ASB9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ankyrin repeat and suppressor of cytokine signaling (SOCS) box protein family. Members of this family can interact with the elongin B-C adapter complex via their SOCS box domain and further complex with the cullin and ring box proteins to form E3 ubiquitin ligase complexes. They may function to mediate the substrate-recognition of the E3 ubiquitin ligases. A transcribed pseudogene of this gene has been identified on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.31004976
2piRNA metabolic process (GO:0034587)9.30704514
3binding of sperm to zona pellucida (GO:0007339)9.19162641
4organic cation transport (GO:0015695)9.12614898
5cell-cell recognition (GO:0009988)9.10646993
6synaptonemal complex assembly (GO:0007130)8.64899857
7spermatid development (GO:0007286)8.46719247
8synaptonemal complex organization (GO:0070193)8.44380015
9plasma membrane fusion (GO:0045026)8.40702492
10epithelial cilium movement (GO:0003351)8.14333615
11axonemal dynein complex assembly (GO:0070286)8.11842715
12reproduction (GO:0000003)7.91253476
13male meiosis (GO:0007140)7.86210286
14cilium or flagellum-dependent cell motility (GO:0001539)7.69668974
15regulation of cilium movement (GO:0003352)7.37954427
16motile cilium assembly (GO:0044458)7.29364830
17cilium movement (GO:0003341)6.71118264
18sperm capacitation (GO:0048240)6.59769420
19DNA methylation involved in gamete generation (GO:0043046)6.44573836
20single fertilization (GO:0007338)6.29665745
21spermatogenesis (GO:0007283)6.12861593
22male gamete generation (GO:0048232)6.10829366
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.06222589
24chromosome organization involved in meiosis (GO:0070192)5.78791060
25fertilization (GO:0009566)5.61336032
26gamete generation (GO:0007276)5.61233349
27negative regulation of inclusion body assembly (GO:0090084)5.54757443
28male meiosis I (GO:0007141)5.32710505
29meiotic nuclear division (GO:0007126)5.26147207
30germ cell development (GO:0007281)5.14819199
31microtubule depolymerization (GO:0007019)5.02659640
32cellular process involved in reproduction in multicellular organism (GO:0022412)5.01674846
33calcium ion-dependent exocytosis (GO:0017156)4.88331298
34RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.74221954
35tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.74221954
36quaternary ammonium group transport (GO:0015697)4.73462194
37amino-acid betaine transport (GO:0015838)4.67491804
38carnitine transport (GO:0015879)4.67491804
39purine nucleotide salvage (GO:0032261)4.59921883
40regulation of microtubule-based movement (GO:0060632)4.59586256
41drug transmembrane transport (GO:0006855)4.59006797
42regulation of inclusion body assembly (GO:0090083)4.51016332
43chromosome condensation (GO:0030261)4.38937891
44multicellular organismal reproductive process (GO:0048609)4.38500662
45negative regulation of acute inflammatory response (GO:0002674)4.34042076
46adenosine metabolic process (GO:0046085)4.28669408
47meiosis I (GO:0007127)4.27579403
48rRNA modification (GO:0000154)4.26509187
49DNA packaging (GO:0006323)4.24339140
50ventricular system development (GO:0021591)4.23928471
51cell recognition (GO:0008037)4.17901967
52microtubule severing (GO:0051013)4.10019059
53spermatid nucleus differentiation (GO:0007289)4.07827524
54regulation of plasminogen activation (GO:0010755)3.99165362
55mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.96172571
56glycerol ether metabolic process (GO:0006662)3.93930606
57sulfur amino acid catabolic process (GO:0000098)3.88091317
58mitochondrial RNA metabolic process (GO:0000959)3.87683519
59proteasome assembly (GO:0043248)3.84910409
60drug transport (GO:0015893)3.84051515
61folic acid-containing compound biosynthetic process (GO:0009396)3.83774342
62urate metabolic process (GO:0046415)3.77922495
63protein complex biogenesis (GO:0070271)3.76294279
64branched-chain amino acid catabolic process (GO:0009083)3.74827896
65carnitine transmembrane transport (GO:1902603)3.73200998
66polyol catabolic process (GO:0046174)3.70885810
67mitochondrial respiratory chain complex I assembly (GO:0032981)3.69141566
68NADH dehydrogenase complex assembly (GO:0010257)3.69141566
69mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.69141566
70ether metabolic process (GO:0018904)3.61577539
71response to mercury ion (GO:0046689)3.60316818
72aminoglycoside antibiotic metabolic process (GO:0030647)3.59348419
73pseudouridine synthesis (GO:0001522)3.59272703
74seminiferous tubule development (GO:0072520)3.58715291
75nucleoside transmembrane transport (GO:1901642)3.57399065
76left/right pattern formation (GO:0060972)3.54743069
77transcription from mitochondrial promoter (GO:0006390)3.52260982
78rRNA methylation (GO:0031167)3.51943018
79homocysteine metabolic process (GO:0050667)3.49259251
80cysteine metabolic process (GO:0006534)3.48015550
81mitochondrial respiratory chain complex assembly (GO:0033108)3.46337425
82multicellular organismal development (GO:0007275)3.45946604
83mannosylation (GO:0097502)3.42949282
84regulation of meiosis I (GO:0060631)3.42945154
85pteridine-containing compound biosynthetic process (GO:0042559)3.42438072
86aldehyde catabolic process (GO:0046185)3.41357961
87regulation of spindle checkpoint (GO:0090231)3.40425285
88platelet dense granule organization (GO:0060155)3.38856114
89ATP synthesis coupled proton transport (GO:0015986)3.37257318
90energy coupled proton transport, down electrochemical gradient (GO:0015985)3.37257318
91meiotic cell cycle process (GO:1903046)3.37112309
92nitric oxide mediated signal transduction (GO:0007263)3.34117473
93regulation of hexokinase activity (GO:1903299)3.33902809
94regulation of glucokinase activity (GO:0033131)3.33902809
95mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.26363564
96cellular ketone body metabolic process (GO:0046950)3.24960884
97chaperone-mediated protein complex assembly (GO:0051131)3.24575793
98protein polyglutamylation (GO:0018095)3.21808806
99genitalia morphogenesis (GO:0035112)3.19939566
100gene silencing by RNA (GO:0031047)3.19576581
101vitamin catabolic process (GO:0009111)3.19481776
102fat-soluble vitamin catabolic process (GO:0042363)3.19481776
103protein-cofactor linkage (GO:0018065)3.18095387
104synapsis (GO:0007129)3.17425615
105fat-soluble vitamin biosynthetic process (GO:0042362)3.17411157
