ASGR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.62860924
2L-phenylalanine catabolic process (GO:0006559)7.62860924
3L-phenylalanine metabolic process (GO:0006558)7.29988149
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.29988149
5aromatic amino acid family catabolic process (GO:0009074)6.84636992
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.45712508
7tryptophan catabolic process (GO:0006569)6.16228909
8indole-containing compound catabolic process (GO:0042436)6.16228909
9indolalkylamine catabolic process (GO:0046218)6.16228909
10intestinal cholesterol absorption (GO:0030299)6.05539806
11kynurenine metabolic process (GO:0070189)6.03369357
12regulation of plasminogen activation (GO:0010755)5.97453076
13bile acid biosynthetic process (GO:0006699)5.96124609
14glyoxylate metabolic process (GO:0046487)5.80585342
15tryptophan metabolic process (GO:0006568)5.80255125
16urea cycle (GO:0000050)5.68790598
17urea metabolic process (GO:0019627)5.68790598
18high-density lipoprotein particle remodeling (GO:0034375)5.68622766
19negative regulation of fibrinolysis (GO:0051918)5.66447626
20alpha-linolenic acid metabolic process (GO:0036109)5.61385355
21regulation of fibrinolysis (GO:0051917)5.45401397
22peptidyl-glutamic acid carboxylation (GO:0017187)5.40743386
23protein carboxylation (GO:0018214)5.40743386
24sulfur amino acid catabolic process (GO:0000098)5.36349254
25cysteine metabolic process (GO:0006534)5.34480139
26complement activation, alternative pathway (GO:0006957)5.32484457
27regulation of protein activation cascade (GO:2000257)5.30380069
28nitrogen cycle metabolic process (GO:0071941)5.23172216
29serine family amino acid catabolic process (GO:0009071)5.13978918
30bile acid metabolic process (GO:0008206)5.09989890
31protein-lipid complex subunit organization (GO:0071825)5.03970573
32regulation of cholesterol esterification (GO:0010872)4.98892149
33aromatic amino acid family metabolic process (GO:0009072)4.97774714
34reverse cholesterol transport (GO:0043691)4.94400679
35regulation of complement activation (GO:0030449)4.94054619
36regulation of triglyceride catabolic process (GO:0010896)4.91668750
37regulation of apoptotic cell clearance (GO:2000425)4.90750940
38epoxygenase P450 pathway (GO:0019373)4.89169993
39protein-lipid complex remodeling (GO:0034368)4.85192890
40macromolecular complex remodeling (GO:0034367)4.85192890
41plasma lipoprotein particle remodeling (GO:0034369)4.85192890
42fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.84773414
43tyrosine metabolic process (GO:0006570)4.84654203
44negative regulation of protein activation cascade (GO:2000258)4.81218668
45exogenous drug catabolic process (GO:0042738)4.76996907
46homocysteine metabolic process (GO:0050667)4.73894866
47acute-phase response (GO:0006953)4.72644120
48phospholipid efflux (GO:0033700)4.67911233
49acylglycerol homeostasis (GO:0055090)4.66787006
50triglyceride homeostasis (GO:0070328)4.66787006
51negative regulation of sterol transport (GO:0032372)4.66399296
52negative regulation of cholesterol transport (GO:0032375)4.66399296
53alpha-amino acid catabolic process (GO:1901606)4.65228514
54amino-acid betaine metabolic process (GO:0006577)4.59439485
55lysine catabolic process (GO:0006554)4.55877421
56lysine metabolic process (GO:0006553)4.55877421
57negative regulation of hemostasis (GO:1900047)4.53456396
58negative regulation of blood coagulation (GO:0030195)4.53456396
59cellular ketone body metabolic process (GO:0046950)4.48096527
60regulation of humoral immune response (GO:0002920)4.43714984
61plasma lipoprotein particle clearance (GO:0034381)4.43513891
62glycine metabolic process (GO:0006544)4.42484790
63coenzyme catabolic process (GO:0009109)4.41213866
64bile acid and bile salt transport (GO:0015721)4.39445346
65indolalkylamine metabolic process (GO:0006586)4.36808734
66imidazole-containing compound metabolic process (GO:0052803)4.35589223
67cellular biogenic amine catabolic process (GO:0042402)4.27812008
68amine catabolic process (GO:0009310)4.27812008
69cholesterol efflux (GO:0033344)4.27502657
70cellular amino acid catabolic process (GO:0009063)4.27473629
71positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.27269271
72positive regulation of hemostasis (GO:1900048)4.26789432
73positive regulation of blood coagulation (GO:0030194)4.26789432
74cellular glucuronidation (GO:0052695)4.25446521
75glutamate metabolic process (GO:0006536)4.24424605
76omega-hydroxylase P450 pathway (GO:0097267)4.22069490
77serine family amino acid metabolic process (GO:0009069)4.17167442
78negative regulation of coagulation (GO:0050819)4.14247811
79benzene-containing compound metabolic process (GO:0042537)4.13421620
80positive regulation of fatty acid biosynthetic process (GO:0045723)4.13359343
81ethanol oxidation (GO:0006069)4.07456153
