87Gangrene (HP:0100758)2.03825273
88Hemorrhage of the eye (HP:0011885)2.02929161
89Opisthotonus (HP:0002179)2.02682481
90Poikilocytosis (HP:0004447)2.01956063
91Generalized aminoaciduria (HP:0002909)2.00859978
92Abnormality of the Achilles tendon (HP:0005109)2.00531185
93Hyperinsulinemic hypoglycemia (HP:0000825)2.00354464
94Abnormality of the gallbladder (HP:0005264)1.99579866
95Abnormality of iron homeostasis (HP:0011031)1.99061642
96Potter facies (HP:0002009)1.97910012
97Facial shape deformation (HP:0011334)1.97910012
98Abnormality of transition element cation homeostasis (HP:0011030)1.94352663
99Increased serum ferritin (HP:0003281)1.93699558
100Rickets (HP:0002748)1.91933528
101Increased serum pyruvate (HP:0003542)1.91709493
102Joint swelling (HP:0001386)1.89333192
103Flat acetabular roof (HP:0003180)1.88934830
104Hypophosphatemic rickets (HP:0004912)1.87370192
105Abnormality of the lumbar spine (HP:0100712)1.86398519
106Abnormal cartilage morphology (HP:0002763)1.85234225
107Renal cortical cysts (HP:0000803)1.82311038
108Broad alveolar ridges (HP:0000187)1.81731760
109Abnormality of proline metabolism (HP:0010907)1.80994746
110Hydroxyprolinuria (HP:0003080)1.80994746
111Nephritis (HP:0000123)1.79776542
112Abnormal enzyme/coenzyme activity (HP:0012379)1.79646559
113Elevated hepatic transaminases (HP:0002910)1.79645310
114Pancreatic islet-cell hyperplasia (HP:0004510)1.78303223
115Status epilepticus (HP:0002133)1.77960131
116Alkalosis (HP:0001948)1.76852605
117Hyperglycemia (HP:0003074)1.76529290
118Abnormal ossification of hand bones (HP:0005921)1.75104933
119Abnormal hand bone ossification (HP:0010660)1.73603307
120Peritonitis (HP:0002586)1.73550216
121Urinary glycosaminoglycan excretion (HP:0003541)1.71539881
122Mucopolysacchariduria (HP:0008155)1.71539881
123Abnormality of vitamin metabolism (HP:0100508)1.70971615
124Small epiphyses (HP:0010585)1.70422497
125Vaginal fistula (HP:0004320)1.70207042
126Bifid scrotum (HP:0000048)1.69679126
127Abnormality of glycolysis (HP:0004366)1.68674528
128Hypochromic anemia (HP:0001931)1.68054734
129Widely patent fontanelles and sutures (HP:0004492)1.66366630
130Reduced antithrombin III activity (HP:0001976)1.65308540
131Gastrointestinal infarctions (HP:0005244)1.64555912
132Asymmetry of the thorax (HP:0001555)1.63501605
133Prolonged bleeding time (HP:0003010)1.56461097
134Retrobulbar optic neuritis (HP:0100654)1.56451682
135Optic neuritis (HP:0100653)1.56451682
136Abnormal delivery (HP:0001787)1.55996725
137Abnormality of mucopolysaccharide metabolism (HP:0011020)1.55935129
138Abnormality of glycosaminoglycan metabolism (HP:0004371)1.55935129

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.17188527
2FGFR44.67492999
3SIK14.56494317
4ERN14.35059734
5TAOK33.29219182
6ERBB42.98368895
7INSRR2.83128111
8CDK122.53268871
9MAP2K42.32747946
10WNK42.27784047
11PKN22.18044402
12MST1R2.06504489
13FLT31.89689104
14PIK3CG1.89190992
15MAPK111.87394501
16TYRO31.85763714
17TRIB31.81477470
18TYK21.80716953
19DAPK21.67152144
20FGFR11.66912640
21LATS11.66882272
22ABL21.56526094
23NEK91.45025590
24SIK21.44362281
25PTK61.43991560
26PDGFRA1.41544789
27FGR1.34036442
28JAK21.28241913
29KDR1.27915973
30FGFR21.25970770
31FRK1.24571254
32TBK11.15943912
33PINK11.12050389
34MAP3K21.10469442
35MAP3K71.10262742
36PRKAA21.09713223
37WNK11.09418275
38MAP3K141.06895566
39JAK11.05374008
40GRK61.04623497
41MAP2K31.04459494
42AKT31.01069291
43ERBB20.98126617
44MAPK40.96529939
45MAP3K100.93667800
46STK38L0.92075723
47PRKCZ0.91730469
48BLK0.88825547
49SMG10.88544111
50ZAP700.85860440
51MAP3K110.85542024
52CDK60.85404004
53EPHB10.84885501
54KSR20.84334532
55DDR20.84129012
56MATK0.82273472
57MAPK150.81114677
58MET0.81030637
59CDC42BPA0.80639457
60MAP3K30.79994149
61MAPK120.79146773
62EPHA30.77632779
63PRKACG0.75392688
64PRPF4B0.74965380
65EEF2K0.74962749
66CSK0.74374528
67TIE10.74221312
68RIPK40.74166060
69NTRK30.73955771
70DYRK1B0.73886640