106branched-chain amino acid metabolic process (GO:0009081)3.16876902
107regulation of cellular amino acid metabolic process (GO:0006521)3.16866182
108meiotic cell cycle (GO:0051321)3.15221783
109xenobiotic catabolic process (GO:0042178)3.14946883
110preassembly of GPI anchor in ER membrane (GO:0016254)3.13150337
111L-phenylalanine catabolic process (GO:0006559)3.11568666
112erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.11568666
113alditol metabolic process (GO:0019400)3.10743237
114purine-containing compound salvage (GO:0043101)3.10323119
115L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.07861747
116carnitine metabolic process (GO:0009437)3.07841814
117daunorubicin metabolic process (GO:0044597)3.06352405
118polyketide metabolic process (GO:0030638)3.06352405
119doxorubicin metabolic process (GO:0044598)3.06352405
120fructose metabolic process (GO:0006000)3.04171861
121water-soluble vitamin biosynthetic process (GO:0042364)3.03953820
122regulation of mitochondrial translation (GO:0070129)3.03208701
123sexual reproduction (GO:0019953)3.02123226
124microtubule polymerization or depolymerization (GO:0031109)3.00937339
125single strand break repair (GO:0000012)3.00889422
126protein deneddylation (GO:0000338)3.00482532
127excretion (GO:0007588)3.00052117
128cullin deneddylation (GO:0010388)3.00016577
129vitamin D metabolic process (GO:0042359)2.99782617
130L-phenylalanine metabolic process (GO:0006558)2.99077605
131erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.99077605
132GMP metabolic process (GO:0046037)2.99022500
133fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.98031348
134nucleotide salvage (GO:0043173)2.97662935
135short-chain fatty acid metabolic process (GO:0046459)2.95739289
136respiratory chain complex IV assembly (GO:0008535)2.94994237
137polyol transport (GO:0015791)2.93227332
138monoubiquitinated protein deubiquitination (GO:0035520)2.92166601
139lactate metabolic process (GO:0006089)2.90636056
140amino acid salvage (GO:0043102)2.90151467
141L-methionine salvage (GO:0071267)2.90151467
142L-methionine biosynthetic process (GO:0071265)2.90151467
143protein localization to cilium (GO:0061512)2.89861406
144electron transport chain (GO:0022900)2.89542533
145ketone body metabolic process (GO:1902224)2.89507224
146respiratory electron transport chain (GO:0022904)2.88964280
147lysine metabolic process (GO:0006553)2.88504340
148lysine catabolic process (GO:0006554)2.88504340
149GPI anchor biosynthetic process (GO:0006506)2.88077488
150positive regulation of glycolytic process (GO:0045821)2.86729569
151positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.86322367
152S-adenosylmethionine metabolic process (GO:0046500)2.85548646
153phosphate ion transport (GO:0006817)2.85343778
154C-terminal protein lipidation (GO:0006501)2.84495680
155endocrine pancreas development (GO:0031018)2.82464468
156positive regulation of prostaglandin secretion (GO:0032308)2.81716570
157histamine secretion (GO:0001821)2.79259228
158aggressive behavior (GO:0002118)2.75537901
159DNA deamination (GO:0045006)2.75363398
160amino-acid betaine metabolic process (GO:0006577)2.75032896
161negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.74136911
162DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73250909
163GTP biosynthetic process (GO:0006183)2.72891152
164DNA ligation (GO:0006266)2.70269218
165cytochrome complex assembly (GO:0017004)2.69164339
166exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.68797402
167glycerol metabolic process (GO:0006071)2.68669422
168nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.68496480
169GPI anchor metabolic process (GO:0006505)2.67799224
170tetrahydrofolate metabolic process (GO:0046653)2.67641713
171signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.67311013
172signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.67311013
173signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.67311013
174protein K11-linked deubiquitination (GO:0035871)2.66761810
175inner mitochondrial membrane organization (GO:0007007)2.66470253
176sex differentiation (GO:0007548)2.64336112
177protein refolding (GO:0042026)2.63769071
178intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.63272382
179signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.63272382
180aspartate family amino acid catabolic process (GO:0009068)2.63222703
181histamine transport (GO:0051608)2.63112969
182glycoside metabolic process (GO:0016137)2.62727674
183aromatic amino acid family catabolic process (GO:0009074)2.62131600
184serine family amino acid catabolic process (GO:0009071)2.62001648
185gene silencing (GO:0016458)2.61315044
186oxidative phosphorylation (GO:0006119)2.59707359
187guanosine-containing compound biosynthetic process (GO:1901070)2.59237832
188galactose catabolic process (GO:0019388)2.59178506
189signal transduction involved in DNA integrity checkpoint (GO:0072401)2.58400826
190signal transduction involved in DNA damage checkpoint (GO:0072422)2.58400826
191regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.56562643
192sperm motility (GO:0030317)11.8616265
193cell wall macromolecule catabolic process (GO:0016998)11.2160757
194cell wall macromolecule metabolic process (GO:0044036)11.2160757
195fusion of sperm to egg plasma membrane (GO:0007342)11.1439662
196acrosome assembly (GO:0001675)10.2404500
197sperm-egg recognition (GO:0035036)10.1908208
198acrosome reaction (GO:0007340)10.1262329

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.50497734
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse8.02026491
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.45937283
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.06610031
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.97984103
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.52809008
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.45833101
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.23845403
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.12572918
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.12568581
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.96195565
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.84013509
13SRF_21415370_ChIP-Seq_HL-1_Mouse2.81000769
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.78467312
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.65306479