82arginine metabolic process (GO:0006525)4.06242754
83cellular modified amino acid catabolic process (GO:0042219)4.05057690
84plasma lipoprotein particle assembly (GO:0034377)4.04286221
85proline metabolic process (GO:0006560)4.04230403
86low-density lipoprotein particle remodeling (GO:0034374)4.03893983
87fibrinolysis (GO:0042730)4.03603064
88aldehyde catabolic process (GO:0046185)4.03192330
89dicarboxylic acid biosynthetic process (GO:0043650)4.02943728
90serine family amino acid biosynthetic process (GO:0009070)4.00768517
91negative regulation of wound healing (GO:0061045)3.99382153
92drug catabolic process (GO:0042737)3.93866143
93sterol transport (GO:0015918)3.91694157
94cholesterol transport (GO:0030301)3.91694157
95lipoprotein metabolic process (GO:0042157)3.90579311
96ketone body metabolic process (GO:1902224)3.87958024
97negative regulation of complement activation (GO:0045916)3.87956224
98positive regulation of coagulation (GO:0050820)3.87794029
99blood coagulation, intrinsic pathway (GO:0007597)3.87214556
100positive regulation of lipoprotein lipase activity (GO:0051006)3.86059511
101positive regulation of triglyceride lipase activity (GO:0061365)3.86059511
102negative regulation of lipase activity (GO:0060192)3.83636408
103cofactor catabolic process (GO:0051187)3.81845825
104very-low-density lipoprotein particle assembly (GO:0034379)3.78029315
105intestinal absorption (GO:0050892)3.77936035
106positive regulation of lipid catabolic process (GO:0050996)3.77791695
107glucuronate metabolic process (GO:0019585)3.77427948
108uronic acid metabolic process (GO:0006063)3.77427948
109complement activation, classical pathway (GO:0006958)3.76819080
110peptidyl-glutamic acid modification (GO:0018200)3.75346651
111cholesterol homeostasis (GO:0042632)3.75118079
112carboxylic acid catabolic process (GO:0046395)3.73847191
113organic acid catabolic process (GO:0016054)3.73847191
114complement activation (GO:0006956)3.72609230
115protein activation cascade (GO:0072376)3.72125520
116regulation of bile acid biosynthetic process (GO:0070857)3.71278738
117phospholipid homeostasis (GO:0055091)3.71122130
118sterol homeostasis (GO:0055092)3.68861355
119ethanol metabolic process (GO:0006067)3.68490303
120plasma lipoprotein particle organization (GO:0071827)3.67344166
121short-chain fatty acid metabolic process (GO:0046459)3.64872791
122cytolysis (GO:0019835)3.64790841
123acetyl-CoA metabolic process (GO:0006084)3.64616773
124protein-lipid complex assembly (GO:0065005)3.62236685
125regulation of cholesterol homeostasis (GO:2000188)3.61196474
126regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.59166417
127acute inflammatory response (GO:0002526)3.58665708
128NAD biosynthetic process (GO:0009435)3.56780364
129opsonization (GO:0008228)3.54646459
130drug metabolic process (GO:0017144)3.48773559
131regulation of lipoprotein particle clearance (GO:0010984)3.46158791
132diacylglycerol metabolic process (GO:0046339)3.39330136
133positive regulation of steroid metabolic process (GO:0045940)3.38252967
134lipid homeostasis (GO:0055088)3.26360017
135oxidative demethylation (GO:0070989)3.23900130

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.41186189
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.22051931
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.05087026
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.51039411
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.32583299
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.15434792
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.88826581
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.04788594
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.02983033
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.60755340
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10819665
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07809865
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05315078
14* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9521968
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98501842
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97979476
17FOXA2_19822575_ChIP-Seq_HepG2_Human1.59861102
18HTT_18923047_ChIP-ChIP_STHdh_Human1.57377616
19CLOCK_20551151_ChIP-Seq_293T_Human1.54092522
20GATA1_22025678_ChIP-Seq_K562_Human1.41644724
21* HNF4A_19822575_ChIP-Seq_HepG2_Human1.39337581
22TCF4_18268006_ChIP-ChIP_LS174T_Human1.32458314
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30372722
24RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20534159
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18087823
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16686330
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16199486
28RAC3_21632823_ChIP-Seq_H3396_Human1.08335051
29ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07683095