71CAMK2G0.70827137
72IRAK30.67641695
73EIF2AK10.67454891
74MAP2K60.64979082
75CAMK1D0.64596073
76GSK3A0.64139474
77SGK10.63654543
78PRKAA10.63636593
79CDK70.62971841
80RIPK10.61581362
81IKBKE0.59547999
82CSF1R0.59018163
83SGK30.58698399
84MAP4K10.57996352
85TGFBR20.56186168
86FGFR30.54651421
87MAPK70.54517983
88PTK20.52834370
89PDPK10.52784699
90PRKCQ0.50937102
91MAP3K50.50454716
92MAP3K130.49225017
93CSNK1G10.48479765
94TAOK20.47948060
95MAP3K60.47707594
96EPHA40.46637858
97RPS6KB10.46055878
98MARK20.45381808
99CSNK1E0.45065358
100IGF1R0.43687772
101PBK0.42478092
102CDK40.42393053
103MAP2K10.42079041
104CAMKK20.41491001
105GRK10.41107183
106RET0.41089457
107SGK20.40451742
108YES10.40448486
109SRC0.39926303
110SYK0.39762318
111PRKCG0.38879363
112MAPKAPK30.37742395
113LCK0.37473558
114TAOK10.36465261
115PKN10.36068519
116PRKG10.35567631
117ICK0.35540979
118EGFR0.34626348
119LATS20.34119850
120MTOR0.33728430
121CSNK1D0.33630273
122ITK0.32839821
123TNK20.32705130
124PDK10.32468024
125LYN0.29972939
126CAMK40.29835362
127FYN0.28424507
128CSNK1G20.27913500
129MAP3K10.26894427
130CSNK1G30.26318723
131IRAK10.25886254
132SGK2230.25793083
133SGK4940.25793083
134PRKCA0.25493715
135IRAK20.25213012
136PIK3CA0.23642524
137ABL10.23611770
138BMX0.19964078
139MAP2K20.19169602
140STK30.18487586
141MAPK30.18338655

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.56682858
2Nitrogen metabolism_Homo sapiens_hsa009103.54774415
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.40678339
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.37110339
5Arginine biosynthesis_Homo sapiens_hsa002203.08434250
6Complement and coagulation cascades_Homo sapiens_hsa046102.81295567
7Tryptophan metabolism_Homo sapiens_hsa003802.69611982
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67259616
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62471543
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55774159
11Fatty acid degradation_Homo sapiens_hsa000712.45519387
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36725648
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.25686126
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.17903970
15Butanoate metabolism_Homo sapiens_hsa006502.12556917
16Peroxisome_Homo sapiens_hsa041462.07168117
17Chemical carcinogenesis_Homo sapiens_hsa052041.98884498
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.96700296
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.94510510
20Histidine metabolism_Homo sapiens_hsa003401.91531249
21Propanoate metabolism_Homo sapiens_hsa006401.89415712
22PPAR signaling pathway_Homo sapiens_hsa033201.85775974
23Staphylococcus aureus infection_Homo sapiens_hsa051501.81308279
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.79032797
25Fatty acid metabolism_Homo sapiens_hsa012121.77197839
26Caffeine metabolism_Homo sapiens_hsa002321.76690783
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74445548
28Retinol metabolism_Homo sapiens_hsa008301.72097490
29beta-Alanine metabolism_Homo sapiens_hsa004101.70222375
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66212493
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58585177
32Selenocompound metabolism_Homo sapiens_hsa004501.57201694
33Phenylalanine metabolism_Homo sapiens_hsa003601.56930375
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50623074
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49706932
36Bile secretion_Homo sapiens_hsa049761.48558515
37Tyrosine metabolism_Homo sapiens_hsa003501.45001203
38Pyruvate metabolism_Homo sapiens_hsa006201.33588814
39Sulfur metabolism_Homo sapiens_hsa009201.32853028
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.32347563
41Fatty acid elongation_Homo sapiens_hsa000621.30446115
42Starch and sucrose metabolism_Homo sapiens_hsa005001.27555958
43Folate biosynthesis_Homo sapiens_hsa007901.24021148
44Steroid biosynthesis_Homo sapiens_hsa001001.20777245