16VDR_22108803_ChIP-Seq_LS180_Human2.64686697
17EZH2_22144423_ChIP-Seq_EOC_Human2.60138473
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.56304876
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.46468509
20VDR_23849224_ChIP-Seq_CD4+_Human2.30347792
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.26913969
22CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.26094822
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12292135
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11654696
25CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.07864942
26EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.07313751
27FOXP3_21729870_ChIP-Seq_TREG_Human2.05861481
28EGR1_23403033_ChIP-Seq_LIVER_Mouse1.99634265
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.99414809
30ELK1_19687146_ChIP-ChIP_HELA_Human1.98543838
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.98520261
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97862742
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.87191690
34ZNF274_21170338_ChIP-Seq_K562_Hela1.85347895
35STAT1_17558387_ChIP-Seq_HELA_Human1.83396558
36TP53_22573176_ChIP-Seq_HFKS_Human1.81281798
37RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.77954120
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77924765
39* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.75462729
40KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.74250599
41GATA1_26923725_Chip-Seq_HPCs_Mouse1.74212092
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72794255
43FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72009021
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71142459
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68982014
46GATA3_21867929_ChIP-Seq_CD8_Mouse1.65996967
47SOX2_22085726_ChIP-Seq_NPCs_Mouse1.63379535
48GABP_19822575_ChIP-Seq_HepG2_Human1.61399516
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60509573
50AR_20517297_ChIP-Seq_VCAP_Human1.59654294
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.56947405
52FOXA1_27270436_Chip-Seq_PROSTATE_Human1.56128146
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.56128146
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56005606
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.53087167
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52091831
57TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.51897682
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50911927
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49807312
60CBP_20019798_ChIP-Seq_JUKART_Human1.49099127
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49099127
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48602441
63KAP1_22055183_ChIP-Seq_ESCs_Mouse1.47786206
64DCP1A_22483619_ChIP-Seq_HELA_Human1.47665972
65RUNX1_26923725_Chip-Seq_HPCs_Mouse1.46164609
66ELK4_26923725_Chip-Seq_MESODERM_Mouse1.45556827
67GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.44537337
68WDR5_24793694_ChIP-Seq_LNCAP_Human1.42251069
69TAL1_26923725_Chip-Seq_HPCs_Mouse1.39676881
70EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.37989691
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37865932
72SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.37773404
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.35826101
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32918828
75MYC_18940864_ChIP-ChIP_HL60_Human1.32914687
76HTT_18923047_ChIP-ChIP_STHdh_Human1.32908781
77LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.32374706
78EWS_26573619_Chip-Seq_HEK293_Human1.31290323
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.30306887
80EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.29563797
81PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.28800150
82RAD21_21589869_ChIP-Seq_MESCs_Mouse1.28568118
83P53_21459846_ChIP-Seq_SAOS-2_Human1.28220817
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28010009
85KDM2B_26808549_Chip-Seq_REH_Human1.27784932
86FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.27655839
87MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27107023
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26050878
89* FUS_26573619_Chip-Seq_HEK293_Human1.25815676
90GATA3_21867929_ChIP-Seq_TH1_Mouse1.24587365
91CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24483663
92E2F7_22180533_ChIP-Seq_HELA_Human1.22830988
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.20281220
94CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20159716
95CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20020846
96KDM5A_27292631_Chip-Seq_BREAST_Human1.19869415
97* RNF2_27304074_Chip-Seq_NSC_Mouse1.19245834
98GF1_26923725_Chip-Seq_HPCs_Mouse1.19212737
99* CBX2_27304074_Chip-Seq_ESCs_Mouse1.18648425
100SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18326252
101ESET_19884257_ChIP-Seq_ESCs_Mouse1.18115424
102GATA1_19941827_ChIP-Seq_MEL86_Mouse1.17683868
103SOX11_22085726_ChIP-Seq_ESNs_Mouse1.16947030
104SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16614443
105ZNF263_19887448_ChIP-Seq_K562_Human1.16568848
106YY1_21170310_ChIP-Seq_MESCs_Mouse1.16562019
107FLI1_21867929_ChIP-Seq_TH2_Mouse1.16516249
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16306158
109TTF2_22483619_ChIP-Seq_HELA_Human1.15950548
110ERG_20517297_ChIP-Seq_VCAP_Human1.15299036
111SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15073137
112THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14399781
113IGF1R_20145208_ChIP-Seq_DFB_Human1.14166432
114PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13617863
115RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13295097
116NCOR_22424771_ChIP-Seq_293T_Human1.13225926
117SPI1_26923725_Chip-Seq_HPCs_Mouse1.13002154
118PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.12920393
119NANOG_18555785_Chip-Seq_ESCs_Mouse1.11097942
120OCT4_18555785_Chip-Seq_ESCs_Mouse1.10285841
121PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09233820
122SOX2_19829295_ChIP-Seq_ESCs_Human1.08933800
123NANOG_19829295_ChIP-Seq_ESCs_Human1.08933800
124LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08582904
125ESRRB_18555785_Chip-Seq_ESCs_Mouse1.08447941
126NFYB_21822215_ChIP-Seq_K562_Human1.07105830
127CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06452582
128CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06412231
129ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05974550
130PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04303860
131KLF4_18555785_Chip-Seq_ESCs_Mouse1.03893825
132ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01598891
133PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01151356
134CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01028503
135RARA_24833708_ChIP-Seq_LIVER_Mouse1.00963564
136CTCF_20526341_ChIP-Seq_ESCs_Human1.00268583
137FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99620955
138EZH2_27294783_Chip-Seq_NPCs_Mouse0.99335081
139TET1_21451524_ChIP-Seq_MESCs_Mouse0.99133988
140RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99103235
141P53_22387025_ChIP-Seq_ESCs_Mouse0.98061156
142GF1B_26923725_Chip-Seq_HPCs_Mouse0.98056973
143TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97388442
144ETV1_20927104_ChIP-Seq_GIST48_Human0.97019273
145FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96691061
146BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96657011
147PHF8_20622853_ChIP-Seq_HELA_Human0.96473143
148OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96355677
149ER_23166858_ChIP-Seq_MCF-7_Human0.95824815
150SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95227606
151RXR_22158963_ChIP-Seq_LIVER_Mouse0.95225926
152SOX2_21211035_ChIP-Seq_LN229_Human0.95125639
153GATA3_21878914_ChIP-Seq_MCF-7_Human0.94574585
154CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94170044
155PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94155590
156RAC3_21632823_ChIP-Seq_H3396_Human0.93282122
157CDX2_22108803_ChIP-Seq_LS180_Human0.93237523
158ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93038746
159ELF1_20517297_ChIP-Seq_JURKAT_Human0.92374197
160FLI1_21867929_ChIP-Seq_CD8_Mouse0.92246792
161NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.91678699
162HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91500658
163MYC_27129775_Chip-Seq_CORNEA_Mouse0.90504377
164STAT3_18555785_Chip-Seq_ESCs_Mouse0.89528436
165IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.89429200
166CMYC_18555785_Chip-Seq_ESCs_Mouse0.89043050
167CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88968785
168* FOXH1_21741376_ChIP-Seq_ESCs_Human0.88835588
169P300_18555785_Chip-Seq_ESCs_Mouse0.88654555
170NANOG_20526341_ChIP-Seq_ESCs_Human0.87911687
171NFYA_21822215_ChIP-Seq_K562_Human0.87686737
172TBL1_22424771_ChIP-Seq_293T_Human0.87328848
173FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.87002796
174SOX2_18555785_Chip-Seq_ESCs_Mouse0.86860030
175AR_25329375_ChIP-Seq_VCAP_Human0.86090367
176ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85635275
177CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.85601952
178P300_19829295_ChIP-Seq_ESCs_Human0.85014449
179CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.84890879
180CIITA_25753668_ChIP-Seq_RAJI_Human0.84173098
181YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84087168
182TAF2_19829295_ChIP-Seq_ESCs_Human0.83105393
183XRN2_22483619_ChIP-Seq_HELA_Human0.82780933
184RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.82090070
185FOXH1_21741376_ChIP-Seq_EPCs_Human0.81559664
186GATA4_25053715_ChIP-Seq_YYC3_Human0.81359714

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.18539963
2MP0001929_abnormal_gametogenesis4.95565316
3MP0008877_abnormal_DNA_methylation4.92401643
4MP0004043_abnormal_pH_regulation3.68281369
5MP0002210_abnormal_sex_determination3.46653294
6MP0005646_abnormal_pituitary_gland3.35344571
7MP0005360_urolithiasis3.11659092
8MP0001145_abnormal_male_reproductive3.01350239
9MP0000013_abnormal_adipose_tissue2.96725217
10MP0002161_abnormal_fertility/fecundity2.87573179
11MP0009697_abnormal_copulation2.81499764
12MP0001765_abnormal_ion_homeostasis2.81371701
13MP0002139_abnormal_hepatobiliary_system2.73342541
14MP0004147_increased_porphyrin_level2.69840393
15MP0000653_abnormal_sex_gland2.62522220
16MP0005645_abnormal_hypothalamus_physiol2.48841873
17MP0003787_abnormal_imprinting2.45618197
18MP0005670_abnormal_white_adipose2.39017178
19MP0003195_calcinosis2.38895050
20MP0002653_abnormal_ependyma_morphology2.29852492
21MP0010386_abnormal_urinary_bladder2.29190337
22MP0002938_white_spotting2.20022939
23MP0004019_abnormal_vitamin_homeostasis2.18170135
24MP0005084_abnormal_gallbladder_morpholo2.15516583
25MP0003646_muscle_fatigue2.12132312
26MP0008995_early_reproductive_senescence2.08561114
27MP0000516_abnormal_urinary_system2.05255686
28MP0005367_renal/urinary_system_phenotyp2.05255686
29MP0008872_abnormal_physiological_respon2.03911352
30MP0005636_abnormal_mineral_homeostasis2.02330056
31MP0005410_abnormal_fertilization12.7885922
32MP0005332_abnormal_amino_acid1.98591160
33MP0005075_abnormal_melanosome_morpholog1.97301301
34MP0009643_abnormal_urine_homeostasis1.83836844
35MP0003878_abnormal_ear_physiology1.83371891
36MP0005377_hearing/vestibular/ear_phenot1.83371891
37MP0005220_abnormal_exocrine_pancreas1.82524577
38MP0009780_abnormal_chondrocyte_physiolo1.71737022
39MP0002132_abnormal_respiratory_system1.65236764
40MP0001756_abnormal_urination1.44218895
41MP0002138_abnormal_hepatobiliary_system1.42066812
42MP0006072_abnormal_retinal_apoptosis1.39894383
43MP0002736_abnormal_nociception_after1.39701846
44MP0002095_abnormal_skin_pigmentation1.37537507
45MP0003123_paternal_imprinting1.36784792
46MP0002160_abnormal_reproductive_system1.34205365
47MP0002282_abnormal_trachea_morphology1.32614116
48MP0000372_irregular_coat_pigmentation1.32609337
49MP0002166_altered_tumor_susceptibility1.31294362
50MP0002136_abnormal_kidney_physiology1.30060085
51MP0005551_abnormal_eye_electrophysiolog1.29039052
52MP0002006_tumorigenesis1.28867878
53MP0002396_abnormal_hematopoietic_system1.26969733
54MP0000678_abnormal_parathyroid_gland1.26282783
55MP0003121_genomic_imprinting1.22507857
56MP0001905_abnormal_dopamine_level1.17476036
57MP0008058_abnormal_DNA_repair1.16400741
58MP0005623_abnormal_meninges_morphology1.15250574
59MP0003786_premature_aging1.13146972
60MP0003718_maternal_effect1.12812614
61MP0003283_abnormal_digestive_organ1.11844093
62MP0008875_abnormal_xenobiotic_pharmacok1.08882544
63MP0003122_maternal_imprinting1.08392904
64MP0008775_abnormal_heart_ventricle1.05903683
65MP0000003_abnormal_adipose_tissue1.05671230
66MP0006036_abnormal_mitochondrial_physio1.05604009