30ZNF274_21170338_ChIP-Seq_K562_Hela1.06072141
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04001843
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03000890
33ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02715185
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00637669
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95529852
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91122222
37SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90859220
38MYC_19829295_ChIP-Seq_ESCs_Human0.90432035
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90306362
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85603044
41EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85091676
42ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84275189
43RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84261705
44AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84062328
45ETV2_25802403_ChIP-Seq_MESCs_Mouse0.83447940
46ERA_21632823_ChIP-Seq_H3396_Human0.82750594
47IRF8_22096565_ChIP-ChIP_GC-B_Human0.82489496
48* OCT4_20526341_ChIP-Seq_ESCs_Human0.80797095
49SOX2_21211035_ChIP-Seq_LN229_Human0.80150216
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80057422
51GATA4_25053715_ChIP-Seq_YYC3_Human0.79350421
52* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.78310695
53PCGF2_27294783_Chip-Seq_ESCs_Mouse0.77691821
54POU5F1_16518401_ChIP-PET_MESCs_Mouse0.77628564
55SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77463829
56KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77287540
57NFE2_27457419_Chip-Seq_LIVER_Mouse0.76703923
58FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76315890
59DNAJC2_21179169_ChIP-ChIP_NT2_Human0.76028525
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75123991
61SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74893065
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.74701344
63HIF1A_21447827_ChIP-Seq_MCF-7_Human0.74555714
64RARA_24833708_ChIP-Seq_LIVER_Mouse0.74182266
65ZNF263_19887448_ChIP-Seq_K562_Human0.71540386
66Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71142550
67PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.71101261
68CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70809140
69FOXH1_21741376_ChIP-Seq_ESCs_Human0.70150613
70IGF1R_20145208_ChIP-Seq_DFB_Human0.68348238
71AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66578367
72SALL4_18804426_ChIP-ChIP_XEN_Mouse0.66553073
73ESR2_21235772_ChIP-Seq_MCF-7_Human0.66400384
74* E2F1_20622854_ChIP-Seq_HELA_Human0.65388797
75SMAD1_18555785_Chip-Seq_ESCs_Mouse0.64537031
76SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.64301840
77RARB_24833708_ChIP-Seq_LIVER_Mouse0.64193654
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.63547761
79RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63516190
80SOX11_22085726_ChIP-Seq_ESNs_Mouse0.63394020
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.62846782
82BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61817639
83KLF5_20875108_ChIP-Seq_MESCs_Mouse0.61617681
84SOX2_22085726_ChIP-Seq_NPCs_Mouse0.60716528
85CSB_26484114_Chip-Seq_FIBROBLAST_Human0.60275236
86* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.60246522
87* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.60246522
88NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60222761
89SUZ12_27294783_Chip-Seq_NPCs_Mouse0.60158211
90RUNX1_27457419_Chip-Seq_LIVER_Mouse0.60155956
91* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59890931
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.58565592
93GBX2_23144817_ChIP-Seq_PC3_Human0.58263132
94CEBPB_22108803_ChIP-Seq_LS180_Human0.57495796
95SOX2_19829295_ChIP-Seq_ESCs_Human0.57138650
96NANOG_19829295_ChIP-Seq_ESCs_Human0.57138650
97GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.56816765
98SMC4_20622854_ChIP-Seq_HELA_Human0.55237529
99ESRRB_18555785_Chip-Seq_ESCs_Mouse0.54709010
100P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.54674668
101LXR_22292898_ChIP-Seq_THP-1_Human0.54612414
102EGR1_19032775_ChIP-ChIP_M12_Human0.54405934
103* NANOG_20526341_ChIP-Seq_ESCs_Human0.54209379
104E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.53520467
105PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53244418
106AR_20517297_ChIP-Seq_VCAP_Human0.52329439
107FOXA1_25552417_ChIP-Seq_VCAP_Human0.52056477
108STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51656744
109MYC_19915707_ChIP-ChIP_AK7_Human0.51573314
110FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51143732
111FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49301626
112ESET_19884257_ChIP-Seq_ESCs_Mouse0.48947329
113CBP_21632823_ChIP-Seq_H3396_Human0.47879549
114STAT1_17558387_ChIP-Seq_HELA_Human0.47253566
115P53_21459846_ChIP-Seq_SAOS-2_Human0.46988023
116PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45782241
117PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44291874
118PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43505090
119ESR1_21235772_ChIP-Seq_MCF-7_Human0.43217669
120TAF15_26573619_Chip-Seq_HEK293_Human0.43112074
121CDX2_20551321_ChIP-Seq_CACO-2_Human0.43060891
122SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42501299
123GATA1_19941827_ChIP-Seq_MEL_Mouse0.41521667
124ERG_21242973_ChIP-ChIP_JURKAT_Human0.41494862
125GATA1_19941826_ChIP-Seq_K562_Human0.41102676
126FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.40264762
127FOXO3_23340844_ChIP-Seq_DLD1_Human0.40228863
128BCAT_22108803_ChIP-Seq_LS180_Human0.39557545
129* TAF2_19829295_ChIP-Seq_ESCs_Human0.39044103
130GATA2_19941826_ChIP-Seq_K562_Human0.38749990
131ESR1_20079471_ChIP-ChIP_T-47D_Human0.38715771
132FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.38654968
133PPAR_26484153_Chip-Seq_NCI-H1993_Human0.38150648
134STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38124571
135GATA6_25053715_ChIP-Seq_YYC3_Human0.37482342
136* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.36821964
137* MYC_27129775_Chip-Seq_CORNEA_Mouse0.36022453
138SPI1_26923725_Chip-Seq_HPCs_Mouse0.35338364
139NCOR_22424771_ChIP-Seq_293T_Human0.34587391
140CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.34350199
141FOXH1_21741376_ChIP-Seq_EPCs_Human0.33949647
142* LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.33937924
143ERG_20517297_ChIP-Seq_VCAP_Human0.33342316
144SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.33244556
145* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.32831505

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.37148946
2MP0005360_urolithiasis7.51597581
3MP0005085_abnormal_gallbladder_physiolo6.45784549
4MP0005365_abnormal_bile_salt6.19156887
5MP0008875_abnormal_xenobiotic_pharmacok5.18224096
6MP0003806_abnormal_nucleotide_metabolis4.24331384
7MP0003252_abnormal_bile_duct3.90203518
8MP0010329_abnormal_lipoprotein_level3.60569193
9MP0003122_maternal_imprinting3.55379505
10MP0009840_abnormal_foam_cell3.36565459
11MP0005083_abnormal_biliary_tract3.05537074
12MP0003195_calcinosis2.87257111
13MP0005332_abnormal_amino_acid2.75767409
14MP0001666_abnormal_nutrient_absorption2.58776393
15MP0003191_abnormal_cellular_cholesterol2.36884135
16* MP0000609_abnormal_liver_physiology2.13245435
17MP0004019_abnormal_vitamin_homeostasis2.12887076
18MP0002118_abnormal_lipid_homeostasis2.10766440
19MP0000566_synostosis2.09546370
20MP0002138_abnormal_hepatobiliary_system1.96236525
21MP0003868_abnormal_feces_composition1.93572281
22MP0005319_abnormal_enzyme/_coenzyme1.82600584
23MP0001764_abnormal_homeostasis1.67606702
24MP0009697_abnormal_copulation1.60920713
25MP0005584_abnormal_enzyme/coenzyme_acti1.56945962
26MP0003172_abnormal_lysosome_physiology1.54367177
27MP0002089_abnormal_postnatal_growth/wei1.49384263
28MP0005451_abnormal_body_composition1.49372439
29MP0003123_paternal_imprinting1.43260092
30MP0003011_delayed_dark_adaptation1.41775693
31MP0003186_abnormal_redox_activity1.26563232
32MP0003656_abnormal_erythrocyte_physiolo1.26484842
33MP0009643_abnormal_urine_homeostasis1.21852438
34MP0000598_abnormal_liver_morphology1.17481136
35MP0001915_intracranial_hemorrhage1.16421514
36MP0003705_abnormal_hypodermis_morpholog1.14965145
37MP0005647_abnormal_sex_gland1.14125440
38MP0005167_abnormal_blood-brain_barrier1.10203559
39MP0000604_amyloidosis1.09933695
40MP0003121_genomic_imprinting1.08210368
41MP0009764_decreased_sensitivity_to1.06440590
42MP0003878_abnormal_ear_physiology1.02465255
43MP0005377_hearing/vestibular/ear_phenot1.02465255
44MP0005058_abnormal_lysosome_morphology1.01759778
45MP0002254_reproductive_system_inflammat0.99996075
46MP0006292_abnormal_olfactory_placode0.97891718
47* MP0009763_increased_sensitivity_to0.96957347
48MP0010368_abnormal_lymphatic_system0.96656683
49MP0005636_abnormal_mineral_homeostasis0.91389782
50MP0005410_abnormal_fertilization0.91279589
51MP0008469_abnormal_protein_level0.88547285
52* MP0009642_abnormal_blood_homeostasis0.86022718
53MP0003879_abnormal_hair_cell0.84361222
54MP0005408_hypopigmentation0.83648187
55MP0006036_abnormal_mitochondrial_physio0.82077644
56MP0005376_homeostasis/metabolism_phenot0.79948551
57MP0003567_abnormal_fetal_cardiomyocyte0.79277113
58MP0009765_abnormal_xenobiotic_induced0.78491245
59MP0005670_abnormal_white_adipose0.77887312
60MP0002876_abnormal_thyroid_physiology0.77369199
61MP0002078_abnormal_glucose_homeostasis0.77193985
62MP0005551_abnormal_eye_electrophysiolog0.76631537
63MP0005084_abnormal_gallbladder_morpholo0.73871846
64MP0002938_white_spotting0.73112094
65MP0002282_abnormal_trachea_morphology0.72022663
66MP0002971_abnormal_brown_adipose0.71261295
67MP0005220_abnormal_exocrine_pancreas0.70504660
68MP0003690_abnormal_glial_cell0.68534458