45Biosynthesis of amino acids_Homo sapiens_hsa012301.19565884
46ABC transporters_Homo sapiens_hsa020101.19426867
47Other glycan degradation_Homo sapiens_hsa005111.17617438
48Fat digestion and absorption_Homo sapiens_hsa049751.17070311
49Carbon metabolism_Homo sapiens_hsa012001.10632238
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01306941
51Vitamin B6 metabolism_Homo sapiens_hsa007501.00892396
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.00503314
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98389874
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.97302788
55Arginine and proline metabolism_Homo sapiens_hsa003300.96816260
56Sulfur relay system_Homo sapiens_hsa041220.95374077
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87422139
58Vitamin digestion and absorption_Homo sapiens_hsa049770.85167888
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80587051
60Lysine degradation_Homo sapiens_hsa003100.79525278
61One carbon pool by folate_Homo sapiens_hsa006700.76533051
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69068193
63Glutathione metabolism_Homo sapiens_hsa004800.66343406
64Glycerolipid metabolism_Homo sapiens_hsa005610.65657914
65Pentose phosphate pathway_Homo sapiens_hsa000300.56950951
66Fatty acid biosynthesis_Homo sapiens_hsa000610.50769093
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45987545
68Metabolic pathways_Homo sapiens_hsa011000.45485787
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43679053
70Prion diseases_Homo sapiens_hsa050200.37601025
71Galactose metabolism_Homo sapiens_hsa000520.25581300
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25415222
73Linoleic acid metabolism_Homo sapiens_hsa005910.23698869
74Fructose and mannose metabolism_Homo sapiens_hsa000510.22535892
75Insulin resistance_Homo sapiens_hsa049310.22426335
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.21174713
77N-Glycan biosynthesis_Homo sapiens_hsa005100.19223047
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18036428
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.15833115
80Mineral absorption_Homo sapiens_hsa049780.10525900
81Glucagon signaling pathway_Homo sapiens_hsa049220.08010125
82Sphingolipid metabolism_Homo sapiens_hsa006000.05346842
83AMPK signaling pathway_Homo sapiens_hsa041520.00985445
84Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2417219
85Bladder cancer_Homo sapiens_hsa05219-0.2410759
86Ether lipid metabolism_Homo sapiens_hsa00565-0.2410040
87Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2348277
88Pertussis_Homo sapiens_hsa05133-0.2340540
89Amoebiasis_Homo sapiens_hsa05146-0.2296069
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2045747
91Renin-angiotensin system_Homo sapiens_hsa04614-0.1897591
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1857637
93Leishmaniasis_Homo sapiens_hsa05140-0.1810905
94Hepatitis C_Homo sapiens_hsa05160-0.1768943
95Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1624062
96Other types of O-glycan biosynthesis_Homo sapiens_hsa00514-0.1620634
97Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1605250
98HIF-1 signaling pathway_Homo sapiens_hsa04066-0.1573094
99Non-small cell lung cancer_Homo sapiens_hsa05223-0.1567420
100Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1541578
101Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1449415
102Regulation of autophagy_Homo sapiens_hsa04140-0.1256703
103African trypanosomiasis_Homo sapiens_hsa05143-0.1154787
104Insulin signaling pathway_Homo sapiens_hsa04910-0.1104212
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1084453
106* Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0684217
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0681624
108Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0631524
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0439396
110Lysosome_Homo sapiens_hsa04142-0.0210619

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