67MP0004233_abnormal_muscle_weight1.03998889
68MP0003183_abnormal_peptide_metabolism1.03374594
69MP0005266_abnormal_metabolism1.02478168
70MP0002277_abnormal_respiratory_mucosa0.99383768
71MP0005376_homeostasis/metabolism_phenot0.95960461
72MP0002928_abnormal_bile_duct0.90884668
73MP0006276_abnormal_autonomic_nervous0.88316560
74MP0001968_abnormal_touch/_nociception0.85550444
75MP0008961_abnormal_basal_metabolism0.85311345
76MP0005647_abnormal_sex_gland0.84668502
77MP0001919_abnormal_reproductive_system0.81976782
78MP0003656_abnormal_erythrocyte_physiolo0.81439603
79MP0002102_abnormal_ear_morphology0.79517739
80MP0003252_abnormal_bile_duct0.79203765
81MP0005408_hypopigmentation0.78127249
82MP0005365_abnormal_bile_salt0.77176195
83MP0005253_abnormal_eye_physiology0.77056468
84MP0005083_abnormal_biliary_tract0.75658007
85MP0002638_abnormal_pupillary_reflex0.74127359
86MP0003315_abnormal_perineum_morphology0.73621920
87MP0005319_abnormal_enzyme/_coenzyme0.73342572
88MP0000371_diluted_coat_color0.73254352
89MP0002896_abnormal_bone_mineralization0.73133916
90MP0001764_abnormal_homeostasis0.73080782
91MP0005167_abnormal_blood-brain_barrier0.71894033
92MP0005379_endocrine/exocrine_gland_phen0.71517928
93MP0005666_abnormal_adipose_tissue0.70300752
94MP0005330_cardiomyopathy0.69381896
95MP0010329_abnormal_lipoprotein_level0.69334192
96MP0005464_abnormal_platelet_physiology0.67759187
97MP0004145_abnormal_muscle_electrophysio0.67170399
98MP0002796_impaired_skin_barrier0.63914019
99MP0001119_abnormal_female_reproductive0.63321469
100MP0003186_abnormal_redox_activity0.63017730
101MP0001958_emphysema0.59551906
102MP0010094_abnormal_chromosome_stability0.58334725
103MP0003879_abnormal_hair_cell0.57924374
104MP0005389_reproductive_system_phenotype0.57331765
105MP0000358_abnormal_cell_content/0.56098000
106MP0003699_abnormal_female_reproductive0.55285372
107MP0002234_abnormal_pharynx_morphology0.55185541
108MP0000538_abnormal_urinary_bladder0.54715811
109MP0005085_abnormal_gallbladder_physiolo0.54277956
110MP0000534_abnormal_ureter_morphology0.54078681
111MP0004885_abnormal_endolymph0.53221812
112MP0002168_other_aberrant_phenotype0.53001239
113MP0002115_abnormal_skeleton_extremities0.52917577
114MP0005535_abnormal_body_temperature0.50707955
115MP0005584_abnormal_enzyme/coenzyme_acti0.50517911
116MP0001293_anophthalmia0.48467040
117MP0006035_abnormal_mitochondrial_morpho0.48122083
118MP0009046_muscle_twitch0.46829144
119MP0001270_distended_abdomen0.45235039
120MP0002135_abnormal_kidney_morphology0.44488707
121MP0001661_extended_life_span0.42457391
122MP0002876_abnormal_thyroid_physiology0.41795026
123MP0003115_abnormal_respiratory_system0.41412625
124MP0001324_abnormal_eye_pigmentation0.40830900
125MP0004134_abnormal_chest_morphology0.40117751
126MP0009672_abnormal_birth_weight0.39440230
127MP0001984_abnormal_olfaction0.39065111
128MP0002269_muscular_atrophy0.37589218
129MP0009642_abnormal_blood_homeostasis0.37192319
130MP0003953_abnormal_hormone_level0.36895349
131MP0000163_abnormal_cartilage_morphology0.36467108
132MP0000230_abnormal_systemic_arterial0.35396608
133MP0003959_abnormal_lean_body0.35386790
134MP0002118_abnormal_lipid_homeostasis0.35214647
135MP0001944_abnormal_pancreas_morphology0.34597869
136MP0002837_dystrophic_cardiac_calcinosis0.34074645
137MP0004264_abnormal_extraembryonic_tissu0.30796268
138MP0001727_abnormal_embryo_implantation0.30632459
139MP0003806_abnormal_nucleotide_metabolis0.29121228
140MP0001730_embryonic_growth_arrest0.29081079
141MP0004742_abnormal_vestibular_system0.28875848
142MP0003942_abnormal_urinary_system0.27564638
143MP0003795_abnormal_bone_structure0.27374478
144MP0004036_abnormal_muscle_relaxation0.26117244
145MP0002909_abnormal_adrenal_gland0.25923520
146MP0002109_abnormal_limb_morphology0.24356495
147MP0002078_abnormal_glucose_homeostasis0.24286707
148MP0002089_abnormal_postnatal_growth/wei0.24004755
149MP0001986_abnormal_taste_sensitivity0.23445073
150MP0005058_abnormal_lysosome_morphology0.22868274
151MP0002693_abnormal_pancreas_physiology0.22149541
152MP0009703_decreased_birth_body0.21971861

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.78438172
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.34132276
3Absent/shortened dynein arms (HP:0200106)9.34132276
4Abnormal respiratory motile cilium physiology (HP:0012261)6.75054356
5Abnormal respiratory motile cilium morphology (HP:0005938)6.25529035
6Abnormal respiratory epithelium morphology (HP:0012253)6.25529035
7Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.91037812
8Abnormality of alanine metabolism (HP:0010916)5.91037812
9Hyperalaninemia (HP:0003348)5.91037812
10Chronic bronchitis (HP:0004469)5.78110906
11Abnormal drinking behavior (HP:0030082)5.60115786
12Polydipsia (HP:0001959)5.60115786
13Polyuria (HP:0000103)5.52956930
14Abnormal urine output (HP:0012590)5.34590355
15Rhinitis (HP:0012384)5.33557993
16Abnormal ciliary motility (HP:0012262)5.22576651
17Abnormality of renal excretion (HP:0011036)5.19891292
18Infertility (HP:0000789)4.91785495
19Hypoglycemic seizures (HP:0002173)4.56743367
20Ketoacidosis (HP:0001993)4.52819711
21Hypokalemic alkalosis (HP:0001949)4.40987321
22Nasal polyposis (HP:0100582)4.36777904
23Tubular atrophy (HP:0000092)4.24282300
24Metabolic alkalosis (HP:0200114)4.22053794
25Delayed epiphyseal ossification (HP:0002663)4.20038069
26Hypoglycemic coma (HP:0001325)4.18682800
27Hyperinsulinemic hypoglycemia (HP:0000825)4.16933704
28Abnormal spermatogenesis (HP:0008669)4.08098682
29Increased circulating renin level (HP:0000848)4.03277684
30Abnormality of chloride homeostasis (HP:0011422)4.00207438
31Hypomagnesemia (HP:0002917)3.99460879
32Constricted visual fields (HP:0001133)3.84348089
33Symptomatic seizures (HP:0011145)3.69290888
34Nephronophthisis (HP:0000090)3.67306070
35Generalized aminoaciduria (HP:0002909)3.66105704
36Hyperactive renin-angiotensin system (HP:0000841)3.63619808
37Gout (HP:0001997)3.62669535
38Tubulointerstitial fibrosis (HP:0005576)3.58168833
39Hepatic necrosis (HP:0002605)3.56825512
40Abnormality of the nasal mucosa (HP:0000433)3.55495142
41Azoospermia (HP:0000027)3.44710633
42Abnormality of the renal medulla (HP:0100957)3.42243641
43Bronchitis (HP:0012387)3.41939853
44Male infertility (HP:0003251)3.41823212
45Acute necrotizing encephalopathy (HP:0006965)3.41744291
46Abnormality of magnesium homeostasis (HP:0004921)3.30458164