69MP0005334_abnormal_fat_pad0.68328732
70MP0004130_abnormal_muscle_cell0.67493904
71MP0009053_abnormal_anal_canal0.66566504
72MP0005535_abnormal_body_temperature0.66454954
73MP0001661_extended_life_span0.65471867
74MP0005266_abnormal_metabolism0.64672674
75MP0002909_abnormal_adrenal_gland0.63796067
76MP0003329_amyloid_beta_deposits0.63278211
77MP0000639_abnormal_adrenal_gland0.61669042
78MP0009780_abnormal_chondrocyte_physiolo0.58327931
79MP0005646_abnormal_pituitary_gland0.58303997
80MP0001756_abnormal_urination0.57613802
81MP0006035_abnormal_mitochondrial_morpho0.56374701
82MP0001324_abnormal_eye_pigmentation0.55457224
83MP0001529_abnormal_vocalization0.55395575
84MP0005448_abnormal_energy_balance0.54616502
85MP0005464_abnormal_platelet_physiology0.53197684
86MP0002822_catalepsy0.50901413
87MP0005379_endocrine/exocrine_gland_phen0.49955386
88MP0003632_abnormal_nervous_system0.49606782
89MP0005395_other_phenotype0.49027384
90MP0003638_abnormal_response/metabolism_0.46592691
91MP0008874_decreased_physiological_sensi0.46554634
92MP0003718_maternal_effect0.46210786
93MP0008873_increased_physiological_sensi0.45194867
94MP0003633_abnormal_nervous_system0.44055219
95MP0002136_abnormal_kidney_physiology0.43861579
96MP0006054_spinal_hemorrhage0.43854961
97MP0002928_abnormal_bile_duct0.43641947
98MP0004782_abnormal_surfactant_physiolog0.42823257
99MP0003436_decreased_susceptibility_to0.41970375
100MP0002837_dystrophic_cardiac_calcinosis0.41726845
101MP0005248_abnormal_Harderian_gland0.41491542
102MP0003075_altered_response_to0.41087567
103MP0003631_nervous_system_phenotype0.40957301
104MP0003724_increased_susceptibility_to0.40948824
105MP0004043_abnormal_pH_regulation0.40769691
106MP0003943_abnormal_hepatobiliary_system0.40407456
107MP0003953_abnormal_hormone_level0.40376658
108MP0005257_abnormal_intraocular_pressure0.39009339
109MP0001270_distended_abdomen0.38965740
110MP0008872_abnormal_physiological_respon0.38631408
111MP0002249_abnormal_larynx_morphology0.38062513
112MP0005166_decreased_susceptibility_to0.38028913
113MP0004381_abnormal_hair_follicle0.37941800
114MP0002160_abnormal_reproductive_system0.37621688
115MP0001293_anophthalmia0.36333455
116MP0009672_abnormal_birth_weight0.36315569
117MP0005666_abnormal_adipose_tissue0.36311766
118MP0001986_abnormal_taste_sensitivity0.35438928
119MP0004742_abnormal_vestibular_system0.35129605
120MP0000920_abnormal_myelination0.35002278
121MP0000579_abnormal_nail_morphology0.34066629
122MP0005409_darkened_coat_color0.33961587
123MP0000249_abnormal_blood_vessel0.32876709
124MP0002796_impaired_skin_barrier0.32348699
125MP0004883_abnormal_blood_vessel0.32337798
126MP0009115_abnormal_fat_cell0.32335763
127MP0001243_abnormal_dermal_layer0.31852754
128MP0006082_CNS_inflammation0.31588297
129MP0000230_abnormal_systemic_arterial0.31009765
130MP0002168_other_aberrant_phenotype0.30896536
131MP0009384_cardiac_valve_regurgitation0.29966236
132MP0002970_abnormal_white_adipose0.29933092
133MP0001853_heart_inflammation0.29851211
134MP0001881_abnormal_mammary_gland0.27627896
135MP0001845_abnormal_inflammatory_respons0.27496077
136MP0005164_abnormal_response_to0.25116079
137MP0002090_abnormal_vision0.24071796
138MP0002132_abnormal_respiratory_system0.23372652
139MP0002060_abnormal_skin_morphology0.23154906

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.49515981
2Deep venous thrombosis (HP:0002625)7.47166333
3Intrahepatic cholestasis (HP:0001406)7.28155281
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.72962515
5Prolonged partial thromboplastin time (HP:0003645)6.60910385
6Hypobetalipoproteinemia (HP:0003563)6.51715911
7Xanthomatosis (HP:0000991)6.30952627
8Hyperlipoproteinemia (HP:0010980)5.72927690
9Complement deficiency (HP:0004431)5.33555140
10Hypolipoproteinemia (HP:0010981)4.86480646
11Joint hemorrhage (HP:0005261)4.82929758
12Hyperammonemia (HP:0001987)4.61942248
13Epidermoid cyst (HP:0200040)4.50930362
14Abnormality of the common coagulation pathway (HP:0010990)4.47861708
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.44774180
16Hyperglycinemia (HP:0002154)4.40126740
17Abnormality of methionine metabolism (HP:0010901)4.33812210
18Ketosis (HP:0001946)4.26701801
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.26690393
20Hypoalphalipoproteinemia (HP:0003233)4.26478351
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.14624626
22Fat malabsorption (HP:0002630)4.10016479
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.09751152
24Abnormality of complement system (HP:0005339)3.89224835
25Hyperglycinuria (HP:0003108)3.87997106
26Abnormality of serine family amino acid metabolism (HP:0010894)3.87549432
27Abnormality of glycine metabolism (HP:0010895)3.87549432
28Abnormality of pyrimidine metabolism (HP:0004353)3.87064339
29Hypoglycemic coma (HP:0001325)3.84581819