47Mitochondrial inheritance (HP:0001427)3.27817924
48Progressive macrocephaly (HP:0004481)3.18530370
49Bronchiectasis (HP:0002110)3.16292020
50Abnormal mitochondria in muscle tissue (HP:0008316)3.15688425
51Tubulointerstitial abnormality (HP:0001969)3.15230687
52Increased CSF lactate (HP:0002490)3.12604545
53Acute encephalopathy (HP:0006846)3.09473198
54Hyperglycemia (HP:0003074)3.03664872
55Abnormality of the pancreatic islet cells (HP:0006476)3.01628713
56Abnormality of endocrine pancreas physiology (HP:0012093)3.01628713
57Hepatocellular necrosis (HP:0001404)3.01298962
58Abnormality of aromatic amino acid family metabolism (HP:0004338)3.00938509
59Large for gestational age (HP:0001520)3.00425511
60Cerebral edema (HP:0002181)2.98334608
61Decreased electroretinogram (ERG) amplitude (HP:0000654)2.97952291
62Proximal tubulopathy (HP:0000114)2.93087225
63Widely patent fontanelles and sutures (HP:0004492)2.91665039
64Tetany (HP:0001281)2.90953554
65Testicular atrophy (HP:0000029)2.86081828
66Renal salt wasting (HP:0000127)2.82622214
67Increased purine levels (HP:0004368)2.81665319
68Hyperuricemia (HP:0002149)2.81665319
69Increased serum lactate (HP:0002151)2.81628559
703-Methylglutaconic aciduria (HP:0003535)2.80550798
71Abnormality of serum amino acid levels (HP:0003112)2.75412022
72Lactic acidosis (HP:0003128)2.69824060
73Reduced antithrombin III activity (HP:0001976)2.68316639
74Alkalosis (HP:0001948)2.67452657
75Insulin-resistant diabetes mellitus (HP:0000831)2.66057859
76Abnormality of the renal cortex (HP:0011035)2.65694317
77Increased hepatocellular lipid droplets (HP:0006565)2.63489706
78Conjugated hyperbilirubinemia (HP:0002908)2.61064918
79Lethargy (HP:0001254)2.60839904
80Protuberant abdomen (HP:0001538)2.57564674
81Abnormality of renin-angiotensin system (HP:0000847)2.53951984
82Lipid accumulation in hepatocytes (HP:0006561)2.50900390
83Hyperaldosteronism (HP:0000859)2.50367690
84Hypothermia (HP:0002045)2.50120525
85Type I transferrin isoform profile (HP:0003642)2.47962015
86Hyperammonemia (HP:0001987)2.43865931
87Abnormality of methionine metabolism (HP:0010901)2.41741207
88Dicarboxylic aciduria (HP:0003215)2.41284251
89Abnormality of dicarboxylic acid metabolism (HP:0010995)2.41284251
90Patchy hypopigmentation of hair (HP:0011365)2.33606016
91Metaphyseal cupping (HP:0003021)2.32908731
92Epiphyseal dysplasia (HP:0002656)2.29014431
93Hyperphosphaturia (HP:0003109)2.28571212
94Attenuation of retinal blood vessels (HP:0007843)2.27476444
95Abnormality of purine metabolism (HP:0004352)2.26390963
96Recurrent otitis media (HP:0000403)2.24728946
97Increased intramyocellular lipid droplets (HP:0012240)2.24469198
98Abolished electroretinogram (ERG) (HP:0000550)2.23890453
99Enlarged epiphyses (HP:0010580)2.23126272
100Methylmalonic acidemia (HP:0002912)2.23103187
101Metaphyseal irregularity (HP:0003025)2.19533876
102Thin bony cortex (HP:0002753)2.18353168
103Congenital sensorineural hearing impairment (HP:0008527)2.17480673
104Hypercalciuria (HP:0002150)2.17137099
105Increased serum pyruvate (HP:0003542)2.15616255
106Metabolic acidosis (HP:0001942)2.14570319
107Stage 5 chronic kidney disease (HP:0003774)2.14448680
108Pancreatic fibrosis (HP:0100732)2.13939338
109True hermaphroditism (HP:0010459)2.12272866
110Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.11804284
111Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.11406620
112Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.11036883
113Abnormal protein N-linked glycosylation (HP:0012347)2.11036883
114Abnormal protein glycosylation (HP:0012346)2.11036883
115Abnormal glycosylation (HP:0012345)2.11036883
116White forelock (HP:0002211)2.08696560
117Tubulointerstitial nephritis (HP:0001970)2.07993268
118Short ribs (HP:0000773)2.06606984
119Abnormality of aspartate family amino acid metabolism (HP:0010899)2.05825739
120Pancreatic islet-cell hyperplasia (HP:0004510)2.05752156
121Abnormality of the costochondral junction (HP:0000919)2.05728678
122Gonadotropin excess (HP:0000837)2.04904492
123Renal cortical cysts (HP:0000803)2.04874889
124Irregular epiphyses (HP:0010582)2.04458581
125Renal Fanconi syndrome (HP:0001994)2.03867182
126Elevated erythrocyte sedimentation rate (HP:0003565)2.03311454
127Hypokalemia (HP:0002900)2.02473956
128Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.01637180
129Vascular calcification (HP:0004934)2.01492933
130Abnormality of sulfur amino acid metabolism (HP:0004339)1.98625929
131Recurrent sinusitis (HP:0011108)1.97893132
132Abnormality of potassium homeostasis (HP:0011042)1.96666633
133Prolonged partial thromboplastin time (HP:0003645)1.94687451
134Delayed CNS myelination (HP:0002188)1.93235188
135Pancreatic cysts (HP:0001737)1.92912043
136Nephrocalcinosis (HP:0000121)1.92063779
137Impulsivity (HP:0100710)1.90168092
138Respiratory failure (HP:0002878)1.88497833
139Methylmalonic aciduria (HP:0012120)1.88353854
140Aplasia/hypoplasia of the uterus (HP:0008684)1.88051316
141Myoglobinuria (HP:0002913)1.85695932
142Exercise intolerance (HP:0003546)1.85272802
143Recurrent bronchitis (HP:0002837)1.84492485
144Optic disc pallor (HP:0000543)1.82870493
145Increased muscle lipid content (HP:0009058)1.80378210
146Abnormality of glycolysis (HP:0004366)1.80259872
147Abnormality of glutamine family amino acid metabolism (HP:0010902)1.80126046
148Abnormality of midbrain morphology (HP:0002418)1.79777202
149Molar tooth sign on MRI (HP:0002419)1.79777202
150Hypobetalipoproteinemia (HP:0003563)1.79412928
151Fibular hypoplasia (HP:0003038)1.78695102
152Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78333236
153Hyperglycinemia (HP:0002154)1.76867158
154Short thorax (HP:0010306)1.76538225
155Cardiovascular calcification (HP:0011915)1.76269263
156Vitreoretinal degeneration (HP:0000655)1.75987976
157Abnormal rod and cone electroretinograms (HP:0008323)1.75771235
158Lower limb hyperreflexia (HP:0002395)1.75084179
159Vomiting (HP:0002013)1.74039718
160Abnormal urine phosphate concentration (HP:0012599)1.73867225
161Congenital stationary night blindness (HP:0007642)1.73591540
162Metaphyseal dysplasia (HP:0100255)1.73090687
163Severe visual impairment (HP:0001141)1.71417131
164CNS demyelination (HP:0007305)1.71065623
165Abnormality of nucleobase metabolism (HP:0010932)1.70031968
166Hypokinesia (HP:0002375)1.68144147
167Opisthotonus (HP:0002179)1.67480325