30Abnormality of the intrinsic pathway (HP:0010989)3.78061137
31Conjugated hyperbilirubinemia (HP:0002908)3.66278430
32Hypercholesterolemia (HP:0003124)3.62374600
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.39450508
34Abnormality of fatty-acid metabolism (HP:0004359)3.35093564
35Hyperbilirubinemia (HP:0002904)3.34089351
36Steatorrhea (HP:0002570)3.11318333
37Delayed CNS myelination (HP:0002188)3.11157707
38Spontaneous abortion (HP:0005268)3.07513733
39Purpura (HP:0000979)3.06747538
40Abnormality of serum amino acid levels (HP:0003112)3.06446696
41Abnormality of nucleobase metabolism (HP:0010932)3.05740324
42Ketoacidosis (HP:0001993)2.98828799
43Hepatocellular carcinoma (HP:0001402)2.98225737
44Hypochromic microcytic anemia (HP:0004840)2.97751363
45Myocardial infarction (HP:0001658)2.93496007
46Skin nodule (HP:0200036)2.77645518
47Metabolic acidosis (HP:0001942)2.77151768
48Systemic lupus erythematosus (HP:0002725)2.71883972
49Abnormality of purine metabolism (HP:0004352)2.65078317
50Lethargy (HP:0001254)2.61145466
51Vascular calcification (HP:0004934)2.58283108
52Dicarboxylic aciduria (HP:0003215)2.58049154
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.58049154
54Acanthocytosis (HP:0001927)2.49095974
55Abnormal gallbladder morphology (HP:0012437)2.47702177
56Spastic diplegia (HP:0001264)2.46909153
57Hypoglycemic seizures (HP:0002173)2.45990926
58Arthropathy (HP:0003040)2.44782268
59Glomerulonephritis (HP:0000099)2.44396490
60Broad alveolar ridges (HP:0000187)2.44352943
61Cerebral edema (HP:0002181)2.43132069
62Mitral stenosis (HP:0001718)2.42162976
63Gout (HP:0001997)2.41925259
64Cholelithiasis (HP:0001081)2.41779630
65Cholecystitis (HP:0001082)2.39346584
66Abnormal gallbladder physiology (HP:0012438)2.39346584
67Osteomalacia (HP:0002749)2.38333363
68Pancreatic islet-cell hyperplasia (HP:0004510)2.36219563
69Neonatal onset (HP:0003623)2.35796289
70Irritability (HP:0000737)2.35538098
71Amyloidosis (HP:0011034)2.34695353
72Potter facies (HP:0002009)2.32630315
73Facial shape deformation (HP:0011334)2.32630315
74Recurrent gram-negative bacterial infections (HP:0005420)2.31771197
75Cardiovascular calcification (HP:0011915)2.28927761
76Malnutrition (HP:0004395)2.25914991
77Increased serum pyruvate (HP:0003542)2.25586492
78Abnormality of carpal bone ossification (HP:0006257)2.24003012
79Gingival bleeding (HP:0000225)2.23411953
80Esophageal varix (HP:0002040)2.18933292
81Menorrhagia (HP:0000132)2.16869650
82Brushfield spots (HP:0001088)2.15856904
83Pulmonary embolism (HP:0002204)2.14818853
84Sensorimotor neuropathy (HP:0007141)2.14339050
85Pancreatitis (HP:0001733)2.13263591
86Late onset (HP:0003584)2.13008037
87Enlarged kidneys (HP:0000105)2.10701519
88Thrombophlebitis (HP:0004418)2.10101366
89Abnormal tarsal ossification (HP:0008369)2.08875581
90Vomiting (HP:0002013)2.06704869
91Vaginal fistula (HP:0004320)2.06476567
92Opisthotonus (HP:0002179)2.03113413
93Small epiphyses (HP:0010585)2.01234900
94Abnormality of the gallbladder (HP:0005264)2.01034684
95Generalized aminoaciduria (HP:0002909)2.00999784
96Abnormality of glycolysis (HP:0004366)2.00156919
97Hemorrhage of the eye (HP:0011885)1.99787668
98Hyperinsulinemic hypoglycemia (HP:0000825)1.99473564
99Poikilocytosis (HP:0004447)1.99103582
100Hepatoblastoma (HP:0002884)1.95402326
101Rickets (HP:0002748)1.93432341
102Abnormality of iron homeostasis (HP:0011031)1.92821069
103Hypothermia (HP:0002045)1.91197599
104Widely patent fontanelles and sutures (HP:0004492)1.90550122
105Abnormality of transition element cation homeostasis (HP:0011030)1.88633922
106Abnormal cartilage morphology (HP:0002763)1.88390504
107Hypophosphatemic rickets (HP:0004912)1.87207409
108Retinal atrophy (HP:0001105)1.87165906
109Abnormality of the nasal septum (HP:0000419)1.85027543
110Renal cortical cysts (HP:0000803)1.84518371
111Abnormality of proline metabolism (HP:0010907)1.81804075
112Hydroxyprolinuria (HP:0003080)1.81804075
113Bifid scrotum (HP:0000048)1.81426864
114Elevated hepatic transaminases (HP:0002910)1.81139088
115Status epilepticus (HP:0002133)1.80981547
116Alkalosis (HP:0001948)1.80435959
117Abnormal enzyme/coenzyme activity (HP:0012379)1.78219977
118Glycosuria (HP:0003076)1.77734980
119Abnormality of urine glucose concentration (HP:0011016)1.77734980
120Pigmentary retinal degeneration (HP:0001146)1.76439372
121Nephritis (HP:0000123)1.73797982
122Reduced antithrombin III activity (HP:0001976)1.73688723
123Abnormality of vitamin metabolism (HP:0100508)1.73456285
124Hyperglycemia (HP:0003074)1.71171158
125Diastasis recti (HP:0001540)1.71019984
126Fair hair (HP:0002286)1.70916964
127Neoplasm of the liver (HP:0002896)1.67755429
128Gangrene (HP:0100758)1.66147094
129Abnormality of the vitreous humor (HP:0004327)1.63402697
130Joint swelling (HP:0001386)1.63077229
131Epiphyseal dysplasia (HP:0002656)1.62605993
132Abnormal hand bone ossification (HP:0010660)1.62216251
133Abnormality of the lumbar spine (HP:0100712)1.61988875
134Hyperphosphaturia (HP:0003109)1.61912609
135Abnormality of the Achilles tendon (HP:0005109)1.61834439
136Submucous cleft hard palate (HP:0000176)1.60992628
137Epistaxis (HP:0000421)1.59137757

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.28008345
2FGFR44.63680531
3SIK14.56195609
4WNK44.46795690
5ERN14.44385509
6TAOK33.02758025
7INSRR2.89875594
8ERBB42.87039187
9TYRO32.51143452
10MAP2K42.38047253
11PKN22.30479101
12SIK22.22369685
13FGFR12.11237681
14MST1R2.07332532
15FLT31.96251577
16MAPK111.85775818
17PIK3CG1.83230231
18TRIB31.82018815
19NTRK31.73950816
20TYK21.69089347
21MAP4K21.65564973
22LATS11.62979985
23WNK11.59225819
24DAPK21.56878767
25ABL21.50121570
26PTK61.47234302
27CDK121.42395239
28NEK91.38409191
29FGFR21.37956880
30FRK1.37414441
31KDR1.32699653
32AKT31.29589711
33JAK21.21453815
34PINK11.18528718
35MAP3K71.18087254
36DDR21.10291208
37PRKAA21.10253161
38MAP2K31.09020471
39GRK61.08767964
40TBK11.08090386
41BCR1.03047383
42ERBB21.00037867
43MAPK40.99801529
44JAK10.99654059
45WNK30.95342548
46MAP3K140.95237848
47MAP3K100.95069655
48FGR0.93559521
49NTRK20.93230680
50PRKCZ0.92941914
51SGK10.89713563
52PDGFRA0.88987747
53MAPK150.87400983
54MAP3K30.86643117
55EPHB10.84613462
56CSNK1E0.84559521
57DYRK20.83929927
58STK38L0.83921950
59MET0.82879241
60CDK60.82298364
61MAPK120.82004421
62MAP3K110.80652548
63CDK70.79987631
64TIE10.79073632
65PRKACG0.76061308
66EPHA30.74851692
67CAMK2G0.73134887
68MAP2K60.71683005
69CASK0.70811423
70CSK0.70710836
71MAPKAPK30.70504945
72DYRK1B0.70269919
73MAP3K20.69072923
74CSNK1D0.67552142
75BMPR1B0.67425382
76GSK3A0.66982184
77EIF2AK10.66402010
78CAMK1D0.65195841
79PRKG10.63505359
80PRKAA10.63323914
81IRAK30.62055757
82MATK0.61821934
83SGK30.61033475
84RIPK10.60864296
85RPS6KB10.60021927
86ADRBK20.59911643
87MAPK70.58805210
88TGFBR20.57840824
89STK390.55954554
90PTK20.55749121
91IKBKE0.55197183
92FGFR30.55193922
93CSF1R0.55159250
94PRKCQ0.52131874
95PDPK10.52035699
96PRKACA0.50994845
97EPHA40.50757273
98CSNK1G10.50457716
99TAOK20.48658424
100NME10.45832219
101MARK10.44740018
102GRK10.44676331
103MAP3K50.44616155
104SGK20.43373045
105RET0.43135637
106MAP2K10.43122571
107IGF1R0.43099154
108PRKCG0.42196324
109CSNK2A10.41973738
110CSNK2A20.41790971
111MAP3K130.41066290
112CDK40.40715609
113CAMKK20.39694310
114RPS6KA30.38957055
115ICK0.38644635
116PKN10.37482513
117MAP3K60.37370513
118PBK0.37086803
119SRC0.36560917
120PRKACB0.36438862
121PRKCB0.34335140
122CAMK40.34277295
123MTOR0.33538550
124EGFR0.33031114
125PDK10.32239659
126CSNK1G20.31536139
127CSNK1A10.30237208
128STK160.30227115
129SGK2230.30012399
130SGK4940.30012399
131CSNK1G30.29440913
132MAP3K40.28061037
133MAP3K10.28040289
134LATS20.27868197
135BRSK10.27510878
136ITK0.26865030
137BRSK20.26006454
138NEK20.25960773
139PRKCA0.25912089
140IRAK20.25887374
141IRAK10.24193900
142MAP2K20.23266658
143ABL10.20830001
144PAK30.19917509
145CAMK1G0.19817426
146CSNK1A1L0.19811966
147PIK3CA0.19802623

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.54563141
2Nitrogen metabolism_Homo sapiens_hsa009103.54978152
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.40021901
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.36321642
5Arginine biosynthesis_Homo sapiens_hsa002203.08632334
6Complement and coagulation cascades_Homo sapiens_hsa046102.77352452
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71202167
8Tryptophan metabolism_Homo sapiens_hsa003802.68676278
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62518887
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.54502542
11Fatty acid degradation_Homo sapiens_hsa000712.48129193
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37470334
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.25510713
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.15518908
15Butanoate metabolism_Homo sapiens_hsa006502.14047072
16Peroxisome_Homo sapiens_hsa041462.08752210
17Chemical carcinogenesis_Homo sapiens_hsa052041.97593793
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.95244202
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.94721849
20Propanoate metabolism_Homo sapiens_hsa006401.91072151
21Histidine metabolism_Homo sapiens_hsa003401.90136397
22PPAR signaling pathway_Homo sapiens_hsa033201.87346567
23Fatty acid metabolism_Homo sapiens_hsa012121.80201438
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.77764761
25Staphylococcus aureus infection_Homo sapiens_hsa051501.75984479
26Caffeine metabolism_Homo sapiens_hsa002321.75919897
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74888521
28Retinol metabolism_Homo sapiens_hsa008301.72091510
29beta-Alanine metabolism_Homo sapiens_hsa004101.70015737
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66090964