168Abnormality of fatty-acid metabolism (HP:0004359)1.67161692
169Wide cranial sutures (HP:0010537)1.66989451
170Short femoral neck (HP:0100864)1.66365215
171Flattened epiphyses (HP:0003071)1.64798029
172Congenital hepatic fibrosis (HP:0002612)1.64072429
173Aplasia/Hypoplasia of the sacrum (HP:0008517)1.64015827
174Abnormality of small intestinal villus morphology (HP:0011472)1.63781966
175Villous atrophy (HP:0011473)1.63781966
176Renal tubular acidosis (HP:0001947)1.61106189
177Facial cleft (HP:0002006)1.60735559
178Ketosis (HP:0001946)1.59312413
179Hyperkalemia (HP:0002153)1.52937522
180Medial flaring of the eyebrow (HP:0010747)1.52175419
181Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.50099803
182Hyperglycinuria (HP:0003108)1.49284900
183Abnormality of calcium-phosphate metabolism (HP:0100530)1.47656336
184Postaxial foot polydactyly (HP:0001830)1.47073571
185Hypophosphatemia (HP:0002148)1.45874322
186Hand muscle atrophy (HP:0009130)1.45670948
187Abnormal tarsal ossification (HP:0008369)1.45363385
188Rickets (HP:0002748)1.45005073
189Glycosuria (HP:0003076)1.42131579
190Abnormality of urine glucose concentration (HP:0011016)1.42131579
191Abnormality of alkaline phosphatase activity (HP:0004379)1.41916118
192Carpal bone hypoplasia (HP:0001498)1.41715803

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.96232666
2PDK46.96232666
3TESK15.70798977
4WNK45.08266582
5PRKD34.82303391
6PDK24.66115273
7WNK33.41617714
8ICK3.34670476
9STK393.09840999
10SCYL23.04993864
11TAOK33.01322464
12OXSR12.58219543
13EIF2AK32.56515846
14ZAK2.54241799
15VRK22.53481819
16NUAK12.46854368
17PTK2B2.06886368
18STK38L2.01540060
19STK381.92164747
20RPS6KB21.89096787
21PBK1.81358720
22NEK21.73978043
23EIF2AK11.67498216
24MAP4K21.56704111
25NME21.52227629
26PHKG21.51880005
27PHKG11.51880005
28DYRK1B1.44602939
29TIE11.42881133
30ADRBK21.42267356
31LIMK11.41025830
32WNK11.36800687
33FER1.35451468
34KDR1.35350103
35GRK11.30356347
36MAP2K71.29968341
37BUB11.23474506
38FGFR21.22968962
39PIM21.16580504
40VRK11.16488089
41KIT1.11579275
42TLK11.11091173
43IRAK11.10280747
44CSNK1G31.10148167
45TRIM281.06833153
46NTRK31.06571731
47EPHA21.04508871
48MAP2K31.02157421
49PNCK1.01549900
50PDK10.99809252
51ABL20.98146222
52PINK10.97278228
53CSNK1G10.94585432
54PLK30.90929692
55MAPK150.89666609
56MAP3K30.89270077
57ADRBK10.87696768
58TNK20.84126129
59PASK0.83656689
60FLT30.82691919
61BCKDK0.82469152
62DAPK20.78012838
63IRAK20.77669338
64PDPK10.76923497
65TXK0.75842319
66DYRK30.72542792
67STK30.72423923
68CSNK1A10.71745346
69TTK0.69531181
70ACVR1B0.68132762
71MAPKAPK30.66895620
72IRAK40.66614440
73CSNK1A1L0.65336836
74TYRO30.64788169
75CSNK1G20.63647337
76JAK30.63264335
77MAP3K120.62630637
78PRKCE0.61642347
79DAPK10.60432381
80CHEK20.59316026
81INSRR0.59066949
82CDK90.58952020
83BRSK20.58916290
84CDK30.56455863
85TBK10.56199496
86DDR20.56058508
87NEK10.53252509
88TRPM70.51108025
89BCR0.49862432
90RPS6KA50.48861045
91CAMK2D0.48734631
92MAPKAPK50.48636528
93RPS6KA40.47309968
94SGK4940.46356455
95SGK2230.46356455
96CCNB10.45527937
97CDC70.45217153
98ILK0.42590323
99HIPK20.42017596
100CHEK10.40976099
101AURKB0.40146451
102NME10.37871367
103TAOK10.37128239
104MAP3K110.36319215
105PRKG20.35304321
106MST40.34331874
107WEE10.33741651
108FES0.32616778
109DYRK20.32030187
110IKBKB0.31902188
111PRKAA10.31682416
112CDK120.30364156
113LMTK20.27885711
114PAK40.27675051
115ATM0.27590560
116BRSK10.27546961
117ATR0.26315031
118PRKCG0.25522607
119RIPK40.24375429
120PLK10.24340062
121MTOR0.23852161
122MAP2K60.21253976
123CAMK1G0.19858245
124SIK20.19741855
125EPHB10.18552116
126GSK3A0.18479189
127PRKCZ0.17985185
128MUSK0.17505357
129NEK60.17425994
130STK240.17292166
131SGK20.17005360
132MARK30.16006615
133PAK10.15093588
134SGK30.14825356
135FRK0.13420538
136MST1R0.13391829
137PRKCD0.12036015
138MAPK110.11848833
139PRKACG0.11471214
140MAP3K40.10733503
141CDC42BPA0.08890023
142TESK20.08362707
143PLK40.08281300
144STK160.07934115
145SGK10.06274878
146PIM10.05893586
147MARK20.05250263
148CDK10.04430435
149STK100.04318441
150CSNK2A10.04317049
151RPS6KB10.03492390
152PRKCA0.03399555
153AURKA0.02463673
154GSK3B0.02321642
155PRKACA0.01744705
156CDK20.01720627
157PRKCI0.01678233
158STK110.00942176
159MET0.00858673
160IRAK30.00753334
161CSNK2A20.00326785
162RPS6KA1-0.0169337
163PRKG1-0.0163450
164MAPK8-0.0083516
165MAP3K2-0.0024733
166EEF2K-0.0001391

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.67303470
2Propanoate metabolism_Homo sapiens_hsa006403.57816883
3Pyruvate metabolism_Homo sapiens_hsa006203.39248645
4Proteasome_Homo sapiens_hsa030503.20795820
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.19301371
6Selenocompound metabolism_Homo sapiens_hsa004502.73597081
7One carbon pool by folate_Homo sapiens_hsa006702.47654098
8Fatty acid degradation_Homo sapiens_hsa000712.46628561
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26765346
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.24531123
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.18431081
12Cyanoamino acid metabolism_Homo sapiens_hsa004602.18307412
13Fatty acid metabolism_Homo sapiens_hsa012122.15794040
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.09525616
15Fatty acid biosynthesis_Homo sapiens_hsa000612.09393028
16Protein export_Homo sapiens_hsa030602.07384912
17Butanoate metabolism_Homo sapiens_hsa006502.04391414
18Collecting duct acid secretion_Homo sapiens_hsa049662.00659481
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.98293632
20Parkinsons disease_Homo sapiens_hsa050121.97379737
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.94462430
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.90139532
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.87662074
24Carbon metabolism_Homo sapiens_hsa012001.83903723
25Glutathione metabolism_Homo sapiens_hsa004801.79496885
26Glycerolipid metabolism_Homo sapiens_hsa005611.78623585
27Pentose phosphate pathway_Homo sapiens_hsa000301.74867586
28Mineral absorption_Homo sapiens_hsa049781.74780675
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.74521831
30Sulfur metabolism_Homo sapiens_hsa009201.71393282
31Basal transcription factors_Homo sapiens_hsa030221.69950572
32PPAR signaling pathway_Homo sapiens_hsa033201.66230193
33DNA replication_Homo sapiens_hsa030301.62191862
34Protein digestion and absorption_Homo sapiens_hsa049741.61756226