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61060055
32Selenocompound metabolism_Homo sapiens_hsa004501.58332572
33Phenylalanine metabolism_Homo sapiens_hsa003601.56881472
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51994069
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51527800
36Bile secretion_Homo sapiens_hsa049761.49354483
37Tyrosine metabolism_Homo sapiens_hsa003501.45330805
38Pyruvate metabolism_Homo sapiens_hsa006201.35619513
39Sulfur metabolism_Homo sapiens_hsa009201.35256689
40Fatty acid elongation_Homo sapiens_hsa000621.34236967
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.33478712
42Starch and sucrose metabolism_Homo sapiens_hsa005001.27419822
43Folate biosynthesis_Homo sapiens_hsa007901.22671096
44Biosynthesis of amino acids_Homo sapiens_hsa012301.20571473
45Steroid biosynthesis_Homo sapiens_hsa001001.19040564
46ABC transporters_Homo sapiens_hsa020101.18322380
47Fat digestion and absorption_Homo sapiens_hsa049751.16387260
48Carbon metabolism_Homo sapiens_hsa012001.12087908
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03616864
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.99652436
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.98343270
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97647574
53Arginine and proline metabolism_Homo sapiens_hsa003300.96351416
54Sulfur relay system_Homo sapiens_hsa041220.95885526
55Vitamin B6 metabolism_Homo sapiens_hsa007500.93460213
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87093080
57Vitamin digestion and absorption_Homo sapiens_hsa049770.84430248
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83592017
59Other glycan degradation_Homo sapiens_hsa005110.81698958
60Lysine degradation_Homo sapiens_hsa003100.79902296
61One carbon pool by folate_Homo sapiens_hsa006700.75601934
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69683988
63Glycerolipid metabolism_Homo sapiens_hsa005610.66546506
64Glutathione metabolism_Homo sapiens_hsa004800.65300912
65Pentose phosphate pathway_Homo sapiens_hsa000300.58218370
66Fatty acid biosynthesis_Homo sapiens_hsa000610.52526083
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46176649
68Metabolic pathways_Homo sapiens_hsa011000.46020483
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40245865
70Pertussis_Homo sapiens_hsa051330.38960810
71Prion diseases_Homo sapiens_hsa050200.36255295
72N-Glycan biosynthesis_Homo sapiens_hsa005100.34762990
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29867016
74Mineral absorption_Homo sapiens_hsa049780.29013268
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25320522
76Galactose metabolism_Homo sapiens_hsa000520.25102564
77Fructose and mannose metabolism_Homo sapiens_hsa000510.24128863
78Linoleic acid metabolism_Homo sapiens_hsa005910.23190494
79Insulin resistance_Homo sapiens_hsa049310.22452639
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.21315137
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19115978
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.15998684
83Sphingolipid metabolism_Homo sapiens_hsa006000.13013940
84Glucagon signaling pathway_Homo sapiens_hsa049220.09579080
85* Thyroid hormone synthesis_Homo sapiens_hsa049180.02833067
86AMPK signaling pathway_Homo sapiens_hsa041520.01483102
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.00266217
88Bladder cancer_Homo sapiens_hsa05219-0.2515770
89Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2437051
90Ether lipid metabolism_Homo sapiens_hsa00565-0.2432069
91Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2399066
92Amoebiasis_Homo sapiens_hsa05146-0.2390697
93Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2288587
94Renin-angiotensin system_Homo sapiens_hsa04614-0.1978713
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1966342
96Hepatitis C_Homo sapiens_hsa05160-0.1821019
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1780216
98Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1624634
99Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1561812
100Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1552557
101Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1504895
102African trypanosomiasis_Homo sapiens_hsa05143-0.1378656
103Regulation of autophagy_Homo sapiens_hsa04140-0.1341888
104Circadian rhythm_Homo sapiens_hsa04710-0.1267236
105Insulin signaling pathway_Homo sapiens_hsa04910-0.1059344
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.1042154
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0858917
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0757430
109Protein export_Homo sapiens_hsa03060-0.0748733
110Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0684175
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0360302

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