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58561627
36Glucagon signaling pathway_Homo sapiens_hsa049221.53544214
37Ribosome_Homo sapiens_hsa030101.52027479
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.51567364
39Fructose and mannose metabolism_Homo sapiens_hsa000511.49966024
40Vitamin B6 metabolism_Homo sapiens_hsa007501.48965516
41Peroxisome_Homo sapiens_hsa041461.45593752
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42092663
43Linoleic acid metabolism_Homo sapiens_hsa005911.41395885
44Homologous recombination_Homo sapiens_hsa034401.40405372
45Folate biosynthesis_Homo sapiens_hsa007901.35814892
46RNA polymerase_Homo sapiens_hsa030201.35782035
47Caffeine metabolism_Homo sapiens_hsa002321.33651981
48Pyrimidine metabolism_Homo sapiens_hsa002401.32655919
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.31453559
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30358150
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.29059854
52Arginine biosynthesis_Homo sapiens_hsa002201.28517987
53Non-homologous end-joining_Homo sapiens_hsa034501.27600144
54Bile secretion_Homo sapiens_hsa049761.27388516
55RNA degradation_Homo sapiens_hsa030181.24976335
56Regulation of autophagy_Homo sapiens_hsa041401.24410297
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23169905
58Alzheimers disease_Homo sapiens_hsa050101.22847903
59Tryptophan metabolism_Homo sapiens_hsa003801.21683665
60Mismatch repair_Homo sapiens_hsa034301.21369244
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20326021
62Vitamin digestion and absorption_Homo sapiens_hsa049771.19460833
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17755150
64Sulfur relay system_Homo sapiens_hsa041221.15866259
65Maturity onset diabetes of the young_Homo sapiens_hsa049501.15601311
66Base excision repair_Homo sapiens_hsa034101.14602727
67Biosynthesis of amino acids_Homo sapiens_hsa012301.13807427
68Nitrogen metabolism_Homo sapiens_hsa009101.08637131
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.08053973
70Primary bile acid biosynthesis_Homo sapiens_hsa001201.07025049
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05953073
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05006151
73Renin-angiotensin system_Homo sapiens_hsa046141.04837485
74Lysine degradation_Homo sapiens_hsa003101.03318416
75Galactose metabolism_Homo sapiens_hsa000521.02740992
76Steroid biosynthesis_Homo sapiens_hsa001001.02636092
77Type I diabetes mellitus_Homo sapiens_hsa049400.99197547
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97938128
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.93195410
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.92365995
81Tyrosine metabolism_Homo sapiens_hsa003500.89614551
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87786813
83Nucleotide excision repair_Homo sapiens_hsa034200.87581675
84Huntingtons disease_Homo sapiens_hsa050160.87505423
85Chemical carcinogenesis_Homo sapiens_hsa052040.87287804
86beta-Alanine metabolism_Homo sapiens_hsa004100.85839808
87Cardiac muscle contraction_Homo sapiens_hsa042600.82555731
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.82321209
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81044751
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80111830
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79405503
92Thyroid hormone synthesis_Homo sapiens_hsa049180.75973176
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74638226
94Arachidonic acid metabolism_Homo sapiens_hsa005900.71839493
95Fanconi anemia pathway_Homo sapiens_hsa034600.69993607
96Metabolic pathways_Homo sapiens_hsa011000.67213174
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66634439
98Oocyte meiosis_Homo sapiens_hsa041140.66346261
99N-Glycan biosynthesis_Homo sapiens_hsa005100.65819769
100Arginine and proline metabolism_Homo sapiens_hsa003300.65777849
101Other glycan degradation_Homo sapiens_hsa005110.65687619
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65530859
103Starch and sucrose metabolism_Homo sapiens_hsa005000.64546624
104Complement and coagulation cascades_Homo sapiens_hsa046100.64482427
105Phenylalanine metabolism_Homo sapiens_hsa003600.61675816
106Dorso-ventral axis formation_Homo sapiens_hsa043200.60749696
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60432707
108Spliceosome_Homo sapiens_hsa030400.59426244
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58767353
110Fat digestion and absorption_Homo sapiens_hsa049750.58450379
111Insulin secretion_Homo sapiens_hsa049110.58306105
112Asthma_Homo sapiens_hsa053100.57707522
113Purine metabolism_Homo sapiens_hsa002300.54981018
114Histidine metabolism_Homo sapiens_hsa003400.54569613
115mRNA surveillance pathway_Homo sapiens_hsa030150.53686113
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52768334
117Amphetamine addiction_Homo sapiens_hsa050310.52546105
118Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49332529
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.48644111
120Ether lipid metabolism_Homo sapiens_hsa005650.47610248
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45678937
122Olfactory transduction_Homo sapiens_hsa047400.44622285
123Rheumatoid arthritis_Homo sapiens_hsa053230.41805766
124Hedgehog signaling pathway_Homo sapiens_hsa043400.40559397
125RNA transport_Homo sapiens_hsa030130.40334241
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.39274225
127Antigen processing and presentation_Homo sapiens_hsa046120.39048155
128Renin secretion_Homo sapiens_hsa049240.38794695
129Synaptic vesicle cycle_Homo sapiens_hsa047210.37136587
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36522144
131Oxidative phosphorylation_Homo sapiens_hsa001900.36029149
132Vibrio cholerae infection_Homo sapiens_hsa051100.33462954
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29381385
134Inositol phosphate metabolism_Homo sapiens_hsa005620.27764590
135Gastric acid secretion_Homo sapiens_hsa049710.27296472
136Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.26506004
137Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26279777
138ABC transporters_Homo sapiens_hsa020100.25385005
139Fatty acid elongation_Homo sapiens_hsa000620.23226696
140AMPK signaling pathway_Homo sapiens_hsa041520.22877234
141Retinol metabolism_Homo sapiens_hsa008300.17245540

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